Id |
Subject |
Object |
Predicate |
Lexical cue |
T6041 |
0-9 |
NN |
denotes |
Potential |
T6042 |
10-12 |
IN |
denotes |
of |
T6043 |
13-21 |
VBN |
denotes |
Combined |
T6044 |
32-39 |
NNS |
denotes |
Alleles |
T6045 |
22-31 |
JJ |
denotes |
Recessive |
T6046 |
40-42 |
TO |
denotes |
to |
T6047 |
43-49 |
VB |
denotes |
Affect |
T6048 |
50-60 |
JJ |
denotes |
Phenotypic |
T6049 |
61-70 |
NN |
denotes |
Diversity |
T6050 |
71-73 |
IN |
denotes |
in |
T6051 |
74-81 |
NNS |
denotes |
Mammals |
T6052 |
81-190 |
sentence |
denotes |
In humans, the clinical relevance of biallelic effects such as interallelic complementation remains unknown. |
T6053 |
82-84 |
IN |
denotes |
In |
T6054 |
174-181 |
VBZ |
denotes |
remains |
T6055 |
85-91 |
NNS |
denotes |
humans |
T6056 |
91-93 |
, |
denotes |
, |
T6057 |
93-96 |
DT |
denotes |
the |
T6058 |
106-115 |
NN |
denotes |
relevance |
T6059 |
97-105 |
JJ |
denotes |
clinical |
T6060 |
116-118 |
IN |
denotes |
of |
T6061 |
119-128 |
JJ |
denotes |
biallelic |
T6062 |
129-136 |
NNS |
denotes |
effects |
T6063 |
137-141 |
JJ |
denotes |
such |
T6064 |
142-144 |
IN |
denotes |
as |
T6065 |
145-157 |
JJ |
denotes |
interallelic |
T6066 |
158-173 |
NN |
denotes |
complementation |
T6067 |
182-189 |
JJ |
denotes |
unknown |
T6068 |
189-190 |
. |
denotes |
. |
T6069 |
190-434 |
sentence |
denotes |
Although interallelic complementation between two endogenous mutant alleles has been described in cells from a compound heterozygous patient with methylmalonic acidaemia, no observable effects on disease outcome were noted in the patient [28]. |
T6070 |
191-199 |
IN |
denotes |
Although |
T6071 |
276-285 |
VBN |
denotes |
described |
T6072 |
200-212 |
JJ |
denotes |
interallelic |
T6073 |
213-228 |
NN |
denotes |
complementation |
T6074 |
229-236 |
IN |
denotes |
between |
T6075 |
237-240 |
CD |
denotes |
two |
T6076 |
259-266 |
NNS |
denotes |
alleles |
T6077 |
241-251 |
JJ |
denotes |
endogenous |
T6078 |
252-258 |
JJ |
denotes |
mutant |
T6079 |
267-270 |
VBZ |
denotes |
has |
T6080 |
271-275 |
VBN |
denotes |
been |
T6081 |
408-413 |
VBN |
denotes |
noted |
T6082 |
286-288 |
IN |
denotes |
in |
T6083 |
289-294 |
NNS |
denotes |
cells |
T6084 |
295-299 |
IN |
denotes |
from |
T6085 |
300-301 |
DT |
denotes |
a |
T6086 |
324-331 |
NN |
denotes |
patient |
T6087 |
302-310 |
NN |
denotes |
compound |
T6088 |
311-323 |
JJ |
denotes |
heterozygous |
T6089 |
332-336 |
IN |
denotes |
with |
T6090 |
337-350 |
JJ |
denotes |
methylmalonic |
T6091 |
351-360 |
NN |
denotes |
acidaemia |
T6092 |
360-362 |
, |
denotes |
, |
T6093 |
362-364 |
DT |
denotes |
no |
T6094 |
376-383 |
NNS |
denotes |
effects |
T6095 |
365-375 |
JJ |
denotes |
observable |
T6096 |
384-386 |
IN |
denotes |
on |
T6097 |
387-394 |
NN |
denotes |
disease |
T6098 |
395-402 |
NN |
denotes |
outcome |
T6099 |
403-407 |
VBD |
denotes |
were |
T6100 |
414-416 |
IN |
denotes |
in |
T6101 |
417-420 |
DT |
denotes |
the |
T6102 |
421-428 |
NN |
denotes |
patient |
T6103 |
429-430 |
-LRB- |
denotes |
[ |
T6104 |
430-432 |
CD |
denotes |
28 |
T6105 |
432-433 |
-RRB- |
denotes |
] |
T6106 |
433-434 |
. |
denotes |
. |
T6107 |
434-652 |
sentence |
denotes |
Thus, to the best of our knowledge, the amelioration of progeroid features observed here is the first in vivo demonstration in compound heterozygous animals of interallelic complementation relevant to a human disease. |
T6108 |
435-439 |
RB |
denotes |
Thus |
T6109 |
524-526 |
VBZ |
denotes |
is |
T6110 |
439-441 |
, |
denotes |
, |
T6111 |
441-443 |
IN |
denotes |
to |
T6112 |
444-447 |
DT |
denotes |
the |
T6113 |
448-452 |
JJS |
denotes |
best |
T6114 |
453-455 |
IN |
denotes |
of |
T6115 |
456-459 |
PRP$ |
denotes |
our |
T6116 |
460-469 |
NN |
denotes |
knowledge |
T6117 |
469-471 |
, |
denotes |
, |
T6118 |
471-474 |
DT |
denotes |
the |
T6119 |
475-487 |
NN |
denotes |
amelioration |
T6120 |
488-490 |
IN |
denotes |
of |
T6121 |
491-500 |
JJ |
denotes |
progeroid |
T6122 |
501-509 |
NNS |
denotes |
features |
T6123 |
510-518 |
VBN |
denotes |
observed |
T6124 |
519-523 |
RB |
denotes |
here |
T6125 |
527-530 |
DT |
denotes |
the |
T6126 |
545-558 |
NN |
denotes |
demonstration |
T6127 |
531-536 |
JJ |
denotes |
first |
T6128 |
537-539 |
FW |
denotes |
in |
T6129 |
540-544 |
FW |
denotes |
vivo |
T6130 |
559-561 |
IN |
denotes |
in |
T6131 |
562-570 |
NN |
denotes |
compound |
T6132 |
584-591 |
NNS |
denotes |
animals |
T6133 |
571-583 |
JJ |
denotes |
heterozygous |
T6134 |
592-594 |
IN |
denotes |
of |
T6135 |
595-607 |
JJ |
denotes |
interallelic |
T6136 |
608-623 |
NN |
denotes |
complementation |
T6137 |
624-632 |
JJ |
denotes |
relevant |
T6138 |
633-635 |
IN |
denotes |
to |
T6139 |
636-637 |
DT |
denotes |
a |
T6140 |
644-651 |
NN |
denotes |
disease |
T6141 |
638-643 |
JJ |
denotes |
human |
T6142 |
651-652 |
. |
denotes |
. |
T6143 |
652-1028 |
sentence |
denotes |
Keeping in mind that the ~1,200 alleles known to exist for the CTRF gene implicated in the common autosomal recessive disorder cystic fibrosis alone [29] can theoretically result in ~700,000 different allelic combinations, the potential number of allelic combinations of different recessive mutations and single nucleotide polymorphisms genome-wide is currently incalculable. |
T6144 |
653-660 |
VBG |
denotes |
Keeping |
T6145 |
1002-1004 |
VBZ |
denotes |
is |
T6146 |
661-663 |
IN |
denotes |
in |
T6147 |
664-668 |
NN |
denotes |
mind |
T6148 |
669-673 |
IN |
denotes |
that |
T6149 |
825-831 |
VB |
denotes |
result |
T6150 |
674-677 |
DT |
denotes |
the |
T6151 |
685-692 |
NNS |
denotes |
alleles |
T6152 |
678-679 |
SYM |
denotes |
~ |
T6153 |
679-684 |
CD |
denotes |
1,200 |
T6154 |
693-698 |
VBN |
denotes |
known |
T6155 |
699-701 |
TO |
denotes |
to |
T6156 |
702-707 |
VB |
denotes |
exist |
T6157 |
708-711 |
IN |
denotes |
for |
T6158 |
712-715 |
DT |
denotes |
the |
T6159 |
721-725 |
NN |
denotes |
gene |
T6160 |
716-720 |
NN |
denotes |
CTRF |
T6161 |
726-736 |
VBN |
denotes |
implicated |
T6162 |
737-739 |
IN |
denotes |
in |
T6163 |
740-743 |
DT |
denotes |
the |
T6164 |
771-779 |
NN |
denotes |
disorder |
T6165 |
744-750 |
JJ |
denotes |
common |
T6166 |
751-760 |
JJ |
denotes |
autosomal |
T6167 |
761-770 |
JJ |
denotes |
recessive |
T6168 |
780-786 |
JJ |
denotes |
cystic |
T6169 |
787-795 |
NN |
denotes |
fibrosis |
T6170 |
796-801 |
RB |
denotes |
alone |
T6171 |
802-803 |
-LRB- |
denotes |
[ |
T6172 |
803-805 |
CD |
denotes |
29 |
T6173 |
805-806 |
-RRB- |
denotes |
] |
T6174 |
807-810 |
MD |
denotes |
can |
T6175 |
811-824 |
RB |
denotes |
theoretically |
T6176 |
832-834 |
IN |
denotes |
in |
T6177 |
835-836 |
SYM |
denotes |
~ |
T6178 |
836-843 |
CD |
denotes |
700,000 |
T6179 |
862-874 |
NNS |
denotes |
combinations |
T6180 |
844-853 |
JJ |
denotes |
different |
T6181 |
854-861 |
JJ |
denotes |
allelic |
T6182 |
874-876 |
, |
denotes |
, |
T6183 |
876-879 |
DT |
denotes |
the |
T6184 |
890-896 |
NN |
denotes |
number |
T6185 |
880-889 |
JJ |
denotes |
potential |
T6186 |
897-899 |
IN |
denotes |
of |
T6187 |
900-907 |
JJ |
denotes |
allelic |
T6188 |
908-920 |
NNS |
denotes |
combinations |
T6189 |
921-923 |
IN |
denotes |
of |
T6190 |
924-933 |
JJ |
denotes |
different |
T6191 |
944-953 |
NNS |
denotes |
mutations |
T6192 |
934-943 |
JJ |
denotes |
recessive |
T6193 |
954-957 |
CC |
denotes |
and |
T6194 |
958-964 |
JJ |
denotes |
single |
T6195 |
976-989 |
NNS |
denotes |
polymorphisms |
T6196 |
965-975 |
NN |
denotes |
nucleotide |
T6197 |
990-996 |
NN |
denotes |
genome |
T6198 |
997-1001 |
JJ |
denotes |
wide |
T6199 |
996-997 |
HYPH |
denotes |
- |
T6200 |
1005-1014 |
RB |
denotes |
currently |
T6201 |
1015-1027 |
JJ |
denotes |
incalculable |
T6202 |
1027-1028 |
. |
denotes |
. |
T6203 |
1028-1235 |
sentence |
denotes |
We suggest biallelic effects as a previously underestimated yet important variable in considering genotype–phenotype relationships from autosomal recessive disease to normal phenotypic diversity in mammals. |
T6204 |
1029-1031 |
PRP |
denotes |
We |
T6205 |
1032-1039 |
VBP |
denotes |
suggest |
T6206 |
1040-1049 |
JJ |
denotes |
biallelic |
T6207 |
1050-1057 |
NNS |
denotes |
effects |
T6208 |
1058-1060 |
IN |
denotes |
as |
T6209 |
1061-1062 |
DT |
denotes |
a |
T6210 |
1103-1111 |
NN |
denotes |
variable |
T6211 |
1063-1073 |
RB |
denotes |
previously |
T6212 |
1074-1088 |
VBN |
denotes |
underestimated |
T6213 |
1093-1102 |
JJ |
denotes |
important |
T6214 |
1089-1092 |
RB |
denotes |
yet |
T6215 |
1112-1114 |
IN |
denotes |
in |
T6216 |
1115-1126 |
VBG |
denotes |
considering |
T6217 |
1127-1135 |
NN |
denotes |
genotype |
T6218 |
1136-1145 |
NN |
denotes |
phenotype |
T6219 |
1135-1136 |
HYPH |
denotes |
– |
T6220 |
1146-1159 |
NNS |
denotes |
relationships |
T6221 |
1160-1164 |
IN |
denotes |
from |
T6222 |
1165-1174 |
JJ |
denotes |
autosomal |
T6223 |
1185-1192 |
NN |
denotes |
disease |
T6224 |
1175-1184 |
JJ |
denotes |
recessive |
T6225 |
1193-1195 |
IN |
denotes |
to |
T6226 |
1196-1202 |
JJ |
denotes |
normal |
T6227 |
1214-1223 |
NN |
denotes |
diversity |
T6228 |
1203-1213 |
JJ |
denotes |
phenotypic |
T6229 |
1224-1226 |
IN |
denotes |
in |
T6230 |
1227-1234 |
NNS |
denotes |
mammals |
T6231 |
1234-1235 |
. |
denotes |
. |
T6232 |
1235-1412 |
sentence |
denotes |
Extension of the above concept implies that recessive mutations can enter evolutionary selection in F1 provided that the second allele carries a different recessive alteration. |
T6233 |
1236-1245 |
NN |
denotes |
Extension |
T6234 |
1267-1274 |
VBZ |
denotes |
implies |
T6235 |
1246-1248 |
IN |
denotes |
of |
T6236 |
1249-1252 |
DT |
denotes |
the |
T6237 |
1259-1266 |
NN |
denotes |
concept |
T6238 |
1253-1258 |
JJ |
denotes |
above |
T6239 |
1275-1279 |
IN |
denotes |
that |
T6240 |
1304-1309 |
VB |
denotes |
enter |
T6241 |
1280-1289 |
JJ |
denotes |
recessive |
T6242 |
1290-1299 |
NNS |
denotes |
mutations |
T6243 |
1300-1303 |
MD |
denotes |
can |
T6244 |
1310-1322 |
JJ |
denotes |
evolutionary |
T6245 |
1323-1332 |
NN |
denotes |
selection |
T6246 |
1333-1335 |
IN |
denotes |
in |
T6247 |
1336-1338 |
NN |
denotes |
F1 |
T6248 |
1339-1347 |
VBN |
denotes |
provided |
T6249 |
1348-1352 |
IN |
denotes |
that |
T6250 |
1371-1378 |
VBZ |
denotes |
carries |
T6251 |
1353-1356 |
DT |
denotes |
the |
T6252 |
1364-1370 |
NN |
denotes |
allele |
T6253 |
1357-1363 |
JJ |
denotes |
second |
T6254 |
1379-1380 |
DT |
denotes |
a |
T6255 |
1401-1411 |
NN |
denotes |
alteration |
T6256 |
1381-1390 |
JJ |
denotes |
different |
T6257 |
1391-1400 |
JJ |
denotes |
recessive |
T6258 |
1411-1412 |
. |
denotes |
. |
T6259 |
1412-1609 |
sentence |
denotes |
Finally, our data highlight the potential of clinically relevant alleles previously designated as null, with little or no detectable expression or activity, to nonetheless contribute to phenotype. |
T6260 |
1413-1420 |
RB |
denotes |
Finally |
T6261 |
1431-1440 |
VBP |
denotes |
highlight |
T6262 |
1420-1422 |
, |
denotes |
, |
T6263 |
1422-1425 |
PRP$ |
denotes |
our |
T6264 |
1426-1430 |
NNS |
denotes |
data |
T6265 |
1441-1444 |
DT |
denotes |
the |
T6266 |
1445-1454 |
NN |
denotes |
potential |
T6267 |
1455-1457 |
IN |
denotes |
of |
T6268 |
1458-1468 |
RB |
denotes |
clinically |
T6269 |
1469-1477 |
JJ |
denotes |
relevant |
T6270 |
1478-1485 |
NNS |
denotes |
alleles |
T6271 |
1486-1496 |
RB |
denotes |
previously |
T6272 |
1497-1507 |
VBN |
denotes |
designated |
T6273 |
1508-1510 |
IN |
denotes |
as |
T6274 |
1511-1515 |
JJ |
denotes |
null |
T6275 |
1515-1517 |
, |
denotes |
, |
T6276 |
1517-1521 |
IN |
denotes |
with |
T6277 |
1522-1528 |
JJ |
denotes |
little |
T6278 |
1546-1556 |
NN |
denotes |
expression |
T6279 |
1529-1531 |
CC |
denotes |
or |
T6280 |
1532-1534 |
DT |
denotes |
no |
T6281 |
1535-1545 |
JJ |
denotes |
detectable |
T6282 |
1557-1559 |
CC |
denotes |
or |
T6283 |
1560-1568 |
NN |
denotes |
activity |
T6284 |
1568-1570 |
, |
denotes |
, |
T6285 |
1570-1572 |
TO |
denotes |
to |
T6286 |
1585-1595 |
VB |
denotes |
contribute |
T6287 |
1573-1584 |
RB |
denotes |
nonetheless |
T6288 |
1596-1598 |
IN |
denotes |
to |
T6289 |
1599-1608 |
NN |
denotes |
phenotype |
T6290 |
1608-1609 |
. |
denotes |
. |
R4100 |
T6042 |
T6041 |
prep |
of,Potential |
R4101 |
T6043 |
T6044 |
amod |
Combined,Alleles |
R4102 |
T6044 |
T6042 |
pobj |
Alleles,of |
R4103 |
T6045 |
T6044 |
amod |
Recessive,Alleles |
R4104 |
T6046 |
T6047 |
aux |
to,Affect |
R4105 |
T6047 |
T6041 |
acl |
Affect,Potential |
R4106 |
T6048 |
T6049 |
amod |
Phenotypic,Diversity |
R4107 |
T6049 |
T6047 |
dobj |
Diversity,Affect |
R4108 |
T6050 |
T6047 |
prep |
in,Affect |
R4109 |
T6051 |
T6050 |
pobj |
Mammals,in |
R4110 |
T6053 |
T6054 |
prep |
In,remains |
R4111 |
T6055 |
T6053 |
pobj |
humans,In |
R4112 |
T6056 |
T6054 |
punct |
", ",remains |
R4113 |
T6057 |
T6058 |
det |
the,relevance |
R4114 |
T6058 |
T6054 |
nsubj |
relevance,remains |
R4115 |
T6059 |
T6058 |
amod |
clinical,relevance |
R4116 |
T6060 |
T6058 |
prep |
of,relevance |
R4117 |
T6061 |
T6062 |
amod |
biallelic,effects |
R4118 |
T6062 |
T6060 |
pobj |
effects,of |
R4119 |
T6063 |
T6064 |
amod |
such,as |
R4120 |
T6064 |
T6062 |
prep |
as,effects |
R4121 |
T6065 |
T6066 |
amod |
interallelic,complementation |
R4122 |
T6066 |
T6064 |
pobj |
complementation,as |
R4123 |
T6067 |
T6054 |
acomp |
unknown,remains |
R4124 |
T6068 |
T6054 |
punct |
.,remains |
R4125 |
T6070 |
T6071 |
mark |
Although,described |
R4126 |
T6071 |
T6081 |
advcl |
described,noted |
R4127 |
T6072 |
T6073 |
amod |
interallelic,complementation |
R4128 |
T6073 |
T6071 |
nsubjpass |
complementation,described |
R4129 |
T6074 |
T6073 |
prep |
between,complementation |
R4130 |
T6075 |
T6076 |
nummod |
two,alleles |
R4131 |
T6076 |
T6074 |
pobj |
alleles,between |
R4132 |
T6077 |
T6076 |
amod |
endogenous,alleles |
R4133 |
T6078 |
T6076 |
amod |
mutant,alleles |
R4134 |
T6079 |
T6071 |
aux |
has,described |
R4135 |
T6080 |
T6071 |
auxpass |
been,described |
R4136 |
T6082 |
T6071 |
prep |
in,described |
R4137 |
T6083 |
T6082 |
pobj |
cells,in |
R4138 |
T6084 |
T6083 |
prep |
from,cells |
R4139 |
T6085 |
T6086 |
det |
a,patient |
R4140 |
T6086 |
T6084 |
pobj |
patient,from |
R4141 |
T6087 |
T6086 |
nmod |
compound,patient |
R4142 |
T6088 |
T6086 |
amod |
heterozygous,patient |
R4143 |
T6089 |
T6086 |
prep |
with,patient |
R4144 |
T6090 |
T6091 |
amod |
methylmalonic,acidaemia |
R4145 |
T6091 |
T6089 |
pobj |
acidaemia,with |
R4146 |
T6092 |
T6081 |
punct |
", ",noted |
R4147 |
T6093 |
T6094 |
det |
no,effects |
R4148 |
T6094 |
T6081 |
nsubjpass |
effects,noted |
R4149 |
T6095 |
T6094 |
amod |
observable,effects |
R4150 |
T6096 |
T6094 |
prep |
on,effects |
R4151 |
T6097 |
T6098 |
compound |
disease,outcome |
R4152 |
T6098 |
T6096 |
pobj |
outcome,on |
R4153 |
T6099 |
T6081 |
auxpass |
were,noted |
R4154 |
T6100 |
T6081 |
prep |
in,noted |
R4155 |
T6101 |
T6102 |
det |
the,patient |
R4156 |
T6102 |
T6100 |
pobj |
patient,in |
R4157 |
T6103 |
T6104 |
punct |
[,28 |
R4158 |
T6104 |
T6081 |
parataxis |
28,noted |
R4159 |
T6105 |
T6104 |
punct |
],28 |
R4160 |
T6106 |
T6081 |
punct |
.,noted |
R4161 |
T6108 |
T6109 |
advmod |
Thus,is |
R4162 |
T6110 |
T6109 |
punct |
", ",is |
R4163 |
T6111 |
T6109 |
prep |
to,is |
R4164 |
T6112 |
T6113 |
det |
the,best |
R4165 |
T6113 |
T6111 |
pobj |
best,to |
R4166 |
T6114 |
T6113 |
prep |
of,best |
R4167 |
T6115 |
T6116 |
poss |
our,knowledge |
R4168 |
T6116 |
T6114 |
pobj |
knowledge,of |
R4169 |
T6117 |
T6109 |
punct |
", ",is |
R4170 |
T6118 |
T6119 |
det |
the,amelioration |
R4171 |
T6119 |
T6109 |
nsubj |
amelioration,is |
R4172 |
T6120 |
T6119 |
prep |
of,amelioration |
R4173 |
T6121 |
T6122 |
amod |
progeroid,features |
R4174 |
T6122 |
T6120 |
pobj |
features,of |
R4175 |
T6123 |
T6119 |
acl |
observed,amelioration |
R4176 |
T6124 |
T6123 |
advmod |
here,observed |
R4177 |
T6125 |
T6126 |
det |
the,demonstration |
R4178 |
T6126 |
T6109 |
attr |
demonstration,is |
R4179 |
T6127 |
T6126 |
amod |
first,demonstration |
R4180 |
T6128 |
T6129 |
advmod |
in,vivo |
R4181 |
T6129 |
T6126 |
amod |
vivo,demonstration |
R4182 |
T6130 |
T6126 |
prep |
in,demonstration |
R4183 |
T6131 |
T6132 |
nmod |
compound,animals |
R4184 |
T6132 |
T6130 |
pobj |
animals,in |
R4185 |
T6133 |
T6132 |
amod |
heterozygous,animals |
R4186 |
T6134 |
T6132 |
prep |
of,animals |
R4187 |
T6135 |
T6136 |
amod |
interallelic,complementation |
R4188 |
T6136 |
T6134 |
pobj |
complementation,of |
R4189 |
T6137 |
T6126 |
amod |
relevant,demonstration |
R4190 |
T6138 |
T6137 |
prep |
to,relevant |
R4191 |
T6139 |
T6140 |
det |
a,disease |
R4192 |
T6140 |
T6138 |
pobj |
disease,to |
R4193 |
T6141 |
T6140 |
amod |
human,disease |
R4194 |
T6142 |
T6109 |
punct |
.,is |
R4195 |
T6144 |
T6145 |
advcl |
Keeping,is |
R4196 |
T6146 |
T6144 |
prep |
in,Keeping |
R4197 |
T6147 |
T6146 |
pobj |
mind,in |
R4198 |
T6148 |
T6149 |
mark |
that,result |
R4199 |
T6149 |
T6144 |
ccomp |
result,Keeping |
R4200 |
T6150 |
T6151 |
det |
the,alleles |
R4201 |
T6151 |
T6149 |
nsubj |
alleles,result |
R4202 |
T6152 |
T6153 |
punct |
~,"1,200" |
R4203 |
T6153 |
T6151 |
nummod |
"1,200",alleles |
R4204 |
T6154 |
T6151 |
acl |
known,alleles |
R4205 |
T6155 |
T6156 |
aux |
to,exist |
R4206 |
T6156 |
T6154 |
xcomp |
exist,known |
R4207 |
T6157 |
T6156 |
prep |
for,exist |
R4208 |
T6158 |
T6159 |
det |
the,gene |
R4209 |
T6159 |
T6157 |
pobj |
gene,for |
R4210 |
T6160 |
T6159 |
compound |
CTRF,gene |
R4211 |
T6161 |
T6159 |
acl |
implicated,gene |
R4212 |
T6162 |
T6161 |
prep |
in,implicated |
R4213 |
T6163 |
T6164 |
det |
the,disorder |
R4214 |
T6164 |
T6162 |
pobj |
disorder,in |
R4215 |
T6165 |
T6164 |
amod |
common,disorder |
R4216 |
T6166 |
T6164 |
amod |
autosomal,disorder |
R4217 |
T6167 |
T6164 |
amod |
recessive,disorder |
R4218 |
T6168 |
T6169 |
amod |
cystic,fibrosis |
R4219 |
T6169 |
T6164 |
appos |
fibrosis,disorder |
R4220 |
T6170 |
T6161 |
advmod |
alone,implicated |
R4221 |
T6171 |
T6172 |
punct |
[,29 |
R4222 |
T6172 |
T6154 |
parataxis |
29,known |
R4223 |
T6173 |
T6172 |
punct |
],29 |
R4224 |
T6174 |
T6149 |
aux |
can,result |
R4225 |
T6175 |
T6149 |
advmod |
theoretically,result |
R4226 |
T6176 |
T6149 |
prep |
in,result |
R4227 |
T6177 |
T6178 |
punct |
~,"700,000" |
R4228 |
T6178 |
T6179 |
nummod |
"700,000",combinations |
R4229 |
T6179 |
T6176 |
pobj |
combinations,in |
R4230 |
T6180 |
T6179 |
amod |
different,combinations |
R4231 |
T6181 |
T6179 |
amod |
allelic,combinations |
R4232 |
T6182 |
T6145 |
punct |
", ",is |
R4233 |
T6183 |
T6184 |
det |
the,number |
R4234 |
T6184 |
T6145 |
nsubj |
number,is |
R4235 |
T6185 |
T6184 |
amod |
potential,number |
R4236 |
T6186 |
T6184 |
prep |
of,number |
R4237 |
T6187 |
T6188 |
amod |
allelic,combinations |
R4238 |
T6188 |
T6186 |
pobj |
combinations,of |
R4239 |
T6189 |
T6188 |
prep |
of,combinations |
R4240 |
T6190 |
T6191 |
amod |
different,mutations |
R4241 |
T6191 |
T6189 |
pobj |
mutations,of |
R4242 |
T6192 |
T6191 |
amod |
recessive,mutations |
R4243 |
T6193 |
T6191 |
cc |
and,mutations |
R4244 |
T6194 |
T6195 |
amod |
single,polymorphisms |
R4245 |
T6195 |
T6191 |
conj |
polymorphisms,mutations |
R4246 |
T6196 |
T6195 |
compound |
nucleotide,polymorphisms |
R4247 |
T6197 |
T6198 |
npadvmod |
genome,wide |
R4248 |
T6198 |
T6184 |
amod |
wide,number |
R4249 |
T6199 |
T6198 |
punct |
-,wide |
R4250 |
T6200 |
T6145 |
advmod |
currently,is |
R4251 |
T6201 |
T6145 |
acomp |
incalculable,is |
R4252 |
T6202 |
T6145 |
punct |
.,is |
R4253 |
T6204 |
T6205 |
nsubj |
We,suggest |
R4254 |
T6206 |
T6207 |
amod |
biallelic,effects |
R4255 |
T6207 |
T6205 |
dobj |
effects,suggest |
R4256 |
T6208 |
T6205 |
prep |
as,suggest |
R4257 |
T6209 |
T6210 |
det |
a,variable |
R4258 |
T6210 |
T6208 |
pobj |
variable,as |
R4259 |
T6211 |
T6212 |
advmod |
previously,underestimated |
R4260 |
T6212 |
T6213 |
amod |
underestimated,important |
R4261 |
T6213 |
T6210 |
amod |
important,variable |
R4262 |
T6214 |
T6213 |
advmod |
yet,important |
R4263 |
T6215 |
T6205 |
prep |
in,suggest |
R4264 |
T6216 |
T6215 |
pcomp |
considering,in |
R4265 |
T6217 |
T6218 |
compound |
genotype,phenotype |
R4266 |
T6218 |
T6220 |
compound |
phenotype,relationships |
R4267 |
T6219 |
T6218 |
punct |
–,phenotype |
R4268 |
T6220 |
T6216 |
dobj |
relationships,considering |
R4269 |
T6221 |
T6216 |
prep |
from,considering |
R4270 |
T6222 |
T6223 |
amod |
autosomal,disease |
R4271 |
T6223 |
T6221 |
pobj |
disease,from |
R4272 |
T6224 |
T6223 |
amod |
recessive,disease |
R4273 |
T6225 |
T6221 |
prep |
to,from |
R4274 |
T6226 |
T6227 |
amod |
normal,diversity |
R4275 |
T6227 |
T6225 |
pobj |
diversity,to |
R4276 |
T6228 |
T6227 |
amod |
phenotypic,diversity |
R4277 |
T6229 |
T6216 |
prep |
in,considering |
R4278 |
T6230 |
T6229 |
pobj |
mammals,in |
R4279 |
T6231 |
T6205 |
punct |
.,suggest |
R4280 |
T6233 |
T6234 |
nsubj |
Extension,implies |
R4281 |
T6235 |
T6233 |
prep |
of,Extension |
R4282 |
T6236 |
T6237 |
det |
the,concept |
R4283 |
T6237 |
T6235 |
pobj |
concept,of |
R4284 |
T6238 |
T6237 |
amod |
above,concept |
R4285 |
T6239 |
T6240 |
mark |
that,enter |
R4286 |
T6240 |
T6234 |
ccomp |
enter,implies |
R4287 |
T6241 |
T6242 |
amod |
recessive,mutations |
R4288 |
T6242 |
T6240 |
nsubj |
mutations,enter |
R4289 |
T6243 |
T6240 |
aux |
can,enter |
R4290 |
T6244 |
T6245 |
amod |
evolutionary,selection |
R4291 |
T6245 |
T6240 |
dobj |
selection,enter |
R4292 |
T6246 |
T6240 |
prep |
in,enter |
R4293 |
T6247 |
T6246 |
pobj |
F1,in |
R4294 |
T6248 |
T6240 |
prep |
provided,enter |
R4295 |
T6249 |
T6250 |
mark |
that,carries |
R4296 |
T6250 |
T6248 |
pcomp |
carries,provided |
R4297 |
T6251 |
T6252 |
det |
the,allele |
R4298 |
T6252 |
T6250 |
nsubj |
allele,carries |
R4299 |
T6253 |
T6252 |
amod |
second,allele |
R4300 |
T6254 |
T6255 |
det |
a,alteration |
R4301 |
T6255 |
T6250 |
dobj |
alteration,carries |
R4302 |
T6256 |
T6255 |
amod |
different,alteration |
R4303 |
T6257 |
T6255 |
amod |
recessive,alteration |
R4304 |
T6258 |
T6234 |
punct |
.,implies |
R4305 |
T6260 |
T6261 |
advmod |
Finally,highlight |
R4306 |
T6262 |
T6261 |
punct |
", ",highlight |
R4307 |
T6263 |
T6264 |
poss |
our,data |
R4308 |
T6264 |
T6261 |
nsubj |
data,highlight |
R4309 |
T6265 |
T6266 |
det |
the,potential |
R4310 |
T6266 |
T6261 |
dobj |
potential,highlight |
R4311 |
T6267 |
T6266 |
prep |
of,potential |
R4312 |
T6268 |
T6269 |
advmod |
clinically,relevant |
R4313 |
T6269 |
T6270 |
amod |
relevant,alleles |
R4314 |
T6270 |
T6267 |
pobj |
alleles,of |
R4315 |
T6271 |
T6272 |
advmod |
previously,designated |
R4316 |
T6272 |
T6270 |
acl |
designated,alleles |
R4317 |
T6273 |
T6272 |
prep |
as,designated |
R4318 |
T6274 |
T6273 |
amod |
null,as |
R4319 |
T6275 |
T6270 |
punct |
", ",alleles |
R4320 |
T6276 |
T6270 |
prep |
with,alleles |
R4321 |
T6277 |
T6278 |
amod |
little,expression |
R4322 |
T6278 |
T6276 |
pobj |
expression,with |
R4323 |
T6279 |
T6277 |
cc |
or,little |
R4324 |
T6280 |
T6277 |
conj |
no,little |
R4325 |
T6281 |
T6278 |
amod |
detectable,expression |
R4326 |
T6282 |
T6278 |
cc |
or,expression |
R4327 |
T6283 |
T6278 |
conj |
activity,expression |
R4328 |
T6284 |
T6266 |
punct |
", ",potential |
R4329 |
T6285 |
T6286 |
aux |
to,contribute |
R4330 |
T6286 |
T6266 |
acl |
contribute,potential |
R4331 |
T6287 |
T6286 |
advmod |
nonetheless,contribute |
R4332 |
T6288 |
T6286 |
prep |
to,contribute |
R4333 |
T6289 |
T6288 |
pobj |
phenotype,to |
R4334 |
T6290 |
T6261 |
punct |
.,highlight |