> top > docs > PMC:1584416 > spans > 5867-7535 > annotations

PMC:1584416 / 5867-7535 JSONTXT

Annnotations TAB JSON ListView MergeView

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1406 0-2 PRP denotes We
T1407 3-12 VBD denotes generated
T1408 13-15 DT denotes an
T1409 29-35 NN denotes allele
T1410 16-19 NN denotes Xpd
T1411 20-25 VB denotes knock
T1412 25-26 HYPH denotes -
T1413 26-28 RP denotes in
T1414 36-40 IN denotes with
T1415 41-42 DT denotes a
T1416 49-57 NN denotes mutation
T1417 43-48 NN denotes point
T1418 58-66 VBG denotes encoding
T1419 67-68 DT denotes a
T1420 87-93 NN denotes change
T1421 69-75 JJ denotes single
T1422 76-81 NN denotes amino
T1423 82-86 NN denotes acid
T1424 94-95 -LRB- denotes (
T1425 95-103 NN denotes XPDG602D
T1426 103-104 -RRB- denotes )
T1427 105-110 VBN denotes found
T1428 111-113 IN denotes in
T1429 114-117 DT denotes the
T1430 123-130 NN denotes patient
T1431 118-122 NN denotes XPCS
T1432 131-136 NN denotes XPCS2
T1433 137-138 -LRB- denotes (
T1434 145-147 NN denotes 1A
T1435 138-144 NN denotes Figure
T1436 147-148 SYM denotes –
T1437 148-150 NN denotes 1C
T1438 150-151 -RRB- denotes )
T1439 151-152 . denotes .
T1440 152-444 sentence denotes mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).
T1441 153-157 NN denotes mRNA
T1442 158-168 NN denotes expression
T1443 203-211 VBN denotes detected
T1444 169-173 IN denotes from
T1445 174-177 DT denotes the
T1446 187-193 NN denotes allele
T1447 178-186 VBN denotes targeted
T1448 194-199 MD denotes could
T1449 200-202 VB denotes be
T1450 212-214 IN denotes in
T1451 215-224 JJ denotes embryonic
T1452 230-235 NNS denotes cells
T1453 225-229 NN denotes stem
T1454 236-238 IN denotes by
T1455 239-241 NN denotes RT
T1456 242-245 NN denotes PCR
T1457 241-242 HYPH denotes -
T1458 246-247 -LRB- denotes (
T1459 254-256 NN denotes 1D
T1460 247-253 NN denotes Figure
T1461 256-257 -RRB- denotes )
T1462 257-259 , denotes ,
T1463 259-267 IN denotes although
T1464 283-290 VBN denotes reduced
T1465 268-278 NN denotes expression
T1466 279-282 VBD denotes was
T1467 291-304 RB denotes approximately
T1468 305-306 CD denotes 5
T1469 306-307 HYPH denotes -
T1470 307-311 RB denotes fold
T1471 312-320 JJ denotes relative
T1472 321-323 IN denotes to
T1473 324-326 NN denotes wt
T1474 343-349 NNS denotes levels
T1475 327-331 NN denotes mRNA
T1476 332-342 NN denotes transcript
T1477 350-352 IN denotes as
T1478 353-363 VBN denotes determined
T1479 364-366 IN denotes by
T1480 367-375 NNP denotes Northern
T1481 376-384 VBG denotes blotting
T1482 385-387 IN denotes of
T1483 388-391 NN denotes RNA
T1484 392-396 IN denotes from
T1485 397-400 DT denotes the
T1486 401-407 NN denotes testis
T1487 408-410 IN denotes of
T1488 411-423 JJ denotes heterozygous
T1489 424-431 NNS denotes animals
T1490 432-433 -LRB- denotes (
T1491 440-442 NN denotes 1E
T1492 433-439 NN denotes Figure
T1493 442-443 -RRB- denotes )
T1494 443-444 . denotes .
T1495 444-628 sentence denotes Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state.
T1496 445-452 IN denotes Because
T1497 467-470 VBD denotes was
T1498 453-460 NN denotes patient
T1499 461-466 NN denotes XPCS2
T1500 582-590 VBN denotes expected
T1501 471-472 DT denotes a
T1502 473-483 NN denotes hemizygote
T1503 484-488 IN denotes with
T1504 489-495 JJ denotes mutant
T1505 500-507 NN denotes protein
T1506 496-499 NN denotes XPD
T1507 508-509 -LRB- denotes (
T1508 509-517 NN denotes XPDG602D
T1509 517-518 -RRB- denotes )
T1510 519-528 VBN denotes expressed
T1511 529-533 IN denotes from
T1512 534-535 DT denotes a
T1513 543-549 NN denotes allele
T1514 536-542 JJ denotes single
T1515 549-551 , denotes ,
T1516 551-554 DT denotes the
T1517 569-577 NN denotes mutation
T1518 555-568 VBG denotes corresponding
T1519 578-581 VBD denotes was
T1520 591-593 TO denotes to
T1521 594-596 VB denotes be
T1522 597-603 JJ denotes viable
T1523 604-606 IN denotes in
T1524 607-610 DT denotes the
T1525 622-627 NN denotes state
T1526 611-621 JJ denotes homozygous
T1527 627-628 . denotes .
T1528 628-765 sentence denotes However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1).
T1529 629-636 RB denotes However
T1530 670-678 VBN denotes observed
T1531 636-638 , denotes ,
T1532 638-648 JJ denotes homozygous
T1533 656-660 NNS denotes mice
T1534 649-655 JJ denotes mutant
T1535 661-665 VBD denotes were
T1536 666-669 RB denotes not
T1537 678-680 , denotes ,
T1538 680-687 CC denotes neither
T1539 688-695 IN denotes amongst
T1540 696-700 JJ denotes live
T1541 701-707 NNS denotes births
T1542 708-711 CC denotes nor
T1543 712-721 JJ denotes embryonic
T1544 722-725 NN denotes day
T1545 747-754 NNS denotes embryos
T1546 726-730 CD denotes 13.5
T1547 731-732 -LRB- denotes (
T1548 732-737 NN denotes E13.5
T1549 737-738 -RRB- denotes )
T1550 739-741 CC denotes or
T1551 742-746 NN denotes E3.5
T1552 755-756 -LRB- denotes (
T1553 756-761 NN denotes Table
T1554 762-763 CD denotes 1
T1555 763-764 -RRB- denotes )
T1556 764-765 . denotes .
T1557 765-860 sentence denotes The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS).
T1558 766-769 DT denotes The
T1559 804-810 NN denotes allele
T1560 770-783 VBG denotes corresponding
T1561 784-795 JJ denotes hypomorphic
T1562 795-797 , denotes ,
T1563 797-803 JJ denotes mutant
T1564 820-830 VBN denotes designated
T1565 811-814 VBD denotes was
T1566 815-819 RB denotes thus
T1567 831-833 IN denotes as
T1568 834-844 JJ denotes homozygous
T1569 845-851 JJ denotes lethal
T1570 852-853 -LRB- denotes (
T1571 853-858 NN denotes †XPCS
T1572 858-859 -RRB- denotes )
T1573 859-860 . denotes .
T1574 860-1050 sentence denotes Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.
T1575 861-871 JJ denotes Homozygous
T1576 872-881 NN denotes lethality
T1577 901-903 VBZ denotes is
T1578 882-884 IN denotes of
T1579 885-888 DT denotes the
T1580 894-900 NN denotes allele
T1581 889-893 NN denotes XPCS
T1582 904-910 RB denotes likely
T1583 911-914 IN denotes due
T1584 915-917 IN denotes to
T1585 918-925 VBN denotes reduced
T1586 926-932 NNS denotes levels
T1587 933-935 IN denotes of
T1588 936-946 NN denotes expression
T1589 947-949 IN denotes of
T1590 950-954 DT denotes this
T1591 965-972 NN denotes protein
T1592 955-964 JJ denotes essential
T1593 973-975 IN denotes as
T1594 976-977 DT denotes a
T1595 978-984 NN denotes result
T1596 985-987 IN denotes of
T1597 988-992 NN denotes gene
T1598 993-1002 NN denotes targeting
T1599 1003-1004 -LRB- denotes (
T1600 1011-1013 NN denotes 1A
T1601 1004-1010 NN denotes Figure
T1602 1013-1014 -RRB- denotes )
T1603 1015-1021 JJ denotes rather
T1604 1022-1026 IN denotes than
T1605 1027-1029 IN denotes to
T1606 1030-1033 DT denotes the
T1607 1034-1042 NN denotes mutation
T1608 1043-1049 PRP denotes itself
T1609 1049-1050 . denotes .
T1610 1050-1162 sentence denotes Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22].
T1611 1051-1054 NN denotes Xpd
T1612 1055-1063 NN denotes ablation
T1613 1077-1079 VBZ denotes is
T1614 1064-1065 -LRB- denotes (
T1615 1072-1074 NN denotes KO
T1616 1065-1070 NN denotes XpdKO
T1617 1071-1072 HYPH denotes /
T1618 1075-1076 -RRB- denotes )
T1619 1080-1089 RB denotes similarly
T1620 1090-1102 JJ denotes incompatible
T1621 1103-1107 IN denotes with
T1622 1108-1112 NN denotes life
T1623 1113-1119 IN denotes beyond
T1624 1120-1123 DT denotes the
T1625 1133-1139 NNS denotes stages
T1626 1124-1132 JJS denotes earliest
T1627 1140-1142 IN denotes of
T1628 1143-1156 NN denotes embryogenesis
T1629 1157-1158 -LRB- denotes [
T1630 1158-1160 CD denotes 22
T1631 1160-1161 -RRB- denotes ]
T1632 1161-1162 . denotes .
T1633 1162-1449 sentence denotes Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data).
T1634 1163-1173 JJ denotes Consistent
T1635 1316-1319 VBD denotes was
T1636 1174-1178 IN denotes with
T1637 1179-1183 DT denotes this
T1638 1184-1198 NN denotes interpretation
T1639 1198-1200 , denotes ,
T1640 1200-1201 DT denotes a
T1641 1225-1233 NN denotes mutation
T1642 1202-1211 JJ denotes different
T1643 1212-1220 VBN denotes targeted
T1644 1221-1224 NN denotes Xpd
T1645 1234-1242 VBG denotes encoding
T1646 1243-1251 NN denotes XPDR683W
T1647 1251-1253 , denotes ,
T1648 1253-1258 WDT denotes which
T1649 1262-1272 VBN denotes associated
T1650 1259-1261 VBZ denotes is
T1651 1273-1277 IN denotes with
T1652 1278-1280 NN denotes XP
T1653 1281-1283 IN denotes in
T1654 1284-1287 DT denotes the
T1655 1299-1304 NN denotes state
T1656 1288-1298 JJ denotes homozygous
T1657 1305-1307 IN denotes in
T1658 1308-1314 NNS denotes humans
T1659 1314-1316 , denotes ,
T1660 1320-1329 RB denotes similarly
T1661 1330-1344 JJ denotes underexpressed
T1662 1345-1348 CC denotes and
T1663 1349-1355 JJ denotes lethal
T1664 1356-1358 IN denotes in
T1665 1359-1362 DT denotes the
T1666 1374-1379 NN denotes state
T1667 1363-1373 JJ denotes homozygous
T1668 1380-1381 -LRB- denotes (
T1669 1381-1391 VBN denotes designated
T1670 1392-1394 IN denotes as
T1671 1395-1398 NN denotes †XP
T1672 1399-1405 NN denotes allele
T1673 1405-1406 -RRB- denotes )
T1674 1407-1408 -LRB- denotes (
T1675 1415-1417 NN denotes 1A
T1676 1408-1414 NN denotes Figure
T1677 1417-1418 SYM denotes –
T1678 1418-1420 NN denotes 1C
T1679 1420-1421 : denotes ;
T1680 1422-1427 NN denotes Table
T1681 1428-1429 CD denotes 1
T1682 1429-1430 : denotes ;
T1683 1431-1442 JJ denotes unpublished
T1684 1443-1447 NNS denotes data
T1685 1447-1448 -RRB- denotes )
T1686 1448-1449 . denotes .
T1687 1449-1668 sentence denotes Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23].
T1688 1450-1454 RB denotes Also
T1689 1554-1562 VBD denotes resulted
T1690 1454-1456 , denotes ,
T1691 1456-1457 DT denotes a
T1692 1478-1486 NN denotes approach
T1693 1458-1467 JJ denotes different
T1694 1468-1477 NN denotes targeting
T1695 1487-1494 VBG denotes leading
T1696 1495-1497 IN denotes to
T1697 1498-1501 DT denotes the
T1698 1502-1505 NN denotes use
T1699 1506-1508 IN denotes of
T1700 1509-1512 DT denotes the
T1701 1522-1525 NN denotes UTR
T1702 1513-1519 JJ denotes native
T1703 1520-1521 CD denotes 3
T1704 1521-1522 SYM denotes ′
T1705 1526-1529 CC denotes and
T1706 1530-1537 NN denotes removal
T1707 1538-1540 IN denotes of
T1708 1541-1544 DT denotes the
T1709 1549-1553 NN denotes gene
T1710 1545-1548 NN denotes neo
T1711 1563-1565 IN denotes in
T1712 1566-1579 NN denotes normalisation
T1713 1580-1582 IN denotes of
T1714 1583-1590 NN denotes XpdXPCS
T1715 1596-1602 NNS denotes levels
T1716 1591-1595 NN denotes mRNA
T1717 1603-1606 CC denotes and
T1718 1607-1613 JJ denotes viable
T1719 1655-1662 NNS denotes animals
T1720 1614-1624 JJ denotes homozygous
T1721 1625-1632 NN denotes XpdXPCS
T1722 1633-1637 NN denotes XPCS
T1723 1632-1633 HYPH denotes /
T1724 1638-1639 -LRB- denotes (
T1725 1648-1653 NN denotes G602D
T1726 1639-1647 NN denotes XPDG602D
T1727 1647-1648 HYPH denotes /
T1728 1653-1654 -RRB- denotes )
T1729 1663-1664 -LRB- denotes [
T1730 1664-1666 CD denotes 23
T1731 1666-1667 -RRB- denotes ]
T1732 1667-1668 . denotes .
R914 T1406 T1407 nsubj We,generated
R915 T1408 T1409 det an,allele
R916 T1409 T1407 dobj allele,generated
R917 T1410 T1409 nmod Xpd,allele
R918 T1411 T1409 amod knock,allele
R919 T1412 T1411 punct -,knock
R920 T1413 T1411 prt in,knock
R921 T1414 T1409 prep with,allele
R922 T1415 T1416 det a,mutation
R924 T1417 T1416 compound point,mutation
R925 T1418 T1416 acl encoding,mutation
R926 T1419 T1420 det a,change
R927 T1420 T1418 dobj change,encoding
R928 T1421 T1420 amod single,change
R929 T1422 T1423 compound amino,acid
R930 T1423 T1420 compound acid,change
R931 T1424 T1425 punct (,XPDG602D
R932 T1425 T1420 parataxis XPDG602D,change
R933 T1426 T1425 punct ),XPDG602D
R934 T1427 T1420 acl found,change
R935 T1428 T1427 prep in,found
R936 T1429 T1430 det the,patient
R938 T1431 T1430 compound XPCS,patient
R939 T1432 T1430 appos XPCS2,patient
R940 T1433 T1434 punct (,1A
R942 T1435 T1434 compound Figure,1A
R943 T1436 T1437 punct –,1C
R944 T1437 T1434 prep 1C,1A
R945 T1438 T1434 punct ),1A
R946 T1439 T1407 punct .,generated
R947 T1441 T1442 compound mRNA,expression
R948 T1442 T1443 nsubjpass expression,detected
R949 T1444 T1442 prep from,expression
R950 T1445 T1446 det the,allele
R952 T1447 T1446 amod targeted,allele
R953 T1448 T1443 aux could,detected
R954 T1449 T1443 auxpass be,detected
R955 T1450 T1443 prep in,detected
R956 T1451 T1452 amod embryonic,cells
R958 T1453 T1452 compound stem,cells
R959 T1454 T1443 prep by,detected
R960 T1455 T1456 compound RT,PCR
R962 T1457 T1456 punct -,PCR
R963 T1458 T1459 punct (,1D
R965 T1460 T1459 compound Figure,1D
R966 T1461 T1459 punct ),1D
R967 T1462 T1443 punct ", ",detected
R968 T1463 T1464 mark although,reduced
R969 T1464 T1443 advcl reduced,detected
R970 T1465 T1464 nsubjpass expression,reduced
R971 T1466 T1464 auxpass was,reduced
R972 T1467 T1468 advmod approximately,5
R973 T1468 T1464 npadvmod 5,reduced
R974 T1469 T1468 punct -,5
R975 T1470 T1468 advmod fold,5
R976 T1471 T1464 advcl relative,reduced
R977 T1472 T1471 prep to,relative
R978 T1473 T1474 compound wt,levels
R979 T1474 T1472 pobj levels,to
R980 T1475 T1474 compound mRNA,levels
R981 T1476 T1474 compound transcript,levels
R982 T1477 T1478 mark as,determined
R983 T1478 T1464 advcl determined,reduced
R984 T1479 T1478 prep by,determined
R985 T1480 T1479 pobj Northern,by
R986 T1481 T1480 amod blotting,Northern
R987 T1482 T1480 prep of,Northern
R988 T1483 T1482 pobj RNA,of
R989 T1484 T1483 prep from,RNA
R990 T1485 T1486 det the,testis
R991 T1486 T1484 pobj testis,from
R992 T1487 T1486 prep of,testis
R993 T1488 T1489 amod heterozygous,animals
R994 T1489 T1487 pobj animals,of
R995 T1490 T1491 punct (,1E
R997 T1492 T1491 compound Figure,1E
R998 T1493 T1491 punct ),1E
R999 T1494 T1443 punct .,detected
R1000 T1496 T1497 mark Because,was
R1001 T1497 T1500 advcl was,expected
R1002 T1498 T1499 compound patient,XPCS2
R1003 T1499 T1497 nsubj XPCS2,was
R1004 T1501 T1502 det a,hemizygote
R1005 T1502 T1497 attr hemizygote,was
R1006 T1503 T1502 prep with,hemizygote
R1007 T1504 T1505 amod mutant,protein
R1009 T1506 T1505 compound XPD,protein
R1010 T1507 T1508 punct (,XPDG602D
R1011 T1508 T1505 parataxis XPDG602D,protein
R1012 T1509 T1508 punct ),XPDG602D
R1013 T1510 T1505 acl expressed,protein
R1014 T1511 T1510 prep from,expressed
R1015 T1512 T1513 det a,allele
R1017 T1514 T1513 amod single,allele
R1018 T1515 T1500 punct ", ",expected
R1019 T1516 T1517 det the,mutation
R1021 T1518 T1517 amod corresponding,mutation
R1022 T1519 T1500 auxpass was,expected
R1023 T1520 T1521 aux to,be
R1024 T1521 T1500 xcomp be,expected
R1025 T1522 T1521 acomp viable,be
R1026 T1523 T1521 prep in,be
R1027 T1524 T1525 det the,state
R1029 T1526 T1525 amod homozygous,state
R1030 T1527 T1500 punct .,expected
R1031 T1529 T1530 advmod However,observed
R1032 T1531 T1530 punct ", ",observed
R1033 T1532 T1533 amod homozygous,mice
R1035 T1534 T1533 amod mutant,mice
R1036 T1535 T1530 auxpass were,observed
R1037 T1536 T1530 neg not,observed
R1038 T1537 T1530 punct ", ",observed
R1039 T1538 T1539 preconj neither,amongst
R1040 T1539 T1530 prep amongst,observed
R1041 T1540 T1541 amod live,births
R1042 T1541 T1539 pobj births,amongst
R1043 T1542 T1541 cc nor,births
R1044 T1543 T1544 amod embryonic,day
R1045 T1544 T1545 nmod day,embryos
R1046 T1545 T1541 conj embryos,births
R1047 T1546 T1544 nummod 13.5,day
R1048 T1547 T1544 punct (,day
R1049 T1548 T1544 appos E13.5,day
R1050 T1549 T1544 punct ),day
R1051 T1550 T1544 cc or,day
R1052 T1551 T1544 conj E3.5,day
R1053 T1552 T1553 punct (,Table
R1054 T1553 T1530 parataxis Table,observed
R1055 T1554 T1553 nummod 1,Table
R1056 T1555 T1553 punct ),Table
R1057 T1556 T1530 punct .,observed
R1058 T1558 T1559 det The,allele
R1059 T1559 T1564 nsubjpass allele,designated
R1060 T1560 T1559 amod corresponding,allele
R1061 T1561 T1559 amod hypomorphic,allele
R1062 T1562 T1559 punct ", ",allele
R1063 T1563 T1559 amod mutant,allele
R1064 T1565 T1564 auxpass was,designated
R1065 T1566 T1564 advmod thus,designated
R1066 T1567 T1564 prep as,designated
R1067 T1568 T1569 amod homozygous,lethal
R1068 T1569 T1567 pobj lethal,as
R1069 T1570 T1571 punct (,†XPCS
R1070 T1571 T1569 parataxis †XPCS,lethal
R1071 T1572 T1571 punct ),†XPCS
R1072 T1573 T1564 punct .,designated
R1073 T1575 T1576 amod Homozygous,lethality
R1074 T1576 T1577 nsubj lethality,is
R1075 T1578 T1576 prep of,lethality
R1076 T1579 T1580 det the,allele
R1078 T1581 T1580 compound XPCS,allele
R1079 T1582 T1583 advmod likely,due
R1080 T1583 T1577 prep due,is
R1081 T1584 T1583 prep to,due
R1082 T1585 T1586 amod reduced,levels
R1083 T1586 T1584 pobj levels,to
R1084 T1587 T1586 prep of,levels
R1085 T1588 T1587 pobj expression,of
R1086 T1589 T1588 prep of,expression
R1087 T1590 T1591 det this,protein
R1089 T1592 T1591 amod essential,protein
R1090 T1593 T1586 prep as,levels
R1091 T1594 T1595 det a,result
R1092 T1595 T1593 pobj result,as
R1093 T1596 T1595 prep of,result
R1094 T1597 T1598 compound gene,targeting
R1095 T1598 T1596 pobj targeting,of
R1096 T1599 T1600 punct (,1A
R1098 T1601 T1600 compound Figure,1A
R1099 T1602 T1600 punct ),1A
R1100 T1603 T1604 amod rather,than
R1101 T1604 T1584 cc than,to
R1102 T1605 T1584 conj to,to
R1103 T1606 T1607 det the,mutation
R1104 T1607 T1605 pobj mutation,to
R1105 T1608 T1607 appos itself,mutation
R1106 T1609 T1577 punct .,is
R1107 T1611 T1612 compound Xpd,ablation
R1108 T1612 T1613 nsubj ablation,is
R1109 T1614 T1615 punct (,KO
R1110 T1615 T1612 parataxis KO,ablation
R1111 T1616 T1615 compound XpdKO,KO
R1112 T1617 T1615 punct /,KO
R1113 T1618 T1615 punct ),KO
R1114 T1619 T1620 advmod similarly,incompatible
R1115 T1620 T1613 acomp incompatible,is
R1116 T1621 T1620 prep with,incompatible
R1117 T1622 T1621 pobj life,with
R1118 T1623 T1622 prep beyond,life
R1119 T1624 T1625 det the,stages
R1121 T1626 T1625 amod earliest,stages
R1122 T1627 T1625 prep of,stages
R1123 T1628 T1627 pobj embryogenesis,of
R1124 T1629 T1630 punct [,22
R1125 T1630 T1613 parataxis 22,is
R1126 T1631 T1630 punct ],22
R1127 T1632 T1613 punct .,is
R1128 T1634 T1635 advcl Consistent,was
R1129 T1636 T1634 prep with,Consistent
R1130 T1637 T1638 det this,interpretation
R1131 T1638 T1636 pobj interpretation,with
R1132 T1639 T1635 punct ", ",was
R1133 T1640 T1641 det a,mutation
R1134 T1641 T1635 nsubj mutation,was
R1135 T1642 T1641 amod different,mutation
R1136 T1643 T1641 amod targeted,mutation
R1137 T1644 T1641 compound Xpd,mutation
R1138 T1645 T1641 acl encoding,mutation
R1139 T1646 T1645 dobj XPDR683W,encoding
R1140 T1647 T1646 punct ", ",XPDR683W
R1141 T1648 T1649 dep which,associated
R1143 T1650 T1649 auxpass is,associated
R1144 T1651 T1649 prep with,associated
R1145 T1652 T1651 pobj XP,with
R1146 T1653 T1649 prep in,associated
R1147 T1654 T1655 det the,state
R1149 T1656 T1655 amod homozygous,state
R1150 T1657 T1649 prep in,associated
R1151 T1658 T1657 pobj humans,in
R1152 T1659 T1635 punct ", ",was
R1153 T1660 T1661 advmod similarly,underexpressed
R1154 T1661 T1635 acomp underexpressed,was
R1155 T1662 T1661 cc and,underexpressed
R1156 T1663 T1661 conj lethal,underexpressed
R1157 T1664 T1635 prep in,was
R1158 T1665 T1666 det the,state
R1160 T1667 T1666 amod homozygous,state
R1161 T1668 T1669 punct (,designated
R1162 T1669 T1635 parataxis designated,was
R1163 T1670 T1669 prep as,designated
R1164 T1671 T1672 compound †XP,allele
R1165 T1672 T1670 pobj allele,as
R1166 T1673 T1669 punct ),designated
R1167 T1674 T1675 punct (,1A
R1169 T1676 T1675 compound Figure,1A
R1170 T1677 T1678 punct –,1C
R1171 T1678 T1675 prep 1C,1A
R1172 T1679 T1675 punct ;,1A
R1173 T1680 T1675 appos Table,1A
R1174 T1681 T1680 nummod 1,Table
R1175 T1682 T1675 punct ;,1A
R1176 T1683 T1684 amod unpublished,data
R1177 T1684 T1675 appos data,1A
R1178 T1685 T1675 punct ),1A
R1179 T1686 T1635 punct .,was
R1180 T1688 T1689 advmod Also,resulted
R1181 T1690 T1689 punct ", ",resulted
R1182 T1691 T1692 det a,approach
R1183 T1692 T1689 nsubj approach,resulted
R1184 T1693 T1692 amod different,approach
R1185 T1694 T1692 compound targeting,approach
R1186 T1695 T1692 acl leading,approach
R1187 T1696 T1695 prep to,leading
R1188 T1697 T1698 det the,use
R1189 T1698 T1696 pobj use,to
R1190 T1699 T1698 prep of,use
R1191 T1700 T1701 det the,UTR
R1192 T1701 T1699 pobj UTR,of
R1193 T1702 T1701 amod native,UTR
R1194 T1703 T1701 nummod 3,UTR
R1195 T1704 T1703 punct ′,3
R1196 T1705 T1698 cc and,use
R1197 T1706 T1698 conj removal,use
R1198 T1707 T1706 prep of,removal
R1199 T1708 T1709 det the,gene
R1201 T1710 T1709 compound neo,gene
R1202 T1711 T1689 prep in,resulted
R1203 T1712 T1711 pobj normalisation,in
R1204 T1713 T1712 prep of,normalisation
R1205 T1714 T1715 compound XpdXPCS,levels
R1207 T1716 T1715 compound mRNA,levels
R1208 T1717 T1712 cc and,normalisation
R1209 T1718 T1719 amod viable,animals
R1210 T1719 T1712 conj animals,normalisation
R1211 T1720 T1719 amod homozygous,animals
R1212 T1721 T1722 nmod XpdXPCS,XPCS
R1213 T1722 T1719 nmod XPCS,animals
R1214 T1723 T1722 punct /,XPCS
R1215 T1724 T1725 punct (,G602D
R1217 T1726 T1725 compound XPDG602D,G602D
R1218 T1727 T1725 punct /,G602D
R1219 T1728 T1725 punct ),G602D
R1220 T1729 T1730 punct [,23
R1221 T1730 T1689 parataxis 23,resulted
R1222 T1731 T1730 punct ],23
R1223 T1732 T1689 punct .,resulted
R923 T1416 T1414 pobj mutation,with
R937 T1430 T1428 pobj patient,in
R941 T1434 T1407 parataxis 1A,generated
R951 T1446 T1444 pobj allele,from
R957 T1452 T1450 pobj cells,in
R961 T1456 T1454 pobj PCR,by
R964 T1459 T1443 parataxis 1D,detected
R996 T1491 T1443 parataxis 1E,detected
R1008 T1505 T1503 pobj protein,with
R1016 T1513 T1511 pobj allele,from
R1020 T1517 T1500 nsubjpass mutation,expected
R1028 T1525 T1523 pobj state,in
R1034 T1533 T1530 nsubjpass mice,observed
R1077 T1580 T1578 pobj allele,of
R1088 T1591 T1589 pobj protein,of
R1097 T1600 T1598 parataxis 1A,targeting
R1120 T1625 T1623 pobj stages,beyond
R1142 T1649 T1646 relcl associated,XPDR683W
R1148 T1655 T1653 pobj state,in
R1159 T1666 T1664 pobj state,in
R1168 T1675 T1635 parataxis 1A,was
R1200 T1709 T1707 pobj gene,of
R1206 T1715 T1713 pobj levels,of
R1216 T1725 T1722 parataxis G602D,XPCS

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1303 16-19 PR:000007164 denotes Xpd
T1304 29-35 SO:0001023 denotes allele
T1305 95-98 PR:000007164 denotes XPD
T1306 158-168 GO:0010467 denotes expression
T1307 187-193 SO:0001023 denotes allele
T1308 215-224 UBERON:0000922 denotes embryonic
T1309 215-235 CL:0002322 denotes embryonic stem cells
T1310 268-278 GO:0010467 denotes expression
T1311 401-407 UBERON:0000473 denotes testis
T1312 424-431 NCBITaxon:33208 denotes animals
T1313 496-499 PR:000007164 denotes XPD
T1314 509-512 PR:000007164 denotes XPD
T1315 519-528 GO:0010467 denotes expressed
T1316 543-549 SO:0001023 denotes allele
T1317 656-660 NCBITaxon:10088 denotes mice
T1318 712-721 UBERON:0000922 denotes embryonic
T1319 747-754 UBERON:0000922 denotes embryos
T1320 804-810 SO:0001023 denotes allele
T1321 894-900 SO:0001023 denotes allele
T1322 936-946 GO:0010467 denotes expression
T1323 988-992 SO:0000704 denotes gene
T1324 1051-1054 PR:000007164 denotes Xpd
T1325 1065-1068 PR:000007164 denotes Xpd
T1326 1108-1112 UBERON:0000104 denotes life
T1327 1143-1156 GO:0009790 denotes embryogenesis
T1328 1221-1224 PR:000007164 denotes Xpd
T1329 1243-1246 PR:000007164 denotes XPD
T1330 1308-1314 NCBITaxon:9606 denotes humans
T1331 1335-1344 GO:0010467 denotes expressed
T1332 1399-1405 SO:0001023 denotes allele
T1333 1520-1525 SO:0000205 denotes 3′UTR
T1334 1549-1553 SO:0000704 denotes gene
T1335 1583-1586 PR:000007164 denotes Xpd
T1336 1625-1628 PR:000007164 denotes Xpd
T1337 1639-1642 PR:000007164 denotes XPD
T1338 1655-1662 NCBITaxon:33208 denotes animals

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1340 16-19 PR_EXT:000007164 denotes Xpd
T1341 29-35 SO_EXT:0001023 denotes allele
T1342 43-57 SO_EXT:point_mutation_entity_or_process denotes point mutation
T1343 58-66 SO_EXT:sequence_coding_function denotes encoding
T1344 76-86 CHEBI_SO_EXT:amino_acid denotes amino acid
T1345 87-93 SO_EXT:sequence_alteration_entity_or_process denotes change
T1346 95-98 PR_EXT:000007164 denotes XPD
T1347 153-157 CHEBI_SO_EXT:mRNA denotes mRNA
T1348 158-168 GO:0010467 denotes expression
T1349 187-193 SO_EXT:0001023 denotes allele
T1350 215-224 UBERON:0000922 denotes embryonic
T1351 215-235 CL:0002322 denotes embryonic stem cells
T1352 230-235 CL_GO_EXT:cell denotes cells
T1353 239-241 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1354 268-278 GO:0010467 denotes expression
T1355 324-326 SO_EXT:wild_type_entity_or_quality denotes wt
T1356 327-331 CHEBI_SO_EXT:mRNA denotes mRNA
T1357 388-391 CHEBI_SO_EXT:RNA denotes RNA
T1358 401-407 UBERON:0000473 denotes testis
T1359 424-431 NCBITaxon:33208 denotes animals
T1360 489-495 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1361 496-499 PR_EXT:000007164 denotes XPD
T1362 500-507 CHEBI_PR_EXT:protein denotes protein
T1363 509-512 PR_EXT:000007164 denotes XPD
T1364 519-528 GO:0010467 denotes expressed
T1365 543-549 SO_EXT:0001023 denotes allele
T1366 569-577 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1367 649-655 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1368 656-660 NCBITaxon:10088 denotes mice
T1369 712-721 UBERON:0000922 denotes embryonic
T1370 747-754 UBERON:0000922 denotes embryos
T1371 797-803 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1372 804-810 SO_EXT:0001023 denotes allele
T1373 845-851 GO_EXT:fatality_or_lethality denotes lethal
T1374 872-881 GO_EXT:fatality_or_lethality denotes lethality
T1375 894-900 SO_EXT:0001023 denotes allele
T1376 936-946 GO:0010467 denotes expression
T1377 965-972 CHEBI_PR_EXT:protein denotes protein
T1378 988-992 SO_EXT:0000704 denotes gene
T1379 1034-1042 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1380 1051-1054 PR_EXT:000007164 denotes Xpd
T1381 1065-1068 PR_EXT:000007164 denotes Xpd
T1382 1108-1112 UBERON:0000104 denotes life
T1383 1143-1156 GO:0009790 denotes embryogenesis
T1384 1221-1224 PR_EXT:000007164 denotes Xpd
T1385 1225-1233 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1386 1234-1242 SO_EXT:sequence_coding_function denotes encoding
T1387 1243-1246 PR_EXT:000007164 denotes XPD
T1388 1308-1314 NCBITaxon:9606 denotes humans
T1389 1335-1344 GO:0010467 denotes expressed
T1390 1349-1355 GO_EXT:fatality_or_lethality denotes lethal
T1391 1399-1405 SO_EXT:0001023 denotes allele
T1392 1520-1525 SO_EXT:0000205 denotes 3′UTR
T1393 1545-1548 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T1394 1549-1553 SO_EXT:0000704 denotes gene
T1395 1583-1586 PR_EXT:000007164 denotes Xpd
T1396 1591-1595 CHEBI_SO_EXT:mRNA denotes mRNA
T1397 1625-1628 PR_EXT:000007164 denotes Xpd
T1398 1639-1642 PR_EXT:000007164 denotes XPD
T1399 1655-1662 NCBITaxon:33208 denotes animals

2_test

Id Subject Object Predicate Lexical cue
17020410-9426063-84795139 1158-1160 9426063 denotes 22
17020410-16904611-84795140 1664-1666 16904611 denotes 23
T67903 1158-1160 9426063 denotes 22
T71501 1664-1666 16904611 denotes 23