Id |
Subject |
Object |
Predicate |
Lexical cue |
T2822 |
1559-1561 |
IN |
denotes |
by |
T2823 |
1562-1570 |
VBG |
denotes |
crossing |
T2824 |
1571-1574 |
DT |
denotes |
the |
T2825 |
1602-1609 |
NNS |
denotes |
animals |
T2826 |
1575-1588 |
VBG |
denotes |
corresponding |
T2827 |
1589-1601 |
JJ |
denotes |
heterozygous |
T2828 |
1609-1610 |
. |
denotes |
. |
T8041 |
11-17 |
NN |
denotes |
Rescue |
T8042 |
18-20 |
IN |
denotes |
of |
T8043 |
21-24 |
NN |
denotes |
TTD |
T8044 |
25-35 |
JJ |
denotes |
Associated |
T8045 |
24-25 |
HYPH |
denotes |
- |
T8046 |
56-64 |
NNS |
denotes |
Features |
T8047 |
36-45 |
JJ |
denotes |
Segmental |
T8048 |
46-55 |
JJ |
denotes |
Progeroid |
T8049 |
65-67 |
IN |
denotes |
in |
T8050 |
68-76 |
JJ |
denotes |
Compound |
T8051 |
104-108 |
NNS |
denotes |
Mice |
T8052 |
77-89 |
JJ |
denotes |
Heterozygous |
T8053 |
90-97 |
NN |
denotes |
Xpd TTD |
T8054 |
98-103 |
NN |
denotes |
†XPCS |
T8055 |
97-98 |
HYPH |
denotes |
/ |
T8056 |
108-209 |
sentence |
denotes |
(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. |
T8057 |
109-110 |
-LRB- |
denotes |
( |
T8058 |
110-111 |
LS |
denotes |
A |
T8059 |
113-124 |
NNS |
denotes |
Photographs |
T8060 |
111-112 |
-RRB- |
denotes |
) |
T8061 |
125-127 |
IN |
denotes |
of |
T8062 |
128-130 |
CD |
denotes |
20 |
T8063 |
131-133 |
NN |
denotes |
mo |
T8064 |
130-131 |
HYPH |
denotes |
- |
T8065 |
134-137 |
JJ |
denotes |
old |
T8066 |
133-134 |
HYPH |
denotes |
- |
T8067 |
204-208 |
NNS |
denotes |
mice |
T8068 |
138-140 |
NN |
denotes |
wt |
T8069 |
140-142 |
, |
denotes |
, |
T8070 |
142-150 |
JJ |
denotes |
compound |
T8071 |
171-176 |
NN |
denotes |
†XPCS |
T8072 |
151-163 |
JJ |
denotes |
heterozygous |
T8073 |
164-170 |
NN |
denotes |
XpdTTD |
T8074 |
170-171 |
HYPH |
denotes |
/ |
T8075 |
176-178 |
, |
denotes |
, |
T8076 |
178-181 |
CC |
denotes |
and |
T8077 |
182-192 |
JJ |
denotes |
homozygous |
T8078 |
200-203 |
NN |
denotes |
TTD |
T8079 |
193-199 |
NN |
denotes |
XpdTTD |
T8080 |
199-200 |
HYPH |
denotes |
/ |
T8081 |
208-209 |
. |
denotes |
. |
T8082 |
209-349 |
sentence |
denotes |
Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice. |
T8083 |
210-214 |
VB |
denotes |
Note |
T8084 |
215-218 |
DT |
denotes |
the |
T8085 |
227-235 |
NN |
denotes |
cachexia |
T8086 |
219-226 |
JJ |
denotes |
extreme |
T8087 |
236-237 |
-LRB- |
denotes |
( |
T8088 |
237-241 |
NN |
denotes |
lack |
T8089 |
242-244 |
IN |
denotes |
of |
T8090 |
245-257 |
JJ |
denotes |
subcutaneous |
T8091 |
258-261 |
NN |
denotes |
fat |
T8092 |
261-262 |
-RRB- |
denotes |
) |
T8093 |
263-265 |
IN |
denotes |
in |
T8094 |
266-269 |
DT |
denotes |
the |
T8095 |
281-286 |
NN |
denotes |
mouse |
T8096 |
270-276 |
NN |
denotes |
XpdTTD |
T8097 |
277-280 |
NN |
denotes |
TTD |
T8098 |
276-277 |
HYPH |
denotes |
/ |
T8099 |
287-290 |
CC |
denotes |
and |
T8100 |
291-294 |
DT |
denotes |
the |
T8101 |
295-302 |
NN |
denotes |
absence |
T8102 |
303-305 |
IN |
denotes |
of |
T8103 |
306-310 |
DT |
denotes |
this |
T8104 |
311-320 |
NN |
denotes |
phenotype |
T8105 |
321-323 |
IN |
denotes |
in |
T8106 |
324-326 |
NN |
denotes |
wt |
T8107 |
344-348 |
NNS |
denotes |
mice |
T8108 |
327-330 |
CC |
denotes |
and |
T8109 |
331-337 |
NN |
denotes |
XpdTTD |
T8110 |
338-343 |
NN |
denotes |
†XPCS |
T8111 |
337-338 |
HYPH |
denotes |
/ |
T8112 |
348-349 |
. |
denotes |
. |
T8113 |
349-422 |
sentence |
denotes |
(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. |
T8114 |
350-351 |
-LRB- |
denotes |
( |
T8115 |
351-352 |
LS |
denotes |
B |
T8116 |
354-365 |
NNS |
denotes |
Radiographs |
T8117 |
352-353 |
-RRB- |
denotes |
) |
T8118 |
366-368 |
IN |
denotes |
of |
T8119 |
369-371 |
CD |
denotes |
20 |
T8120 |
372-374 |
NN |
denotes |
mo |
T8121 |
371-372 |
HYPH |
denotes |
- |
T8122 |
375-378 |
JJ |
denotes |
old |
T8123 |
374-375 |
HYPH |
denotes |
- |
T8124 |
417-421 |
NNS |
denotes |
mice |
T8125 |
379-383 |
JJ |
denotes |
male |
T8126 |
384-386 |
NN |
denotes |
wt |
T8127 |
386-388 |
, |
denotes |
, |
T8128 |
388-394 |
NN |
denotes |
XpdTTD |
T8129 |
395-400 |
NN |
denotes |
†XPCS |
T8130 |
394-395 |
HYPH |
denotes |
/ |
T8131 |
400-402 |
, |
denotes |
, |
T8132 |
402-405 |
CC |
denotes |
and |
T8133 |
406-412 |
NN |
denotes |
XpdTTD |
T8134 |
413-416 |
NN |
denotes |
TTD |
T8135 |
412-413 |
HYPH |
denotes |
/ |
T8136 |
421-422 |
. |
denotes |
. |
T8137 |
422-632 |
sentence |
denotes |
Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). |
T8138 |
423-429 |
VBG |
denotes |
Ageing |
T8139 |
441-445 |
NNS |
denotes |
mice |
T8140 |
430-436 |
NN |
denotes |
XpdTTD |
T8141 |
437-440 |
NN |
denotes |
TTD |
T8142 |
436-437 |
HYPH |
denotes |
/ |
T8143 |
446-453 |
VBP |
denotes |
develop |
T8144 |
454-462 |
NN |
denotes |
kyphosis |
T8145 |
463-464 |
-LRB- |
denotes |
( |
T8146 |
464-473 |
NN |
denotes |
curvature |
T8147 |
474-476 |
IN |
denotes |
of |
T8148 |
477-480 |
DT |
denotes |
the |
T8149 |
488-494 |
NN |
denotes |
column |
T8150 |
481-487 |
JJ |
denotes |
spinal |
T8151 |
494-495 |
-RRB- |
denotes |
) |
T8152 |
496-499 |
CC |
denotes |
and |
T8153 |
500-509 |
NN |
denotes |
reduction |
T8154 |
510-512 |
IN |
denotes |
of |
T8155 |
513-517 |
NN |
denotes |
bone |
T8156 |
518-525 |
NN |
denotes |
mineral |
T8157 |
526-533 |
NN |
denotes |
density |
T8158 |
534-536 |
IN |
denotes |
as |
T8159 |
537-542 |
VBN |
denotes |
shown |
T8160 |
543-545 |
IN |
denotes |
in |
T8161 |
546-549 |
DT |
denotes |
the |
T8162 |
554-561 |
NN |
denotes |
segment |
T8163 |
550-551 |
CD |
denotes |
6 |
T8164 |
552-553 |
CD |
denotes |
8 |
T8165 |
551-552 |
SYM |
denotes |
– |
T8166 |
562-564 |
IN |
denotes |
of |
T8167 |
565-568 |
DT |
denotes |
the |
T8168 |
574-583 |
NNS |
denotes |
vertebrae |
T8169 |
569-573 |
NN |
denotes |
tail |
T8170 |
584-591 |
VBN |
denotes |
counted |
T8171 |
592-596 |
IN |
denotes |
from |
T8172 |
597-600 |
DT |
denotes |
the |
T8173 |
601-607 |
NN |
denotes |
pelvis |
T8174 |
608-609 |
-LRB- |
denotes |
( |
T8175 |
609-612 |
VB |
denotes |
see |
T8176 |
613-618 |
JJ |
denotes |
close |
T8177 |
618-619 |
HYPH |
denotes |
- |
T8178 |
619-621 |
RP |
denotes |
up |
T8179 |
622-624 |
IN |
denotes |
at |
T8180 |
625-630 |
NN |
denotes |
right |
T8181 |
630-631 |
-RRB- |
denotes |
) |
T8182 |
631-632 |
. |
denotes |
. |
T8183 |
632-697 |
sentence |
denotes |
Note the absence of these features in the XpdTTD / † XPCS mouse. |
T8184 |
633-637 |
VB |
denotes |
Note |
T8185 |
638-641 |
DT |
denotes |
the |
T8186 |
642-649 |
NN |
denotes |
absence |
T8187 |
650-652 |
IN |
denotes |
of |
T8188 |
653-658 |
DT |
denotes |
these |
T8189 |
659-667 |
NNS |
denotes |
features |
T8190 |
668-670 |
IN |
denotes |
in |
T8191 |
671-674 |
DT |
denotes |
the |
T8192 |
691-696 |
NN |
denotes |
mouse |
T8193 |
675-682 |
NN |
denotes |
XpdTTD |
T8194 |
683-690 |
NN |
denotes |
† XPCS |
T8195 |
682-683 |
HYPH |
denotes |
/ |
T8196 |
696-697 |
. |
denotes |
. |
T8197 |
697-850 |
sentence |
denotes |
(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. |
T8198 |
698-699 |
-LRB- |
denotes |
( |
T8199 |
699-700 |
LS |
denotes |
C |
T8200 |
702-716 |
NN |
denotes |
Quantification |
T8201 |
700-701 |
-RRB- |
denotes |
) |
T8202 |
717-719 |
IN |
denotes |
of |
T8203 |
720-728 |
JJ |
denotes |
relative |
T8204 |
742-749 |
NN |
denotes |
density |
T8205 |
729-733 |
NN |
denotes |
bone |
T8206 |
734-741 |
NN |
denotes |
mineral |
T8207 |
750-752 |
IN |
denotes |
of |
T8208 |
753-757 |
NN |
denotes |
tail |
T8209 |
758-767 |
NNS |
denotes |
vertebrae |
T8210 |
768-772 |
IN |
denotes |
from |
T8211 |
773-775 |
CD |
denotes |
20 |
T8212 |
776-778 |
NN |
denotes |
mo |
T8213 |
775-776 |
HYPH |
denotes |
- |
T8214 |
779-782 |
JJ |
denotes |
old |
T8215 |
778-779 |
HYPH |
denotes |
- |
T8216 |
845-849 |
NNS |
denotes |
mice |
T8217 |
783-787 |
JJ |
denotes |
male |
T8218 |
788-790 |
NN |
denotes |
wt |
T8219 |
791-792 |
-LRB- |
denotes |
( |
T8220 |
796-797 |
CD |
denotes |
3 |
T8221 |
792-793 |
NN |
denotes |
n |
T8222 |
794-795 |
SYM |
denotes |
= |
T8223 |
797-798 |
-RRB- |
denotes |
) |
T8224 |
798-800 |
, |
denotes |
, |
T8225 |
800-806 |
NN |
denotes |
XpdTTD |
T8226 |
807-812 |
NN |
denotes |
†XPCS |
T8227 |
806-807 |
HYPH |
denotes |
/ |
T8228 |
813-814 |
-LRB- |
denotes |
( |
T8229 |
818-819 |
CD |
denotes |
4 |
T8230 |
814-815 |
NN |
denotes |
n |
T8231 |
816-817 |
SYM |
denotes |
= |
T8232 |
819-820 |
-RRB- |
denotes |
) |
T8233 |
820-822 |
, |
denotes |
, |
T8234 |
822-825 |
CC |
denotes |
and |
T8235 |
826-832 |
NN |
denotes |
XpdTTD |
T8236 |
833-836 |
NN |
denotes |
TTD |
T8237 |
832-833 |
HYPH |
denotes |
/ |
T8238 |
837-838 |
-LRB- |
denotes |
( |
T8239 |
842-843 |
CD |
denotes |
3 |
T8240 |
838-839 |
NN |
denotes |
n |
T8241 |
840-841 |
SYM |
denotes |
= |
T8242 |
843-844 |
-RRB- |
denotes |
) |
T8243 |
849-850 |
. |
denotes |
. |
T8244 |
850-931 |
sentence |
denotes |
The p-values indicate the significance of the difference relative to XpdTTD/TTD. |
T8245 |
851-854 |
DT |
denotes |
The |
T8246 |
857-863 |
NNS |
denotes |
values |
T8247 |
855-856 |
NN |
denotes |
p |
T8248 |
856-857 |
HYPH |
denotes |
- |
T8249 |
864-872 |
VBP |
denotes |
indicate |
T8250 |
873-876 |
DT |
denotes |
the |
T8251 |
877-889 |
NN |
denotes |
significance |
T8252 |
890-892 |
IN |
denotes |
of |
T8253 |
893-896 |
DT |
denotes |
the |
T8254 |
897-907 |
NN |
denotes |
difference |
T8255 |
908-916 |
JJ |
denotes |
relative |
T8256 |
917-919 |
IN |
denotes |
to |
T8257 |
920-926 |
NN |
denotes |
XpdTTD |
T8258 |
927-930 |
NN |
denotes |
TTD |
T8259 |
926-927 |
HYPH |
denotes |
/ |
T8260 |
930-931 |
. |
denotes |
. |
T8261 |
931-956 |
sentence |
denotes |
Error bars indicate SEM. |
T8262 |
932-937 |
NN |
denotes |
Error |
T8263 |
938-942 |
NNS |
denotes |
bars |
T8264 |
943-951 |
VBP |
denotes |
indicate |
T8265 |
952-955 |
NN |
denotes |
SEM |
T8266 |
955-956 |
. |
denotes |
. |
T8267 |
956-1002 |
sentence |
denotes |
(D) Body weight curves as a function of time. |
T8268 |
957-958 |
-LRB- |
denotes |
( |
T8269 |
958-959 |
LS |
denotes |
D |
T8270 |
973-979 |
NNS |
denotes |
curves |
T8271 |
959-960 |
-RRB- |
denotes |
) |
T8272 |
961-965 |
NN |
denotes |
Body |
T8273 |
966-972 |
NN |
denotes |
weight |
T8274 |
980-982 |
IN |
denotes |
as |
T8275 |
983-984 |
DT |
denotes |
a |
T8276 |
985-993 |
NN |
denotes |
function |
T8277 |
994-996 |
IN |
denotes |
of |
T8278 |
997-1001 |
NN |
denotes |
time |
T8279 |
1001-1002 |
. |
denotes |
. |
T8280 |
1002-1124 |
sentence |
denotes |
Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. |
T8281 |
1003-1007 |
VB |
denotes |
Note |
T8282 |
1008-1012 |
IN |
denotes |
that |
T8283 |
1072-1079 |
VBN |
denotes |
rescued |
T8284 |
1013-1016 |
DT |
denotes |
the |
T8285 |
1031-1039 |
NN |
denotes |
cachexia |
T8286 |
1017-1020 |
NN |
denotes |
age |
T8287 |
1021-1030 |
JJ |
denotes |
dependent |
T8288 |
1020-1021 |
HYPH |
denotes |
- |
T8289 |
1040-1048 |
VBN |
denotes |
observed |
T8290 |
1049-1051 |
IN |
denotes |
in |
T8291 |
1052-1058 |
NN |
denotes |
XpdTTD |
T8292 |
1059-1062 |
NN |
denotes |
TTD |
T8293 |
1058-1059 |
HYPH |
denotes |
/ |
T8294 |
1063-1067 |
NNS |
denotes |
mice |
T8295 |
1068-1071 |
VBD |
denotes |
was |
T8296 |
1080-1082 |
IN |
denotes |
in |
T8297 |
1083-1087 |
CC |
denotes |
both |
T8298 |
1088-1092 |
JJ |
denotes |
male |
T8299 |
1119-1123 |
NNS |
denotes |
mice |
T8300 |
1093-1096 |
CC |
denotes |
and |
T8301 |
1097-1103 |
JJ |
denotes |
female |
T8302 |
1104-1111 |
NN |
denotes |
XpdTTD |
T8303 |
1112-1118 |
NN |
denotes |
†XPCS |
T8304 |
1111-1112 |
HYPH |
denotes |
/ |
T8305 |
1123-1124 |
. |
denotes |
. |
T8306 |
1124-1278 |
sentence |
denotes |
Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. |
T8307 |
1125-1136 |
JJ |
denotes |
Significant |
T8308 |
1137-1148 |
NNS |
denotes |
differences |
T8309 |
1221-1229 |
VBN |
denotes |
observed |
T8310 |
1149-1156 |
IN |
denotes |
between |
T8311 |
1157-1159 |
NN |
denotes |
wt |
T8312 |
1160-1163 |
CC |
denotes |
and |
T8313 |
1164-1170 |
NN |
denotes |
XpdTTD |
T8314 |
1171-1174 |
NN |
denotes |
TTD |
T8315 |
1170-1171 |
HYPH |
denotes |
/ |
T8316 |
1175-1178 |
CC |
denotes |
but |
T8317 |
1179-1182 |
RB |
denotes |
not |
T8318 |
1183-1190 |
IN |
denotes |
between |
T8319 |
1191-1193 |
NN |
denotes |
wt |
T8320 |
1211-1215 |
NNS |
denotes |
mice |
T8321 |
1194-1197 |
CC |
denotes |
and |
T8322 |
1198-1204 |
NN |
denotes |
XpdTTD |
T8323 |
1205-1210 |
NN |
denotes |
†XPCS |
T8324 |
1204-1205 |
HYPH |
denotes |
/ |
T8325 |
1216-1220 |
VBD |
denotes |
were |
T8326 |
1230-1232 |
IN |
denotes |
at |
T8327 |
1233-1234 |
CD |
denotes |
9 |
T8328 |
1242-1244 |
NNS |
denotes |
mo |
T8329 |
1235-1238 |
CC |
denotes |
and |
T8330 |
1239-1241 |
CD |
denotes |
18 |
T8331 |
1245-1247 |
IN |
denotes |
of |
T8332 |
1248-1251 |
NN |
denotes |
age |
T8333 |
1252-1254 |
IN |
denotes |
as |
T8334 |
1255-1264 |
VBN |
denotes |
indicated |
T8335 |
1265-1267 |
IN |
denotes |
by |
T8336 |
1268-1277 |
NNS |
denotes |
asterisks |
T8337 |
1277-1278 |
. |
denotes |
. |
T8338 |
1278-1303 |
sentence |
denotes |
Error bars indicate SEM. |
T8339 |
1279-1284 |
NN |
denotes |
Error |
T8340 |
1285-1289 |
NNS |
denotes |
bars |
T8341 |
1290-1298 |
VBP |
denotes |
indicate |
T8342 |
1299-1302 |
NN |
denotes |
SEM |
T8343 |
1302-1303 |
. |
denotes |
. |
T9241 |
1313-1324 |
JJ |
denotes |
Pleiotropic |
T9242 |
1339-1346 |
NNS |
denotes |
Effects |
T9243 |
1325-1328 |
NN |
denotes |
Xpd |
T9244 |
1329-1338 |
JJ |
denotes |
Biallelic |
T9245 |
1347-1349 |
IN |
denotes |
in |
T9246 |
1350-1354 |
NNS |
denotes |
Mice |
T9247 |
1355-1358 |
CC |
denotes |
and |
T9248 |
1359-1364 |
NNS |
denotes |
Cells |
T2791 |
0-1610 |
sentence |
denotes |
Figure 3 Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice
(A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.
(B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse.
(C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM.
(D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM.
Table 2 Pleiotropic Xpd Biallelic Effects in Mice and Cells To determine whether the homozygous lethal Xpd†XPCS allele was unique in its ability to ameliorate symptoms associated with the XpdTTD allele, we generated compound heterozygous XpdTTD/†XP mice by crossing the corresponding heterozygous animals. |
T2792 |
1365-1367 |
TO |
denotes |
To |
T2793 |
1368-1377 |
VB |
denotes |
determine |
T2794 |
1511-1520 |
VBD |
denotes |
generated |
T2795 |
1378-1385 |
IN |
denotes |
whether |
T2796 |
1424-1427 |
VBD |
denotes |
was |
T2797 |
1386-1389 |
DT |
denotes |
the |
T2798 |
1417-1423 |
NN |
denotes |
allele |
T2799 |
1390-1400 |
JJ |
denotes |
homozygous |
T2800 |
1401-1407 |
JJ |
denotes |
lethal |
T2801 |
1408-1416 |
NN |
denotes |
Xpd†XPCS |
T2802 |
1428-1434 |
JJ |
denotes |
unique |
T2803 |
1435-1437 |
IN |
denotes |
in |
T2804 |
1438-1441 |
PRP$ |
denotes |
its |
T2805 |
1442-1449 |
NN |
denotes |
ability |
T2806 |
1450-1452 |
TO |
denotes |
to |
T2807 |
1453-1463 |
VB |
denotes |
ameliorate |
T2808 |
1464-1472 |
NNS |
denotes |
symptoms |
T2809 |
1473-1483 |
VBN |
denotes |
associated |
T2810 |
1484-1488 |
IN |
denotes |
with |
T2811 |
1489-1492 |
DT |
denotes |
the |
T2812 |
1500-1506 |
NN |
denotes |
allele |
T2813 |
1493-1499 |
NN |
denotes |
XpdTTD |
T2814 |
1506-1508 |
, |
denotes |
, |
T2815 |
1508-1510 |
PRP |
denotes |
we |
T2816 |
1521-1529 |
NN |
denotes |
compound |
T2817 |
1554-1558 |
NNS |
denotes |
mice |
T2818 |
1530-1542 |
JJ |
denotes |
heterozygous |
T2819 |
1543-1549 |
NN |
denotes |
XpdTTD |
T2820 |
1550-1553 |
NN |
denotes |
†XP |
T2821 |
1549-1550 |
HYPH |
denotes |
/ |
R1923 |
T2806 |
T2807 |
aux |
to,ameliorate |
R1924 |
T2807 |
T2805 |
acl |
ameliorate,ability |
R1925 |
T2808 |
T2807 |
dobj |
symptoms,ameliorate |
R1926 |
T2809 |
T2808 |
acl |
associated,symptoms |
R1927 |
T2810 |
T2809 |
prep |
with,associated |
R1928 |
T2811 |
T2812 |
det |
the,allele |
R1929 |
T2812 |
T2810 |
pobj |
allele,with |
R1930 |
T2813 |
T2812 |
compound |
XpdTTD,allele |
R1931 |
T2814 |
T2794 |
punct |
", ",generated |
R1932 |
T2815 |
T2794 |
nsubj |
we,generated |
R1933 |
T2816 |
T2817 |
nmod |
compound,mice |
R1934 |
T2817 |
T2794 |
dobj |
mice,generated |
R1935 |
T2818 |
T2817 |
amod |
heterozygous,mice |
R1936 |
T2819 |
T2820 |
compound |
XpdTTD,†XP |
R1937 |
T2820 |
T2817 |
compound |
†XP,mice |
R1938 |
T2821 |
T2820 |
punct |
/,†XP |
R1939 |
T2822 |
T2794 |
prep |
by,generated |
R1940 |
T2823 |
T2822 |
pcomp |
crossing,by |
R1941 |
T2824 |
T2825 |
det |
the,animals |
R1942 |
T2825 |
T2823 |
dobj |
animals,crossing |
R1943 |
T2826 |
T2825 |
amod |
corresponding,animals |
R1944 |
T2827 |
T2825 |
amod |
heterozygous,animals |
R1945 |
T2828 |
T2794 |
punct |
.,generated |
R5429 |
T8042 |
T8041 |
prep |
of,Rescue |
R5430 |
T8043 |
T8044 |
npadvmod |
TTD,Associated |
R5431 |
T8044 |
T8046 |
amod |
Associated,Features |
R5432 |
T8045 |
T8044 |
punct |
-,Associated |
R5433 |
T8046 |
T8042 |
pobj |
Features,of |
R5434 |
T8047 |
T8046 |
amod |
Segmental,Features |
R5435 |
T8048 |
T8046 |
amod |
Progeroid,Features |
R5436 |
T8049 |
T8046 |
prep |
in,Features |
R5437 |
T8050 |
T8051 |
amod |
Compound,Mice |
R5438 |
T8051 |
T8049 |
pobj |
Mice,in |
R5439 |
T8052 |
T8051 |
amod |
Heterozygous,Mice |
R5440 |
T8053 |
T8054 |
compound |
Xpd TTD,†XPCS |
R5441 |
T8054 |
T8051 |
compound |
†XPCS,Mice |
R5442 |
T8055 |
T8054 |
punct |
/,†XPCS |
R5443 |
T8057 |
T8058 |
punct |
(,A |
R5444 |
T8058 |
T8059 |
meta |
A,Photographs |
R5445 |
T8060 |
T8058 |
punct |
),A |
R5446 |
T8061 |
T8059 |
prep |
of,Photographs |
R5447 |
T8062 |
T8063 |
nummod |
20,mo |
R5448 |
T8063 |
T8065 |
npadvmod |
mo,old |
R5449 |
T8064 |
T8063 |
punct |
-,mo |
R5450 |
T8065 |
T8067 |
amod |
old,mice |
R5451 |
T8066 |
T8065 |
punct |
-,old |
R5452 |
T8067 |
T8061 |
pobj |
mice,of |
R5453 |
T8068 |
T8067 |
nmod |
wt,mice |
R5454 |
T8069 |
T8068 |
punct |
", ",wt |
R5455 |
T8070 |
T8071 |
amod |
compound,†XPCS |
R5456 |
T8071 |
T8068 |
conj |
†XPCS,wt |
R5457 |
T8072 |
T8071 |
amod |
heterozygous,†XPCS |
R5458 |
T8073 |
T8071 |
compound |
XpdTTD,†XPCS |
R5459 |
T8074 |
T8071 |
punct |
/,†XPCS |
R5460 |
T8075 |
T8071 |
punct |
", ",†XPCS |
R5461 |
T8076 |
T8071 |
cc |
and,†XPCS |
R5462 |
T8077 |
T8078 |
amod |
homozygous,TTD |
R5463 |
T8078 |
T8071 |
conj |
TTD,†XPCS |
R5464 |
T8079 |
T8078 |
compound |
XpdTTD,TTD |
R5465 |
T8080 |
T8078 |
punct |
/,TTD |
R5466 |
T8081 |
T8059 |
punct |
.,Photographs |
R5467 |
T8084 |
T8085 |
det |
the,cachexia |
R5468 |
T8085 |
T8083 |
dobj |
cachexia,Note |
R5469 |
T8086 |
T8085 |
amod |
extreme,cachexia |
R5470 |
T8087 |
T8085 |
punct |
(,cachexia |
R5471 |
T8088 |
T8085 |
appos |
lack,cachexia |
R5472 |
T8089 |
T8088 |
prep |
of,lack |
R5473 |
T8090 |
T8091 |
amod |
subcutaneous,fat |
R5474 |
T8091 |
T8089 |
pobj |
fat,of |
R5475 |
T8092 |
T8085 |
punct |
),cachexia |
R5476 |
T8093 |
T8085 |
prep |
in,cachexia |
R5477 |
T8094 |
T8095 |
det |
the,mouse |
R5478 |
T8095 |
T8093 |
pobj |
mouse,in |
R5479 |
T8096 |
T8097 |
compound |
XpdTTD,TTD |
R5480 |
T8097 |
T8095 |
compound |
TTD,mouse |
R5481 |
T8098 |
T8097 |
punct |
/,TTD |
R5482 |
T8099 |
T8083 |
cc |
and,Note |
R5483 |
T8100 |
T8101 |
det |
the,absence |
R5484 |
T8101 |
T8083 |
conj |
absence,Note |
R5485 |
T8102 |
T8101 |
prep |
of,absence |
R5486 |
T8103 |
T8104 |
det |
this,phenotype |
R5487 |
T8104 |
T8102 |
pobj |
phenotype,of |
R5488 |
T8105 |
T8101 |
prep |
in,absence |
R5489 |
T8106 |
T8107 |
nmod |
wt,mice |
R5490 |
T8107 |
T8105 |
pobj |
mice,in |
R5491 |
T8108 |
T8106 |
cc |
and,wt |
R5492 |
T8109 |
T8110 |
compound |
XpdTTD,†XPCS |
R5493 |
T8110 |
T8106 |
conj |
†XPCS,wt |
R5494 |
T8111 |
T8110 |
punct |
/,†XPCS |
R5495 |
T8112 |
T8083 |
punct |
.,Note |
R5496 |
T8114 |
T8115 |
punct |
(,B |
R5497 |
T8115 |
T8116 |
meta |
B,Radiographs |
R5498 |
T8117 |
T8115 |
punct |
),B |
R5499 |
T8118 |
T8116 |
prep |
of,Radiographs |
R5500 |
T8119 |
T8120 |
nummod |
20,mo |
R5501 |
T8120 |
T8122 |
npadvmod |
mo,old |
R5502 |
T8121 |
T8120 |
punct |
-,mo |
R5503 |
T8122 |
T8124 |
amod |
old,mice |
R5504 |
T8123 |
T8122 |
punct |
-,old |
R5505 |
T8124 |
T8118 |
pobj |
mice,of |
R5506 |
T8125 |
T8124 |
amod |
male,mice |
R5507 |
T8126 |
T8124 |
nmod |
wt,mice |
R5508 |
T8127 |
T8126 |
punct |
", ",wt |
R5509 |
T8128 |
T8129 |
compound |
XpdTTD,†XPCS |
R5510 |
T8129 |
T8126 |
conj |
†XPCS,wt |
R5511 |
T8130 |
T8129 |
punct |
/,†XPCS |
R5512 |
T8131 |
T8129 |
punct |
", ",†XPCS |
R5513 |
T8132 |
T8129 |
cc |
and,†XPCS |
R5514 |
T8133 |
T8134 |
compound |
XpdTTD,TTD |
R5515 |
T8134 |
T8129 |
conj |
TTD,†XPCS |
R5516 |
T8135 |
T8134 |
punct |
/,TTD |
R5517 |
T8136 |
T8116 |
punct |
.,Radiographs |
R5518 |
T8138 |
T8139 |
amod |
Ageing,mice |
R5519 |
T8139 |
T8143 |
nsubj |
mice,develop |
R5520 |
T8140 |
T8141 |
compound |
XpdTTD,TTD |
R5521 |
T8141 |
T8139 |
compound |
TTD,mice |
R5522 |
T8142 |
T8141 |
punct |
/,TTD |
R5523 |
T8144 |
T8143 |
dobj |
kyphosis,develop |
R5524 |
T8145 |
T8144 |
punct |
(,kyphosis |
R5525 |
T8146 |
T8144 |
appos |
curvature,kyphosis |
R5526 |
T8147 |
T8146 |
prep |
of,curvature |
R5527 |
T8148 |
T8149 |
det |
the,column |
R5528 |
T8149 |
T8147 |
pobj |
column,of |
R5529 |
T8150 |
T8149 |
amod |
spinal,column |
R5530 |
T8151 |
T8144 |
punct |
),kyphosis |
R5531 |
T8152 |
T8144 |
cc |
and,kyphosis |
R5532 |
T8153 |
T8144 |
conj |
reduction,kyphosis |
R5533 |
T8154 |
T8153 |
prep |
of,reduction |
R5534 |
T8155 |
T8156 |
compound |
bone,mineral |
R5535 |
T8156 |
T8157 |
compound |
mineral,density |
R5536 |
T8157 |
T8154 |
pobj |
density,of |
R5537 |
T8158 |
T8159 |
mark |
as,shown |
R5538 |
T8159 |
T8143 |
advcl |
shown,develop |
R5539 |
T8160 |
T8159 |
prep |
in,shown |
R5540 |
T8161 |
T8162 |
det |
the,segment |
R5541 |
T8162 |
T8160 |
pobj |
segment,in |
R5542 |
T8163 |
T8164 |
quantmod |
6,8 |
R5543 |
T8164 |
T8162 |
nummod |
8,segment |
R5544 |
T8165 |
T8164 |
punct |
–,8 |
R5545 |
T8166 |
T8162 |
prep |
of,segment |
R5546 |
T8167 |
T8168 |
det |
the,vertebrae |
R5547 |
T8168 |
T8166 |
pobj |
vertebrae,of |
R5548 |
T8169 |
T8168 |
compound |
tail,vertebrae |
R5549 |
T8170 |
T8162 |
acl |
counted,segment |
R5550 |
T8171 |
T8170 |
prep |
from,counted |
R5551 |
T8172 |
T8173 |
det |
the,pelvis |
R5552 |
T8173 |
T8171 |
pobj |
pelvis,from |
R5553 |
T8174 |
T8175 |
punct |
(,see |
R5554 |
T8175 |
T8143 |
parataxis |
see,develop |
R5555 |
T8176 |
T8175 |
dobj |
close,see |
R5556 |
T8177 |
T8176 |
punct |
-,close |
R5557 |
T8178 |
T8176 |
prt |
up,close |
R5558 |
T8179 |
T8176 |
prep |
at,close |
R5559 |
T8180 |
T8179 |
pobj |
right,at |
R5560 |
T8181 |
T8175 |
punct |
),see |
R5561 |
T8182 |
T8143 |
punct |
.,develop |
R5562 |
T8185 |
T8186 |
det |
the,absence |
R5563 |
T8186 |
T8184 |
dobj |
absence,Note |
R5564 |
T8187 |
T8186 |
prep |
of,absence |
R5565 |
T8188 |
T8189 |
det |
these,features |
R5566 |
T8189 |
T8187 |
pobj |
features,of |
R5567 |
T8190 |
T8186 |
prep |
in,absence |
R5568 |
T8191 |
T8192 |
det |
the,mouse |
R5569 |
T8192 |
T8190 |
pobj |
mouse,in |
R5570 |
T8193 |
T8194 |
compound |
XpdTTD , † XPCS |
R5571 |
T8194 |
T8192 |
compound |
† XPCS,mouse |
R5572 |
T8195 |
T8194 |
punct |
/, † XPCS |
R5573 |
T8196 |
T8184 |
punct |
.,Note |
R5574 |
T8198 |
T8199 |
punct |
(,C |
R5575 |
T8199 |
T8200 |
meta |
C,Quantification |
R5576 |
T8201 |
T8199 |
punct |
),C |
R5577 |
T8202 |
T8200 |
prep |
of,Quantification |
R5578 |
T8203 |
T8204 |
amod |
relative,density |
R5579 |
T8204 |
T8202 |
pobj |
density,of |
R5580 |
T8205 |
T8206 |
compound |
bone,mineral |
R5581 |
T8206 |
T8204 |
compound |
mineral,density |
R5582 |
T8207 |
T8204 |
prep |
of,density |
R5583 |
T8208 |
T8209 |
compound |
tail,vertebrae |
R5584 |
T8209 |
T8207 |
pobj |
vertebrae,of |
R5585 |
T8210 |
T8209 |
prep |
from,vertebrae |
R5586 |
T8211 |
T8212 |
nummod |
20,mo |
R5587 |
T8212 |
T8214 |
npadvmod |
mo,old |
R5588 |
T8213 |
T8212 |
punct |
-,mo |
R5589 |
T8214 |
T8216 |
amod |
old,mice |
R5590 |
T8215 |
T8214 |
punct |
-,old |
R5591 |
T8216 |
T8210 |
pobj |
mice,from |
R5592 |
T8217 |
T8216 |
amod |
male,mice |
R5593 |
T8218 |
T8216 |
nmod |
wt,mice |
R5594 |
T8219 |
T8220 |
punct |
(,3 |
R5595 |
T8220 |
T8218 |
parataxis |
3,wt |
R5596 |
T8221 |
T8220 |
nsubj |
n,3 |
R5597 |
T8222 |
T8220 |
punct |
=,3 |
R5598 |
T8223 |
T8220 |
punct |
),3 |
R5599 |
T8224 |
T8218 |
punct |
", ",wt |
R5600 |
T8225 |
T8226 |
compound |
XpdTTD,†XPCS |
R5601 |
T8226 |
T8218 |
conj |
†XPCS,wt |
R5602 |
T8227 |
T8226 |
punct |
/,†XPCS |
R5603 |
T8228 |
T8229 |
punct |
(,4 |
R5604 |
T8229 |
T8226 |
parataxis |
4,†XPCS |
R5605 |
T8230 |
T8229 |
nsubj |
n,4 |
R5606 |
T8231 |
T8229 |
punct |
=,4 |
R5607 |
T8232 |
T8229 |
punct |
),4 |
R5608 |
T8233 |
T8226 |
punct |
", ",†XPCS |
R5609 |
T8234 |
T8226 |
cc |
and,†XPCS |
R5610 |
T8235 |
T8236 |
compound |
XpdTTD,TTD |
R5611 |
T8236 |
T8226 |
conj |
TTD,†XPCS |
R5612 |
T8237 |
T8236 |
punct |
/,TTD |
R5613 |
T8238 |
T8239 |
punct |
(,3 |
R5614 |
T8239 |
T8236 |
parataxis |
3,TTD |
R5615 |
T8240 |
T8239 |
nsubj |
n,3 |
R5616 |
T8241 |
T8239 |
punct |
=,3 |
R5617 |
T8242 |
T8239 |
punct |
),3 |
R5618 |
T8243 |
T8200 |
punct |
.,Quantification |
R5619 |
T8245 |
T8246 |
det |
The,values |
R5620 |
T8246 |
T8249 |
nsubj |
values,indicate |
R5621 |
T8247 |
T8246 |
compound |
p,values |
R5622 |
T8248 |
T8246 |
punct |
-,values |
R5623 |
T8250 |
T8251 |
det |
the,significance |
R5624 |
T8251 |
T8249 |
dobj |
significance,indicate |
R5625 |
T8252 |
T8251 |
prep |
of,significance |
R5626 |
T8253 |
T8254 |
det |
the,difference |
R5627 |
T8254 |
T8252 |
pobj |
difference,of |
R5628 |
T8255 |
T8249 |
advcl |
relative,indicate |
R5629 |
T8256 |
T8255 |
prep |
to,relative |
R5630 |
T8257 |
T8258 |
compound |
XpdTTD,TTD |
R5631 |
T8258 |
T8256 |
pobj |
TTD,to |
R5632 |
T8259 |
T8258 |
punct |
/,TTD |
R5633 |
T8260 |
T8249 |
punct |
.,indicate |
R5634 |
T8262 |
T8263 |
compound |
Error,bars |
R5635 |
T8263 |
T8264 |
nsubj |
bars,indicate |
R5636 |
T8265 |
T8264 |
dobj |
SEM,indicate |
R5637 |
T8266 |
T8264 |
punct |
.,indicate |
R5638 |
T8268 |
T8269 |
punct |
(,D |
R5639 |
T8269 |
T8270 |
meta |
D,curves |
R5640 |
T8271 |
T8269 |
punct |
),D |
R5641 |
T8272 |
T8273 |
compound |
Body,weight |
R5642 |
T8273 |
T8270 |
compound |
weight,curves |
R5643 |
T8274 |
T8270 |
prep |
as,curves |
R5644 |
T8275 |
T8276 |
det |
a,function |
R5645 |
T8276 |
T8274 |
pobj |
function,as |
R5646 |
T8277 |
T8276 |
prep |
of,function |
R5647 |
T8278 |
T8277 |
pobj |
time,of |
R5648 |
T8279 |
T8270 |
punct |
.,curves |
R5649 |
T8282 |
T8283 |
mark |
that,rescued |
R5650 |
T8283 |
T8281 |
ccomp |
rescued,Note |
R5651 |
T8284 |
T8285 |
det |
the,cachexia |
R5652 |
T8285 |
T8283 |
nsubjpass |
cachexia,rescued |
R5653 |
T8286 |
T8287 |
npadvmod |
age,dependent |
R5654 |
T8287 |
T8285 |
amod |
dependent,cachexia |
R5655 |
T8288 |
T8287 |
punct |
-,dependent |
R5656 |
T8289 |
T8285 |
acl |
observed,cachexia |
R5657 |
T8290 |
T8289 |
prep |
in,observed |
R5658 |
T8291 |
T8292 |
compound |
XpdTTD,TTD |
R5659 |
T8292 |
T8294 |
compound |
TTD,mice |
R5660 |
T8293 |
T8292 |
punct |
/,TTD |
R5661 |
T8294 |
T8290 |
pobj |
mice,in |
R5662 |
T8295 |
T8283 |
auxpass |
was,rescued |
R5663 |
T8296 |
T8283 |
prep |
in,rescued |
R5664 |
T8297 |
T8298 |
preconj |
both,male |
R5665 |
T8298 |
T8299 |
nmod |
male,mice |
R5666 |
T8299 |
T8296 |
pobj |
mice,in |
R5667 |
T8300 |
T8298 |
cc |
and,male |
R5668 |
T8301 |
T8298 |
conj |
female,male |
R5669 |
T8302 |
T8303 |
compound |
XpdTTD , †XPCS |
R5670 |
T8303 |
T8299 |
compound |
†XPCS,mice |
R5671 |
T8304 |
T8303 |
punct |
/, †XPCS |
R5672 |
T8305 |
T8281 |
punct |
.,Note |
R5673 |
T8307 |
T8308 |
amod |
Significant,differences |
R5674 |
T8308 |
T8309 |
nsubjpass |
differences,observed |
R5675 |
T8310 |
T8308 |
prep |
between,differences |
R5676 |
T8311 |
T8310 |
pobj |
wt,between |
R5677 |
T8312 |
T8311 |
cc |
and,wt |
R5678 |
T8313 |
T8314 |
compound |
XpdTTD,TTD |
R5679 |
T8314 |
T8311 |
conj |
TTD,wt |
R5680 |
T8315 |
T8314 |
punct |
/,TTD |
R5681 |
T8316 |
T8310 |
cc |
but,between |
R5682 |
T8317 |
T8316 |
neg |
not,but |
R5683 |
T8318 |
T8310 |
conj |
between,between |
R5684 |
T8319 |
T8320 |
nmod |
wt,mice |
R5685 |
T8320 |
T8318 |
pobj |
mice,between |
R5686 |
T8321 |
T8319 |
cc |
and,wt |
R5687 |
T8322 |
T8323 |
compound |
XpdTTD,†XPCS |
R5688 |
T8323 |
T8319 |
conj |
†XPCS,wt |
R5689 |
T8324 |
T8323 |
punct |
/,†XPCS |
R5690 |
T8325 |
T8309 |
auxpass |
were,observed |
R5691 |
T8326 |
T8309 |
prep |
at,observed |
R5692 |
T8327 |
T8328 |
nummod |
9,mo |
R5693 |
T8328 |
T8326 |
pobj |
mo,at |
R5694 |
T8329 |
T8327 |
cc |
and,9 |
R5695 |
T8330 |
T8327 |
conj |
18,9 |
R5696 |
T8331 |
T8328 |
prep |
of,mo |
R5697 |
T8332 |
T8331 |
pobj |
age,of |
R5698 |
T8333 |
T8334 |
mark |
as,indicated |
R5699 |
T8334 |
T8309 |
advcl |
indicated,observed |
R5700 |
T8335 |
T8334 |
agent |
by,indicated |
R5701 |
T8336 |
T8335 |
pobj |
asterisks,by |
R5702 |
T8337 |
T8309 |
punct |
.,observed |
R5703 |
T8339 |
T8340 |
compound |
Error,bars |
R5704 |
T8340 |
T8341 |
nsubj |
bars,indicate |
R5705 |
T8342 |
T8341 |
dobj |
SEM,indicate |
R5706 |
T8343 |
T8341 |
punct |
.,indicate |
R6322 |
T9241 |
T9242 |
amod |
Pleiotropic,Effects |
R6323 |
T9243 |
T9242 |
nmod |
Xpd,Effects |
R6324 |
T9244 |
T9242 |
amod |
Biallelic,Effects |
R6325 |
T9245 |
T9242 |
prep |
in,Effects |
R6326 |
T9246 |
T9245 |
pobj |
Mice,in |
R6327 |
T9247 |
T9246 |
cc |
and,Mice |
R6328 |
T9248 |
T9246 |
conj |
Cells,Mice |
R1910 |
T2792 |
T2793 |
aux |
To,determine |
R1911 |
T2793 |
T2794 |
advcl |
determine,generated |
R1912 |
T2795 |
T2796 |
mark |
whether,was |
R1913 |
T2796 |
T2793 |
ccomp |
was,determine |
R1914 |
T2797 |
T2798 |
det |
the,allele |
R1915 |
T2798 |
T2796 |
nsubj |
allele,was |
R1916 |
T2799 |
T2798 |
amod |
homozygous,allele |
R1917 |
T2800 |
T2798 |
amod |
lethal,allele |
R1918 |
T2801 |
T2798 |
compound |
Xpd†XPCS,allele |
R1919 |
T2802 |
T2796 |
acomp |
unique,was |
R1920 |
T2803 |
T2802 |
prep |
in,unique |
R1921 |
T2804 |
T2805 |
poss |
its,ability |
R1922 |
T2805 |
T2803 |
pobj |
ability,in |