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PMC:1584416 / 31581-32355 JSONTXT

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Id Subject Object Predicate Lexical cue
T9280 10-18 NN denotes Genotype
T9281 19-28 NN denotes Phenotype
T9282 18-19 HYPH denotes –
T9283 29-42 NNS denotes Relationships
T9284 43-45 IN denotes in
T9285 46-49 NN denotes XPD
T9286 50-59 NNS denotes Disorders
T9287 59-172 sentence denotes According to the current monoallelic hypothesis, phenotype is determined solely by the causative allele product.
T9288 60-69 VBG denotes According
T9289 122-132 VBN denotes determined
T9290 70-72 IN denotes to
T9291 73-76 DT denotes the
T9292 97-107 NN denotes hypothesis
T9293 77-84 JJ denotes current
T9294 85-96 JJ denotes monoallelic
T9295 107-109 , denotes ,
T9296 109-118 NN denotes phenotype
T9297 119-121 VBZ denotes is
T9298 133-139 RB denotes solely
T9299 140-142 IN denotes by
T9300 143-146 DT denotes the
T9301 164-171 NN denotes product
T9302 147-156 JJ denotes causative
T9303 157-163 NN denotes allele
T9304 171-172 . denotes .
T9305 172-250 sentence denotes If a second, different allele is present, it is considered a functional null.
T9306 173-175 IN denotes If
T9307 203-205 VBZ denotes is
T9308 176-177 DT denotes a
T9309 196-202 NN denotes allele
T9310 178-184 JJ denotes second
T9311 184-186 , denotes ,
T9312 186-195 JJ denotes different
T9313 221-231 VBN denotes considered
T9314 206-213 JJ denotes present
T9315 213-215 , denotes ,
T9316 215-217 PRP denotes it
T9317 218-220 VBZ denotes is
T9318 232-233 DT denotes a
T9319 245-249 NN denotes null
T9320 234-244 JJ denotes functional
T9321 249-250 . denotes .
T9322 250-350 sentence denotes There is a lack of any correlation between the site of the XPD mutation and the resulting disorder.
T9323 251-256 EX denotes There
T9324 257-259 VBZ denotes is
T9325 260-261 DT denotes a
T9326 262-266 NN denotes lack
T9327 267-269 IN denotes of
T9328 270-273 DT denotes any
T9329 274-285 NN denotes correlation
T9330 286-293 IN denotes between
T9331 294-297 DT denotes the
T9332 298-302 NN denotes site
T9333 303-305 IN denotes of
T9334 306-309 DT denotes the
T9335 314-322 NN denotes mutation
T9336 310-313 NN denotes XPD
T9337 323-326 CC denotes and
T9338 327-330 DT denotes the
T9339 341-349 NN denotes disorder
T9340 331-340 VBG denotes resulting
T9341 349-350 . denotes .
T9342 350-466 sentence denotes We propose a biallelic hypothesis for compound heterozygotes in which both alleles can contribute to the phenotype.
T9343 351-353 PRP denotes We
T9344 354-361 VBP denotes propose
T9345 362-363 DT denotes a
T9346 374-384 NN denotes hypothesis
T9347 364-373 JJ denotes biallelic
T9348 385-388 IN denotes for
T9349 389-397 NN denotes compound
T9350 398-411 NNS denotes heterozygotes
T9351 412-414 IN denotes in
T9352 438-448 VB denotes contribute
T9353 415-420 WDT denotes which
T9354 421-425 DT denotes both
T9355 426-433 NNS denotes alleles
T9356 434-437 MD denotes can
T9357 449-451 IN denotes to
T9358 452-455 DT denotes the
T9359 456-465 NN denotes phenotype
T9360 465-466 . denotes .
T9361 466-703 sentence denotes Examples of compound heterozygous patients in which a second, presumed null allele is likely to contribute to disease outcome are provided above in comparison to corresponding homo- or hemizygous patients with the same causative allele.
T9362 467-475 NNS denotes Examples
T9363 597-605 VBN denotes provided
T9364 476-478 IN denotes of
T9365 479-487 NN denotes compound
T9366 501-509 NNS denotes patients
T9367 488-500 JJ denotes heterozygous
T9368 510-512 IN denotes in
T9369 550-552 VBZ denotes is
T9370 513-518 WDT denotes which
T9371 519-520 DT denotes a
T9372 543-549 NN denotes allele
T9373 521-527 JJ denotes second
T9374 527-529 , denotes ,
T9375 529-537 JJ denotes presumed
T9376 538-542 JJ denotes null
T9377 553-559 JJ denotes likely
T9378 560-562 TO denotes to
T9379 563-573 VB denotes contribute
T9380 574-576 IN denotes to
T9381 577-584 NN denotes disease
T9382 585-592 NN denotes outcome
T9383 593-596 VBP denotes are
T9384 606-611 RB denotes above
T9385 612-614 IN denotes in
T9386 615-625 NN denotes comparison
T9387 626-628 IN denotes to
T9388 629-642 VBG denotes corresponding
T9389 663-671 NNS denotes patients
T9390 643-647 AFX denotes homo
T9391 652-662 JJ denotes hemizygous
T9392 647-648 HYPH denotes -
T9393 649-651 CC denotes or
T9394 672-676 IN denotes with
T9395 677-680 DT denotes the
T9396 696-702 NN denotes allele
T9397 681-685 JJ denotes same
T9398 686-695 JJ denotes causative
T9399 702-703 . denotes .
T9400 703-774 sentence denotes Numbers in the schematic of the protein indicate the helicase domains.
T9401 704-711 NNS denotes Numbers
T9402 744-752 VBP denotes indicate
T9403 712-714 IN denotes in
T9404 715-718 DT denotes the
T9405 719-728 NN denotes schematic
T9406 729-731 IN denotes of
T9407 732-735 DT denotes the
T9408 736-743 NN denotes protein
T9409 753-756 DT denotes the
T9410 766-773 NNS denotes domains
T9411 757-765 NN denotes helicase
T9412 773-774 . denotes .
R6329 T9280 T9281 compound Genotype,Phenotype
R6330 T9281 T9283 compound Phenotype,Relationships
R6331 T9282 T9281 punct –,Phenotype
R6332 T9284 T9283 prep in,Relationships
R6333 T9285 T9286 compound XPD,Disorders
R6334 T9286 T9284 pobj Disorders,in
R6335 T9288 T9289 prep According,determined
R6336 T9290 T9288 prep to,According
R6337 T9291 T9292 det the,hypothesis
R6338 T9292 T9290 pobj hypothesis,to
R6339 T9293 T9292 amod current,hypothesis
R6340 T9294 T9292 amod monoallelic,hypothesis
R6341 T9295 T9289 punct ", ",determined
R6342 T9296 T9289 nsubjpass phenotype,determined
R6343 T9297 T9289 auxpass is,determined
R6344 T9298 T9299 advmod solely,by
R6345 T9299 T9289 agent by,determined
R6346 T9300 T9301 det the,product
R6347 T9301 T9299 pobj product,by
R6348 T9302 T9301 amod causative,product
R6349 T9303 T9301 compound allele,product
R6350 T9304 T9289 punct .,determined
R6351 T9306 T9307 mark If,is
R6352 T9307 T9313 advcl is,considered
R6353 T9308 T9309 det a,allele
R6354 T9309 T9307 nsubj allele,is
R6355 T9310 T9309 amod second,allele
R6356 T9311 T9309 punct ", ",allele
R6357 T9312 T9309 amod different,allele
R6358 T9314 T9307 acomp present,is
R6359 T9315 T9313 punct ", ",considered
R6360 T9316 T9313 nsubjpass it,considered
R6361 T9317 T9313 auxpass is,considered
R6362 T9318 T9319 det a,null
R6363 T9319 T9313 oprd null,considered
R6364 T9320 T9319 amod functional,null
R6365 T9321 T9313 punct .,considered
R6366 T9323 T9324 expl There,is
R6367 T9325 T9326 det a,lack
R6368 T9326 T9324 attr lack,is
R6369 T9327 T9326 prep of,lack
R6370 T9328 T9329 det any,correlation
R6371 T9329 T9327 pobj correlation,of
R6372 T9330 T9329 prep between,correlation
R6373 T9331 T9332 det the,site
R6374 T9332 T9330 pobj site,between
R6375 T9333 T9332 prep of,site
R6376 T9334 T9335 det the,mutation
R6377 T9335 T9333 pobj mutation,of
R6378 T9336 T9335 compound XPD,mutation
R6379 T9337 T9332 cc and,site
R6380 T9338 T9339 det the,disorder
R6381 T9339 T9332 conj disorder,site
R6382 T9340 T9339 amod resulting,disorder
R6383 T9341 T9324 punct .,is
R6384 T9343 T9344 nsubj We,propose
R6385 T9345 T9346 det a,hypothesis
R6386 T9346 T9344 dobj hypothesis,propose
R6387 T9347 T9346 amod biallelic,hypothesis
R6388 T9348 T9346 prep for,hypothesis
R6389 T9349 T9350 compound compound,heterozygotes
R6390 T9350 T9348 pobj heterozygotes,for
R6391 T9351 T9352 prep in,contribute
R6392 T9352 T9346 relcl contribute,hypothesis
R6393 T9353 T9351 pobj which,in
R6394 T9354 T9355 det both,alleles
R6395 T9355 T9352 nsubj alleles,contribute
R6396 T9356 T9352 aux can,contribute
R6397 T9357 T9352 prep to,contribute
R6398 T9358 T9359 det the,phenotype
R6399 T9359 T9357 pobj phenotype,to
R6400 T9360 T9344 punct .,propose
R6401 T9362 T9363 nsubjpass Examples,provided
R6402 T9364 T9362 prep of,Examples
R6403 T9365 T9366 nmod compound,patients
R6404 T9366 T9364 pobj patients,of
R6405 T9367 T9366 amod heterozygous,patients
R6406 T9368 T9369 prep in,is
R6407 T9369 T9366 relcl is,patients
R6408 T9370 T9368 pobj which,in
R6409 T9371 T9372 det a,allele
R6410 T9372 T9369 nsubj allele,is
R6411 T9373 T9372 amod second,allele
R6412 T9374 T9372 punct ", ",allele
R6413 T9375 T9376 amod presumed,null
R6414 T9376 T9372 amod null,allele
R6415 T9377 T9369 acomp likely,is
R6416 T9378 T9379 aux to,contribute
R6417 T9379 T9377 xcomp contribute,likely
R6418 T9380 T9379 prep to,contribute
R6419 T9381 T9382 compound disease,outcome
R6420 T9382 T9380 pobj outcome,to
R6421 T9383 T9363 auxpass are,provided
R6422 T9384 T9363 advmod above,provided
R6423 T9385 T9363 prep in,provided
R6424 T9386 T9385 pobj comparison,in
R6425 T9387 T9386 prep to,comparison
R6426 T9388 T9389 amod corresponding,patients
R6427 T9389 T9387 pobj patients,to
R6428 T9390 T9391 advmod homo,hemizygous
R6429 T9391 T9389 amod hemizygous,patients
R6430 T9392 T9391 punct -,hemizygous
R6431 T9393 T9391 cc or,hemizygous
R6432 T9394 T9389 prep with,patients
R6433 T9395 T9396 det the,allele
R6434 T9396 T9394 pobj allele,with
R6435 T9397 T9396 amod same,allele
R6436 T9398 T9396 amod causative,allele
R6437 T9399 T9363 punct .,provided
R6438 T9401 T9402 nsubj Numbers,indicate
R6439 T9403 T9401 prep in,Numbers
R6440 T9404 T9405 det the,schematic
R6441 T9405 T9403 pobj schematic,in
R6442 T9406 T9405 prep of,schematic
R6443 T9407 T9408 det the,protein
R6444 T9408 T9406 pobj protein,of
R6445 T9409 T9410 det the,domains
R6446 T9410 T9402 dobj domains,indicate
R6447 T9411 T9410 compound helicase,domains
R6448 T9412 T9402 punct .,indicate

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9254 46-49 PR:000007164 denotes XPD
T9255 89-96 SO:0001023 denotes allelic
T9256 157-163 SO:0001023 denotes allele
T9257 196-202 SO:0001023 denotes allele
T9258 310-313 PR:000007164 denotes XPD
T9259 366-373 SO:0001023 denotes allelic
T9260 426-433 SO:0001023 denotes alleles
T9261 543-549 SO:0001023 denotes allele
T9262 696-702 SO:0001023 denotes allele
T9263 766-773 SO:0000417 denotes domains

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T9264 10-18 SO_EXT:genotype_or_entity_with_genotype denotes Genotype
T9265 46-49 PR_EXT:000007164 denotes XPD
T9266 89-96 SO_EXT:0001023 denotes allelic
T9267 157-163 SO_EXT:0001023 denotes allele
T9268 196-202 SO_EXT:0001023 denotes allele
T9269 245-249 SO_EXT:null_sequence_entity denotes null
T9270 310-313 PR_EXT:000007164 denotes XPD
T9271 314-322 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9272 366-373 SO_EXT:0001023 denotes allelic
T9273 426-433 SO_EXT:0001023 denotes alleles
T9274 538-542 SO_EXT:sequence_nullness denotes null
T9275 543-549 SO_EXT:0001023 denotes allele
T9276 696-702 SO_EXT:0001023 denotes allele
T9277 736-743 CHEBI_PR_EXT:protein denotes protein
T9278 757-765 GO_EXT:0004386 denotes helicase
T9279 766-773 SO_EXT:0000417 denotes domains