PMC:1617083 / 12621-14062
Annnotations
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The curves of blood flow after FeCl3 application indicated a pattern with a gradual decrease before occlusion for the B6 mice (Figure 1B), but for the A/J mice the blood flow decreased abruptly to zero (Figure 1C), demonstrating a marked difference from the B6 strain. The mean occlusion times were significantly different between the two strains (Figure 1A). The size of the carotids in the two strains was noticeably different. The area (mm2) of the lumen (0.066 ± 0.007, n = 6) was significantly less in the A/J mice than for B6 mice (0.128 ± 0.007, n = 6). However, the ratio of the thrombus to lumen was similar for A/J (0.63 ± 0.03) compared to B6 mice (0.67 ± 0.09). Calculated sheer stress rates [25] were 14% less in the A/J mice when compared to B6 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