Id |
Subject |
Object |
Predicate |
Lexical cue |
T4805 |
0-5 |
NN |
denotes |
TFIIH |
T4806 |
6-8 |
IN |
denotes |
in |
T4807 |
9-22 |
NN |
denotes |
Transcription |
T4808 |
23-26 |
CC |
denotes |
and |
T4809 |
27-33 |
NN |
denotes |
Repair |
T4810 |
33-35 |
: |
denotes |
: |
T4811 |
35-45 |
NNS |
denotes |
Mechanisms |
T4812 |
46-48 |
IN |
denotes |
of |
T4813 |
49-52 |
NN |
denotes |
XPD |
T4814 |
61-71 |
NN |
denotes |
Pleiotropy |
T4815 |
53-60 |
NN |
denotes |
Disease |
T4816 |
71-361 |
sentence |
denotes |
We observed differences in the ability of XpdTTD versus homozygous lethal Xpd†XPCS and Xpd†XP alleles to function in two transcription-related phenotypes separated in the organism by both time and space: embryonic lethality and terminal differentiation of enucleating skin and blood cells. |
T4817 |
72-74 |
PRP |
denotes |
We |
T4818 |
75-83 |
VBD |
denotes |
observed |
T4819 |
84-95 |
NNS |
denotes |
differences |
T4820 |
96-98 |
IN |
denotes |
in |
T4821 |
99-102 |
DT |
denotes |
the |
T4822 |
103-110 |
NN |
denotes |
ability |
T4823 |
111-113 |
IN |
denotes |
of |
T4824 |
114-120 |
NN |
denotes |
XpdTTD |
T4825 |
121-127 |
CC |
denotes |
versus |
T4826 |
128-138 |
JJ |
denotes |
homozygous |
T4827 |
166-173 |
NNS |
denotes |
alleles |
T4828 |
139-145 |
JJ |
denotes |
lethal |
T4829 |
146-154 |
NN |
denotes |
Xpd†XPCS |
T4830 |
155-158 |
CC |
denotes |
and |
T4831 |
159-165 |
NN |
denotes |
Xpd†XP |
T4832 |
174-176 |
TO |
denotes |
to |
T4833 |
177-185 |
VB |
denotes |
function |
T4834 |
186-188 |
IN |
denotes |
in |
T4835 |
189-192 |
CD |
denotes |
two |
T4836 |
215-225 |
NNS |
denotes |
phenotypes |
T4837 |
193-206 |
NN |
denotes |
transcription |
T4838 |
207-214 |
VBN |
denotes |
related |
T4839 |
206-207 |
HYPH |
denotes |
- |
T4840 |
226-235 |
VBN |
denotes |
separated |
T4841 |
236-238 |
IN |
denotes |
in |
T4842 |
239-242 |
DT |
denotes |
the |
T4843 |
243-251 |
NN |
denotes |
organism |
T4844 |
252-254 |
IN |
denotes |
by |
T4845 |
255-259 |
CC |
denotes |
both |
T4846 |
260-264 |
NN |
denotes |
time |
T4847 |
265-268 |
CC |
denotes |
and |
T4848 |
269-274 |
NN |
denotes |
space |
T4849 |
274-276 |
: |
denotes |
: |
T4850 |
276-285 |
JJ |
denotes |
embryonic |
T4851 |
286-295 |
NN |
denotes |
lethality |
T4852 |
296-299 |
CC |
denotes |
and |
T4853 |
300-308 |
JJ |
denotes |
terminal |
T4854 |
309-324 |
NN |
denotes |
differentiation |
T4855 |
325-327 |
IN |
denotes |
of |
T4856 |
328-339 |
VBG |
denotes |
enucleating |
T4857 |
340-344 |
NN |
denotes |
skin |
T4858 |
345-348 |
CC |
denotes |
and |
T4859 |
349-354 |
NN |
denotes |
blood |
T4860 |
355-360 |
NNS |
denotes |
cells |
T4861 |
360-361 |
. |
denotes |
. |
T4862 |
361-541 |
sentence |
denotes |
The preblastocyst-stage homozygous lethality shared by the XpdKO, Xpd†XPCS, and Xpd†XP alleles most likely reflects a defect in basal transcription that is incompatible with life. |
T4863 |
362-365 |
DT |
denotes |
The |
T4864 |
397-406 |
NN |
denotes |
lethality |
T4865 |
366-379 |
NN |
denotes |
preblastocyst |
T4866 |
380-385 |
NN |
denotes |
stage |
T4867 |
379-380 |
HYPH |
denotes |
- |
T4868 |
386-396 |
JJ |
denotes |
homozygous |
T4869 |
469-477 |
VBZ |
denotes |
reflects |
T4870 |
407-413 |
VBN |
denotes |
shared |
T4871 |
414-416 |
IN |
denotes |
by |
T4872 |
417-420 |
DT |
denotes |
the |
T4873 |
449-456 |
NNS |
denotes |
alleles |
T4874 |
421-426 |
NN |
denotes |
XpdKO |
T4875 |
426-428 |
, |
denotes |
, |
T4876 |
428-436 |
NN |
denotes |
Xpd†XPCS |
T4877 |
436-438 |
, |
denotes |
, |
T4878 |
438-441 |
CC |
denotes |
and |
T4879 |
442-448 |
NN |
denotes |
Xpd†XP |
T4880 |
457-461 |
RBS |
denotes |
most |
T4881 |
462-468 |
RB |
denotes |
likely |
T4882 |
478-479 |
DT |
denotes |
a |
T4883 |
480-486 |
NN |
denotes |
defect |
T4884 |
487-489 |
IN |
denotes |
in |
T4885 |
490-495 |
JJ |
denotes |
basal |
T4886 |
496-509 |
NN |
denotes |
transcription |
T4887 |
510-514 |
WDT |
denotes |
that |
T4888 |
515-517 |
VBZ |
denotes |
is |
T4889 |
518-530 |
JJ |
denotes |
incompatible |
T4890 |
531-535 |
IN |
denotes |
with |
T4891 |
536-540 |
NN |
denotes |
life |
T4892 |
540-541 |
. |
denotes |
. |
T4893 |
541-662 |
sentence |
denotes |
In XpdTTD/ †XPCS and XpdTTD/ †XP compound heterozygous mice, embryonic lethality was fully rescued by the XpdTTD allele. |
T4894 |
542-544 |
IN |
denotes |
In |
T4895 |
633-640 |
VBN |
denotes |
rescued |
T4896 |
545-551 |
NN |
denotes |
XpdTTD |
T4897 |
552-558 |
NN |
denotes |
†XPCS |
T4898 |
551-552 |
HYPH |
denotes |
/ |
T4899 |
597-601 |
NNS |
denotes |
mice |
T4900 |
559-562 |
CC |
denotes |
and |
T4901 |
563-569 |
NN |
denotes |
XpdTTD |
T4902 |
570-574 |
NN |
denotes |
†XP |
T4903 |
569-570 |
HYPH |
denotes |
/ |
T4904 |
575-583 |
NN |
denotes |
compound |
T4905 |
584-596 |
JJ |
denotes |
heterozygous |
T4906 |
601-603 |
, |
denotes |
, |
T4907 |
603-612 |
JJ |
denotes |
embryonic |
T4908 |
613-622 |
NN |
denotes |
lethality |
T4909 |
623-626 |
VBD |
denotes |
was |
T4910 |
627-632 |
RB |
denotes |
fully |
T4911 |
641-643 |
IN |
denotes |
by |
T4912 |
644-647 |
DT |
denotes |
the |
T4913 |
655-661 |
NN |
denotes |
allele |
T4914 |
648-654 |
NN |
denotes |
XpdTTD |
T4915 |
661-662 |
. |
denotes |
. |
T4916 |
662-927 |
sentence |
denotes |
Because embryonic lethality was also fully rescued in XpdTTD/KO hemizygous mice, the XpdTTD allele can be considered as wt and thus dominant to each of the homozygous lethal alleles (XpdKO, Xpd†XPCS, and Xpd†XP) with respect to this particular phenotype (Table 2). |
T4917 |
663-670 |
IN |
denotes |
Because |
T4918 |
706-713 |
VBN |
denotes |
rescued |
T4919 |
671-680 |
JJ |
denotes |
embryonic |
T4920 |
681-690 |
NN |
denotes |
lethality |
T4921 |
691-694 |
VBD |
denotes |
was |
T4922 |
695-699 |
RB |
denotes |
also |
T4923 |
700-705 |
RB |
denotes |
fully |
T4924 |
769-779 |
VBN |
denotes |
considered |
T4925 |
714-716 |
IN |
denotes |
in |
T4926 |
717-723 |
NN |
denotes |
XpdTTD |
T4927 |
724-726 |
NN |
denotes |
KO |
T4928 |
723-724 |
HYPH |
denotes |
/ |
T4929 |
738-742 |
NNS |
denotes |
mice |
T4930 |
727-737 |
JJ |
denotes |
hemizygous |
T4931 |
742-744 |
, |
denotes |
, |
T4932 |
744-747 |
DT |
denotes |
the |
T4933 |
755-761 |
NN |
denotes |
allele |
T4934 |
748-754 |
NN |
denotes |
XpdTTD |
T4935 |
762-765 |
MD |
denotes |
can |
T4936 |
766-768 |
VB |
denotes |
be |
T4937 |
780-782 |
IN |
denotes |
as |
T4938 |
783-785 |
NN |
denotes |
wt |
T4939 |
786-789 |
CC |
denotes |
and |
T4940 |
790-794 |
RB |
denotes |
thus |
T4941 |
795-803 |
JJ |
denotes |
dominant |
T4942 |
804-806 |
IN |
denotes |
to |
T4943 |
807-811 |
DT |
denotes |
each |
T4944 |
812-814 |
IN |
denotes |
of |
T4945 |
815-818 |
DT |
denotes |
the |
T4946 |
837-844 |
NNS |
denotes |
alleles |
T4947 |
819-829 |
JJ |
denotes |
homozygous |
T4948 |
830-836 |
JJ |
denotes |
lethal |
T4949 |
845-846 |
-LRB- |
denotes |
( |
T4950 |
846-851 |
NN |
denotes |
XpdKO |
T4951 |
851-853 |
, |
denotes |
, |
T4952 |
853-861 |
NN |
denotes |
Xpd†XPCS |
T4953 |
861-863 |
, |
denotes |
, |
T4954 |
863-866 |
CC |
denotes |
and |
T4955 |
867-873 |
NN |
denotes |
Xpd†XP |
T4956 |
873-874 |
-RRB- |
denotes |
) |
T4957 |
875-879 |
IN |
denotes |
with |
T4958 |
880-887 |
NN |
denotes |
respect |
T4959 |
888-890 |
IN |
denotes |
to |
T4960 |
891-895 |
DT |
denotes |
this |
T4961 |
907-916 |
NN |
denotes |
phenotype |
T4962 |
896-906 |
JJ |
denotes |
particular |
T4963 |
917-918 |
-LRB- |
denotes |
( |
T4964 |
918-923 |
NN |
denotes |
Table |
T4965 |
924-925 |
CD |
denotes |
2 |
T4966 |
925-926 |
-RRB- |
denotes |
) |
T4967 |
926-927 |
. |
denotes |
. |
T4968 |
927-1187 |
sentence |
denotes |
TTD-specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind of transcriptional insufficiency caused by depletion of unstable TFIIH during the terminal differentiation of skin, hair-shaft, and blood cells [16,24]. |
T4969 |
928-931 |
NN |
denotes |
TTD |
T4970 |
932-940 |
JJ |
denotes |
specific |
T4971 |
931-932 |
HYPH |
denotes |
- |
T4972 |
963-971 |
NNS |
denotes |
features |
T4973 |
941-950 |
JJ |
denotes |
cutaneous |
T4974 |
951-954 |
CC |
denotes |
and |
T4975 |
955-962 |
JJ |
denotes |
anaemic |
T4976 |
996-1003 |
VBN |
denotes |
thought |
T4977 |
971-973 |
, |
denotes |
, |
T4978 |
973-975 |
IN |
denotes |
on |
T4979 |
976-979 |
DT |
denotes |
the |
T4980 |
986-990 |
NN |
denotes |
hand |
T4981 |
980-985 |
JJ |
denotes |
other |
T4982 |
990-992 |
, |
denotes |
, |
T4983 |
992-995 |
VBP |
denotes |
are |
T4984 |
1004-1006 |
TO |
denotes |
to |
T4985 |
1007-1013 |
VB |
denotes |
result |
T4986 |
1014-1018 |
IN |
denotes |
from |
T4987 |
1019-1020 |
DT |
denotes |
a |
T4988 |
1030-1034 |
NN |
denotes |
kind |
T4989 |
1021-1029 |
JJ |
denotes |
specific |
T4990 |
1035-1037 |
IN |
denotes |
of |
T4991 |
1038-1053 |
JJ |
denotes |
transcriptional |
T4992 |
1054-1067 |
NN |
denotes |
insufficiency |
T4993 |
1068-1074 |
VBN |
denotes |
caused |
T4994 |
1075-1077 |
IN |
denotes |
by |
T4995 |
1078-1087 |
NN |
denotes |
depletion |
T4996 |
1088-1090 |
IN |
denotes |
of |
T4997 |
1091-1099 |
JJ |
denotes |
unstable |
T4998 |
1100-1105 |
NN |
denotes |
TFIIH |
T4999 |
1106-1112 |
IN |
denotes |
during |
T5000 |
1113-1116 |
DT |
denotes |
the |
T5001 |
1126-1141 |
NN |
denotes |
differentiation |
T5002 |
1117-1125 |
JJ |
denotes |
terminal |
T5003 |
1142-1144 |
IN |
denotes |
of |
T5004 |
1145-1149 |
NN |
denotes |
skin |
T5005 |
1173-1178 |
NNS |
denotes |
cells |
T5006 |
1149-1151 |
, |
denotes |
, |
T5007 |
1151-1155 |
NN |
denotes |
hair |
T5008 |
1156-1161 |
NN |
denotes |
shaft |
T5009 |
1155-1156 |
HYPH |
denotes |
- |
T5010 |
1161-1163 |
, |
denotes |
, |
T5011 |
1163-1166 |
CC |
denotes |
and |
T5012 |
1167-1172 |
NN |
denotes |
blood |
T5013 |
1179-1180 |
-LRB- |
denotes |
[ |
T5014 |
1183-1185 |
CD |
denotes |
24 |
T5015 |
1180-1182 |
CD |
denotes |
16 |
T5016 |
1182-1183 |
, |
denotes |
, |
T5017 |
1185-1186 |
-RRB- |
denotes |
] |
T5018 |
1186-1187 |
. |
denotes |
. |
T5019 |
1187-1432 |
sentence |
denotes |
In compound heterozygous mice, both homozygous lethal Xpd†XPCS and Xpd†XP alleles were able to alleviate XpdTTD-specific cutaneous and anaemic features and can thus be defined as dominant over the XpdTTD allele with respect to these phenotypes. |
T5020 |
1188-1190 |
IN |
denotes |
In |
T5021 |
1270-1274 |
VBD |
denotes |
were |
T5022 |
1191-1199 |
NN |
denotes |
compound |
T5023 |
1213-1217 |
NNS |
denotes |
mice |
T5024 |
1200-1212 |
JJ |
denotes |
heterozygous |
T5025 |
1217-1219 |
, |
denotes |
, |
T5026 |
1219-1223 |
DT |
denotes |
both |
T5027 |
1262-1269 |
NNS |
denotes |
alleles |
T5028 |
1224-1234 |
JJ |
denotes |
homozygous |
T5029 |
1235-1241 |
JJ |
denotes |
lethal |
T5030 |
1242-1250 |
NN |
denotes |
Xpd†XPCS |
T5031 |
1251-1254 |
CC |
denotes |
and |
T5032 |
1255-1261 |
NN |
denotes |
Xpd†XP |
T5033 |
1275-1279 |
JJ |
denotes |
able |
T5034 |
1280-1282 |
TO |
denotes |
to |
T5035 |
1283-1292 |
VB |
denotes |
alleviate |
T5036 |
1293-1299 |
NN |
denotes |
XpdTTD |
T5037 |
1300-1308 |
JJ |
denotes |
specific |
T5038 |
1299-1300 |
HYPH |
denotes |
- |
T5039 |
1331-1339 |
NNS |
denotes |
features |
T5040 |
1309-1318 |
JJ |
denotes |
cutaneous |
T5041 |
1319-1322 |
CC |
denotes |
and |
T5042 |
1323-1330 |
JJ |
denotes |
anaemic |
T5043 |
1340-1343 |
CC |
denotes |
and |
T5044 |
1344-1347 |
MD |
denotes |
can |
T5045 |
1356-1363 |
VBN |
denotes |
defined |
T5046 |
1348-1352 |
RB |
denotes |
thus |
T5047 |
1353-1355 |
VB |
denotes |
be |
T5048 |
1364-1366 |
IN |
denotes |
as |
T5049 |
1367-1375 |
JJ |
denotes |
dominant |
T5050 |
1376-1380 |
IN |
denotes |
over |
T5051 |
1381-1384 |
DT |
denotes |
the |
T5052 |
1392-1398 |
NN |
denotes |
allele |
T5053 |
1385-1391 |
NN |
denotes |
XpdTTD |
T5054 |
1399-1403 |
IN |
denotes |
with |
T5055 |
1404-1411 |
NN |
denotes |
respect |
T5056 |
1412-1414 |
IN |
denotes |
to |
T5057 |
1415-1420 |
DT |
denotes |
these |
T5058 |
1421-1431 |
NNS |
denotes |
phenotypes |
T5059 |
1431-1432 |
. |
denotes |
. |
T5060 |
1432-1649 |
sentence |
denotes |
We conclude that the defects leading to embryonic lethality and aberrant terminal differentiation of the skin, hair, and blood represent two qualitatively and/or quantitatively different transcriptional deficiencies. |
T5061 |
1433-1435 |
PRP |
denotes |
We |
T5062 |
1436-1444 |
VBP |
denotes |
conclude |
T5063 |
1445-1449 |
IN |
denotes |
that |
T5064 |
1560-1569 |
VBP |
denotes |
represent |
T5065 |
1450-1453 |
DT |
denotes |
the |
T5066 |
1454-1461 |
NNS |
denotes |
defects |
T5067 |
1462-1469 |
VBG |
denotes |
leading |
T5068 |
1470-1472 |
IN |
denotes |
to |
T5069 |
1473-1482 |
JJ |
denotes |
embryonic |
T5070 |
1483-1492 |
NN |
denotes |
lethality |
T5071 |
1493-1496 |
CC |
denotes |
and |
T5072 |
1497-1505 |
JJ |
denotes |
aberrant |
T5073 |
1515-1530 |
NN |
denotes |
differentiation |
T5074 |
1506-1514 |
JJ |
denotes |
terminal |
T5075 |
1531-1533 |
IN |
denotes |
of |
T5076 |
1534-1537 |
DT |
denotes |
the |
T5077 |
1538-1542 |
NN |
denotes |
skin |
T5078 |
1542-1544 |
, |
denotes |
, |
T5079 |
1544-1548 |
NN |
denotes |
hair |
T5080 |
1548-1550 |
, |
denotes |
, |
T5081 |
1550-1553 |
CC |
denotes |
and |
T5082 |
1554-1559 |
NN |
denotes |
blood |
T5083 |
1570-1573 |
CD |
denotes |
two |
T5084 |
1636-1648 |
NNS |
denotes |
deficiencies |
T5085 |
1574-1587 |
RB |
denotes |
qualitatively |
T5086 |
1610-1619 |
JJ |
denotes |
different |
T5087 |
1588-1591 |
CC |
denotes |
and |
T5088 |
1591-1592 |
HYPH |
denotes |
/ |
T5089 |
1592-1594 |
CC |
denotes |
or |
T5090 |
1595-1609 |
RB |
denotes |
quantitatively |
T5091 |
1620-1635 |
JJ |
denotes |
transcriptional |
T5092 |
1648-1649 |
. |
denotes |
. |
T5093 |
1649-1840 |
sentence |
denotes |
During early embryonic development, XpdTTD is dominant over the Xpd†XPCS and Xpd†XP alleles, whereas later in the ontogenesis of skin, hair-shaft, and blood cells, the situation is reversed. |
T5094 |
1650-1656 |
IN |
denotes |
During |
T5095 |
1693-1695 |
VBZ |
denotes |
is |
T5096 |
1657-1662 |
JJ |
denotes |
early |
T5097 |
1673-1684 |
NN |
denotes |
development |
T5098 |
1663-1672 |
JJ |
denotes |
embryonic |
T5099 |
1684-1686 |
, |
denotes |
, |
T5100 |
1686-1692 |
NN |
denotes |
XpdTTD |
T5101 |
1696-1704 |
JJ |
denotes |
dominant |
T5102 |
1705-1709 |
IN |
denotes |
over |
T5103 |
1710-1713 |
DT |
denotes |
the |
T5104 |
1734-1741 |
NNS |
denotes |
alleles |
T5105 |
1714-1722 |
NN |
denotes |
Xpd†XPCS |
T5106 |
1723-1726 |
CC |
denotes |
and |
T5107 |
1727-1733 |
NN |
denotes |
Xpd†XP |
T5108 |
1741-1743 |
, |
denotes |
, |
T5109 |
1743-1750 |
IN |
denotes |
whereas |
T5110 |
1831-1839 |
VBN |
denotes |
reversed |
T5111 |
1751-1756 |
RB |
denotes |
later |
T5112 |
1757-1759 |
IN |
denotes |
in |
T5113 |
1760-1763 |
DT |
denotes |
the |
T5114 |
1764-1775 |
NN |
denotes |
ontogenesis |
T5115 |
1776-1778 |
IN |
denotes |
of |
T5116 |
1779-1783 |
NN |
denotes |
skin |
T5117 |
1783-1785 |
, |
denotes |
, |
T5118 |
1785-1789 |
NN |
denotes |
hair |
T5119 |
1790-1795 |
NN |
denotes |
shaft |
T5120 |
1789-1790 |
HYPH |
denotes |
- |
T5121 |
1795-1797 |
, |
denotes |
, |
T5122 |
1797-1800 |
CC |
denotes |
and |
T5123 |
1801-1806 |
NN |
denotes |
blood |
T5124 |
1807-1812 |
NNS |
denotes |
cells |
T5125 |
1812-1814 |
, |
denotes |
, |
T5126 |
1814-1817 |
DT |
denotes |
the |
T5127 |
1818-1827 |
NN |
denotes |
situation |
T5128 |
1828-1830 |
VBZ |
denotes |
is |
T5129 |
1839-1840 |
. |
denotes |
. |
T5130 |
1840-2083 |
sentence |
denotes |
In its role in the repair of UV photolesions, the Xpd†XPCS allele imparted a clear UV survival benefit over a single XpdTTD allele or two XpdXPCS alleles independent of expression levels, which is consistent with interallelic complementation. |
T5131 |
1841-1843 |
IN |
denotes |
In |
T5132 |
1907-1915 |
VBD |
denotes |
imparted |
T5133 |
1844-1847 |
PRP$ |
denotes |
its |
T5134 |
1848-1852 |
NN |
denotes |
role |
T5135 |
1853-1855 |
IN |
denotes |
in |
T5136 |
1856-1859 |
DT |
denotes |
the |
T5137 |
1860-1866 |
NN |
denotes |
repair |
T5138 |
1867-1869 |
IN |
denotes |
of |
T5139 |
1870-1872 |
NN |
denotes |
UV |
T5140 |
1873-1885 |
NNS |
denotes |
photolesions |
T5141 |
1885-1887 |
, |
denotes |
, |
T5142 |
1887-1890 |
DT |
denotes |
the |
T5143 |
1900-1906 |
NN |
denotes |
allele |
T5144 |
1891-1899 |
NN |
denotes |
Xpd†XPCS |
T5145 |
1916-1917 |
DT |
denotes |
a |
T5146 |
1936-1943 |
NN |
denotes |
benefit |
T5147 |
1918-1923 |
JJ |
denotes |
clear |
T5148 |
1924-1926 |
NN |
denotes |
UV |
T5149 |
1927-1935 |
NN |
denotes |
survival |
T5150 |
1944-1948 |
IN |
denotes |
over |
T5151 |
1949-1950 |
DT |
denotes |
a |
T5152 |
1965-1971 |
NN |
denotes |
allele |
T5153 |
1951-1957 |
JJ |
denotes |
single |
T5154 |
1958-1964 |
NN |
denotes |
XpdTTD |
T5155 |
1972-1974 |
CC |
denotes |
or |
T5156 |
1975-1978 |
CD |
denotes |
two |
T5157 |
1987-1994 |
NNS |
denotes |
alleles |
T5158 |
1979-1986 |
NN |
denotes |
XpdXPCS |
T5159 |
1995-2006 |
JJ |
denotes |
independent |
T5160 |
2007-2009 |
IN |
denotes |
of |
T5161 |
2010-2020 |
NN |
denotes |
expression |
T5162 |
2021-2027 |
NNS |
denotes |
levels |
T5163 |
2027-2029 |
, |
denotes |
, |
T5164 |
2029-2034 |
WDT |
denotes |
which |
T5165 |
2035-2037 |
VBZ |
denotes |
is |
T5166 |
2038-2048 |
JJ |
denotes |
consistent |
T5167 |
2049-2053 |
IN |
denotes |
with |
T5168 |
2054-2066 |
JJ |
denotes |
interallelic |
T5169 |
2067-2082 |
NN |
denotes |
complementation |
T5170 |
2082-2083 |
. |
denotes |
. |
T5171 |
2083-2303 |
sentence |
denotes |
However, the observation that no other cellular or biochemical UV-related parameters were improved in XpdTTD/ †XPCS argues against complementation of this repair activity in the rescue of TTD progeroid symptoms in vivo. |
T5172 |
2084-2091 |
RB |
denotes |
However |
T5173 |
2200-2206 |
VBZ |
denotes |
argues |
T5174 |
2091-2093 |
, |
denotes |
, |
T5175 |
2093-2096 |
DT |
denotes |
the |
T5176 |
2097-2108 |
NN |
denotes |
observation |
T5177 |
2109-2113 |
IN |
denotes |
that |
T5178 |
2174-2182 |
VBN |
denotes |
improved |
T5179 |
2114-2116 |
DT |
denotes |
no |
T5180 |
2158-2168 |
NNS |
denotes |
parameters |
T5181 |
2117-2122 |
JJ |
denotes |
other |
T5182 |
2123-2131 |
JJ |
denotes |
cellular |
T5183 |
2132-2134 |
CC |
denotes |
or |
T5184 |
2135-2146 |
JJ |
denotes |
biochemical |
T5185 |
2147-2149 |
NN |
denotes |
UV |
T5186 |
2150-2157 |
VBN |
denotes |
related |
T5187 |
2149-2150 |
HYPH |
denotes |
- |
T5188 |
2169-2173 |
VBD |
denotes |
were |
T5189 |
2183-2185 |
IN |
denotes |
in |
T5190 |
2186-2192 |
NN |
denotes |
XpdTTD |
T5191 |
2193-2199 |
NN |
denotes |
†XPCS |
T5192 |
2192-2193 |
HYPH |
denotes |
/ |
T5193 |
2207-2214 |
IN |
denotes |
against |
T5194 |
2215-2230 |
NN |
denotes |
complementation |
T5195 |
2231-2233 |
IN |
denotes |
of |
T5196 |
2234-2238 |
DT |
denotes |
this |
T5197 |
2246-2254 |
NN |
denotes |
activity |
T5198 |
2239-2245 |
NN |
denotes |
repair |
T5199 |
2255-2257 |
IN |
denotes |
in |
T5200 |
2258-2261 |
DT |
denotes |
the |
T5201 |
2262-2268 |
NN |
denotes |
rescue |
T5202 |
2269-2271 |
IN |
denotes |
of |
T5203 |
2272-2275 |
NN |
denotes |
TTD |
T5204 |
2286-2294 |
NNS |
denotes |
symptoms |
T5205 |
2276-2285 |
JJ |
denotes |
progeroid |
T5206 |
2295-2297 |
FW |
denotes |
in |
T5207 |
2298-2302 |
FW |
denotes |
vivo |
T5208 |
2302-2303 |
. |
denotes |
. |
R3180 |
T4806 |
T4805 |
prep |
in,TFIIH |
R3181 |
T4807 |
T4806 |
pobj |
Transcription,in |
R3182 |
T4808 |
T4807 |
cc |
and,Transcription |
R3183 |
T4809 |
T4807 |
conj |
Repair,Transcription |
R3184 |
T4810 |
T4805 |
punct |
: ,TFIIH |
R3185 |
T4811 |
T4805 |
appos |
Mechanisms,TFIIH |
R3186 |
T4812 |
T4811 |
prep |
of,Mechanisms |
R3187 |
T4813 |
T4814 |
compound |
XPD,Pleiotropy |
R3188 |
T4814 |
T4812 |
pobj |
Pleiotropy,of |
R3189 |
T4815 |
T4814 |
compound |
Disease,Pleiotropy |
R3190 |
T4817 |
T4818 |
nsubj |
We,observed |
R3191 |
T4819 |
T4818 |
dobj |
differences,observed |
R3192 |
T4820 |
T4819 |
prep |
in,differences |
R3193 |
T4821 |
T4822 |
det |
the,ability |
R3194 |
T4822 |
T4820 |
pobj |
ability,in |
R3195 |
T4823 |
T4822 |
prep |
of,ability |
R3196 |
T4824 |
T4823 |
pobj |
XpdTTD,of |
R3197 |
T4825 |
T4824 |
cc |
versus,XpdTTD |
R3198 |
T4826 |
T4827 |
amod |
homozygous,alleles |
R3199 |
T4827 |
T4824 |
conj |
alleles,XpdTTD |
R3200 |
T4828 |
T4827 |
amod |
lethal,alleles |
R3201 |
T4829 |
T4827 |
nmod |
Xpd†XPCS,alleles |
R3202 |
T4830 |
T4829 |
cc |
and,Xpd†XPCS |
R3203 |
T4831 |
T4829 |
conj |
Xpd†XP,Xpd†XPCS |
R3204 |
T4832 |
T4833 |
aux |
to,function |
R3205 |
T4833 |
T4822 |
acl |
function,ability |
R3206 |
T4834 |
T4833 |
prep |
in,function |
R3207 |
T4835 |
T4836 |
nummod |
two,phenotypes |
R3208 |
T4836 |
T4834 |
pobj |
phenotypes,in |
R3209 |
T4837 |
T4838 |
npadvmod |
transcription,related |
R3210 |
T4838 |
T4836 |
amod |
related,phenotypes |
R3211 |
T4839 |
T4838 |
punct |
-,related |
R3212 |
T4840 |
T4836 |
acl |
separated,phenotypes |
R3213 |
T4841 |
T4840 |
prep |
in,separated |
R3214 |
T4842 |
T4843 |
det |
the,organism |
R3215 |
T4843 |
T4841 |
pobj |
organism,in |
R3216 |
T4844 |
T4840 |
prep |
by,separated |
R3217 |
T4845 |
T4846 |
preconj |
both,time |
R3218 |
T4846 |
T4844 |
pobj |
time,by |
R3219 |
T4847 |
T4846 |
cc |
and,time |
R3220 |
T4848 |
T4846 |
conj |
space,time |
R3221 |
T4849 |
T4819 |
punct |
: ,differences |
R3222 |
T4850 |
T4851 |
amod |
embryonic,lethality |
R3223 |
T4851 |
T4819 |
appos |
lethality,differences |
R3224 |
T4852 |
T4851 |
cc |
and,lethality |
R3225 |
T4853 |
T4854 |
amod |
terminal,differentiation |
R3226 |
T4854 |
T4851 |
conj |
differentiation,lethality |
R3227 |
T4855 |
T4854 |
prep |
of,differentiation |
R3228 |
T4856 |
T4857 |
amod |
enucleating,skin |
R3229 |
T4857 |
T4855 |
pobj |
skin,of |
R3230 |
T4858 |
T4857 |
cc |
and,skin |
R3231 |
T4859 |
T4860 |
compound |
blood,cells |
R3232 |
T4860 |
T4857 |
conj |
cells,skin |
R3233 |
T4861 |
T4818 |
punct |
.,observed |
R3234 |
T4863 |
T4864 |
det |
The,lethality |
R3235 |
T4864 |
T4869 |
nsubj |
lethality,reflects |
R3236 |
T4865 |
T4866 |
nmod |
preblastocyst,stage |
R3237 |
T4866 |
T4864 |
nmod |
stage,lethality |
R3238 |
T4867 |
T4866 |
punct |
-,stage |
R3239 |
T4868 |
T4864 |
amod |
homozygous,lethality |
R3240 |
T4870 |
T4864 |
acl |
shared,lethality |
R3241 |
T4871 |
T4870 |
agent |
by,shared |
R3242 |
T4872 |
T4873 |
det |
the,alleles |
R3243 |
T4873 |
T4871 |
pobj |
alleles,by |
R3244 |
T4874 |
T4873 |
nmod |
XpdKO,alleles |
R3245 |
T4875 |
T4874 |
punct |
", ",XpdKO |
R3246 |
T4876 |
T4874 |
conj |
Xpd†XPCS,XpdKO |
R3247 |
T4877 |
T4876 |
punct |
", ",Xpd†XPCS |
R3248 |
T4878 |
T4876 |
cc |
and,Xpd†XPCS |
R3249 |
T4879 |
T4876 |
conj |
Xpd†XP,Xpd†XPCS |
R3250 |
T4880 |
T4881 |
advmod |
most,likely |
R3251 |
T4881 |
T4869 |
advmod |
likely,reflects |
R3252 |
T4882 |
T4883 |
det |
a,defect |
R3253 |
T4883 |
T4869 |
dobj |
defect,reflects |
R3254 |
T4884 |
T4883 |
prep |
in,defect |
R3255 |
T4885 |
T4886 |
amod |
basal,transcription |
R3256 |
T4886 |
T4884 |
pobj |
transcription,in |
R3257 |
T4887 |
T4888 |
dep |
that,is |
R3258 |
T4888 |
T4883 |
relcl |
is,defect |
R3259 |
T4889 |
T4888 |
acomp |
incompatible,is |
R3260 |
T4890 |
T4889 |
prep |
with,incompatible |
R3261 |
T4891 |
T4890 |
pobj |
life,with |
R3262 |
T4892 |
T4869 |
punct |
.,reflects |
R3263 |
T4894 |
T4895 |
prep |
In,rescued |
R3264 |
T4896 |
T4897 |
nmod |
XpdTTD, †XPCS |
R3265 |
T4897 |
T4899 |
nmod |
†XPCS,mice |
R3266 |
T4898 |
T4897 |
punct |
/, †XPCS |
R3267 |
T4899 |
T4894 |
pobj |
mice,In |
R3268 |
T4900 |
T4897 |
cc |
and, †XPCS |
R3269 |
T4901 |
T4902 |
compound |
XpdTTD, †XP |
R3270 |
T4902 |
T4897 |
conj |
†XP, †XPCS |
R3271 |
T4903 |
T4902 |
punct |
/, †XP |
R3272 |
T4904 |
T4899 |
nmod |
compound,mice |
R3273 |
T4905 |
T4899 |
amod |
heterozygous,mice |
R3274 |
T4906 |
T4895 |
punct |
", ",rescued |
R3275 |
T4907 |
T4908 |
amod |
embryonic,lethality |
R3276 |
T4908 |
T4895 |
nsubjpass |
lethality,rescued |
R3277 |
T4909 |
T4895 |
auxpass |
was,rescued |
R3278 |
T4910 |
T4895 |
advmod |
fully,rescued |
R3279 |
T4911 |
T4895 |
agent |
by,rescued |
R3280 |
T4912 |
T4913 |
det |
the,allele |
R3281 |
T4913 |
T4911 |
pobj |
allele,by |
R3282 |
T4914 |
T4913 |
compound |
XpdTTD,allele |
R3283 |
T4915 |
T4895 |
punct |
.,rescued |
R3284 |
T4917 |
T4918 |
mark |
Because,rescued |
R3285 |
T4918 |
T4924 |
advcl |
rescued,considered |
R3286 |
T4919 |
T4920 |
amod |
embryonic,lethality |
R3287 |
T4920 |
T4918 |
nsubjpass |
lethality,rescued |
R3288 |
T4921 |
T4918 |
auxpass |
was,rescued |
R3289 |
T4922 |
T4918 |
advmod |
also,rescued |
R3290 |
T4923 |
T4918 |
advmod |
fully,rescued |
R3291 |
T4925 |
T4918 |
prep |
in,rescued |
R3292 |
T4926 |
T4927 |
nmod |
XpdTTD,KO |
R3293 |
T4927 |
T4929 |
nmod |
KO,mice |
R3294 |
T4928 |
T4927 |
punct |
/,KO |
R3295 |
T4929 |
T4925 |
pobj |
mice,in |
R3296 |
T4930 |
T4929 |
amod |
hemizygous,mice |
R3297 |
T4931 |
T4924 |
punct |
", ",considered |
R3298 |
T4932 |
T4933 |
det |
the,allele |
R3299 |
T4933 |
T4924 |
nsubjpass |
allele,considered |
R3300 |
T4934 |
T4933 |
compound |
XpdTTD,allele |
R3301 |
T4935 |
T4924 |
aux |
can,considered |
R3302 |
T4936 |
T4924 |
auxpass |
be,considered |
R3303 |
T4937 |
T4924 |
prep |
as,considered |
R3304 |
T4938 |
T4937 |
pobj |
wt,as |
R3305 |
T4939 |
T4938 |
cc |
and,wt |
R3306 |
T4940 |
T4941 |
advmod |
thus,dominant |
R3307 |
T4941 |
T4938 |
conj |
dominant,wt |
R3308 |
T4942 |
T4941 |
prep |
to,dominant |
R3309 |
T4943 |
T4942 |
pobj |
each,to |
R3310 |
T4944 |
T4943 |
prep |
of,each |
R3311 |
T4945 |
T4946 |
det |
the,alleles |
R3312 |
T4946 |
T4944 |
pobj |
alleles,of |
R3313 |
T4947 |
T4946 |
amod |
homozygous,alleles |
R3314 |
T4948 |
T4946 |
amod |
lethal,alleles |
R3315 |
T4949 |
T4950 |
punct |
(,XpdKO |
R3316 |
T4950 |
T4946 |
parataxis |
XpdKO,alleles |
R3317 |
T4951 |
T4950 |
punct |
", ",XpdKO |
R3318 |
T4952 |
T4950 |
conj |
Xpd†XPCS,XpdKO |
R3319 |
T4953 |
T4952 |
punct |
", ",Xpd†XPCS |
R3320 |
T4954 |
T4952 |
cc |
and,Xpd†XPCS |
R3321 |
T4955 |
T4952 |
conj |
Xpd†XP,Xpd†XPCS |
R3322 |
T4956 |
T4950 |
punct |
),XpdKO |
R3323 |
T4957 |
T4941 |
prep |
with,dominant |
R3324 |
T4958 |
T4957 |
pobj |
respect,with |
R3325 |
T4959 |
T4958 |
prep |
to,respect |
R3326 |
T4960 |
T4961 |
det |
this,phenotype |
R3327 |
T4961 |
T4959 |
pobj |
phenotype,to |
R3328 |
T4962 |
T4961 |
amod |
particular,phenotype |
R3329 |
T4963 |
T4964 |
punct |
(,Table |
R3330 |
T4964 |
T4924 |
parataxis |
Table,considered |
R3331 |
T4965 |
T4964 |
nummod |
2,Table |
R3332 |
T4966 |
T4964 |
punct |
),Table |
R3333 |
T4967 |
T4924 |
punct |
.,considered |
R3334 |
T4969 |
T4970 |
npadvmod |
TTD,specific |
R3335 |
T4970 |
T4972 |
amod |
specific,features |
R3336 |
T4971 |
T4970 |
punct |
-,specific |
R3337 |
T4972 |
T4976 |
nsubjpass |
features,thought |
R3338 |
T4973 |
T4972 |
amod |
cutaneous,features |
R3339 |
T4974 |
T4973 |
cc |
and,cutaneous |
R3340 |
T4975 |
T4973 |
conj |
anaemic,cutaneous |
R3341 |
T4977 |
T4976 |
punct |
", ",thought |
R3342 |
T4978 |
T4976 |
prep |
on,thought |
R3343 |
T4979 |
T4980 |
det |
the,hand |
R3344 |
T4980 |
T4978 |
pobj |
hand,on |
R3345 |
T4981 |
T4980 |
amod |
other,hand |
R3346 |
T4982 |
T4976 |
punct |
", ",thought |
R3347 |
T4983 |
T4976 |
auxpass |
are,thought |
R3348 |
T4984 |
T4985 |
aux |
to,result |
R3349 |
T4985 |
T4976 |
xcomp |
result,thought |
R3350 |
T4986 |
T4985 |
prep |
from,result |
R3351 |
T4987 |
T4988 |
det |
a,kind |
R3352 |
T4988 |
T4986 |
pobj |
kind,from |
R3353 |
T4989 |
T4988 |
amod |
specific,kind |
R3354 |
T4990 |
T4988 |
prep |
of,kind |
R3355 |
T4991 |
T4992 |
amod |
transcriptional,insufficiency |
R3356 |
T4992 |
T4990 |
pobj |
insufficiency,of |
R3357 |
T4993 |
T4988 |
acl |
caused,kind |
R3358 |
T4994 |
T4993 |
agent |
by,caused |
R3359 |
T4995 |
T4994 |
pobj |
depletion,by |
R3360 |
T4996 |
T4995 |
prep |
of,depletion |
R3361 |
T4997 |
T4998 |
amod |
unstable,TFIIH |
R3362 |
T4998 |
T4996 |
pobj |
TFIIH,of |
R3363 |
T4999 |
T4995 |
prep |
during,depletion |
R3364 |
T5000 |
T5001 |
det |
the,differentiation |
R3365 |
T5001 |
T4999 |
pobj |
differentiation,during |
R3366 |
T5002 |
T5001 |
amod |
terminal,differentiation |
R3367 |
T5003 |
T5001 |
prep |
of,differentiation |
R3368 |
T5004 |
T5005 |
nmod |
skin,cells |
R3369 |
T5005 |
T5003 |
pobj |
cells,of |
R3370 |
T5006 |
T5004 |
punct |
", ",skin |
R3371 |
T5007 |
T5008 |
compound |
hair,shaft |
R3372 |
T5008 |
T5004 |
conj |
shaft,skin |
R3373 |
T5009 |
T5008 |
punct |
-,shaft |
R3374 |
T5010 |
T5008 |
punct |
", ",shaft |
R3375 |
T5011 |
T5008 |
cc |
and,shaft |
R3376 |
T5012 |
T5008 |
conj |
blood,shaft |
R3377 |
T5013 |
T5014 |
punct |
[,24 |
R3378 |
T5014 |
T4976 |
parataxis |
24,thought |
R3379 |
T5015 |
T5014 |
nummod |
16,24 |
R3380 |
T5016 |
T5014 |
punct |
",",24 |
R3381 |
T5017 |
T5014 |
punct |
],24 |
R3382 |
T5018 |
T4976 |
punct |
.,thought |
R3383 |
T5020 |
T5021 |
prep |
In,were |
R3384 |
T5022 |
T5023 |
nmod |
compound,mice |
R3385 |
T5023 |
T5020 |
pobj |
mice,In |
R3386 |
T5024 |
T5023 |
amod |
heterozygous,mice |
R3387 |
T5025 |
T5021 |
punct |
", ",were |
R3388 |
T5026 |
T5027 |
det |
both,alleles |
R3389 |
T5027 |
T5021 |
nsubj |
alleles,were |
R3390 |
T5028 |
T5027 |
amod |
homozygous,alleles |
R3391 |
T5029 |
T5027 |
amod |
lethal,alleles |
R3392 |
T5030 |
T5027 |
nmod |
Xpd†XPCS,alleles |
R3393 |
T5031 |
T5030 |
cc |
and,Xpd†XPCS |
R3394 |
T5032 |
T5030 |
conj |
Xpd†XP,Xpd†XPCS |
R3395 |
T5033 |
T5021 |
acomp |
able,were |
R3396 |
T5034 |
T5035 |
aux |
to,alleviate |
R3397 |
T5035 |
T5033 |
xcomp |
alleviate,able |
R3398 |
T5036 |
T5037 |
npadvmod |
XpdTTD,specific |
R3399 |
T5037 |
T5039 |
amod |
specific,features |
R3400 |
T5038 |
T5037 |
punct |
-,specific |
R3401 |
T5039 |
T5035 |
dobj |
features,alleviate |
R3402 |
T5040 |
T5039 |
amod |
cutaneous,features |
R3403 |
T5041 |
T5040 |
cc |
and,cutaneous |
R3404 |
T5042 |
T5040 |
conj |
anaemic,cutaneous |
R3405 |
T5043 |
T5021 |
cc |
and,were |
R3406 |
T5044 |
T5045 |
aux |
can,defined |
R3407 |
T5045 |
T5021 |
conj |
defined,were |
R3408 |
T5046 |
T5045 |
advmod |
thus,defined |
R3409 |
T5047 |
T5045 |
auxpass |
be,defined |
R3410 |
T5048 |
T5045 |
prep |
as,defined |
R3411 |
T5049 |
T5048 |
amod |
dominant,as |
R3412 |
T5050 |
T5045 |
prep |
over,defined |
R3413 |
T5051 |
T5052 |
det |
the,allele |
R3414 |
T5052 |
T5050 |
pobj |
allele,over |
R3415 |
T5053 |
T5052 |
compound |
XpdTTD,allele |
R3416 |
T5054 |
T5045 |
prep |
with,defined |
R3417 |
T5055 |
T5054 |
pobj |
respect,with |
R3418 |
T5056 |
T5055 |
prep |
to,respect |
R3419 |
T5057 |
T5058 |
det |
these,phenotypes |
R3420 |
T5058 |
T5056 |
pobj |
phenotypes,to |
R3421 |
T5059 |
T5021 |
punct |
.,were |
R3422 |
T5061 |
T5062 |
nsubj |
We,conclude |
R3423 |
T5063 |
T5064 |
mark |
that,represent |
R3424 |
T5064 |
T5062 |
ccomp |
represent,conclude |
R3425 |
T5065 |
T5066 |
det |
the,defects |
R3426 |
T5066 |
T5064 |
nsubj |
defects,represent |
R3427 |
T5067 |
T5066 |
acl |
leading,defects |
R3428 |
T5068 |
T5067 |
prep |
to,leading |
R3429 |
T5069 |
T5070 |
amod |
embryonic,lethality |
R3430 |
T5070 |
T5068 |
pobj |
lethality,to |
R3431 |
T5071 |
T5070 |
cc |
and,lethality |
R3432 |
T5072 |
T5073 |
amod |
aberrant,differentiation |
R3433 |
T5073 |
T5070 |
conj |
differentiation,lethality |
R3434 |
T5074 |
T5073 |
amod |
terminal,differentiation |
R3435 |
T5075 |
T5073 |
prep |
of,differentiation |
R3436 |
T5076 |
T5077 |
det |
the,skin |
R3437 |
T5077 |
T5075 |
pobj |
skin,of |
R3438 |
T5078 |
T5077 |
punct |
", ",skin |
R3439 |
T5079 |
T5077 |
conj |
hair,skin |
R3440 |
T5080 |
T5079 |
punct |
", ",hair |
R3441 |
T5081 |
T5079 |
cc |
and,hair |
R3442 |
T5082 |
T5079 |
conj |
blood,hair |
R3443 |
T5083 |
T5084 |
nummod |
two,deficiencies |
R3444 |
T5084 |
T5064 |
dobj |
deficiencies,represent |
R3445 |
T5085 |
T5086 |
advmod |
qualitatively,different |
R3446 |
T5086 |
T5084 |
amod |
different,deficiencies |
R3447 |
T5087 |
T5085 |
cc |
and,qualitatively |
R3448 |
T5088 |
T5087 |
punct |
/,and |
R3449 |
T5089 |
T5087 |
cc |
or,and |
R3450 |
T5090 |
T5085 |
conj |
quantitatively,qualitatively |
R3451 |
T5091 |
T5084 |
amod |
transcriptional,deficiencies |
R3452 |
T5092 |
T5062 |
punct |
.,conclude |
R3453 |
T5094 |
T5095 |
prep |
During,is |
R3454 |
T5096 |
T5097 |
amod |
early,development |
R3455 |
T5097 |
T5094 |
pobj |
development,During |
R3456 |
T5098 |
T5097 |
amod |
embryonic,development |
R3457 |
T5099 |
T5095 |
punct |
", ",is |
R3458 |
T5100 |
T5095 |
nsubj |
XpdTTD,is |
R3459 |
T5101 |
T5095 |
acomp |
dominant,is |
R3460 |
T5102 |
T5101 |
prep |
over,dominant |
R3461 |
T5103 |
T5104 |
det |
the,alleles |
R3462 |
T5104 |
T5102 |
pobj |
alleles,over |
R3463 |
T5105 |
T5104 |
nmod |
Xpd†XPCS,alleles |
R3464 |
T5106 |
T5105 |
cc |
and,Xpd†XPCS |
R3465 |
T5107 |
T5105 |
conj |
Xpd†XP,Xpd†XPCS |
R3466 |
T5108 |
T5095 |
punct |
", ",is |
R3467 |
T5109 |
T5110 |
mark |
whereas,reversed |
R3468 |
T5110 |
T5095 |
advcl |
reversed,is |
R3469 |
T5111 |
T5110 |
advmod |
later,reversed |
R3470 |
T5112 |
T5111 |
prep |
in,later |
R3471 |
T5113 |
T5114 |
det |
the,ontogenesis |
R3472 |
T5114 |
T5112 |
pobj |
ontogenesis,in |
R3473 |
T5115 |
T5114 |
prep |
of,ontogenesis |
R3474 |
T5116 |
T5115 |
pobj |
skin,of |
R3475 |
T5117 |
T5116 |
punct |
", ",skin |
R3476 |
T5118 |
T5119 |
compound |
hair,shaft |
R3477 |
T5119 |
T5116 |
conj |
shaft,skin |
R3478 |
T5120 |
T5119 |
punct |
-,shaft |
R3479 |
T5121 |
T5119 |
punct |
", ",shaft |
R3480 |
T5122 |
T5119 |
cc |
and,shaft |
R3481 |
T5123 |
T5124 |
compound |
blood,cells |
R3482 |
T5124 |
T5119 |
conj |
cells,shaft |
R3483 |
T5125 |
T5110 |
punct |
", ",reversed |
R3484 |
T5126 |
T5127 |
det |
the,situation |
R3485 |
T5127 |
T5110 |
nsubjpass |
situation,reversed |
R3486 |
T5128 |
T5110 |
auxpass |
is,reversed |
R3487 |
T5129 |
T5095 |
punct |
.,is |
R3488 |
T5131 |
T5132 |
prep |
In,imparted |
R3489 |
T5133 |
T5134 |
poss |
its,role |
R3490 |
T5134 |
T5131 |
pobj |
role,In |
R3491 |
T5135 |
T5134 |
prep |
in,role |
R3492 |
T5136 |
T5137 |
det |
the,repair |
R3493 |
T5137 |
T5135 |
pobj |
repair,in |
R3494 |
T5138 |
T5137 |
prep |
of,repair |
R3495 |
T5139 |
T5140 |
compound |
UV,photolesions |
R3496 |
T5140 |
T5138 |
pobj |
photolesions,of |
R3497 |
T5141 |
T5132 |
punct |
", ",imparted |
R3498 |
T5142 |
T5143 |
det |
the,allele |
R3499 |
T5143 |
T5132 |
nsubj |
allele,imparted |
R3500 |
T5144 |
T5143 |
compound |
Xpd†XPCS,allele |
R3501 |
T5145 |
T5146 |
det |
a,benefit |
R3502 |
T5146 |
T5132 |
dobj |
benefit,imparted |
R3503 |
T5147 |
T5146 |
amod |
clear,benefit |
R3504 |
T5148 |
T5146 |
compound |
UV,benefit |
R3505 |
T5149 |
T5146 |
compound |
survival,benefit |
R3506 |
T5150 |
T5146 |
prep |
over,benefit |
R3507 |
T5151 |
T5152 |
det |
a,allele |
R3508 |
T5152 |
T5150 |
pobj |
allele,over |
R3509 |
T5153 |
T5152 |
amod |
single,allele |
R3510 |
T5154 |
T5152 |
compound |
XpdTTD,allele |
R3511 |
T5155 |
T5152 |
cc |
or,allele |
R3512 |
T5156 |
T5157 |
nummod |
two,alleles |
R3513 |
T5157 |
T5152 |
conj |
alleles,allele |
R3514 |
T5158 |
T5157 |
compound |
XpdXPCS,alleles |
R3515 |
T5159 |
T5146 |
amod |
independent,benefit |
R3516 |
T5160 |
T5159 |
prep |
of,independent |
R3517 |
T5161 |
T5162 |
compound |
expression,levels |
R3518 |
T5162 |
T5160 |
pobj |
levels,of |
R3519 |
T5163 |
T5132 |
punct |
", ",imparted |
R3520 |
T5164 |
T5165 |
dep |
which,is |
R3521 |
T5165 |
T5132 |
advcl |
is,imparted |
R3522 |
T5166 |
T5165 |
acomp |
consistent,is |
R3523 |
T5167 |
T5166 |
prep |
with,consistent |
R3524 |
T5168 |
T5169 |
amod |
interallelic,complementation |
R3525 |
T5169 |
T5167 |
pobj |
complementation,with |
R3526 |
T5170 |
T5132 |
punct |
.,imparted |
R3527 |
T5172 |
T5173 |
advmod |
However,argues |
R3528 |
T5174 |
T5173 |
punct |
", ",argues |
R3529 |
T5175 |
T5176 |
det |
the,observation |
R3530 |
T5176 |
T5173 |
nsubj |
observation,argues |
R3531 |
T5177 |
T5178 |
mark |
that,improved |
R3532 |
T5178 |
T5176 |
acl |
improved,observation |
R3533 |
T5179 |
T5180 |
det |
no,parameters |
R3534 |
T5180 |
T5178 |
nsubjpass |
parameters,improved |
R3535 |
T5181 |
T5180 |
amod |
other,parameters |
R3536 |
T5182 |
T5180 |
amod |
cellular,parameters |
R3537 |
T5183 |
T5182 |
cc |
or,cellular |
R3538 |
T5184 |
T5182 |
conj |
biochemical,cellular |
R3539 |
T5185 |
T5186 |
npadvmod |
UV,related |
R3540 |
T5186 |
T5180 |
amod |
related,parameters |
R3541 |
T5187 |
T5186 |
punct |
-,related |
R3542 |
T5188 |
T5178 |
auxpass |
were,improved |
R3543 |
T5189 |
T5178 |
prep |
in,improved |
R3544 |
T5190 |
T5191 |
compound |
XpdTTD, †XPCS |
R3545 |
T5191 |
T5189 |
pobj |
†XPCS,in |
R3546 |
T5192 |
T5191 |
punct |
/, †XPCS |
R3547 |
T5193 |
T5173 |
prep |
against,argues |
R3548 |
T5194 |
T5193 |
pobj |
complementation,against |
R3549 |
T5195 |
T5194 |
prep |
of,complementation |
R3550 |
T5196 |
T5197 |
det |
this,activity |
R3551 |
T5197 |
T5195 |
pobj |
activity,of |
R3552 |
T5198 |
T5197 |
compound |
repair,activity |
R3553 |
T5199 |
T5194 |
prep |
in,complementation |
R3554 |
T5200 |
T5201 |
det |
the,rescue |
R3555 |
T5201 |
T5199 |
pobj |
rescue,in |
R3556 |
T5202 |
T5201 |
prep |
of,rescue |
R3557 |
T5203 |
T5204 |
nmod |
TTD,symptoms |
R3558 |
T5204 |
T5202 |
pobj |
symptoms,of |
R3559 |
T5205 |
T5204 |
amod |
progeroid,symptoms |
R3560 |
T5206 |
T5207 |
advmod |
in,vivo |
R3561 |
T5207 |
T5201 |
advmod |
vivo,rescue |
R3562 |
T5208 |
T5173 |
punct |
.,argues |