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PMC:1584416 / 5826-9843 JSONTXT

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Id Subject Object Predicate Lexical cue
T1400 0-10 NN denotes Generation
T1401 11-13 IN denotes of
T1402 14-17 NN denotes Xpd
T1403 27-40 NNS denotes Heterozygotes
T1404 18-26 NN denotes Compound
T1405 40-193 sentence denotes We generated an Xpd knock-in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A–1C).
T1406 41-43 PRP denotes We
T1407 44-53 VBD denotes generated
T1408 54-56 DT denotes an
T1409 70-76 NN denotes allele
T1410 57-60 NN denotes Xpd
T1411 61-66 VB denotes knock
T1412 66-67 HYPH denotes -
T1413 67-69 RP denotes in
T1414 77-81 IN denotes with
T1415 82-83 DT denotes a
T1416 90-98 NN denotes mutation
T1417 84-89 NN denotes point
T1418 99-107 VBG denotes encoding
T1419 108-109 DT denotes a
T1420 128-134 NN denotes change
T1421 110-116 JJ denotes single
T1422 117-122 NN denotes amino
T1423 123-127 NN denotes acid
T1424 135-136 -LRB- denotes (
T1425 136-144 NN denotes XPDG602D
T1426 144-145 -RRB- denotes )
T1427 146-151 VBN denotes found
T1428 152-154 IN denotes in
T1429 155-158 DT denotes the
T1430 164-171 NN denotes patient
T1431 159-163 NN denotes XPCS
T1432 172-177 NN denotes XPCS2
T1433 178-179 -LRB- denotes (
T1434 186-188 NN denotes 1A
T1435 179-185 NN denotes Figure
T1436 188-189 SYM denotes –
T1437 189-191 NN denotes 1C
T1438 191-192 -RRB- denotes )
T1439 192-193 . denotes .
T1440 193-485 sentence denotes mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).
T1441 194-198 NN denotes mRNA
T1442 199-209 NN denotes expression
T1443 244-252 VBN denotes detected
T1444 210-214 IN denotes from
T1445 215-218 DT denotes the
T1446 228-234 NN denotes allele
T1447 219-227 VBN denotes targeted
T1448 235-240 MD denotes could
T1449 241-243 VB denotes be
T1450 253-255 IN denotes in
T1451 256-265 JJ denotes embryonic
T1452 271-276 NNS denotes cells
T1453 266-270 NN denotes stem
T1454 277-279 IN denotes by
T1455 280-282 NN denotes RT
T1456 283-286 NN denotes PCR
T1457 282-283 HYPH denotes -
T1458 287-288 -LRB- denotes (
T1459 295-297 NN denotes 1D
T1460 288-294 NN denotes Figure
T1461 297-298 -RRB- denotes )
T1462 298-300 , denotes ,
T1463 300-308 IN denotes although
T1464 324-331 VBN denotes reduced
T1465 309-319 NN denotes expression
T1466 320-323 VBD denotes was
T1467 332-345 RB denotes approximately
T1468 346-347 CD denotes 5
T1469 347-348 HYPH denotes -
T1470 348-352 RB denotes fold
T1471 353-361 JJ denotes relative
T1472 362-364 IN denotes to
T1473 365-367 NN denotes wt
T1474 384-390 NNS denotes levels
T1475 368-372 NN denotes mRNA
T1476 373-383 NN denotes transcript
T1477 391-393 IN denotes as
T1478 394-404 VBN denotes determined
T1479 405-407 IN denotes by
T1480 408-416 NNP denotes Northern
T1481 417-425 VBG denotes blotting
T1482 426-428 IN denotes of
T1483 429-432 NN denotes RNA
T1484 433-437 IN denotes from
T1485 438-441 DT denotes the
T1486 442-448 NN denotes testis
T1487 449-451 IN denotes of
T1488 452-464 JJ denotes heterozygous
T1489 465-472 NNS denotes animals
T1490 473-474 -LRB- denotes (
T1491 481-483 NN denotes 1E
T1492 474-480 NN denotes Figure
T1493 483-484 -RRB- denotes )
T1494 484-485 . denotes .
T1495 485-669 sentence denotes Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state.
T1496 486-493 IN denotes Because
T1497 508-511 VBD denotes was
T1498 494-501 NN denotes patient
T1499 502-507 NN denotes XPCS2
T1500 623-631 VBN denotes expected
T1501 512-513 DT denotes a
T1502 514-524 NN denotes hemizygote
T1503 525-529 IN denotes with
T1504 530-536 JJ denotes mutant
T1505 541-548 NN denotes protein
T1506 537-540 NN denotes XPD
T1507 549-550 -LRB- denotes (
T1508 550-558 NN denotes XPDG602D
T1509 558-559 -RRB- denotes )
T1510 560-569 VBN denotes expressed
T1511 570-574 IN denotes from
T1512 575-576 DT denotes a
T1513 584-590 NN denotes allele
T1514 577-583 JJ denotes single
T1515 590-592 , denotes ,
T1516 592-595 DT denotes the
T1517 610-618 NN denotes mutation
T1518 596-609 VBG denotes corresponding
T1519 619-622 VBD denotes was
T1520 632-634 TO denotes to
T1521 635-637 VB denotes be
T1522 638-644 JJ denotes viable
T1523 645-647 IN denotes in
T1524 648-651 DT denotes the
T1525 663-668 NN denotes state
T1526 652-662 JJ denotes homozygous
T1527 668-669 . denotes .
T1528 669-806 sentence denotes However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1).
T1529 670-677 RB denotes However
T1530 711-719 VBN denotes observed
T1531 677-679 , denotes ,
T1532 679-689 JJ denotes homozygous
T1533 697-701 NNS denotes mice
T1534 690-696 JJ denotes mutant
T1535 702-706 VBD denotes were
T1536 707-710 RB denotes not
T1537 719-721 , denotes ,
T1538 721-728 CC denotes neither
T1539 729-736 IN denotes amongst
T1540 737-741 JJ denotes live
T1541 742-748 NNS denotes births
T1542 749-752 CC denotes nor
T1543 753-762 JJ denotes embryonic
T1544 763-766 NN denotes day
T1545 788-795 NNS denotes embryos
T1546 767-771 CD denotes 13.5
T1547 772-773 -LRB- denotes (
T1548 773-778 NN denotes E13.5
T1549 778-779 -RRB- denotes )
T1550 780-782 CC denotes or
T1551 783-787 NN denotes E3.5
T1552 796-797 -LRB- denotes (
T1553 797-802 NN denotes Table
T1554 803-804 CD denotes 1
T1555 804-805 -RRB- denotes )
T1556 805-806 . denotes .
T1557 806-901 sentence denotes The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS).
T1558 807-810 DT denotes The
T1559 845-851 NN denotes allele
T1560 811-824 VBG denotes corresponding
T1561 825-836 JJ denotes hypomorphic
T1562 836-838 , denotes ,
T1563 838-844 JJ denotes mutant
T1564 861-871 VBN denotes designated
T1565 852-855 VBD denotes was
T1566 856-860 RB denotes thus
T1567 872-874 IN denotes as
T1568 875-885 JJ denotes homozygous
T1569 886-892 JJ denotes lethal
T1570 893-894 -LRB- denotes (
T1571 894-899 NN denotes †XPCS
T1572 899-900 -RRB- denotes )
T1573 900-901 . denotes .
T1574 901-1091 sentence denotes Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.
T1575 902-912 JJ denotes Homozygous
T1576 913-922 NN denotes lethality
T1577 942-944 VBZ denotes is
T1578 923-925 IN denotes of
T1579 926-929 DT denotes the
T1580 935-941 NN denotes allele
T1581 930-934 NN denotes XPCS
T1582 945-951 RB denotes likely
T1583 952-955 IN denotes due
T1584 956-958 IN denotes to
T1585 959-966 VBN denotes reduced
T1586 967-973 NNS denotes levels
T1587 974-976 IN denotes of
T1588 977-987 NN denotes expression
T1589 988-990 IN denotes of
T1590 991-995 DT denotes this
T1591 1006-1013 NN denotes protein
T1592 996-1005 JJ denotes essential
T1593 1014-1016 IN denotes as
T1594 1017-1018 DT denotes a
T1595 1019-1025 NN denotes result
T1596 1026-1028 IN denotes of
T1597 1029-1033 NN denotes gene
T1598 1034-1043 NN denotes targeting
T1599 1044-1045 -LRB- denotes (
T1600 1052-1054 NN denotes 1A
T1601 1045-1051 NN denotes Figure
T1602 1054-1055 -RRB- denotes )
T1603 1056-1062 JJ denotes rather
T1604 1063-1067 IN denotes than
T1605 1068-1070 IN denotes to
T1606 1071-1074 DT denotes the
T1607 1075-1083 NN denotes mutation
T1608 1084-1090 PRP denotes itself
T1609 1090-1091 . denotes .
T1610 1091-1203 sentence denotes Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22].
T1611 1092-1095 NN denotes Xpd
T1612 1096-1104 NN denotes ablation
T1613 1118-1120 VBZ denotes is
T1614 1105-1106 -LRB- denotes (
T1615 1113-1115 NN denotes KO
T1616 1106-1111 NN denotes XpdKO
T1617 1112-1113 HYPH denotes /
T1618 1116-1117 -RRB- denotes )
T1619 1121-1130 RB denotes similarly
T1620 1131-1143 JJ denotes incompatible
T1621 1144-1148 IN denotes with
T1622 1149-1153 NN denotes life
T1623 1154-1160 IN denotes beyond
T1624 1161-1164 DT denotes the
T1625 1174-1180 NNS denotes stages
T1626 1165-1173 JJS denotes earliest
T1627 1181-1183 IN denotes of
T1628 1184-1197 NN denotes embryogenesis
T1629 1198-1199 -LRB- denotes [
T1630 1199-1201 CD denotes 22
T1631 1201-1202 -RRB- denotes ]
T1632 1202-1203 . denotes .
T1633 1203-1490 sentence denotes Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data).
T1634 1204-1214 JJ denotes Consistent
T1635 1357-1360 VBD denotes was
T1636 1215-1219 IN denotes with
T1637 1220-1224 DT denotes this
T1638 1225-1239 NN denotes interpretation
T1639 1239-1241 , denotes ,
T1640 1241-1242 DT denotes a
T1641 1266-1274 NN denotes mutation
T1642 1243-1252 JJ denotes different
T1643 1253-1261 VBN denotes targeted
T1644 1262-1265 NN denotes Xpd
T1645 1275-1283 VBG denotes encoding
T1646 1284-1292 NN denotes XPDR683W
T1647 1292-1294 , denotes ,
T1648 1294-1299 WDT denotes which
T1649 1303-1313 VBN denotes associated
T1650 1300-1302 VBZ denotes is
T1651 1314-1318 IN denotes with
T1652 1319-1321 NN denotes XP
T1653 1322-1324 IN denotes in
T1654 1325-1328 DT denotes the
T1655 1340-1345 NN denotes state
T1656 1329-1339 JJ denotes homozygous
T1657 1346-1348 IN denotes in
T1658 1349-1355 NNS denotes humans
T1659 1355-1357 , denotes ,
T1660 1361-1370 RB denotes similarly
T1661 1371-1385 JJ denotes underexpressed
T1662 1386-1389 CC denotes and
T1663 1390-1396 JJ denotes lethal
T1664 1397-1399 IN denotes in
T1665 1400-1403 DT denotes the
T1666 1415-1420 NN denotes state
T1667 1404-1414 JJ denotes homozygous
T1668 1421-1422 -LRB- denotes (
T1669 1422-1432 VBN denotes designated
T1670 1433-1435 IN denotes as
T1671 1436-1439 NN denotes †XP
T1672 1440-1446 NN denotes allele
T1673 1446-1447 -RRB- denotes )
T1674 1448-1449 -LRB- denotes (
T1675 1456-1458 NN denotes 1A
T1676 1449-1455 NN denotes Figure
T1677 1458-1459 SYM denotes –
T1678 1459-1461 NN denotes 1C
T1679 1461-1462 : denotes ;
T1680 1463-1468 NN denotes Table
T1681 1469-1470 CD denotes 1
T1682 1470-1471 : denotes ;
T1683 1472-1483 JJ denotes unpublished
T1684 1484-1488 NNS denotes data
T1685 1488-1489 -RRB- denotes )
T1686 1489-1490 . denotes .
T1687 1490-1709 sentence denotes Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23].
T1688 1491-1495 RB denotes Also
T1689 1595-1603 VBD denotes resulted
T1690 1495-1497 , denotes ,
T1691 1497-1498 DT denotes a
T1692 1519-1527 NN denotes approach
T1693 1499-1508 JJ denotes different
T1694 1509-1518 NN denotes targeting
T1695 1528-1535 VBG denotes leading
T1696 1536-1538 IN denotes to
T1697 1539-1542 DT denotes the
T1698 1543-1546 NN denotes use
T1699 1547-1549 IN denotes of
T1700 1550-1553 DT denotes the
T1701 1563-1566 NN denotes UTR
T1702 1554-1560 JJ denotes native
T1703 1561-1562 CD denotes 3
T1704 1562-1563 SYM denotes ′
T1705 1567-1570 CC denotes and
T1706 1571-1578 NN denotes removal
T1707 1579-1581 IN denotes of
T1708 1582-1585 DT denotes the
T1709 1590-1594 NN denotes gene
T1710 1586-1589 NN denotes neo
T1711 1604-1606 IN denotes in
T1712 1607-1620 NN denotes normalisation
T1713 1621-1623 IN denotes of
T1714 1624-1631 NN denotes XpdXPCS
T1715 1637-1643 NNS denotes levels
T1716 1632-1636 NN denotes mRNA
T1717 1644-1647 CC denotes and
T1718 1648-1654 JJ denotes viable
T1719 1696-1703 NNS denotes animals
T1720 1655-1665 JJ denotes homozygous
T1721 1666-1673 NN denotes XpdXPCS
T1722 1674-1678 NN denotes XPCS
T1723 1673-1674 HYPH denotes /
T1724 1679-1680 -LRB- denotes (
T1725 1689-1694 NN denotes G602D
T1726 1680-1688 NN denotes XPDG602D
T1727 1688-1689 HYPH denotes /
T1728 1694-1695 -RRB- denotes )
T1729 1704-1705 -LRB- denotes [
T1730 1705-1707 CD denotes 23
T1731 1707-1708 -RRB- denotes ]
T1732 1708-1709 . denotes .
T7095 1720-1729 NN denotes Targeting
T7096 1730-1732 IN denotes of
T7097 1733-1736 DT denotes the
T7098 1747-1751 NN denotes Gene
T7099 1737-1742 NN denotes Mouse
T7100 1743-1746 NN denotes Xpd
T7101 1751-1872 sentence denotes (A) Schematic representation of the genomic structure and partial restriction map of the wt and targeted mouse Xpd loci.
T7102 1752-1753 -LRB- denotes (
T7103 1753-1754 LS denotes A
T7104 1766-1780 NN denotes representation
T7105 1754-1755 -RRB- denotes )
T7106 1756-1765 JJ denotes Schematic
T7107 1781-1783 IN denotes of
T7108 1784-1787 DT denotes the
T7109 1796-1805 NN denotes structure
T7110 1788-1795 JJ denotes genomic
T7111 1806-1809 CC denotes and
T7112 1810-1817 JJ denotes partial
T7113 1830-1833 NN denotes map
T7114 1818-1829 NN denotes restriction
T7115 1834-1836 IN denotes of
T7116 1837-1840 DT denotes the
T7117 1867-1871 NNS denotes loci
T7118 1841-1843 NN denotes wt
T7119 1844-1847 CC denotes and
T7120 1848-1856 VBN denotes targeted
T7121 1857-1862 NN denotes mouse
T7122 1863-1866 NN denotes Xpd
T7123 1871-1872 . denotes .
T7124 1872-1997 sentence denotes For the wt Xpd allele, shaded boxes represent coding regions of exons 12 and 19–23; the 3′UTR is represented by an open box.
T7125 1873-1876 IN denotes For
T7126 1970-1981 VBN denotes represented
T7127 1877-1880 DT denotes the
T7128 1888-1894 NN denotes allele
T7129 1881-1883 NN denotes wt
T7130 1884-1887 NN denotes Xpd
T7131 1894-1896 , denotes ,
T7132 1896-1902 JJ denotes shaded
T7133 1903-1908 NNS denotes boxes
T7134 1909-1918 VBP denotes represent
T7135 1919-1925 VBG denotes coding
T7136 1926-1933 NNS denotes regions
T7137 1934-1936 IN denotes of
T7138 1937-1942 NNS denotes exons
T7139 1943-1945 CD denotes 12
T7140 1946-1949 CC denotes and
T7141 1950-1952 CD denotes 19
T7142 1952-1953 SYM denotes –
T7143 1953-1955 CD denotes 23
T7144 1955-1956 : denotes ;
T7145 1957-1960 DT denotes the
T7146 1963-1966 NN denotes UTR
T7147 1961-1962 CD denotes 3
T7148 1962-1963 SYM denotes ′
T7149 1967-1969 VBZ denotes is
T7150 1982-1984 IN denotes by
T7151 1985-1987 DT denotes an
T7152 1993-1996 NN denotes box
T7153 1988-1992 JJ denotes open
T7154 1996-1997 . denotes .
T7155 1997-2085 sentence denotes TGA indicates the translational stop codon; PolyA indicates the polyadenylation signal.
T7156 1998-2001 NN denotes TGA
T7157 2002-2011 VBZ denotes indicates
T7158 2048-2057 VBZ denotes indicates
T7159 2012-2015 DT denotes the
T7160 2035-2040 NN denotes codon
T7161 2016-2029 JJ denotes translational
T7162 2030-2034 NN denotes stop
T7163 2040-2041 : denotes ;
T7164 2042-2047 NN denotes PolyA
T7165 2058-2061 DT denotes the
T7166 2078-2084 NN denotes signal
T7167 2062-2077 NN denotes polyadenylation
T7168 2084-2085 . denotes .
T7169 2085-2277 sentence denotes For the XpdTTD targeted allele, the 194–base pair (bp) human XPD cDNA fragment fused to exon 22 is indicated as a striped box including the TTD (R722W) mutation indicated by a vertical arrow.
T7170 2086-2089 IN denotes For
T7171 2185-2194 VBN denotes indicated
T7172 2090-2093 DT denotes the
T7173 2110-2116 NN denotes allele
T7174 2094-2100 NN denotes XpdTTD
T7175 2101-2109 VBN denotes targeted
T7176 2116-2118 , denotes ,
T7177 2118-2121 DT denotes the
T7178 2156-2164 NN denotes fragment
T7179 2122-2125 CD denotes 194
T7180 2131-2135 NN denotes pair
T7181 2125-2126 HYPH denotes –
T7182 2126-2130 NN denotes base
T7183 2136-2137 -LRB- denotes (
T7184 2137-2139 NN denotes bp
T7185 2139-2140 -RRB- denotes )
T7186 2141-2146 JJ denotes human
T7187 2147-2150 NN denotes XPD
T7188 2151-2155 NN denotes cDNA
T7189 2165-2170 VBN denotes fused
T7190 2171-2173 IN denotes to
T7191 2174-2178 NN denotes exon
T7192 2179-2181 CD denotes 22
T7193 2182-2184 VBZ denotes is
T7194 2195-2197 IN denotes as
T7195 2198-2199 DT denotes a
T7196 2208-2211 NN denotes box
T7197 2200-2207 VBN denotes striped
T7198 2212-2221 VBG denotes including
T7199 2222-2225 DT denotes the
T7200 2238-2246 NN denotes mutation
T7201 2226-2229 NN denotes TTD
T7202 2230-2231 -LRB- denotes (
T7203 2231-2236 NN denotes R722W
T7204 2236-2237 -RRB- denotes )
T7205 2247-2256 VBN denotes indicated
T7206 2257-2259 IN denotes by
T7207 2260-2261 DT denotes a
T7208 2271-2276 NN denotes arrow
T7209 2262-2270 JJ denotes vertical
T7210 2276-2277 . denotes .
T7211 2277-2449 sentence denotes Chicken β-globin exons 2 and 3 including the 3′UTR are indicated as black boxes with corresponding Roman numerals followed by the β-globin polyadenylation signal (PolyA*).
T7212 2278-2285 NN denotes Chicken
T7213 2301-2302 CD denotes 2
T7214 2286-2287 NN denotes β
T7215 2288-2294 NN denotes globin
T7216 2287-2288 HYPH denotes -
T7217 2295-2300 NNS denotes exons
T7218 2333-2342 VBN denotes indicated
T7219 2303-2306 CC denotes and
T7220 2307-2308 CD denotes 3
T7221 2309-2318 VBG denotes including
T7222 2319-2322 DT denotes the
T7223 2325-2328 NN denotes UTR
T7224 2323-2324 CD denotes 3
T7225 2324-2325 HYPH denotes ′
T7226 2329-2332 VBP denotes are
T7227 2343-2345 IN denotes as
T7228 2346-2351 JJ denotes black
T7229 2352-2357 NNS denotes boxes
T7230 2358-2362 IN denotes with
T7231 2363-2376 VBG denotes corresponding
T7232 2383-2391 NNS denotes numerals
T7233 2377-2382 NNP denotes Roman
T7234 2392-2400 VBN denotes followed
T7235 2401-2403 IN denotes by
T7236 2404-2407 DT denotes the
T7237 2433-2439 NN denotes signal
T7238 2408-2409 NN denotes β
T7239 2410-2416 NN denotes globin
T7240 2409-2410 HYPH denotes -
T7241 2417-2432 NN denotes polyadenylation
T7242 2440-2441 -LRB- denotes (
T7243 2441-2447 NN denotes PolyA*
T7244 2447-2448 -RRB- denotes )
T7245 2448-2449 . denotes .
T7246 2449-2610 sentence denotes For the Xpd†XP and Xpd†XPCS targeted alleles, vertical arrows indicate XPCS (G602D-encoding) and XP (R683W-encoding) mutations in exons 19 and 22, respectively.
T7247 2450-2453 IN denotes For
T7248 2512-2520 VBP denotes indicate
T7249 2454-2457 DT denotes the
T7250 2487-2494 NNS denotes alleles
T7251 2458-2464 NN denotes Xpd†XP
T7252 2465-2468 CC denotes and
T7253 2469-2477 NN denotes Xpd†XPCS
T7254 2478-2486 VBN denotes targeted
T7255 2494-2496 , denotes ,
T7256 2496-2504 JJ denotes vertical
T7257 2505-2511 NNS denotes arrows
T7258 2521-2525 NN denotes XPCS
T7259 2567-2576 NNS denotes mutations
T7260 2526-2527 -LRB- denotes (
T7261 2533-2541 VBG denotes encoding
T7262 2527-2532 NN denotes G602D
T7263 2532-2533 HYPH denotes -
T7264 2541-2542 -RRB- denotes )
T7265 2543-2546 CC denotes and
T7266 2547-2549 NN denotes XP
T7267 2550-2551 -LRB- denotes (
T7268 2557-2565 VBG denotes encoding
T7269 2551-2556 NN denotes R683W
T7270 2556-2557 HYPH denotes -
T7271 2565-2566 -RRB- denotes )
T7272 2577-2579 IN denotes in
T7273 2580-2585 NNS denotes exons
T7274 2586-2588 CD denotes 19
T7275 2589-2592 CC denotes and
T7276 2593-2595 CD denotes 22
T7277 2595-2597 , denotes ,
T7278 2597-2609 RB denotes respectively
T7279 2609-2610 . denotes .
T7280 2610-2703 sentence denotes The unique 3′ probe located outside the targeting construct is marked by a thick black line.
T7281 2611-2614 DT denotes The
T7282 2625-2630 NN denotes probe
T7283 2615-2621 JJ denotes unique
T7284 2622-2623 CD denotes 3
T7285 2623-2624 SYM denotes ′
T7286 2674-2680 VBN denotes marked
T7287 2631-2638 VBN denotes located
T7288 2639-2646 IN denotes outside
T7289 2647-2650 DT denotes the
T7290 2661-2670 NN denotes construct
T7291 2651-2660 VBG denotes targeting
T7292 2671-2673 VBZ denotes is
T7293 2681-2683 IN denotes by
T7294 2684-2685 DT denotes a
T7295 2698-2702 NN denotes line
T7296 2686-2691 JJ denotes thick
T7297 2692-2697 JJ denotes black
T7298 2702-2703 . denotes .
T7299 2703-2783 sentence denotes Restriction sites: B, BamHI; C, ClaI; E, EcoRI; H, HindIII; Hp, HpaI; Sf, SfiI.
T7300 2704-2715 NN denotes Restriction
T7301 2716-2721 NNS denotes sites
T7302 2721-2723 : denotes :
T7303 2723-2724 NN denotes B
T7304 2724-2726 , denotes ,
T7305 2726-2731 NN denotes BamHI
T7306 2731-2732 : denotes ;
T7307 2733-2734 NN denotes C
T7308 2734-2736 , denotes ,
T7309 2736-2740 NN denotes ClaI
T7310 2740-2741 : denotes ;
T7311 2742-2743 NN denotes E
T7312 2743-2745 , denotes ,
T7313 2745-2750 NN denotes EcoRI
T7314 2750-2751 : denotes ;
T7315 2752-2753 NN denotes H
T7316 2753-2755 , denotes ,
T7317 2755-2762 NN denotes HindIII
T7318 2762-2763 : denotes ;
T7319 2764-2766 NN denotes Hp
T7320 2766-2768 , denotes ,
T7321 2768-2772 NN denotes HpaI
T7322 2772-2773 : denotes ;
T7323 2774-2776 NN denotes Sf
T7324 2776-2778 , denotes ,
T7325 2778-2782 NN denotes SfiI
T7326 2782-2783 . denotes .
T7327 2783-2961 sentence denotes (B) Southern blot analysis of EcoRI-digested genomic DNA from wt, Xpd†XPCS/wt, and Xpd†XP/wt recombinant embryonic stem cell clones hybridised with the 3′ probe depicted in (A).
T7328 2784-2785 -LRB- denotes (
T7329 2785-2786 LS denotes B
T7330 2802-2810 NN denotes analysis
T7331 2786-2787 -RRB- denotes )
T7332 2788-2796 NNP denotes Southern
T7333 2797-2801 NN denotes blot
T7334 2811-2813 IN denotes of
T7335 2814-2819 NN denotes EcoRI
T7336 2820-2828 VBN denotes digested
T7337 2819-2820 HYPH denotes -
T7338 2837-2840 NN denotes DNA
T7339 2829-2836 JJ denotes genomic
T7340 2841-2845 IN denotes from
T7341 2846-2848 NN denotes wt
T7342 2909-2915 NNS denotes clones
T7343 2848-2850 , denotes ,
T7344 2850-2858 NN denotes Xpd†XPCS
T7345 2859-2861 NN denotes wt
T7346 2858-2859 HYPH denotes /
T7347 2861-2863 , denotes ,
T7348 2863-2866 CC denotes and
T7349 2867-2873 NN denotes Xpd†XP
T7350 2874-2876 NN denotes wt
T7351 2873-2874 HYPH denotes /
T7352 2877-2888 JJ denotes recombinant
T7353 2889-2898 JJ denotes embryonic
T7354 2904-2908 NN denotes cell
T7355 2899-2903 NN denotes stem
T7356 2916-2926 VBN denotes hybridised
T7357 2927-2931 IN denotes with
T7358 2932-2935 DT denotes the
T7359 2939-2944 NN denotes probe
T7360 2936-2937 CD denotes 3
T7361 2937-2938 SYM denotes ′
T7362 2945-2953 VBN denotes depicted
T7363 2954-2956 IN denotes in
T7364 2957-2958 -LRB- denotes (
T7365 2958-2959 NN denotes A
T7366 2959-2960 -RRB- denotes )
T7367 2960-2961 . denotes .
T7368 2961-3087 sentence denotes The wt allele yields a 6.5-kilobase (kb) fragment, whereas both targeted Xpd†XP and Xpd†XPCS alleles yield a 5.1-kb fragment.
T7369 2962-2965 DT denotes The
T7370 2969-2975 NN denotes allele
T7371 2966-2968 NN denotes wt
T7372 2976-2982 VBZ denotes yields
T7373 2983-2984 DT denotes a
T7374 3003-3011 NN denotes fragment
T7375 2985-2988 CD denotes 6.5
T7376 2989-2997 NN denotes kilobase
T7377 2988-2989 HYPH denotes -
T7378 2998-2999 -LRB- denotes (
T7379 2999-3001 NN denotes kb
T7380 3001-3002 -RRB- denotes )
T7381 3011-3013 , denotes ,
T7382 3013-3020 IN denotes whereas
T7383 3063-3068 VBP denotes yield
T7384 3021-3025 CC denotes both
T7385 3055-3062 NNS denotes alleles
T7386 3026-3034 VBN denotes targeted
T7387 3035-3041 NN denotes Xpd†XP
T7388 3042-3045 CC denotes and
T7389 3046-3054 NN denotes Xpd†XPCS
T7390 3069-3070 DT denotes a
T7391 3078-3086 NN denotes fragment
T7392 3071-3074 CD denotes 5.1
T7393 3075-3077 NN denotes kb
T7394 3074-3075 HYPH denotes -
T7395 3086-3087 . denotes .
T7396 3087-3238 sentence denotes (C) Genotyping of wt and targeted alleles by PCR using primers F2, R1, and mR as indicated in (A) yields fragments of 399 bp and 468 bp, respectively.
T7397 3088-3089 -LRB- denotes (
T7398 3089-3090 LS denotes C
T7399 3092-3102 NN denotes Genotyping
T7400 3090-3091 -RRB- denotes )
T7401 3103-3105 IN denotes of
T7402 3106-3108 NN denotes wt
T7403 3122-3129 NNS denotes alleles
T7404 3109-3112 CC denotes and
T7405 3113-3121 VBN denotes targeted
T7406 3130-3132 IN denotes by
T7407 3133-3136 NN denotes PCR
T7408 3137-3142 VBG denotes using
T7409 3143-3150 NNS denotes primers
T7410 3151-3153 NN denotes F2
T7411 3153-3155 , denotes ,
T7412 3155-3157 NN denotes R1
T7413 3157-3159 , denotes ,
T7414 3159-3162 CC denotes and
T7415 3163-3165 NN denotes mR
T7416 3166-3168 IN denotes as
T7417 3169-3178 VBN denotes indicated
T7418 3179-3181 IN denotes in
T7419 3182-3183 -LRB- denotes (
T7420 3183-3184 LS denotes A
T7421 3193-3202 NNS denotes fragments
T7422 3184-3185 -RRB- denotes )
T7423 3186-3192 VBZ denotes yields
T7424 3203-3205 IN denotes of
T7425 3206-3209 CD denotes 399
T7426 3210-3212 NN denotes bp
T7427 3213-3216 CC denotes and
T7428 3217-3220 CD denotes 468
T7429 3221-3223 NN denotes bp
T7430 3223-3225 , denotes ,
T7431 3225-3237 RB denotes respectively
T7432 3237-3238 . denotes .
T7433 3238-3482 sentence denotes (D) RT-PCR detection of mRNA expression originating from the targeted †XP and †XPCS alleles in embryonic stem cell clones using primers F1 (hybridising outside the targeting construct) and mR as indicated in (A) results in a 1,416-bp fragment.
T7434 3239-3240 -LRB- denotes (
T7435 3240-3241 LS denotes D
T7436 3451-3458 VBZ denotes results
T7437 3241-3242 -RRB- denotes )
T7438 3243-3245 NN denotes RT
T7439 3246-3249 NN denotes PCR
T7440 3245-3246 HYPH denotes -
T7441 3250-3259 NN denotes detection
T7442 3260-3262 IN denotes of
T7443 3263-3267 NN denotes mRNA
T7444 3268-3278 NN denotes expression
T7445 3279-3290 VBG denotes originating
T7446 3291-3295 IN denotes from
T7447 3296-3299 DT denotes the
T7448 3323-3330 NNS denotes alleles
T7449 3300-3308 VBN denotes targeted
T7450 3309-3312 NN denotes †XP
T7451 3313-3316 CC denotes and
T7452 3317-3322 NN denotes †XPCS
T7453 3331-3333 IN denotes in
T7454 3334-3343 JJ denotes embryonic
T7455 3349-3353 NN denotes cell
T7456 3344-3348 NN denotes stem
T7457 3354-3360 NNS denotes clones
T7458 3361-3366 VBG denotes using
T7459 3367-3374 NNS denotes primers
T7460 3375-3377 NN denotes F1
T7461 3378-3379 -LRB- denotes (
T7462 3379-3390 VBG denotes hybridising
T7463 3391-3398 IN denotes outside
T7464 3399-3402 DT denotes the
T7465 3413-3422 NN denotes construct
T7466 3403-3412 VBG denotes targeting
T7467 3422-3423 -RRB- denotes )
T7468 3424-3427 CC denotes and
T7469 3428-3430 NN denotes mR
T7470 3431-3433 IN denotes as
T7471 3434-3443 VBN denotes indicated
T7472 3444-3446 IN denotes in
T7473 3447-3448 -LRB- denotes (
T7474 3448-3449 NN denotes A
T7475 3449-3450 -RRB- denotes )
T7476 3459-3461 IN denotes in
T7477 3462-3463 DT denotes a
T7478 3473-3481 NN denotes fragment
T7479 3464-3469 CD denotes 1,416
T7480 3470-3472 NN denotes bp
T7481 3469-3470 HYPH denotes -
T7482 3481-3482 . denotes .
T7483 3482-3674 sentence denotes (E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD/TTD, heterozygous Xpd†XPCS/wt and XpdTTD/wt, and compound heterozygous Xpd†XPCS/TTD mice as indicated.
T7484 3483-3484 -LRB- denotes (
T7485 3484-3485 LS denotes E
T7486 3501-3509 NN denotes analysis
T7487 3485-3486 -RRB- denotes )
T7488 3487-3495 NNP denotes Northern
T7489 3496-3500 NN denotes blot
T7490 3510-3512 IN denotes of
T7491 3513-3518 JJ denotes total
T7492 3519-3522 NN denotes RNA
T7493 3523-3531 VBN denotes isolated
T7494 3532-3536 IN denotes from
T7495 3537-3543 NN denotes testis
T7496 3544-3546 IN denotes of
T7497 3547-3557 JJ denotes homozygous
T7498 3558-3560 NN denotes wt
T7499 3656-3660 NNS denotes mice
T7500 3561-3564 CC denotes and
T7501 3565-3571 NN denotes XpdTTD
T7502 3572-3575 NN denotes TTD
T7503 3571-3572 HYPH denotes /
T7504 3575-3577 , denotes ,
T7505 3577-3589 JJ denotes heterozygous
T7506 3599-3601 NN denotes wt
T7507 3590-3598 NN denotes Xpd†XPCS
T7508 3598-3599 HYPH denotes /
T7509 3602-3605 CC denotes and
T7510 3606-3612 NN denotes XpdTTD
T7511 3613-3615 NN denotes wt
T7512 3612-3613 HYPH denotes /
T7513 3615-3617 , denotes ,
T7514 3617-3620 CC denotes and
T7515 3621-3629 JJ denotes compound
T7516 3652-3655 NN denotes TTD
T7517 3630-3642 JJ denotes heterozygous
T7518 3643-3651 NN denotes Xpd†XPCS
T7519 3651-3652 HYPH denotes /
T7520 3661-3663 IN denotes as
T7521 3664-3673 VBN denotes indicated
T7522 3673-3674 . denotes .
T7523 3674-3812 sentence denotes Hybridisation with a 1.4-kb mouse Xpd cDNA probe detects mRNAs of 4, 3.3, and 2.7 kb from wt, Xpd†XPCS, and XpdTTD alleles, respectively.
T7524 3675-3688 NN denotes Hybridisation
T7525 3724-3731 VBZ denotes detects
T7526 3689-3693 IN denotes with
T7527 3694-3695 DT denotes a
T7528 3718-3723 NN denotes probe
T7529 3696-3699 CD denotes 1.4
T7530 3700-3702 NN denotes kb
T7531 3699-3700 HYPH denotes -
T7532 3703-3708 NN denotes mouse
T7533 3709-3712 NN denotes Xpd
T7534 3713-3717 NN denotes cDNA
T7535 3732-3737 NNS denotes mRNAs
T7536 3738-3740 IN denotes of
T7537 3741-3742 CD denotes 4
T7538 3757-3759 NN denotes kb
T7539 3742-3744 , denotes ,
T7540 3744-3747 CD denotes 3.3
T7541 3747-3749 , denotes ,
T7542 3749-3752 CC denotes and
T7543 3753-3756 CD denotes 2.7
T7544 3760-3764 IN denotes from
T7545 3765-3767 NN denotes wt
T7546 3790-3797 NNS denotes alleles
T7547 3767-3769 , denotes ,
T7548 3769-3777 NN denotes Xpd†XPCS
T7549 3777-3779 , denotes ,
T7550 3779-3782 CC denotes and
T7551 3783-3789 NN denotes XpdTTD
T7552 3797-3799 , denotes ,
T7553 3799-3811 RB denotes respectively
T7554 3811-3812 . denotes .
T7555 3812-3906 sentence denotes An ethidium bromide (EtBr)–stained gel showing the amount of total RNA loaded is shown below.
T7556 3813-3815 DT denotes An
T7557 3848-3851 NN denotes gel
T7558 3816-3824 NN denotes ethidium
T7559 3825-3832 NN denotes bromide
T7560 3840-3847 VBN denotes stained
T7561 3833-3834 -LRB- denotes (
T7562 3834-3838 NN denotes EtBr
T7563 3838-3839 -RRB- denotes )
T7564 3839-3840 HYPH denotes –
T7565 3894-3899 VBN denotes shown
T7566 3852-3859 VBG denotes showing
T7567 3860-3863 DT denotes the
T7568 3864-3870 NN denotes amount
T7569 3871-3873 IN denotes of
T7570 3874-3879 JJ denotes total
T7571 3880-3883 NN denotes RNA
T7572 3884-3890 VBN denotes loaded
T7573 3891-3893 VBZ denotes is
T7574 3900-3905 RB denotes below
T7575 3905-3906 . denotes .
T9211 3916-3925 NN denotes Frequency
T9212 3926-3928 IN denotes of
T9213 3929-3935 NN denotes Xpd†XP
T9214 3936-3939 NN denotes †XP
T9215 3935-3936 HYPH denotes /
T9216 3939-3941 , denotes ,
T9217 3941-3949 NN denotes Xpd†XPCS
T9218 3950-3955 NN denotes †XPCS
T9219 3949-3950 HYPH denotes /
T9220 3955-3957 , denotes ,
T9221 3957-3960 CC denotes and
T9222 3961-3969 NN denotes Compound
T9223 3990-3995 NN denotes †XPCS
T9224 3970-3982 JJ denotes Heterozygous
T9225 3983-3989 NN denotes Xpd†XP
T9226 3989-3990 HYPH denotes /
T9227 3996-4003 NNS denotes Embryos
T9228 4004-4007 CC denotes and
T9229 4008-4017 NN denotes Offspring
R910 T1401 T1400 prep of,Generation
R911 T1402 T1403 compound Xpd,Heterozygotes
R913 T1404 T1403 compound Compound,Heterozygotes
R914 T1406 T1407 nsubj We,generated
R915 T1408 T1409 det an,allele
R916 T1409 T1407 dobj allele,generated
R917 T1410 T1409 nmod Xpd,allele
R918 T1411 T1409 amod knock,allele
R919 T1412 T1411 punct -,knock
R920 T1413 T1411 prt in,knock
R921 T1414 T1409 prep with,allele
R922 T1415 T1416 det a,mutation
R924 T1417 T1416 compound point,mutation
R925 T1418 T1416 acl encoding,mutation
R926 T1419 T1420 det a,change
R927 T1420 T1418 dobj change,encoding
R928 T1421 T1420 amod single,change
R929 T1422 T1423 compound amino,acid
R930 T1423 T1420 compound acid,change
R931 T1424 T1425 punct (,XPDG602D
R932 T1425 T1420 parataxis XPDG602D,change
R933 T1426 T1425 punct ),XPDG602D
R934 T1427 T1420 acl found,change
R935 T1428 T1427 prep in,found
R936 T1429 T1430 det the,patient
R938 T1431 T1430 compound XPCS,patient
R939 T1432 T1430 appos XPCS2,patient
R940 T1433 T1434 punct (,1A
R942 T1435 T1434 compound Figure,1A
R943 T1436 T1437 punct –,1C
R944 T1437 T1434 prep 1C,1A
R945 T1438 T1434 punct ),1A
R946 T1439 T1407 punct .,generated
R947 T1441 T1442 compound mRNA,expression
R948 T1442 T1443 nsubjpass expression,detected
R949 T1444 T1442 prep from,expression
R950 T1445 T1446 det the,allele
R952 T1447 T1446 amod targeted,allele
R953 T1448 T1443 aux could,detected
R954 T1449 T1443 auxpass be,detected
R955 T1450 T1443 prep in,detected
R956 T1451 T1452 amod embryonic,cells
R958 T1453 T1452 compound stem,cells
R959 T1454 T1443 prep by,detected
R960 T1455 T1456 compound RT,PCR
R962 T1457 T1456 punct -,PCR
R963 T1458 T1459 punct (,1D
R965 T1460 T1459 compound Figure,1D
R966 T1461 T1459 punct ),1D
R967 T1462 T1443 punct ", ",detected
R968 T1463 T1464 mark although,reduced
R969 T1464 T1443 advcl reduced,detected
R970 T1465 T1464 nsubjpass expression,reduced
R971 T1466 T1464 auxpass was,reduced
R972 T1467 T1468 advmod approximately,5
R973 T1468 T1464 npadvmod 5,reduced
R974 T1469 T1468 punct -,5
R975 T1470 T1468 advmod fold,5
R976 T1471 T1464 advcl relative,reduced
R977 T1472 T1471 prep to,relative
R978 T1473 T1474 compound wt,levels
R979 T1474 T1472 pobj levels,to
R980 T1475 T1474 compound mRNA,levels
R981 T1476 T1474 compound transcript,levels
R982 T1477 T1478 mark as,determined
R983 T1478 T1464 advcl determined,reduced
R984 T1479 T1478 prep by,determined
R985 T1480 T1479 pobj Northern,by
R986 T1481 T1480 amod blotting,Northern
R987 T1482 T1480 prep of,Northern
R988 T1483 T1482 pobj RNA,of
R989 T1484 T1483 prep from,RNA
R990 T1485 T1486 det the,testis
R991 T1486 T1484 pobj testis,from
R992 T1487 T1486 prep of,testis
R993 T1488 T1489 amod heterozygous,animals
R994 T1489 T1487 pobj animals,of
R995 T1490 T1491 punct (,1E
R997 T1492 T1491 compound Figure,1E
R998 T1493 T1491 punct ),1E
R999 T1494 T1443 punct .,detected
R1000 T1496 T1497 mark Because,was
R1001 T1497 T1500 advcl was,expected
R1002 T1498 T1499 compound patient,XPCS2
R1003 T1499 T1497 nsubj XPCS2,was
R1004 T1501 T1502 det a,hemizygote
R1005 T1502 T1497 attr hemizygote,was
R1006 T1503 T1502 prep with,hemizygote
R1007 T1504 T1505 amod mutant,protein
R1009 T1506 T1505 compound XPD,protein
R1010 T1507 T1508 punct (,XPDG602D
R1011 T1508 T1505 parataxis XPDG602D,protein
R1012 T1509 T1508 punct ),XPDG602D
R1013 T1510 T1505 acl expressed,protein
R1014 T1511 T1510 prep from,expressed
R1015 T1512 T1513 det a,allele
R1017 T1514 T1513 amod single,allele
R1018 T1515 T1500 punct ", ",expected
R1019 T1516 T1517 det the,mutation
R1021 T1518 T1517 amod corresponding,mutation
R1022 T1519 T1500 auxpass was,expected
R1023 T1520 T1521 aux to,be
R1024 T1521 T1500 xcomp be,expected
R1025 T1522 T1521 acomp viable,be
R1026 T1523 T1521 prep in,be
R1027 T1524 T1525 det the,state
R1029 T1526 T1525 amod homozygous,state
R1030 T1527 T1500 punct .,expected
R1031 T1529 T1530 advmod However,observed
R1032 T1531 T1530 punct ", ",observed
R1033 T1532 T1533 amod homozygous,mice
R1035 T1534 T1533 amod mutant,mice
R1036 T1535 T1530 auxpass were,observed
R1037 T1536 T1530 neg not,observed
R1038 T1537 T1530 punct ", ",observed
R1039 T1538 T1539 preconj neither,amongst
R1040 T1539 T1530 prep amongst,observed
R1041 T1540 T1541 amod live,births
R1042 T1541 T1539 pobj births,amongst
R1043 T1542 T1541 cc nor,births
R1044 T1543 T1544 amod embryonic,day
R1045 T1544 T1545 nmod day,embryos
R1046 T1545 T1541 conj embryos,births
R1047 T1546 T1544 nummod 13.5,day
R1048 T1547 T1544 punct (,day
R1049 T1548 T1544 appos E13.5,day
R1050 T1549 T1544 punct ),day
R1051 T1550 T1544 cc or,day
R1052 T1551 T1544 conj E3.5,day
R1053 T1552 T1553 punct (,Table
R1054 T1553 T1530 parataxis Table,observed
R1055 T1554 T1553 nummod 1,Table
R1056 T1555 T1553 punct ),Table
R1057 T1556 T1530 punct .,observed
R1058 T1558 T1559 det The,allele
R1059 T1559 T1564 nsubjpass allele,designated
R1060 T1560 T1559 amod corresponding,allele
R1061 T1561 T1559 amod hypomorphic,allele
R1062 T1562 T1559 punct ", ",allele
R1063 T1563 T1559 amod mutant,allele
R1064 T1565 T1564 auxpass was,designated
R1065 T1566 T1564 advmod thus,designated
R1066 T1567 T1564 prep as,designated
R1067 T1568 T1569 amod homozygous,lethal
R1068 T1569 T1567 pobj lethal,as
R1069 T1570 T1571 punct (,†XPCS
R1070 T1571 T1569 parataxis †XPCS,lethal
R1071 T1572 T1571 punct ),†XPCS
R1072 T1573 T1564 punct .,designated
R1073 T1575 T1576 amod Homozygous,lethality
R1074 T1576 T1577 nsubj lethality,is
R1075 T1578 T1576 prep of,lethality
R1076 T1579 T1580 det the,allele
R1078 T1581 T1580 compound XPCS,allele
R1079 T1582 T1583 advmod likely,due
R1080 T1583 T1577 prep due,is
R1081 T1584 T1583 prep to,due
R1082 T1585 T1586 amod reduced,levels
R1083 T1586 T1584 pobj levels,to
R1084 T1587 T1586 prep of,levels
R1085 T1588 T1587 pobj expression,of
R1086 T1589 T1588 prep of,expression
R1087 T1590 T1591 det this,protein
R1089 T1592 T1591 amod essential,protein
R1090 T1593 T1586 prep as,levels
R1091 T1594 T1595 det a,result
R1092 T1595 T1593 pobj result,as
R1093 T1596 T1595 prep of,result
R1094 T1597 T1598 compound gene,targeting
R1095 T1598 T1596 pobj targeting,of
R1096 T1599 T1600 punct (,1A
R1098 T1601 T1600 compound Figure,1A
R1099 T1602 T1600 punct ),1A
R1100 T1603 T1604 amod rather,than
R1101 T1604 T1584 cc than,to
R1102 T1605 T1584 conj to,to
R1103 T1606 T1607 det the,mutation
R1104 T1607 T1605 pobj mutation,to
R1105 T1608 T1607 appos itself,mutation
R1106 T1609 T1577 punct .,is
R1107 T1611 T1612 compound Xpd,ablation
R1108 T1612 T1613 nsubj ablation,is
R1109 T1614 T1615 punct (,KO
R1110 T1615 T1612 parataxis KO,ablation
R1111 T1616 T1615 compound XpdKO,KO
R1112 T1617 T1615 punct /,KO
R1113 T1618 T1615 punct ),KO
R1114 T1619 T1620 advmod similarly,incompatible
R1115 T1620 T1613 acomp incompatible,is
R1116 T1621 T1620 prep with,incompatible
R1117 T1622 T1621 pobj life,with
R1118 T1623 T1622 prep beyond,life
R1119 T1624 T1625 det the,stages
R1121 T1626 T1625 amod earliest,stages
R1122 T1627 T1625 prep of,stages
R1123 T1628 T1627 pobj embryogenesis,of
R1124 T1629 T1630 punct [,22
R1125 T1630 T1613 parataxis 22,is
R1126 T1631 T1630 punct ],22
R1127 T1632 T1613 punct .,is
R1128 T1634 T1635 advcl Consistent,was
R1129 T1636 T1634 prep with,Consistent
R1130 T1637 T1638 det this,interpretation
R1131 T1638 T1636 pobj interpretation,with
R1132 T1639 T1635 punct ", ",was
R1133 T1640 T1641 det a,mutation
R1134 T1641 T1635 nsubj mutation,was
R1135 T1642 T1641 amod different,mutation
R1136 T1643 T1641 amod targeted,mutation
R1137 T1644 T1641 compound Xpd,mutation
R1138 T1645 T1641 acl encoding,mutation
R1139 T1646 T1645 dobj XPDR683W,encoding
R1140 T1647 T1646 punct ", ",XPDR683W
R1141 T1648 T1649 dep which,associated
R1143 T1650 T1649 auxpass is,associated
R1144 T1651 T1649 prep with,associated
R1145 T1652 T1651 pobj XP,with
R1146 T1653 T1649 prep in,associated
R1147 T1654 T1655 det the,state
R1149 T1656 T1655 amod homozygous,state
R1150 T1657 T1649 prep in,associated
R1151 T1658 T1657 pobj humans,in
R1152 T1659 T1635 punct ", ",was
R1153 T1660 T1661 advmod similarly,underexpressed
R1154 T1661 T1635 acomp underexpressed,was
R1155 T1662 T1661 cc and,underexpressed
R1156 T1663 T1661 conj lethal,underexpressed
R1157 T1664 T1635 prep in,was
R1158 T1665 T1666 det the,state
R1160 T1667 T1666 amod homozygous,state
R1161 T1668 T1669 punct (,designated
R1162 T1669 T1635 parataxis designated,was
R1163 T1670 T1669 prep as,designated
R1164 T1671 T1672 compound †XP,allele
R1165 T1672 T1670 pobj allele,as
R1166 T1673 T1669 punct ),designated
R1167 T1674 T1675 punct (,1A
R1169 T1676 T1675 compound Figure,1A
R1170 T1677 T1678 punct –,1C
R1171 T1678 T1675 prep 1C,1A
R1172 T1679 T1675 punct ;,1A
R1173 T1680 T1675 appos Table,1A
R1174 T1681 T1680 nummod 1,Table
R1175 T1682 T1675 punct ;,1A
R1176 T1683 T1684 amod unpublished,data
R1177 T1684 T1675 appos data,1A
R1178 T1685 T1675 punct ),1A
R1179 T1686 T1635 punct .,was
R1180 T1688 T1689 advmod Also,resulted
R1181 T1690 T1689 punct ", ",resulted
R1182 T1691 T1692 det a,approach
R1183 T1692 T1689 nsubj approach,resulted
R1184 T1693 T1692 amod different,approach
R1185 T1694 T1692 compound targeting,approach
R1186 T1695 T1692 acl leading,approach
R1187 T1696 T1695 prep to,leading
R1188 T1697 T1698 det the,use
R1189 T1698 T1696 pobj use,to
R1190 T1699 T1698 prep of,use
R1191 T1700 T1701 det the,UTR
R1192 T1701 T1699 pobj UTR,of
R1193 T1702 T1701 amod native,UTR
R1194 T1703 T1701 nummod 3,UTR
R1195 T1704 T1703 punct ′,3
R1196 T1705 T1698 cc and,use
R1197 T1706 T1698 conj removal,use
R1198 T1707 T1706 prep of,removal
R1199 T1708 T1709 det the,gene
R1201 T1710 T1709 compound neo,gene
R1202 T1711 T1689 prep in,resulted
R1203 T1712 T1711 pobj normalisation,in
R1204 T1713 T1712 prep of,normalisation
R1205 T1714 T1715 compound XpdXPCS,levels
R1207 T1716 T1715 compound mRNA,levels
R1208 T1717 T1712 cc and,normalisation
R1209 T1718 T1719 amod viable,animals
R1210 T1719 T1712 conj animals,normalisation
R1211 T1720 T1719 amod homozygous,animals
R1212 T1721 T1722 nmod XpdXPCS,XPCS
R1213 T1722 T1719 nmod XPCS,animals
R1214 T1723 T1722 punct /,XPCS
R1215 T1724 T1725 punct (,G602D
R1217 T1726 T1725 compound XPDG602D,G602D
R1218 T1727 T1725 punct /,G602D
R1219 T1728 T1725 punct ),G602D
R1220 T1729 T1730 punct [,23
R1221 T1730 T1689 parataxis 23,resulted
R1222 T1731 T1730 punct ],23
R1223 T1732 T1689 punct .,resulted
R4726 T7096 T7095 prep of,Targeting
R4727 T7097 T7098 det the,Gene
R4728 T7098 T7096 pobj Gene,of
R4729 T7099 T7098 compound Mouse,Gene
R4730 T7100 T7098 compound Xpd,Gene
R4731 T7102 T7103 punct (,A
R4732 T7103 T7104 meta A,representation
R4733 T7105 T7103 punct ),A
R4734 T7106 T7104 amod Schematic,representation
R4735 T7107 T7104 prep of,representation
R4736 T7108 T7109 det the,structure
R4737 T7109 T7107 pobj structure,of
R4738 T7110 T7109 amod genomic,structure
R4739 T7111 T7104 cc and,representation
R4740 T7112 T7113 amod partial,map
R4741 T7113 T7104 conj map,representation
R4742 T7114 T7113 compound restriction,map
R4743 T7115 T7113 prep of,map
R4744 T7116 T7117 det the,loci
R4745 T7117 T7115 pobj loci,of
R4746 T7118 T7117 nmod wt,loci
R4747 T7119 T7118 cc and,wt
R4748 T7120 T7118 conj targeted,wt
R4749 T7121 T7117 compound mouse,loci
R4750 T7122 T7117 compound Xpd,loci
R4751 T7123 T7113 punct .,map
R4752 T7125 T7126 prep For,represented
R4753 T7127 T7128 det the,allele
R4754 T7128 T7125 pobj allele,For
R4755 T7129 T7128 compound wt,allele
R4756 T7130 T7128 compound Xpd,allele
R4757 T7131 T7126 punct ", ",represented
R4758 T7132 T7133 amod shaded,boxes
R4759 T7133 T7134 nsubj boxes,represent
R4760 T7134 T7126 ccomp represent,represented
R4761 T7135 T7136 amod coding,regions
R4762 T7136 T7134 dobj regions,represent
R4763 T7137 T7136 prep of,regions
R4764 T7138 T7139 nmod exons,12
R4765 T7139 T7137 pobj 12,of
R4766 T7140 T7139 cc and,12
R4767 T7141 T7139 conj 19,12
R4768 T7142 T7143 punct –,23
R4769 T7143 T7141 prep 23,19
R4770 T7144 T7126 punct ;,represented
R4771 T7145 T7146 det the,UTR
R4772 T7146 T7126 nsubjpass UTR,represented
R4773 T7147 T7146 nummod 3,UTR
R4774 T7148 T7147 punct ′,3
R4775 T7149 T7126 auxpass is,represented
R4776 T7150 T7126 agent by,represented
R4777 T7151 T7152 det an,box
R4778 T7152 T7150 pobj box,by
R4779 T7153 T7152 amod open,box
R4780 T7154 T7126 punct .,represented
R4781 T7156 T7157 nsubj TGA,indicates
R4782 T7157 T7158 ccomp indicates,indicates
R4783 T7159 T7160 det the,codon
R4784 T7160 T7157 dobj codon,indicates
R4785 T7161 T7160 amod translational,codon
R4786 T7162 T7160 compound stop,codon
R4787 T7163 T7158 punct ;,indicates
R4788 T7164 T7158 nsubj PolyA,indicates
R4789 T7165 T7166 det the,signal
R4790 T7166 T7158 dobj signal,indicates
R4791 T7167 T7166 compound polyadenylation,signal
R4792 T7168 T7158 punct .,indicates
R4793 T7170 T7171 prep For,indicated
R4794 T7172 T7173 det the,allele
R4795 T7173 T7170 pobj allele,For
R4796 T7174 T7173 nmod XpdTTD,allele
R4797 T7175 T7173 amod targeted,allele
R4798 T7176 T7171 punct ", ",indicated
R4799 T7177 T7178 det the,fragment
R4800 T7178 T7171 nsubjpass fragment,indicated
R4801 T7179 T7180 nummod 194,pair
R4802 T7180 T7178 nmod pair,fragment
R4803 T7181 T7180 punct –,pair
R4804 T7182 T7180 nmod base,pair
R4805 T7183 T7180 punct (,pair
R4806 T7184 T7180 appos bp,pair
R4807 T7185 T7178 punct ),fragment
R4808 T7186 T7178 amod human,fragment
R4809 T7187 T7178 compound XPD,fragment
R4810 T7188 T7178 compound cDNA,fragment
R4811 T7189 T7178 acl fused,fragment
R4812 T7190 T7189 prep to,fused
R4813 T7191 T7190 pobj exon,to
R4814 T7192 T7191 nummod 22,exon
R4815 T7193 T7171 auxpass is,indicated
R4816 T7194 T7171 prep as,indicated
R4817 T7195 T7196 det a,box
R4818 T7196 T7194 pobj box,as
R4819 T7197 T7196 amod striped,box
R4820 T7198 T7171 prep including,indicated
R4821 T7199 T7200 det the,mutation
R4822 T7200 T7198 pobj mutation,including
R4823 T7201 T7200 nmod TTD,mutation
R4824 T7202 T7203 punct (,R722W
R4825 T7203 T7201 parataxis R722W,TTD
R4826 T7204 T7203 punct ),R722W
R4827 T7205 T7200 acl indicated,mutation
R4828 T7206 T7205 agent by,indicated
R4829 T7207 T7208 det a,arrow
R4830 T7208 T7206 pobj arrow,by
R4831 T7209 T7208 amod vertical,arrow
R4832 T7210 T7171 punct .,indicated
R4833 T7212 T7213 nmod Chicken,2
R4834 T7213 T7218 nsubjpass 2,indicated
R4835 T7214 T7215 nmod β,globin
R4836 T7215 T7213 nmod globin,2
R4837 T7216 T7215 punct -,globin
R4838 T7217 T7213 nmod exons,2
R4839 T7219 T7213 cc and,2
R4840 T7220 T7213 conj 3,2
R4841 T7221 T7213 prep including,2
R4842 T7222 T7223 det the,UTR
R4843 T7223 T7221 pobj UTR,including
R4844 T7224 T7223 nummod 3,UTR
R4845 T7225 T7224 punct ′,3
R4846 T7226 T7218 auxpass are,indicated
R4847 T7227 T7218 prep as,indicated
R4848 T7228 T7229 amod black,boxes
R4849 T7229 T7227 pobj boxes,as
R4850 T7230 T7229 prep with,boxes
R4851 T7231 T7232 amod corresponding,numerals
R4852 T7232 T7230 pobj numerals,with
R4853 T7233 T7232 compound Roman,numerals
R4854 T7234 T7232 acl followed,numerals
R4855 T7235 T7234 agent by,followed
R4856 T7236 T7237 det the,signal
R4857 T7237 T7235 pobj signal,by
R4858 T7238 T7239 compound β,globin
R4859 T7239 T7237 compound globin,signal
R4860 T7240 T7239 punct -,globin
R4861 T7241 T7237 compound polyadenylation,signal
R4862 T7242 T7243 punct (,PolyA*
R4863 T7243 T7237 parataxis PolyA*,signal
R4864 T7244 T7243 punct ),PolyA*
R4865 T7245 T7218 punct .,indicated
R4866 T7247 T7248 prep For,indicate
R4867 T7249 T7250 det the,alleles
R4868 T7250 T7247 pobj alleles,For
R4869 T7251 T7250 nmod Xpd†XP,alleles
R4870 T7252 T7251 cc and,Xpd†XP
R4871 T7253 T7251 conj Xpd†XPCS,Xpd†XP
R4872 T7254 T7250 amod targeted,alleles
R4873 T7255 T7248 punct ", ",indicate
R4874 T7256 T7257 amod vertical,arrows
R4875 T7257 T7248 nsubj arrows,indicate
R4876 T7258 T7259 nmod XPCS,mutations
R4877 T7259 T7248 dobj mutations,indicate
R4878 T7260 T7261 punct (,encoding
R4879 T7261 T7258 parataxis encoding,XPCS
R4880 T7262 T7261 npadvmod G602D,encoding
R4881 T7263 T7261 punct -,encoding
R4882 T7264 T7261 punct ),encoding
R4883 T7265 T7258 cc and,XPCS
R4884 T7266 T7258 conj XP,XPCS
R4885 T7267 T7268 punct (,encoding
R4886 T7268 T7266 parataxis encoding,XP
R4887 T7269 T7268 npadvmod R683W,encoding
R4888 T7270 T7268 punct -,encoding
R4889 T7271 T7268 punct ),encoding
R4890 T7272 T7259 prep in,mutations
R4891 T7273 T7274 nmod exons,19
R4892 T7274 T7272 pobj 19,in
R4893 T7275 T7274 cc and,19
R4894 T7276 T7274 conj 22,19
R4895 T7277 T7248 punct ", ",indicate
R4896 T7278 T7248 advmod respectively,indicate
R4897 T7279 T7248 punct .,indicate
R4898 T7281 T7282 det The,probe
R4899 T7282 T7286 nsubjpass probe,marked
R4900 T7283 T7282 amod unique,probe
R4901 T7284 T7282 nummod 3,probe
R4902 T7285 T7284 punct ′,3
R4903 T7287 T7282 acl located,probe
R4904 T7288 T7287 prep outside,located
R4905 T7289 T7290 det the,construct
R4906 T7290 T7288 pobj construct,outside
R4907 T7291 T7290 amod targeting,construct
R4908 T7292 T7286 auxpass is,marked
R4909 T7293 T7286 agent by,marked
R4910 T7294 T7295 det a,line
R4911 T7295 T7293 pobj line,by
R4912 T7296 T7295 amod thick,line
R4913 T7297 T7295 amod black,line
R4914 T7298 T7286 punct .,marked
R4915 T7300 T7301 compound Restriction,sites
R4916 T7302 T7301 punct : ,sites
R4917 T7303 T7301 appos B,sites
R4918 T7304 T7303 punct ", ",B
R4919 T7305 T7303 appos BamHI,B
R4920 T7306 T7303 punct ;,B
R4921 T7307 T7303 appos C,B
R4922 T7308 T7307 punct ", ",C
R4923 T7309 T7307 appos ClaI,C
R4924 T7310 T7303 punct ;,B
R4925 T7311 T7303 appos E,B
R4926 T7312 T7311 punct ", ",E
R4927 T7313 T7311 appos EcoRI,E
R4928 T7314 T7303 punct ;,B
R4929 T7315 T7303 appos H,B
R4930 T7316 T7315 punct ", ",H
R4931 T7317 T7315 appos HindIII,H
R4932 T7318 T7303 punct ;,B
R4933 T7319 T7303 appos Hp,B
R4934 T7320 T7319 punct ", ",Hp
R4935 T7321 T7319 appos HpaI,Hp
R4936 T7322 T7303 punct ;,B
R4937 T7323 T7303 appos Sf,B
R4938 T7324 T7323 punct ", ",Sf
R4939 T7325 T7323 appos SfiI,Sf
R4940 T7326 T7301 punct .,sites
R4941 T7328 T7329 punct (,B
R4942 T7329 T7330 meta B,analysis
R4943 T7331 T7329 punct ),B
R4944 T7332 T7333 compound Southern,blot
R4945 T7333 T7330 compound blot,analysis
R4946 T7334 T7330 prep of,analysis
R4947 T7335 T7336 npadvmod EcoRI,digested
R4948 T7336 T7338 amod digested,DNA
R4949 T7337 T7336 punct -,digested
R4950 T7338 T7334 pobj DNA,of
R4951 T7339 T7338 amod genomic,DNA
R4952 T7340 T7338 prep from,DNA
R4953 T7341 T7342 nmod wt,clones
R4954 T7342 T7340 pobj clones,from
R4955 T7343 T7341 punct ", ",wt
R4956 T7344 T7345 compound Xpd†XPCS,wt
R4957 T7345 T7341 conj wt,wt
R4958 T7346 T7345 punct /,wt
R4959 T7347 T7345 punct ", ",wt
R4960 T7348 T7345 cc and,wt
R4961 T7349 T7350 compound Xpd†XP,wt
R4962 T7350 T7345 conj wt,wt
R4963 T7351 T7350 punct /,wt
R4964 T7352 T7342 amod recombinant,clones
R4965 T7353 T7354 amod embryonic,cell
R4966 T7354 T7342 compound cell,clones
R4967 T7355 T7354 compound stem,cell
R4968 T7356 T7342 acl hybridised,clones
R4969 T7357 T7356 prep with,hybridised
R4970 T7358 T7359 det the,probe
R4971 T7359 T7357 pobj probe,with
R4972 T7360 T7359 nummod 3,probe
R4973 T7361 T7360 punct ′,3
R4974 T7362 T7359 acl depicted,probe
R4975 T7363 T7362 prep in,depicted
R4976 T7364 T7363 punct (,in
R4977 T7365 T7363 pobj A,in
R4978 T7366 T7330 punct ),analysis
R4979 T7367 T7330 punct .,analysis
R4980 T7369 T7370 det The,allele
R4981 T7370 T7372 nsubj allele,yields
R4982 T7371 T7370 compound wt,allele
R4983 T7373 T7374 det a,fragment
R4984 T7374 T7372 dobj fragment,yields
R4985 T7375 T7376 nummod 6.5,kilobase
R4986 T7376 T7374 nmod kilobase,fragment
R4987 T7377 T7376 punct -,kilobase
R4988 T7378 T7376 punct (,kilobase
R4989 T7379 T7376 appos kb,kilobase
R4990 T7380 T7374 punct ),fragment
R4991 T7381 T7372 punct ", ",yields
R4992 T7382 T7383 mark whereas,yield
R4993 T7383 T7372 advcl yield,yields
R4994 T7384 T7385 preconj both,alleles
R4995 T7385 T7383 nsubj alleles,yield
R4996 T7386 T7385 amod targeted,alleles
R4997 T7387 T7385 nmod Xpd†XP,alleles
R4998 T7388 T7387 cc and,Xpd†XP
R4999 T7389 T7387 conj Xpd†XPCS,Xpd†XP
R5000 T7390 T7391 det a,fragment
R5001 T7391 T7383 dobj fragment,yield
R5002 T7392 T7393 nummod 5.1,kb
R5003 T7393 T7391 compound kb,fragment
R5004 T7394 T7393 punct -,kb
R5005 T7395 T7372 punct .,yields
R5006 T7397 T7398 punct (,C
R5007 T7398 T7399 meta C,Genotyping
R5008 T7400 T7398 punct ),C
R5009 T7401 T7399 prep of,Genotyping
R5010 T7402 T7403 nmod wt,alleles
R5011 T7403 T7401 pobj alleles,of
R5012 T7404 T7402 cc and,wt
R5013 T7405 T7402 conj targeted,wt
R5014 T7406 T7399 prep by,Genotyping
R5015 T7407 T7406 pobj PCR,by
R5016 T7408 T7399 acl using,Genotyping
R5017 T7409 T7408 dobj primers,using
R5018 T7410 T7409 appos F2,primers
R5019 T7411 T7410 punct ", ",F2
R5020 T7412 T7410 conj R1,F2
R5021 T7413 T7412 punct ", ",R1
R5022 T7414 T7412 cc and,R1
R5023 T7415 T7412 conj mR,R1
R5024 T7416 T7417 mark as,indicated
R5025 T7417 T7408 advcl indicated,using
R5026 T7418 T7408 prep in,using
R5027 T7419 T7420 punct (,A
R5028 T7420 T7421 meta A,fragments
R5029 T7421 T7418 pobj fragments,in
R5030 T7422 T7420 punct ),A
R5031 T7423 T7421 nmod yields,fragments
R5032 T7424 T7421 prep of,fragments
R5033 T7425 T7426 nummod 399,bp
R5034 T7426 T7424 pobj bp,of
R5035 T7427 T7426 cc and,bp
R5036 T7428 T7429 nummod 468,bp
R5037 T7429 T7426 conj bp,bp
R5038 T7430 T7408 punct ", ",using
R5039 T7431 T7408 advmod respectively,using
R5040 T7432 T7399 punct .,Genotyping
R5041 T7434 T7435 punct (,D
R5042 T7435 T7436 meta D,results
R5043 T7437 T7435 punct ),D
R5044 T7438 T7439 compound RT,PCR
R5045 T7439 T7441 compound PCR,detection
R5046 T7440 T7439 punct -,PCR
R5047 T7441 T7436 nsubj detection,results
R5048 T7442 T7441 prep of,detection
R5049 T7443 T7444 compound mRNA,expression
R5050 T7444 T7442 pobj expression,of
R5051 T7445 T7444 acl originating,expression
R5052 T7446 T7445 prep from,originating
R5053 T7447 T7448 det the,alleles
R5054 T7448 T7446 pobj alleles,from
R5055 T7449 T7448 amod targeted,alleles
R5056 T7450 T7448 nmod †XP,alleles
R5057 T7451 T7450 cc and,†XP
R5058 T7452 T7450 conj †XPCS,†XP
R5059 T7453 T7441 prep in,detection
R5060 T7454 T7455 amod embryonic,cell
R5061 T7455 T7457 compound cell,clones
R5062 T7456 T7455 compound stem,cell
R5063 T7457 T7453 pobj clones,in
R5064 T7458 T7441 acl using,detection
R5065 T7459 T7458 dobj primers,using
R5066 T7460 T7459 appos F1,primers
R5067 T7461 T7462 punct (,hybridising
R5068 T7462 T7460 parataxis hybridising,F1
R5069 T7463 T7462 prep outside,hybridising
R5070 T7464 T7465 det the,construct
R5071 T7465 T7463 pobj construct,outside
R5072 T7466 T7465 amod targeting,construct
R5073 T7467 T7462 punct ),hybridising
R5074 T7468 T7460 cc and,F1
R5075 T7469 T7460 conj mR,F1
R5076 T7470 T7471 mark as,indicated
R5077 T7471 T7458 advcl indicated,using
R5078 T7472 T7471 prep in,indicated
R5079 T7473 T7472 punct (,in
R5080 T7474 T7472 pobj A,in
R5081 T7475 T7436 punct ),results
R5082 T7476 T7436 prep in,results
R5083 T7477 T7478 det a,fragment
R5084 T7478 T7476 pobj fragment,in
R5085 T7479 T7480 nummod "1,416",bp
R5086 T7480 T7478 compound bp,fragment
R5087 T7481 T7480 punct -,bp
R5088 T7482 T7436 punct .,results
R5089 T7484 T7485 punct (,E
R5090 T7485 T7486 meta E,analysis
R5091 T7487 T7485 punct ),E
R5092 T7488 T7489 compound Northern,blot
R5093 T7489 T7486 compound blot,analysis
R5094 T7490 T7486 prep of,analysis
R5095 T7491 T7492 amod total,RNA
R5096 T7492 T7490 pobj RNA,of
R5097 T7493 T7492 acl isolated,RNA
R5098 T7494 T7493 prep from,isolated
R5099 T7495 T7494 pobj testis,from
R5100 T7496 T7495 prep of,testis
R5101 T7497 T7498 amod homozygous,wt
R5102 T7498 T7499 nmod wt,mice
R5103 T7499 T7496 pobj mice,of
R5104 T7500 T7498 cc and,wt
R5105 T7501 T7502 compound XpdTTD,TTD
R5106 T7502 T7498 conj TTD,wt
R5107 T7503 T7502 punct /,TTD
R5108 T7504 T7498 punct ", ",wt
R5109 T7505 T7506 amod heterozygous,wt
R5110 T7506 T7498 conj wt,wt
R5111 T7507 T7506 compound Xpd†XPCS,wt
R5112 T7508 T7506 punct /,wt
R5113 T7509 T7506 cc and,wt
R5114 T7510 T7511 compound XpdTTD,wt
R5115 T7511 T7506 conj wt,wt
R5116 T7512 T7511 punct /,wt
R5117 T7513 T7506 punct ", ",wt
R5118 T7514 T7506 cc and,wt
R5119 T7515 T7516 amod compound,TTD
R5120 T7516 T7506 conj TTD,wt
R5121 T7517 T7516 amod heterozygous,TTD
R5122 T7518 T7516 compound Xpd†XPCS,TTD
R5123 T7519 T7516 punct /,TTD
R5124 T7520 T7521 mark as,indicated
R5125 T7521 T7493 advcl indicated,isolated
R5126 T7522 T7486 punct .,analysis
R5127 T7524 T7525 nsubj Hybridisation,detects
R5128 T7526 T7524 prep with,Hybridisation
R5129 T7527 T7528 det a,probe
R5130 T7528 T7526 pobj probe,with
R5131 T7529 T7530 nummod 1.4,kb
R5132 T7530 T7528 compound kb,probe
R5133 T7531 T7530 punct -,kb
R5134 T7532 T7528 compound mouse,probe
R5135 T7533 T7528 compound Xpd,probe
R5136 T7534 T7528 compound cDNA,probe
R5137 T7535 T7525 dobj mRNAs,detects
R5138 T7536 T7535 prep of,mRNAs
R5139 T7537 T7538 nummod 4,kb
R5140 T7538 T7536 pobj kb,of
R5141 T7539 T7537 punct ", ",4
R5142 T7540 T7537 conj 3.3,4
R5143 T7541 T7540 punct ", ",3.3
R5144 T7542 T7540 cc and,3.3
R5145 T7543 T7540 conj 2.7,3.3
R5146 T7544 T7535 prep from,mRNAs
R5147 T7545 T7546 nmod wt,alleles
R5148 T7546 T7544 pobj alleles,from
R5149 T7547 T7545 punct ", ",wt
R5150 T7548 T7545 conj Xpd†XPCS,wt
R5151 T7549 T7548 punct ", ",Xpd†XPCS
R5152 T7550 T7548 cc and,Xpd†XPCS
R5153 T7551 T7548 conj XpdTTD,Xpd†XPCS
R5154 T7552 T7535 punct ", ",mRNAs
R5155 T7553 T7535 advmod respectively,mRNAs
R5156 T7554 T7525 punct .,detects
R5157 T7556 T7557 det An,gel
R5158 T7557 T7565 nsubjpass gel,shown
R5159 T7558 T7559 compound ethidium,bromide
R5160 T7559 T7560 npadvmod bromide,stained
R5161 T7560 T7557 amod stained,gel
R5162 T7561 T7559 punct (,bromide
R5163 T7562 T7559 appos EtBr,bromide
R5164 T7563 T7560 punct ),stained
R5165 T7564 T7560 punct –,stained
R5166 T7566 T7557 acl showing,gel
R5167 T7567 T7568 det the,amount
R5168 T7568 T7566 dobj amount,showing
R5169 T7569 T7568 prep of,amount
R5170 T7570 T7571 amod total,RNA
R5171 T7571 T7569 pobj RNA,of
R5172 T7572 T7571 acl loaded,RNA
R5173 T7573 T7565 auxpass is,shown
R5174 T7574 T7565 advmod below,shown
R5175 T7575 T7565 punct .,shown
R6304 T9212 T9211 prep of,Frequency
R6305 T9213 T9214 compound Xpd†XP,†XP
R6306 T9214 T9212 pobj †XP,of
R6307 T9215 T9214 punct /,†XP
R6308 T9216 T9214 punct ", ",†XP
R6309 T9217 T9218 compound Xpd†XPCS,†XPCS
R6310 T9218 T9214 conj †XPCS,†XP
R6311 T9219 T9218 punct /,†XPCS
R6312 T9220 T9218 punct ", ",†XPCS
R6313 T9221 T9218 cc and,†XPCS
R6314 T9222 T9223 nmod Compound,†XPCS
R6315 T9223 T9218 conj †XPCS,†XPCS
R6316 T9224 T9223 amod Heterozygous,†XPCS
R6317 T9225 T9223 compound Xpd†XP,†XPCS
R6318 T9226 T9223 punct /,†XPCS
R6319 T9227 T9214 appos Embryos,†XP
R6320 T9228 T9227 cc and,Embryos
R6321 T9229 T9227 conj Offspring,Embryos
R912 T1403 T1401 pobj Heterozygotes,of
R923 T1416 T1414 pobj mutation,with
R937 T1430 T1428 pobj patient,in
R941 T1434 T1407 parataxis 1A,generated
R951 T1446 T1444 pobj allele,from
R957 T1452 T1450 pobj cells,in
R961 T1456 T1454 pobj PCR,by
R964 T1459 T1443 parataxis 1D,detected
R996 T1491 T1443 parataxis 1E,detected
R1008 T1505 T1503 pobj protein,with
R1016 T1513 T1511 pobj allele,from
R1020 T1517 T1500 nsubjpass mutation,expected
R1028 T1525 T1523 pobj state,in
R1034 T1533 T1530 nsubjpass mice,observed
R1077 T1580 T1578 pobj allele,of
R1088 T1591 T1589 pobj protein,of
R1097 T1600 T1598 parataxis 1A,targeting
R1120 T1625 T1623 pobj stages,beyond
R1142 T1649 T1646 relcl associated,XPDR683W
R1148 T1655 T1653 pobj state,in
R1159 T1666 T1664 pobj state,in
R1168 T1675 T1635 parataxis 1A,was
R1200 T1709 T1707 pobj gene,of
R1206 T1715 T1713 pobj levels,of
R1216 T1725 T1722 parataxis G602D,XPCS

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1302 14-17 PR:000007164 denotes Xpd
T1303 57-60 PR:000007164 denotes Xpd
T1304 70-76 SO:0001023 denotes allele
T1305 136-139 PR:000007164 denotes XPD
T1306 199-209 GO:0010467 denotes expression
T1307 228-234 SO:0001023 denotes allele
T1308 256-265 UBERON:0000922 denotes embryonic
T1309 256-276 CL:0002322 denotes embryonic stem cells
T1310 309-319 GO:0010467 denotes expression
T1311 442-448 UBERON:0000473 denotes testis
T1312 465-472 NCBITaxon:33208 denotes animals
T1313 537-540 PR:000007164 denotes XPD
T1314 550-553 PR:000007164 denotes XPD
T1315 560-569 GO:0010467 denotes expressed
T1316 584-590 SO:0001023 denotes allele
T1317 697-701 NCBITaxon:10088 denotes mice
T1318 753-762 UBERON:0000922 denotes embryonic
T1319 788-795 UBERON:0000922 denotes embryos
T1320 845-851 SO:0001023 denotes allele
T1321 935-941 SO:0001023 denotes allele
T1322 977-987 GO:0010467 denotes expression
T1323 1029-1033 SO:0000704 denotes gene
T1324 1092-1095 PR:000007164 denotes Xpd
T1325 1106-1109 PR:000007164 denotes Xpd
T1326 1149-1153 UBERON:0000104 denotes life
T6945 2829-2836 SO:0001026 denotes genomic
T6903 1737-1742 NCBITaxon:10088 denotes Mouse
T6904 1743-1746 PR:000007164 denotes Xpd
T6905 1747-1751 SO:0000704 denotes Gene
T6906 1788-1795 SO:0001026 denotes genomic
T6907 1818-1833 SO:0001250 denotes restriction map
T6908 1857-1862 NCBITaxon:10088 denotes mouse
T6909 1863-1866 PR:000007164 denotes Xpd
T6910 1884-1887 PR:000007164 denotes Xpd
T6911 1888-1894 SO:0001023 denotes allele
T6912 1919-1942 SO:0001215 denotes coding regions of exons
T6913 1961-1966 SO:0000205 denotes 3′UTR
T6914 2016-2034 GO:0006415 denotes translational stop
T6915 2016-2040 SO:0000319 denotes translational stop codon
T6916 2042-2047 SO:0000551 denotes PolyA
T6917 2062-2077 GO:0043631 denotes polyadenylation
T6918 2062-2084 SO:0000551 denotes polyadenylation signal
T6919 2094-2097 PR:000007164 denotes Xpd
T6920 2110-2116 SO:0001023 denotes allele
T6921 2126-2135 SO:0000028 denotes base pair
T6922 2137-2139 SO:0000028 denotes bp
T6923 2141-2146 NCBITaxon:9606 denotes human
T6924 2147-2150 PR:000007164 denotes XPD
T6925 2174-2178 SO:0000147 denotes exon
T6926 2278-2285 NCBITaxon:9031 denotes Chicken
T6927 2286-2294 PR:000008457 denotes β-globin
T6928 2288-2294 CHEBI:5386 denotes globin
T6929 2295-2300 SO:0000147 denotes exons
T6930 2323-2328 SO:0000205 denotes 3′UTR
T6931 2408-2416 PR:000008457 denotes β-globin
T6932 2410-2416 CHEBI:5386 denotes globin
T6933 2417-2432 GO:0043631 denotes polyadenylation
T6934 2417-2439 SO:0000551 denotes polyadenylation signal
T6935 2441-2447 SO:0000551 denotes PolyA*
T6936 2458-2461 PR:000007164 denotes Xpd
T6937 2469-2472 PR:000007164 denotes Xpd
T6938 2487-2494 SO:0001023 denotes alleles
T6939 2580-2585 SO:0000147 denotes exons
T6940 2704-2721 SO:0000061 denotes Restriction sites
T6941 2723-2724 PR:P23940 denotes B
T6942 2726-2731 PR:P23940 denotes BamHI
T6943 2752-2753 PR:P43870 denotes H
T6944 2755-2762 PR:P43870 denotes HindIII
T6946 2850-2853 PR:000007164 denotes Xpd
T6947 2867-2870 PR:000007164 denotes Xpd
T6948 2889-2898 UBERON:0000922 denotes embryonic
T6949 2889-2908 CL:0002322 denotes embryonic stem cell
T6950 2916-2926 GO:0097617 denotes hybridised
T6951 2969-2975 SO:0001023 denotes allele
T6952 3035-3038 PR:000007164 denotes Xpd
T6953 3046-3049 PR:000007164 denotes Xpd
T6954 3055-3062 SO:0001023 denotes alleles
T6955 3122-3129 SO:0001023 denotes alleles
T6956 3143-3150 SO:0000112 denotes primers
T6957 3210-3212 SO:0000028 denotes bp
T6958 3221-3223 SO:0000028 denotes bp
T6959 3268-3278 GO:0010467 denotes expression
T6960 3323-3330 SO:0001023 denotes alleles
T6961 3334-3343 UBERON:0000922 denotes embryonic
T6962 3334-3353 CL:0002322 denotes embryonic stem cell
T6963 3367-3374 SO:0000112 denotes primers
T6964 3379-3390 GO:0097617 denotes hybridising
T6965 3470-3472 SO:0000028 denotes bp
T6966 3537-3543 UBERON:0000473 denotes testis
T6967 3565-3568 PR:000007164 denotes Xpd
T6968 3590-3593 PR:000007164 denotes Xpd
T6969 3643-3646 PR:000007164 denotes Xpd
T6970 3656-3660 NCBITaxon:10088 denotes mice
T6971 3675-3688 GO:0097617 denotes Hybridisation
T6972 3703-3708 NCBITaxon:10088 denotes mouse
T6973 3709-3712 PR:000007164 denotes Xpd
T6974 3769-3772 PR:000007164 denotes Xpd
T6975 3783-3786 PR:000007164 denotes Xpd
T6976 3790-3797 SO:0001023 denotes alleles
T6977 3816-3832 CHEBI:4883 denotes ethidium bromide
T6978 3834-3838 CHEBI:4883 denotes EtBr
T9203 3929-3932 PR:000007164 denotes Xpd
T9204 3941-3944 PR:000007164 denotes Xpd
T9205 3983-3986 PR:000007164 denotes Xpd
T9206 3996-4003 UBERON:0000922 denotes Embryos
T1327 1184-1197 GO:0009790 denotes embryogenesis
T1328 1262-1265 PR:000007164 denotes Xpd
T1329 1284-1287 PR:000007164 denotes XPD
T1330 1349-1355 NCBITaxon:9606 denotes humans
T1331 1376-1385 GO:0010467 denotes expressed
T1332 1440-1446 SO:0001023 denotes allele
T1333 1561-1566 SO:0000205 denotes 3′UTR
T1334 1590-1594 SO:0000704 denotes gene
T1335 1624-1627 PR:000007164 denotes Xpd
T1336 1666-1669 PR:000007164 denotes Xpd
T1337 1680-1683 PR:000007164 denotes XPD
T1338 1696-1703 NCBITaxon:33208 denotes animals

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T1339 14-17 PR_EXT:000007164 denotes Xpd
T1340 57-60 PR_EXT:000007164 denotes Xpd
T1341 70-76 SO_EXT:0001023 denotes allele
T1342 84-98 SO_EXT:point_mutation_entity_or_process denotes point mutation
T1343 99-107 SO_EXT:sequence_coding_function denotes encoding
T1344 117-127 CHEBI_SO_EXT:amino_acid denotes amino acid
T1345 128-134 SO_EXT:sequence_alteration_entity_or_process denotes change
T1346 136-139 PR_EXT:000007164 denotes XPD
T1347 194-198 CHEBI_SO_EXT:mRNA denotes mRNA
T1348 199-209 GO:0010467 denotes expression
T1349 228-234 SO_EXT:0001023 denotes allele
T1350 256-265 UBERON:0000922 denotes embryonic
T1351 256-276 CL:0002322 denotes embryonic stem cells
T1352 271-276 CL_GO_EXT:cell denotes cells
T1353 280-282 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1354 309-319 GO:0010467 denotes expression
T1355 365-367 SO_EXT:wild_type_entity_or_quality denotes wt
T1356 368-372 CHEBI_SO_EXT:mRNA denotes mRNA
T1357 429-432 CHEBI_SO_EXT:RNA denotes RNA
T1358 442-448 UBERON:0000473 denotes testis
T1359 465-472 NCBITaxon:33208 denotes animals
T1360 530-536 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1361 537-540 PR_EXT:000007164 denotes XPD
T1362 541-548 CHEBI_PR_EXT:protein denotes protein
T1363 550-553 PR_EXT:000007164 denotes XPD
T1364 560-569 GO:0010467 denotes expressed
T1365 584-590 SO_EXT:0001023 denotes allele
T1366 610-618 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1367 690-696 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1368 697-701 NCBITaxon:10088 denotes mice
T1369 753-762 UBERON:0000922 denotes embryonic
T1370 788-795 UBERON:0000922 denotes embryos
T1371 838-844 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1372 845-851 SO_EXT:0001023 denotes allele
T1373 886-892 GO_EXT:fatality_or_lethality denotes lethal
T1374 913-922 GO_EXT:fatality_or_lethality denotes lethality
T1375 935-941 SO_EXT:0001023 denotes allele
T1376 977-987 GO:0010467 denotes expression
T1377 1006-1013 CHEBI_PR_EXT:protein denotes protein
T1378 1029-1033 SO_EXT:0000704 denotes gene
T1379 1075-1083 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1380 1092-1095 PR_EXT:000007164 denotes Xpd
T1381 1106-1109 PR_EXT:000007164 denotes Xpd
T1382 1149-1153 UBERON:0000104 denotes life
T1383 1184-1197 GO:0009790 denotes embryogenesis
T1384 1262-1265 PR_EXT:000007164 denotes Xpd
T1385 1266-1274 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1386 1275-1283 SO_EXT:sequence_coding_function denotes encoding
T1387 1284-1287 PR_EXT:000007164 denotes XPD
T1388 1349-1355 NCBITaxon:9606 denotes humans
T1389 1376-1385 GO:0010467 denotes expressed
T1390 1390-1396 GO_EXT:fatality_or_lethality denotes lethal
T1391 1440-1446 SO_EXT:0001023 denotes allele
T1392 1561-1566 SO_EXT:0000205 denotes 3′UTR
T1393 1586-1589 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T1394 1590-1594 SO_EXT:0000704 denotes gene
T1395 1624-1627 PR_EXT:000007164 denotes Xpd
T1396 1632-1636 CHEBI_SO_EXT:mRNA denotes mRNA
T1397 1666-1669 PR_EXT:000007164 denotes Xpd
T1398 1680-1683 PR_EXT:000007164 denotes XPD
T1399 1696-1703 NCBITaxon:33208 denotes animals
T6979 1737-1742 NCBITaxon:10088 denotes Mouse
T6980 1743-1746 PR_EXT:000007164 denotes Xpd
T6981 1747-1751 SO_EXT:0000704 denotes Gene
T6982 1788-1795 SO_EXT:0001026 denotes genomic
T6983 1818-1833 SO_EXT:0001250 denotes restriction map
T6984 1841-1843 SO_EXT:wild_type_entity_or_quality denotes wt
T6985 1857-1862 NCBITaxon:10088 denotes mouse
T6986 1863-1866 PR_EXT:000007164 denotes Xpd
T6987 1881-1883 SO_EXT:wild_type_entity_or_quality denotes wt
T6988 1884-1887 PR_EXT:000007164 denotes Xpd
T6989 1888-1894 SO_EXT:0001023 denotes allele
T6990 1919-1942 SO_EXT:0001215 denotes coding regions of exons
T6991 1961-1966 SO_EXT:0000205 denotes 3′UTR
T6992 2016-2034 GO:0006415 denotes translational stop
T6993 2016-2040 SO_EXT:0000319 denotes translational stop codon
T6994 2042-2047 SO_EXT:0000551 denotes PolyA
T6995 2062-2077 GO:0043631 denotes polyadenylation
T6996 2062-2084 SO_EXT:0000551 denotes polyadenylation signal
T6997 2094-2097 PR_EXT:000007164 denotes Xpd
T6998 2110-2116 SO_EXT:0001023 denotes allele
T6999 2126-2130 CHEBI_SO_EXT:base denotes base
T7000 2126-2135 SO_EXT:0000028 denotes base pair
T7001 2137-2139 SO_EXT:0000028 denotes bp
T7002 2141-2146 NCBITaxon:9606 denotes human
T7003 2147-2150 PR_EXT:000007164 denotes XPD
T7004 2151-2155 SO_EXT:cDNA denotes cDNA
T7005 2165-2170 SO_EXT:sequence_fusion_process denotes fused
T7006 2174-2178 SO_EXT:0000147 denotes exon
T7007 2238-2246 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7008 2278-2285 NCBITaxon:9031 denotes Chicken
T7009 2286-2294 PR_EXT:000008457 denotes β-globin
T7010 2288-2294 CHEBI:5386 denotes globin
T7011 2295-2300 SO_EXT:0000147 denotes exons
T7012 2323-2328 SO_EXT:0000205 denotes 3′UTR
T7013 2408-2416 PR_EXT:000008457 denotes β-globin
T7014 2410-2416 CHEBI:5386 denotes globin
T7015 2417-2432 GO:0043631 denotes polyadenylation
T7016 2417-2439 SO_EXT:0000551 denotes polyadenylation signal
T7017 2441-2447 SO_EXT:0000551 denotes PolyA*
T7018 2458-2461 PR_EXT:000007164 denotes Xpd
T7019 2469-2472 PR_EXT:000007164 denotes Xpd
T7020 2487-2494 SO_EXT:0001023 denotes alleles
T7021 2533-2541 SO_EXT:sequence_coding_function denotes encoding
T7022 2557-2565 SO_EXT:sequence_coding_function denotes encoding
T7023 2567-2576 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7024 2580-2585 SO_EXT:0000147 denotes exons
T7025 2625-2630 CHEBI_SO_EXT:molecular_probe denotes probe
T7026 2661-2670 SO_EXT:engineered_biological_sequence denotes construct
T7027 2704-2721 SO_EXT:0000061 denotes Restriction sites
T7028 2723-2724 PR_EXT:P23940 denotes B
T7029 2726-2731 PR_EXT:P23940 denotes BamHI
T7030 2752-2753 PR_EXT:P43870 denotes H
T7031 2755-2762 PR_EXT:P43870 denotes HindIII
T7032 2829-2840 SO_EXT:genomic_DNA denotes genomic DNA
T7033 2837-2840 CHEBI_SO_EXT:DNA denotes DNA
T7034 2846-2848 SO_EXT:wild_type_entity_or_quality denotes wt
T7035 2850-2853 PR_EXT:000007164 denotes Xpd
T7036 2859-2861 SO_EXT:wild_type_entity_or_quality denotes wt
T7037 2867-2870 PR_EXT:000007164 denotes Xpd
T7038 2874-2876 SO_EXT:wild_type_entity_or_quality denotes wt
T7039 2877-2888 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T7040 2889-2898 UBERON:0000922 denotes embryonic
T7041 2889-2908 CL:0002322 denotes embryonic stem cell
T7042 2904-2908 CL_GO_EXT:cell denotes cell
T7043 2909-2915 SO_EXT:sequence_cloned_entity denotes clones
T7044 2916-2926 GO:0097617 denotes hybridised
T7045 2939-2944 CHEBI_SO_EXT:molecular_probe denotes probe
T7046 2966-2968 SO_EXT:wild_type_entity_or_quality denotes wt
T7047 2969-2975 SO_EXT:0001023 denotes allele
T7048 2993-2997 CHEBI_SO_EXT:base denotes base
T7049 3000-3001 CHEBI_SO_EXT:base denotes b
T7050 3035-3038 PR_EXT:000007164 denotes Xpd
T7051 3046-3049 PR_EXT:000007164 denotes Xpd
T7052 3055-3062 SO_EXT:0001023 denotes alleles
T7053 3076-3077 CHEBI_SO_EXT:base denotes b
T7054 3106-3108 SO_EXT:wild_type_entity_or_quality denotes wt
T7055 3122-3129 SO_EXT:0001023 denotes alleles
T7056 3143-3150 SO_EXT:0000112 denotes primers
T7057 3210-3212 SO_EXT:0000028 denotes bp
T7058 3221-3223 SO_EXT:0000028 denotes bp
T7059 3243-3245 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T7060 3263-3267 CHEBI_SO_EXT:mRNA denotes mRNA
T7061 3268-3278 GO:0010467 denotes expression
T7062 3323-3330 SO_EXT:0001023 denotes alleles
T7063 3334-3343 UBERON:0000922 denotes embryonic
T7064 3334-3353 CL:0002322 denotes embryonic stem cell
T7065 3349-3353 CL_GO_EXT:cell denotes cell
T7066 3354-3360 SO_EXT:sequence_cloned_entity denotes clones
T7067 3367-3374 SO_EXT:0000112 denotes primers
T7068 3379-3390 GO:0097617 denotes hybridising
T7069 3413-3422 SO_EXT:engineered_biological_sequence denotes construct
T7070 3470-3472 SO_EXT:0000028 denotes bp
T7071 3519-3522 CHEBI_SO_EXT:RNA denotes RNA
T7072 3537-3543 UBERON:0000473 denotes testis
T7073 3558-3560 SO_EXT:wild_type_entity_or_quality denotes wt
T7074 3565-3568 PR_EXT:000007164 denotes Xpd
T7075 3590-3593 PR_EXT:000007164 denotes Xpd
T7076 3599-3601 SO_EXT:wild_type_entity_or_quality denotes wt
T7077 3613-3615 SO_EXT:wild_type_entity_or_quality denotes wt
T7078 3643-3646 PR_EXT:000007164 denotes Xpd
T7079 3656-3660 NCBITaxon:10088 denotes mice
T7080 3675-3688 GO:0097617 denotes Hybridisation
T7081 3701-3702 CHEBI_SO_EXT:base denotes b
T7082 3703-3708 NCBITaxon:10088 denotes mouse
T7083 3709-3712 PR_EXT:000007164 denotes Xpd
T7084 3713-3717 SO_EXT:cDNA denotes cDNA
T7085 3718-3723 CHEBI_SO_EXT:molecular_probe denotes probe
T7086 3732-3737 CHEBI_SO_EXT:mRNA denotes mRNAs
T7087 3758-3759 CHEBI_SO_EXT:base denotes b
T7088 3765-3767 SO_EXT:wild_type_entity_or_quality denotes wt
T7089 3769-3772 PR_EXT:000007164 denotes Xpd
T7090 3783-3786 PR_EXT:000007164 denotes Xpd
T7091 3790-3797 SO_EXT:0001023 denotes alleles
T7092 3816-3832 CHEBI:4883 denotes ethidium bromide
T7093 3834-3838 CHEBI:4883 denotes EtBr
T7094 3880-3883 CHEBI_SO_EXT:RNA denotes RNA
T9207 3929-3932 PR_EXT:000007164 denotes Xpd
T9208 3941-3944 PR_EXT:000007164 denotes Xpd
T9209 3983-3986 PR_EXT:000007164 denotes Xpd
T9210 3996-4003 UBERON:0000922 denotes Embryos

2_test

Id Subject Object Predicate Lexical cue
17020410-9426063-84795139 1199-1201 9426063 denotes 22
17020410-16904611-84795140 1705-1707 16904611 denotes 23
T67903 1199-1201 9426063 denotes 22
T71501 1705-1707 16904611 denotes 23