Id |
Subject |
Object |
Predicate |
Lexical cue |
T3318 |
0-2 |
PRP |
denotes |
We |
T3319 |
8-14 |
VBD |
denotes |
turned |
T3320 |
3-7 |
RB |
denotes |
next |
T3321 |
15-17 |
IN |
denotes |
to |
T3322 |
18-20 |
NN |
denotes |
UV |
T3323 |
21-26 |
VBN |
denotes |
based |
T3324 |
20-21 |
HYPH |
denotes |
- |
T3325 |
36-42 |
NNS |
denotes |
assays |
T3326 |
27-35 |
JJ |
denotes |
cellular |
T3327 |
43-52 |
VBG |
denotes |
including |
T3328 |
53-64 |
JJ |
denotes |
unscheduled |
T3329 |
69-78 |
NN |
denotes |
synthesis |
T3330 |
65-68 |
NN |
denotes |
DNA |
T3331 |
79-84 |
IN |
denotes |
after |
T3332 |
85-87 |
NN |
denotes |
UV |
T3333 |
88-99 |
NN |
denotes |
irradiation |
T3334 |
100-101 |
-LRB- |
denotes |
( |
T3335 |
104-107 |
NN |
denotes |
UDS |
T3336 |
101-103 |
NN |
denotes |
UV |
T3337 |
103-104 |
HYPH |
denotes |
- |
T3338 |
107-108 |
-RRB- |
denotes |
) |
T3339 |
108-110 |
, |
denotes |
, |
T3340 |
110-118 |
NN |
denotes |
recovery |
T3341 |
119-121 |
IN |
denotes |
of |
T3342 |
122-125 |
NN |
denotes |
RNA |
T3343 |
126-135 |
NN |
denotes |
synthesis |
T3344 |
136-141 |
IN |
denotes |
after |
T3345 |
142-144 |
NN |
denotes |
UV |
T3346 |
145-156 |
NN |
denotes |
irradiation |
T3347 |
157-158 |
-LRB- |
denotes |
( |
T3348 |
161-164 |
NN |
denotes |
RRS |
T3349 |
158-160 |
NN |
denotes |
UV |
T3350 |
160-161 |
HYPH |
denotes |
- |
T3351 |
164-165 |
-RRB- |
denotes |
) |
T3352 |
165-167 |
, |
denotes |
, |
T3353 |
167-170 |
CC |
denotes |
and |
T3354 |
171-173 |
NN |
denotes |
UV |
T3355 |
174-182 |
NN |
denotes |
survival |
T3356 |
182-184 |
, |
denotes |
, |
T3357 |
184-189 |
WDT |
denotes |
which |
T3358 |
190-196 |
VBP |
denotes |
report |
T3359 |
197-199 |
IN |
denotes |
on |
T3360 |
200-203 |
DT |
denotes |
the |
T3361 |
208-219 |
NNS |
denotes |
subpathways |
T3362 |
204-207 |
NN |
denotes |
NER |
T3363 |
220-221 |
-LRB- |
denotes |
( |
T3364 |
235-238 |
NN |
denotes |
NER |
T3365 |
221-227 |
JJ |
denotes |
global |
T3366 |
228-234 |
NN |
denotes |
genome |
T3367 |
239-242 |
CC |
denotes |
and |
T3368 |
243-256 |
NN |
denotes |
transcription |
T3369 |
257-264 |
VBN |
denotes |
coupled |
T3370 |
256-257 |
HYPH |
denotes |
- |
T3371 |
265-268 |
NN |
denotes |
NER |
T3372 |
268-269 |
-RRB- |
denotes |
) |
T3373 |
270-273 |
CC |
denotes |
and |
T3374 |
274-279 |
JJ |
denotes |
total |
T3375 |
280-283 |
NN |
denotes |
NER |
T3376 |
283-285 |
, |
denotes |
, |
T3377 |
285-297 |
RB |
denotes |
respectively |
T3378 |
297-298 |
. |
denotes |
. |
T3379 |
298-424 |
sentence |
denotes |
In none of these assays was the response to UV improved in compound heterozygotes relative to TTD homozygotes (Figure 4A–4C). |
T3380 |
299-301 |
IN |
denotes |
In |
T3381 |
346-354 |
VBN |
denotes |
improved |
T3382 |
302-306 |
NN |
denotes |
none |
T3383 |
307-309 |
IN |
denotes |
of |
T3384 |
310-315 |
DT |
denotes |
these |
T3385 |
316-322 |
NNS |
denotes |
assays |
T3386 |
323-326 |
VBD |
denotes |
was |
T3387 |
327-330 |
DT |
denotes |
the |
T3388 |
331-339 |
NN |
denotes |
response |
T3389 |
340-342 |
IN |
denotes |
to |
T3390 |
343-345 |
NN |
denotes |
UV |
T3391 |
355-357 |
IN |
denotes |
in |
T3392 |
358-366 |
NN |
denotes |
compound |
T3393 |
367-380 |
NNS |
denotes |
heterozygotes |
T3394 |
381-389 |
JJ |
denotes |
relative |
T3395 |
390-392 |
IN |
denotes |
to |
T3396 |
393-396 |
NN |
denotes |
TTD |
T3397 |
397-408 |
NNS |
denotes |
homozygotes |
T3398 |
409-410 |
-LRB- |
denotes |
( |
T3399 |
417-419 |
NN |
denotes |
4A |
T3400 |
410-416 |
NN |
denotes |
Figure |
T3401 |
419-420 |
SYM |
denotes |
– |
T3402 |
420-422 |
NN |
denotes |
4C |
T3403 |
422-423 |
-RRB- |
denotes |
) |
T3404 |
423-424 |
. |
denotes |
. |
T3405 |
424-770 |
sentence |
denotes |
However, unlike the in vivo TTD phenotypes described above, in which XpdTTD/TTD and XpdTTD/KO animals were indistinguishable, XpdTTD dosage effects were observed in UV survival, UV-UDS, and UV-RRS, indicating that cellular parameters as measured in fibroblasts here do not always correlate with the phenotype at the level of the intact organism. |
T3406 |
425-432 |
RB |
denotes |
However |
T3407 |
578-586 |
VBN |
denotes |
observed |
T3408 |
432-434 |
, |
denotes |
, |
T3409 |
434-440 |
IN |
denotes |
unlike |
T3410 |
441-444 |
DT |
denotes |
the |
T3411 |
457-467 |
NNS |
denotes |
phenotypes |
T3412 |
445-447 |
FW |
denotes |
in |
T3413 |
448-452 |
FW |
denotes |
vivo |
T3414 |
453-456 |
NN |
denotes |
TTD |
T3415 |
468-477 |
VBN |
denotes |
described |
T3416 |
478-483 |
RB |
denotes |
above |
T3417 |
483-485 |
, |
denotes |
, |
T3418 |
485-487 |
IN |
denotes |
in |
T3419 |
527-531 |
VBD |
denotes |
were |
T3420 |
488-493 |
WDT |
denotes |
which |
T3421 |
494-500 |
NN |
denotes |
XpdTTD |
T3422 |
501-504 |
NN |
denotes |
TTD |
T3423 |
500-501 |
HYPH |
denotes |
/ |
T3424 |
519-526 |
NNS |
denotes |
animals |
T3425 |
505-508 |
CC |
denotes |
and |
T3426 |
509-515 |
NN |
denotes |
XpdTTD |
T3427 |
516-518 |
NN |
denotes |
KO |
T3428 |
515-516 |
HYPH |
denotes |
/ |
T3429 |
532-549 |
JJ |
denotes |
indistinguishable |
T3430 |
549-551 |
, |
denotes |
, |
T3431 |
551-557 |
NN |
denotes |
XpdTTD |
T3432 |
565-572 |
NNS |
denotes |
effects |
T3433 |
558-564 |
NN |
denotes |
dosage |
T3434 |
573-577 |
VBD |
denotes |
were |
T3435 |
587-589 |
IN |
denotes |
in |
T3436 |
590-592 |
NN |
denotes |
UV |
T3437 |
593-601 |
NN |
denotes |
survival |
T3438 |
601-603 |
, |
denotes |
, |
T3439 |
603-605 |
NN |
denotes |
UV |
T3440 |
606-609 |
NN |
denotes |
UDS |
T3441 |
605-606 |
HYPH |
denotes |
- |
T3442 |
609-611 |
, |
denotes |
, |
T3443 |
611-614 |
CC |
denotes |
and |
T3444 |
615-617 |
NN |
denotes |
UV |
T3445 |
618-621 |
NN |
denotes |
RRS |
T3446 |
617-618 |
HYPH |
denotes |
- |
T3447 |
621-623 |
, |
denotes |
, |
T3448 |
623-633 |
VBG |
denotes |
indicating |
T3449 |
634-638 |
IN |
denotes |
that |
T3450 |
705-714 |
VB |
denotes |
correlate |
T3451 |
639-647 |
JJ |
denotes |
cellular |
T3452 |
648-658 |
NNS |
denotes |
parameters |
T3453 |
659-661 |
IN |
denotes |
as |
T3454 |
662-670 |
VBN |
denotes |
measured |
T3455 |
671-673 |
IN |
denotes |
in |
T3456 |
674-685 |
NNS |
denotes |
fibroblasts |
T3457 |
686-690 |
RB |
denotes |
here |
T3458 |
691-693 |
VBP |
denotes |
do |
T3459 |
694-697 |
RB |
denotes |
not |
T3460 |
698-704 |
RB |
denotes |
always |
T3461 |
715-719 |
IN |
denotes |
with |
T3462 |
720-723 |
DT |
denotes |
the |
T3463 |
724-733 |
NN |
denotes |
phenotype |
T3464 |
734-736 |
IN |
denotes |
at |
T3465 |
737-740 |
DT |
denotes |
the |
T3466 |
741-746 |
NN |
denotes |
level |
T3467 |
747-749 |
IN |
denotes |
of |
T3468 |
750-753 |
DT |
denotes |
the |
T3469 |
761-769 |
NN |
denotes |
organism |
T3470 |
754-760 |
JJ |
denotes |
intact |
T3471 |
769-770 |
. |
denotes |
. |
T3472 |
770-893 |
sentence |
denotes |
XpdTTD/KO hemizygous cells were thus used as the baseline on which to compare the activity of compound heterozygous cells. |
T3473 |
771-777 |
NN |
denotes |
XpdTTD |
T3474 |
778-780 |
NN |
denotes |
KO |
T3475 |
777-778 |
HYPH |
denotes |
/ |
T3476 |
792-797 |
NNS |
denotes |
cells |
T3477 |
781-791 |
JJ |
denotes |
hemizygous |
T3478 |
808-812 |
VBN |
denotes |
used |
T3479 |
798-802 |
VBD |
denotes |
were |
T3480 |
803-807 |
RB |
denotes |
thus |
T3481 |
813-815 |
IN |
denotes |
as |
T3482 |
816-819 |
DT |
denotes |
the |
T3483 |
820-828 |
NN |
denotes |
baseline |
T3484 |
829-831 |
IN |
denotes |
on |
T3485 |
841-848 |
VB |
denotes |
compare |
T3486 |
832-837 |
WDT |
denotes |
which |
T3487 |
838-840 |
TO |
denotes |
to |
T3488 |
849-852 |
DT |
denotes |
the |
T3489 |
853-861 |
NN |
denotes |
activity |
T3490 |
862-864 |
IN |
denotes |
of |
T3491 |
865-873 |
NN |
denotes |
compound |
T3492 |
887-892 |
NNS |
denotes |
cells |
T3493 |
874-886 |
JJ |
denotes |
heterozygous |
T3494 |
892-893 |
. |
denotes |
. |
T3495 |
893-1100 |
sentence |
denotes |
Relative to XpdTTD/KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd†XPCS allele in XpdTTD/†XPCS compound heterozygous cells and to a lesser degree by the Xpd†XP allele (Figure 4A). |
T3496 |
894-902 |
JJ |
denotes |
Relative |
T3497 |
950-958 |
VBN |
denotes |
improved |
T3498 |
903-905 |
IN |
denotes |
to |
T3499 |
906-912 |
NN |
denotes |
XpdTTD |
T3500 |
913-915 |
NN |
denotes |
KO |
T3501 |
912-913 |
HYPH |
denotes |
/ |
T3502 |
927-932 |
NNS |
denotes |
cells |
T3503 |
916-926 |
NN |
denotes |
hemizygote |
T3504 |
932-934 |
, |
denotes |
, |
T3505 |
934-936 |
NN |
denotes |
UV |
T3506 |
937-945 |
NN |
denotes |
survival |
T3507 |
946-949 |
VBD |
denotes |
was |
T3508 |
959-961 |
IN |
denotes |
by |
T3509 |
962-965 |
DT |
denotes |
the |
T3510 |
993-999 |
NN |
denotes |
allele |
T3511 |
966-976 |
JJ |
denotes |
homozygous |
T3512 |
977-983 |
JJ |
denotes |
lethal |
T3513 |
984-992 |
NN |
denotes |
Xpd†XPCS |
T3514 |
1000-1002 |
IN |
denotes |
in |
T3515 |
1003-1009 |
NN |
denotes |
XpdTTD |
T3516 |
1010-1015 |
NN |
denotes |
†XPCS |
T3517 |
1009-1010 |
HYPH |
denotes |
/ |
T3518 |
1038-1043 |
NNS |
denotes |
cells |
T3519 |
1016-1024 |
NN |
denotes |
compound |
T3520 |
1025-1037 |
JJ |
denotes |
heterozygous |
T3521 |
1044-1047 |
CC |
denotes |
and |
T3522 |
1048-1050 |
IN |
denotes |
to |
T3523 |
1067-1069 |
IN |
denotes |
by |
T3524 |
1051-1052 |
DT |
denotes |
a |
T3525 |
1060-1066 |
NN |
denotes |
degree |
T3526 |
1053-1059 |
JJR |
denotes |
lesser |
T3527 |
1070-1073 |
DT |
denotes |
the |
T3528 |
1081-1087 |
NN |
denotes |
allele |
T3529 |
1074-1080 |
NN |
denotes |
Xpd†XP |
T3530 |
1088-1089 |
-LRB- |
denotes |
( |
T3531 |
1096-1098 |
NN |
denotes |
4A |
T3532 |
1089-1095 |
NN |
denotes |
Figure |
T3533 |
1098-1099 |
-RRB- |
denotes |
) |
T3534 |
1099-1100 |
. |
denotes |
. |
T3535 |
1100-1240 |
sentence |
denotes |
Because of embryonic and cellular lethality, we were unable to test UV survival associated exclusively with the Xpd†XPCS or Xpd†XP alleles. |
T3536 |
1101-1108 |
IN |
denotes |
Because |
T3537 |
1149-1153 |
VBD |
denotes |
were |
T3538 |
1109-1111 |
IN |
denotes |
of |
T3539 |
1112-1121 |
JJ |
denotes |
embryonic |
T3540 |
1135-1144 |
NN |
denotes |
lethality |
T3541 |
1122-1125 |
CC |
denotes |
and |
T3542 |
1126-1134 |
JJ |
denotes |
cellular |
T3543 |
1144-1146 |
, |
denotes |
, |
T3544 |
1146-1148 |
PRP |
denotes |
we |
T3545 |
1154-1160 |
JJ |
denotes |
unable |
T3546 |
1161-1163 |
TO |
denotes |
to |
T3547 |
1164-1168 |
VB |
denotes |
test |
T3548 |
1169-1171 |
NN |
denotes |
UV |
T3549 |
1172-1180 |
NN |
denotes |
survival |
T3550 |
1181-1191 |
VBN |
denotes |
associated |
T3551 |
1192-1203 |
RB |
denotes |
exclusively |
T3552 |
1204-1208 |
IN |
denotes |
with |
T3553 |
1209-1212 |
DT |
denotes |
the |
T3554 |
1232-1239 |
NNS |
denotes |
alleles |
T3555 |
1213-1221 |
NN |
denotes |
Xpd†XPCS |
T3556 |
1222-1224 |
CC |
denotes |
or |
T3557 |
1225-1231 |
NN |
denotes |
Xpd†XP |
T3558 |
1239-1240 |
. |
denotes |
. |
T3559 |
1240-1482 |
sentence |
denotes |
However, homozygous XPDXP (XPDR683W) and hemizygous XPDXPCS (XPDG602D) human cells are known to be highly sensitive to UV [19,25], as are cells from a homozygous viable XpdXPCS/XPCS (XPDG602D/G602D) mouse model (Figure 4A, dotted line) [23]. |
T3560 |
1241-1248 |
RB |
denotes |
However |
T3561 |
1328-1333 |
VBN |
denotes |
known |
T3562 |
1248-1250 |
, |
denotes |
, |
T3563 |
1250-1260 |
JJ |
denotes |
homozygous |
T3564 |
1261-1266 |
NN |
denotes |
XPDXP |
T3565 |
1318-1323 |
NNS |
denotes |
cells |
T3566 |
1267-1268 |
-LRB- |
denotes |
( |
T3567 |
1268-1276 |
NN |
denotes |
XPDR683W |
T3568 |
1276-1277 |
-RRB- |
denotes |
) |
T3569 |
1278-1281 |
CC |
denotes |
and |
T3570 |
1282-1292 |
JJ |
denotes |
hemizygous |
T3571 |
1293-1300 |
NN |
denotes |
XPDXPCS |
T3572 |
1301-1302 |
-LRB- |
denotes |
( |
T3573 |
1302-1310 |
NN |
denotes |
XPDG602D |
T3574 |
1310-1311 |
-RRB- |
denotes |
) |
T3575 |
1312-1317 |
JJ |
denotes |
human |
T3576 |
1324-1327 |
VBP |
denotes |
are |
T3577 |
1334-1336 |
TO |
denotes |
to |
T3578 |
1337-1339 |
VB |
denotes |
be |
T3579 |
1340-1346 |
RB |
denotes |
highly |
T3580 |
1347-1356 |
JJ |
denotes |
sensitive |
T3581 |
1357-1359 |
IN |
denotes |
to |
T3582 |
1360-1362 |
NN |
denotes |
UV |
T3583 |
1363-1364 |
-LRB- |
denotes |
[ |
T3584 |
1367-1369 |
CD |
denotes |
25 |
T3585 |
1364-1366 |
CD |
denotes |
19 |
T3586 |
1366-1367 |
, |
denotes |
, |
T3587 |
1369-1370 |
-RRB- |
denotes |
] |
T3588 |
1370-1372 |
, |
denotes |
, |
T3589 |
1372-1374 |
IN |
denotes |
as |
T3590 |
1375-1378 |
VBP |
denotes |
are |
T3591 |
1379-1384 |
NNS |
denotes |
cells |
T3592 |
1385-1389 |
IN |
denotes |
from |
T3593 |
1390-1391 |
DT |
denotes |
a |
T3594 |
1446-1451 |
NN |
denotes |
model |
T3595 |
1392-1402 |
JJ |
denotes |
homozygous |
T3596 |
1403-1409 |
JJ |
denotes |
viable |
T3597 |
1410-1417 |
NN |
denotes |
XpdXPCS |
T3598 |
1418-1422 |
NN |
denotes |
XPCS |
T3599 |
1417-1418 |
HYPH |
denotes |
/ |
T3600 |
1423-1424 |
-LRB- |
denotes |
( |
T3601 |
1433-1438 |
NN |
denotes |
G602D |
T3602 |
1424-1432 |
NN |
denotes |
XPDG602D |
T3603 |
1432-1433 |
HYPH |
denotes |
/ |
T3604 |
1438-1439 |
-RRB- |
denotes |
) |
T3605 |
1440-1445 |
NN |
denotes |
mouse |
T3606 |
1452-1453 |
-LRB- |
denotes |
( |
T3607 |
1460-1462 |
NN |
denotes |
4A |
T3608 |
1453-1459 |
NN |
denotes |
Figure |
T3609 |
1462-1464 |
, |
denotes |
, |
T3610 |
1464-1470 |
VBN |
denotes |
dotted |
T3611 |
1471-1475 |
NN |
denotes |
line |
T3612 |
1475-1476 |
-RRB- |
denotes |
) |
T3613 |
1477-1478 |
-LRB- |
denotes |
[ |
T3614 |
1478-1480 |
CD |
denotes |
23 |
T3615 |
1480-1481 |
-RRB- |
denotes |
] |
T3616 |
1481-1482 |
. |
denotes |
. |
T3617 |
1482-1643 |
sentence |
denotes |
Thus, the survival of XpdTTD/†XPCS (and XpdTTD/†XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2). |
T3618 |
1483-1487 |
RB |
denotes |
Thus |
T3619 |
1548-1558 |
VBZ |
denotes |
represents |
T3620 |
1487-1489 |
, |
denotes |
, |
T3621 |
1489-1492 |
DT |
denotes |
the |
T3622 |
1493-1501 |
NN |
denotes |
survival |
T3623 |
1502-1504 |
IN |
denotes |
of |
T3624 |
1505-1511 |
NN |
denotes |
XpdTTD |
T3625 |
1512-1517 |
NN |
denotes |
†XPCS |
T3626 |
1511-1512 |
HYPH |
denotes |
/ |
T3627 |
1535-1540 |
NNS |
denotes |
cells |
T3628 |
1518-1519 |
-LRB- |
denotes |
( |
T3629 |
1519-1522 |
CC |
denotes |
and |
T3630 |
1523-1529 |
NN |
denotes |
XpdTTD |
T3631 |
1530-1533 |
NN |
denotes |
†XP |
T3632 |
1529-1530 |
HYPH |
denotes |
/ |
T3633 |
1533-1534 |
-RRB- |
denotes |
) |
T3634 |
1541-1547 |
RB |
denotes |
likely |
T3635 |
1559-1560 |
DT |
denotes |
a |
T3636 |
1561-1566 |
NN |
denotes |
level |
T3637 |
1567-1569 |
IN |
denotes |
of |
T3638 |
1570-1572 |
NN |
denotes |
UV |
T3639 |
1573-1583 |
NN |
denotes |
resistance |
T3640 |
1584-1588 |
WDT |
denotes |
that |
T3641 |
1615-1621 |
VB |
denotes |
impart |
T3642 |
1589-1596 |
CC |
denotes |
neither |
T3643 |
1604-1610 |
NN |
denotes |
allele |
T3644 |
1597-1603 |
JJ |
denotes |
mutant |
T3645 |
1611-1614 |
MD |
denotes |
can |
T3646 |
1622-1624 |
IN |
denotes |
on |
T3647 |
1625-1628 |
PRP$ |
denotes |
its |
T3648 |
1629-1632 |
NN |
denotes |
own |
T3649 |
1633-1634 |
-LRB- |
denotes |
( |
T3650 |
1634-1639 |
NN |
denotes |
Table |
T3651 |
1640-1641 |
CD |
denotes |
2 |
T3652 |
1641-1642 |
-RRB- |
denotes |
) |
T3653 |
1642-1643 |
. |
denotes |
. |
T3654 |
1643-1801 |
sentence |
denotes |
Significant effects of compound heterozygosity on NER subpathways relative to XpdTTD/KO cells were observed in XpdTTD/†XP cells but only for UV-UDS activity. |
T3655 |
1644-1655 |
JJ |
denotes |
Significant |
T3656 |
1656-1663 |
NNS |
denotes |
effects |
T3657 |
1743-1751 |
VBN |
denotes |
observed |
T3658 |
1664-1666 |
IN |
denotes |
of |
T3659 |
1667-1675 |
NN |
denotes |
compound |
T3660 |
1676-1690 |
NN |
denotes |
heterozygosity |
T3661 |
1691-1693 |
IN |
denotes |
on |
T3662 |
1694-1697 |
NN |
denotes |
NER |
T3663 |
1698-1709 |
NNS |
denotes |
subpathways |
T3664 |
1710-1718 |
JJ |
denotes |
relative |
T3665 |
1719-1721 |
IN |
denotes |
to |
T3666 |
1722-1728 |
NN |
denotes |
XpdTTD |
T3667 |
1729-1731 |
NN |
denotes |
KO |
T3668 |
1728-1729 |
HYPH |
denotes |
/ |
T3669 |
1732-1737 |
NNS |
denotes |
cells |
T3670 |
1738-1742 |
VBD |
denotes |
were |
T3671 |
1752-1754 |
IN |
denotes |
in |
T3672 |
1755-1761 |
NN |
denotes |
XpdTTD |
T3673 |
1762-1765 |
NN |
denotes |
†XP |
T3674 |
1761-1762 |
HYPH |
denotes |
/ |
T3675 |
1766-1771 |
NNS |
denotes |
cells |
T3676 |
1772-1775 |
CC |
denotes |
but |
T3677 |
1776-1780 |
RB |
denotes |
only |
T3678 |
1781-1784 |
IN |
denotes |
for |
T3679 |
1785-1787 |
NN |
denotes |
UV |
T3680 |
1788-1791 |
NN |
denotes |
UDS |
T3681 |
1787-1788 |
HYPH |
denotes |
- |
T3682 |
1792-1800 |
NN |
denotes |
activity |
T3683 |
1800-1801 |
. |
denotes |
. |
T3684 |
1801-2050 |
sentence |
denotes |
Finally, none of the mutant TFIIH combinations (carrying alterations associated with TTD [XPDR722W], XPCS [XPDG602D], or XP [XPDR683W]) exhibited synergism in an in vitro NER reaction reconstituted with different mutant TFIIH complexes (Figure 4D). |
T3685 |
1802-1809 |
RB |
denotes |
Finally |
T3686 |
1938-1947 |
VBD |
denotes |
exhibited |
T3687 |
1809-1811 |
, |
denotes |
, |
T3688 |
1811-1815 |
NN |
denotes |
none |
T3689 |
1816-1818 |
IN |
denotes |
of |
T3690 |
1819-1822 |
DT |
denotes |
the |
T3691 |
1836-1848 |
NNS |
denotes |
combinations |
T3692 |
1823-1829 |
JJ |
denotes |
mutant |
T3693 |
1830-1835 |
NN |
denotes |
TFIIH |
T3694 |
1849-1850 |
-LRB- |
denotes |
( |
T3695 |
1850-1858 |
VBG |
denotes |
carrying |
T3696 |
1859-1870 |
NNS |
denotes |
alterations |
T3697 |
1871-1881 |
VBN |
denotes |
associated |
T3698 |
1882-1886 |
IN |
denotes |
with |
T3699 |
1887-1890 |
NN |
denotes |
TTD |
T3700 |
1891-1892 |
-LRB- |
denotes |
[ |
T3701 |
1892-1900 |
NN |
denotes |
XPDR722W |
T3702 |
1900-1901 |
-RRB- |
denotes |
] |
T3703 |
1901-1903 |
, |
denotes |
, |
T3704 |
1903-1907 |
NN |
denotes |
XPCS |
T3705 |
1908-1909 |
-LRB- |
denotes |
[ |
T3706 |
1909-1917 |
NN |
denotes |
XPDG602D |
T3707 |
1917-1918 |
-RRB- |
denotes |
] |
T3708 |
1918-1920 |
, |
denotes |
, |
T3709 |
1920-1922 |
CC |
denotes |
or |
T3710 |
1923-1925 |
NN |
denotes |
XP |
T3711 |
1926-1927 |
-LRB- |
denotes |
[ |
T3712 |
1927-1935 |
NN |
denotes |
XPDR683W |
T3713 |
1935-1936 |
-RRB- |
denotes |
] |
T3714 |
1936-1937 |
-RRB- |
denotes |
) |
T3715 |
1948-1957 |
NN |
denotes |
synergism |
T3716 |
1958-1960 |
IN |
denotes |
in |
T3717 |
1961-1963 |
DT |
denotes |
an |
T3718 |
1977-1985 |
NN |
denotes |
reaction |
T3719 |
1964-1966 |
FW |
denotes |
in |
T3720 |
1967-1972 |
FW |
denotes |
vitro |
T3721 |
1973-1976 |
NN |
denotes |
NER |
T3722 |
1986-1999 |
VBN |
denotes |
reconstituted |
T3723 |
2000-2004 |
IN |
denotes |
with |
T3724 |
2005-2014 |
JJ |
denotes |
different |
T3725 |
2028-2037 |
NNS |
denotes |
complexes |
T3726 |
2015-2021 |
JJ |
denotes |
mutant |
T3727 |
2022-2027 |
NN |
denotes |
TFIIH |
T3728 |
2038-2039 |
-LRB- |
denotes |
( |
T3729 |
2046-2048 |
NN |
denotes |
4D |
T3730 |
2039-2045 |
NN |
denotes |
Figure |
T3731 |
2048-2049 |
-RRB- |
denotes |
) |
T3732 |
2049-2050 |
. |
denotes |
. |
T3733 |
2050-2285 |
sentence |
denotes |
Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV-related repair characteristics and TTD progeroid phenotypes in animal models. |
T3734 |
2051-2056 |
VBN |
denotes |
Taken |
T3735 |
2078-2081 |
VBP |
denotes |
are |
T3736 |
2057-2065 |
RB |
denotes |
together |
T3737 |
2065-2067 |
, |
denotes |
, |
T3738 |
2067-2072 |
DT |
denotes |
these |
T3739 |
2073-2077 |
NNS |
denotes |
data |
T3740 |
2082-2092 |
JJ |
denotes |
consistent |
T3741 |
2093-2097 |
IN |
denotes |
with |
T3742 |
2098-2110 |
JJ |
denotes |
interallelic |
T3743 |
2111-2126 |
NN |
denotes |
complementation |
T3744 |
2127-2129 |
IN |
denotes |
of |
T3745 |
2130-2132 |
NN |
denotes |
UV |
T3746 |
2133-2144 |
NN |
denotes |
sensitivity |
T3747 |
2145-2147 |
IN |
denotes |
in |
T3748 |
2148-2153 |
NNS |
denotes |
cells |
T3749 |
2154-2157 |
CC |
denotes |
but |
T3750 |
2158-2168 |
VBP |
denotes |
underscore |
T3751 |
2169-2172 |
DT |
denotes |
the |
T3752 |
2173-2177 |
NN |
denotes |
lack |
T3753 |
2178-2180 |
IN |
denotes |
of |
T3754 |
2181-2184 |
DT |
denotes |
any |
T3755 |
2185-2196 |
NN |
denotes |
correlation |
T3756 |
2197-2204 |
IN |
denotes |
between |
T3757 |
2205-2207 |
NN |
denotes |
UV |
T3758 |
2208-2215 |
VBN |
denotes |
related |
T3759 |
2207-2208 |
HYPH |
denotes |
- |
T3760 |
2223-2238 |
NNS |
denotes |
characteristics |
T3761 |
2216-2222 |
NN |
denotes |
repair |
T3762 |
2239-2242 |
CC |
denotes |
and |
T3763 |
2243-2246 |
NN |
denotes |
TTD |
T3764 |
2257-2267 |
NNS |
denotes |
phenotypes |
T3765 |
2247-2256 |
NN |
denotes |
progeroid |
T3766 |
2268-2270 |
IN |
denotes |
in |
T3767 |
2271-2277 |
NN |
denotes |
animal |
T3768 |
2278-2284 |
NNS |
denotes |
models |
T3769 |
2284-2285 |
. |
denotes |
. |
R2087 |
T3318 |
T3319 |
nsubj |
We,turned |
R2088 |
T3320 |
T3319 |
advmod |
next,turned |
R2089 |
T3321 |
T3319 |
prep |
to,turned |
R2090 |
T3322 |
T3323 |
npadvmod |
UV,based |
R2091 |
T3323 |
T3325 |
amod |
based,assays |
R2092 |
T3324 |
T3323 |
punct |
-,based |
R2093 |
T3325 |
T3321 |
pobj |
assays,to |
R2094 |
T3326 |
T3325 |
amod |
cellular,assays |
R2095 |
T3327 |
T3325 |
prep |
including,assays |
R2096 |
T3328 |
T3329 |
amod |
unscheduled,synthesis |
R2097 |
T3329 |
T3327 |
pobj |
synthesis,including |
R2098 |
T3330 |
T3329 |
compound |
DNA,synthesis |
R2099 |
T3331 |
T3329 |
prep |
after,synthesis |
R2100 |
T3332 |
T3333 |
compound |
UV,irradiation |
R2101 |
T3333 |
T3331 |
pobj |
irradiation,after |
R2102 |
T3334 |
T3335 |
punct |
(,UDS |
R2103 |
T3335 |
T3329 |
parataxis |
UDS,synthesis |
R2104 |
T3336 |
T3335 |
compound |
UV,UDS |
R2105 |
T3337 |
T3335 |
punct |
-,UDS |
R2106 |
T3338 |
T3335 |
punct |
),UDS |
R2107 |
T3339 |
T3329 |
punct |
", ",synthesis |
R2108 |
T3340 |
T3329 |
conj |
recovery,synthesis |
R2109 |
T3341 |
T3340 |
prep |
of,recovery |
R2110 |
T3342 |
T3343 |
compound |
RNA,synthesis |
R2111 |
T3343 |
T3341 |
pobj |
synthesis,of |
R2112 |
T3344 |
T3340 |
prep |
after,recovery |
R2113 |
T3345 |
T3346 |
compound |
UV,irradiation |
R2114 |
T3346 |
T3344 |
pobj |
irradiation,after |
R2115 |
T3347 |
T3348 |
punct |
(,RRS |
R2116 |
T3348 |
T3340 |
parataxis |
RRS,recovery |
R2117 |
T3349 |
T3348 |
compound |
UV,RRS |
R2118 |
T3350 |
T3348 |
punct |
-,RRS |
R2119 |
T3351 |
T3348 |
punct |
),RRS |
R2120 |
T3352 |
T3340 |
punct |
", ",recovery |
R2121 |
T3353 |
T3340 |
cc |
and,recovery |
R2122 |
T3354 |
T3355 |
compound |
UV,survival |
R2123 |
T3355 |
T3340 |
conj |
survival,recovery |
R2124 |
T3356 |
T3329 |
punct |
", ",synthesis |
R2125 |
T3357 |
T3358 |
dep |
which,report |
R2126 |
T3358 |
T3329 |
relcl |
report,synthesis |
R2127 |
T3359 |
T3358 |
prep |
on,report |
R2128 |
T3360 |
T3361 |
det |
the,subpathways |
R2129 |
T3361 |
T3359 |
pobj |
subpathways,on |
R2130 |
T3362 |
T3361 |
compound |
NER,subpathways |
R2131 |
T3363 |
T3364 |
punct |
(,NER |
R2132 |
T3364 |
T3361 |
parataxis |
NER,subpathways |
R2133 |
T3365 |
T3364 |
amod |
global,NER |
R2134 |
T3366 |
T3364 |
compound |
genome,NER |
R2135 |
T3367 |
T3364 |
cc |
and,NER |
R2136 |
T3368 |
T3369 |
npadvmod |
transcription,coupled |
R2137 |
T3369 |
T3371 |
amod |
coupled,NER |
R2138 |
T3370 |
T3369 |
punct |
-,coupled |
R2139 |
T3371 |
T3364 |
conj |
NER,NER |
R2140 |
T3372 |
T3364 |
punct |
),NER |
R2141 |
T3373 |
T3361 |
cc |
and,subpathways |
R2142 |
T3374 |
T3375 |
amod |
total,NER |
R2143 |
T3375 |
T3361 |
conj |
NER,subpathways |
R2144 |
T3376 |
T3358 |
punct |
", ",report |
R2145 |
T3377 |
T3358 |
advmod |
respectively,report |
R2146 |
T3378 |
T3319 |
punct |
.,turned |
R2147 |
T3380 |
T3381 |
prep |
In,improved |
R2148 |
T3382 |
T3380 |
pobj |
none,In |
R2149 |
T3383 |
T3382 |
prep |
of,none |
R2150 |
T3384 |
T3385 |
det |
these,assays |
R2151 |
T3385 |
T3383 |
pobj |
assays,of |
R2152 |
T3386 |
T3381 |
auxpass |
was,improved |
R2153 |
T3387 |
T3388 |
det |
the,response |
R2154 |
T3388 |
T3381 |
nsubjpass |
response,improved |
R2155 |
T3389 |
T3388 |
prep |
to,response |
R2156 |
T3390 |
T3389 |
pobj |
UV,to |
R2157 |
T3391 |
T3381 |
prep |
in,improved |
R2158 |
T3392 |
T3393 |
compound |
compound,heterozygotes |
R2159 |
T3393 |
T3391 |
pobj |
heterozygotes,in |
R2160 |
T3394 |
T3381 |
advcl |
relative,improved |
R2161 |
T3395 |
T3394 |
prep |
to,relative |
R2162 |
T3396 |
T3397 |
compound |
TTD,homozygotes |
R2163 |
T3397 |
T3395 |
pobj |
homozygotes,to |
R2164 |
T3398 |
T3399 |
punct |
(,4A |
R2165 |
T3399 |
T3381 |
parataxis |
4A,improved |
R2166 |
T3400 |
T3399 |
compound |
Figure,4A |
R2167 |
T3401 |
T3402 |
punct |
–,4C |
R2168 |
T3402 |
T3399 |
prep |
4C,4A |
R2169 |
T3403 |
T3399 |
punct |
),4A |
R2170 |
T3404 |
T3381 |
punct |
.,improved |
R2171 |
T3406 |
T3407 |
advmod |
However,observed |
R2172 |
T3408 |
T3407 |
punct |
", ",observed |
R2173 |
T3409 |
T3407 |
prep |
unlike,observed |
R2174 |
T3410 |
T3411 |
det |
the,phenotypes |
R2175 |
T3411 |
T3409 |
pobj |
phenotypes,unlike |
R2176 |
T3412 |
T3413 |
advmod |
in,vivo |
R2177 |
T3413 |
T3411 |
amod |
vivo,phenotypes |
R2178 |
T3414 |
T3411 |
compound |
TTD,phenotypes |
R2179 |
T3415 |
T3411 |
acl |
described,phenotypes |
R2180 |
T3416 |
T3415 |
advmod |
above,described |
R2181 |
T3417 |
T3411 |
punct |
", ",phenotypes |
R2182 |
T3418 |
T3419 |
prep |
in,were |
R2183 |
T3419 |
T3411 |
relcl |
were,phenotypes |
R2184 |
T3420 |
T3418 |
pobj |
which,in |
R2185 |
T3421 |
T3422 |
nmod |
XpdTTD,TTD |
R2186 |
T3422 |
T3424 |
nmod |
TTD,animals |
R2187 |
T3423 |
T3422 |
punct |
/,TTD |
R2188 |
T3424 |
T3419 |
nsubj |
animals,were |
R2189 |
T3425 |
T3422 |
cc |
and,TTD |
R2190 |
T3426 |
T3427 |
compound |
XpdTTD,KO |
R2191 |
T3427 |
T3422 |
conj |
KO,TTD |
R2192 |
T3428 |
T3427 |
punct |
/,KO |
R2193 |
T3429 |
T3419 |
acomp |
indistinguishable,were |
R2194 |
T3430 |
T3407 |
punct |
", ",observed |
R2195 |
T3431 |
T3432 |
compound |
XpdTTD,effects |
R2196 |
T3432 |
T3407 |
nsubjpass |
effects,observed |
R2197 |
T3433 |
T3432 |
compound |
dosage,effects |
R2198 |
T3434 |
T3407 |
auxpass |
were,observed |
R2199 |
T3435 |
T3407 |
prep |
in,observed |
R2200 |
T3436 |
T3437 |
compound |
UV,survival |
R2201 |
T3437 |
T3435 |
pobj |
survival,in |
R2202 |
T3438 |
T3437 |
punct |
", ",survival |
R2203 |
T3439 |
T3440 |
compound |
UV,UDS |
R2204 |
T3440 |
T3437 |
conj |
UDS,survival |
R2205 |
T3441 |
T3440 |
punct |
-,UDS |
R2206 |
T3442 |
T3440 |
punct |
", ",UDS |
R2207 |
T3443 |
T3440 |
cc |
and,UDS |
R2208 |
T3444 |
T3445 |
compound |
UV,RRS |
R2209 |
T3445 |
T3440 |
conj |
RRS,UDS |
R2210 |
T3446 |
T3445 |
punct |
-,RRS |
R2211 |
T3447 |
T3407 |
punct |
", ",observed |
R2212 |
T3448 |
T3407 |
advcl |
indicating,observed |
R2213 |
T3449 |
T3450 |
mark |
that,correlate |
R2214 |
T3450 |
T3448 |
ccomp |
correlate,indicating |
R2215 |
T3451 |
T3452 |
amod |
cellular,parameters |
R2216 |
T3452 |
T3450 |
nsubj |
parameters,correlate |
R2217 |
T3453 |
T3454 |
mark |
as,measured |
R2218 |
T3454 |
T3452 |
advcl |
measured,parameters |
R2219 |
T3455 |
T3454 |
prep |
in,measured |
R2220 |
T3456 |
T3455 |
pobj |
fibroblasts,in |
R2221 |
T3457 |
T3454 |
advmod |
here,measured |
R2222 |
T3458 |
T3450 |
aux |
do,correlate |
R2223 |
T3459 |
T3450 |
neg |
not,correlate |
R2224 |
T3460 |
T3450 |
advmod |
always,correlate |
R2225 |
T3461 |
T3450 |
prep |
with,correlate |
R2226 |
T3462 |
T3463 |
det |
the,phenotype |
R2227 |
T3463 |
T3461 |
pobj |
phenotype,with |
R2228 |
T3464 |
T3450 |
prep |
at,correlate |
R2229 |
T3465 |
T3466 |
det |
the,level |
R2230 |
T3466 |
T3464 |
pobj |
level,at |
R2231 |
T3467 |
T3466 |
prep |
of,level |
R2232 |
T3468 |
T3469 |
det |
the,organism |
R2233 |
T3469 |
T3467 |
pobj |
organism,of |
R2234 |
T3470 |
T3469 |
amod |
intact,organism |
R2235 |
T3471 |
T3407 |
punct |
.,observed |
R2236 |
T3473 |
T3474 |
nmod |
XpdTTD,KO |
R2237 |
T3474 |
T3476 |
nmod |
KO,cells |
R2238 |
T3475 |
T3474 |
punct |
/,KO |
R2239 |
T3476 |
T3478 |
nsubjpass |
cells,used |
R2240 |
T3477 |
T3476 |
amod |
hemizygous,cells |
R2241 |
T3479 |
T3478 |
auxpass |
were,used |
R2242 |
T3480 |
T3478 |
advmod |
thus,used |
R2243 |
T3481 |
T3478 |
prep |
as,used |
R2244 |
T3482 |
T3483 |
det |
the,baseline |
R2245 |
T3483 |
T3481 |
pobj |
baseline,as |
R2246 |
T3484 |
T3485 |
prep |
on,compare |
R2247 |
T3485 |
T3483 |
relcl |
compare,baseline |
R2248 |
T3486 |
T3484 |
pobj |
which,on |
R2249 |
T3487 |
T3485 |
aux |
to,compare |
R2250 |
T3488 |
T3489 |
det |
the,activity |
R2251 |
T3489 |
T3485 |
dobj |
activity,compare |
R2252 |
T3490 |
T3489 |
prep |
of,activity |
R2253 |
T3491 |
T3492 |
nmod |
compound,cells |
R2254 |
T3492 |
T3490 |
pobj |
cells,of |
R2255 |
T3493 |
T3492 |
amod |
heterozygous,cells |
R2256 |
T3494 |
T3478 |
punct |
.,used |
R2257 |
T3496 |
T3497 |
advcl |
Relative,improved |
R2258 |
T3498 |
T3496 |
prep |
to,Relative |
R2259 |
T3499 |
T3500 |
compound |
XpdTTD,KO |
R2260 |
T3500 |
T3502 |
compound |
KO,cells |
R2261 |
T3501 |
T3500 |
punct |
/,KO |
R2262 |
T3502 |
T3498 |
pobj |
cells,to |
R2263 |
T3503 |
T3502 |
compound |
hemizygote,cells |
R2264 |
T3504 |
T3497 |
punct |
", ",improved |
R2265 |
T3505 |
T3506 |
compound |
UV,survival |
R2266 |
T3506 |
T3497 |
nsubjpass |
survival,improved |
R2267 |
T3507 |
T3497 |
auxpass |
was,improved |
R2268 |
T3508 |
T3497 |
prep |
by,improved |
R2269 |
T3509 |
T3510 |
det |
the,allele |
R2270 |
T3510 |
T3508 |
pobj |
allele,by |
R2271 |
T3511 |
T3510 |
amod |
homozygous,allele |
R2272 |
T3512 |
T3510 |
amod |
lethal,allele |
R2273 |
T3513 |
T3510 |
compound |
Xpd†XPCS,allele |
R2274 |
T3514 |
T3510 |
prep |
in,allele |
R2275 |
T3515 |
T3516 |
nmod |
XpdTTD,†XPCS |
R2276 |
T3516 |
T3518 |
nmod |
†XPCS,cells |
R2277 |
T3517 |
T3516 |
punct |
/,†XPCS |
R2278 |
T3518 |
T3514 |
pobj |
cells,in |
R2279 |
T3519 |
T3518 |
nmod |
compound,cells |
R2280 |
T3520 |
T3518 |
amod |
heterozygous,cells |
R2281 |
T3521 |
T3508 |
cc |
and,by |
R2282 |
T3522 |
T3523 |
prep |
to,by |
R2283 |
T3523 |
T3508 |
conj |
by,by |
R2284 |
T3524 |
T3525 |
det |
a,degree |
R2285 |
T3525 |
T3522 |
pobj |
degree,to |
R2286 |
T3526 |
T3525 |
amod |
lesser,degree |
R2287 |
T3527 |
T3528 |
det |
the,allele |
R2288 |
T3528 |
T3523 |
pobj |
allele,by |
R2289 |
T3529 |
T3528 |
compound |
Xpd†XP,allele |
R2290 |
T3530 |
T3531 |
punct |
(,4A |
R2291 |
T3531 |
T3497 |
parataxis |
4A,improved |
R2292 |
T3532 |
T3531 |
compound |
Figure,4A |
R2293 |
T3533 |
T3531 |
punct |
),4A |
R2294 |
T3534 |
T3497 |
punct |
.,improved |
R2295 |
T3536 |
T3537 |
prep |
Because,were |
R2296 |
T3538 |
T3536 |
pcomp |
of,Because |
R2297 |
T3539 |
T3540 |
amod |
embryonic,lethality |
R2298 |
T3540 |
T3536 |
pobj |
lethality,Because |
R2299 |
T3541 |
T3539 |
cc |
and,embryonic |
R2300 |
T3542 |
T3539 |
conj |
cellular,embryonic |
R2301 |
T3543 |
T3537 |
punct |
", ",were |
R2302 |
T3544 |
T3537 |
nsubj |
we,were |
R2303 |
T3545 |
T3537 |
acomp |
unable,were |
R2304 |
T3546 |
T3547 |
aux |
to,test |
R2305 |
T3547 |
T3545 |
xcomp |
test,unable |
R2306 |
T3548 |
T3549 |
compound |
UV,survival |
R2307 |
T3549 |
T3547 |
dobj |
survival,test |
R2308 |
T3550 |
T3549 |
acl |
associated,survival |
R2309 |
T3551 |
T3550 |
advmod |
exclusively,associated |
R2310 |
T3552 |
T3550 |
prep |
with,associated |
R2311 |
T3553 |
T3554 |
det |
the,alleles |
R2312 |
T3554 |
T3552 |
pobj |
alleles,with |
R2313 |
T3555 |
T3554 |
nmod |
Xpd†XPCS,alleles |
R2314 |
T3556 |
T3555 |
cc |
or,Xpd†XPCS |
R2315 |
T3557 |
T3555 |
conj |
Xpd†XP,Xpd†XPCS |
R2316 |
T3558 |
T3537 |
punct |
.,were |
R2317 |
T3560 |
T3561 |
advmod |
However,known |
R2318 |
T3562 |
T3561 |
punct |
", ",known |
R2319 |
T3563 |
T3564 |
amod |
homozygous,XPDXP |
R2320 |
T3564 |
T3565 |
nmod |
XPDXP,cells |
R2321 |
T3565 |
T3561 |
nsubjpass |
cells,known |
R2322 |
T3566 |
T3567 |
punct |
(,XPDR683W |
R2323 |
T3567 |
T3564 |
parataxis |
XPDR683W,XPDXP |
R2324 |
T3568 |
T3567 |
punct |
),XPDR683W |
R2325 |
T3569 |
T3564 |
cc |
and,XPDXP |
R2326 |
T3570 |
T3571 |
amod |
hemizygous,XPDXPCS |
R2327 |
T3571 |
T3564 |
conj |
XPDXPCS,XPDXP |
R2328 |
T3572 |
T3573 |
punct |
(,XPDG602D |
R2329 |
T3573 |
T3571 |
parataxis |
XPDG602D,XPDXPCS |
R2330 |
T3574 |
T3573 |
punct |
),XPDG602D |
R2331 |
T3575 |
T3565 |
amod |
human,cells |
R2332 |
T3576 |
T3561 |
auxpass |
are,known |
R2333 |
T3577 |
T3578 |
aux |
to,be |
R2334 |
T3578 |
T3561 |
xcomp |
be,known |
R2335 |
T3579 |
T3580 |
advmod |
highly,sensitive |
R2336 |
T3580 |
T3578 |
acomp |
sensitive,be |
R2337 |
T3581 |
T3580 |
prep |
to,sensitive |
R2338 |
T3582 |
T3581 |
pobj |
UV,to |
R2339 |
T3583 |
T3584 |
punct |
[,25 |
R2340 |
T3584 |
T3578 |
parataxis |
25,be |
R2341 |
T3585 |
T3584 |
nummod |
19,25 |
R2342 |
T3586 |
T3584 |
punct |
",",25 |
R2343 |
T3587 |
T3584 |
punct |
],25 |
R2344 |
T3588 |
T3561 |
punct |
", ",known |
R2345 |
T3589 |
T3590 |
mark |
as,are |
R2346 |
T3590 |
T3561 |
advcl |
are,known |
R2347 |
T3591 |
T3590 |
nsubj |
cells,are |
R2348 |
T3592 |
T3591 |
prep |
from,cells |
R2349 |
T3593 |
T3594 |
det |
a,model |
R2350 |
T3594 |
T3592 |
pobj |
model,from |
R2351 |
T3595 |
T3594 |
amod |
homozygous,model |
R2352 |
T3596 |
T3594 |
amod |
viable,model |
R2353 |
T3597 |
T3598 |
nmod |
XpdXPCS,XPCS |
R2354 |
T3598 |
T3594 |
nmod |
XPCS,model |
R2355 |
T3599 |
T3598 |
punct |
/,XPCS |
R2356 |
T3600 |
T3601 |
punct |
(,G602D |
R2357 |
T3601 |
T3598 |
parataxis |
G602D,XPCS |
R2358 |
T3602 |
T3601 |
compound |
XPDG602D,G602D |
R2359 |
T3603 |
T3601 |
punct |
/,G602D |
R2360 |
T3604 |
T3601 |
punct |
),G602D |
R2361 |
T3605 |
T3594 |
compound |
mouse,model |
R2362 |
T3606 |
T3607 |
punct |
(,4A |
R2363 |
T3607 |
T3590 |
parataxis |
4A,are |
R2364 |
T3608 |
T3607 |
compound |
Figure,4A |
R2365 |
T3609 |
T3607 |
punct |
", ",4A |
R2366 |
T3610 |
T3611 |
amod |
dotted,line |
R2367 |
T3611 |
T3607 |
appos |
line,4A |
R2368 |
T3612 |
T3607 |
punct |
),4A |
R2369 |
T3613 |
T3614 |
punct |
[,23 |
R2370 |
T3614 |
T3561 |
parataxis |
23,known |
R2371 |
T3615 |
T3614 |
punct |
],23 |
R2372 |
T3616 |
T3561 |
punct |
.,known |
R2373 |
T3618 |
T3619 |
advmod |
Thus,represents |
R2374 |
T3620 |
T3619 |
punct |
", ",represents |
R2375 |
T3621 |
T3622 |
det |
the,survival |
R2376 |
T3622 |
T3619 |
nsubj |
survival,represents |
R2377 |
T3623 |
T3622 |
prep |
of,survival |
R2378 |
T3624 |
T3625 |
nmod |
XpdTTD,†XPCS |
R2379 |
T3625 |
T3627 |
nmod |
†XPCS,cells |
R2380 |
T3626 |
T3625 |
punct |
/,†XPCS |
R2381 |
T3627 |
T3623 |
pobj |
cells,of |
R2382 |
T3628 |
T3625 |
punct |
(,†XPCS |
R2383 |
T3629 |
T3625 |
cc |
and,†XPCS |
R2384 |
T3630 |
T3631 |
compound |
XpdTTD,†XP |
R2385 |
T3631 |
T3625 |
conj |
†XP,†XPCS |
R2386 |
T3632 |
T3631 |
punct |
/,†XP |
R2387 |
T3633 |
T3627 |
punct |
),cells |
R2388 |
T3634 |
T3619 |
advmod |
likely,represents |
R2389 |
T3635 |
T3636 |
det |
a,level |
R2390 |
T3636 |
T3619 |
dobj |
level,represents |
R2391 |
T3637 |
T3636 |
prep |
of,level |
R2392 |
T3638 |
T3639 |
compound |
UV,resistance |
R2393 |
T3639 |
T3637 |
pobj |
resistance,of |
R2394 |
T3640 |
T3641 |
dep |
that,impart |
R2395 |
T3641 |
T3636 |
relcl |
impart,level |
R2396 |
T3642 |
T3643 |
preconj |
neither,allele |
R2397 |
T3643 |
T3641 |
nsubj |
allele,impart |
R2398 |
T3644 |
T3643 |
amod |
mutant,allele |
R2399 |
T3645 |
T3641 |
aux |
can,impart |
R2400 |
T3646 |
T3641 |
prep |
on,impart |
R2401 |
T3647 |
T3648 |
poss |
its,own |
R2402 |
T3648 |
T3646 |
pobj |
own,on |
R2403 |
T3649 |
T3650 |
punct |
(,Table |
R2404 |
T3650 |
T3619 |
parataxis |
Table,represents |
R2405 |
T3651 |
T3650 |
nummod |
2,Table |
R2406 |
T3652 |
T3650 |
punct |
),Table |
R2407 |
T3653 |
T3619 |
punct |
.,represents |
R2408 |
T3655 |
T3656 |
amod |
Significant,effects |
R2409 |
T3656 |
T3657 |
nsubjpass |
effects,observed |
R2410 |
T3658 |
T3656 |
prep |
of,effects |
R2411 |
T3659 |
T3660 |
compound |
compound,heterozygosity |
R2412 |
T3660 |
T3658 |
pobj |
heterozygosity,of |
R2413 |
T3661 |
T3656 |
prep |
on,effects |
R2414 |
T3662 |
T3663 |
compound |
NER,subpathways |
R2415 |
T3663 |
T3661 |
pobj |
subpathways,on |
R2416 |
T3664 |
T3656 |
amod |
relative,effects |
R2417 |
T3665 |
T3664 |
prep |
to,relative |
R2418 |
T3666 |
T3667 |
compound |
XpdTTD,KO |
R2419 |
T3667 |
T3669 |
compound |
KO,cells |
R2420 |
T3668 |
T3667 |
punct |
/,KO |
R2421 |
T3669 |
T3665 |
pobj |
cells,to |
R2422 |
T3670 |
T3657 |
auxpass |
were,observed |
R2423 |
T3671 |
T3657 |
prep |
in,observed |
R2424 |
T3672 |
T3673 |
compound |
XpdTTD,†XP |
R2425 |
T3673 |
T3675 |
compound |
†XP,cells |
R2426 |
T3674 |
T3673 |
punct |
/,†XP |
R2427 |
T3675 |
T3671 |
pobj |
cells,in |
R2428 |
T3676 |
T3671 |
cc |
but,in |
R2429 |
T3677 |
T3678 |
advmod |
only,for |
R2430 |
T3678 |
T3671 |
conj |
for,in |
R2431 |
T3679 |
T3680 |
compound |
UV,UDS |
R2432 |
T3680 |
T3682 |
compound |
UDS,activity |
R2433 |
T3681 |
T3680 |
punct |
-,UDS |
R2434 |
T3682 |
T3678 |
pobj |
activity,for |
R2435 |
T3683 |
T3657 |
punct |
.,observed |
R2436 |
T3685 |
T3686 |
advmod |
Finally,exhibited |
R2437 |
T3687 |
T3686 |
punct |
", ",exhibited |
R2438 |
T3688 |
T3686 |
nsubj |
none,exhibited |
R2441 |
T3691 |
T3689 |
pobj |
combinations,of |
R2442 |
T3692 |
T3691 |
amod |
mutant,combinations |
R2443 |
T3693 |
T3691 |
compound |
TFIIH,combinations |
R2444 |
T3694 |
T3691 |
punct |
(,combinations |
R2445 |
T3695 |
T3691 |
acl |
carrying,combinations |
R2446 |
T3696 |
T3695 |
dobj |
alterations,carrying |
R2447 |
T3697 |
T3696 |
acl |
associated,alterations |
R2448 |
T3698 |
T3697 |
prep |
with,associated |
R2449 |
T3699 |
T3698 |
pobj |
TTD,with |
R2450 |
T3700 |
T3701 |
punct |
[,XPDR722W |
R2451 |
T3701 |
T3699 |
parataxis |
XPDR722W,TTD |
R2452 |
T3702 |
T3701 |
punct |
],XPDR722W |
R2453 |
T3703 |
T3699 |
punct |
", ",TTD |
R2454 |
T3704 |
T3699 |
conj |
XPCS,TTD |
R2455 |
T3705 |
T3706 |
punct |
[,XPDG602D |
R2456 |
T3706 |
T3704 |
parataxis |
XPDG602D,XPCS |
R2457 |
T3707 |
T3706 |
punct |
],XPDG602D |
R2458 |
T3708 |
T3704 |
punct |
", ",XPCS |
R2459 |
T3709 |
T3704 |
cc |
or,XPCS |
R2460 |
T3710 |
T3704 |
conj |
XP,XPCS |
R2461 |
T3711 |
T3712 |
punct |
[,XPDR683W |
R2462 |
T3712 |
T3710 |
parataxis |
XPDR683W,XP |
R2463 |
T3713 |
T3712 |
punct |
],XPDR683W |
R2464 |
T3714 |
T3686 |
punct |
),exhibited |
R2465 |
T3715 |
T3686 |
dobj |
synergism,exhibited |
R2466 |
T3716 |
T3686 |
prep |
in,exhibited |
R2467 |
T3717 |
T3718 |
det |
an,reaction |
R2468 |
T3718 |
T3716 |
pobj |
reaction,in |
R2469 |
T3719 |
T3720 |
advmod |
in,vitro |
R2470 |
T3720 |
T3718 |
amod |
vitro,reaction |
R2471 |
T3721 |
T3718 |
compound |
NER,reaction |
R2472 |
T3722 |
T3718 |
acl |
reconstituted,reaction |
R2473 |
T3723 |
T3722 |
prep |
with,reconstituted |
R2474 |
T3724 |
T3725 |
amod |
different,complexes |
R2475 |
T3725 |
T3723 |
pobj |
complexes,with |
R2476 |
T3726 |
T3725 |
amod |
mutant,complexes |
R2477 |
T3727 |
T3725 |
compound |
TFIIH,complexes |
R2478 |
T3728 |
T3729 |
punct |
(,4D |
R2479 |
T3729 |
T3686 |
parataxis |
4D,exhibited |
R2480 |
T3730 |
T3729 |
compound |
Figure,4D |
R2481 |
T3731 |
T3729 |
punct |
),4D |
R2482 |
T3732 |
T3686 |
punct |
.,exhibited |
R2483 |
T3734 |
T3735 |
advcl |
Taken,are |
R2484 |
T3736 |
T3734 |
advmod |
together,Taken |
R2485 |
T3737 |
T3735 |
punct |
", ",are |
R2486 |
T3738 |
T3739 |
det |
these,data |
R2487 |
T3739 |
T3735 |
nsubj |
data,are |
R2488 |
T3740 |
T3735 |
acomp |
consistent,are |
R2489 |
T3741 |
T3740 |
prep |
with,consistent |
R2490 |
T3742 |
T3743 |
amod |
interallelic,complementation |
R2491 |
T3743 |
T3741 |
pobj |
complementation,with |
R2492 |
T3744 |
T3743 |
prep |
of,complementation |
R2493 |
T3745 |
T3746 |
compound |
UV,sensitivity |
R2494 |
T3746 |
T3744 |
pobj |
sensitivity,of |
R2495 |
T3747 |
T3743 |
prep |
in,complementation |
R2496 |
T3748 |
T3747 |
pobj |
cells,in |
R2497 |
T3749 |
T3735 |
cc |
but,are |
R2498 |
T3750 |
T3735 |
conj |
underscore,are |
R2499 |
T3751 |
T3752 |
det |
the,lack |
R2500 |
T3752 |
T3750 |
dobj |
lack,underscore |
R2501 |
T3753 |
T3752 |
prep |
of,lack |
R2502 |
T3754 |
T3755 |
det |
any,correlation |
R2503 |
T3755 |
T3753 |
pobj |
correlation,of |
R2504 |
T3756 |
T3755 |
prep |
between,correlation |
R2505 |
T3757 |
T3758 |
npadvmod |
UV,related |
R2506 |
T3758 |
T3760 |
amod |
related,characteristics |
R2507 |
T3759 |
T3758 |
punct |
-,related |
R2508 |
T3760 |
T3756 |
pobj |
characteristics,between |
R2509 |
T3761 |
T3760 |
compound |
repair,characteristics |
R2510 |
T3762 |
T3760 |
cc |
and,characteristics |
R2511 |
T3763 |
T3764 |
compound |
TTD,phenotypes |
R2512 |
T3764 |
T3760 |
conj |
phenotypes,characteristics |
R2513 |
T3765 |
T3764 |
compound |
progeroid,phenotypes |
R2514 |
T3766 |
T3755 |
prep |
in,correlation |
R2515 |
T3767 |
T3768 |
compound |
animal,models |
R2516 |
T3768 |
T3766 |
pobj |
models,in |
R2517 |
T3769 |
T3735 |
punct |
.,are |
R2439 |
T3689 |
T3688 |
prep |
of,none |
R2440 |
T3690 |
T3691 |
det |
the,combinations |