Id |
Subject |
Object |
Predicate |
Lexical cue |
T1973 |
0-8 |
VBD |
denotes |
combined |
T1992 |
9-11 |
DT |
denotes |
an |
T1993 |
21-27 |
NN |
denotes |
allele |
T1994 |
12-20 |
NN |
denotes |
Xpd†XPCS |
T1995 |
28-32 |
IN |
denotes |
with |
T1996 |
33-34 |
DT |
denotes |
a |
T1997 |
49-55 |
NN |
denotes |
allele |
T1998 |
35-41 |
JJ |
denotes |
viable |
T1999 |
42-48 |
NN |
denotes |
XpdTTD |
T2000 |
56-58 |
IN |
denotes |
by |
T2001 |
59-67 |
VBG |
denotes |
crossing |
T2002 |
68-71 |
DT |
denotes |
the |
T2003 |
99-106 |
NNS |
denotes |
animals |
T2004 |
72-85 |
VBG |
denotes |
corresponding |
T2005 |
86-98 |
JJ |
denotes |
heterozygous |
T2006 |
106-107 |
. |
denotes |
. |
T2007 |
107-278 |
sentence |
denotes |
Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies. |
T2008 |
108-115 |
JJ |
denotes |
Similar |
T2009 |
235-239 |
VBN |
denotes |
born |
T2010 |
116-118 |
IN |
denotes |
to |
T2011 |
119-129 |
JJ |
denotes |
hemizygous |
T2012 |
134-138 |
NNS |
denotes |
mice |
T2013 |
130-133 |
NN |
denotes |
TTD |
T2014 |
139-147 |
VBG |
denotes |
carrying |
T2015 |
148-151 |
CD |
denotes |
one |
T2016 |
170-176 |
NN |
denotes |
allele |
T2017 |
152-156 |
JJ |
denotes |
true |
T2018 |
157-160 |
NN |
denotes |
Xpd |
T2019 |
161-169 |
NN |
denotes |
knockout |
T2020 |
177-178 |
-LRB- |
denotes |
( |
T2021 |
185-187 |
NN |
denotes |
KO |
T2022 |
178-184 |
NN |
denotes |
XpdTTD |
T2023 |
184-185 |
HYPH |
denotes |
/ |
T2024 |
187-188 |
-RRB- |
denotes |
) |
T2025 |
188-190 |
, |
denotes |
, |
T2026 |
190-198 |
NN |
denotes |
compound |
T2027 |
225-229 |
NNS |
denotes |
mice |
T2028 |
199-211 |
JJ |
denotes |
heterozygous |
T2029 |
212-218 |
NN |
denotes |
XpdTTD |
T2030 |
219-224 |
NN |
denotes |
†XPCS |
T2031 |
218-219 |
HYPH |
denotes |
/ |
T2032 |
230-234 |
VBD |
denotes |
were |
T2033 |
240-242 |
IN |
denotes |
at |
T2034 |
243-246 |
DT |
denotes |
the |
T2035 |
266-277 |
NNS |
denotes |
frequencies |
T2036 |
247-255 |
VBN |
denotes |
expected |
T2037 |
256-265 |
JJ |
denotes |
Mendelian |
T2038 |
277-278 |
. |
denotes |
. |
T2039 |
278-474 |
sentence |
denotes |
Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E). |
T2040 |
279-289 |
NN |
denotes |
Expression |
T2041 |
324-331 |
VBN |
denotes |
reduced |
T2042 |
290-294 |
IN |
denotes |
from |
T2043 |
295-298 |
DT |
denotes |
the |
T2044 |
308-314 |
NN |
denotes |
allele |
T2045 |
299-307 |
NN |
denotes |
Xpd†XPCS |
T2046 |
315-318 |
VBD |
denotes |
was |
T2047 |
319-323 |
RB |
denotes |
also |
T2048 |
332-334 |
IN |
denotes |
in |
T2049 |
335-338 |
DT |
denotes |
the |
T2050 |
339-345 |
NN |
denotes |
testis |
T2051 |
346-348 |
IN |
denotes |
of |
T2052 |
349-357 |
NN |
denotes |
compound |
T2053 |
371-378 |
NNS |
denotes |
animals |
T2054 |
358-370 |
JJ |
denotes |
heterozygous |
T2055 |
378-380 |
, |
denotes |
, |
T2056 |
380-387 |
IN |
denotes |
whereas |
T2057 |
426-435 |
VBN |
denotes |
increased |
T2058 |
388-398 |
NN |
denotes |
expression |
T2059 |
399-403 |
IN |
denotes |
from |
T2060 |
404-407 |
DT |
denotes |
the |
T2061 |
415-421 |
NN |
denotes |
allele |
T2062 |
408-414 |
NN |
denotes |
XpdTTD |
T2063 |
422-425 |
VBD |
denotes |
was |
T2064 |
436-444 |
JJ |
denotes |
relative |
T2065 |
445-447 |
IN |
denotes |
to |
T2066 |
448-450 |
NN |
denotes |
wt |
T2067 |
451-453 |
IN |
denotes |
by |
T2068 |
454-455 |
SYM |
denotes |
~ |
T2069 |
455-461 |
RB |
denotes |
5-fold |
T2070 |
462-463 |
-LRB- |
denotes |
( |
T2071 |
470-472 |
NN |
denotes |
1E |
T2072 |
463-469 |
NN |
denotes |
Figure |
T2073 |
472-473 |
-RRB- |
denotes |
) |
T2074 |
473-474 |
. |
denotes |
. |
T2075 |
474-727 |
sentence |
denotes |
Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles. |
T2076 |
475-482 |
IN |
denotes |
Because |
T2077 |
640-644 |
VBD |
denotes |
were |
T2078 |
483-485 |
IN |
denotes |
of |
T2079 |
486-487 |
DT |
denotes |
a |
T2080 |
488-492 |
NN |
denotes |
lack |
T2081 |
493-495 |
IN |
denotes |
of |
T2082 |
496-505 |
JJ |
denotes |
available |
T2083 |
506-516 |
NNS |
denotes |
antibodies |
T2084 |
517-520 |
CC |
denotes |
and |
T2085 |
521-524 |
DT |
denotes |
the |
T2086 |
525-534 |
NN |
denotes |
inability |
T2087 |
535-537 |
TO |
denotes |
to |
T2088 |
538-549 |
VB |
denotes |
distinguish |
T2089 |
550-557 |
IN |
denotes |
amongst |
T2090 |
558-565 |
JJ |
denotes |
various |
T2091 |
573-578 |
NNS |
denotes |
forms |
T2092 |
566-572 |
JJ |
denotes |
mutant |
T2093 |
579-581 |
IN |
denotes |
of |
T2094 |
582-585 |
NN |
denotes |
XPD |
T2095 |
586-595 |
VBG |
denotes |
differing |
T2096 |
596-600 |
RB |
denotes |
only |
T2097 |
601-603 |
IN |
denotes |
by |
T2098 |
604-610 |
JJ |
denotes |
single |
T2099 |
622-635 |
NNS |
denotes |
substitutions |
T2100 |
611-616 |
NN |
denotes |
amino |
T2101 |
617-621 |
NN |
denotes |
acid |
T2102 |
635-637 |
, |
denotes |
, |
T2103 |
637-639 |
PRP |
denotes |
we |
T2104 |
645-651 |
JJ |
denotes |
unable |
T2105 |
652-654 |
TO |
denotes |
to |
T2106 |
655-664 |
VB |
denotes |
ascertain |
T2107 |
665-668 |
DT |
denotes |
the |
T2108 |
678-684 |
NN |
denotes |
amount |
T2109 |
669-677 |
JJ |
denotes |
relative |
T2110 |
685-687 |
IN |
denotes |
of |
T2111 |
688-691 |
NN |
denotes |
XPD |
T2112 |
692-699 |
NN |
denotes |
protein |
T2113 |
700-704 |
IN |
denotes |
from |
T2114 |
705-708 |
DT |
denotes |
the |
T2115 |
719-726 |
NNS |
denotes |
alleles |
T2116 |
709-718 |
JJ |
denotes |
different |
T2117 |
726-727 |
. |
denotes |
. |
T2118 |
727-1034 |
sentence |
denotes |
Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C). |
T2119 |
728-735 |
IN |
denotes |
Despite |
T2120 |
809-820 |
VBD |
denotes |
ameliorated |
T2121 |
736-743 |
VBN |
denotes |
reduced |
T2122 |
744-750 |
NNS |
denotes |
levels |
T2123 |
751-753 |
IN |
denotes |
of |
T2124 |
754-758 |
NN |
denotes |
mRNA |
T2125 |
759-769 |
NN |
denotes |
expression |
T2126 |
769-771 |
, |
denotes |
, |
T2127 |
771-774 |
DT |
denotes |
the |
T2128 |
802-808 |
NN |
denotes |
allele |
T2129 |
775-785 |
JJ |
denotes |
homozygous |
T2130 |
786-792 |
JJ |
denotes |
lethal |
T2131 |
793-801 |
NN |
denotes |
Xpd†XPCS |
T2132 |
821-829 |
JJ |
denotes |
multiple |
T2133 |
856-864 |
NNS |
denotes |
symptoms |
T2134 |
830-836 |
NN |
denotes |
XpdTTD |
T2135 |
837-847 |
JJ |
denotes |
associated |
T2136 |
836-837 |
HYPH |
denotes |
- |
T2137 |
848-855 |
NN |
denotes |
disease |
T2138 |
865-867 |
IN |
denotes |
in |
T2139 |
868-876 |
JJ |
denotes |
compound |
T2140 |
903-910 |
NNS |
denotes |
animals |
T2141 |
877-889 |
JJ |
denotes |
heterozygous |
T2142 |
890-896 |
NN |
denotes |
XpdTTD |
T2143 |
897-902 |
NN |
denotes |
†XPCS |
T2144 |
896-897 |
HYPH |
denotes |
/ |
T2145 |
911-920 |
VBG |
denotes |
including |
T2146 |
921-924 |
DT |
denotes |
the |
T2147 |
942-946 |
NN |
denotes |
hair |
T2148 |
925-933 |
NN |
denotes |
hallmark |
T2149 |
934-941 |
JJ |
denotes |
brittle |
T2150 |
947-950 |
CC |
denotes |
and |
T2151 |
951-960 |
JJ |
denotes |
cutaneous |
T2152 |
961-969 |
NNS |
denotes |
features |
T2153 |
970-975 |
RB |
denotes |
fully |
T2154 |
976-985 |
JJ |
denotes |
penetrant |
T2155 |
986-988 |
IN |
denotes |
in |
T2156 |
989-993 |
AFX |
denotes |
homo |
T2157 |
999-1009 |
JJ |
denotes |
hemizygous |
T2158 |
993-994 |
HYPH |
denotes |
- |
T2159 |
995-998 |
CC |
denotes |
and |
T2160 |
1014-1018 |
NNS |
denotes |
mice |
T2161 |
1010-1013 |
NN |
denotes |
TTD |
T2162 |
1019-1020 |
-LRB- |
denotes |
( |
T2163 |
1027-1029 |
NN |
denotes |
2A |
T2164 |
1020-1026 |
NN |
denotes |
Figure |
T2165 |
1029-1030 |
SYM |
denotes |
– |
T2166 |
1030-1032 |
NN |
denotes |
2C |
T2167 |
1032-1033 |
-RRB- |
denotes |
) |
T2168 |
1033-1034 |
. |
denotes |
. |
T2169 |
1034-1358 |
sentence |
denotes |
In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A). |
T2170 |
1035-1037 |
IN |
denotes |
In |
T2171 |
1259-1268 |
VBD |
denotes |
displayed |
T2172 |
1038-1044 |
JJ |
denotes |
marked |
T2173 |
1045-1053 |
NN |
denotes |
contrast |
T2174 |
1054-1056 |
IN |
denotes |
to |
T2175 |
1057-1063 |
NN |
denotes |
XpdTTD |
T2176 |
1064-1067 |
NN |
denotes |
TTD |
T2177 |
1063-1064 |
HYPH |
denotes |
/ |
T2178 |
1084-1088 |
NNS |
denotes |
mice |
T2179 |
1068-1069 |
-LRB- |
denotes |
( |
T2180 |
1069-1072 |
CC |
denotes |
and |
T2181 |
1073-1079 |
NN |
denotes |
XpdTTD |
T2182 |
1080-1082 |
NN |
denotes |
KO |
T2183 |
1079-1080 |
HYPH |
denotes |
/ |
T2184 |
1082-1083 |
-RRB- |
denotes |
) |
T2185 |
1088-1090 |
, |
denotes |
, |
T2186 |
1090-1095 |
WDT |
denotes |
which |
T2187 |
1096-1103 |
VBP |
denotes |
display |
T2188 |
1104-1112 |
JJ |
denotes |
complete |
T2189 |
1118-1122 |
NN |
denotes |
loss |
T2190 |
1113-1117 |
NN |
denotes |
hair |
T2191 |
1123-1125 |
IN |
denotes |
in |
T2192 |
1126-1129 |
DT |
denotes |
the |
T2193 |
1141-1146 |
NN |
denotes |
cycle |
T2194 |
1130-1135 |
JJ |
denotes |
first |
T2195 |
1136-1140 |
NN |
denotes |
hair |
T2196 |
1147-1150 |
CC |
denotes |
and |
T2197 |
1151-1158 |
JJ |
denotes |
partial |
T2198 |
1164-1168 |
NN |
denotes |
loss |
T2199 |
1159-1163 |
NN |
denotes |
hair |
T2200 |
1169-1171 |
IN |
denotes |
in |
T2201 |
1172-1182 |
JJ |
denotes |
subsequent |
T2202 |
1183-1189 |
NNS |
denotes |
cycles |
T2203 |
1190-1200 |
IN |
denotes |
throughout |
T2204 |
1201-1206 |
PRP$ |
denotes |
their |
T2205 |
1207-1212 |
NNS |
denotes |
lives |
T2206 |
1213-1214 |
-LRB- |
denotes |
[ |
T2207 |
1214-1216 |
CD |
denotes |
21 |
T2208 |
1216-1217 |
-RRB- |
denotes |
] |
T2209 |
1217-1219 |
, |
denotes |
, |
T2210 |
1219-1227 |
NN |
denotes |
compound |
T2211 |
1254-1258 |
NNS |
denotes |
mice |
T2212 |
1228-1240 |
JJ |
denotes |
heterozygous |
T2213 |
1241-1253 |
NN |
denotes |
XpdTTD/†XPCS |
T2214 |
1269-1273 |
DT |
denotes |
some |
T2215 |
1279-1283 |
NN |
denotes |
loss |
T2216 |
1274-1278 |
NN |
denotes |
hair |
T2217 |
1284-1288 |
RB |
denotes |
only |
T2218 |
1289-1295 |
IN |
denotes |
during |
T2219 |
1296-1299 |
DT |
denotes |
the |
T2220 |
1311-1316 |
NN |
denotes |
cycle |
T2221 |
1300-1305 |
JJ |
denotes |
first |
T2222 |
1306-1310 |
NN |
denotes |
hair |
T2223 |
1317-1320 |
CC |
denotes |
and |
T2224 |
1321-1325 |
RB |
denotes |
only |
T2225 |
1326-1333 |
RB |
denotes |
locally |
T2226 |
1334-1336 |
IN |
denotes |
at |
T2227 |
1337-1340 |
DT |
denotes |
the |
T2228 |
1341-1345 |
NN |
denotes |
back |
T2229 |
1346-1347 |
-LRB- |
denotes |
( |
T2230 |
1354-1356 |
NN |
denotes |
2A |
T2231 |
1347-1353 |
NN |
denotes |
Figure |
T2232 |
1356-1357 |
-RRB- |
denotes |
) |
T2233 |
1357-1358 |
. |
denotes |
. |
T2234 |
1358-1552 |
sentence |
denotes |
Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data). |
T2235 |
1359-1367 |
NN |
denotes |
Scanning |
T2236 |
1377-1387 |
NN |
denotes |
microscope |
T2237 |
1368-1376 |
NN |
denotes |
electron |
T2238 |
1388-1396 |
NN |
denotes |
analysis |
T2239 |
1418-1426 |
VBD |
denotes |
revealed |
T2240 |
1397-1399 |
IN |
denotes |
of |
T2241 |
1400-1406 |
NN |
denotes |
XpdTTD |
T2242 |
1407-1412 |
NN |
denotes |
†XPCS |
T2243 |
1406-1407 |
HYPH |
denotes |
/ |
T2244 |
1413-1417 |
NN |
denotes |
hair |
T2245 |
1427-1429 |
DT |
denotes |
an |
T2246 |
1444-1454 |
NN |
denotes |
appearance |
T2247 |
1430-1436 |
RB |
denotes |
almost |
T2248 |
1437-1443 |
JJ |
denotes |
normal |
T2249 |
1454-1456 |
, |
denotes |
, |
T2250 |
1456-1460 |
IN |
denotes |
with |
T2251 |
1461-1464 |
NN |
denotes |
TTD |
T2252 |
1465-1469 |
JJ |
denotes |
like |
T2253 |
1464-1465 |
HYPH |
denotes |
- |
T2254 |
1470-1478 |
NNS |
denotes |
features |
T2255 |
1479-1483 |
JJ |
denotes |
such |
T2256 |
1484-1486 |
IN |
denotes |
as |
T2257 |
1487-1493 |
JJ |
denotes |
broken |
T2258 |
1494-1499 |
NNS |
denotes |
hairs |
T2259 |
1500-1505 |
VBN |
denotes |
found |
T2260 |
1506-1510 |
RB |
denotes |
only |
T2261 |
1511-1513 |
IN |
denotes |
at |
T2262 |
1514-1518 |
RB |
denotes |
very |
T2263 |
1519-1522 |
JJ |
denotes |
low |
T2264 |
1523-1532 |
NN |
denotes |
frequency |
T2265 |
1533-1534 |
-LRB- |
denotes |
( |
T2266 |
1546-1550 |
NNS |
denotes |
data |
T2267 |
1534-1545 |
JJ |
denotes |
unpublished |
T2268 |
1550-1551 |
-RRB- |
denotes |
) |
T2269 |
1551-1552 |
. |
denotes |
. |
T2271 |
1553-1558 |
NN |
denotes |
Amino |
T2272 |
1559-1563 |
NN |
denotes |
acid |
T2273 |
1564-1572 |
NN |
denotes |
analysis |
T2274 |
1573-1582 |
VBD |
denotes |
confirmed |
T2275 |
1583-1587 |
IN |
denotes |
that |
T2276 |
1641-1645 |
VBD |
denotes |
were |
T2277 |
1588-1596 |
NN |
denotes |
cysteine |
T2278 |
1597-1603 |
NNS |
denotes |
levels |
T2279 |
1604-1606 |
IN |
denotes |
in |
T2280 |
1607-1610 |
DT |
denotes |
the |
T2281 |
1611-1615 |
NN |
denotes |
hair |
T2282 |
1616-1618 |
IN |
denotes |
of |
T2283 |
1619-1622 |
DT |
denotes |
the |
T2284 |
1636-1640 |
NNS |
denotes |
mice |
T2285 |
1623-1629 |
NN |
denotes |
XpdTTD |
T2286 |
1630-1635 |
NN |
denotes |
†XPCS |
T2287 |
1629-1630 |
HYPH |
denotes |
/ |
T2288 |
1646-1659 |
RB |
denotes |
significantly |
R1261 |
T1992 |
T1993 |
det |
an,allele |
R1262 |
T1993 |
T1973 |
dobj |
allele,combined |
R1263 |
T1994 |
T1993 |
compound |
Xpd†XPCS,allele |
R1264 |
T1995 |
T1993 |
prep |
with,allele |
R1265 |
T1996 |
T1997 |
det |
a,allele |
R1266 |
T1997 |
T1995 |
pobj |
allele,with |
R1267 |
T1998 |
T1997 |
amod |
viable,allele |
R1268 |
T1999 |
T1997 |
compound |
XpdTTD,allele |
R1269 |
T2000 |
T1973 |
prep |
by,combined |
R1270 |
T2001 |
T2000 |
pcomp |
crossing,by |
R1271 |
T2002 |
T2003 |
det |
the,animals |
R1272 |
T2003 |
T2001 |
dobj |
animals,crossing |
R1273 |
T2004 |
T2003 |
amod |
corresponding,animals |
R1274 |
T2005 |
T2003 |
amod |
heterozygous,animals |
R1275 |
T2006 |
T1973 |
punct |
.,combined |
R1276 |
T2008 |
T2009 |
advcl |
Similar,born |
R1277 |
T2010 |
T2008 |
prep |
to,Similar |
R1278 |
T2011 |
T2012 |
amod |
hemizygous,mice |
R1279 |
T2012 |
T2010 |
pobj |
mice,to |
R1280 |
T2013 |
T2012 |
compound |
TTD,mice |
R1281 |
T2014 |
T2012 |
acl |
carrying,mice |
R1282 |
T2015 |
T2016 |
nummod |
one,allele |
R1283 |
T2016 |
T2014 |
dobj |
allele,carrying |
R1284 |
T2017 |
T2016 |
amod |
true,allele |
R1285 |
T2018 |
T2019 |
compound |
Xpd,knockout |
R1286 |
T2019 |
T2016 |
compound |
knockout,allele |
R1287 |
T2020 |
T2021 |
punct |
(,KO |
R1288 |
T2021 |
T2016 |
parataxis |
KO,allele |
R1289 |
T2022 |
T2021 |
compound |
XpdTTD,KO |
R1290 |
T2023 |
T2021 |
punct |
/,KO |
R1291 |
T2024 |
T2021 |
punct |
),KO |
R1292 |
T2025 |
T2009 |
punct |
", ",born |
R1293 |
T2026 |
T2027 |
nmod |
compound,mice |
R1294 |
T2027 |
T2009 |
nsubjpass |
mice,born |
R1295 |
T2028 |
T2027 |
amod |
heterozygous,mice |
R1296 |
T2029 |
T2030 |
compound |
XpdTTD,†XPCS |
R1297 |
T2030 |
T2027 |
compound |
†XPCS,mice |
R1298 |
T2031 |
T2030 |
punct |
/,†XPCS |
R1299 |
T2032 |
T2009 |
auxpass |
were,born |
R1300 |
T2033 |
T2009 |
prep |
at,born |
R1301 |
T2034 |
T2035 |
det |
the,frequencies |
R1302 |
T2035 |
T2033 |
pobj |
frequencies,at |
R1303 |
T2036 |
T2035 |
amod |
expected,frequencies |
R1304 |
T2037 |
T2035 |
amod |
Mendelian,frequencies |
R1305 |
T2038 |
T2009 |
punct |
.,born |
R1306 |
T2040 |
T2041 |
nsubjpass |
Expression,reduced |
R1307 |
T2042 |
T2040 |
prep |
from,Expression |
R1308 |
T2043 |
T2044 |
det |
the,allele |
R1309 |
T2044 |
T2042 |
pobj |
allele,from |
R1310 |
T2045 |
T2044 |
compound |
Xpd†XPCS,allele |
R1311 |
T2046 |
T2041 |
auxpass |
was,reduced |
R1312 |
T2047 |
T2041 |
advmod |
also,reduced |
R1313 |
T2048 |
T2041 |
prep |
in,reduced |
R1314 |
T2049 |
T2050 |
det |
the,testis |
R1315 |
T2050 |
T2048 |
pobj |
testis,in |
R1316 |
T2051 |
T2050 |
prep |
of,testis |
R1317 |
T2052 |
T2053 |
nmod |
compound,animals |
R1318 |
T2053 |
T2051 |
pobj |
animals,of |
R1319 |
T2054 |
T2053 |
amod |
heterozygous,animals |
R1320 |
T2055 |
T2041 |
punct |
", ",reduced |
R1321 |
T2056 |
T2057 |
mark |
whereas,increased |
R1322 |
T2057 |
T2041 |
advcl |
increased,reduced |
R1323 |
T2058 |
T2057 |
nsubjpass |
expression,increased |
R1324 |
T2059 |
T2058 |
prep |
from,expression |
R1325 |
T2060 |
T2061 |
det |
the,allele |
R1326 |
T2061 |
T2059 |
pobj |
allele,from |
R1327 |
T2062 |
T2061 |
compound |
XpdTTD,allele |
R1328 |
T2063 |
T2057 |
auxpass |
was,increased |
R1329 |
T2064 |
T2057 |
advcl |
relative,increased |
R1330 |
T2065 |
T2064 |
prep |
to,relative |
R1331 |
T2066 |
T2065 |
pobj |
wt,to |
R1332 |
T2067 |
T2057 |
prep |
by,increased |
R1333 |
T2068 |
T2069 |
punct |
~,5-fold |
R1334 |
T2069 |
T2067 |
pobj |
5-fold,by |
R1335 |
T2070 |
T2071 |
punct |
(,1E |
R1336 |
T2071 |
T2057 |
parataxis |
1E,increased |
R1337 |
T2072 |
T2071 |
compound |
Figure,1E |
R1338 |
T2073 |
T2071 |
punct |
),1E |
R1339 |
T2074 |
T2041 |
punct |
.,reduced |
R1340 |
T2076 |
T2077 |
prep |
Because,were |
R1341 |
T2078 |
T2076 |
pcomp |
of,Because |
R1342 |
T2079 |
T2080 |
det |
a,lack |
R1343 |
T2080 |
T2076 |
pobj |
lack,Because |
R1344 |
T2081 |
T2080 |
prep |
of,lack |
R1345 |
T2082 |
T2083 |
amod |
available,antibodies |
R1346 |
T2083 |
T2081 |
pobj |
antibodies,of |
R1347 |
T2084 |
T2083 |
cc |
and,antibodies |
R1348 |
T2085 |
T2086 |
det |
the,inability |
R1349 |
T2086 |
T2083 |
conj |
inability,antibodies |
R1350 |
T2087 |
T2088 |
aux |
to,distinguish |
R1351 |
T2088 |
T2086 |
acl |
distinguish,inability |
R1352 |
T2089 |
T2088 |
prep |
amongst,distinguish |
R1353 |
T2090 |
T2091 |
amod |
various,forms |
R1354 |
T2091 |
T2089 |
pobj |
forms,amongst |
R1355 |
T2092 |
T2091 |
amod |
mutant,forms |
R1356 |
T2093 |
T2091 |
prep |
of,forms |
R1357 |
T2094 |
T2093 |
pobj |
XPD,of |
R1358 |
T2095 |
T2091 |
acl |
differing,forms |
R1359 |
T2096 |
T2095 |
advmod |
only,differing |
R1360 |
T2097 |
T2095 |
prep |
by,differing |
R1361 |
T2098 |
T2099 |
amod |
single,substitutions |
R1362 |
T2099 |
T2097 |
pobj |
substitutions,by |
R1363 |
T2100 |
T2101 |
compound |
amino,acid |
R1364 |
T2101 |
T2099 |
compound |
acid,substitutions |
R1365 |
T2102 |
T2077 |
punct |
", ",were |
R1366 |
T2103 |
T2077 |
nsubj |
we,were |
R1367 |
T2104 |
T2077 |
acomp |
unable,were |
R1368 |
T2105 |
T2106 |
aux |
to,ascertain |
R1369 |
T2106 |
T2104 |
xcomp |
ascertain,unable |
R1370 |
T2107 |
T2108 |
det |
the,amount |
R1371 |
T2108 |
T2106 |
dobj |
amount,ascertain |
R1372 |
T2109 |
T2108 |
amod |
relative,amount |
R1373 |
T2110 |
T2108 |
prep |
of,amount |
R1374 |
T2111 |
T2112 |
compound |
XPD,protein |
R1375 |
T2112 |
T2110 |
pobj |
protein,of |
R1376 |
T2113 |
T2112 |
prep |
from,protein |
R1377 |
T2114 |
T2115 |
det |
the,alleles |
R1378 |
T2115 |
T2113 |
pobj |
alleles,from |
R1379 |
T2116 |
T2115 |
amod |
different,alleles |
R1380 |
T2117 |
T2077 |
punct |
.,were |
R1381 |
T2119 |
T2120 |
prep |
Despite,ameliorated |
R1382 |
T2121 |
T2122 |
amod |
reduced,levels |
R1383 |
T2122 |
T2119 |
pobj |
levels,Despite |
R1384 |
T2123 |
T2122 |
prep |
of,levels |
R1385 |
T2124 |
T2125 |
compound |
mRNA,expression |
R1386 |
T2125 |
T2123 |
pobj |
expression,of |
R1387 |
T2126 |
T2120 |
punct |
", ",ameliorated |
R1388 |
T2127 |
T2128 |
det |
the,allele |
R1389 |
T2128 |
T2120 |
nsubj |
allele,ameliorated |
R1390 |
T2129 |
T2128 |
amod |
homozygous,allele |
R1391 |
T2130 |
T2128 |
amod |
lethal,allele |
R1392 |
T2131 |
T2128 |
compound |
Xpd†XPCS,allele |
R1393 |
T2132 |
T2133 |
amod |
multiple,symptoms |
R1394 |
T2133 |
T2120 |
dobj |
symptoms,ameliorated |
R1395 |
T2134 |
T2135 |
npadvmod |
XpdTTD,associated |
R1396 |
T2135 |
T2133 |
amod |
associated,symptoms |
R1397 |
T2136 |
T2135 |
punct |
-,associated |
R1398 |
T2137 |
T2133 |
compound |
disease,symptoms |
R1399 |
T2138 |
T2120 |
prep |
in,ameliorated |
R1400 |
T2139 |
T2140 |
amod |
compound,animals |
R1401 |
T2140 |
T2138 |
pobj |
animals,in |
R1402 |
T2141 |
T2140 |
amod |
heterozygous,animals |
R1403 |
T2142 |
T2143 |
compound |
XpdTTD,†XPCS |
R1404 |
T2143 |
T2140 |
compound |
†XPCS,animals |
R1405 |
T2144 |
T2143 |
punct |
/,†XPCS |
R1406 |
T2145 |
T2120 |
prep |
including,ameliorated |
R1407 |
T2146 |
T2147 |
det |
the,hair |
R1408 |
T2147 |
T2145 |
pobj |
hair,including |
R1409 |
T2148 |
T2147 |
nmod |
hallmark,hair |
R1410 |
T2149 |
T2147 |
amod |
brittle,hair |
R1411 |
T2150 |
T2147 |
cc |
and,hair |
R1412 |
T2151 |
T2152 |
amod |
cutaneous,features |
R1413 |
T2152 |
T2147 |
conj |
features,hair |
R1414 |
T2153 |
T2154 |
advmod |
fully,penetrant |
R1415 |
T2154 |
T2147 |
amod |
penetrant,hair |
R1416 |
T2155 |
T2154 |
prep |
in,penetrant |
R1417 |
T2156 |
T2157 |
advmod |
homo,hemizygous |
R1418 |
T2157 |
T2160 |
amod |
hemizygous,mice |
R1419 |
T2158 |
T2157 |
punct |
-,hemizygous |
R1420 |
T2159 |
T2157 |
cc |
and,hemizygous |
R1421 |
T2160 |
T2155 |
pobj |
mice,in |
R1422 |
T2161 |
T2160 |
compound |
TTD,mice |
R1423 |
T2162 |
T2163 |
punct |
(,2A |
R1424 |
T2163 |
T2120 |
parataxis |
2A,ameliorated |
R1425 |
T2164 |
T2163 |
compound |
Figure,2A |
R1426 |
T2165 |
T2166 |
punct |
–,2C |
R1427 |
T2166 |
T2163 |
prep |
2C,2A |
R1428 |
T2167 |
T2163 |
punct |
),2A |
R1429 |
T2168 |
T2120 |
punct |
.,ameliorated |
R1430 |
T2170 |
T2171 |
prep |
In,displayed |
R1431 |
T2172 |
T2173 |
amod |
marked,contrast |
R1432 |
T2173 |
T2170 |
pobj |
contrast,In |
R1433 |
T2174 |
T2173 |
prep |
to,contrast |
R1434 |
T2175 |
T2176 |
nmod |
XpdTTD,TTD |
R1435 |
T2176 |
T2178 |
nmod |
TTD,mice |
R1436 |
T2177 |
T2176 |
punct |
/,TTD |
R1437 |
T2178 |
T2174 |
pobj |
mice,to |
R1438 |
T2179 |
T2176 |
punct |
(,TTD |
R1439 |
T2180 |
T2176 |
cc |
and,TTD |
R1440 |
T2181 |
T2182 |
compound |
XpdTTD,KO |
R1441 |
T2182 |
T2176 |
conj |
KO,TTD |
R1442 |
T2183 |
T2182 |
punct |
/,KO |
R1443 |
T2184 |
T2178 |
punct |
),mice |
R1444 |
T2185 |
T2178 |
punct |
", ",mice |
R1445 |
T2186 |
T2187 |
dep |
which,display |
R1446 |
T2187 |
T2178 |
relcl |
display,mice |
R1447 |
T2188 |
T2189 |
amod |
complete,loss |
R1448 |
T2189 |
T2187 |
dobj |
loss,display |
R1449 |
T2190 |
T2189 |
compound |
hair,loss |
R1450 |
T2191 |
T2189 |
prep |
in,loss |
R1451 |
T2192 |
T2193 |
det |
the,cycle |
R1452 |
T2193 |
T2191 |
pobj |
cycle,in |
R1453 |
T2194 |
T2193 |
amod |
first,cycle |
R1454 |
T2195 |
T2193 |
compound |
hair,cycle |
R1455 |
T2196 |
T2189 |
cc |
and,loss |
R1456 |
T2197 |
T2198 |
amod |
partial,loss |
R1457 |
T2198 |
T2189 |
conj |
loss,loss |
R1458 |
T2199 |
T2198 |
compound |
hair,loss |
R1459 |
T2200 |
T2198 |
prep |
in,loss |
R1460 |
T2201 |
T2202 |
amod |
subsequent,cycles |
R1461 |
T2202 |
T2200 |
pobj |
cycles,in |
R1462 |
T2203 |
T2187 |
prep |
throughout,display |
R1463 |
T2204 |
T2205 |
poss |
their,lives |
R1464 |
T2205 |
T2203 |
pobj |
lives,throughout |
R1465 |
T2206 |
T2207 |
punct |
[,21 |
R1466 |
T2207 |
T2187 |
parataxis |
21,display |
R1467 |
T2208 |
T2207 |
punct |
],21 |
R1468 |
T2209 |
T2171 |
punct |
", ",displayed |
R1469 |
T2210 |
T2211 |
nmod |
compound,mice |
R1470 |
T2211 |
T2171 |
nsubj |
mice,displayed |
R1471 |
T2212 |
T2211 |
amod |
heterozygous,mice |
R1472 |
T2213 |
T2211 |
compound |
XpdTTD/†XPCS,mice |
R1473 |
T2214 |
T2215 |
det |
some,loss |
R1474 |
T2215 |
T2171 |
dobj |
loss,displayed |
R1475 |
T2216 |
T2215 |
compound |
hair,loss |
R1476 |
T2217 |
T2218 |
advmod |
only,during |
R1477 |
T2218 |
T2171 |
prep |
during,displayed |
R1478 |
T2219 |
T2220 |
det |
the,cycle |
R1479 |
T2220 |
T2218 |
pobj |
cycle,during |
R1480 |
T2221 |
T2220 |
amod |
first,cycle |
R1481 |
T2222 |
T2220 |
compound |
hair,cycle |
R1482 |
T2223 |
T2218 |
cc |
and,during |
R1483 |
T2224 |
T2225 |
advmod |
only,locally |
R1484 |
T2225 |
T2226 |
advmod |
locally,at |
R1485 |
T2226 |
T2218 |
conj |
at,during |
R1486 |
T2227 |
T2228 |
det |
the,back |
R1487 |
T2228 |
T2226 |
pobj |
back,at |
R1488 |
T2229 |
T2230 |
punct |
(,2A |
R1489 |
T2230 |
T2171 |
parataxis |
2A,displayed |
R1490 |
T2231 |
T2230 |
compound |
Figure,2A |
R1491 |
T2232 |
T2230 |
punct |
),2A |
R1492 |
T2233 |
T2171 |
punct |
.,displayed |
R1493 |
T2235 |
T2236 |
compound |
Scanning,microscope |
R1494 |
T2236 |
T2238 |
compound |
microscope,analysis |
R1495 |
T2237 |
T2236 |
compound |
electron,microscope |
R1496 |
T2238 |
T2239 |
nsubj |
analysis,revealed |
R1497 |
T2240 |
T2238 |
prep |
of,analysis |
R1498 |
T2241 |
T2242 |
compound |
XpdTTD,†XPCS |
R1499 |
T2242 |
T2244 |
compound |
†XPCS,hair |
R1500 |
T2243 |
T2242 |
punct |
/,†XPCS |
R1501 |
T2244 |
T2240 |
pobj |
hair,of |
R1502 |
T2245 |
T2246 |
det |
an,appearance |
R1503 |
T2246 |
T2239 |
dobj |
appearance,revealed |
R1504 |
T2247 |
T2248 |
advmod |
almost,normal |
R1505 |
T2248 |
T2246 |
amod |
normal,appearance |
R1506 |
T2249 |
T2246 |
punct |
", ",appearance |
R1507 |
T2250 |
T2246 |
prep |
with,appearance |
R1508 |
T2251 |
T2252 |
npadvmod |
TTD,like |
R1509 |
T2252 |
T2254 |
amod |
like,features |
R1510 |
T2253 |
T2252 |
punct |
-,like |
R1511 |
T2254 |
T2250 |
pobj |
features,with |
R1512 |
T2255 |
T2256 |
amod |
such,as |
R1513 |
T2256 |
T2254 |
prep |
as,features |
R1514 |
T2257 |
T2258 |
amod |
broken,hairs |
R1515 |
T2258 |
T2256 |
pobj |
hairs,as |
R1516 |
T2259 |
T2254 |
acl |
found,features |
R1517 |
T2260 |
T2261 |
advmod |
only,at |
R1518 |
T2261 |
T2259 |
prep |
at,found |
R1519 |
T2262 |
T2263 |
advmod |
very,low |
R1520 |
T2263 |
T2264 |
amod |
low,frequency |
R1521 |
T2264 |
T2261 |
pobj |
frequency,at |
R1522 |
T2265 |
T2266 |
punct |
(,data |
R1523 |
T2266 |
T2239 |
parataxis |
data,revealed |
R1524 |
T2267 |
T2266 |
amod |
unpublished,data |
R1525 |
T2268 |
T2266 |
punct |
),data |
R1526 |
T2269 |
T2239 |
punct |
.,revealed |
R1527 |
T2271 |
T2272 |
compound |
Amino,acid |
R1528 |
T2272 |
T2273 |
compound |
acid,analysis |
R1529 |
T2273 |
T2274 |
nsubj |
analysis,confirmed |
R1530 |
T2275 |
T2276 |
mark |
that,were |
R1531 |
T2276 |
T2274 |
ccomp |
were,confirmed |
R1532 |
T2277 |
T2278 |
compound |
cysteine,levels |
R1533 |
T2278 |
T2276 |
nsubj |
levels,were |
R1534 |
T2279 |
T2278 |
prep |
in,levels |
R1535 |
T2280 |
T2281 |
det |
the,hair |
R1536 |
T2281 |
T2279 |
pobj |
hair,in |
R1537 |
T2282 |
T2281 |
prep |
of,hair |
R1538 |
T2283 |
T2284 |
det |
the,mice |
R1539 |
T2284 |
T2282 |
pobj |
mice,of |
R1540 |
T2285 |
T2286 |
compound |
XpdTTD,†XPCS |
R1541 |
T2286 |
T2284 |
compound |
†XPCS,mice |
R1542 |
T2287 |
T2286 |
punct |
/,†XPCS |