PMC:1584416 / 17108-24237 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T3312	0-9	JJ	denotes	Molecular
T3313	10-20	NNS	denotes	Mechanisms
T3314	21-23	IN	denotes	of
T3315	24-33	JJ	denotes	Biallelic
T3316	34-41	NNS	denotes	Effects
T3317	41-340	sentence	denotes	We next turned to UV-based cellular assays including unscheduled DNA synthesis after UV irradiation (UV-UDS), recovery of RNA synthesis after UV irradiation (UV-RRS), and UV survival, which report on the NER subpathways (global genome NER and transcription-coupled NER) and total NER, respectively.
T3318	42-44	PRP	denotes	We
T3319	50-56	VBD	denotes	turned
T3320	45-49	RB	denotes	next
T3321	57-59	IN	denotes	to
T3322	60-62	NN	denotes	UV
T3323	63-68	VBN	denotes	based
T3324	62-63	HYPH	denotes	-
T3325	78-84	NNS	denotes	assays
T3326	69-77	JJ	denotes	cellular
T3327	85-94	VBG	denotes	including
T3328	95-106	JJ	denotes	unscheduled
T3329	111-120	NN	denotes	synthesis
T3330	107-110	NN	denotes	DNA
T3331	121-126	IN	denotes	after
T3332	127-129	NN	denotes	UV
T3333	130-141	NN	denotes	irradiation
T3334	142-143	-LRB-	denotes	(
T3335	146-149	NN	denotes	UDS
T3336	143-145	NN	denotes	UV
T3337	145-146	HYPH	denotes	-
T3338	149-150	-RRB-	denotes	)
T3339	150-152	,	denotes	,
T3340	152-160	NN	denotes	recovery
T3341	161-163	IN	denotes	of
T3342	164-167	NN	denotes	RNA
T3343	168-177	NN	denotes	synthesis
T3344	178-183	IN	denotes	after
T3345	184-186	NN	denotes	UV
T3346	187-198	NN	denotes	irradiation
T3347	199-200	-LRB-	denotes	(
T3348	203-206	NN	denotes	RRS
T3349	200-202	NN	denotes	UV
T3350	202-203	HYPH	denotes	-
T3351	206-207	-RRB-	denotes	)
T3352	207-209	,	denotes	,
T3353	209-212	CC	denotes	and
T3354	213-215	NN	denotes	UV
T3355	216-224	NN	denotes	survival
T3356	224-226	,	denotes	,
T3357	226-231	WDT	denotes	which
T3358	232-238	VBP	denotes	report
T3359	239-241	IN	denotes	on
T3360	242-245	DT	denotes	the
T3361	250-261	NNS	denotes	subpathways
T3362	246-249	NN	denotes	NER
T3363	262-263	-LRB-	denotes	(
T3364	277-280	NN	denotes	NER
T3365	263-269	JJ	denotes	global
T3366	270-276	NN	denotes	genome
T3367	281-284	CC	denotes	and
T3368	285-298	NN	denotes	transcription
T3369	299-306	VBN	denotes	coupled
T3370	298-299	HYPH	denotes	-
T3371	307-310	NN	denotes	NER
T3372	310-311	-RRB-	denotes	)
T3373	312-315	CC	denotes	and
T3374	316-321	JJ	denotes	total
T3375	322-325	NN	denotes	NER
T3376	325-327	,	denotes	,
T3377	327-339	RB	denotes	respectively
T3378	339-340	.	denotes	.
T3379	340-466	sentence	denotes	In none of these assays was the response to UV improved in compound heterozygotes relative to TTD homozygotes (Figure 4A–4C).
T3380	341-343	IN	denotes	In
T3381	388-396	VBN	denotes	improved
T3382	344-348	NN	denotes	none
T3383	349-351	IN	denotes	of
T3384	352-357	DT	denotes	these
T3385	358-364	NNS	denotes	assays
T3386	365-368	VBD	denotes	was
T3387	369-372	DT	denotes	the
T3388	373-381	NN	denotes	response
T3389	382-384	IN	denotes	to
T3390	385-387	NN	denotes	UV
T3391	397-399	IN	denotes	in
T3392	400-408	NN	denotes	compound
T3393	409-422	NNS	denotes	heterozygotes
T3394	423-431	JJ	denotes	relative
T3395	432-434	IN	denotes	to
T3396	435-438	NN	denotes	TTD
T3397	439-450	NNS	denotes	homozygotes
T3398	451-452	-LRB-	denotes	(
T3399	459-461	NN	denotes	4A
T3400	452-458	NN	denotes	Figure
T3401	461-462	SYM	denotes	–
T3402	462-464	NN	denotes	4C
T3403	464-465	-RRB-	denotes	)
T3404	465-466	.	denotes	.
T3405	466-812	sentence	denotes	However, unlike the in vivo TTD phenotypes described above, in which XpdTTD/TTD and XpdTTD/KO animals were indistinguishable, XpdTTD dosage effects were observed in UV survival, UV-UDS, and UV-RRS, indicating that cellular parameters as measured in fibroblasts here do not always correlate with the phenotype at the level of the intact organism.
T3406	467-474	RB	denotes	However
T3407	620-628	VBN	denotes	observed
T3408	474-476	,	denotes	,
T3409	476-482	IN	denotes	unlike
T3410	483-486	DT	denotes	the
T3411	499-509	NNS	denotes	phenotypes
T3412	487-489	FW	denotes	in
T3413	490-494	FW	denotes	vivo
T3414	495-498	NN	denotes	TTD
T3415	510-519	VBN	denotes	described
T3416	520-525	RB	denotes	above
T3417	525-527	,	denotes	,
T3418	527-529	IN	denotes	in
T3419	569-573	VBD	denotes	were
T3420	530-535	WDT	denotes	which
T3421	536-542	NN	denotes	XpdTTD
T3422	543-546	NN	denotes	TTD
T3423	542-543	HYPH	denotes	/
T3424	561-568	NNS	denotes	animals
T3425	547-550	CC	denotes	and
T3426	551-557	NN	denotes	XpdTTD
T3427	558-560	NN	denotes	KO
T3428	557-558	HYPH	denotes	/
T3429	574-591	JJ	denotes	indistinguishable
T3430	591-593	,	denotes	,
T3431	593-599	NN	denotes	XpdTTD
T3432	607-614	NNS	denotes	effects
T3433	600-606	NN	denotes	dosage
T3434	615-619	VBD	denotes	were
T3435	629-631	IN	denotes	in
T3436	632-634	NN	denotes	UV
T3437	635-643	NN	denotes	survival
T3438	643-645	,	denotes	,
T3439	645-647	NN	denotes	UV
T3440	648-651	NN	denotes	UDS
T3441	647-648	HYPH	denotes	-
T3442	651-653	,	denotes	,
T3443	653-656	CC	denotes	and
T3444	657-659	NN	denotes	UV
T3445	660-663	NN	denotes	RRS
T3446	659-660	HYPH	denotes	-
T3447	663-665	,	denotes	,
T3448	665-675	VBG	denotes	indicating
T3449	676-680	IN	denotes	that
T3450	747-756	VB	denotes	correlate
T3451	681-689	JJ	denotes	cellular
T3452	690-700	NNS	denotes	parameters
T3453	701-703	IN	denotes	as
T3454	704-712	VBN	denotes	measured
T3455	713-715	IN	denotes	in
T3456	716-727	NNS	denotes	fibroblasts
T3457	728-732	RB	denotes	here
T3458	733-735	VBP	denotes	do
T3459	736-739	RB	denotes	not
T3460	740-746	RB	denotes	always
T3461	757-761	IN	denotes	with
T3462	762-765	DT	denotes	the
T3463	766-775	NN	denotes	phenotype
T3464	776-778	IN	denotes	at
T3465	779-782	DT	denotes	the
T3466	783-788	NN	denotes	level
T3467	789-791	IN	denotes	of
T3468	792-795	DT	denotes	the
T3469	803-811	NN	denotes	organism
T3470	796-802	JJ	denotes	intact
T3471	811-812	.	denotes	.
T3472	812-935	sentence	denotes	XpdTTD/KO hemizygous cells were thus used as the baseline on which to compare the activity of compound heterozygous cells.
T3473	813-819	NN	denotes	XpdTTD
T3474	820-822	NN	denotes	KO
T3475	819-820	HYPH	denotes	/
T3476	834-839	NNS	denotes	cells
T3477	823-833	JJ	denotes	hemizygous
T3478	850-854	VBN	denotes	used
T3479	840-844	VBD	denotes	were
T3480	845-849	RB	denotes	thus
T3481	855-857	IN	denotes	as
T3482	858-861	DT	denotes	the
T3483	862-870	NN	denotes	baseline
T3484	871-873	IN	denotes	on
T3485	883-890	VB	denotes	compare
T3486	874-879	WDT	denotes	which
T3487	880-882	TO	denotes	to
T3488	891-894	DT	denotes	the
T3489	895-903	NN	denotes	activity
T3490	904-906	IN	denotes	of
T3491	907-915	NN	denotes	compound
T3492	929-934	NNS	denotes	cells
T3493	916-928	JJ	denotes	heterozygous
T3494	934-935	.	denotes	.
T3495	935-1142	sentence	denotes	Relative to XpdTTD/KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd†XPCS allele in XpdTTD/†XPCS compound heterozygous cells and to a lesser degree by the Xpd†XP allele (Figure 4A).
T3496	936-944	JJ	denotes	Relative
T3497	992-1000	VBN	denotes	improved
T3498	945-947	IN	denotes	to
T3499	948-954	NN	denotes	XpdTTD
T3500	955-957	NN	denotes	KO
T3501	954-955	HYPH	denotes	/
T3502	969-974	NNS	denotes	cells
T3503	958-968	NN	denotes	hemizygote
T3504	974-976	,	denotes	,
T3505	976-978	NN	denotes	UV
T3506	979-987	NN	denotes	survival
T3507	988-991	VBD	denotes	was
T3508	1001-1003	IN	denotes	by
T3509	1004-1007	DT	denotes	the
T3510	1035-1041	NN	denotes	allele
T3511	1008-1018	JJ	denotes	homozygous
T3512	1019-1025	JJ	denotes	lethal
T3513	1026-1034	NN	denotes	Xpd†XPCS
T3514	1042-1044	IN	denotes	in
T3515	1045-1051	NN	denotes	XpdTTD
T3516	1052-1057	NN	denotes	†XPCS
T3517	1051-1052	HYPH	denotes	/
T3518	1080-1085	NNS	denotes	cells
T3519	1058-1066	NN	denotes	compound
T3520	1067-1079	JJ	denotes	heterozygous
T3521	1086-1089	CC	denotes	and
T3522	1090-1092	IN	denotes	to
T3523	1109-1111	IN	denotes	by
T3524	1093-1094	DT	denotes	a
T3525	1102-1108	NN	denotes	degree
T3526	1095-1101	JJR	denotes	lesser
T3527	1112-1115	DT	denotes	the
T3528	1123-1129	NN	denotes	allele
T3529	1116-1122	NN	denotes	Xpd†XP
T3530	1130-1131	-LRB-	denotes	(
T3531	1138-1140	NN	denotes	4A
T3532	1131-1137	NN	denotes	Figure
T3533	1140-1141	-RRB-	denotes	)
T3534	1141-1142	.	denotes	.
T3535	1142-1282	sentence	denotes	Because of embryonic and cellular lethality, we were unable to test UV survival associated exclusively with the Xpd†XPCS or Xpd†XP alleles.
T3536	1143-1150	IN	denotes	Because
T3537	1191-1195	VBD	denotes	were
T3538	1151-1153	IN	denotes	of
T3539	1154-1163	JJ	denotes	embryonic
T3540	1177-1186	NN	denotes	lethality
T3541	1164-1167	CC	denotes	and
T3542	1168-1176	JJ	denotes	cellular
T3543	1186-1188	,	denotes	,
T3544	1188-1190	PRP	denotes	we
T3545	1196-1202	JJ	denotes	unable
T3546	1203-1205	TO	denotes	to
T3547	1206-1210	VB	denotes	test
T3548	1211-1213	NN	denotes	UV
T3549	1214-1222	NN	denotes	survival
T3550	1223-1233	VBN	denotes	associated
T3551	1234-1245	RB	denotes	exclusively
T3552	1246-1250	IN	denotes	with
T3553	1251-1254	DT	denotes	the
T3554	1274-1281	NNS	denotes	alleles
T3555	1255-1263	NN	denotes	Xpd†XPCS
T3556	1264-1266	CC	denotes	or
T3557	1267-1273	NN	denotes	Xpd†XP
T3558	1281-1282	.	denotes	.
T3559	1282-1524	sentence	denotes	However, homozygous XPDXP (XPDR683W) and hemizygous XPDXPCS (XPDG602D) human cells are known to be highly sensitive to UV [19,25], as are cells from a homozygous viable XpdXPCS/XPCS (XPDG602D/G602D) mouse model (Figure 4A, dotted line) [23].
T3560	1283-1290	RB	denotes	However
T3561	1370-1375	VBN	denotes	known
T3562	1290-1292	,	denotes	,
T3563	1292-1302	JJ	denotes	homozygous
T3564	1303-1308	NN	denotes	XPDXP
T3565	1360-1365	NNS	denotes	cells
T3566	1309-1310	-LRB-	denotes	(
T3567	1310-1318	NN	denotes	XPDR683W
T3568	1318-1319	-RRB-	denotes	)
T3569	1320-1323	CC	denotes	and
T3570	1324-1334	JJ	denotes	hemizygous
T3571	1335-1342	NN	denotes	XPDXPCS
T3572	1343-1344	-LRB-	denotes	(
T3573	1344-1352	NN	denotes	XPDG602D
T3574	1352-1353	-RRB-	denotes	)
T3575	1354-1359	JJ	denotes	human
T3576	1366-1369	VBP	denotes	are
T3577	1376-1378	TO	denotes	to
T3578	1379-1381	VB	denotes	be
T3579	1382-1388	RB	denotes	highly
T3580	1389-1398	JJ	denotes	sensitive
T3581	1399-1401	IN	denotes	to
T3582	1402-1404	NN	denotes	UV
T3583	1405-1406	-LRB-	denotes	[
T3584	1409-1411	CD	denotes	25
T3585	1406-1408	CD	denotes	19
T3586	1408-1409	,	denotes	,
T3587	1411-1412	-RRB-	denotes	]
T3588	1412-1414	,	denotes	,
T3589	1414-1416	IN	denotes	as
T3590	1417-1420	VBP	denotes	are
T3591	1421-1426	NNS	denotes	cells
T3592	1427-1431	IN	denotes	from
T3593	1432-1433	DT	denotes	a
T3594	1488-1493	NN	denotes	model
T3595	1434-1444	JJ	denotes	homozygous
T3596	1445-1451	JJ	denotes	viable
T3597	1452-1459	NN	denotes	XpdXPCS
T3598	1460-1464	NN	denotes	XPCS
T3599	1459-1460	HYPH	denotes	/
T3600	1465-1466	-LRB-	denotes	(
T3601	1475-1480	NN	denotes	G602D
T3602	1466-1474	NN	denotes	XPDG602D
T3603	1474-1475	HYPH	denotes	/
T3604	1480-1481	-RRB-	denotes	)
T3605	1482-1487	NN	denotes	mouse
T3606	1494-1495	-LRB-	denotes	(
T3607	1502-1504	NN	denotes	4A
T3608	1495-1501	NN	denotes	Figure
T3609	1504-1506	,	denotes	,
T3610	1506-1512	VBN	denotes	dotted
T3611	1513-1517	NN	denotes	line
T3612	1517-1518	-RRB-	denotes	)
T3613	1519-1520	-LRB-	denotes	[
T3614	1520-1522	CD	denotes	23
T3615	1522-1523	-RRB-	denotes	]
T3616	1523-1524	.	denotes	.
T3617	1524-1685	sentence	denotes	Thus, the survival of XpdTTD/†XPCS (and XpdTTD/†XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).
T3618	1525-1529	RB	denotes	Thus
T3619	1590-1600	VBZ	denotes	represents
T3620	1529-1531	,	denotes	,
T3621	1531-1534	DT	denotes	the
T3622	1535-1543	NN	denotes	survival
T3623	1544-1546	IN	denotes	of
T3624	1547-1553	NN	denotes	XpdTTD
T3625	1554-1559	NN	denotes	†XPCS
T3626	1553-1554	HYPH	denotes	/
T3627	1577-1582	NNS	denotes	cells
T3628	1560-1561	-LRB-	denotes	(
T3629	1561-1564	CC	denotes	and
T3630	1565-1571	NN	denotes	XpdTTD
T3631	1572-1575	NN	denotes	†XP
T3632	1571-1572	HYPH	denotes	/
T3633	1575-1576	-RRB-	denotes	)
T3634	1583-1589	RB	denotes	likely
T3635	1601-1602	DT	denotes	a
T3636	1603-1608	NN	denotes	level
T3637	1609-1611	IN	denotes	of
T3638	1612-1614	NN	denotes	UV
T3639	1615-1625	NN	denotes	resistance
T3640	1626-1630	WDT	denotes	that
T3641	1657-1663	VB	denotes	impart
T3642	1631-1638	CC	denotes	neither
T3643	1646-1652	NN	denotes	allele
T3644	1639-1645	JJ	denotes	mutant
T3645	1653-1656	MD	denotes	can
T3646	1664-1666	IN	denotes	on
T3647	1667-1670	PRP$	denotes	its
T3648	1671-1674	NN	denotes	own
T3649	1675-1676	-LRB-	denotes	(
T3650	1676-1681	NN	denotes	Table
T3651	1682-1683	CD	denotes	2
T3652	1683-1684	-RRB-	denotes	)
T3653	1684-1685	.	denotes	.
T3654	1685-1843	sentence	denotes	Significant effects of compound heterozygosity on NER subpathways relative to XpdTTD/KO cells were observed in XpdTTD/†XP cells but only for UV-UDS activity.
T3655	1686-1697	JJ	denotes	Significant
T3656	1698-1705	NNS	denotes	effects
T3657	1785-1793	VBN	denotes	observed
T3658	1706-1708	IN	denotes	of
T3659	1709-1717	NN	denotes	compound
T3660	1718-1732	NN	denotes	heterozygosity
T3661	1733-1735	IN	denotes	on
T3662	1736-1739	NN	denotes	NER
T3663	1740-1751	NNS	denotes	subpathways
T3664	1752-1760	JJ	denotes	relative
T3665	1761-1763	IN	denotes	to
T3666	1764-1770	NN	denotes	XpdTTD
T3667	1771-1773	NN	denotes	KO
T3668	1770-1771	HYPH	denotes	/
T3669	1774-1779	NNS	denotes	cells
T3670	1780-1784	VBD	denotes	were
T3671	1794-1796	IN	denotes	in
T3672	1797-1803	NN	denotes	XpdTTD
T3673	1804-1807	NN	denotes	†XP
T3674	1803-1804	HYPH	denotes	/
T3675	1808-1813	NNS	denotes	cells
T3676	1814-1817	CC	denotes	but
T3677	1818-1822	RB	denotes	only
T3678	1823-1826	IN	denotes	for
T3679	1827-1829	NN	denotes	UV
T3680	1830-1833	NN	denotes	UDS
T3681	1829-1830	HYPH	denotes	-
T3682	1834-1842	NN	denotes	activity
T3683	1842-1843	.	denotes	.
T3684	1843-2092	sentence	denotes	Finally, none of the mutant TFIIH combinations (carrying alterations associated with TTD [XPDR722W], XPCS [XPDG602D], or XP [XPDR683W]) exhibited synergism in an in vitro NER reaction reconstituted with different mutant TFIIH complexes (Figure 4D).
T3685	1844-1851	RB	denotes	Finally
T3686	1980-1989	VBD	denotes	exhibited
T3687	1851-1853	,	denotes	,
T3688	1853-1857	NN	denotes	none
T3689	1858-1860	IN	denotes	of
T3690	1861-1864	DT	denotes	the
T3691	1878-1890	NNS	denotes	combinations
T3692	1865-1871	JJ	denotes	mutant
T3693	1872-1877	NN	denotes	TFIIH
T3694	1891-1892	-LRB-	denotes	(
T3695	1892-1900	VBG	denotes	carrying
T3696	1901-1912	NNS	denotes	alterations
T3697	1913-1923	VBN	denotes	associated
T3698	1924-1928	IN	denotes	with
T3699	1929-1932	NN	denotes	TTD
T3700	1933-1934	-LRB-	denotes	[
T3701	1934-1942	NN	denotes	XPDR722W
T3702	1942-1943	-RRB-	denotes	]
T3703	1943-1945	,	denotes	,
T3704	1945-1949	NN	denotes	XPCS
T3705	1950-1951	-LRB-	denotes	[
T3706	1951-1959	NN	denotes	XPDG602D
T3707	1959-1960	-RRB-	denotes	]
T3708	1960-1962	,	denotes	,
T3709	1962-1964	CC	denotes	or
T3710	1965-1967	NN	denotes	XP
T3711	1968-1969	-LRB-	denotes	[
T3712	1969-1977	NN	denotes	XPDR683W
T3713	1977-1978	-RRB-	denotes	]
T3714	1978-1979	-RRB-	denotes	)
T3715	1990-1999	NN	denotes	synergism
T3716	2000-2002	IN	denotes	in
T3717	2003-2005	DT	denotes	an
T3718	2019-2027	NN	denotes	reaction
T3719	2006-2008	FW	denotes	in
T3720	2009-2014	FW	denotes	vitro
T3721	2015-2018	NN	denotes	NER
T3722	2028-2041	VBN	denotes	reconstituted
T3723	2042-2046	IN	denotes	with
T3724	2047-2056	JJ	denotes	different
T3725	2070-2079	NNS	denotes	complexes
T3726	2057-2063	JJ	denotes	mutant
T3727	2064-2069	NN	denotes	TFIIH
T3728	2080-2081	-LRB-	denotes	(
T3729	2088-2090	NN	denotes	4D
T3730	2081-2087	NN	denotes	Figure
T3731	2090-2091	-RRB-	denotes	)
T3732	2091-2092	.	denotes	.
T3733	2092-2327	sentence	denotes	Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV-related repair characteristics and TTD progeroid phenotypes in animal models.
T3734	2093-2098	VBN	denotes	Taken
T3735	2120-2123	VBP	denotes	are
T3872	5495-5503	NNS	denotes	patients
T3873	5504-5508	IN	denotes	with
T3874	5509-5512	NN	denotes	TTD
T3875	5513-5521	VBN	denotes	compared
T3876	5522-5526	IN	denotes	with
T3877	5527-5529	NN	denotes	wt
T3878	5530-5538	NNS	denotes	controls
T3879	5539-5542	IN	denotes	due
T3880	5543-5545	IN	denotes	to
T3881	5546-5553	VBN	denotes	reduced
T3882	5554-5563	NN	denotes	stability
T3883	5564-5565	-LRB-	denotes	[
T3884	5568-5570	CD	denotes	17
T3885	5565-5567	CD	denotes	16
T3886	5567-5568	,	denotes	,
T3887	5570-5571	-RRB-	denotes	]
T3888	5571-5572	.	denotes	.
T3889	5572-5826	sentence	denotes	Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50% in primary mouse XpdTTD/TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.
T3890	5573-5580	IN	denotes	Despite
T3891	5692-5699	VBN	denotes	reduced
T3892	5581-5595	NN	denotes	overexpression
T3893	5596-5598	IN	denotes	of
T3894	5599-5603	NN	denotes	mRNA
T3895	5604-5608	IN	denotes	from
T3896	5609-5612	DT	denotes	the
T3897	5620-5626	NN	denotes	allele
T3898	5613-5619	NN	denotes	XpdTTD
T3899	5627-5635	JJ	denotes	relative
T3900	5636-5638	IN	denotes	to
T3901	5639-5642	DT	denotes	the
T3902	5646-5652	NN	denotes	allele
T3903	5643-5645	NN	denotes	wt
T3904	5653-5654	-LRB-	denotes	(
T3905	5661-5663	NN	denotes	1E
T3906	5654-5660	NN	denotes	Figure
T3907	5663-5664	-RRB-	denotes	)
T3908	5664-5666	,	denotes	,
T3909	5666-5671	NN	denotes	TFIIH
T3910	5680-5686	NNS	denotes	levels
T3911	5672-5679	NN	denotes	protein
T3912	5687-5691	VBD	denotes	were
T3913	5700-5702	IN	denotes	by
T3914	5703-5705	CD	denotes	50
T3915	5705-5706	NN	denotes	%
T3916	5707-5709	IN	denotes	in
T3917	5710-5717	JJ	denotes	primary
T3918	5735-5746	NNS	denotes	fibroblasts
T3919	5718-5723	NN	denotes	mouse
T3920	5724-5730	NN	denotes	XpdTTD
T3921	5731-5734	NN	denotes	TTD
T3922	5730-5731	HYPH	denotes	/
T3923	5747-5748	-LRB-	denotes	(
T3924	5755-5757	NN	denotes	4E
T3925	5748-5754	NN	denotes	Figure
T3926	5758-5761	CC	denotes	and
T3927	5762-5764	NN	denotes	4F
T3928	5764-5765	-RRB-	denotes	)
T3929	5765-5767	,	denotes	,
T3930	5767-5774	RB	denotes	thereby
T3931	5775-5784	VBG	denotes	mimicking
T3932	5785-5788	DT	denotes	the
T3933	5789-5798	NN	denotes	situation
T3934	5799-5801	IN	denotes	in
T3935	5802-5807	JJ	denotes	human
T3936	5808-5816	NNS	denotes	patients
T3937	5817-5821	IN	denotes	with
T3938	5822-5825	NN	denotes	TTD
T3939	5825-5826	.	denotes	.
T3940	5826-5955	sentence	denotes	In accordance with the gene dosage, a further reduction of up to 70% of the wt level was observed in hemizygous XpdTTD/KO cells.
T3941	5827-5829	IN	denotes	In
T3942	5916-5924	VBN	denotes	observed
T3943	5830-5840	NN	denotes	accordance
T3944	5841-5845	IN	denotes	with
T3945	5846-5849	DT	denotes	the
T3946	5855-5861	NN	denotes	dosage
T3947	5850-5854	NN	denotes	gene
T3948	5861-5863	,	denotes	,
T3949	5863-5864	DT	denotes	a
T3950	5873-5882	NN	denotes	reduction
T3951	5865-5872	JJ	denotes	further
T3952	5883-5885	IN	denotes	of
T3953	5886-5888	IN	denotes	up
T3954	5892-5894	CD	denotes	70
T3955	5889-5891	IN	denotes	to
T3956	5894-5895	NN	denotes	%
T3957	5896-5898	IN	denotes	of
T3958	5899-5902	DT	denotes	the
T3959	5906-5911	NN	denotes	level
T3960	5903-5905	NN	denotes	wt
T3961	5912-5915	VBD	denotes	was
T3962	5925-5927	IN	denotes	in
T3963	5928-5938	JJ	denotes	hemizygous
T3964	5949-5954	NNS	denotes	cells
T3965	5939-5945	NN	denotes	XpdTTD
T3966	5946-5948	NN	denotes	KO
T3967	5945-5946	HYPH	denotes	/
T3968	5954-5955	.	denotes	.
T3969	5955-6149	sentence	denotes	Consistent with low mRNA expression levels, neither the Xpd†XPCS nor the Xpd†XP allele was able to restore TFIIH abundance to wt levels in XpdTTD compound heterozygote cells (Figure 4E and 4F).
T3970	5956-5966	JJ	denotes	Consistent
T3971	6043-6046	VBD	denotes	was
T3972	5967-5971	IN	denotes	with
T3973	5972-5975	JJ	denotes	low
T3974	5992-5998	NNS	denotes	levels
T3975	5976-5980	NN	denotes	mRNA
T3976	5981-5991	NN	denotes	expression
T3977	5998-6000	,	denotes	,
T3978	6000-6007	CC	denotes	neither
T3979	6036-6042	NN	denotes	allele
T3980	6008-6011	DT	denotes	the
T3981	6012-6020	NN	denotes	Xpd†XPCS
T3982	6021-6024	CC	denotes	nor
T3983	6025-6028	DT	denotes	the
T3984	6029-6035	NN	denotes	Xpd†XP
T3985	6047-6051	JJ	denotes	able
T3986	6052-6054	TO	denotes	to
T3987	6055-6062	VB	denotes	restore
T3988	6063-6068	NN	denotes	TFIIH
T3989	6069-6078	NN	denotes	abundance
T3990	6079-6081	IN	denotes	to
T3991	6082-6084	NN	denotes	wt
T3992	6085-6091	NNS	denotes	levels
T3993	6092-6094	IN	denotes	in
T3994	6095-6101	NN	denotes	XpdTTD
T3995	6124-6129	NNS	denotes	cells
T3996	6102-6110	NN	denotes	compound
T3997	6111-6123	NN	denotes	heterozygote
T3998	6130-6131	-LRB-	denotes	(
T3999	6138-6140	NN	denotes	4E
T4000	6131-6137	NN	denotes	Figure
T4001	6141-6144	CC	denotes	and
T4002	6145-6147	NN	denotes	4F
T4003	6147-6148	-RRB-	denotes	)
T4004	6148-6149	.	denotes	.
T4005	6149-6426	sentence	denotes	Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.
T4006	6150-6154	RB	denotes	Thus
T4007	6292-6296	VBD	denotes	were
T4008	6154-6156	,	denotes	,
T4009	6156-6159	DT	denotes	the
T4010	6172-6180	NN	denotes	survival
T4011	6160-6168	VBN	denotes	improved
T4012	6169-6171	NN	denotes	UV
T4013	6181-6189	VBN	denotes	observed
T4014	6190-6192	IN	denotes	in
T4015	6193-6201	NN	denotes	compound
T4016	6215-6220	NNS	denotes	cells
T4017	6202-6214	NN	denotes	heterozygote
T4018	6221-6222	-LRB-	denotes	(
T4019	6229-6231	NN	denotes	4A
T4020	6222-6228	NN	denotes	Figure
T4021	6231-6232	-RRB-	denotes	)
T4022	6233-6236	CC	denotes	and
T4023	6237-6243	RB	denotes	likely
T4024	6248-6254	NN	denotes	rescue
T4025	6244-6247	DT	denotes	the
T4026	6255-6257	IN	denotes	of
T4027	6258-6261	NN	denotes	TTD
T4028	6272-6280	NNS	denotes	symptoms
T4029	6262-6271	NN	denotes	progeroid
T4030	6281-6282	-LRB-	denotes	(
T4031	6282-6288	NN	denotes	Figure
T4032	6289-6290	CD	denotes	3
T4033	6290-6291	-RRB-	denotes	)
T4034	6297-6300	RB	denotes	not
T4035	6301-6304	IN	denotes	due
T4036	6305-6307	IN	denotes	to
T4037	6308-6321	NN	denotes	normalisation
T4038	6322-6324	IN	denotes	of
T4039	6325-6330	NN	denotes	TFIIH
T4040	6331-6337	NNS	denotes	levels
T4041	6337-6339	,	denotes	,
T4042	6339-6349	VBG	denotes	suggesting
T4043	6350-6351	DT	denotes	a
T4044	6352-6363	JJ	denotes	qualitative
T4045	6391-6397	NN	denotes	effect
T4046	6364-6370	RB	denotes	rather
T4047	6371-6375	IN	denotes	than
T4048	6376-6377	DT	denotes	a
T4049	6378-6390	JJ	denotes	quantitative
T4050	6398-6400	IN	denotes	on
T4051	6401-6406	DT	denotes	these
T4052	6407-6417	NNS	denotes	phenotypes
T4053	6418-6420	FW	denotes	in
T4054	6421-6425	FW	denotes	vivo
T4055	6425-6426	.	denotes	.
T4056	6426-6575	sentence	denotes	In contrast, the level of XPCS mRNA expression did affect the ability of the encoded protein (XPDG602D) to restore the TTD hair phenotype to normal.
T4057	6427-6429	IN	denotes	In
T4058	6478-6484	VB	denotes	affect
T4059	6430-6438	NN	denotes	contrast
T4060	6438-6440	,	denotes	,
T4061	6440-6443	DT	denotes	the
T4062	6444-6449	NN	denotes	level
T4063	6450-6452	IN	denotes	of
T4064	6453-6457	NN	denotes	XPCS
T4065	6463-6473	NN	denotes	expression
T4066	6458-6462	NN	denotes	mRNA
T4067	6474-6477	VBD	denotes	did
T4068	6485-6488	DT	denotes	the
T4069	6489-6496	NN	denotes	ability
T4070	6497-6499	IN	denotes	of
T4071	6500-6503	DT	denotes	the
T4072	6512-6519	NN	denotes	protein
T4073	6504-6511	VBN	denotes	encoded
T4074	6520-6521	-LRB-	denotes	(
T4075	6521-6529	NN	denotes	XPDG602D
T4076	6529-6530	-RRB-	denotes	)
T4077	6531-6533	TO	denotes	to
T4078	6534-6541	VB	denotes	restore
T4079	6542-6545	DT	denotes	the
T4080	6555-6564	NN	denotes	phenotype
T4081	6546-6549	NN	denotes	TTD
T4082	6550-6554	NN	denotes	hair
T4083	6565-6567	IN	denotes	to
T4086	6575-6838	sentence	denotes	Notably, XpdTTD/ †XPCS animals had a partial TTD hair phenotype, correlating with low levels of Xpd†XPCS expression, whereas XpdTTD/XPCS animals had wt hair, correlating with normal expression levels from the viable XpdXPCS allele (Table 2 and unpublished data).
T4087	6576-6583	RB	denotes	Notably
T4088	6607-6610	VBD	denotes	had
T4089	6583-6585	,	denotes	,
T4090	6585-6591	NN	denotes	XpdTTD
T4091	6592-6598	NN	denotes	†XPCS
T4092	6591-6592	HYPH	denotes	/
T4093	6599-6606	NNS	denotes	animals
T4094	6611-6612	DT	denotes	a
T4095	6630-6639	NN	denotes	phenotype
T4096	6613-6620	JJ	denotes	partial
T4097	6621-6624	NN	denotes	TTD
T4098	6625-6629	NN	denotes	hair
T4099	6639-6641	,	denotes	,
T4100	6641-6652	VBG	denotes	correlating
T4101	6653-6657	IN	denotes	with
T4102	6658-6661	JJ	denotes	low
T4103	6662-6668	NNS	denotes	levels
T4104	6669-6671	IN	denotes	of
T4105	6672-6680	NN	denotes	Xpd†XPCS
T4106	6681-6691	NN	denotes	expression
T4107	6691-6693	,	denotes	,
T4108	6693-6700	IN	denotes	whereas
T4109	6721-6724	VBD	denotes	had
T4110	6701-6707	NN	denotes	XpdTTD
T4111	6708-6712	NN	denotes	XPCS
T4112	6707-6708	HYPH	denotes	/
T4113	6713-6720	NNS	denotes	animals
T4114	6725-6727	NN	denotes	wt
T4115	6728-6732	NN	denotes	hair
T4116	6732-6734	,	denotes	,
T4117	6734-6745	VBG	denotes	correlating
T4118	6746-6750	IN	denotes	with
T4119	6751-6757	JJ	denotes	normal
T4120	6769-6775	NNS	denotes	levels
T4121	6758-6768	NN	denotes	expression
T4122	6776-6780	IN	denotes	from
T4123	6781-6784	DT	denotes	the
T4124	6800-6806	NN	denotes	allele
T4125	6785-6791	JJ	denotes	viable
T4126	6792-6799	NN	denotes	XpdXPCS
T4127	6807-6808	-LRB-	denotes	(
T4128	6808-6813	NN	denotes	Table
T4129	6814-6815	CD	denotes	2
T4130	6816-6819	CC	denotes	and
T4131	6820-6831	JJ	denotes	unpublished
T4132	6832-6836	NNS	denotes	data
T4133	6836-6837	-RRB-	denotes	)
T4134	6837-6838	.	denotes	.
T4135	6838-6966	sentence	denotes	Thus, the range of expression levels from these two mutant alleles affected their ability to complement some phenotypes (hair).
T4136	6839-6843	RB	denotes	Thus
T4137	6906-6914	VBD	denotes	affected
T4138	6843-6845	,	denotes	,
T4139	6845-6848	DT	denotes	the
T4140	6849-6854	NN	denotes	range
T4141	6855-6857	IN	denotes	of
T4142	6858-6868	NN	denotes	expression
T4143	6869-6875	NNS	denotes	levels
T4144	6876-6880	IN	denotes	from
T4145	6881-6886	DT	denotes	these
T4146	6898-6905	NNS	denotes	alleles
T4147	6887-6890	CD	denotes	two
T4148	6891-6897	JJ	denotes	mutant
T4149	6915-6920	PRP$	denotes	their
T4150	6921-6928	NN	denotes	ability
T4151	6929-6931	TO	denotes	to
T4152	6932-6942	VB	denotes	complement
T4153	6943-6947	DT	denotes	some
T4154	6948-6958	NNS	denotes	phenotypes
T4155	6959-6960	-LRB-	denotes	(
T4156	6960-6964	NN	denotes	hair
T4157	6964-6965	-RRB-	denotes	)
T4158	6965-6966	.	denotes	.
T4159	6966-7129	sentence	denotes	An overview of the functional relationships between Xpd alleles, phenotypes, and the presumed underlying TFIIH function in mice and cells is presented in Table 2.
T4160	6967-6969	DT	denotes	An
T4161	6970-6978	NN	denotes	overview
T4162	7108-7117	VBN	denotes	presented
T4163	6979-6981	IN	denotes	of
T4164	6982-6985	DT	denotes	the
T4165	6997-7010	NNS	denotes	relationships
T4166	6986-6996	JJ	denotes	functional
T4167	7011-7018	IN	denotes	between
T4168	7019-7022	NN	denotes	Xpd
T4169	7023-7030	NNS	denotes	alleles
T4170	7030-7032	,	denotes	,
T4171	7032-7042	NNS	denotes	phenotypes
T4172	7042-7044	,	denotes	,
T4173	7044-7047	CC	denotes	and
T4174	7048-7051	DT	denotes	the
T4175	7078-7086	NN	denotes	function
T4176	7052-7060	VBN	denotes	presumed
T4177	7061-7071	VBG	denotes	underlying
T4178	7072-7077	NN	denotes	TFIIH
T4179	7087-7089	IN	denotes	in
T4180	7090-7094	NNS	denotes	mice
T4181	7095-7098	CC	denotes	and
T4182	7099-7104	NNS	denotes	cells
T4183	7105-7107	VBZ	denotes	is
T4184	7118-7120	IN	denotes	in
T4185	7121-7126	NN	denotes	Table
T4186	7127-7128	CD	denotes	2
T4187	7128-7129	.	denotes	.
T8564	2338-2343	NN	denotes	TFIIH
T8565	2344-2353	NNS	denotes	Functions
T8566	2354-2357	CC	denotes	and
T8567	2358-2368	NNS	denotes	Mechanisms
T8568	2369-2371	IN	denotes	of
T8569	2372-2375	NN	denotes	XPD
T8570	2376-2386	VBN	denotes	Associated
T8571	2375-2376	HYPH	denotes	-
T8572	2395-2405	NN	denotes	Pleiotropy
T8573	2387-2394	NN	denotes	Disease
T8574	2405-2449	sentence	denotes	(A) Cellular survival after UV irradiation.
T8575	2406-2407	-LRB-	denotes	(
T8576	2407-2408	LS	denotes	A
T8577	2419-2427	NN	denotes	survival
T8578	2408-2409	-RRB-	denotes	)
T8579	2410-2418	JJ	denotes	Cellular
T8580	2428-2433	IN	denotes	after
T8581	2434-2436	NN	denotes	UV
T8582	2437-2448	NN	denotes	irradiation
T8583	2448-2449	.	denotes	.
T8584	2449-2575	sentence	denotes	Rescue of hemizygous XpdTTD/KO survival by Xpd†XPCS and Xpd†XP alleles is illustrated by arrows marked A and B, respectively.
T8585	2450-2456	NN	denotes	Rescue
T8586	2524-2535	VBN	denotes	illustrated
T8587	2457-2459	IN	denotes	of
T8588	2460-2470	JJ	denotes	hemizygous
T8589	2481-2489	NN	denotes	survival
T8590	2471-2477	NN	denotes	XpdTTD
T8591	2478-2480	NN	denotes	KO
T8592	2477-2478	HYPH	denotes	/
T8593	2490-2492	IN	denotes	by
T8594	2493-2501	NN	denotes	Xpd†XPCS
T8595	2513-2520	NNS	denotes	alleles
T8596	2502-2505	CC	denotes	and
T8597	2506-2512	NN	denotes	Xpd†XP
T8598	2521-2523	VBZ	denotes	is
T8599	2536-2538	IN	denotes	by
T8600	2539-2545	NNS	denotes	arrows
T8601	2546-2552	VBN	denotes	marked
T8602	2553-2554	NN	denotes	A
T8603	2555-2558	CC	denotes	and
T8604	2559-2560	NN	denotes	B
T8605	2560-2562	,	denotes	,
T8606	2562-2574	RB	denotes	respectively
T8607	2574-2575	.	denotes	.
T8608	2575-2713	sentence	denotes	UV survival of homozygous XpdXPCS/XPCS cells (asterisk) from the normally expressed viable allele (XpdXPCS) is depicted by a dotted line.
T8609	2576-2578	NN	denotes	UV
T8610	2579-2587	NN	denotes	survival
T8611	2687-2695	VBN	denotes	depicted
T8612	2588-2590	IN	denotes	of
T8613	2591-2601	JJ	denotes	homozygous
T8614	2615-2620	NNS	denotes	cells
T8615	2602-2609	NN	denotes	XpdXPCS
T8616	2610-2614	NN	denotes	XPCS
T8617	2609-2610	HYPH	denotes	/
T8618	2621-2622	-LRB-	denotes	(
T8619	2622-2630	NN	denotes	asterisk
T8620	2630-2631	-RRB-	denotes	)
T8621	2632-2636	IN	denotes	from
T8622	2637-2640	DT	denotes	the
T8623	2667-2673	NN	denotes	allele
T8624	2641-2649	RB	denotes	normally
T8625	2650-2659	VBN	denotes	expressed
T8626	2660-2666	JJ	denotes	viable
T8627	2674-2675	-LRB-	denotes	(
T8628	2675-2682	NN	denotes	XpdXPCS
T8629	2682-2683	-RRB-	denotes	)
T8630	2684-2686	VBZ	denotes	is
T8631	2696-2698	IN	denotes	by
T8632	2699-2700	DT	denotes	a
T8633	2708-2712	NN	denotes	line
T8634	2701-2707	VBN	denotes	dotted
T8635	2712-2713	.	denotes	.
T8636	2713-2845	sentence	denotes	Survival curves represent an average of four independent experiments; 1–2 cell lines per genotype were included in each experiment.
T8637	2714-2722	NN	denotes	Survival
T8638	2723-2729	NNS	denotes	curves
T8639	2730-2739	VBP	denotes	represent
T8640	2817-2825	VBN	denotes	included
T8641	2740-2742	DT	denotes	an
T8642	2743-2750	NN	denotes	average
T8643	2751-2753	IN	denotes	of
T8644	2754-2758	CD	denotes	four
T8645	2771-2782	NNS	denotes	experiments
T8646	2759-2770	JJ	denotes	independent
T8647	2782-2783	:	denotes	;
T8648	2784-2785	CD	denotes	1
T8649	2786-2787	CD	denotes	2
T8650	2785-2786	SYM	denotes	–
T8651	2793-2798	NNS	denotes	lines
T8652	2788-2792	NN	denotes	cell
T8653	2799-2802	IN	denotes	per
T8654	2803-2811	NN	denotes	genotype
T8655	2812-2816	VBD	denotes	were
T8656	2826-2828	IN	denotes	in
T8657	2829-2833	DT	denotes	each
T8658	2834-2844	NN	denotes	experiment
T8659	2844-2845	.	denotes	.
T8660	2845-2890	sentence	denotes	Error bars indicate SEM between experiments.
T8661	2846-2851	NN	denotes	Error
T8662	2852-2856	NNS	denotes	bars
T8663	2857-2865	VBP	denotes	indicate
T8664	2866-2869	NN	denotes	SEM
T8665	2870-2877	IN	denotes	between
T8666	2878-2889	NNS	denotes	experiments
T8667	2889-2890	.	denotes	.
T8668	2890-2937	sentence	denotes	(B) UV-UDS, a measure of global genome repair.
T8669	2891-2892	-LRB-	denotes	(
T8670	2892-2893	LS	denotes	B
T8671	2898-2901	NN	denotes	UDS
T8672	2893-2894	-RRB-	denotes	)
T8673	2895-2897	NN	denotes	UV
T8674	2897-2898	HYPH	denotes	-
T8675	2901-2903	,	denotes	,
T8676	2903-2904	DT	denotes	a
T8677	2905-2912	NN	denotes	measure
T8678	2913-2915	IN	denotes	of
T8679	2916-2922	JJ	denotes	global
T8680	2930-2936	NN	denotes	repair
T8681	2923-2929	NN	denotes	genome
T8682	2936-2937	.	denotes	.
T8683	2937-3106	sentence	denotes	Number of experiments: n = 15 (XpdTTD/TTD), n = 6 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8684	2938-2944	NN	denotes	Number
T8685	3078-3086	VBN	denotes	included
T8686	2945-2947	IN	denotes	of
T8687	2948-2959	NNS	denotes	experiments
T8688	2959-2961	:	denotes	:
T8689	2961-2962	NN	denotes	n
T8690	2965-2967	CD	denotes	15
T8691	2963-2964	SYM	denotes	=
T8692	2968-2969	-LRB-	denotes	(
T8693	2969-2975	NN	denotes	XpdTTD
T8694	2975-2976	SYM	denotes	/
T8695	2976-2979	NN	denotes	TTD
T8696	2979-2980	-RRB-	denotes	)
T8697	2980-2982	,	denotes	,
T8698	2982-2983	NN	denotes	n
T8699	2986-2987	CD	denotes	6
T8700	2984-2985	SYM	denotes	=
T8701	2988-2989	-LRB-	denotes	(
T8702	2996-2998	NN	denotes	KO
T8703	2989-2995	NN	denotes	XpdTTD
T8704	2995-2996	HYPH	denotes	/
T8705	2998-2999	-RRB-	denotes	)
T8706	2999-3001	,	denotes	,
T8707	3001-3002	NN	denotes	n
T8708	3005-3006	CD	denotes	4
T8709	3003-3004	SYM	denotes	=
T8710	3007-3008	-LRB-	denotes	(
T8711	3015-3020	NN	denotes	†XPCS
T8712	3008-3014	NN	denotes	XpdTTD
T8713	3014-3015	HYPH	denotes	/
T8714	3021-3022	-RRB-	denotes	)
T8715	3022-3024	,	denotes	,
T8716	3024-3025	NN	denotes	n
T8717	3028-3029	CD	denotes	2
T8718	3026-3027	SYM	denotes	=
T8719	3030-3031	-LRB-	denotes	(
T8720	3038-3041	NN	denotes	†XP
T8721	3031-3037	NN	denotes	XpdTTD
T8722	3037-3038	HYPH	denotes	/
T8723	3042-3043	-RRB-	denotes	)
T8724	3043-3044	:	denotes	;
T8725	3045-3046	CD	denotes	1
T8726	3047-3048	CD	denotes	2
T8727	3046-3047	SYM	denotes	–
T8728	3054-3059	NNS	denotes	lines
T8729	3049-3053	NN	denotes	cell
T8730	3060-3063	IN	denotes	per
T8731	3064-3072	NN	denotes	genotype
T8732	3073-3077	VBD	denotes	were
T8733	3087-3089	IN	denotes	in
T8734	3090-3094	DT	denotes	each
T8735	3095-3105	NN	denotes	experiment
T8736	3105-3106	.	denotes	.
T8737	3106-3226	sentence	denotes	The asterisk indicates significant difference with XpdTTD/TTD; crosses indicate significant differences with XpdTTD/KO.
T8738	3107-3110	DT	denotes	The
T8739	3111-3119	NN	denotes	asterisk
T8740	3120-3129	VBZ	denotes	indicates
T8741	3178-3186	VBP	denotes	indicate
T8742	3130-3141	JJ	denotes	significant
T8743	3142-3152	NN	denotes	difference
T8744	3153-3157	IN	denotes	with
T8745	3158-3164	NN	denotes	XpdTTD
T8746	3165-3168	NN	denotes	TTD
T8747	3164-3165	HYPH	denotes	/
T8748	3168-3169	:	denotes	;
T8749	3170-3177	NNS	denotes	crosses
T8750	3187-3198	JJ	denotes	significant
T8751	3199-3210	NNS	denotes	differences
T8752	3211-3215	IN	denotes	with
T8753	3216-3222	NN	denotes	XpdTTD
T8754	3223-3225	NN	denotes	KO
T8755	3222-3223	HYPH	denotes	/
T8756	3225-3226	.	denotes	.
T8757	3226-3303	sentence	denotes	(C) UV-RRS, a measure of transcription-coupled repair of UV-induced lesions.
T8758	3227-3228	-LRB-	denotes	(
T8759	3228-3229	LS	denotes	C
T8760	3234-3237	NN	denotes	RRS
T8761	3229-3230	-RRB-	denotes	)
T8762	3231-3233	NN	denotes	UV
T8763	3233-3234	HYPH	denotes	-
T8764	3237-3239	,	denotes	,
T8765	3239-3240	DT	denotes	a
T8766	3241-3248	NN	denotes	measure
T8767	3249-3251	IN	denotes	of
T8768	3252-3265	NN	denotes	transcription
T8769	3266-3273	VBN	denotes	coupled
T8770	3265-3266	HYPH	denotes	-
T8771	3274-3280	NN	denotes	repair
T8772	3281-3283	IN	denotes	of
T8773	3284-3286	NN	denotes	UV
T8774	3287-3294	VBN	denotes	induced
T8775	3286-3287	HYPH	denotes	-
T8776	3295-3302	NNS	denotes	lesions
T8777	3302-3303	.	denotes	.
T8778	3303-3471	sentence	denotes	Number of experiments: n = 7 (XpdTTD/TTD), n = 2 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8779	3304-3310	NN	denotes	Number
T8780	3443-3451	VBN	denotes	included
T8781	3311-3313	IN	denotes	of
T8782	3314-3325	NNS	denotes	experiments
T8783	3325-3327	:	denotes	:
T8784	3327-3328	NN	denotes	n
T8785	3331-3332	CD	denotes	7
T8786	3329-3330	SYM	denotes	=
T8787	3333-3334	-LRB-	denotes	(
T8788	3341-3344	NN	denotes	TTD
T8789	3334-3340	NN	denotes	XpdTTD
T8790	3340-3341	HYPH	denotes	/
T8791	3344-3345	-RRB-	denotes	)
T8792	3345-3347	,	denotes	,
T8793	3347-3348	NN	denotes	n
T8794	3351-3352	CD	denotes	2
T8795	3349-3350	SYM	denotes	=
T8796	3353-3354	-LRB-	denotes	(
T8797	3361-3363	NN	denotes	KO
T8798	3354-3360	NN	denotes	XpdTTD
T8799	3360-3361	HYPH	denotes	/
T8800	3363-3364	-RRB-	denotes	)
T8801	3364-3366	,	denotes	,
T8802	3366-3367	NN	denotes	n
T8803	3370-3371	CD	denotes	4
T8804	3368-3369	SYM	denotes	=
T8805	3372-3373	-LRB-	denotes	(
T8806	3380-3385	NN	denotes	†XPCS
T8807	3373-3379	NN	denotes	XpdTTD
T8808	3379-3380	HYPH	denotes	/
T8809	3386-3387	-RRB-	denotes	)
T8810	3387-3389	,	denotes	,
T8811	3389-3390	NN	denotes	n
T8812	3393-3394	CD	denotes	2
T8813	3391-3392	SYM	denotes	=
T8814	3395-3396	-LRB-	denotes	(
T8815	3403-3406	NN	denotes	†XP
T8816	3396-3402	NN	denotes	XpdTTD
T8817	3402-3403	HYPH	denotes	/
T8818	3407-3408	-RRB-	denotes	)
T8819	3408-3409	:	denotes	;
T8820	3410-3411	CD	denotes	1
T8821	3412-3413	CD	denotes	2
T8822	3411-3412	SYM	denotes	–
T8823	3419-3424	NNS	denotes	lines
T8824	3414-3418	NN	denotes	cell
T8825	3425-3428	IN	denotes	per
T8826	3429-3437	NN	denotes	genotype
T8827	3438-3442	VBD	denotes	were
T8828	3452-3454	IN	denotes	in
T8829	3455-3459	DT	denotes	each
T8830	3460-3470	NN	denotes	experiment
T8831	3470-3471	.	denotes	.
T8832	3471-3578	sentence	denotes	(D) Incision/excision activity of combinations of altered TFIIH complexes in a reconstituted NER reaction.
T8833	3472-3473	-LRB-	denotes	(
T8834	3473-3474	LS	denotes	D
T8835	3494-3502	NN	denotes	activity
T8836	3474-3475	-RRB-	denotes	)
T8837	3476-3484	NN	denotes	Incision
T8838	3485-3493	NN	denotes	excision
T8839	3484-3485	HYPH	denotes	/
T8840	3503-3505	IN	denotes	of
T8841	3506-3518	NNS	denotes	combinations
T8842	3519-3521	IN	denotes	of
T8843	3522-3529	VBN	denotes	altered
T8844	3536-3545	NNS	denotes	complexes
T8845	3530-3535	NN	denotes	TFIIH
T8846	3546-3548	IN	denotes	in
T8847	3549-3550	DT	denotes	a
T8848	3569-3577	NN	denotes	reaction
T8849	3551-3564	VBN	denotes	reconstituted
T8850	3565-3568	NN	denotes	NER
T8851	3577-3578	.	denotes	.
T8852	3578-3832	sentence	denotes	Equal amounts of single or mixed populations of recombinant TFIIHs (containing XPD, XPB, p62, p52, His-p44, Flag-p34, cdk7, cyclin H, Mat1, and p8) were mixed with recombinant XPG, XPF/ERCC1, XPC/hHR23B, RPA, and a radiolabelled synthetic NER substrate.
T8853	3579-3584	JJ	denotes	Equal
T8854	3585-3592	NNS	denotes	amounts
T8855	3732-3737	VBN	denotes	mixed
T8856	3593-3595	IN	denotes	of
T8857	3596-3602	JJ	denotes	single
T8858	3612-3623	NNS	denotes	populations
T8859	3603-3605	CC	denotes	or
T8860	3606-3611	JJ	denotes	mixed
T8861	3624-3626	IN	denotes	of
T8862	3627-3638	JJ	denotes	recombinant
T8863	3639-3645	NNS	denotes	TFIIHs
T8864	3646-3647	-LRB-	denotes	(
T8865	3647-3657	VBG	denotes	containing
T8866	3658-3661	NN	denotes	XPD
T8867	3661-3663	,	denotes	,
T8868	3663-3666	NN	denotes	XPB
T8869	3666-3668	,	denotes	,
T8870	3668-3671	NN	denotes	p62
T8871	3671-3673	,	denotes	,
T8872	3673-3676	NN	denotes	p52
T8873	3676-3678	,	denotes	,
T8874	3678-3681	NN	denotes	His
T8875	3682-3685	NN	denotes	p44
T8876	3681-3682	HYPH	denotes	-
T8877	3685-3687	,	denotes	,
T8878	3687-3691	NN	denotes	Flag
T8879	3692-3695	NN	denotes	p34
T8880	3691-3692	HYPH	denotes	-
T8881	3695-3697	,	denotes	,
T8882	3697-3701	NN	denotes	cdk7
T8883	3701-3703	,	denotes	,
T8884	3703-3709	NN	denotes	cyclin
T8885	3710-3711	NN	denotes	H
T8886	3711-3713	,	denotes	,
T8887	3713-3717	NN	denotes	Mat1
T8888	3717-3719	,	denotes	,
T8889	3719-3722	CC	denotes	and
T8890	3723-3725	NN	denotes	p8
T8891	3725-3726	-RRB-	denotes	)
T8892	3727-3731	VBD	denotes	were
T8893	3738-3742	IN	denotes	with
T8894	3743-3754	JJ	denotes	recombinant
T8895	3755-3758	NN	denotes	XPG
T8896	3758-3760	,	denotes	,
T8897	3760-3763	NN	denotes	XPF
T8898	3764-3769	NN	denotes	ERCC1
T8899	3763-3764	HYPH	denotes	/
T8900	3769-3771	,	denotes	,
T8901	3771-3774	NN	denotes	XPC
T8902	3775-3781	NN	denotes	hHR23B
T8903	3774-3775	HYPH	denotes	/
T8904	3781-3783	,	denotes	,
T8905	3783-3786	NN	denotes	RPA
T8906	3786-3788	,	denotes	,
T8907	3788-3791	CC	denotes	and
T8908	3792-3793	DT	denotes	a
T8909	3822-3831	NN	denotes	substrate
T8910	3794-3807	VBN	denotes	radiolabelled
T8911	3808-3817	JJ	denotes	synthetic
T8912	3818-3821	NN	denotes	NER
T8913	3831-3832	.	denotes	.
T8914	3832-3975	sentence	denotes	The excision products (26–34 nucleotides in length) were visualised at nucleotide resolution on a denaturing polyacrylamide gel as indicated .
T8915	3833-3836	DT	denotes	The
T8916	3846-3854	NNS	denotes	products
T8917	3837-3845	NN	denotes	excision
T8918	3890-3900	VBN	denotes	visualised
T8919	3855-3856	-LRB-	denotes	(
T8920	3862-3873	NNS	denotes	nucleotides
T8921	3856-3858	CD	denotes	26
T8922	3859-3861	CD	denotes	34
T8923	3858-3859	SYM	denotes	–
T8924	3874-3876	IN	denotes	in
T8925	3877-3883	NN	denotes	length
T8926	3883-3884	-RRB-	denotes	)
T8927	3885-3889	VBD	denotes	were
T8928	3901-3903	IN	denotes	at
T8929	3904-3914	NN	denotes	nucleotide
T8930	3915-3925	NN	denotes	resolution
T8931	3926-3928	IN	denotes	on
T8932	3929-3930	DT	denotes	a
T8933	3957-3960	NN	denotes	gel
T8934	3931-3941	VBG	denotes	denaturing
T8935	3942-3956	NN	denotes	polyacrylamide
T8936	3961-3963	IN	denotes	as
T8937	3964-3973	VBN	denotes	indicated
T8938	3974-3975	.	denotes	.
T8939	3975-4126	sentence	denotes	Note the weak activity corresponding to each single and combined TFIIH complex (lanes 3–8) relative to the wt (lane 1) and negative controls (lane 2).
T8940	3976-3980	VB	denotes	Note
T8941	3981-3984	DT	denotes	the
T8942	3990-3998	NN	denotes	activity
T8943	3985-3989	JJ	denotes	weak
T8944	3999-4012	VBG	denotes	corresponding
T8945	4013-4015	IN	denotes	to
T8946	4016-4020	DT	denotes	each
T8947	4047-4054	NN	denotes	complex
T8948	4021-4027	JJ	denotes	single
T8949	4028-4031	CC	denotes	and
T8950	4032-4040	VBN	denotes	combined
T8951	4041-4046	NN	denotes	TFIIH
T8952	4055-4056	-LRB-	denotes	(
T8953	4062-4063	CD	denotes	3
T8954	4056-4061	NNS	denotes	lanes
T8955	4063-4064	SYM	denotes	–
T8956	4064-4065	CD	denotes	8
T8957	4065-4066	-RRB-	denotes	)
T8958	4067-4075	JJ	denotes	relative
T8959	4076-4078	IN	denotes	to
T8960	4079-4082	DT	denotes	the
T8961	4083-4085	NN	denotes	wt
T8962	4086-4087	-LRB-	denotes	(
T8963	4087-4091	NN	denotes	lane
T8964	4092-4093	CD	denotes	1
T8965	4093-4094	-RRB-	denotes	)
T8966	4095-4098	CC	denotes	and
T8967	4099-4107	JJ	denotes	negative
T8968	4108-4116	NNS	denotes	controls
T8969	4117-4118	-LRB-	denotes	(
T8970	4118-4122	NN	denotes	lane
T8971	4123-4124	CD	denotes	2
T8972	4124-4125	-RRB-	denotes	)
T8973	4125-4126	.	denotes	.
T8974	4126-4339	sentence	denotes	(E) Xpd dose-dependent reduction of TFIIH in homozygous XpdTTD/TTD, hemizygous XpdTTD/KO, and compound heterozygous XpdTTD/†XPCS and XpdTTD/†XP cells by comparative immunofluorescence of the p62 subunit of TFIIH.
T8975	4127-4128	-LRB-	denotes	(
T8976	4128-4129	LS	denotes	E
T8977	4150-4159	NN	denotes	reduction
T8978	4129-4130	-RRB-	denotes	)
T8979	4131-4134	NN	denotes	Xpd
T8980	4135-4139	NN	denotes	dose
T8981	4140-4149	JJ	denotes	dependent
T8982	4139-4140	HYPH	denotes	-
T8983	4160-4162	IN	denotes	of
T8984	4163-4168	NN	denotes	TFIIH
T8985	4169-4171	IN	denotes	in
T8986	4172-4182	JJ	denotes	homozygous
T8987	4190-4193	NN	denotes	TTD
T8988	4183-4189	NN	denotes	XpdTTD
T8989	4189-4190	HYPH	denotes	/
T8990	4271-4276	NNS	denotes	cells
T8991	4193-4195	,	denotes	,
T8992	4195-4205	JJ	denotes	hemizygous
T8993	4213-4215	NN	denotes	KO
T8994	4206-4212	NN	denotes	XpdTTD
T8995	4212-4213	HYPH	denotes	/
T8996	4215-4217	,	denotes	,
T8997	4217-4220	CC	denotes	and
T8998	4221-4229	NN	denotes	compound
T8999	4250-4255	NN	denotes	†XPCS
T9000	4230-4242	JJ	denotes	heterozygous
T9001	4243-4249	NN	denotes	XpdTTD
T9002	4249-4250	HYPH	denotes	/
T9003	4256-4259	CC	denotes	and
T9004	4260-4266	NN	denotes	XpdTTD
T9005	4267-4270	NN	denotes	†XP
T9006	4266-4267	HYPH	denotes	/
T9007	4277-4279	IN	denotes	by
T9008	4280-4291	JJ	denotes	comparative
T9009	4292-4310	NN	denotes	immunofluorescence
T9010	4311-4313	IN	denotes	of
T9011	4314-4317	DT	denotes	the
T9012	4322-4329	NN	denotes	subunit
T9013	4318-4321	NN	denotes	p62
T9014	4330-4332	IN	denotes	of
T9015	4333-4338	NN	denotes	TFIIH
T9016	4338-4339	.	denotes	.
T9017	4339-4757	sentence	denotes	Roman numerals represent different microscopic slides and Arabic numerals different cell lines labelled as follows: (I) wt cells (1) labelled with 2-μm beads, XpdTTD/TTD cells (2) with 0.79-μm beads, and XpdTTD/KO cells (3) with no beads; (II) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XPCS cells (4) with no beads; and (III) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XP cells (5) with no beads.
T9018	4340-4345	JJ	denotes	Roman
T9019	4346-4354	NNS	denotes	numerals
T9020	4355-4364	VBP	denotes	represent
T9021	4365-4374	JJ	denotes	different
T9022	4387-4393	NNS	denotes	slides
T9023	4375-4386	JJ	denotes	microscopic
T9024	4394-4397	CC	denotes	and
T9025	4398-4404	JJ	denotes	Arabic
T9026	4405-4413	NNS	denotes	numerals
T9027	4429-4434	NNS	denotes	lines
T9028	4414-4423	JJ	denotes	different
T9029	4424-4428	NN	denotes	cell
T9030	4435-4443	VBN	denotes	labelled
T9031	4444-4446	IN	denotes	as
T9032	4447-4454	VBZ	denotes	follows
T9033	4454-4456	:	denotes	:
T9034	4456-4457	-LRB-	denotes	(
T9035	4457-4458	LS	denotes	I
T9036	4463-4468	NNS	denotes	cells
T9037	4458-4459	-RRB-	denotes	)
T9038	4460-4462	NN	denotes	wt
T9039	4469-4470	-LRB-	denotes	(
T9040	4470-4471	CD	denotes	1
T9041	4471-4472	-RRB-	denotes	)
T9042	4473-4481	VBN	denotes	labelled
T9043	4482-4486	IN	denotes	with
T9044	4487-4488	CD	denotes	2
T9045	4489-4491	NN	denotes	μm
T9046	4488-4489	HYPH	denotes	-
T9047	4492-4497	NNS	denotes	beads
T9048	4497-4499	,	denotes	,
T9049	4499-4505	NN	denotes	XpdTTD
T9050	4506-4509	NN	denotes	TTD
T9051	4505-4506	HYPH	denotes	/
T9052	4510-4515	NNS	denotes	cells
T9053	4516-4517	-LRB-	denotes	(
T9054	4517-4518	CD	denotes	2
T9055	4518-4519	-RRB-	denotes	)
T9056	4520-4524	IN	denotes	with
T9057	4525-4529	CD	denotes	0.79
T9058	4530-4532	NN	denotes	μm
T9059	4529-4530	HYPH	denotes	-
T9060	4533-4538	NNS	denotes	beads
T9061	4538-4540	,	denotes	,
T9062	4540-4543	CC	denotes	and
T9063	4544-4550	NN	denotes	XpdTTD
T9064	4551-4553	NN	denotes	KO
T9065	4550-4551	HYPH	denotes	/
T9066	4554-4559	NNS	denotes	cells
T9067	4560-4561	-LRB-	denotes	(
T9068	4561-4562	CD	denotes	3
T9069	4562-4563	-RRB-	denotes	)
T9070	4564-4568	IN	denotes	with
T9071	4569-4571	DT	denotes	no
T9072	4572-4577	NNS	denotes	beads
T9073	4577-4578	:	denotes	;
T9074	4579-4580	-LRB-	denotes	(
T9075	4580-4582	LS	denotes	II
T9076	4587-4592	NNS	denotes	cells
T9077	4582-4583	-RRB-	denotes	)
T9078	4584-4586	NN	denotes	wt
T9079	4593-4594	-LRB-	denotes	(
T9080	4594-4595	CD	denotes	1
T9081	4595-4596	-RRB-	denotes	)
T9082	4597-4605	VBN	denotes	labelled
T9083	4606-4610	IN	denotes	with
T9084	4611-4615	CD	denotes	0.79
T9085	4616-4618	NN	denotes	μm
T9086	4615-4616	HYPH	denotes	-
T9087	4619-4624	NNS	denotes	beads
T9088	4625-4628	CC	denotes	and
T9089	4629-4635	NN	denotes	XpdTTD
T9090	4636-4641	NN	denotes	†XPCS
T9091	4635-4636	HYPH	denotes	/
T9092	4642-4647	NNS	denotes	cells
T9093	4648-4649	-LRB-	denotes	(
T9094	4649-4650	CD	denotes	4
T9095	4650-4651	-RRB-	denotes	)
T9096	4652-4656	IN	denotes	with
T9097	4657-4659	DT	denotes	no
T9098	4660-4665	NNS	denotes	beads
T9099	4665-4666	:	denotes	;
T9100	4667-4670	CC	denotes	and
T9101	4671-4672	-LRB-	denotes	(
T9102	4672-4675	LS	denotes	III
T9103	4680-4685	NNS	denotes	cells
T9104	4675-4676	-RRB-	denotes	)
T9105	4677-4679	NN	denotes	wt
T9106	4686-4687	-LRB-	denotes	(
T9107	4687-4688	CD	denotes	1
T9108	4688-4689	-RRB-	denotes	)
T9109	4690-4698	VBN	denotes	labelled
T9110	4699-4703	IN	denotes	with
T9111	4704-4708	CD	denotes	0.79
T9112	4709-4711	NN	denotes	μm
T9113	4708-4709	HYPH	denotes	-
T9114	4712-4717	NNS	denotes	beads
T9115	4718-4721	CC	denotes	and
T9116	4722-4728	NN	denotes	XpdTTD
T9117	4729-4732	NN	denotes	†XP
T9118	4728-4729	HYPH	denotes	/
T9119	4733-4738	NNS	denotes	cells
T9120	4739-4740	-LRB-	denotes	(
T9121	4740-4741	CD	denotes	5
T9122	4741-4742	-RRB-	denotes	)
T9123	4743-4747	IN	denotes	with
T9124	4748-4750	DT	denotes	no
T9125	4751-4756	NNS	denotes	beads
T9126	4756-4757	.	denotes	.
T9127	4757-4876	sentence	denotes	(F) Quantification of immunofluorescent signal from at least 50 nuclei per cell line and 2–6 experiments per genotype.
T9128	4758-4759	-LRB-	denotes	(
T9129	4759-4760	LS	denotes	F
T9130	4762-4776	NN	denotes	Quantification
T9131	4760-4761	-RRB-	denotes	)
T9132	4777-4779	IN	denotes	of
T9133	4780-4797	JJ	denotes	immunofluorescent
T9134	4798-4804	NN	denotes	signal
T9135	4805-4809	IN	denotes	from
T9136	4810-4812	RB	denotes	at
T9137	4819-4821	CD	denotes	50
T9138	4813-4818	RBS	denotes	least
T9139	4822-4828	NNS	denotes	nuclei
T9140	4829-4832	IN	denotes	per
T9141	4833-4837	NN	denotes	cell
T9142	4838-4842	NN	denotes	line
T9143	4843-4846	CC	denotes	and
T9144	4847-4848	CD	denotes	2
T9145	4849-4850	CD	denotes	6
T9146	4848-4849	SYM	denotes	–
T9147	4851-4862	NNS	denotes	experiments
T9148	4863-4866	IN	denotes	per
T9149	4867-4875	NN	denotes	genotype
T9150	4875-4876	.	denotes	.
T9151	4876-4987	sentence	denotes	Bars representing cells analysed on the same microscopic slide are depicted side by side, with wt set at 100%.
T9152	4877-4881	NNS	denotes	Bars
T9153	4944-4952	VBN	denotes	depicted
T9154	4882-4894	VBG	denotes	representing
T9155	4895-4900	NNS	denotes	cells
T9156	4901-4909	VBN	denotes	analysed
T9157	4910-4912	IN	denotes	on
T9158	4913-4916	DT	denotes	the
T9159	4934-4939	NN	denotes	slide
T9160	4917-4921	JJ	denotes	same
T9161	4922-4933	JJ	denotes	microscopic
T9162	4940-4943	VBP	denotes	are
T9163	4953-4957	NN	denotes	side
T9164	4958-4960	IN	denotes	by
T9165	4961-4965	NN	denotes	side
T9166	4965-4967	,	denotes	,
T9167	4967-4971	IN	denotes	with
T9168	4972-4974	NN	denotes	wt
T9169	4975-4978	VBN	denotes	set
T9170	4979-4981	IN	denotes	at
T9171	4982-4985	CD	denotes	100
T9172	4985-4986	NN	denotes	%
T9173	4986-4987	.	denotes	.
T9174	4987-5142	sentence	denotes	The p-value indicates minimum significant difference between wt and the indicated cell lines analysed on the same microscopic slide within one experiment.
T9175	4988-4991	DT	denotes	The
T9176	4994-4999	NN	denotes	value
T9177	4992-4993	NN	denotes	p
T9178	4993-4994	HYPH	denotes	-
T9179	5000-5009	VBZ	denotes	indicates
T9180	5010-5017	JJ	denotes	minimum
T9181	5030-5040	NN	denotes	difference
T9182	5018-5029	JJ	denotes	significant
T9183	5041-5048	IN	denotes	between
T9184	5049-5051	NN	denotes	wt
T9185	5052-5055	CC	denotes	and
T9186	5056-5059	DT	denotes	the
T9187	5075-5080	NNS	denotes	lines
T9188	5060-5069	VBN	denotes	indicated
T9189	5070-5074	NN	denotes	cell
T9190	5081-5089	VBN	denotes	analysed
T9191	5090-5092	IN	denotes	on
T9192	5093-5096	DT	denotes	the
T9193	5114-5119	NN	denotes	slide
T9194	5097-5101	JJ	denotes	same
T9195	5102-5113	JJ	denotes	microscopic
T9196	5120-5126	IN	denotes	within
T9197	5127-5130	CD	denotes	one
T9198	5131-5141	NN	denotes	experiment
T9199	5141-5142	.	denotes	.
T3736	2099-2107	RB	denotes	together
T3737	2107-2109	,	denotes	,
T3738	2109-2114	DT	denotes	these
T3739	2115-2119	NNS	denotes	data
T3740	2124-2134	JJ	denotes	consistent
T3741	2135-2139	IN	denotes	with
T3742	2140-2152	JJ	denotes	interallelic
T3743	2153-2168	NN	denotes	complementation
T3744	2169-2171	IN	denotes	of
T3745	2172-2174	NN	denotes	UV
T3746	2175-2186	NN	denotes	sensitivity
T3747	2187-2189	IN	denotes	in
T3748	2190-2195	NNS	denotes	cells
T3749	2196-2199	CC	denotes	but
T3750	2200-2210	VBP	denotes	underscore
T3751	2211-2214	DT	denotes	the
T3752	2215-2219	NN	denotes	lack
T3753	2220-2222	IN	denotes	of
T3754	2223-2226	DT	denotes	any
T3755	2227-2238	NN	denotes	correlation
T3756	2239-2246	IN	denotes	between
T3757	2247-2249	NN	denotes	UV
T3758	2250-2257	VBN	denotes	related
T3759	2249-2250	HYPH	denotes	-
T3760	2265-2280	NNS	denotes	characteristics
T3761	2258-2264	NN	denotes	repair
T3762	2281-2284	CC	denotes	and
T3763	2285-2288	NN	denotes	TTD
T3764	2299-2309	NNS	denotes	phenotypes
T3765	2289-2298	NN	denotes	progeroid
T3766	2310-2312	IN	denotes	in
T3767	2313-2319	NN	denotes	animal
T3768	2320-2326	NNS	denotes	models
T3769	2326-2327	.	denotes	.
T3770	2327-2328	sentence	denotes
T3771	5143-5152	sentence	denotes	Next we a
T3772	5143-5145	NN	denotes	Ne
T3773	5145-5147	NNS	denotes	xt
T3774	5147-5148	:	denotes
T3775	5148-5150	VBD	denotes	we
T3776	5151-5152	DT	denotes	a
T3777	5152-5162	sentence	denotes	sked wheth
T3778	5152-5154	NN	denotes	sk
T3779	5154-5155	VBZ	denotes	e
T3780	5160-5161	VBP	denotes	t
T3781	5155-5156	NN	denotes	d
T3782	5157-5159	IN	denotes	wh
T3783	5159-5160	NNS	denotes	e
T3784	5161-5162	IN	denotes	h
T3785	5162-5166	sentence	denotes	er t
T3786	5162-5164	NN	denotes	er
T3787	5165-5166	NN	denotes	t
T3788	5166-5168	sentence	denotes	he
T3789	5166-5167	DT	denotes	h
T3790	5167-5168	NN	denotes	e
T3791	5168-5169	sentence	denotes
T3792	5169-5172	sentence	denotes	Xpd
T3793	5169-5170	NN	denotes	X
T3794	5170-5171	NN	denotes	p
T3795	5171-5172	NN	denotes	d
T3796	5172-5191	sentence	denotes	†XPCS and Xpd†XP al
T3797	5172-5177	NN	denotes	†XPCS
T3798	5178-5181	CC	denotes	and
T3799	5182-5185	NN	denotes	Xpd
T3800	5185-5188	NN	denotes	†XP
T3801	5189-5190	JJ	denotes	a
T3802	5190-5191	NN	denotes	l
T3803	5191-5209	sentence	denotes	leles, despite dec
T3804	5191-5192	NNS	denotes	l
T3805	5192-5193	VBP	denotes	e
T3806	5193-5196	NNS	denotes	les
T3807	5196-5198	,	denotes	,
T3808	5198-5199	NN	denotes	d
T3809	5199-5201	NNS	denotes	es
T3810	5201-5202	NN	denotes	p
T3811	5202-5204	IN	denotes	it
T3812	5204-5205	NNS	denotes	e
T3813	5206-5207	VBN	denotes	d
T3814	5207-5208	NNS	denotes	e
T3815	5208-5209	NNS	denotes	c
T3816	5209-5217	sentence	denotes	reased m
T3817	5209-5211	JJ	denotes	re
T3818	5211-5212	NN	denotes	a
T3819	5212-5213	RBS	denotes	s
T3820	5213-5214	NNS	denotes	e
T3821	5214-5215	CC	denotes	d
T3822	5216-5217	NNS	denotes	m
T3823	5217-5350	sentence	denotes	RNA levels, ameliorated TTD symptoms by increasing overall TFIIH levels in compound heterozygous XpdTTD/ †XPCS and XpdTTD/ †XP cells.
T3824	5229-5240	VBN	denotes	ameliorated
T3825	5221-5227	NNS	denotes	levels
T3826	5217-5220	NN	denotes	RNA
T3827	5227-5229	,	denotes	,
T3828	5241-5244	NN	denotes	TTD
T3829	5245-5253	NNS	denotes	symptoms
T3830	5254-5256	IN	denotes	by
T3831	5257-5267	VBG	denotes	increasing
T3832	5282-5288	NNS	denotes	levels
T3833	5268-5275	JJ	denotes	overall
T3834	5276-5281	NN	denotes	TFIIH
T3835	5289-5291	IN	denotes	in
T3836	5292-5300	NN	denotes	compound
T3837	5344-5349	NNS	denotes	cells
T3838	5301-5313	JJ	denotes	heterozygous
T3839	5314-5320	NN	denotes	XpdTTD
T3840	5321-5327	NN	denotes	†XPCS
T3841	5320-5321	HYPH	denotes	/
T3842	5328-5331	CC	denotes	and
T3843	5332-5338	NN	denotes	XpdTTD
T3844	5339-5343	NN	denotes	†XP
T3845	5338-5339	HYPH	denotes	/
T3846	5349-5350	.	denotes	.
T3847	5350-5572	sentence	denotes	Previously, using comparative immunohistochemistry, we and others have shown an up to 70% reduction of TFIIH levels in primary fibroblasts from patients with TTD compared with wt controls due to reduced stability [16,17].
T3848	5351-5361	RB	denotes	Previously
T3849	5422-5427	VBN	denotes	shown
T3850	5361-5363	,	denotes	,
T3851	5363-5368	VBG	denotes	using
T3852	5369-5380	JJ	denotes	comparative
T3853	5381-5401	NN	denotes	immunohistochemistry
T3854	5401-5403	,	denotes	,
T3855	5403-5405	PRP	denotes	we
T3856	5406-5409	CC	denotes	and
T3857	5410-5416	NNS	denotes	others
T3858	5417-5421	VBP	denotes	have
T3859	5428-5430	DT	denotes	an
T3860	5441-5450	NN	denotes	reduction
T3861	5431-5433	IN	denotes	up
T3862	5437-5439	CD	denotes	70
T3863	5434-5436	IN	denotes	to
T3864	5439-5440	NN	denotes	%
T3865	5451-5453	IN	denotes	of
T3866	5454-5459	NN	denotes	TFIIH
T3867	5460-5466	NNS	denotes	levels
T3868	5467-5469	IN	denotes	in
T3869	5470-5477	JJ	denotes	primary
T3870	5478-5489	NNS	denotes	fibroblasts
T3871	5490-5494	IN	denotes	from
T4084	6568-6574	JJ	denotes	normal
T4085	6574-6575	.	denotes	.
R2083	T3312	T3313	amod	Molecular,Mechanisms
R2084	T3314	T3313	prep	of,Mechanisms
R2085	T3315	T3316	amod	Biallelic,Effects
R2086	T3316	T3314	pobj	Effects,of
R2087	T3318	T3319	nsubj	We,turned
R2088	T3320	T3319	advmod	next,turned
R2089	T3321	T3319	prep	to,turned
R2090	T3322	T3323	npadvmod	UV,based
R2091	T3323	T3325	amod	based,assays
R2092	T3324	T3323	punct	-,based
R2093	T3325	T3321	pobj	assays,to
R2094	T3326	T3325	amod	cellular,assays
R2095	T3327	T3325	prep	including,assays
R2096	T3328	T3329	amod	unscheduled,synthesis
R2097	T3329	T3327	pobj	synthesis,including
R2098	T3330	T3329	compound	DNA,synthesis
R2099	T3331	T3329	prep	after,synthesis
R2100	T3332	T3333	compound	UV,irradiation
R2101	T3333	T3331	pobj	irradiation,after
R2102	T3334	T3335	punct	(,UDS
R2103	T3335	T3329	parataxis	UDS,synthesis
R2104	T3336	T3335	compound	UV,UDS
R2105	T3337	T3335	punct	-,UDS
R2106	T3338	T3335	punct	),UDS
R2107	T3339	T3329	punct	", ",synthesis
R2108	T3340	T3329	conj	recovery,synthesis
R2109	T3341	T3340	prep	of,recovery
R2110	T3342	T3343	compound	RNA,synthesis
R2111	T3343	T3341	pobj	synthesis,of
R2112	T3344	T3340	prep	after,recovery
R2113	T3345	T3346	compound	UV,irradiation
R2114	T3346	T3344	pobj	irradiation,after
R2115	T3347	T3348	punct	(,RRS
R2116	T3348	T3340	parataxis	RRS,recovery
R2117	T3349	T3348	compound	UV,RRS
R2118	T3350	T3348	punct	-,RRS
R2119	T3351	T3348	punct	),RRS
R2120	T3352	T3340	punct	", ",recovery
R2121	T3353	T3340	cc	and,recovery
R2122	T3354	T3355	compound	UV,survival
R2123	T3355	T3340	conj	survival,recovery
R2124	T3356	T3329	punct	", ",synthesis
R2125	T3357	T3358	dep	which,report
R2126	T3358	T3329	relcl	report,synthesis
R2127	T3359	T3358	prep	on,report
R2128	T3360	T3361	det	the,subpathways
R2129	T3361	T3359	pobj	subpathways,on
R2130	T3362	T3361	compound	NER,subpathways
R2131	T3363	T3364	punct	(,NER
R2132	T3364	T3361	parataxis	NER,subpathways
R2133	T3365	T3364	amod	global,NER
R2134	T3366	T3364	compound	genome,NER
R2135	T3367	T3364	cc	and,NER
R2136	T3368	T3369	npadvmod	transcription,coupled
R2137	T3369	T3371	amod	coupled,NER
R2138	T3370	T3369	punct	-,coupled
R2139	T3371	T3364	conj	NER,NER
R2140	T3372	T3364	punct	),NER
R2141	T3373	T3361	cc	and,subpathways
R2142	T3374	T3375	amod	total,NER
R2143	T3375	T3361	conj	NER,subpathways
R2144	T3376	T3358	punct	", ",report
R2145	T3377	T3358	advmod	respectively,report
R2146	T3378	T3319	punct	.,turned
R2147	T3380	T3381	prep	In,improved
R2148	T3382	T3380	pobj	none,In
R2149	T3383	T3382	prep	of,none
R2150	T3384	T3385	det	these,assays
R2151	T3385	T3383	pobj	assays,of
R2152	T3386	T3381	auxpass	was,improved
R2153	T3387	T3388	det	the,response
R2154	T3388	T3381	nsubjpass	response,improved
R2155	T3389	T3388	prep	to,response
R2156	T3390	T3389	pobj	UV,to
R2157	T3391	T3381	prep	in,improved
R2158	T3392	T3393	compound	compound,heterozygotes
R2159	T3393	T3391	pobj	heterozygotes,in
R2160	T3394	T3381	advcl	relative,improved
R2161	T3395	T3394	prep	to,relative
R2162	T3396	T3397	compound	TTD,homozygotes
R2163	T3397	T3395	pobj	homozygotes,to
R2164	T3398	T3399	punct	(,4A
R2165	T3399	T3381	parataxis	4A,improved
R2166	T3400	T3399	compound	Figure,4A
R2167	T3401	T3402	punct	–,4C
R2168	T3402	T3399	prep	4C,4A
R2169	T3403	T3399	punct	),4A
R2170	T3404	T3381	punct	.,improved
R2171	T3406	T3407	advmod	However,observed
R2172	T3408	T3407	punct	", ",observed
R2173	T3409	T3407	prep	unlike,observed
R2174	T3410	T3411	det	the,phenotypes
R2175	T3411	T3409	pobj	phenotypes,unlike
R2176	T3412	T3413	advmod	in,vivo
R2177	T3413	T3411	amod	vivo,phenotypes
R2178	T3414	T3411	compound	TTD,phenotypes
R2179	T3415	T3411	acl	described,phenotypes
R2180	T3416	T3415	advmod	above,described
R2181	T3417	T3411	punct	", ",phenotypes
R2182	T3418	T3419	prep	in,were
R2183	T3419	T3411	relcl	were,phenotypes
R2184	T3420	T3418	pobj	which,in
R2185	T3421	T3422	nmod	XpdTTD,TTD
R2186	T3422	T3424	nmod	TTD,animals
R2187	T3423	T3422	punct	/,TTD
R2188	T3424	T3419	nsubj	animals,were
R2189	T3425	T3422	cc	and,TTD
R2190	T3426	T3427	compound	XpdTTD,KO
R2191	T3427	T3422	conj	KO,TTD
R2192	T3428	T3427	punct	/,KO
R2193	T3429	T3419	acomp	indistinguishable,were
R2194	T3430	T3407	punct	", ",observed
R2195	T3431	T3432	compound	XpdTTD,effects
R2196	T3432	T3407	nsubjpass	effects,observed
R2197	T3433	T3432	compound	dosage,effects
R2198	T3434	T3407	auxpass	were,observed
R2199	T3435	T3407	prep	in,observed
R2200	T3436	T3437	compound	UV,survival
R2201	T3437	T3435	pobj	survival,in
R2202	T3438	T3437	punct	", ",survival
R2203	T3439	T3440	compound	UV,UDS
R2204	T3440	T3437	conj	UDS,survival
R2205	T3441	T3440	punct	-,UDS
R2206	T3442	T3440	punct	", ",UDS
R2207	T3443	T3440	cc	and,UDS
R2208	T3444	T3445	compound	UV,RRS
R2209	T3445	T3440	conj	RRS,UDS
R2210	T3446	T3445	punct	-,RRS
R2211	T3447	T3407	punct	", ",observed
R2212	T3448	T3407	advcl	indicating,observed
R2213	T3449	T3450	mark	that,correlate
R2214	T3450	T3448	ccomp	correlate,indicating
R2215	T3451	T3452	amod	cellular,parameters
R2216	T3452	T3450	nsubj	parameters,correlate
R2217	T3453	T3454	mark	as,measured
R2218	T3454	T3452	advcl	measured,parameters
R2219	T3455	T3454	prep	in,measured
R2220	T3456	T3455	pobj	fibroblasts,in
R2221	T3457	T3454	advmod	here,measured
R2222	T3458	T3450	aux	do,correlate
R2223	T3459	T3450	neg	not,correlate
R2224	T3460	T3450	advmod	always,correlate
R2225	T3461	T3450	prep	with,correlate
R2226	T3462	T3463	det	the,phenotype
R2227	T3463	T3461	pobj	phenotype,with
R2228	T3464	T3450	prep	at,correlate
R2229	T3465	T3466	det	the,level
R2230	T3466	T3464	pobj	level,at
R2231	T3467	T3466	prep	of,level
R2232	T3468	T3469	det	the,organism
R2233	T3469	T3467	pobj	organism,of
R2234	T3470	T3469	amod	intact,organism
R2235	T3471	T3407	punct	.,observed
R2236	T3473	T3474	nmod	XpdTTD,KO
R2237	T3474	T3476	nmod	KO,cells
R2238	T3475	T3474	punct	/,KO
R2239	T3476	T3478	nsubjpass	cells,used
R2240	T3477	T3476	amod	hemizygous,cells
R2241	T3479	T3478	auxpass	were,used
R2242	T3480	T3478	advmod	thus,used
R2243	T3481	T3478	prep	as,used
R2244	T3482	T3483	det	the,baseline
R2245	T3483	T3481	pobj	baseline,as
R2246	T3484	T3485	prep	on,compare
R2247	T3485	T3483	relcl	compare,baseline
R2248	T3486	T3484	pobj	which,on
R2249	T3487	T3485	aux	to,compare
R2250	T3488	T3489	det	the,activity
R2251	T3489	T3485	dobj	activity,compare
R2252	T3490	T3489	prep	of,activity
R2253	T3491	T3492	nmod	compound,cells
R2254	T3492	T3490	pobj	cells,of
R2255	T3493	T3492	amod	heterozygous,cells
R2256	T3494	T3478	punct	.,used
R2257	T3496	T3497	advcl	Relative,improved
R2258	T3498	T3496	prep	to,Relative
R2259	T3499	T3500	compound	XpdTTD,KO
R2260	T3500	T3502	compound	KO,cells
R2261	T3501	T3500	punct	/,KO
R2262	T3502	T3498	pobj	cells,to
R2263	T3503	T3502	compound	hemizygote,cells
R2264	T3504	T3497	punct	", ",improved
R2265	T3505	T3506	compound	UV,survival
R2266	T3506	T3497	nsubjpass	survival,improved
R2267	T3507	T3497	auxpass	was,improved
R2268	T3508	T3497	prep	by,improved
R2269	T3509	T3510	det	the,allele
R2270	T3510	T3508	pobj	allele,by
R2271	T3511	T3510	amod	homozygous,allele
R2272	T3512	T3510	amod	lethal,allele
R2273	T3513	T3510	compound	Xpd†XPCS,allele
R2274	T3514	T3510	prep	in,allele
R2275	T3515	T3516	nmod	XpdTTD,†XPCS
R2276	T3516	T3518	nmod	†XPCS,cells
R2277	T3517	T3516	punct	/,†XPCS
R2278	T3518	T3514	pobj	cells,in
R2279	T3519	T3518	nmod	compound,cells
R2280	T3520	T3518	amod	heterozygous,cells
R2281	T3521	T3508	cc	and,by
R2282	T3522	T3523	prep	to,by
R2283	T3523	T3508	conj	by,by
R2284	T3524	T3525	det	a,degree
R2285	T3525	T3522	pobj	degree,to
R2286	T3526	T3525	amod	lesser,degree
R2287	T3527	T3528	det	the,allele
R2288	T3528	T3523	pobj	allele,by
R2289	T3529	T3528	compound	Xpd†XP,allele
R2290	T3530	T3531	punct	(,4A
R2291	T3531	T3497	parataxis	4A,improved
R2292	T3532	T3531	compound	Figure,4A
R2293	T3533	T3531	punct	),4A
R2294	T3534	T3497	punct	.,improved
R2295	T3536	T3537	prep	Because,were
R2296	T3538	T3536	pcomp	of,Because
R2297	T3539	T3540	amod	embryonic,lethality
R2298	T3540	T3536	pobj	lethality,Because
R2299	T3541	T3539	cc	and,embryonic
R2300	T3542	T3539	conj	cellular,embryonic
R2301	T3543	T3537	punct	", ",were
R2302	T3544	T3537	nsubj	we,were
R2303	T3545	T3537	acomp	unable,were
R2304	T3546	T3547	aux	to,test
R2305	T3547	T3545	xcomp	test,unable
R2306	T3548	T3549	compound	UV,survival
R2307	T3549	T3547	dobj	survival,test
R2308	T3550	T3549	acl	associated,survival
R2309	T3551	T3550	advmod	exclusively,associated
R2310	T3552	T3550	prep	with,associated
R2311	T3553	T3554	det	the,alleles
R2312	T3554	T3552	pobj	alleles,with
R2313	T3555	T3554	nmod	Xpd†XPCS,alleles
R2314	T3556	T3555	cc	or,Xpd†XPCS
R2315	T3557	T3555	conj	Xpd†XP,Xpd†XPCS
R2316	T3558	T3537	punct	.,were
R2317	T3560	T3561	advmod	However,known
R2318	T3562	T3561	punct	", ",known
R2319	T3563	T3564	amod	homozygous,XPDXP
R2320	T3564	T3565	nmod	XPDXP,cells
R2321	T3565	T3561	nsubjpass	cells,known
R2322	T3566	T3567	punct	(,XPDR683W
R2323	T3567	T3564	parataxis	XPDR683W,XPDXP
R2324	T3568	T3567	punct	),XPDR683W
R2325	T3569	T3564	cc	and,XPDXP
R2326	T3570	T3571	amod	hemizygous,XPDXPCS
R2327	T3571	T3564	conj	XPDXPCS,XPDXP
R2328	T3572	T3573	punct	(,XPDG602D
R2329	T3573	T3571	parataxis	XPDG602D,XPDXPCS
R2330	T3574	T3573	punct	),XPDG602D
R2331	T3575	T3565	amod	human,cells
R2332	T3576	T3561	auxpass	are,known
R2333	T3577	T3578	aux	to,be
R2334	T3578	T3561	xcomp	be,known
R2335	T3579	T3580	advmod	highly,sensitive
R2336	T3580	T3578	acomp	sensitive,be
R2337	T3581	T3580	prep	to,sensitive
R2338	T3582	T3581	pobj	UV,to
R2339	T3583	T3584	punct	[,25
R2340	T3584	T3578	parataxis	25,be
R2341	T3585	T3584	nummod	19,25
R2342	T3586	T3584	punct	",",25
R2343	T3587	T3584	punct	],25
R2344	T3588	T3561	punct	", ",known
R2345	T3589	T3590	mark	as,are
R2346	T3590	T3561	advcl	are,known
R2347	T3591	T3590	nsubj	cells,are
R2348	T3592	T3591	prep	from,cells
R2349	T3593	T3594	det	a,model
R2350	T3594	T3592	pobj	model,from
R2351	T3595	T3594	amod	homozygous,model
R2352	T3596	T3594	amod	viable,model
R2353	T3597	T3598	nmod	XpdXPCS,XPCS
R2354	T3598	T3594	nmod	XPCS,model
R2355	T3599	T3598	punct	/,XPCS
R2356	T3600	T3601	punct	(,G602D
R2357	T3601	T3598	parataxis	G602D,XPCS
R2358	T3602	T3601	compound	XPDG602D,G602D
R2359	T3603	T3601	punct	/,G602D
R2360	T3604	T3601	punct	),G602D
R2361	T3605	T3594	compound	mouse,model
R2362	T3606	T3607	punct	(,4A
R2363	T3607	T3590	parataxis	4A,are
R2364	T3608	T3607	compound	Figure,4A
R2365	T3609	T3607	punct	", ",4A
R2366	T3610	T3611	amod	dotted,line
R2367	T3611	T3607	appos	line,4A
R2368	T3612	T3607	punct	),4A
R2369	T3613	T3614	punct	[,23
R2370	T3614	T3561	parataxis	23,known
R2371	T3615	T3614	punct	],23
R2372	T3616	T3561	punct	.,known
R2373	T3618	T3619	advmod	Thus,represents
R2374	T3620	T3619	punct	", ",represents
R2375	T3621	T3622	det	the,survival
R2376	T3622	T3619	nsubj	survival,represents
R2377	T3623	T3622	prep	of,survival
R2378	T3624	T3625	nmod	XpdTTD,†XPCS
R2379	T3625	T3627	nmod	†XPCS,cells
R2380	T3626	T3625	punct	/,†XPCS
R2381	T3627	T3623	pobj	cells,of
R2382	T3628	T3625	punct	(,†XPCS
R2383	T3629	T3625	cc	and,†XPCS
R2384	T3630	T3631	compound	XpdTTD,†XP
R2385	T3631	T3625	conj	†XP,†XPCS
R2386	T3632	T3631	punct	/,†XP
R2387	T3633	T3627	punct	),cells
R2388	T3634	T3619	advmod	likely,represents
R2389	T3635	T3636	det	a,level
R2390	T3636	T3619	dobj	level,represents
R2391	T3637	T3636	prep	of,level
R2392	T3638	T3639	compound	UV,resistance
R2393	T3639	T3637	pobj	resistance,of
R2394	T3640	T3641	dep	that,impart
R2395	T3641	T3636	relcl	impart,level
R2396	T3642	T3643	preconj	neither,allele
R2397	T3643	T3641	nsubj	allele,impart
R2398	T3644	T3643	amod	mutant,allele
R2399	T3645	T3641	aux	can,impart
R2400	T3646	T3641	prep	on,impart
R2401	T3647	T3648	poss	its,own
R2402	T3648	T3646	pobj	own,on
R2403	T3649	T3650	punct	(,Table
R2404	T3650	T3619	parataxis	Table,represents
R2405	T3651	T3650	nummod	2,Table
R2406	T3652	T3650	punct	),Table
R2407	T3653	T3619	punct	.,represents
R2408	T3655	T3656	amod	Significant,effects
R2409	T3656	T3657	nsubjpass	effects,observed
R2410	T3658	T3656	prep	of,effects
R2411	T3659	T3660	compound	compound,heterozygosity
R2412	T3660	T3658	pobj	heterozygosity,of
R2413	T3661	T3656	prep	on,effects
R2414	T3662	T3663	compound	NER,subpathways
R2415	T3663	T3661	pobj	subpathways,on
R2416	T3664	T3656	amod	relative,effects
R2417	T3665	T3664	prep	to,relative
R2418	T3666	T3667	compound	XpdTTD,KO
R2419	T3667	T3669	compound	KO,cells
R2420	T3668	T3667	punct	/,KO
R2421	T3669	T3665	pobj	cells,to
R2422	T3670	T3657	auxpass	were,observed
R2423	T3671	T3657	prep	in,observed
R2424	T3672	T3673	compound	XpdTTD,†XP
R2425	T3673	T3675	compound	†XP,cells
R2426	T3674	T3673	punct	/,†XP
R2427	T3675	T3671	pobj	cells,in
R2428	T3676	T3671	cc	but,in
R2429	T3677	T3678	advmod	only,for
R2430	T3678	T3671	conj	for,in
R2431	T3679	T3680	compound	UV,UDS
R2432	T3680	T3682	compound	UDS,activity
R2433	T3681	T3680	punct	-,UDS
R2434	T3682	T3678	pobj	activity,for
R2435	T3683	T3657	punct	.,observed
R2436	T3685	T3686	advmod	Finally,exhibited
R2437	T3687	T3686	punct	", ",exhibited
R2438	T3688	T3686	nsubj	none,exhibited
R2441	T3691	T3689	pobj	combinations,of
R2442	T3692	T3691	amod	mutant,combinations
R2443	T3693	T3691	compound	TFIIH,combinations
R2444	T3694	T3691	punct	(,combinations
R2445	T3695	T3691	acl	carrying,combinations
R2446	T3696	T3695	dobj	alterations,carrying
R2447	T3697	T3696	acl	associated,alterations
R2448	T3698	T3697	prep	with,associated
R2449	T3699	T3698	pobj	TTD,with
R2450	T3700	T3701	punct	[,XPDR722W
R2451	T3701	T3699	parataxis	XPDR722W,TTD
R2452	T3702	T3701	punct	],XPDR722W
R2453	T3703	T3699	punct	", ",TTD
R2454	T3704	T3699	conj	XPCS,TTD
R2455	T3705	T3706	punct	[,XPDG602D
R2456	T3706	T3704	parataxis	XPDG602D,XPCS
R2457	T3707	T3706	punct	],XPDG602D
R2458	T3708	T3704	punct	", ",XPCS
R2459	T3709	T3704	cc	or,XPCS
R2460	T3710	T3704	conj	XP,XPCS
R2461	T3711	T3712	punct	[,XPDR683W
R2462	T3712	T3710	parataxis	XPDR683W,XP
R2463	T3713	T3712	punct	],XPDR683W
R2464	T3714	T3686	punct	),exhibited
R2465	T3715	T3686	dobj	synergism,exhibited
R2466	T3716	T3686	prep	in,exhibited
R2467	T3717	T3718	det	an,reaction
R2468	T3718	T3716	pobj	reaction,in
R2469	T3719	T3720	advmod	in,vitro
R2470	T3720	T3718	amod	vitro,reaction
R2471	T3721	T3718	compound	NER,reaction
R2472	T3722	T3718	acl	reconstituted,reaction
R2473	T3723	T3722	prep	with,reconstituted
R2474	T3724	T3725	amod	different,complexes
R2475	T3725	T3723	pobj	complexes,with
R2476	T3726	T3725	amod	mutant,complexes
R2477	T3727	T3725	compound	TFIIH,complexes
R2478	T3728	T3729	punct	(,4D
R2479	T3729	T3686	parataxis	4D,exhibited
R2480	T3730	T3729	compound	Figure,4D
R2481	T3731	T3729	punct	),4D
R2482	T3732	T3686	punct	.,exhibited
R2483	T3734	T3735	advcl	Taken,are
R2484	T3736	T3734	advmod	together,Taken
R2485	T3737	T3735	punct	", ",are
R2486	T3738	T3739	det	these,data
R2487	T3739	T3735	nsubj	data,are
R2488	T3740	T3735	acomp	consistent,are
R2489	T3741	T3740	prep	with,consistent
R2490	T3742	T3743	amod	interallelic,complementation
R2491	T3743	T3741	pobj	complementation,with
R2492	T3744	T3743	prep	of,complementation
R2493	T3745	T3746	compound	UV,sensitivity
R2494	T3746	T3744	pobj	sensitivity,of
R2495	T3747	T3743	prep	in,complementation
R2496	T3748	T3747	pobj	cells,in
R2497	T3749	T3735	cc	but,are
R2498	T3750	T3735	conj	underscore,are
R2499	T3751	T3752	det	the,lack
R2500	T3752	T3750	dobj	lack,underscore
R2501	T3753	T3752	prep	of,lack
R2502	T3754	T3755	det	any,correlation
R2503	T3755	T3753	pobj	correlation,of
R2504	T3756	T3755	prep	between,correlation
R2505	T3757	T3758	npadvmod	UV,related
R2506	T3758	T3760	amod	related,characteristics
R2507	T3759	T3758	punct	-,related
R2508	T3760	T3756	pobj	characteristics,between
R2509	T3761	T3760	compound	repair,characteristics
R2510	T3762	T3760	cc	and,characteristics
R2511	T3763	T3764	compound	TTD,phenotypes
R2512	T3764	T3760	conj	phenotypes,characteristics
R2513	T3765	T3764	compound	progeroid,phenotypes
R2514	T3766	T3755	prep	in,correlation
R2515	T3767	T3768	compound	animal,models
R2516	T3768	T3766	pobj	models,in
R2517	T3769	T3735	punct	.,are
R2572	T3867	T3865	pobj	levels,of
R2573	T3868	T3867	prep	in,levels
R2574	T3869	T3870	amod	primary,fibroblasts
R2575	T3870	T3868	pobj	fibroblasts,in
R2576	T3871	T3870	prep	from,fibroblasts
R2577	T3872	T3871	pobj	patients,from
R2578	T3873	T3872	prep	with,patients
R2579	T3874	T3873	pobj	TTD,with
R2580	T3875	T3860	prep	compared,reduction
R2581	T3876	T3875	prep	with,compared
R2582	T3877	T3878	compound	wt,controls
R2583	T3878	T3876	pobj	controls,with
R2584	T3879	T3860	prep	due,reduction
R2585	T3880	T3879	pcomp	to,due
R2586	T3881	T3882	amod	reduced,stability
R2587	T3882	T3879	pobj	stability,due
R2588	T3883	T3884	punct	[,17
R2589	T3884	T3849	parataxis	17,shown
R2590	T3885	T3884	nummod	16,17
R2591	T3886	T3884	punct	",",17
R2592	T3887	T3884	punct	],17
R2593	T3888	T3849	punct	.,shown
R2594	T3890	T3891	prep	Despite,reduced
R2595	T3892	T3890	pobj	overexpression,Despite
R2596	T3893	T3892	prep	of,overexpression
R2597	T3894	T3893	pobj	mRNA,of
R2598	T3895	T3894	prep	from,mRNA
R2599	T3896	T3897	det	the,allele
R2600	T3897	T3895	pobj	allele,from
R2601	T3898	T3897	compound	XpdTTD,allele
R2602	T3899	T3892	amod	relative,overexpression
R2603	T3900	T3899	prep	to,relative
R2604	T3901	T3902	det	the,allele
R2605	T3902	T3900	pobj	allele,to
R2606	T3903	T3902	compound	wt,allele
R2607	T3904	T3905	punct	(,1E
R2608	T3905	T3892	parataxis	1E,overexpression
R2609	T3906	T3905	compound	Figure,1E
R2610	T3907	T3905	punct	),1E
R2611	T3908	T3891	punct	", ",reduced
R2612	T3909	T3910	compound	TFIIH,levels
R2613	T3910	T3891	nsubjpass	levels,reduced
R2614	T3911	T3910	compound	protein,levels
R2615	T3912	T3891	auxpass	were,reduced
R2616	T3913	T3891	prep	by,reduced
R2617	T3914	T3915	nummod	50,%
R2618	T3915	T3913	pobj	%,by
R2619	T3916	T3891	prep	in,reduced
R2620	T3917	T3918	amod	primary,fibroblasts
R2621	T3918	T3916	pobj	fibroblasts,in
R2622	T3919	T3918	compound	mouse,fibroblasts
R2623	T3920	T3921	compound	XpdTTD,TTD
R2624	T3921	T3918	compound	TTD,fibroblasts
R2625	T3922	T3921	punct	/,TTD
R2626	T3923	T3924	punct	(,4E
R2627	T3924	T3891	parataxis	4E,reduced
R2628	T3925	T3924	compound	Figure,4E
R2629	T3926	T3924	cc	and,4E
R2630	T3927	T3924	conj	4F,4E
R2631	T3928	T3924	punct	),4E
R2632	T3929	T3891	punct	", ",reduced
R2633	T3930	T3931	advmod	thereby,mimicking
R2634	T3931	T3891	advcl	mimicking,reduced
R2635	T3932	T3933	det	the,situation
R2636	T3933	T3931	dobj	situation,mimicking
R2637	T3934	T3931	prep	in,mimicking
R2638	T3935	T3936	amod	human,patients
R2639	T3936	T3934	pobj	patients,in
R2640	T3937	T3936	prep	with,patients
R2641	T3938	T3937	pobj	TTD,with
R2642	T3939	T3891	punct	.,reduced
R2643	T3941	T3942	prep	In,observed
R2644	T3943	T3941	pobj	accordance,In
R2645	T3944	T3943	prep	with,accordance
R2646	T3945	T3946	det	the,dosage
R2647	T3946	T3944	pobj	dosage,with
R2648	T3947	T3946	compound	gene,dosage
R2649	T3948	T3942	punct	", ",observed
R2650	T3949	T3950	det	a,reduction
R2651	T3950	T3942	nsubjpass	reduction,observed
R2652	T3951	T3950	amod	further,reduction
R2653	T3952	T3950	prep	of,reduction
R2654	T3953	T3954	quantmod	up,70
R2655	T3954	T3956	nummod	70,%
R2656	T3955	T3954	quantmod	to,70
R2657	T3956	T3952	pobj	%,of
R2658	T3957	T3956	prep	of,%
R2659	T3958	T3959	det	the,level
R2660	T3959	T3957	pobj	level,of
R2661	T3960	T3959	compound	wt,level
R2662	T3961	T3942	auxpass	was,observed
R2663	T3962	T3942	prep	in,observed
R2664	T3963	T3964	amod	hemizygous,cells
R2665	T3964	T3962	pobj	cells,in
R2666	T3965	T3966	compound	XpdTTD,KO
R2667	T3966	T3964	compound	KO,cells
R2668	T3967	T3966	punct	/,KO
R2669	T3968	T3942	punct	.,observed
R2670	T3970	T3971	advcl	Consistent,was
R2671	T3972	T3970	prep	with,Consistent
R2672	T3973	T3974	amod	low,levels
R2673	T3974	T3972	pobj	levels,with
R2674	T3975	T3976	compound	mRNA,expression
R2675	T3976	T3974	compound	expression,levels
R2676	T3977	T3971	punct	", ",was
R2677	T3978	T3979	preconj	neither,allele
R2678	T3979	T3971	nsubj	allele,was
R2679	T3980	T3981	det	the,Xpd†XPCS
R2680	T3981	T3979	nmod	Xpd†XPCS,allele
R2681	T3982	T3981	cc	nor,Xpd†XPCS
R2682	T3983	T3984	det	the,Xpd†XP
R2683	T3984	T3981	conj	Xpd†XP,Xpd†XPCS
R2684	T3985	T3971	acomp	able,was
R2685	T3986	T3987	aux	to,restore
R2686	T3987	T3985	xcomp	restore,able
R2687	T3988	T3989	compound	TFIIH,abundance
R2688	T3989	T3987	dobj	abundance,restore
R2689	T3990	T3987	prep	to,restore
R2690	T3991	T3992	compound	wt,levels
R2691	T3992	T3990	pobj	levels,to
R2692	T3993	T3987	prep	in,restore
R2693	T3994	T3995	compound	XpdTTD,cells
R2694	T3995	T3993	pobj	cells,in
R2695	T3996	T3995	compound	compound,cells
R2696	T3997	T3995	compound	heterozygote,cells
R2697	T3998	T3999	punct	(,4E
R2698	T3999	T3971	parataxis	4E,was
R2699	T4000	T3999	compound	Figure,4E
R2700	T4001	T3999	cc	and,4E
R2701	T4002	T3999	conj	4F,4E
R2702	T4003	T3999	punct	),4E
R2703	T4004	T3971	punct	.,was
R2704	T4006	T4007	advmod	Thus,were
R2705	T4008	T4007	punct	", ",were
R2706	T4009	T4010	det	the,survival
R2707	T4010	T4007	nsubj	survival,were
R2708	T4011	T4010	amod	improved,survival
R2709	T4012	T4010	compound	UV,survival
R2710	T4013	T4010	acl	observed,survival
R2711	T4014	T4013	prep	in,observed
R2712	T4015	T4016	compound	compound,cells
R2713	T4016	T4014	pobj	cells,in
R2714	T4017	T4016	compound	heterozygote,cells
R2715	T4018	T4019	punct	(,4A
R2716	T4019	T4013	parataxis	4A,observed
R2717	T4020	T4019	compound	Figure,4A
R2718	T4021	T4019	punct	),4A
R2719	T4022	T4013	cc	and,observed
R2720	T4023	T4024	advmod	likely,rescue
R2721	T4024	T4013	conj	rescue,observed
R2722	T4025	T4024	det	the,rescue
R2723	T4026	T4024	prep	of,rescue
R2724	T4027	T4028	compound	TTD,symptoms
R2725	T4028	T4026	pobj	symptoms,of
R2726	T4029	T4028	compound	progeroid,symptoms
R2727	T4030	T4031	punct	(,Figure
R2728	T4031	T4024	parataxis	Figure,rescue
R2729	T4032	T4031	nummod	3,Figure
R2730	T4033	T4031	punct	),Figure
R2731	T4034	T4007	neg	not,were
R2732	T4035	T4007	prep	due,were
R2733	T4036	T4035	pcomp	to,due
R2734	T4037	T4035	pobj	normalisation,due
R2735	T4038	T4037	prep	of,normalisation
R2736	T4039	T4040	compound	TFIIH,levels
R2737	T4040	T4038	pobj	levels,of
R2738	T4041	T4007	punct	", ",were
R2739	T4042	T4007	advcl	suggesting,were
R2740	T4043	T4044	advmod	a,qualitative
R2741	T4044	T4045	amod	qualitative,effect
R2742	T4045	T4042	dobj	effect,suggesting
R2743	T4046	T4047	advmod	rather,than
R2744	T4047	T4044	cc	than,qualitative
R2745	T4048	T4049	advmod	a,quantitative
R2746	T4049	T4044	conj	quantitative,qualitative
R2747	T4050	T4045	prep	on,effect
R2748	T4051	T4052	det	these,phenotypes
R2749	T4052	T4050	pobj	phenotypes,on
R2750	T4053	T4054	advmod	in,vivo
R2751	T4054	T4045	advmod	vivo,effect
R2752	T4055	T4007	punct	.,were
R2753	T4057	T4058	prep	In,affect
R2754	T4059	T4057	pobj	contrast,In
R2755	T4060	T4058	punct	", ",affect
R2756	T4061	T4062	det	the,level
R2757	T4062	T4058	nsubj	level,affect
R2758	T4063	T4062	prep	of,level
R2759	T4064	T4065	compound	XPCS,expression
R2760	T4065	T4063	pobj	expression,of
R2761	T4066	T4065	compound	mRNA,expression
R2762	T4067	T4058	aux	did,affect
R2763	T4068	T4069	det	the,ability
R2764	T4069	T4058	dobj	ability,affect
R2765	T4070	T4069	prep	of,ability
R2766	T4071	T4072	det	the,protein
R2767	T4072	T4070	pobj	protein,of
R2768	T4073	T4072	amod	encoded,protein
R2769	T4074	T4072	punct	(,protein
R2770	T4075	T4072	appos	XPDG602D,protein
R2771	T4076	T4069	punct	),ability
R2772	T4077	T4078	aux	to,restore
R2773	T4078	T4069	acl	restore,ability
R2774	T4079	T4080	det	the,phenotype
R2775	T4080	T4078	dobj	phenotype,restore
R2776	T4081	T4080	compound	TTD,phenotype
R2777	T4082	T4080	compound	hair,phenotype
R2778	T4083	T4078	prep	to,restore
R2779	T4084	T4083	amod	normal,to
R2780	T4085	T4058	punct	.,affect
R2781	T4087	T4088	advmod	Notably,had
R2782	T4089	T4088	punct	", ",had
R2783	T4090	T4091	compound	XpdTTD, †XPCS
R2784	T4091	T4093	compound	†XPCS,animals
R2785	T4092	T4091	punct	/, †XPCS
R2786	T4093	T4088	nsubj	animals,had
R2787	T4094	T4095	det	a,phenotype
R2788	T4095	T4088	dobj	phenotype,had
R2789	T4096	T4095	amod	partial,phenotype
R2790	T4097	T4095	compound	TTD,phenotype
R2791	T4098	T4095	compound	hair,phenotype
R2792	T4099	T4095	punct	", ",phenotype
R2793	T4100	T4095	acl	correlating,phenotype
R2794	T4101	T4100	prep	with,correlating
R2795	T4102	T4103	amod	low,levels
R2796	T4103	T4101	pobj	levels,with
R2797	T4104	T4103	prep	of,levels
R2798	T4105	T4106	compound	Xpd†XPCS,expression
R2799	T4106	T4104	pobj	expression,of
R2800	T4107	T4088	punct	", ",had
R2801	T4108	T4109	mark	whereas,had
R2802	T4109	T4088	advcl	had,had
R2803	T4110	T4111	compound	XpdTTD,XPCS
R2804	T4111	T4113	compound	XPCS,animals
R2805	T4112	T4111	punct	/,XPCS
R2806	T4113	T4109	nsubj	animals,had
R2807	T4114	T4115	compound	wt,hair
R2808	T4115	T4109	dobj	hair,had
R2809	T4116	T4115	punct	", ",hair
R2810	T4117	T4115	acl	correlating,hair
R2811	T4118	T4117	prep	with,correlating
R2827	T4134	T4088	punct	.,had
R2828	T4136	T4137	advmod	Thus,affected
R2829	T4138	T4137	punct	", ",affected
R2830	T4139	T4140	det	the,range
R2831	T4140	T4137	nsubj	range,affected
R2832	T4141	T4140	prep	of,range
R2833	T4142	T4143	compound	expression,levels
R2834	T4143	T4141	pobj	levels,of
R2835	T4144	T4140	prep	from,range
R2836	T4145	T4146	det	these,alleles
R2837	T4146	T4144	pobj	alleles,from
R2838	T4147	T4146	nummod	two,alleles
R2839	T4148	T4146	amod	mutant,alleles
R2840	T4149	T4150	poss	their,ability
R2841	T4150	T4137	dobj	ability,affected
R2842	T4151	T4152	aux	to,complement
R2843	T4152	T4150	acl	complement,ability
R2844	T4153	T4154	det	some,phenotypes
R2845	T4154	T4152	dobj	phenotypes,complement
R2846	T4155	T4156	punct	(,hair
R2847	T4156	T4154	parataxis	hair,phenotypes
R2848	T4157	T4156	punct	),hair
R2849	T4158	T4137	punct	.,affected
R2850	T4160	T4161	det	An,overview
R2851	T4161	T4162	nsubjpass	overview,presented
R2852	T4163	T4161	prep	of,overview
R2853	T4164	T4165	det	the,relationships
R2854	T4165	T4163	pobj	relationships,of
R2855	T4166	T4165	amod	functional,relationships
R2856	T4167	T4165	prep	between,relationships
R2857	T4168	T4169	compound	Xpd,alleles
R2858	T4169	T4167	pobj	alleles,between
R2859	T4170	T4169	punct	", ",alleles
R2860	T4171	T4169	conj	phenotypes,alleles
R2861	T4172	T4171	punct	", ",phenotypes
R2862	T4173	T4171	cc	and,phenotypes
R2863	T4174	T4175	det	the,function
R2864	T4175	T4171	conj	function,phenotypes
R2865	T4176	T4175	amod	presumed,function
R2866	T4177	T4175	amod	underlying,function
R2867	T4178	T4175	compound	TFIIH,function
R2868	T4179	T4165	prep	in,relationships
R2869	T4180	T4179	pobj	mice,in
R2870	T4181	T4180	cc	and,mice
R2871	T4182	T4180	conj	cells,mice
R2872	T4183	T4162	auxpass	is,presented
R2873	T4184	T4162	prep	in,presented
R2874	T4185	T4184	pobj	Table,in
R2875	T4186	T4185	nummod	2,Table
R2876	T4187	T4162	punct	.,presented
R5707	T8564	T8565	compound	TFIIH,Functions
R5708	T8566	T8565	cc	and,Functions
R5709	T8567	T8565	conj	Mechanisms,Functions
R5710	T8568	T8567	prep	of,Mechanisms
R5711	T8569	T8570	npadvmod	XPD,Associated
R5712	T8570	T8572	amod	Associated,Pleiotropy
R5713	T8571	T8570	punct	-,Associated
R5714	T8572	T8568	pobj	Pleiotropy,of
R5715	T8573	T8572	compound	Disease,Pleiotropy
R5716	T8575	T8576	punct	(,A
R5717	T8576	T8577	meta	A,survival
R5718	T8578	T8576	punct	),A
R5719	T8579	T8577	amod	Cellular,survival
R5720	T8580	T8577	prep	after,survival
R5721	T8581	T8582	compound	UV,irradiation
R5722	T8582	T8580	pobj	irradiation,after
R5723	T8583	T8577	punct	.,survival
R5724	T8585	T8586	nsubjpass	Rescue,illustrated
R5725	T8587	T8585	prep	of,Rescue
R5726	T8588	T8589	amod	hemizygous,survival
R5727	T8589	T8587	pobj	survival,of
R5728	T8590	T8591	compound	XpdTTD,KO
R5729	T8591	T8589	compound	KO,survival
R5730	T8592	T8591	punct	/,KO
R5731	T8593	T8585	prep	by,Rescue
R5732	T8594	T8595	nmod	Xpd†XPCS,alleles
R5733	T8595	T8593	pobj	alleles,by
R5734	T8596	T8594	cc	and,Xpd†XPCS
R5735	T8597	T8594	conj	Xpd†XP,Xpd†XPCS
R5736	T8598	T8586	auxpass	is,illustrated
R5737	T8599	T8586	agent	by,illustrated
R5738	T8600	T8599	pobj	arrows,by
R5739	T8601	T8600	acl	marked,arrows
R5740	T8602	T8601	oprd	A,marked
R5741	T8603	T8602	cc	and,A
R5742	T8604	T8602	conj	B,A
R5743	T8605	T8601	punct	", ",marked
R5744	T8606	T8601	advmod	respectively,marked
R5745	T8607	T8586	punct	.,illustrated
R5746	T8609	T8610	compound	UV,survival
R5747	T8610	T8611	nsubjpass	survival,depicted
R5748	T8612	T8610	prep	of,survival
R5749	T8613	T8614	amod	homozygous,cells
R5750	T8614	T8612	pobj	cells,of
R5751	T8615	T8616	compound	XpdXPCS,XPCS
R5752	T8616	T8614	compound	XPCS,cells
R5753	T8617	T8616	punct	/,XPCS
R5754	T8618	T8619	punct	(,asterisk
R5755	T8619	T8614	parataxis	asterisk,cells
R5756	T8620	T8619	punct	),asterisk
R5757	T8621	T8614	prep	from,cells
R5758	T8622	T8623	det	the,allele
R5759	T8623	T8621	pobj	allele,from
R5760	T8624	T8625	advmod	normally,expressed
R5761	T8625	T8623	amod	expressed,allele
R5762	T8626	T8623	amod	viable,allele
R5763	T8627	T8628	punct	(,XpdXPCS
R5764	T8628	T8623	parataxis	XpdXPCS,allele
R5765	T8629	T8628	punct	),XpdXPCS
R5766	T8630	T8611	auxpass	is,depicted
R5767	T8631	T8611	prep	by,depicted
R5768	T8632	T8633	det	a,line
R5769	T8633	T8631	pobj	line,by
R5770	T8634	T8633	amod	dotted,line
R5771	T8635	T8611	punct	.,depicted
R5772	T8637	T8638	compound	Survival,curves
R5773	T8638	T8639	nsubj	curves,represent
R5774	T8639	T8640	ccomp	represent,included
R5775	T8641	T8642	det	an,average
R5776	T8642	T8639	dobj	average,represent
R5777	T8643	T8642	prep	of,average
R5778	T8644	T8645	nummod	four,experiments
R5779	T8645	T8643	pobj	experiments,of
R5780	T8646	T8645	amod	independent,experiments
R5781	T8647	T8640	punct	;,included
R5782	T8648	T8649	quantmod	1,2
R5783	T8649	T8651	nummod	2,lines
R5784	T8650	T8649	punct	–,2
R5785	T8651	T8640	nsubjpass	lines,included
R5786	T8652	T8651	compound	cell,lines
R5787	T8653	T8651	prep	per,lines
R5788	T8654	T8653	pobj	genotype,per
R5789	T8655	T8640	auxpass	were,included
R5790	T8656	T8640	prep	in,included
R5791	T8657	T8658	det	each,experiment
R5792	T8658	T8656	pobj	experiment,in
R5793	T8659	T8640	punct	.,included
R5794	T8661	T8662	compound	Error,bars
R5795	T8662	T8663	nsubj	bars,indicate
R5796	T8664	T8663	dobj	SEM,indicate
R5797	T8665	T8664	prep	between,SEM
R5798	T8666	T8665	pobj	experiments,between
R5799	T8667	T8663	punct	.,indicate
R5800	T8669	T8670	punct	(,B
R5801	T8670	T8671	meta	B,UDS
R5802	T8672	T8670	punct	),B
R5803	T8673	T8671	compound	UV,UDS
R5804	T8674	T8671	punct	-,UDS
R5805	T8675	T8671	punct	", ",UDS
R5806	T8676	T8677	det	a,measure
R5807	T8677	T8671	appos	measure,UDS
R5808	T8678	T8677	prep	of,measure
R5809	T8679	T8680	amod	global,repair
R5810	T8680	T8678	pobj	repair,of
R5811	T8681	T8680	compound	genome,repair
R5812	T8682	T8671	punct	.,UDS
R5813	T8684	T8685	dep	Number,included
R5814	T8686	T8684	prep	of,Number
R5815	T8687	T8686	pobj	experiments,of
R5816	T8688	T8685	punct	: ,included
R5817	T8689	T8690	nsubj	n,15
R5818	T8690	T8685	ccomp	15,included
R5819	T8691	T8690	punct	=,15
R5820	T8692	T8693	punct	(,XpdTTD
R5821	T8693	T8690	parataxis	XpdTTD,15
R5822	T8694	T8693	punct	/,XpdTTD
R5823	T8695	T8693	dep	TTD,XpdTTD
R5824	T8696	T8693	punct	),XpdTTD
R5825	T8697	T8685	punct	", ",included
R5826	T8698	T8699	nsubj	n,6
R5827	T8699	T8685	ccomp	6,included
R5828	T8700	T8699	punct	=,6
R5829	T8701	T8702	punct	(,KO
R5830	T8702	T8699	parataxis	KO,6
R5831	T8703	T8702	compound	XpdTTD,KO
R5832	T8704	T8702	punct	/,KO
R5833	T8705	T8702	punct	),KO
R5834	T8706	T8685	punct	", ",included
R5835	T8707	T8708	nsubj	n,4
R5836	T8708	T8685	ccomp	4,included
R5837	T8709	T8708	punct	=,4
R5838	T8710	T8711	punct	(,†XPCS
R5839	T8711	T8708	parataxis	†XPCS,4
R5840	T8712	T8711	compound	XpdTTD,†XPCS
R5841	T8713	T8711	punct	/,†XPCS
R5842	T8714	T8711	punct	),†XPCS
R5843	T8715	T8685	punct	", ",included
R5844	T8716	T8717	nsubj	n,2
R5845	T8717	T8685	ccomp	2,included
R5846	T8718	T8717	punct	=,2
R5847	T8719	T8720	punct	(,†XP
R5848	T8720	T8717	parataxis	†XP,2
R5849	T8721	T8720	compound	XpdTTD,†XP
R5850	T8722	T8720	punct	/,†XP
R5851	T8723	T8720	punct	),†XP
R5852	T8724	T8685	punct	;,included
R5853	T8725	T8726	quantmod	1,2
R5854	T8726	T8728	nummod	2,lines
R5855	T8727	T8726	punct	–,2
R5856	T8728	T8685	nsubjpass	lines,included
R5857	T8729	T8728	compound	cell,lines
R5858	T8730	T8728	prep	per,lines
R5859	T8731	T8730	pobj	genotype,per
R5860	T8732	T8685	auxpass	were,included
R5861	T8733	T8685	prep	in,included
R5862	T8734	T8735	det	each,experiment
R5863	T8735	T8733	pobj	experiment,in
R5864	T8736	T8685	punct	.,included
R5865	T8738	T8739	det	The,asterisk
R5866	T8739	T8740	nsubj	asterisk,indicates
R5867	T8740	T8741	ccomp	indicates,indicate
R5868	T8742	T8743	amod	significant,difference
R5869	T8743	T8740	dobj	difference,indicates
R5870	T8744	T8743	prep	with,difference
R5871	T8745	T8746	compound	XpdTTD,TTD
R5872	T8746	T8744	pobj	TTD,with
R5873	T8747	T8746	punct	/,TTD
R5874	T8748	T8741	punct	;,indicate
R5875	T8749	T8741	nsubj	crosses,indicate
R5876	T8750	T8751	amod	significant,differences
R5877	T8751	T8741	dobj	differences,indicate
R5878	T8752	T8751	prep	with,differences
R5879	T8753	T8754	compound	XpdTTD,KO
R5880	T8754	T8752	pobj	KO,with
R5881	T8755	T8754	punct	/,KO
R5882	T8756	T8741	punct	.,indicate
R5883	T8758	T8759	punct	(,C
R5884	T8759	T8760	meta	C,RRS
R5885	T8761	T8759	punct	),C
R5886	T8762	T8760	compound	UV,RRS
R5887	T8763	T8760	punct	-,RRS
R5888	T8764	T8760	punct	", ",RRS
R5889	T8765	T8766	det	a,measure
R5890	T8766	T8760	appos	measure,RRS
R5891	T8767	T8766	prep	of,measure
R5892	T8768	T8769	npadvmod	transcription,coupled
R5893	T8769	T8771	amod	coupled,repair
R5894	T8770	T8769	punct	-,coupled
R5895	T8771	T8767	pobj	repair,of
R5896	T8772	T8771	prep	of,repair
R5897	T8773	T8774	npadvmod	UV,induced
R5898	T8774	T8776	amod	induced,lesions
R5899	T8775	T8774	punct	-,induced
R5900	T8776	T8772	pobj	lesions,of
R5901	T8777	T8760	punct	.,RRS
R5902	T8779	T8780	dep	Number,included
R5903	T8781	T8779	prep	of,Number
R5904	T8782	T8781	pobj	experiments,of
R5905	T8783	T8780	punct	: ,included
R5906	T8784	T8785	nsubj	n,7
R5907	T8785	T8780	ccomp	7,included
R5908	T8786	T8785	punct	=,7
R5909	T8787	T8788	punct	(,TTD
R5910	T8788	T8785	parataxis	TTD,7
R5911	T8789	T8788	compound	XpdTTD,TTD
R5912	T8790	T8788	punct	/,TTD
R5913	T8791	T8788	punct	),TTD
R5914	T8792	T8780	punct	", ",included
R5915	T8793	T8794	nsubj	n,2
R5916	T8794	T8780	ccomp	2,included
R5917	T8795	T8794	punct	=,2
R5918	T8796	T8797	punct	(,KO
R5919	T8797	T8794	parataxis	KO,2
R5920	T8798	T8797	compound	XpdTTD,KO
R5921	T8799	T8797	punct	/,KO
R5922	T8800	T8797	punct	),KO
R5923	T8801	T8780	punct	", ",included
R5924	T8802	T8803	nsubj	n,4
R5925	T8803	T8780	ccomp	4,included
R5926	T8804	T8803	punct	=,4
R5927	T8805	T8806	punct	(,†XPCS
R5928	T8806	T8803	parataxis	†XPCS,4
R5929	T8807	T8806	compound	XpdTTD,†XPCS
R5930	T8808	T8806	punct	/,†XPCS
R5931	T8809	T8806	punct	),†XPCS
R5932	T8810	T8780	punct	", ",included
R5933	T8811	T8812	nsubj	n,2
R5934	T8812	T8780	ccomp	2,included
R5935	T8813	T8812	punct	=,2
R5936	T8814	T8815	punct	(,†XP
R5937	T8815	T8812	parataxis	†XP,2
R5938	T8816	T8815	compound	XpdTTD,†XP
R5939	T8817	T8815	punct	/,†XP
R5940	T8818	T8815	punct	),†XP
R5941	T8819	T8780	punct	;,included
R5942	T8820	T8821	quantmod	1,2
R5943	T8821	T8823	nummod	2,lines
R5944	T8822	T8821	punct	–,2
R5945	T8823	T8780	nsubjpass	lines,included
R5946	T8824	T8823	compound	cell,lines
R5947	T8825	T8823	prep	per,lines
R5948	T8826	T8825	pobj	genotype,per
R5949	T8827	T8780	auxpass	were,included
R5950	T8828	T8780	prep	in,included
R5951	T8829	T8830	det	each,experiment
R5952	T8830	T8828	pobj	experiment,in
R5953	T8831	T8780	punct	.,included
R5954	T8833	T8834	punct	(,D
R5955	T8834	T8835	meta	D,activity
R5956	T8836	T8834	punct	),D
R5957	T8837	T8838	compound	Incision,excision
R5958	T8838	T8835	compound	excision,activity
R5959	T8839	T8838	punct	/,excision
R5960	T8840	T8835	prep	of,activity
R5961	T8841	T8840	pobj	combinations,of
R5962	T8842	T8841	prep	of,combinations
R5963	T8843	T8844	amod	altered,complexes
R5964	T8844	T8842	pobj	complexes,of
R5965	T8845	T8844	compound	TFIIH,complexes
R5966	T8846	T8844	prep	in,complexes
R5967	T8847	T8848	det	a,reaction
R5968	T8848	T8846	pobj	reaction,in
R5969	T8849	T8848	amod	reconstituted,reaction
R5970	T8850	T8848	compound	NER,reaction
R5971	T8851	T8835	punct	.,activity
R5972	T8853	T8854	amod	Equal,amounts
R5973	T8854	T8855	nsubjpass	amounts,mixed
R5974	T8856	T8854	prep	of,amounts
R5975	T8857	T8858	amod	single,populations
R5976	T8858	T8856	pobj	populations,of
R5977	T8859	T8857	cc	or,single
R5978	T8860	T8857	conj	mixed,single
R5979	T8861	T8858	prep	of,populations
R5980	T8862	T8863	amod	recombinant,TFIIHs
R5981	T8863	T8861	pobj	TFIIHs,of
R5982	T8864	T8858	punct	(,populations
R5983	T8865	T8858	acl	containing,populations
R5984	T8866	T8865	dobj	XPD,containing
R5985	T8867	T8866	punct	", ",XPD
R5986	T8868	T8866	conj	XPB,XPD
R5987	T8869	T8868	punct	", ",XPB
R5988	T8870	T8868	conj	p62,XPB
R5989	T8871	T8870	punct	", ",p62
R5990	T8872	T8870	conj	p52,p62
R5991	T8873	T8872	punct	", ",p52
R5992	T8874	T8875	compound	His,p44
R5993	T8875	T8872	conj	p44,p52
R5994	T8876	T8875	punct	-,p44
R5995	T8877	T8875	punct	", ",p44
R5996	T8878	T8879	compound	Flag,p34
R5997	T8879	T8875	conj	p34,p44
R5998	T8880	T8879	punct	-,p34
R5999	T8881	T8879	punct	", ",p34
R6000	T8882	T8879	conj	cdk7,p34
R6001	T8883	T8882	punct	", ",cdk7
R6002	T8884	T8885	compound	cyclin,H
R6003	T8885	T8882	conj	H,cdk7
R6004	T8886	T8885	punct	", ",H
R6005	T8887	T8885	conj	Mat1,H
R6006	T8888	T8887	punct	", ",Mat1
R6007	T8889	T8887	cc	and,Mat1
R6008	T8890	T8887	conj	p8,Mat1
R6009	T8891	T8855	punct	),mixed
R6010	T8892	T8855	auxpass	were,mixed
R6011	T8893	T8855	prep	with,mixed
R6012	T8894	T8895	amod	recombinant,XPG
R6013	T8895	T8893	pobj	XPG,with
R6014	T8896	T8895	punct	", ",XPG
R6015	T8897	T8898	compound	XPF,ERCC1
R6016	T8898	T8895	appos	ERCC1,XPG
R6017	T8899	T8898	punct	/,ERCC1
R6018	T8900	T8895	punct	", ",XPG
R6019	T8901	T8902	compound	XPC,hHR23B
R6020	T8902	T8895	appos	hHR23B,XPG
R6021	T8903	T8902	punct	/,hHR23B
R6022	T8904	T8895	punct	", ",XPG
R6023	T8905	T8895	appos	RPA,XPG
R6024	T8906	T8895	punct	", ",XPG
R6025	T8907	T8895	cc	and,XPG
R6026	T8908	T8909	det	a,substrate
R6027	T8909	T8895	conj	substrate,XPG
R6028	T8910	T8909	amod	radiolabelled,substrate
R6029	T8911	T8909	amod	synthetic,substrate
R6030	T8912	T8909	compound	NER,substrate
R6031	T8913	T8855	punct	.,mixed
R6032	T8915	T8916	det	The,products
R6033	T8916	T8918	nsubjpass	products,visualised
R6034	T8917	T8916	compound	excision,products
R6035	T8919	T8920	punct	(,nucleotides
R6036	T8920	T8916	parataxis	nucleotides,products
R6037	T8921	T8922	quantmod	26,34
R6038	T8922	T8920	nummod	34,nucleotides
R6039	T8923	T8922	punct	–,34
R6040	T8924	T8920	prep	in,nucleotides
R6041	T8925	T8924	pobj	length,in
R6042	T8926	T8920	punct	),nucleotides
R6043	T8927	T8918	auxpass	were,visualised
R6044	T8928	T8918	prep	at,visualised
R6045	T8929	T8930	compound	nucleotide,resolution
R6046	T8930	T8928	pobj	resolution,at
R6047	T8931	T8918	prep	on,visualised
R6048	T8932	T8933	det	a,gel
R6049	T8933	T8931	pobj	gel,on
R6050	T8934	T8933	amod	denaturing,gel
R6051	T8935	T8933	compound	polyacrylamide,gel
R6052	T8936	T8937	mark	as,indicated
R6053	T8937	T8918	advcl	indicated,visualised
R6054	T8938	T8918	punct	.,visualised
R6055	T8941	T8942	det	the,activity
R6056	T8942	T8940	dobj	activity,Note
R6057	T8943	T8942	amod	weak,activity
R6058	T8944	T8942	acl	corresponding,activity
R6059	T8945	T8944	prep	to,corresponding
R6060	T8946	T8947	det	each,complex
R6061	T8947	T8945	pobj	complex,to
R6062	T8948	T8947	amod	single,complex
R6063	T8949	T8948	cc	and,single
R6064	T8950	T8948	conj	combined,single
R6065	T8951	T8947	compound	TFIIH,complex
R6066	T8952	T8953	punct	(,3
R6067	T8953	T8947	parataxis	3,complex
R6068	T8954	T8953	nmod	lanes,3
R6069	T8955	T8956	punct	–,8
R6070	T8956	T8953	prep	8,3
R6071	T8957	T8953	punct	),3
R6072	T8958	T8944	advcl	relative,corresponding
R6073	T8959	T8958	prep	to,relative
R6074	T8960	T8961	det	the,wt
R6075	T8961	T8959	pobj	wt,to
R6076	T8962	T8963	punct	(,lane
R6077	T8963	T8961	parataxis	lane,wt
R6078	T8964	T8963	nummod	1,lane
R6079	T8965	T8963	punct	),lane
R6080	T8966	T8961	cc	and,wt
R6081	T8967	T8968	amod	negative,controls
R6082	T8968	T8961	conj	controls,wt
R6083	T8969	T8970	punct	(,lane
R6084	T8970	T8968	parataxis	lane,controls
R6085	T8971	T8970	nummod	2,lane
R6086	T8972	T8970	punct	),lane
R6087	T8973	T8940	punct	.,Note
R6088	T8975	T8976	punct	(,E
R6089	T8976	T8977	meta	E,reduction
R6090	T8978	T8976	punct	),E
R6091	T8979	T8977	nmod	Xpd,reduction
R6092	T8980	T8981	npadvmod	dose,dependent
R6093	T8981	T8977	amod	dependent,reduction
R6094	T8982	T8981	punct	-,dependent
R6095	T8983	T8977	prep	of,reduction
R6096	T8984	T8983	pobj	TFIIH,of
R6097	T8985	T8977	prep	in,reduction
R6098	T8986	T8987	amod	homozygous,TTD
R6099	T8987	T8990	nmod	TTD,cells
R6100	T8988	T8987	nmod	XpdTTD,TTD
R6101	T8989	T8987	punct	/,TTD
R6102	T8990	T8985	pobj	cells,in
R6103	T8991	T8987	punct	", ",TTD
R6104	T8992	T8993	amod	hemizygous,KO
R6105	T8993	T8987	conj	KO,TTD
R6106	T8994	T8993	compound	XpdTTD,KO
R6107	T8995	T8993	punct	/,KO
R6108	T8996	T8993	punct	", ",KO
R6109	T8997	T8993	cc	and,KO
R6110	T8998	T8999	nmod	compound,†XPCS
R6111	T8999	T8993	conj	†XPCS,KO
R6112	T9000	T8999	amod	heterozygous,†XPCS
R6113	T9001	T8999	compound	XpdTTD,†XPCS
R6114	T9002	T8999	punct	/,†XPCS
R6115	T9003	T8999	cc	and,†XPCS
R6116	T9004	T9005	compound	XpdTTD,†XP
R6117	T9005	T8999	conj	†XP,†XPCS
R6118	T9006	T9005	punct	/,†XP
R6119	T9007	T8977	prep	by,reduction
R6120	T9008	T9009	amod	comparative,immunofluorescence
R6121	T9009	T9007	pobj	immunofluorescence,by
R6122	T9010	T9009	prep	of,immunofluorescence
R6123	T9011	T9012	det	the,subunit
R6124	T9012	T9010	pobj	subunit,of
R6125	T9013	T9012	compound	p62,subunit
R6126	T9014	T9012	prep	of,subunit
R6127	T9015	T9014	pobj	TFIIH,of
R6128	T9016	T8977	punct	.,reduction
R6129	T9018	T9019	amod	Roman,numerals
R6130	T9019	T9020	nsubj	numerals,represent
R6131	T9021	T9022	amod	different,slides
R6132	T9022	T9020	dobj	slides,represent
R6133	T9023	T9022	amod	microscopic,slides
R6134	T9024	T9020	cc	and,represent
R6135	T9025	T9026	amod	Arabic,numerals
R6136	T9026	T9027	nsubj	numerals,lines
R6137	T9027	T9020	conj	lines,represent
R6138	T9028	T9027	amod	different,lines
R6139	T9029	T9027	compound	cell,lines
R6140	T9030	T9027	acl	labelled,lines
R6141	T9031	T9032	mark	as,follows
R6142	T9032	T9030	advcl	follows,labelled
R6143	T9033	T9027	punct	: ,lines
R6144	T9034	T9035	punct	(,I
R6145	T9035	T9036	meta	I,cells
R6146	T9036	T9027	dep	cells,lines
R6147	T9037	T9035	punct	),I
R6148	T9038	T9036	compound	wt,cells
R6149	T9039	T9040	punct	(,1
R6150	T9040	T9036	parataxis	1,cells
R6151	T9041	T9040	punct	),1
R6152	T9042	T9036	acl	labelled,cells
R6153	T9043	T9042	prep	with,labelled
R6154	T9044	T9045	nummod	2,μm
R6155	T9045	T9047	compound	μm,beads
R6156	T9046	T9045	punct	-,μm
R6157	T9047	T9043	pobj	beads,with
R6158	T9048	T9036	punct	", ",cells
R6159	T9049	T9050	compound	XpdTTD,TTD
R6160	T9050	T9052	compound	TTD,cells
R6161	T9051	T9050	punct	/,TTD
R6162	T9052	T9036	conj	cells,cells
R6163	T9053	T9054	punct	(,2
R6164	T9054	T9052	parataxis	2,cells
R6165	T9055	T9054	punct	),2
R6166	T9056	T9052	prep	with,cells
R6167	T9057	T9058	nummod	0.79,μm
R6168	T9058	T9060	compound	μm,beads
R6169	T9059	T9058	punct	-,μm
R6170	T9060	T9056	pobj	beads,with
R6171	T9061	T9052	punct	", ",cells
R6172	T9062	T9052	cc	and,cells
R6173	T9063	T9064	compound	XpdTTD,KO
R6174	T9064	T9066	compound	KO,cells
R6175	T9065	T9064	punct	/,KO
R6176	T9066	T9052	conj	cells,cells
R6177	T9067	T9068	punct	(,3
R6178	T9068	T9066	parataxis	3,cells
R6179	T9069	T9068	punct	),3
R6180	T9070	T9066	prep	with,cells
R6181	T9071	T9072	det	no,beads
R6182	T9072	T9070	pobj	beads,with
R6183	T9073	T9036	punct	;,cells
R6184	T9074	T9075	punct	(,II
R6185	T9075	T9076	meta	II,cells
R6186	T9076	T9036	conj	cells,cells
R6187	T9077	T9075	punct	),II
R6188	T9078	T9076	compound	wt,cells
R6189	T9079	T9080	punct	(,1
R6190	T9080	T9076	parataxis	1,cells
R6191	T9081	T9080	punct	),1
R6192	T9082	T9076	acl	labelled,cells
R6193	T9083	T9082	prep	with,labelled
R6194	T9084	T9085	nummod	0.79,μm
R6195	T9085	T9087	compound	μm,beads
R6196	T9086	T9085	punct	-,μm
R6197	T9087	T9083	pobj	beads,with
R6198	T9088	T9076	cc	and,cells
R6199	T9089	T9090	compound	XpdTTD,†XPCS
R6200	T9090	T9092	compound	†XPCS,cells
R6201	T9091	T9090	punct	/,†XPCS
R6202	T9092	T9076	conj	cells,cells
R6203	T9093	T9094	punct	(,4
R6204	T9094	T9092	parataxis	4,cells
R6205	T9095	T9094	punct	),4
R6206	T9096	T9092	prep	with,cells
R6207	T9097	T9098	det	no,beads
R6208	T9098	T9096	pobj	beads,with
R6209	T9099	T9076	punct	;,cells
R6210	T9100	T9076	cc	and,cells
R6211	T9101	T9102	punct	(,III
R6212	T9102	T9103	meta	III,cells
R6213	T9103	T9076	conj	cells,cells
R6214	T9104	T9102	punct	),III
R6215	T9105	T9103	compound	wt,cells
R6216	T9106	T9107	punct	(,1
R6217	T9107	T9103	parataxis	1,cells
R6218	T9108	T9107	punct	),1
R6219	T9109	T9103	acl	labelled,cells
R6220	T9110	T9109	prep	with,labelled
R6221	T9111	T9112	nummod	0.79,μm
R6222	T9112	T9114	compound	μm,beads
R6223	T9113	T9112	punct	-,μm
R6224	T9114	T9110	pobj	beads,with
R6225	T9115	T9103	cc	and,cells
R6226	T9116	T9117	compound	XpdTTD,†XP
R6227	T9117	T9119	compound	†XP,cells
R6228	T9118	T9117	punct	/,†XP
R6229	T9119	T9103	conj	cells,cells
R6230	T9120	T9121	punct	(,5
R6231	T9121	T9119	parataxis	5,cells
R6232	T9122	T9121	punct	),5
R6233	T9123	T9119	prep	with,cells
R6234	T9124	T9125	det	no,beads
R6235	T9125	T9123	pobj	beads,with
R6236	T9126	T9027	punct	.,lines
R6237	T9128	T9129	punct	(,F
R6238	T9129	T9130	meta	F,Quantification
R6239	T9131	T9129	punct	),F
R6240	T9132	T9130	prep	of,Quantification
R6241	T9133	T9134	amod	immunofluorescent,signal
R6242	T9134	T9132	pobj	signal,of
R6243	T9135	T9134	prep	from,signal
R6244	T9136	T9137	advmod	at,50
R6245	T9137	T9139	nummod	50,nuclei
R6246	T9138	T9137	advmod	least,50
R6247	T9139	T9135	pobj	nuclei,from
R6248	T9140	T9139	prep	per,nuclei
R6249	T9141	T9142	compound	cell,line
R6250	T9142	T9140	pobj	line,per
R6251	T9143	T9139	cc	and,nuclei
R6252	T9144	T9145	quantmod	2,6
R6253	T9145	T9147	nummod	6,experiments
R6254	T9146	T9145	punct	–,6
R6255	T9147	T9139	conj	experiments,nuclei
R6256	T9148	T9147	prep	per,experiments
R6257	T9149	T9148	pobj	genotype,per
R6258	T9150	T9130	punct	.,Quantification
R6259	T9152	T9153	nsubjpass	Bars,depicted
R6260	T9154	T9152	acl	representing,Bars
R6261	T9155	T9154	dobj	cells,representing
R6262	T9156	T9155	acl	analysed,cells
R6263	T9157	T9156	prep	on,analysed
R6264	T9158	T9159	det	the,slide
R6265	T9159	T9157	pobj	slide,on
R6266	T9160	T9159	amod	same,slide
R6267	T9161	T9159	amod	microscopic,slide
R6268	T9162	T9153	auxpass	are,depicted
R6269	T9163	T9153	npadvmod	side,depicted
R6270	T9164	T9163	prep	by,side
R6271	T9165	T9164	pobj	side,by
R6272	T9166	T9153	punct	", ",depicted
R6273	T9167	T9153	prep	with,depicted
R6274	T9168	T9167	pobj	wt,with
R6275	T9169	T9168	acl	set,wt
R6276	T9170	T9169	prep	at,set
R6277	T9171	T9172	nummod	100,%
R6278	T9172	T9170	pobj	%,at
R6279	T9173	T9153	punct	.,depicted
R6280	T9175	T9176	det	The,value
R6281	T9176	T9179	nsubj	value,indicates
R6282	T9177	T9176	compound	p,value
R6283	T9178	T9176	punct	-,value
R6284	T9180	T9181	amod	minimum,difference
R6285	T9181	T9179	dobj	difference,indicates
R6286	T9182	T9181	amod	significant,difference
R6287	T9183	T9181	prep	between,difference
R6288	T9184	T9183	pobj	wt,between
R6289	T9185	T9184	cc	and,wt
R6290	T9186	T9187	det	the,lines
R6291	T9187	T9184	conj	lines,wt
R6292	T9188	T9187	amod	indicated,lines
R6293	T9189	T9187	compound	cell,lines
R6294	T9190	T9187	acl	analysed,lines
R6295	T9191	T9190	prep	on,analysed
R6296	T9192	T9193	det	the,slide
R6297	T9193	T9191	pobj	slide,on
R6298	T9194	T9193	amod	same,slide
R6299	T9195	T9193	amod	microscopic,slide
R6300	T9196	T9181	prep	within,difference
R6301	T9197	T9198	nummod	one,experiment
R6302	T9198	T9196	pobj	experiment,within
R6303	T9199	T9179	punct	.,indicates
R2439	T3689	T3688	prep	of,none
R2440	T3690	T3691	det	the,combinations
R2518	T3778	T3779	nsubj	sk,e
R2519	T3779	T3780	ccomp	e,t
R2520	T3781	T3779	dobj	d,e
R2521	T3782	T3781	prep	wh,d
R2522	T3783	T3780	nsubj	e,t
R2523	T3789	T3790	det	h,e
R2524	T3798	T3797	cc	and,†XPCS
R2525	T3799	T3800	compound	Xpd,†XP
R2526	T3800	T3797	conj	†XP,†XPCS
R2527	T3801	T3802	amod	a,l
R2528	T3804	T3805	nsubj	l,e
R2529	T3806	T3805	dobj	les,e
R2530	T3812	T3811	pobj	e,it
R2531	T3817	T3818	amod	re,a
R2532	T3821	T3820	cc	d,e
R2533	T3822	T3820	conj	m,e
R2534	T3826	T3825	compound	RNA,levels
R2535	T3827	T3824	punct	", ",ameliorated
R2536	T3828	T3829	compound	TTD,symptoms
R2537	T3829	T3824	dobj	symptoms,ameliorated
R2538	T3830	T3824	prep	by,ameliorated
R2539	T3831	T3832	amod	increasing,levels
R2540	T3832	T3830	pobj	levels,by
R2541	T3833	T3832	amod	overall,levels
R2542	T3834	T3832	compound	TFIIH,levels
R2543	T3835	T3824	prep	in,ameliorated
R2544	T3836	T3837	nmod	compound,cells
R2545	T3837	T3835	pobj	cells,in
R2546	T3838	T3837	amod	heterozygous,cells
R2547	T3839	T3840	nmod	XpdTTD, †XPCS
R2548	T3840	T3837	nmod	†XPCS,cells
R2549	T3841	T3840	punct	/, †XPCS
R2550	T3842	T3840	cc	and, †XPCS
R2551	T3843	T3844	compound	XpdTTD, †XP
R2552	T3844	T3840	conj	†XP, †XPCS
R2553	T3845	T3844	punct	/, †XP
R2554	T3848	T3849	advmod	Previously,shown
R2555	T3850	T3849	punct	", ",shown
R2556	T3851	T3849	advcl	using,shown
R2557	T3852	T3853	amod	comparative,immunohistochemistry
R2558	T3853	T3851	dobj	immunohistochemistry,using
R2559	T3854	T3849	punct	", ",shown
R2560	T3855	T3849	nsubj	we,shown
R2561	T3856	T3855	cc	and,we
R2562	T3857	T3855	conj	others,we
R2563	T3858	T3849	aux	have,shown
R2564	T3859	T3860	det	an,reduction
R2565	T3860	T3849	dobj	reduction,shown
R2566	T3861	T3862	quantmod	up,70
R2567	T3862	T3864	nummod	70,%
R2568	T3863	T3862	quantmod	to,70
R2569	T3864	T3860	compound	%,reduction
R2570	T3865	T3860	prep	of,reduction
R2571	T3866	T3867	compound	TFIIH,levels
R2812	T4119	T4120	amod	normal,levels
R2813	T4120	T4118	pobj	levels,with
R2814	T4121	T4120	compound	expression,levels
R2815	T4122	T4120	prep	from,levels
R2816	T4123	T4124	det	the,allele
R2817	T4124	T4122	pobj	allele,from
R2818	T4125	T4124	amod	viable,allele
R2819	T4126	T4124	compound	XpdXPCS,allele
R2820	T4127	T4128	punct	(,Table
R2821	T4128	T4088	parataxis	Table,had
R2822	T4129	T4128	nummod	2,Table
R2823	T4130	T4128	cc	and,Table
R2824	T4131	T4132	amod	unpublished,data
R2825	T4132	T4128	conj	data,Table
R2826	T4133	T4128	punct	),Table

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T3067	26-33	SO:0001023	denotes	allelic
T3068	107-120	GO:0071897	denotes	DNA synthesis
T3069	164-177	GO:0032774	denotes	RNA synthesis
T3070	246-249	GO:0006289	denotes	NER
T3071	270-276	SO:0001026	denotes	genome
T3072	277-280	GO:0006289	denotes	NER
T3073	285-310	GO:0006283	denotes	transcription-coupled NER
T3074	322-325	GO:0006289	denotes	NER
T3075	536-539	PR:000007164	denotes	Xpd
T3076	551-554	PR:000007164	denotes	Xpd
T3077	561-568	NCBITaxon:33208	denotes	animals
T3078	593-596	PR:000007164	denotes	Xpd
T3079	716-727	CL:0000057	denotes	fibroblasts
T3080	803-811	NCBITaxon:1	denotes	organism
T3081	813-816	PR:000007164	denotes	Xpd
T3082	948-951	PR:000007164	denotes	Xpd
T3083	1026-1029	PR:000007164	denotes	Xpd
T3084	1035-1041	SO:0001023	denotes	allele
T3085	1045-1048	PR:000007164	denotes	Xpd
T3086	1116-1119	PR:000007164	denotes	Xpd
T8414	2675-2678	PR:000007164	denotes	Xpd
T8415	2923-2929	SO:0001026	denotes	genome
T8416	2930-2936	GO:0006281	denotes	repair
T8417	2969-2972	PR:000007164	denotes	Xpd
T8418	2989-2992	PR:000007164	denotes	Xpd
T8419	3008-3011	PR:000007164	denotes	Xpd
T8420	3031-3034	PR:000007164	denotes	Xpd
T8421	3158-3161	PR:000007164	denotes	Xpd
T8422	3216-3219	PR:000007164	denotes	Xpd
T8423	3252-3280	GO:0006283	denotes	transcription-coupled repair
T8424	3334-3337	PR:000007164	denotes	Xpd
T8425	3354-3357	PR:000007164	denotes	Xpd
T8426	3373-3376	PR:000007164	denotes	Xpd
T8427	3396-3399	PR:000007164	denotes	Xpd
T8428	3476-3484	MOP:0000780	denotes	Incision
T8429	3530-3545	GO:0005675	denotes	TFIIH complexes
T8430	3565-3568	GO:0006289	denotes	NER
T8431	3639-3645	GO:0005675	denotes	TFIIHs
T8432	3658-3661	PR:000007164	denotes	XPD
T8433	3663-3666	PR:000007165	denotes	XPB
T8434	3668-3671	PR:000008317	denotes	p62
T8435	3673-3676	PR:000008320	denotes	p52
T8436	3682-3685	PR:000008318	denotes	p44
T8437	3692-3695	PR:000008319	denotes	p34
T8438	3697-3701	PR:000005265	denotes	cdk7
T8439	3703-3711	PR:000005130	denotes	cyclin H
T8440	3713-3717	PR:000010496	denotes	Mat1
T8441	3723-3725	PR:000008321	denotes	p8
T8442	3755-3758	PR:000007167	denotes	XPG
T8443	3760-3763	PR:000007166	denotes	XPF
T8444	3764-3769	PR:000007163	denotes	ERCC1
T8445	3771-3774	PR:000017494	denotes	XPC
T8446	3775-3781	PR:000013670	denotes	hHR23B
T8447	3783-3786	GO:0005662	denotes	RPA
T8448	3818-3821	GO:0006289	denotes	NER
T8449	4041-4054	GO:0005675	denotes	TFIIH complex
T8450	4131-4134	PR:000007164	denotes	Xpd
T8451	4163-4168	GO:0005675	denotes	TFIIH
T8452	4183-4186	PR:000007164	denotes	Xpd
T8453	4206-4209	PR:000007164	denotes	Xpd
T8454	4243-4246	PR:000007164	denotes	Xpd
T8455	4260-4263	PR:000007164	denotes	Xpd
T8456	4318-4338	PR:000008317	denotes	p62 subunit of TFIIH
T8457	4333-4338	GO:0005675	denotes	TFIIH
T8458	4499-4502	PR:000007164	denotes	Xpd
T8459	4544-4547	PR:000007164	denotes	Xpd
T8460	4629-4632	PR:000007164	denotes	Xpd
T8461	4722-4725	PR:000007164	denotes	Xpd
T8462	4822-4828	GO:0005634	denotes	nuclei
T8405	2338-2343	GO:0005675	denotes	TFIIH
T8406	2372-2375	PR:000007164	denotes	XPD
T8407	2471-2474	PR:000007164	denotes	Xpd
T8408	2493-2496	PR:000007164	denotes	Xpd
T8409	2506-2509	PR:000007164	denotes	Xpd
T8410	2513-2520	SO:0001023	denotes	alleles
T8411	2602-2605	PR:000007164	denotes	Xpd
T8412	2650-2659	GO:0010467	denotes	expressed
T8413	2667-2673	SO:0001023	denotes	allele
T3087	1123-1129	SO:0001023	denotes	allele
T3088	1154-1163	UBERON:0000922	denotes	embryonic
T3089	1255-1258	PR:000007164	denotes	Xpd
T3090	1267-1270	PR:000007164	denotes	Xpd
T3091	1274-1281	SO:0001023	denotes	alleles
T3092	1303-1306	PR:000007164	denotes	XPD
T3093	1310-1313	PR:000007164	denotes	XPD
T3094	1335-1338	PR:000007164	denotes	XPD
T3095	1344-1347	PR:000007164	denotes	XPD
T3096	1354-1359	NCBITaxon:9606	denotes	human
T3097	1452-1455	PR:000007164	denotes	Xpd
T3098	1466-1469	PR:000007164	denotes	XPD
T3099	1482-1487	NCBITaxon:10088	denotes	mouse
T3100	1547-1550	PR:000007164	denotes	Xpd
T3101	1565-1568	PR:000007164	denotes	Xpd
T3102	1646-1652	SO:0001023	denotes	allele
T3103	1736-1739	GO:0006289	denotes	NER
T3104	1764-1767	PR:000007164	denotes	Xpd
T3105	1797-1800	PR:000007164	denotes	Xpd
T3106	1872-1877	GO:0005675	denotes	TFIIH
T3107	1934-1937	PR:000007164	denotes	XPD
T3108	1951-1954	PR:000007164	denotes	XPD
T3109	1969-1972	PR:000007164	denotes	XPD
T3110	2015-2018	GO:0006289	denotes	NER
T3111	2064-2079	GO:0005675	denotes	TFIIH complexes
T3112	2145-2152	SO:0001023	denotes	allelic
T3113	2258-2264	GO:0006281	denotes	repair
T3114	2313-2319	NCBITaxon:33208	denotes	animal
T3115	5165-5166	GO:0006283	denotes	t
T3116	5169-5170	PR:000007164	denotes	X
T3117	5170-5171	PR:000008317	denotes	p
T3118	5171-5172	PR:000005265	denotes	d
T3119	5182-5185	PR:000007164	denotes	Xpd
T3120	5198-5199	PR:000007164	denotes	d
T3121	5201-5202	PR:000007164	denotes	p
T3122	5213-5214	GO:0005634	denotes	e
T3123	5276-5281	GO:0005675	denotes	TFIIH
T3124	5314-5317	PR:000007164	denotes	Xpd
T3125	5332-5335	PR:000007164	denotes	Xpd
T3126	5454-5459	GO:0005675	denotes	TFIIH
T3127	5478-5489	CL:0000057	denotes	fibroblasts
T3128	5585-5595	GO:0010467	denotes	expression
T3129	5613-5616	PR:000007164	denotes	Xpd
T3130	5620-5626	SO:0001023	denotes	allele
T3131	5646-5652	SO:0001023	denotes	allele
T3132	5666-5671	GO:0005675	denotes	TFIIH
T3133	5718-5723	NCBITaxon:10088	denotes	mouse
T3134	5724-5727	PR:000007164	denotes	Xpd
T3135	5735-5746	CL:0000057	denotes	fibroblasts
T3136	5802-5807	NCBITaxon:9606	denotes	human
T3137	5850-5854	SO:0000704	denotes	gene
T3138	5939-5942	PR:000007164	denotes	Xpd
T3139	5981-5991	GO:0010467	denotes	expression
T3140	6012-6015	PR:000007164	denotes	Xpd
T3141	6029-6032	PR:000007164	denotes	Xpd
T3142	6036-6042	SO:0001023	denotes	allele
T3143	6063-6068	GO:0005675	denotes	TFIIH
T3144	6095-6098	PR:000007164	denotes	Xpd
T3145	6325-6330	GO:0005675	denotes	TFIIH
T3146	6463-6473	GO:0010467	denotes	expression
T3147	6521-6524	PR:000007164	denotes	XPD
T3148	6550-6554	UBERON:0001037	denotes	hair
T3149	6585-6588	PR:000007164	denotes	Xpd
T3150	6599-6606	NCBITaxon:33208	denotes	animals
T3151	6625-6629	UBERON:0001037	denotes	hair
T3152	6672-6675	PR:000007164	denotes	Xpd
T3153	6681-6691	GO:0010467	denotes	expression
T3154	6701-6704	PR:000007164	denotes	Xpd
T3155	6713-6720	NCBITaxon:33208	denotes	animals
T3156	6728-6732	UBERON:0001037	denotes	hair
T3157	6758-6768	GO:0010467	denotes	expression
T3158	6792-6795	PR:000007164	denotes	Xpd
T3159	6800-6806	SO:0001023	denotes	allele
T3160	6858-6868	GO:0010467	denotes	expression
T3161	6898-6905	SO:0001023	denotes	alleles
T3162	6960-6964	UBERON:0001037	denotes	hair
T3163	7019-7022	PR:000007164	denotes	Xpd
T3164	7023-7030	SO:0001023	denotes	alleles
T3165	7072-7077	GO:0005675	denotes	TFIIH
T3166	7090-7094	NCBITaxon:10088	denotes	mice

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T3203	1267-1270	PR_EXT:000007164	denotes	Xpd
T3167	0-9	CHEBI_EXT:polyatomic_entity_or_group	denotes	Molecular
T3168	26-33	SO_EXT:0001023	denotes	allelic
T3169	69-77	CL_GO_EXT:cell	denotes	cellular
T3170	107-110	CHEBI_SO_EXT:DNA	denotes	DNA
T3171	107-120	GO:0071897	denotes	DNA synthesis
T3172	164-167	CHEBI_SO_EXT:RNA	denotes	RNA
T3173	164-177	GO:0032774	denotes	RNA synthesis
T3174	246-249	GO:0006289	denotes	NER
T3175	270-276	SO_EXT:0001026	denotes	genome
T3176	277-280	GO:0006289	denotes	NER
T3177	285-310	GO:0006283	denotes	transcription-coupled NER
T3178	322-325	GO:0006289	denotes	NER
T3179	373-381	GO_EXT:reaction_or_response	denotes	response
T3180	536-539	PR_EXT:000007164	denotes	Xpd
T3181	551-554	PR_EXT:000007164	denotes	Xpd
T3182	561-568	NCBITaxon:33208	denotes	animals
T3183	593-596	PR_EXT:000007164	denotes	Xpd
T3184	681-689	CL_GO_EXT:cell	denotes	cellular
T3185	716-727	CL:0000057	denotes	fibroblasts
T3186	803-811	NCBITaxon:1	denotes	organism
T3187	813-816	PR_EXT:000007164	denotes	Xpd
T3188	834-839	CL_GO_EXT:cell	denotes	cells
T3189	929-934	CL_GO_EXT:cell	denotes	cells
T3190	948-951	PR_EXT:000007164	denotes	Xpd
T3191	969-974	CL_GO_EXT:cell	denotes	cells
T3192	1019-1025	GO_EXT:fatality_or_lethality	denotes	lethal
T3193	1026-1029	PR_EXT:000007164	denotes	Xpd
T3194	1035-1041	SO_EXT:0001023	denotes	allele
T3195	1045-1048	PR_EXT:000007164	denotes	Xpd
T3196	1080-1085	CL_GO_EXT:cell	denotes	cells
T3197	1116-1119	PR_EXT:000007164	denotes	Xpd
T3198	1123-1129	SO_EXT:0001023	denotes	allele
T3199	1154-1163	UBERON:0000922	denotes	embryonic
T3200	1168-1176	CL_GO_EXT:cell	denotes	cellular
T3201	1177-1186	GO_EXT:fatality_or_lethality	denotes	lethality
T3202	1255-1258	PR_EXT:000007164	denotes	Xpd
T3204	1274-1281	SO_EXT:0001023	denotes	alleles
T3205	1303-1306	PR_EXT:000007164	denotes	XPD
T3206	1310-1313	PR_EXT:000007164	denotes	XPD
T3207	1335-1338	PR_EXT:000007164	denotes	XPD
T3208	1344-1347	PR_EXT:000007164	denotes	XPD
T3209	1354-1359	NCBITaxon:9606	denotes	human
T3210	1360-1365	CL_GO_EXT:cell	denotes	cells
T3211	1421-1426	CL_GO_EXT:cell	denotes	cells
T3212	1452-1455	PR_EXT:000007164	denotes	Xpd
T3213	1466-1469	PR_EXT:000007164	denotes	XPD
T3214	1482-1487	NCBITaxon:10088	denotes	mouse
T3215	1547-1550	PR_EXT:000007164	denotes	Xpd
T3216	1565-1568	PR_EXT:000007164	denotes	Xpd
T3217	1577-1582	CL_GO_EXT:cell	denotes	cells
T3218	1639-1645	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3219	1646-1652	SO_EXT:0001023	denotes	allele
T3220	1736-1739	GO:0006289	denotes	NER
T3221	1764-1767	PR_EXT:000007164	denotes	Xpd
T3222	1774-1779	CL_GO_EXT:cell	denotes	cells
T3223	1797-1800	PR_EXT:000007164	denotes	Xpd
T3224	1808-1813	CL_GO_EXT:cell	denotes	cells
T3267	5735-5746	CL:0000057	denotes	fibroblasts
T3268	5802-5807	NCBITaxon:9606	denotes	human
T3269	5850-5854	SO_EXT:0000704	denotes	gene
T3270	5903-5905	SO_EXT:wild_type_entity_or_quality	denotes	wt
T3271	5939-5942	PR_EXT:000007164	denotes	Xpd
T3272	5949-5954	CL_GO_EXT:cell	denotes	cells
T3273	5976-5980	CHEBI_SO_EXT:mRNA	denotes	mRNA
T3274	5981-5991	GO:0010467	denotes	expression
T3275	6012-6015	PR_EXT:000007164	denotes	Xpd
T3276	6029-6032	PR_EXT:000007164	denotes	Xpd
T3277	6036-6042	SO_EXT:0001023	denotes	allele
T3278	6063-6068	GO:0005675	denotes	TFIIH
T3279	6082-6084	SO_EXT:wild_type_entity_or_quality	denotes	wt
T3280	6095-6098	PR_EXT:000007164	denotes	Xpd
T3281	6124-6129	CL_GO_EXT:cell	denotes	cells
T3282	6215-6220	CL_GO_EXT:cell	denotes	cells
T3283	6248-6254	SO_EXT:sequence_rescue_process	denotes	rescue
T3284	6325-6330	GO:0005675	denotes	TFIIH
T3285	6458-6462	CHEBI_SO_EXT:mRNA	denotes	mRNA
T3286	6463-6473	GO:0010467	denotes	expression
T3287	6504-6511	SO_EXT:sequence_coding_function	denotes	encoded
T3288	6512-6519	CHEBI_PR_EXT:protein	denotes	protein
T3289	6521-6524	PR_EXT:000007164	denotes	XPD
T3290	6550-6554	UBERON:0001037	denotes	hair
T3291	6585-6588	PR_EXT:000007164	denotes	Xpd
T3292	6599-6606	NCBITaxon:33208	denotes	animals
T3293	6625-6629	UBERON:0001037	denotes	hair
T3294	6672-6675	PR_EXT:000007164	denotes	Xpd
T3295	6681-6691	GO:0010467	denotes	expression
T3296	6701-6704	PR_EXT:000007164	denotes	Xpd
T3297	6713-6720	NCBITaxon:33208	denotes	animals
T3298	6725-6727	SO_EXT:wild_type_entity_or_quality	denotes	wt
T3299	6728-6732	UBERON:0001037	denotes	hair
T3300	6758-6768	GO:0010467	denotes	expression
T3301	6792-6795	PR_EXT:000007164	denotes	Xpd
T3302	6800-6806	SO_EXT:0001023	denotes	allele
T3303	6858-6868	GO:0010467	denotes	expression
T8463	2338-2343	GO:0005675	denotes	TFIIH
T8464	2372-2375	PR_EXT:000007164	denotes	XPD
T8465	2410-2418	CL_GO_EXT:cell	denotes	Cellular
T8466	2450-2456	SO_EXT:sequence_rescue_process	denotes	Rescue
T8467	2471-2474	PR_EXT:000007164	denotes	Xpd
T8468	2493-2496	PR_EXT:000007164	denotes	Xpd
T8469	2506-2509	PR_EXT:000007164	denotes	Xpd
T8470	2513-2520	SO_EXT:0001023	denotes	alleles
T8471	2602-2605	PR_EXT:000007164	denotes	Xpd
T8472	2615-2620	CL_GO_EXT:cell	denotes	cells
T8473	2650-2659	GO:0010467	denotes	expressed
T8474	2667-2673	SO_EXT:0001023	denotes	allele
T8475	2675-2678	PR_EXT:000007164	denotes	Xpd
T8476	2788-2792	CL_GO_EXT:cell	denotes	cell
T8477	2803-2811	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T8478	2923-2929	SO_EXT:0001026	denotes	genome
T8479	2930-2936	GO:0006281	denotes	repair
T8480	2969-2972	PR_EXT:000007164	denotes	Xpd
T8481	2989-2992	PR_EXT:000007164	denotes	Xpd
T8482	3008-3011	PR_EXT:000007164	denotes	Xpd
T8483	3031-3034	PR_EXT:000007164	denotes	Xpd
T8484	3049-3053	CL_GO_EXT:cell	denotes	cell
T8485	3064-3072	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T8486	3158-3161	PR_EXT:000007164	denotes	Xpd
T8487	3216-3219	PR_EXT:000007164	denotes	Xpd
T8488	3252-3280	GO:0006283	denotes	transcription-coupled repair
T8489	3334-3337	PR_EXT:000007164	denotes	Xpd
T8490	3354-3357	PR_EXT:000007164	denotes	Xpd
T8491	3373-3376	PR_EXT:000007164	denotes	Xpd
T8492	3396-3399	PR_EXT:000007164	denotes	Xpd
T8493	3414-3418	CL_GO_EXT:cell	denotes	cell
T8494	3429-3437	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T8495	3476-3484	MOP:0000780	denotes	Incision
T8496	3485-3493	SO_EXT:sequence_deletion_process	denotes	excision
T8497	3522-3529	SO_EXT:sequence_alteration_process	denotes	altered
T8498	3530-3545	GO:0005675	denotes	TFIIH complexes
T8499	3565-3568	GO:0006289	denotes	NER
T8500	3627-3638	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T8501	3639-3645	GO:0005675	denotes	TFIIHs
T8502	3658-3661	PR_EXT:000007164	denotes	XPD
T8503	3663-3666	PR_EXT:000007165	denotes	XPB
T8504	3668-3671	PR_EXT:000008317	denotes	p62
T8505	3673-3676	PR_EXT:000008320	denotes	p52
T8506	3678-3681	CHEBI_SO_EXT:histidine	denotes	His
T8507	3682-3685	PR_EXT:000008318	denotes	p44
T8508	3692-3695	PR_EXT:000008319	denotes	p34
T8509	3697-3701	PR_EXT:000005265	denotes	cdk7
T8510	3703-3711	PR_EXT:000005130	denotes	cyclin H
T8511	3713-3717	PR_EXT:000010496	denotes	Mat1
T8512	3723-3725	PR_EXT:000008321	denotes	p8
T8513	3743-3754	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T8514	3755-3758	PR_EXT:000007167	denotes	XPG
T8515	3760-3763	PR_EXT:000007166	denotes	XPF
T8516	3764-3769	PR_EXT:000007163	denotes	ERCC1
T8517	3771-3774	PR_EXT:000017494	denotes	XPC
T8518	3775-3781	PR_EXT:000013670	denotes	hHR23B
T8519	3783-3786	GO:0005662	denotes	RPA
T8520	3794-3807	CHEBI_EXT:radiolabel_process	denotes	radiolabelled
T8521	3818-3821	GO:0006289	denotes	NER
T8522	3837-3845	SO_EXT:sequence_deletion_process	denotes	excision
T8523	3862-3873	CHEBI_SO_EXT:nucleotide	denotes	nucleotides
T8524	3904-3914	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T8525	3931-3941	GO_EXT:macromolecule_denaturation	denotes	denaturing
T8526	3942-3956	CHEBI_EXT:polyacrylamide	denotes	polyacrylamide
T8527	4041-4054	GO:0005675	denotes	TFIIH complex
T8528	4083-4085	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8529	4131-4134	PR_EXT:000007164	denotes	Xpd
T8530	4163-4168	GO:0005675	denotes	TFIIH
T8531	4183-4186	PR_EXT:000007164	denotes	Xpd
T8532	4206-4209	PR_EXT:000007164	denotes	Xpd
T8533	4243-4246	PR_EXT:000007164	denotes	Xpd
T8534	4260-4263	PR_EXT:000007164	denotes	Xpd
T8535	4271-4276	CL_GO_EXT:cell	denotes	cells
T8536	4318-4338	PR_EXT:000008317	denotes	p62 subunit of TFIIH
T8537	4333-4338	GO:0005675	denotes	TFIIH
T8538	4424-4428	CL_GO_EXT:cell	denotes	cell
T8539	4435-4443	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T8540	4460-4462	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8541	4463-4468	CL_GO_EXT:cell	denotes	cells
T8542	4473-4481	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T8543	4499-4502	PR_EXT:000007164	denotes	Xpd
T8544	4510-4515	CL_GO_EXT:cell	denotes	cells
T8545	4544-4547	PR_EXT:000007164	denotes	Xpd
T8546	4554-4559	CL_GO_EXT:cell	denotes	cells
T8547	4584-4586	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8548	4587-4592	CL_GO_EXT:cell	denotes	cells
T8549	4597-4605	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T8550	4629-4632	PR_EXT:000007164	denotes	Xpd
T8551	4642-4647	CL_GO_EXT:cell	denotes	cells
T8552	4677-4679	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8553	4680-4685	CL_GO_EXT:cell	denotes	cells
T8554	4690-4698	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	labelled
T8555	4722-4725	PR_EXT:000007164	denotes	Xpd
T8556	4733-4738	CL_GO_EXT:cell	denotes	cells
T8557	4822-4828	GO:0005634	denotes	nuclei
T8558	4833-4837	CL_GO_EXT:cell	denotes	cell
T8559	4867-4875	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T8560	4895-4900	CL_GO_EXT:cell	denotes	cells
T8561	4972-4974	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8562	5049-5051	SO_EXT:wild_type_entity_or_quality	denotes	wt
T8563	5070-5074	CL_GO_EXT:cell	denotes	cell
T3225	1865-1871	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3226	1872-1877	GO:0005675	denotes	TFIIH
T3227	1901-1912	SO_EXT:sequence_alteration_entity_or_process	denotes	alterations
T3228	1934-1937	PR_EXT:000007164	denotes	XPD
T3229	1951-1954	PR_EXT:000007164	denotes	XPD
T3230	1969-1972	PR_EXT:000007164	denotes	XPD
T3231	2015-2018	GO:0006289	denotes	NER
T3232	2057-2063	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3233	2064-2079	GO:0005675	denotes	TFIIH complexes
T3234	2145-2152	SO_EXT:0001023	denotes	allelic
T3235	2190-2195	CL_GO_EXT:cell	denotes	cells
T3236	2258-2264	GO:0006281	denotes	repair
T3237	2313-2319	NCBITaxon:33208	denotes	animal
T3238	5165-5166	GO:0006283	denotes	t
T3239	5169-5170	PR_EXT:000007164	denotes	X
T3240	5170-5171	PR_EXT:000008317	denotes	p
T3241	5171-5172	PR_EXT:000005265	denotes	d
T3242	5182-5185	PR_EXT:000007164	denotes	Xpd
T3243	5198-5199	PR_EXT:000007164	denotes	d
T3244	5199-5201	CL_GO_EXT:cell	denotes	es
T3245	5201-5202	PR_EXT:000007164	denotes	p
T3246	5206-5207	CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process	denotes	d
T3247	5208-5209	CL_GO_EXT:cell	denotes	c
T3248	5213-5214	GO:0005634	denotes	e
T3249	5217-5220	CHEBI_SO_EXT:mRNA	denotes	RNA
T3250	5276-5281	GO:0005675	denotes	TFIIH
T3251	5314-5317	PR_EXT:000007164	denotes	Xpd
T3252	5332-5335	PR_EXT:000007164	denotes	Xpd
T3253	5344-5349	CL_GO_EXT:cell	denotes	cells
T3254	5454-5459	GO:0005675	denotes	TFIIH
T3255	5478-5489	CL:0000057	denotes	fibroblasts
T3256	5527-5529	SO_EXT:wild_type_entity_or_quality	denotes	wt
T3257	5585-5595	GO:0010467	denotes	expression
T3258	5599-5603	CHEBI_SO_EXT:mRNA	denotes	mRNA
T3259	5613-5616	PR_EXT:000007164	denotes	Xpd
T3260	5620-5626	SO_EXT:0001023	denotes	allele
T3261	5643-5645	SO_EXT:wild_type_entity_or_quality	denotes	wt
T3262	5646-5652	SO_EXT:0001023	denotes	allele
T3263	5666-5671	GO:0005675	denotes	TFIIH
T3264	5672-5679	CHEBI_PR_EXT:protein	denotes	protein
T3265	5718-5723	NCBITaxon:10088	denotes	mouse
T3266	5724-5727	PR_EXT:000007164	denotes	Xpd
T3304	6891-6897	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T3305	6898-6905	SO_EXT:0001023	denotes	alleles
T3306	6960-6964	UBERON:0001037	denotes	hair
T3307	7019-7022	PR_EXT:000007164	denotes	Xpd
T3308	7023-7030	SO_EXT:0001023	denotes	alleles
T3309	7072-7077	GO:0005675	denotes	TFIIH
T3310	7090-7094	NCBITaxon:10088	denotes	mice
T3311	7099-7104	CL_GO_EXT:cell	denotes	cells

2_test

Id	Subject	Object	Predicate	Lexical cue
17020410-9238033-84795150	1406-1408	9238033	denotes	19
17020410-7825573-84795151	1409-1411	7825573	denotes	25
17020410-16904611-84795152	1520-1522	16904611	denotes	23
17020410-11242112-84795153	5565-5567	11242112	denotes	16
17020410-12393803-84795154	5568-5570	12393803	denotes	17
T77924	1406-1408	9238033	denotes	19
T64659	1409-1411	7825573	denotes	25
T30893	1520-1522	16904611	denotes	23
T9600	5565-5567	11242112	denotes	16
T46580	5568-5570	12393803	denotes	17

PMC:1584416 / 17108-24237 JSONTXT

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2_test

PMC:1584416 / 17108-24237 JSON TXT