PMC:1584416 / 27946-28408 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/1584416","sourcedb":"PMC","sourceid":"1584416","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1584416","text":"In its role in the repair of UV photolesions, the Xpd†XPCS allele imparted a clear UV survival benefit over a single XpdTTD allele or two XpdXPCS alleles independent of expression levels, which is consistent with interallelic complementation. However, the observation that no other cellular or biochemical UV-related parameters were improved in XpdTTD/ †XPCS argues against complementation of this repair activity in the rescue of TTD progeroid symptoms in vivo.","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T5131","span":{"begin":0,"end":2},"obj":"IN"},{"id":"T5132","span":{"begin":66,"end":74},"obj":"VBD"},{"id":"T5133","span":{"begin":3,"end":6},"obj":"PRP$"},{"id":"T5134","span":{"begin":7,"end":11},"obj":"NN"},{"id":"T5135","span":{"begin":12,"end":14},"obj":"IN"},{"id":"T5136","span":{"begin":15,"end":18},"obj":"DT"},{"id":"T5137","span":{"begin":19,"end":25},"obj":"NN"},{"id":"T5138","span":{"begin":26,"end":28},"obj":"IN"},{"id":"T5139","span":{"begin":29,"end":31},"obj":"NN"},{"id":"T5140","span":{"begin":32,"end":44},"obj":"NNS"},{"id":"T5141","span":{"begin":44,"end":46},"obj":","},{"id":"T5142","span":{"begin":46,"end":49},"obj":"DT"},{"id":"T5143","span":{"begin":59,"end":65},"obj":"NN"},{"id":"T5144","span":{"begin":50,"end":58},"obj":"NN"},{"id":"T5145","span":{"begin":75,"end":76},"obj":"DT"},{"id":"T5146","span":{"begin":95,"end":102},"obj":"NN"},{"id":"T5147","span":{"begin":77,"end":82},"obj":"JJ"},{"id":"T5148","span":{"begin":83,"end":85},"obj":"NN"},{"id":"T5149","span":{"begin":86,"end":94},"obj":"NN"},{"id":"T5150","span":{"begin":103,"end":107},"obj":"IN"},{"id":"T5151","span":{"begin":108,"end":109},"obj":"DT"},{"id":"T5152","span":{"begin":124,"end":130},"obj":"NN"},{"id":"T5153","span":{"begin":110,"end":116},"obj":"JJ"},{"id":"T5154","span":{"begin":117,"end":123},"obj":"NN"},{"id":"T5155","span":{"begin":131,"end":133},"obj":"CC"},{"id":"T5156","span":{"begin":134,"end":137},"obj":"CD"},{"id":"T5157","span":{"begin":146,"end":153},"obj":"NNS"},{"id":"T5158","span":{"begin":138,"end":145},"obj":"NN"},{"id":"T5159","span":{"begin":154,"end":165},"obj":"JJ"},{"id":"T5160","span":{"begin":166,"end":168},"obj":"IN"},{"id":"T5161","span":{"begin":169,"end":179},"obj":"NN"},{"id":"T5162","span":{"begin":180,"end":186},"obj":"NNS"},{"id":"T5163","span":{"begin":186,"end":188},"obj":","},{"id":"T5164","span":{"begin":188,"end":193},"obj":"WDT"},{"id":"T5165","span":{"begin":194,"end":196},"obj":"VBZ"},{"id":"T5166","span":{"begin":197,"end":207},"obj":"JJ"},{"id":"T5167","span":{"begin":208,"end":212},"obj":"IN"},{"id":"T5168","span":{"begin":213,"end":225},"obj":"JJ"},{"id":"T5169","span":{"begin":226,"end":241},"obj":"NN"},{"id":"T5170","span":{"begin":241,"end":242},"obj":"."},{"id":"T5171","span":{"begin":242,"end":462},"obj":"sentence"},{"id":"T5172","span":{"begin":243,"end":250},"obj":"RB"},{"id":"T5173","span":{"begin":359,"end":365},"obj":"VBZ"},{"id":"T5174","span":{"begin":250,"end":252},"obj":","},{"id":"T5175","span":{"begin":252,"end":255},"obj":"DT"},{"id":"T5176","span":{"begin":256,"end":267},"obj":"NN"},{"id":"T5177","span":{"begin":268,"end":272},"obj":"IN"},{"id":"T5178","span":{"begin":333,"end":341},"obj":"VBN"},{"id":"T5179","span":{"begin":273,"end":275},"obj":"DT"},{"id":"T5180","span":{"begin":317,"end":327},"obj":"NNS"},{"id":"T5181","span":{"begin":276,"end":281},"obj":"JJ"},{"id":"T5182","span":{"begin":282,"end":290},"obj":"JJ"},{"id":"T5183","span":{"begin":291,"end":293},"obj":"CC"},{"id":"T5184","span":{"begin":294,"end":305},"obj":"JJ"},{"id":"T5185","span":{"begin":306,"end":308},"obj":"NN"},{"id":"T5186","span":{"begin":309,"end":316},"obj":"VBN"},{"id":"T5187","span":{"begin":308,"end":309},"obj":"HYPH"},{"id":"T5188","span":{"begin":328,"end":332},"obj":"VBD"},{"id":"T5189","span":{"begin":342,"end":344},"obj":"IN"},{"id":"T5190","span":{"begin":345,"end":351},"obj":"NN"},{"id":"T5191","span":{"begin":352,"end":358},"obj":"NN"},{"id":"T5192","span":{"begin":351,"end":352},"obj":"HYPH"},{"id":"T5193","span":{"begin":366,"end":373},"obj":"IN"},{"id":"T5194","span":{"begin":374,"end":389},"obj":"NN"},{"id":"T5195","span":{"begin":390,"end":392},"obj":"IN"},{"id":"T5196","span":{"begin":393,"end":397},"obj":"DT"},{"id":"T5197","span":{"begin":405,"end":413},"obj":"NN"},{"id":"T5198","span":{"begin":398,"end":404},"obj":"NN"},{"id":"T5199","span":{"begin":414,"end":416},"obj":"IN"},{"id":"T5200","span":{"begin":417,"end":420},"obj":"DT"},{"id":"T5201","span":{"begin":421,"end":427},"obj":"NN"},{"id":"T5202","span":{"begin":428,"end":430},"obj":"IN"},{"id":"T5203","span":{"begin":431,"end":434},"obj":"NN"},{"id":"T5204","span":{"begin":445,"end":453},"obj":"NNS"},{"id":"T5205","span":{"begin":435,"end":444},"obj":"JJ"},{"id":"T5206","span":{"begin":454,"end":456},"obj":"FW"},{"id":"T5207","span":{"begin":457,"end":461},"obj":"FW"},{"id":"T5208","span":{"begin":461,"end":462},"obj":"."}],"relations":[{"id":"R3488","pred":"prep","subj":"T5131","obj":"T5132"},{"id":"R3489","pred":"poss","subj":"T5133","obj":"T5134"},{"id":"R3490","pred":"pobj","subj":"T5134","obj":"T5131"},{"id":"R3491","pred":"prep","subj":"T5135","obj":"T5134"},{"id":"R3492","pred":"det","subj":"T5136","obj":"T5137"},{"id":"R3493","pred":"pobj","subj":"T5137","obj":"T5135"},{"id":"R3494","pred":"prep","subj":"T5138","obj":"T5137"},{"id":"R3495","pred":"compound","subj":"T5139","obj":"T5140"},{"id":"R3496","pred":"pobj","subj":"T5140","obj":"T5138"},{"id":"R3497","pred":"punct","subj":"T5141","obj":"T5132"},{"id":"R3498","pred":"det","subj":"T5142","obj":"T5143"},{"id":"R3499","pred":"nsubj","subj":"T5143","obj":"T5132"},{"id":"R3500","pred":"compound","subj":"T5144","obj":"T5143"},{"id":"R3501","pred":"det","subj":"T5145","obj":"T5146"},{"id":"R3502","pred":"dobj","subj":"T5146","obj":"T5132"},{"id":"R3503","pred":"amod","subj":"T5147","obj":"T5146"},{"id":"R3504","pred":"compound","subj":"T5148","obj":"T5146"},{"id":"R3505","pred":"compound","subj":"T5149","obj":"T5146"},{"id":"R3506","pred":"prep","subj":"T5150","obj":"T5146"},{"id":"R3507","pred":"det","subj":"T5151","obj":"T5152"},{"id":"R3508","pred":"pobj","subj":"T5152","obj":"T5150"},{"id":"R3509","pred":"amod","subj":"T5153","obj":"T5152"},{"id":"R3510","pred":"compound","subj":"T5154","obj":"T5152"},{"id":"R3511","pred":"cc","subj":"T5155","obj":"T5152"},{"id":"R3512","pred":"nummod","subj":"T5156","obj":"T5157"},{"id":"R3513","pred":"conj","subj":"T5157","obj":"T5152"},{"id":"R3514","pred":"compound","subj":"T5158","obj":"T5157"},{"id":"R3515","pred":"amod","subj":"T5159","obj":"T5146"},{"id":"R3516","pred":"prep","subj":"T5160","obj":"T5159"},{"id":"R3517","pred":"compound","subj":"T5161","obj":"T5162"},{"id":"R3518","pred":"pobj","subj":"T5162","obj":"T5160"},{"id":"R3519","pred":"punct","subj":"T5163","obj":"T5132"},{"id":"R3520","pred":"dep","subj":"T5164","obj":"T5165"},{"id":"R3521","pred":"advcl","subj":"T5165","obj":"T5132"},{"id":"R3522","pred":"acomp","subj":"T5166","obj":"T5165"},{"id":"R3523","pred":"prep","subj":"T5167","obj":"T5166"},{"id":"R3524","pred":"amod","subj":"T5168","obj":"T5169"},{"id":"R3525","pred":"pobj","subj":"T5169","obj":"T5167"},{"id":"R3526","pred":"punct","subj":"T5170","obj":"T5132"},{"id":"R3527","pred":"advmod","subj":"T5172","obj":"T5173"},{"id":"R3528","pred":"punct","subj":"T5174","obj":"T5173"},{"id":"R3529","pred":"det","subj":"T5175","obj":"T5176"},{"id":"R3530","pred":"nsubj","subj":"T5176","obj":"T5173"},{"id":"R3531","pred":"mark","subj":"T5177","obj":"T5178"},{"id":"R3532","pred":"acl","subj":"T5178","obj":"T5176"},{"id":"R3533","pred":"det","subj":"T5179","obj":"T5180"},{"id":"R3534","pred":"nsubjpass","subj":"T5180","obj":"T5178"},{"id":"R3535","pred":"amod","subj":"T5181","obj":"T5180"},{"id":"R3536","pred":"amod","subj":"T5182","obj":"T5180"},{"id":"R3537","pred":"cc","subj":"T5183","obj":"T5182"},{"id":"R3538","pred":"conj","subj":"T5184","obj":"T5182"},{"id":"R3539","pred":"npadvmod","subj":"T5185","obj":"T5186"},{"id":"R3540","pred":"amod","subj":"T5186","obj":"T5180"},{"id":"R3541","pred":"punct","subj":"T5187","obj":"T5186"},{"id":"R3542","pred":"auxpass","subj":"T5188","obj":"T5178"},{"id":"R3543","pred":"prep","subj":"T5189","obj":"T5178"},{"id":"R3544","pred":"compound","subj":"T5190","obj":"T5191"},{"id":"R3545","pred":"pobj","subj":"T5191","obj":"T5189"},{"id":"R3546","pred":"punct","subj":"T5192","obj":"T5191"},{"id":"R3547","pred":"prep","subj":"T5193","obj":"T5173"},{"id":"R3548","pred":"pobj","subj":"T5194","obj":"T5193"},{"id":"R3549","pred":"prep","subj":"T5195","obj":"T5194"},{"id":"R3550","pred":"det","subj":"T5196","obj":"T5197"},{"id":"R3551","pred":"pobj","subj":"T5197","obj":"T5195"},{"id":"R3552","pred":"compound","subj":"T5198","obj":"T5197"},{"id":"R3553","pred":"prep","subj":"T5199","obj":"T5194"},{"id":"R3554","pred":"det","subj":"T5200","obj":"T5201"},{"id":"R3555","pred":"pobj","subj":"T5201","obj":"T5199"},{"id":"R3556","pred":"prep","subj":"T5202","obj":"T5201"},{"id":"R3557","pred":"nmod","subj":"T5203","obj":"T5204"},{"id":"R3558","pred":"pobj","subj":"T5204","obj":"T5202"},{"id":"R3559","pred":"amod","subj":"T5205","obj":"T5204"},{"id":"R3560","pred":"advmod","subj":"T5206","obj":"T5207"},{"id":"R3561","pred":"advmod","subj":"T5207","obj":"T5201"},{"id":"R3562","pred":"punct","subj":"T5208","obj":"T5173"}],"attributes":[{"subj":"T5131","pred":"source","obj":"craft-sa-dev"},{"subj":"T5132","pred":"source","obj":"craft-sa-dev"},{"subj":"T5133","pred":"source","obj":"craft-sa-dev"},{"subj":"T5134","pred":"source","obj":"craft-sa-dev"},{"subj":"T5135","pred":"source","obj":"craft-sa-dev"},{"subj":"T5136","pred":"source","obj":"craft-sa-dev"},{"subj":"T5137","pred":"source","obj":"craft-sa-dev"},{"subj":"T5138","pred":"source","obj":"craft-sa-dev"},{"subj":"T5139","pred":"source","obj":"craft-sa-dev"},{"subj":"T5140","pred":"source","obj":"craft-sa-dev"},{"subj":"T5141","pred":"source","obj":"craft-sa-dev"},{"subj":"T5142","pred":"source","obj":"craft-sa-dev"},{"subj":"T5143","pred":"source","obj":"craft-sa-dev"},{"subj":"T5144","pred":"source","obj":"craft-sa-dev"},{"subj":"T5145","pred":"source","obj":"craft-sa-dev"},{"subj":"T5146","pred":"source","obj":"craft-sa-dev"},{"subj":"T5147","pred":"source","obj":"craft-sa-dev"},{"subj":"T5148","pred":"source","obj":"craft-sa-dev"},{"subj":"T5149","pred":"source","obj":"craft-sa-dev"},{"subj":"T5150","pred":"source","obj":"craft-sa-dev"},{"subj":"T5151","pred":"source","obj":"craft-sa-dev"},{"subj":"T5152","pred":"source","obj":"craft-sa-dev"},{"subj":"T5153","pred":"source","obj":"craft-sa-dev"},{"subj":"T5154","pred":"source","obj":"craft-sa-dev"},{"subj":"T5155","pred":"source","obj":"craft-sa-dev"},{"subj":"T5156","pred":"source","obj":"craft-sa-dev"},{"subj":"T5157","pred":"source","obj":"craft-sa-dev"},{"subj":"T5158","pred":"source","obj":"craft-sa-dev"},{"subj":"T5159","pred":"source","obj":"craft-sa-dev"},{"subj":"T5160","pred":"source","obj":"craft-sa-dev"},{"subj":"T5161","pred":"source","obj":"craft-sa-dev"},{"subj":"T5162","pred":"source","obj":"craft-sa-dev"},{"subj":"T5163","pred":"source","obj":"craft-sa-dev"},{"subj":"T5164","pred":"source","obj":"craft-sa-dev"},{"subj":"T5165","pred":"source","obj":"craft-sa-dev"},{"subj":"T5166","pred":"source","obj":"craft-sa-dev"},{"subj":"T5167","pred":"source","obj":"craft-sa-dev"},{"subj":"T5168","pred":"source","obj":"craft-sa-dev"},{"subj":"T5169","pred":"source","obj":"craft-sa-dev"},{"subj":"T5170","pred":"source","obj":"craft-sa-dev"},{"subj":"T5171","pred":"source","obj":"craft-sa-dev"},{"subj":"T5172","pred":"source","obj":"craft-sa-dev"},{"subj":"T5173","pred":"source","obj":"craft-sa-dev"},{"subj":"T5174","pred":"source","obj":"craft-sa-dev"},{"subj":"T5175","pred":"source","obj":"craft-sa-dev"},{"subj":"T5176","pred":"source","obj":"craft-sa-dev"},{"subj":"T5177","pred":"source","obj":"craft-sa-dev"},{"subj":"T5178","pred":"source","obj":"craft-sa-dev"},{"subj":"T5179","pred":"source","obj":"craft-sa-dev"},{"subj":"T5180","pred":"source","obj":"craft-sa-dev"},{"subj":"T5181","pred":"source","obj":"craft-sa-dev"},{"subj":"T5182","pred":"source","obj":"craft-sa-dev"},{"subj":"T5183","pred":"source","obj":"craft-sa-dev"},{"subj":"T5184","pred":"source","obj":"craft-sa-dev"},{"subj":"T5185","pred":"source","obj":"craft-sa-dev"},{"subj":"T5186","pred":"source","obj":"craft-sa-dev"},{"subj":"T5187","pred":"source","obj":"craft-sa-dev"},{"subj":"T5188","pred":"source","obj":"craft-sa-dev"},{"subj":"T5189","pred":"source","obj":"craft-sa-dev"},{"subj":"T5190","pred":"source","obj":"craft-sa-dev"},{"subj":"T5191","pred":"source","obj":"craft-sa-dev"},{"subj":"T5192","pred":"source","obj":"craft-sa-dev"},{"subj":"T5193","pred":"source","obj":"craft-sa-dev"},{"subj":"T5194","pred":"source","obj":"craft-sa-dev"},{"subj":"T5195","pred":"source","obj":"craft-sa-dev"},{"subj":"T5196","pred":"source","obj":"craft-sa-dev"},{"subj":"T5197","pred":"source","obj":"craft-sa-dev"},{"subj":"T5198","pred":"source","obj":"craft-sa-dev"},{"subj":"T5199","pred":"source","obj":"craft-sa-dev"},{"subj":"T5200","pred":"source","obj":"craft-sa-dev"},{"subj":"T5201","pred":"source","obj":"craft-sa-dev"},{"subj":"T5202","pred":"source","obj":"craft-sa-dev"},{"subj":"T5203","pred":"source","obj":"craft-sa-dev"},{"subj":"T5204","pred":"source","obj":"craft-sa-dev"},{"subj":"T5205","pred":"source","obj":"craft-sa-dev"},{"subj":"T5206","pred":"source","obj":"craft-sa-dev"},{"subj":"T5207","pred":"source","obj":"craft-sa-dev"},{"subj":"T5208","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T4685","span":{"begin":19,"end":25},"obj":"GO:0006281"},{"id":"T4686","span":{"begin":50,"end":53},"obj":"PR:000007164"},{"id":"T4687","span":{"begin":59,"end":65},"obj":"SO:0001023"},{"id":"T4688","span":{"begin":117,"end":120},"obj":"PR:000007164"},{"id":"T4689","span":{"begin":124,"end":130},"obj":"SO:0001023"},{"id":"T4690","span":{"begin":138,"end":141},"obj":"PR:000007164"},{"id":"T4691","span":{"begin":146,"end":153},"obj":"SO:0001023"},{"id":"T4692","span":{"begin":169,"end":179},"obj":"GO:0010467"},{"id":"T4693","span":{"begin":218,"end":225},"obj":"SO:0001023"},{"id":"T4694","span":{"begin":345,"end":348},"obj":"PR:000007164"},{"id":"T4695","span":{"begin":398,"end":404},"obj":"GO:0006281"}],"attributes":[{"subj":"T4685","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4686","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4687","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4688","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4689","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4690","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4691","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4692","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4693","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4694","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T4695","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T4791","span":{"begin":19,"end":25},"obj":"GO:0006281"},{"id":"T4792","span":{"begin":50,"end":53},"obj":"PR_EXT:000007164"},{"id":"T4793","span":{"begin":59,"end":65},"obj":"SO_EXT:0001023"},{"id":"T4794","span":{"begin":117,"end":120},"obj":"PR_EXT:000007164"},{"id":"T4795","span":{"begin":124,"end":130},"obj":"SO_EXT:0001023"},{"id":"T4796","span":{"begin":138,"end":141},"obj":"PR_EXT:000007164"},{"id":"T4797","span":{"begin":146,"end":153},"obj":"SO_EXT:0001023"},{"id":"T4798","span":{"begin":169,"end":179},"obj":"GO:0010467"},{"id":"T4799","span":{"begin":218,"end":225},"obj":"SO_EXT:0001023"},{"id":"T4800","span":{"begin":282,"end":290},"obj":"CL_GO_EXT:cell"},{"id":"T4801","span":{"begin":294,"end":305},"obj":"CHEBI_EXT:biochemical"},{"id":"T4802","span":{"begin":345,"end":348},"obj":"PR_EXT:000007164"},{"id":"T4803","span":{"begin":398,"end":404},"obj":"GO:0006281"},{"id":"T4804","span":{"begin":421,"end":427},"obj":"SO_EXT:sequence_rescue_process"}],"attributes":[{"subj":"T4791","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4792","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4793","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4794","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4795","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4796","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4797","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4798","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4799","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4800","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4801","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4802","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4803","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T4804","pred":"source","obj":"craft-ca-core-ex-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#abec93","default":true},{"id":"craft-ca-core-dev","color":"#ec93c5"},{"id":"craft-ca-core-ex-dev","color":"#93dfec"}]}]}}