Id |
Subject |
Object |
Predicate |
Lexical cue |
T6053 |
0-2 |
IN |
denotes |
In |
T6054 |
92-99 |
VBZ |
denotes |
remains |
T6055 |
3-9 |
NNS |
denotes |
humans |
T6056 |
9-11 |
, |
denotes |
, |
T6057 |
11-14 |
DT |
denotes |
the |
T6058 |
24-33 |
NN |
denotes |
relevance |
T6059 |
15-23 |
JJ |
denotes |
clinical |
T6060 |
34-36 |
IN |
denotes |
of |
T6061 |
37-46 |
JJ |
denotes |
biallelic |
T6062 |
47-54 |
NNS |
denotes |
effects |
T6063 |
55-59 |
JJ |
denotes |
such |
T6064 |
60-62 |
IN |
denotes |
as |
T6065 |
63-75 |
JJ |
denotes |
interallelic |
T6066 |
76-91 |
NN |
denotes |
complementation |
T6067 |
100-107 |
JJ |
denotes |
unknown |
T6068 |
107-108 |
. |
denotes |
. |
T6069 |
108-352 |
sentence |
denotes |
Although interallelic complementation between two endogenous mutant alleles has been described in cells from a compound heterozygous patient with methylmalonic acidaemia, no observable effects on disease outcome were noted in the patient [28]. |
T6070 |
109-117 |
IN |
denotes |
Although |
T6071 |
194-203 |
VBN |
denotes |
described |
T6072 |
118-130 |
JJ |
denotes |
interallelic |
T6073 |
131-146 |
NN |
denotes |
complementation |
T6074 |
147-154 |
IN |
denotes |
between |
T6075 |
155-158 |
CD |
denotes |
two |
T6076 |
177-184 |
NNS |
denotes |
alleles |
T6077 |
159-169 |
JJ |
denotes |
endogenous |
T6078 |
170-176 |
JJ |
denotes |
mutant |
T6079 |
185-188 |
VBZ |
denotes |
has |
T6080 |
189-193 |
VBN |
denotes |
been |
T6081 |
326-331 |
VBN |
denotes |
noted |
T6082 |
204-206 |
IN |
denotes |
in |
T6083 |
207-212 |
NNS |
denotes |
cells |
T6084 |
213-217 |
IN |
denotes |
from |
T6085 |
218-219 |
DT |
denotes |
a |
T6086 |
242-249 |
NN |
denotes |
patient |
T6087 |
220-228 |
NN |
denotes |
compound |
T6088 |
229-241 |
JJ |
denotes |
heterozygous |
T6089 |
250-254 |
IN |
denotes |
with |
T6090 |
255-268 |
JJ |
denotes |
methylmalonic |
T6091 |
269-278 |
NN |
denotes |
acidaemia |
T6092 |
278-280 |
, |
denotes |
, |
T6093 |
280-282 |
DT |
denotes |
no |
T6094 |
294-301 |
NNS |
denotes |
effects |
T6095 |
283-293 |
JJ |
denotes |
observable |
T6096 |
302-304 |
IN |
denotes |
on |
T6097 |
305-312 |
NN |
denotes |
disease |
T6098 |
313-320 |
NN |
denotes |
outcome |
T6099 |
321-325 |
VBD |
denotes |
were |
T6100 |
332-334 |
IN |
denotes |
in |
T6101 |
335-338 |
DT |
denotes |
the |
T6102 |
339-346 |
NN |
denotes |
patient |
T6103 |
347-348 |
-LRB- |
denotes |
[ |
T6104 |
348-350 |
CD |
denotes |
28 |
T6105 |
350-351 |
-RRB- |
denotes |
] |
T6106 |
351-352 |
. |
denotes |
. |
T6107 |
352-570 |
sentence |
denotes |
Thus, to the best of our knowledge, the amelioration of progeroid features observed here is the first in vivo demonstration in compound heterozygous animals of interallelic complementation relevant to a human disease. |
T6108 |
353-357 |
RB |
denotes |
Thus |
T6109 |
442-444 |
VBZ |
denotes |
is |
T6110 |
357-359 |
, |
denotes |
, |
T6111 |
359-361 |
IN |
denotes |
to |
T6112 |
362-365 |
DT |
denotes |
the |
T6113 |
366-370 |
JJS |
denotes |
best |
T6114 |
371-373 |
IN |
denotes |
of |
T6115 |
374-377 |
PRP$ |
denotes |
our |
T6116 |
378-387 |
NN |
denotes |
knowledge |
T6117 |
387-389 |
, |
denotes |
, |
T6118 |
389-392 |
DT |
denotes |
the |
T6119 |
393-405 |
NN |
denotes |
amelioration |
T6120 |
406-408 |
IN |
denotes |
of |
T6121 |
409-418 |
JJ |
denotes |
progeroid |
T6122 |
419-427 |
NNS |
denotes |
features |
T6123 |
428-436 |
VBN |
denotes |
observed |
T6124 |
437-441 |
RB |
denotes |
here |
T6125 |
445-448 |
DT |
denotes |
the |
T6126 |
463-476 |
NN |
denotes |
demonstration |
T6127 |
449-454 |
JJ |
denotes |
first |
T6128 |
455-457 |
FW |
denotes |
in |
T6129 |
458-462 |
FW |
denotes |
vivo |
T6130 |
477-479 |
IN |
denotes |
in |
T6131 |
480-488 |
NN |
denotes |
compound |
T6132 |
502-509 |
NNS |
denotes |
animals |
T6133 |
489-501 |
JJ |
denotes |
heterozygous |
T6134 |
510-512 |
IN |
denotes |
of |
T6135 |
513-525 |
JJ |
denotes |
interallelic |
T6136 |
526-541 |
NN |
denotes |
complementation |
T6137 |
542-550 |
JJ |
denotes |
relevant |
T6138 |
551-553 |
IN |
denotes |
to |
T6139 |
554-555 |
DT |
denotes |
a |
T6140 |
562-569 |
NN |
denotes |
disease |
T6141 |
556-561 |
JJ |
denotes |
human |
T6142 |
569-570 |
. |
denotes |
. |
T6143 |
570-946 |
sentence |
denotes |
Keeping in mind that the ~1,200 alleles known to exist for the CTRF gene implicated in the common autosomal recessive disorder cystic fibrosis alone [29] can theoretically result in ~700,000 different allelic combinations, the potential number of allelic combinations of different recessive mutations and single nucleotide polymorphisms genome-wide is currently incalculable. |
T6144 |
571-578 |
VBG |
denotes |
Keeping |
T6145 |
920-922 |
VBZ |
denotes |
is |
T6146 |
579-581 |
IN |
denotes |
in |
T6147 |
582-586 |
NN |
denotes |
mind |
T6148 |
587-591 |
IN |
denotes |
that |
T6149 |
743-749 |
VB |
denotes |
result |
T6150 |
592-595 |
DT |
denotes |
the |
T6151 |
603-610 |
NNS |
denotes |
alleles |
T6152 |
596-597 |
SYM |
denotes |
~ |
T6153 |
597-602 |
CD |
denotes |
1,200 |
T6154 |
611-616 |
VBN |
denotes |
known |
T6155 |
617-619 |
TO |
denotes |
to |
T6156 |
620-625 |
VB |
denotes |
exist |
T6157 |
626-629 |
IN |
denotes |
for |
T6158 |
630-633 |
DT |
denotes |
the |
T6159 |
639-643 |
NN |
denotes |
gene |
T6160 |
634-638 |
NN |
denotes |
CTRF |
T6161 |
644-654 |
VBN |
denotes |
implicated |
T6162 |
655-657 |
IN |
denotes |
in |
T6163 |
658-661 |
DT |
denotes |
the |
T6164 |
689-697 |
NN |
denotes |
disorder |
T6165 |
662-668 |
JJ |
denotes |
common |
T6166 |
669-678 |
JJ |
denotes |
autosomal |
T6167 |
679-688 |
JJ |
denotes |
recessive |
T6168 |
698-704 |
JJ |
denotes |
cystic |
T6169 |
705-713 |
NN |
denotes |
fibrosis |
T6170 |
714-719 |
RB |
denotes |
alone |
T6171 |
720-721 |
-LRB- |
denotes |
[ |
T6172 |
721-723 |
CD |
denotes |
29 |
T6173 |
723-724 |
-RRB- |
denotes |
] |
T6174 |
725-728 |
MD |
denotes |
can |
T6175 |
729-742 |
RB |
denotes |
theoretically |
T6176 |
750-752 |
IN |
denotes |
in |
T6177 |
753-754 |
SYM |
denotes |
~ |
T6178 |
754-761 |
CD |
denotes |
700,000 |
T6179 |
780-792 |
NNS |
denotes |
combinations |
T6180 |
762-771 |
JJ |
denotes |
different |
T6181 |
772-779 |
JJ |
denotes |
allelic |
T6182 |
792-794 |
, |
denotes |
, |
T6183 |
794-797 |
DT |
denotes |
the |
T6184 |
808-814 |
NN |
denotes |
number |
T6185 |
798-807 |
JJ |
denotes |
potential |
T6186 |
815-817 |
IN |
denotes |
of |
T6187 |
818-825 |
JJ |
denotes |
allelic |
T6188 |
826-838 |
NNS |
denotes |
combinations |
T6189 |
839-841 |
IN |
denotes |
of |
T6190 |
842-851 |
JJ |
denotes |
different |
T6191 |
862-871 |
NNS |
denotes |
mutations |
T6192 |
852-861 |
JJ |
denotes |
recessive |
T6193 |
872-875 |
CC |
denotes |
and |
T6194 |
876-882 |
JJ |
denotes |
single |
T6195 |
894-907 |
NNS |
denotes |
polymorphisms |
T6196 |
883-893 |
NN |
denotes |
nucleotide |
T6197 |
908-914 |
NN |
denotes |
genome |
T6198 |
915-919 |
JJ |
denotes |
wide |
T6199 |
914-915 |
HYPH |
denotes |
- |
T6200 |
923-932 |
RB |
denotes |
currently |
T6201 |
933-945 |
JJ |
denotes |
incalculable |
T6202 |
945-946 |
. |
denotes |
. |
T6203 |
946-1153 |
sentence |
denotes |
We suggest biallelic effects as a previously underestimated yet important variable in considering genotype–phenotype relationships from autosomal recessive disease to normal phenotypic diversity in mammals. |
T6204 |
947-949 |
PRP |
denotes |
We |
T6205 |
950-957 |
VBP |
denotes |
suggest |
T6206 |
958-967 |
JJ |
denotes |
biallelic |
T6207 |
968-975 |
NNS |
denotes |
effects |
T6208 |
976-978 |
IN |
denotes |
as |
T6209 |
979-980 |
DT |
denotes |
a |
T6210 |
1021-1029 |
NN |
denotes |
variable |
T6211 |
981-991 |
RB |
denotes |
previously |
T6212 |
992-1006 |
VBN |
denotes |
underestimated |
T6213 |
1011-1020 |
JJ |
denotes |
important |
T6214 |
1007-1010 |
RB |
denotes |
yet |
T6215 |
1030-1032 |
IN |
denotes |
in |
T6216 |
1033-1044 |
VBG |
denotes |
considering |
T6217 |
1045-1053 |
NN |
denotes |
genotype |
T6218 |
1054-1063 |
NN |
denotes |
phenotype |
T6219 |
1053-1054 |
HYPH |
denotes |
– |
T6220 |
1064-1077 |
NNS |
denotes |
relationships |
T6221 |
1078-1082 |
IN |
denotes |
from |
T6222 |
1083-1092 |
JJ |
denotes |
autosomal |
T6223 |
1103-1110 |
NN |
denotes |
disease |
T6224 |
1093-1102 |
JJ |
denotes |
recessive |
T6225 |
1111-1113 |
IN |
denotes |
to |
T6226 |
1114-1120 |
JJ |
denotes |
normal |
T6227 |
1132-1141 |
NN |
denotes |
diversity |
T6228 |
1121-1131 |
JJ |
denotes |
phenotypic |
T6229 |
1142-1144 |
IN |
denotes |
in |
T6230 |
1145-1152 |
NNS |
denotes |
mammals |
T6231 |
1152-1153 |
. |
denotes |
. |
T6232 |
1153-1330 |
sentence |
denotes |
Extension of the above concept implies that recessive mutations can enter evolutionary selection in F1 provided that the second allele carries a different recessive alteration. |
T6233 |
1154-1163 |
NN |
denotes |
Extension |
T6234 |
1185-1192 |
VBZ |
denotes |
implies |
T6235 |
1164-1166 |
IN |
denotes |
of |
T6236 |
1167-1170 |
DT |
denotes |
the |
T6237 |
1177-1184 |
NN |
denotes |
concept |
T6238 |
1171-1176 |
JJ |
denotes |
above |
T6239 |
1193-1197 |
IN |
denotes |
that |
T6240 |
1222-1227 |
VB |
denotes |
enter |
T6241 |
1198-1207 |
JJ |
denotes |
recessive |
T6242 |
1208-1217 |
NNS |
denotes |
mutations |
T6243 |
1218-1221 |
MD |
denotes |
can |
T6244 |
1228-1240 |
JJ |
denotes |
evolutionary |
T6245 |
1241-1250 |
NN |
denotes |
selection |
T6246 |
1251-1253 |
IN |
denotes |
in |
T6247 |
1254-1256 |
NN |
denotes |
F1 |
T6248 |
1257-1265 |
VBN |
denotes |
provided |
T6249 |
1266-1270 |
IN |
denotes |
that |
T6250 |
1289-1296 |
VBZ |
denotes |
carries |
T6251 |
1271-1274 |
DT |
denotes |
the |
T6252 |
1282-1288 |
NN |
denotes |
allele |
T6253 |
1275-1281 |
JJ |
denotes |
second |
T6254 |
1297-1298 |
DT |
denotes |
a |
T6255 |
1319-1329 |
NN |
denotes |
alteration |
T6256 |
1299-1308 |
JJ |
denotes |
different |
T6257 |
1309-1318 |
JJ |
denotes |
recessive |
T6258 |
1329-1330 |
. |
denotes |
. |
T6259 |
1330-1527 |
sentence |
denotes |
Finally, our data highlight the potential of clinically relevant alleles previously designated as null, with little or no detectable expression or activity, to nonetheless contribute to phenotype. |
T6260 |
1331-1338 |
RB |
denotes |
Finally |
T6261 |
1349-1358 |
VBP |
denotes |
highlight |
T6262 |
1338-1340 |
, |
denotes |
, |
T6263 |
1340-1343 |
PRP$ |
denotes |
our |
T6264 |
1344-1348 |
NNS |
denotes |
data |
T6265 |
1359-1362 |
DT |
denotes |
the |
T6266 |
1363-1372 |
NN |
denotes |
potential |
T6267 |
1373-1375 |
IN |
denotes |
of |
T6268 |
1376-1386 |
RB |
denotes |
clinically |
T6269 |
1387-1395 |
JJ |
denotes |
relevant |
T6270 |
1396-1403 |
NNS |
denotes |
alleles |
T6271 |
1404-1414 |
RB |
denotes |
previously |
T6272 |
1415-1425 |
VBN |
denotes |
designated |
T6273 |
1426-1428 |
IN |
denotes |
as |
T6274 |
1429-1433 |
JJ |
denotes |
null |
T6275 |
1433-1435 |
, |
denotes |
, |
T6276 |
1435-1439 |
IN |
denotes |
with |
T6277 |
1440-1446 |
JJ |
denotes |
little |
T6278 |
1464-1474 |
NN |
denotes |
expression |
T6279 |
1447-1449 |
CC |
denotes |
or |
T6280 |
1450-1452 |
DT |
denotes |
no |
T6281 |
1453-1463 |
JJ |
denotes |
detectable |
T6282 |
1475-1477 |
CC |
denotes |
or |
T6283 |
1478-1486 |
NN |
denotes |
activity |
T6284 |
1486-1488 |
, |
denotes |
, |
T6285 |
1488-1490 |
TO |
denotes |
to |
T6286 |
1503-1513 |
VB |
denotes |
contribute |
T6287 |
1491-1502 |
RB |
denotes |
nonetheless |
T6288 |
1514-1516 |
IN |
denotes |
to |
T6289 |
1517-1526 |
NN |
denotes |
phenotype |
T6290 |
1526-1527 |
. |
denotes |
. |
R4110 |
T6053 |
T6054 |
prep |
In,remains |
R4111 |
T6055 |
T6053 |
pobj |
humans,In |
R4112 |
T6056 |
T6054 |
punct |
", ",remains |
R4113 |
T6057 |
T6058 |
det |
the,relevance |
R4114 |
T6058 |
T6054 |
nsubj |
relevance,remains |
R4115 |
T6059 |
T6058 |
amod |
clinical,relevance |
R4116 |
T6060 |
T6058 |
prep |
of,relevance |
R4117 |
T6061 |
T6062 |
amod |
biallelic,effects |
R4118 |
T6062 |
T6060 |
pobj |
effects,of |
R4119 |
T6063 |
T6064 |
amod |
such,as |
R4120 |
T6064 |
T6062 |
prep |
as,effects |
R4121 |
T6065 |
T6066 |
amod |
interallelic,complementation |
R4122 |
T6066 |
T6064 |
pobj |
complementation,as |
R4123 |
T6067 |
T6054 |
acomp |
unknown,remains |
R4124 |
T6068 |
T6054 |
punct |
.,remains |
R4125 |
T6070 |
T6071 |
mark |
Although,described |
R4126 |
T6071 |
T6081 |
advcl |
described,noted |
R4127 |
T6072 |
T6073 |
amod |
interallelic,complementation |
R4128 |
T6073 |
T6071 |
nsubjpass |
complementation,described |
R4129 |
T6074 |
T6073 |
prep |
between,complementation |
R4130 |
T6075 |
T6076 |
nummod |
two,alleles |
R4131 |
T6076 |
T6074 |
pobj |
alleles,between |
R4132 |
T6077 |
T6076 |
amod |
endogenous,alleles |
R4133 |
T6078 |
T6076 |
amod |
mutant,alleles |
R4134 |
T6079 |
T6071 |
aux |
has,described |
R4135 |
T6080 |
T6071 |
auxpass |
been,described |
R4136 |
T6082 |
T6071 |
prep |
in,described |
R4137 |
T6083 |
T6082 |
pobj |
cells,in |
R4138 |
T6084 |
T6083 |
prep |
from,cells |
R4139 |
T6085 |
T6086 |
det |
a,patient |
R4140 |
T6086 |
T6084 |
pobj |
patient,from |
R4141 |
T6087 |
T6086 |
nmod |
compound,patient |
R4142 |
T6088 |
T6086 |
amod |
heterozygous,patient |
R4143 |
T6089 |
T6086 |
prep |
with,patient |
R4144 |
T6090 |
T6091 |
amod |
methylmalonic,acidaemia |
R4145 |
T6091 |
T6089 |
pobj |
acidaemia,with |
R4146 |
T6092 |
T6081 |
punct |
", ",noted |
R4147 |
T6093 |
T6094 |
det |
no,effects |
R4148 |
T6094 |
T6081 |
nsubjpass |
effects,noted |
R4149 |
T6095 |
T6094 |
amod |
observable,effects |
R4150 |
T6096 |
T6094 |
prep |
on,effects |
R4151 |
T6097 |
T6098 |
compound |
disease,outcome |
R4152 |
T6098 |
T6096 |
pobj |
outcome,on |
R4153 |
T6099 |
T6081 |
auxpass |
were,noted |
R4154 |
T6100 |
T6081 |
prep |
in,noted |
R4155 |
T6101 |
T6102 |
det |
the,patient |
R4156 |
T6102 |
T6100 |
pobj |
patient,in |
R4157 |
T6103 |
T6104 |
punct |
[,28 |
R4158 |
T6104 |
T6081 |
parataxis |
28,noted |
R4159 |
T6105 |
T6104 |
punct |
],28 |
R4160 |
T6106 |
T6081 |
punct |
.,noted |
R4161 |
T6108 |
T6109 |
advmod |
Thus,is |
R4162 |
T6110 |
T6109 |
punct |
", ",is |
R4163 |
T6111 |
T6109 |
prep |
to,is |
R4164 |
T6112 |
T6113 |
det |
the,best |
R4165 |
T6113 |
T6111 |
pobj |
best,to |
R4166 |
T6114 |
T6113 |
prep |
of,best |
R4167 |
T6115 |
T6116 |
poss |
our,knowledge |
R4168 |
T6116 |
T6114 |
pobj |
knowledge,of |
R4169 |
T6117 |
T6109 |
punct |
", ",is |
R4170 |
T6118 |
T6119 |
det |
the,amelioration |
R4171 |
T6119 |
T6109 |
nsubj |
amelioration,is |
R4172 |
T6120 |
T6119 |
prep |
of,amelioration |
R4173 |
T6121 |
T6122 |
amod |
progeroid,features |
R4174 |
T6122 |
T6120 |
pobj |
features,of |
R4175 |
T6123 |
T6119 |
acl |
observed,amelioration |
R4176 |
T6124 |
T6123 |
advmod |
here,observed |
R4177 |
T6125 |
T6126 |
det |
the,demonstration |
R4178 |
T6126 |
T6109 |
attr |
demonstration,is |
R4179 |
T6127 |
T6126 |
amod |
first,demonstration |
R4180 |
T6128 |
T6129 |
advmod |
in,vivo |
R4181 |
T6129 |
T6126 |
amod |
vivo,demonstration |
R4182 |
T6130 |
T6126 |
prep |
in,demonstration |
R4183 |
T6131 |
T6132 |
nmod |
compound,animals |
R4184 |
T6132 |
T6130 |
pobj |
animals,in |
R4185 |
T6133 |
T6132 |
amod |
heterozygous,animals |
R4186 |
T6134 |
T6132 |
prep |
of,animals |
R4187 |
T6135 |
T6136 |
amod |
interallelic,complementation |
R4188 |
T6136 |
T6134 |
pobj |
complementation,of |
R4189 |
T6137 |
T6126 |
amod |
relevant,demonstration |
R4190 |
T6138 |
T6137 |
prep |
to,relevant |
R4191 |
T6139 |
T6140 |
det |
a,disease |
R4192 |
T6140 |
T6138 |
pobj |
disease,to |
R4193 |
T6141 |
T6140 |
amod |
human,disease |
R4194 |
T6142 |
T6109 |
punct |
.,is |
R4195 |
T6144 |
T6145 |
advcl |
Keeping,is |
R4196 |
T6146 |
T6144 |
prep |
in,Keeping |
R4197 |
T6147 |
T6146 |
pobj |
mind,in |
R4198 |
T6148 |
T6149 |
mark |
that,result |
R4199 |
T6149 |
T6144 |
ccomp |
result,Keeping |
R4200 |
T6150 |
T6151 |
det |
the,alleles |
R4201 |
T6151 |
T6149 |
nsubj |
alleles,result |
R4202 |
T6152 |
T6153 |
punct |
~,"1,200" |
R4203 |
T6153 |
T6151 |
nummod |
"1,200",alleles |
R4204 |
T6154 |
T6151 |
acl |
known,alleles |
R4205 |
T6155 |
T6156 |
aux |
to,exist |
R4206 |
T6156 |
T6154 |
xcomp |
exist,known |
R4207 |
T6157 |
T6156 |
prep |
for,exist |
R4208 |
T6158 |
T6159 |
det |
the,gene |
R4209 |
T6159 |
T6157 |
pobj |
gene,for |
R4210 |
T6160 |
T6159 |
compound |
CTRF,gene |
R4211 |
T6161 |
T6159 |
acl |
implicated,gene |
R4212 |
T6162 |
T6161 |
prep |
in,implicated |
R4213 |
T6163 |
T6164 |
det |
the,disorder |
R4214 |
T6164 |
T6162 |
pobj |
disorder,in |
R4215 |
T6165 |
T6164 |
amod |
common,disorder |
R4216 |
T6166 |
T6164 |
amod |
autosomal,disorder |
R4217 |
T6167 |
T6164 |
amod |
recessive,disorder |
R4218 |
T6168 |
T6169 |
amod |
cystic,fibrosis |
R4219 |
T6169 |
T6164 |
appos |
fibrosis,disorder |
R4220 |
T6170 |
T6161 |
advmod |
alone,implicated |
R4221 |
T6171 |
T6172 |
punct |
[,29 |
R4222 |
T6172 |
T6154 |
parataxis |
29,known |
R4223 |
T6173 |
T6172 |
punct |
],29 |
R4224 |
T6174 |
T6149 |
aux |
can,result |
R4225 |
T6175 |
T6149 |
advmod |
theoretically,result |
R4226 |
T6176 |
T6149 |
prep |
in,result |
R4227 |
T6177 |
T6178 |
punct |
~,"700,000" |
R4228 |
T6178 |
T6179 |
nummod |
"700,000",combinations |
R4229 |
T6179 |
T6176 |
pobj |
combinations,in |
R4230 |
T6180 |
T6179 |
amod |
different,combinations |
R4231 |
T6181 |
T6179 |
amod |
allelic,combinations |
R4232 |
T6182 |
T6145 |
punct |
", ",is |
R4233 |
T6183 |
T6184 |
det |
the,number |
R4234 |
T6184 |
T6145 |
nsubj |
number,is |
R4235 |
T6185 |
T6184 |
amod |
potential,number |
R4236 |
T6186 |
T6184 |
prep |
of,number |
R4237 |
T6187 |
T6188 |
amod |
allelic,combinations |
R4238 |
T6188 |
T6186 |
pobj |
combinations,of |
R4239 |
T6189 |
T6188 |
prep |
of,combinations |
R4240 |
T6190 |
T6191 |
amod |
different,mutations |
R4241 |
T6191 |
T6189 |
pobj |
mutations,of |
R4242 |
T6192 |
T6191 |
amod |
recessive,mutations |
R4243 |
T6193 |
T6191 |
cc |
and,mutations |
R4244 |
T6194 |
T6195 |
amod |
single,polymorphisms |
R4245 |
T6195 |
T6191 |
conj |
polymorphisms,mutations |
R4246 |
T6196 |
T6195 |
compound |
nucleotide,polymorphisms |
R4247 |
T6197 |
T6198 |
npadvmod |
genome,wide |
R4248 |
T6198 |
T6184 |
amod |
wide,number |
R4249 |
T6199 |
T6198 |
punct |
-,wide |
R4250 |
T6200 |
T6145 |
advmod |
currently,is |
R4251 |
T6201 |
T6145 |
acomp |
incalculable,is |
R4252 |
T6202 |
T6145 |
punct |
.,is |
R4253 |
T6204 |
T6205 |
nsubj |
We,suggest |
R4254 |
T6206 |
T6207 |
amod |
biallelic,effects |
R4255 |
T6207 |
T6205 |
dobj |
effects,suggest |
R4256 |
T6208 |
T6205 |
prep |
as,suggest |
R4257 |
T6209 |
T6210 |
det |
a,variable |
R4258 |
T6210 |
T6208 |
pobj |
variable,as |
R4259 |
T6211 |
T6212 |
advmod |
previously,underestimated |
R4260 |
T6212 |
T6213 |
amod |
underestimated,important |
R4261 |
T6213 |
T6210 |
amod |
important,variable |
R4262 |
T6214 |
T6213 |
advmod |
yet,important |
R4263 |
T6215 |
T6205 |
prep |
in,suggest |
R4264 |
T6216 |
T6215 |
pcomp |
considering,in |
R4265 |
T6217 |
T6218 |
compound |
genotype,phenotype |
R4266 |
T6218 |
T6220 |
compound |
phenotype,relationships |
R4267 |
T6219 |
T6218 |
punct |
–,phenotype |
R4268 |
T6220 |
T6216 |
dobj |
relationships,considering |
R4269 |
T6221 |
T6216 |
prep |
from,considering |
R4270 |
T6222 |
T6223 |
amod |
autosomal,disease |
R4271 |
T6223 |
T6221 |
pobj |
disease,from |
R4272 |
T6224 |
T6223 |
amod |
recessive,disease |
R4273 |
T6225 |
T6221 |
prep |
to,from |
R4274 |
T6226 |
T6227 |
amod |
normal,diversity |
R4275 |
T6227 |
T6225 |
pobj |
diversity,to |
R4276 |
T6228 |
T6227 |
amod |
phenotypic,diversity |
R4277 |
T6229 |
T6216 |
prep |
in,considering |
R4278 |
T6230 |
T6229 |
pobj |
mammals,in |
R4279 |
T6231 |
T6205 |
punct |
.,suggest |
R4280 |
T6233 |
T6234 |
nsubj |
Extension,implies |
R4281 |
T6235 |
T6233 |
prep |
of,Extension |
R4282 |
T6236 |
T6237 |
det |
the,concept |
R4283 |
T6237 |
T6235 |
pobj |
concept,of |
R4284 |
T6238 |
T6237 |
amod |
above,concept |
R4285 |
T6239 |
T6240 |
mark |
that,enter |
R4286 |
T6240 |
T6234 |
ccomp |
enter,implies |
R4287 |
T6241 |
T6242 |
amod |
recessive,mutations |
R4288 |
T6242 |
T6240 |
nsubj |
mutations,enter |
R4289 |
T6243 |
T6240 |
aux |
can,enter |
R4290 |
T6244 |
T6245 |
amod |
evolutionary,selection |
R4291 |
T6245 |
T6240 |
dobj |
selection,enter |
R4292 |
T6246 |
T6240 |
prep |
in,enter |
R4293 |
T6247 |
T6246 |
pobj |
F1,in |
R4294 |
T6248 |
T6240 |
prep |
provided,enter |
R4295 |
T6249 |
T6250 |
mark |
that,carries |
R4296 |
T6250 |
T6248 |
pcomp |
carries,provided |
R4297 |
T6251 |
T6252 |
det |
the,allele |
R4298 |
T6252 |
T6250 |
nsubj |
allele,carries |
R4299 |
T6253 |
T6252 |
amod |
second,allele |
R4300 |
T6254 |
T6255 |
det |
a,alteration |
R4301 |
T6255 |
T6250 |
dobj |
alteration,carries |
R4302 |
T6256 |
T6255 |
amod |
different,alteration |
R4303 |
T6257 |
T6255 |
amod |
recessive,alteration |
R4304 |
T6258 |
T6234 |
punct |
.,implies |
R4305 |
T6260 |
T6261 |
advmod |
Finally,highlight |
R4306 |
T6262 |
T6261 |
punct |
", ",highlight |
R4307 |
T6263 |
T6264 |
poss |
our,data |
R4308 |
T6264 |
T6261 |
nsubj |
data,highlight |
R4309 |
T6265 |
T6266 |
det |
the,potential |
R4310 |
T6266 |
T6261 |
dobj |
potential,highlight |
R4311 |
T6267 |
T6266 |
prep |
of,potential |
R4312 |
T6268 |
T6269 |
advmod |
clinically,relevant |
R4313 |
T6269 |
T6270 |
amod |
relevant,alleles |
R4314 |
T6270 |
T6267 |
pobj |
alleles,of |
R4315 |
T6271 |
T6272 |
advmod |
previously,designated |
R4316 |
T6272 |
T6270 |
acl |
designated,alleles |
R4317 |
T6273 |
T6272 |
prep |
as,designated |
R4318 |
T6274 |
T6273 |
amod |
null,as |
R4319 |
T6275 |
T6270 |
punct |
", ",alleles |
R4320 |
T6276 |
T6270 |
prep |
with,alleles |
R4321 |
T6277 |
T6278 |
amod |
little,expression |
R4322 |
T6278 |
T6276 |
pobj |
expression,with |
R4323 |
T6279 |
T6277 |
cc |
or,little |
R4324 |
T6280 |
T6277 |
conj |
no,little |
R4325 |
T6281 |
T6278 |
amod |
detectable,expression |
R4326 |
T6282 |
T6278 |
cc |
or,expression |
R4327 |
T6283 |
T6278 |
conj |
activity,expression |
R4328 |
T6284 |
T6266 |
punct |
", ",potential |
R4329 |
T6285 |
T6286 |
aux |
to,contribute |
R4330 |
T6286 |
T6266 |
acl |
contribute,potential |
R4331 |
T6287 |
T6286 |
advmod |
nonetheless,contribute |
R4332 |
T6288 |
T6286 |
prep |
to,contribute |
R4333 |
T6289 |
T6288 |
pobj |
phenotype,to |
R4334 |
T6290 |
T6261 |
punct |
.,highlight |