Id |
Subject |
Object |
Predicate |
Lexical cue |
T86 |
7-9 |
IN |
denotes |
of |
T87 |
10-18 |
NN |
denotes |
Progeria |
T88 |
19-21 |
IN |
denotes |
in |
T89 |
22-41 |
NN |
denotes |
Trichothiodystrophy |
T90 |
42-44 |
IN |
denotes |
by |
T91 |
45-55 |
JJ |
denotes |
Homozygous |
T92 |
67-74 |
NNS |
denotes |
Alleles |
T93 |
56-62 |
JJ |
denotes |
Lethal |
T94 |
63-66 |
NN |
denotes |
Xpd |
T95 |
124-332 |
sentence |
denotes |
Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. |
T96 |
125-133 |
IN |
denotes |
Although |
T97 |
225-227 |
VBZ |
denotes |
is |
T98 |
134-142 |
NN |
denotes |
compound |
T99 |
143-157 |
NN |
denotes |
heterozygosity |
T100 |
157-159 |
, |
denotes |
, |
T101 |
159-161 |
CC |
denotes |
or |
T102 |
162-165 |
DT |
denotes |
the |
T103 |
166-174 |
NN |
denotes |
presence |
T104 |
175-177 |
IN |
denotes |
of |
T105 |
178-181 |
CD |
denotes |
two |
T106 |
199-206 |
NNS |
denotes |
alleles |
T107 |
182-191 |
JJ |
denotes |
different |
T108 |
192-198 |
JJ |
denotes |
mutant |
T109 |
207-209 |
IN |
denotes |
of |
T110 |
210-213 |
DT |
denotes |
the |
T111 |
219-223 |
NN |
denotes |
gene |
T112 |
214-218 |
JJ |
denotes |
same |
T113 |
223-225 |
, |
denotes |
, |
T114 |
321-331 |
VBN |
denotes |
documented |
T115 |
228-234 |
JJ |
denotes |
common |
T116 |
235-237 |
IN |
denotes |
in |
T117 |
238-243 |
JJ |
denotes |
human |
T118 |
254-261 |
NN |
denotes |
disease |
T119 |
244-253 |
JJ |
denotes |
recessive |
T120 |
261-263 |
, |
denotes |
, |
T121 |
263-266 |
PRP$ |
denotes |
its |
T122 |
267-276 |
NN |
denotes |
potential |
T123 |
277-279 |
TO |
denotes |
to |
T124 |
280-286 |
VB |
denotes |
impact |
T125 |
287-294 |
NN |
denotes |
disease |
T126 |
295-302 |
NN |
denotes |
outcome |
T127 |
303-306 |
VBZ |
denotes |
has |
T128 |
307-310 |
RB |
denotes |
not |
T129 |
311-315 |
VBN |
denotes |
been |
T130 |
316-320 |
RB |
denotes |
well |
T131 |
331-332 |
. |
denotes |
. |
T132 |
332-487 |
sentence |
denotes |
This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background. |
T133 |
333-337 |
DT |
denotes |
This |
T134 |
338-340 |
VBZ |
denotes |
is |
T135 |
341-345 |
RBS |
denotes |
most |
T136 |
346-352 |
RB |
denotes |
likely |
T137 |
353-360 |
IN |
denotes |
because |
T138 |
361-363 |
IN |
denotes |
of |
T139 |
364-367 |
DT |
denotes |
the |
T140 |
377-387 |
NN |
denotes |
difficulty |
T141 |
368-376 |
JJ |
denotes |
inherent |
T142 |
388-390 |
IN |
denotes |
in |
T143 |
391-405 |
VBG |
denotes |
distinguishing |
T144 |
406-414 |
JJ |
denotes |
specific |
T145 |
425-432 |
NNS |
denotes |
effects |
T146 |
415-424 |
JJ |
denotes |
biallelic |
T147 |
433-437 |
IN |
denotes |
from |
T148 |
438-449 |
NNS |
denotes |
differences |
T149 |
450-452 |
IN |
denotes |
in |
T150 |
453-464 |
NN |
denotes |
environment |
T151 |
465-467 |
CC |
denotes |
or |
T152 |
468-475 |
JJ |
denotes |
genetic |
T153 |
476-486 |
NN |
denotes |
background |
T154 |
486-487 |
. |
denotes |
. |
T155 |
487-666 |
sentence |
denotes |
We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models. |
T156 |
488-490 |
PRP |
denotes |
We |
T157 |
491-500 |
VBD |
denotes |
addressed |
T158 |
501-504 |
DT |
denotes |
the |
T159 |
505-514 |
NN |
denotes |
potential |
T160 |
515-517 |
IN |
denotes |
of |
T161 |
518-527 |
JJ |
denotes |
different |
T162 |
538-545 |
NNS |
denotes |
alleles |
T163 |
528-537 |
JJ |
denotes |
recessive |
T164 |
546-548 |
TO |
denotes |
to |
T165 |
549-559 |
VB |
denotes |
contribute |
T166 |
560-562 |
IN |
denotes |
to |
T167 |
563-566 |
DT |
denotes |
the |
T168 |
577-587 |
NN |
denotes |
pleiotropy |
T169 |
567-576 |
JJ |
denotes |
enigmatic |
T170 |
588-598 |
VBN |
denotes |
associated |
T171 |
599-603 |
IN |
denotes |
with |
T172 |
604-607 |
NN |
denotes |
XPD |
T173 |
618-627 |
NNS |
denotes |
disorders |
T174 |
608-617 |
JJ |
denotes |
recessive |
T175 |
628-630 |
IN |
denotes |
in |
T176 |
631-639 |
NN |
denotes |
compound |
T177 |
659-665 |
NNS |
denotes |
models |
T178 |
640-652 |
JJ |
denotes |
heterozygous |
T179 |
653-658 |
NN |
denotes |
mouse |
T180 |
665-666 |
. |
denotes |
. |
T181 |
666-893 |
sentence |
denotes |
Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria. |
T182 |
667-678 |
NNS |
denotes |
Alterations |
T183 |
766-772 |
VBP |
denotes |
result |
T184 |
679-681 |
IN |
denotes |
in |
T185 |
682-686 |
DT |
denotes |
this |
T186 |
697-705 |
NN |
denotes |
helicase |
T187 |
687-696 |
JJ |
denotes |
essential |
T188 |
705-707 |
, |
denotes |
, |
T189 |
707-711 |
IN |
denotes |
with |
T190 |
712-721 |
NNS |
denotes |
functions |
T191 |
722-724 |
IN |
denotes |
in |
T192 |
725-729 |
CC |
denotes |
both |
T193 |
734-740 |
NN |
denotes |
repair |
T194 |
730-733 |
NN |
denotes |
DNA |
T195 |
741-744 |
CC |
denotes |
and |
T196 |
745-750 |
JJ |
denotes |
basal |
T197 |
751-764 |
NN |
denotes |
transcription |
T198 |
764-766 |
, |
denotes |
, |
T199 |
773-775 |
IN |
denotes |
in |
T200 |
776-783 |
JJ |
denotes |
diverse |
T201 |
784-795 |
NNS |
denotes |
pathologies |
T202 |
796-803 |
VBG |
denotes |
ranging |
T203 |
804-808 |
IN |
denotes |
from |
T204 |
809-817 |
VBN |
denotes |
elevated |
T205 |
821-832 |
NN |
denotes |
sensitivity |
T206 |
818-820 |
NN |
denotes |
UV |
T207 |
833-836 |
CC |
denotes |
and |
T208 |
837-843 |
NN |
denotes |
cancer |
T209 |
844-858 |
NN |
denotes |
predisposition |
T210 |
859-861 |
IN |
denotes |
to |
T211 |
862-873 |
VBN |
denotes |
accelerated |
T212 |
884-892 |
NN |
denotes |
progeria |
T213 |
874-883 |
JJ |
denotes |
segmental |
T214 |
892-893 |
. |
denotes |
. |
T215 |
893-1436 |
sentence |
denotes |
We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii) differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals. |
T216 |
894-896 |
PRP |
denotes |
We |
T217 |
897-903 |
VBP |
denotes |
report |
T218 |
904-905 |
DT |
denotes |
a |
T219 |
906-913 |
NN |
denotes |
variety |
T220 |
914-916 |
IN |
denotes |
of |
T221 |
917-926 |
JJ |
denotes |
biallelic |
T222 |
927-934 |
NNS |
denotes |
effects |
T223 |
935-937 |
IN |
denotes |
on |
T224 |
938-948 |
JJ |
denotes |
organismal |
T225 |
949-958 |
NN |
denotes |
phenotype |
T226 |
959-971 |
JJ |
denotes |
attributable |
T227 |
972-974 |
IN |
denotes |
to |
T228 |
975-987 |
NNS |
denotes |
combinations |
T229 |
988-990 |
IN |
denotes |
of |
T230 |
991-1000 |
JJ |
denotes |
recessive |
T231 |
1005-1012 |
NNS |
denotes |
alleles |
T232 |
1001-1004 |
NN |
denotes |
Xpd |
T233 |
1012-1014 |
, |
denotes |
, |
T234 |
1014-1023 |
VBG |
denotes |
including |
T235 |
1024-1027 |
DT |
denotes |
the |
T236 |
1028-1037 |
NN |
denotes |
following |
T237 |
1037-1039 |
: |
denotes |
: |
T238 |
1039-1040 |
-LRB- |
denotes |
( |
T239 |
1040-1041 |
LS |
denotes |
i |
T240 |
1047-1054 |
NN |
denotes |
ability |
T241 |
1041-1042 |
-RRB- |
denotes |
) |
T242 |
1043-1046 |
DT |
denotes |
the |
T243 |
1055-1057 |
IN |
denotes |
of |
T244 |
1058-1068 |
JJ |
denotes |
homozygous |
T245 |
1080-1087 |
NNS |
denotes |
alleles |
T246 |
1069-1075 |
JJ |
denotes |
lethal |
T247 |
1076-1079 |
NN |
denotes |
Xpd |
T248 |
1088-1090 |
TO |
denotes |
to |
T249 |
1091-1101 |
VB |
denotes |
ameliorate |
T250 |
1102-1103 |
DT |
denotes |
a |
T251 |
1104-1111 |
NN |
denotes |
variety |
T252 |
1112-1114 |
IN |
denotes |
of |
T253 |
1115-1122 |
NN |
denotes |
disease |
T254 |
1123-1131 |
NNS |
denotes |
symptoms |
T255 |
1132-1136 |
WRB |
denotes |
when |
T256 |
1185-1193 |
VBN |
denotes |
supplied |
T257 |
1137-1142 |
PRP$ |
denotes |
their |
T258 |
1173-1181 |
NN |
denotes |
function |
T259 |
1143-1152 |
JJ |
denotes |
essential |
T260 |
1153-1158 |
JJ |
denotes |
basal |
T261 |
1159-1172 |
NN |
denotes |
transcription |
T262 |
1182-1184 |
VBZ |
denotes |
is |
T263 |
1194-1196 |
IN |
denotes |
by |
T264 |
1197-1198 |
DT |
denotes |
a |
T265 |
1225-1231 |
NN |
denotes |
allele |
T266 |
1199-1208 |
JJ |
denotes |
different |
T267 |
1209-1216 |
NN |
denotes |
disease |
T268 |
1217-1224 |
VBG |
denotes |
causing |
T269 |
1216-1217 |
HYPH |
denotes |
- |
T270 |
1231-1233 |
, |
denotes |
, |
T271 |
1233-1234 |
-LRB- |
denotes |
( |
T272 |
1234-1236 |
LS |
denotes |
ii |
T273 |
1285-1294 |
NNS |
denotes |
functions |
T274 |
1236-1237 |
-RRB- |
denotes |
) |
T275 |
1238-1250 |
JJ |
denotes |
differential |
T276 |
1251-1264 |
JJ |
denotes |
developmental |
T277 |
1265-1268 |
CC |
denotes |
and |
T278 |
1269-1275 |
NN |
denotes |
tissue |
T279 |
1276-1284 |
JJ |
denotes |
specific |
T280 |
1275-1276 |
HYPH |
denotes |
- |
T281 |
1295-1297 |
IN |
denotes |
of |
T282 |
1298-1306 |
JJ |
denotes |
distinct |
T283 |
1318-1326 |
NNS |
denotes |
products |
T284 |
1307-1310 |
NN |
denotes |
Xpd |
T285 |
1311-1317 |
NN |
denotes |
allele |
T286 |
1326-1328 |
, |
denotes |
, |
T287 |
1328-1331 |
CC |
denotes |
and |
T288 |
1332-1333 |
-LRB- |
denotes |
( |
T289 |
1333-1336 |
LS |
denotes |
iii |
T290 |
1351-1366 |
NN |
denotes |
complementation |
T291 |
1336-1337 |
-RRB- |
denotes |
) |
T292 |
1338-1350 |
JJ |
denotes |
interallelic |
T293 |
1366-1368 |
, |
denotes |
, |
T294 |
1368-1369 |
DT |
denotes |
a |
T295 |
1370-1380 |
NN |
denotes |
phenomenon |
T296 |
1381-1387 |
RB |
denotes |
rarely |
T297 |
1388-1396 |
VBN |
denotes |
reported |
T298 |
1397-1399 |
IN |
denotes |
at |
T299 |
1400-1410 |
RB |
denotes |
clinically |
T300 |
1411-1419 |
JJ |
denotes |
relevant |
T301 |
1420-1424 |
NNS |
denotes |
loci |
T302 |
1425-1427 |
IN |
denotes |
in |
T303 |
1428-1435 |
NNS |
denotes |
mammals |
T304 |
1435-1436 |
. |
denotes |
. |
T306 |
1437-1440 |
PRP$ |
denotes |
Our |
T307 |
1441-1445 |
NNS |
denotes |
data |
T308 |
1446-1453 |
VBP |
denotes |
suggest |
T309 |
1454-1455 |
DT |
denotes |
a |
T310 |
1456-1469 |
NN |
denotes |
re-evaluation |
T311 |
1470-1472 |
IN |
denotes |
of |
T312 |
1473-1476 |
DT |
denotes |
the |
T313 |
1477-1489 |
NN |
denotes |
contribution |
T314 |
1490-1492 |
IN |
denotes |
of |
T315 |
1493-1494 |
`` |
denotes |
“ |
T316 |
1494-1498 |
JJ |
denotes |
null |
T317 |
1500-1507 |
NNS |
denotes |
alleles |
T318 |
1498-1499 |
'' |
denotes |
” |
T319 |
1508-1510 |
IN |
denotes |
to |
T320 |
1511-1514 |
NN |
denotes |
XPD |
T321 |
1515-1524 |
NNS |
denotes |
disorders |
T322 |
1525-1528 |
CC |
denotes |
and |
T323 |
1529-1538 |
VBP |
denotes |
highlight |
T324 |
1539-1542 |
DT |
denotes |
the |
T325 |
1543-1552 |
NN |
denotes |
potential |
T326 |
1553-1555 |
IN |
denotes |
of |
T327 |
1556-1568 |
NNS |
denotes |
combinations |
T328 |
1569-1571 |
IN |
denotes |
of |
T329 |
1572-1581 |
JJ |
denotes |
recessive |
T330 |
1582-1589 |
NNS |
denotes |
alleles |
T331 |
1590-1592 |
TO |
denotes |
to |
T332 |
1593-1599 |
VB |
denotes |
affect |
T333 |
1600-1604 |
CC |
denotes |
both |
T2572 |
0-6 |
NN |
denotes |
Rescue |
T2573 |
7-9 |
IN |
denotes |
of |
T84 |
0-6 |
NN |
denotes |
Rescue |
T85 |
0-74 |
sentence |
denotes |
Rescue of Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles |
R7 |
T92 |
T90 |
pobj |
Alleles,by |
R8 |
T93 |
T92 |
amod |
Lethal,Alleles |
R9 |
T94 |
T92 |
compound |
Xpd,Alleles |
R11 |
T97 |
T114 |
advcl |
is,documented |
R12 |
T98 |
T99 |
compound |
compound,heterozygosity |
R13 |
T99 |
T97 |
nsubj |
heterozygosity,is |
R14 |
T100 |
T99 |
punct |
", ",heterozygosity |
R15 |
T101 |
T99 |
cc |
or,heterozygosity |
R16 |
T102 |
T103 |
det |
the,presence |
R17 |
T103 |
T99 |
conj |
presence,heterozygosity |
R18 |
T104 |
T103 |
prep |
of,presence |
R19 |
T105 |
T106 |
nummod |
two,alleles |
R20 |
T106 |
T104 |
pobj |
alleles,of |
R21 |
T107 |
T106 |
amod |
different,alleles |
R22 |
T108 |
T106 |
amod |
mutant,alleles |
R23 |
T109 |
T106 |
prep |
of,alleles |
R24 |
T110 |
T111 |
det |
the,gene |
R26 |
T112 |
T111 |
amod |
same,gene |
R27 |
T113 |
T97 |
punct |
", ",is |
R31 |
T118 |
T116 |
pobj |
disease,in |
R32 |
T119 |
T118 |
amod |
recessive,disease |
R51 |
T140 |
T137 |
pobj |
difficulty,because |
R52 |
T141 |
T140 |
amod |
inherent,difficulty |
R56 |
T145 |
T143 |
dobj |
effects,distinguishing |
R57 |
T146 |
T145 |
amod |
biallelic,effects |
R71 |
T162 |
T160 |
pobj |
alleles,of |
R72 |
T163 |
T162 |
amod |
recessive,alleles |
R77 |
T168 |
T166 |
pobj |
pleiotropy,to |
R78 |
T169 |
T168 |
amod |
enigmatic,pleiotropy |
R82 |
T173 |
T171 |
pobj |
disorders,with |
R83 |
T174 |
T173 |
amod |
recessive,disorders |
R86 |
T177 |
T175 |
pobj |
models,in |
R87 |
T178 |
T177 |
amod |
heterozygous,models |
R88 |
T179 |
T177 |
compound |
mouse,models |
R93 |
T186 |
T184 |
pobj |
helicase,in |
R94 |
T187 |
T186 |
amod |
essential,helicase |
R100 |
T193 |
T191 |
pobj |
repair,in |
R101 |
T194 |
T193 |
compound |
DNA,repair |
R112 |
T205 |
T203 |
pobj |
sensitivity,from |
R113 |
T206 |
T205 |
compound |
UV,sensitivity |
R119 |
T212 |
T210 |
pobj |
progeria,to |
R120 |
T213 |
T212 |
amod |
segmental,progeria |
R136 |
T231 |
T229 |
pobj |
alleles,of |
R137 |
T232 |
T231 |
compound |
Xpd,alleles |
R145 |
T240 |
T236 |
appos |
ability,following |
R146 |
T241 |
T239 |
punct |
),i |
R147 |
T242 |
T240 |
det |
the,ability |
R150 |
T245 |
T243 |
pobj |
alleles,of |
R151 |
T246 |
T245 |
amod |
lethal,alleles |
R152 |
T247 |
T245 |
compound |
Xpd,alleles |
R161 |
T256 |
T249 |
advcl |
supplied,ameliorate |
R162 |
T257 |
T258 |
poss |
their,function |
R163 |
T258 |
T256 |
nsubjpass |
function,supplied |
R164 |
T259 |
T258 |
amod |
essential,function |
R165 |
T260 |
T258 |
amod |
basal,function |
R166 |
T261 |
T258 |
compound |
transcription,function |
R167 |
T262 |
T256 |
auxpass |
is,supplied |
R170 |
T265 |
T263 |
pobj |
allele,by |
R171 |
T266 |
T265 |
amod |
different,allele |
R172 |
T267 |
T268 |
npadvmod |
disease,causing |
R174 |
T269 |
T268 |
punct |
-,causing |
R178 |
T273 |
T240 |
conj |
functions,ability |
R179 |
T274 |
T272 |
punct |
),ii |
R180 |
T275 |
T276 |
amod |
differential,developmental |
R181 |
T276 |
T273 |
amod |
developmental,functions |
R182 |
T277 |
T276 |
cc |
and,developmental |
R183 |
T278 |
T279 |
npadvmod |
tissue,specific |
R185 |
T280 |
T279 |
punct |
-,specific |
R188 |
T283 |
T281 |
pobj |
products,of |
R189 |
T284 |
T285 |
compound |
Xpd,allele |
R190 |
T285 |
T283 |
compound |
allele,products |
R195 |
T290 |
T273 |
conj |
complementation,functions |
R196 |
T291 |
T289 |
punct |
),iii |
R197 |
T292 |
T290 |
amod |
interallelic,complementation |
R220 |
T317 |
T314 |
pobj |
alleles,of |
R221 |
T318 |
T317 |
punct |
”,alleles |
R1702 |
T2573 |
T2572 |
prep |
of,Rescue |
R34 |
T121 |
T122 |
poss |
its,potential |
R1 |
T86 |
T84 |
prep |
of,Rescue |
R2 |
T87 |
T86 |
pobj |
Progeria,of |
R3 |
T88 |
T84 |
prep |
in,Rescue |
R4 |
T89 |
T88 |
pobj |
Trichothiodystrophy,in |
R5 |
T90 |
T84 |
prep |
by,Rescue |
R6 |
T91 |
T92 |
amod |
Homozygous,Alleles |
R10 |
T96 |
T97 |
mark |
Although,is |
R25 |
T111 |
T109 |
pobj |
gene,of |
R28 |
T115 |
T97 |
acomp |
common,is |
R29 |
T116 |
T97 |
prep |
in,is |
R30 |
T117 |
T118 |
amod |
human,disease |
R33 |
T120 |
T114 |
punct |
", ",documented |
R35 |
T122 |
T114 |
nsubjpass |
potential,documented |
R36 |
T123 |
T124 |
aux |
to,impact |
R37 |
T124 |
T122 |
acl |
impact,potential |
R38 |
T125 |
T126 |
compound |
disease,outcome |
R39 |
T126 |
T124 |
dobj |
outcome,impact |
R40 |
T127 |
T114 |
aux |
has,documented |
R41 |
T128 |
T114 |
neg |
not,documented |
R42 |
T129 |
T114 |
auxpass |
been,documented |
R43 |
T130 |
T114 |
advmod |
well,documented |
R44 |
T131 |
T114 |
punct |
.,documented |
R45 |
T133 |
T134 |
nsubj |
This,is |
R46 |
T135 |
T136 |
advmod |
most,likely |
R47 |
T136 |
T137 |
advmod |
likely,because |
R48 |
T137 |
T134 |
prep |
because,is |
R49 |
T138 |
T137 |
pcomp |
of,because |
R50 |
T139 |
T140 |
det |
the,difficulty |
R53 |
T142 |
T140 |
prep |
in,difficulty |
R54 |
T143 |
T142 |
pcomp |
distinguishing,in |
R55 |
T144 |
T145 |
amod |
specific,effects |
R58 |
T147 |
T143 |
prep |
from,distinguishing |
R59 |
T148 |
T147 |
pobj |
differences,from |
R60 |
T149 |
T148 |
prep |
in,differences |
R61 |
T150 |
T149 |
pobj |
environment,in |
R62 |
T151 |
T150 |
cc |
or,environment |
R63 |
T152 |
T153 |
amod |
genetic,background |
R64 |
T153 |
T150 |
conj |
background,environment |
R65 |
T154 |
T134 |
punct |
.,is |
R66 |
T156 |
T157 |
nsubj |
We,addressed |
R67 |
T158 |
T159 |
det |
the,potential |
R68 |
T159 |
T157 |
dobj |
potential,addressed |
R69 |
T160 |
T159 |
prep |
of,potential |
R70 |
T161 |
T162 |
amod |
different,alleles |
R73 |
T164 |
T165 |
aux |
to,contribute |
R74 |
T165 |
T159 |
acl |
contribute,potential |
R75 |
T166 |
T165 |
prep |
to,contribute |
R76 |
T167 |
T168 |
det |
the,pleiotropy |
R79 |
T170 |
T168 |
acl |
associated,pleiotropy |
R80 |
T171 |
T170 |
prep |
with,associated |
R81 |
T172 |
T173 |
nmod |
XPD,disorders |
R84 |
T175 |
T170 |
prep |
in,associated |
R85 |
T176 |
T177 |
nmod |
compound,models |
R89 |
T180 |
T157 |
punct |
.,addressed |
R90 |
T182 |
T183 |
nsubj |
Alterations,result |
R91 |
T184 |
T182 |
prep |
in,Alterations |
R92 |
T185 |
T186 |
det |
this,helicase |
R95 |
T188 |
T186 |
punct |
", ",helicase |
R96 |
T189 |
T186 |
prep |
with,helicase |
R97 |
T190 |
T189 |
pobj |
functions,with |
R98 |
T191 |
T190 |
prep |
in,functions |
R99 |
T192 |
T193 |
preconj |
both,repair |
R102 |
T195 |
T193 |
cc |
and,repair |
R103 |
T196 |
T197 |
amod |
basal,transcription |
R104 |
T197 |
T193 |
conj |
transcription,repair |
R105 |
T198 |
T183 |
punct |
", ",result |
R106 |
T199 |
T183 |
prep |
in,result |
R107 |
T200 |
T201 |
amod |
diverse,pathologies |
R108 |
T201 |
T199 |
pobj |
pathologies,in |
R109 |
T202 |
T201 |
acl |
ranging,pathologies |
R110 |
T203 |
T202 |
prep |
from,ranging |
R111 |
T204 |
T205 |
amod |
elevated,sensitivity |
R114 |
T207 |
T205 |
cc |
and,sensitivity |
R115 |
T208 |
T209 |
compound |
cancer,predisposition |
R116 |
T209 |
T205 |
conj |
predisposition,sensitivity |
R117 |
T210 |
T203 |
prep |
to,from |
R118 |
T211 |
T212 |
amod |
accelerated,progeria |
R121 |
T214 |
T183 |
punct |
.,result |
R122 |
T216 |
T217 |
nsubj |
We,report |
R123 |
T218 |
T219 |
det |
a,variety |
R124 |
T219 |
T217 |
dobj |
variety,report |
R125 |
T220 |
T219 |
prep |
of,variety |
R126 |
T221 |
T222 |
amod |
biallelic,effects |
R127 |
T222 |
T220 |
pobj |
effects,of |
R128 |
T223 |
T222 |
prep |
on,effects |
R129 |
T224 |
T225 |
amod |
organismal,phenotype |
R130 |
T225 |
T223 |
pobj |
phenotype,on |
R131 |
T226 |
T222 |
amod |
attributable,effects |
R132 |
T227 |
T226 |
prep |
to,attributable |
R133 |
T228 |
T227 |
pobj |
combinations,to |
R134 |
T229 |
T228 |
prep |
of,combinations |
R135 |
T230 |
T231 |
amod |
recessive,alleles |
R138 |
T233 |
T219 |
punct |
", ",variety |
R139 |
T234 |
T219 |
prep |
including,variety |
R140 |
T235 |
T236 |
det |
the,following |
R141 |
T236 |
T234 |
pobj |
following,including |
R142 |
T237 |
T236 |
punct |
: ,following |
R143 |
T238 |
T239 |
punct |
(,i |
R144 |
T239 |
T240 |
meta |
i,ability |
R148 |
T243 |
T240 |
prep |
of,ability |
R149 |
T244 |
T245 |
amod |
homozygous,alleles |
R153 |
T248 |
T249 |
aux |
to,ameliorate |
R154 |
T249 |
T240 |
acl |
ameliorate,ability |
R155 |
T250 |
T251 |
det |
a,variety |
R156 |
T251 |
T249 |
dobj |
variety,ameliorate |
R157 |
T252 |
T251 |
prep |
of,variety |
R158 |
T253 |
T254 |
compound |
disease,symptoms |
R159 |
T254 |
T252 |
pobj |
symptoms,of |
R160 |
T255 |
T256 |
advmod |
when,supplied |
R168 |
T263 |
T256 |
agent |
by,supplied |
R169 |
T264 |
T265 |
det |
a,allele |
R173 |
T268 |
T265 |
amod |
causing,allele |
R175 |
T270 |
T240 |
punct |
", ",ability |
R176 |
T271 |
T272 |
punct |
(,ii |
R177 |
T272 |
T273 |
meta |
ii,functions |
R184 |
T279 |
T276 |
conj |
specific,developmental |
R186 |
T281 |
T273 |
prep |
of,functions |
R187 |
T282 |
T283 |
amod |
distinct,products |
R191 |
T286 |
T273 |
punct |
", ",functions |
R192 |
T287 |
T273 |
cc |
and,functions |
R193 |
T288 |
T289 |
punct |
(,iii |
R194 |
T289 |
T290 |
meta |
iii,complementation |
R198 |
T293 |
T290 |
punct |
", ",complementation |
R199 |
T294 |
T295 |
det |
a,phenomenon |
R200 |
T295 |
T290 |
appos |
phenomenon,complementation |
R201 |
T296 |
T297 |
advmod |
rarely,reported |
R202 |
T297 |
T295 |
acl |
reported,phenomenon |
R203 |
T298 |
T297 |
prep |
at,reported |
R204 |
T299 |
T300 |
advmod |
clinically,relevant |
R205 |
T300 |
T301 |
amod |
relevant,loci |
R206 |
T301 |
T298 |
pobj |
loci,at |
R207 |
T302 |
T301 |
prep |
in,loci |
R208 |
T303 |
T302 |
pobj |
mammals,in |
R209 |
T304 |
T217 |
punct |
.,report |
R210 |
T306 |
T307 |
poss |
Our,data |
R211 |
T307 |
T308 |
nsubj |
data,suggest |
R212 |
T309 |
T310 |
det |
a,re-evaluation |
R213 |
T310 |
T308 |
dobj |
re-evaluation,suggest |
R214 |
T311 |
T310 |
prep |
of,re-evaluation |
R215 |
T312 |
T313 |
det |
the,contribution |
R216 |
T313 |
T311 |
pobj |
contribution,of |
R217 |
T314 |
T313 |
prep |
of,contribution |
R218 |
T315 |
T314 |
punct |
“,of |
R219 |
T316 |
T317 |
amod |
null,alleles |
R222 |
T319 |
T313 |
prep |
to,contribution |
R223 |
T320 |
T321 |
compound |
XPD,disorders |
R224 |
T321 |
T319 |
pobj |
disorders,to |
R225 |
T322 |
T308 |
cc |
and,suggest |
R226 |
T323 |
T308 |
conj |
highlight,suggest |
R227 |
T324 |
T325 |
det |
the,potential |
R228 |
T325 |
T323 |
dobj |
potential,highlight |
R229 |
T326 |
T325 |
prep |
of,potential |
R230 |
T327 |
T326 |
pobj |
combinations,of |
R231 |
T328 |
T327 |
prep |
of,combinations |
R232 |
T329 |
T330 |
amod |
recessive,alleles |
R233 |
T330 |
T328 |
pobj |
alleles,of |
R234 |
T331 |
T332 |
aux |
to,affect |
R235 |
T332 |
T325 |
acl |
affect,potential |