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Id Subject Object Predicate Lexical cue
T86 7-9 IN denotes of
T87 10-18 NN denotes Progeria
T88 19-21 IN denotes in
T89 22-41 NN denotes Trichothiodystrophy
T90 42-44 IN denotes by
T91 45-55 JJ denotes Homozygous
T92 67-74 NNS denotes Alleles
T93 56-62 JJ denotes Lethal
T94 63-66 NN denotes Xpd
T95 124-332 sentence denotes Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented.
T96 125-133 IN denotes Although
T97 225-227 VBZ denotes is
T98 134-142 NN denotes compound
T99 143-157 NN denotes heterozygosity
T100 157-159 , denotes ,
T101 159-161 CC denotes or
T102 162-165 DT denotes the
T103 166-174 NN denotes presence
T104 175-177 IN denotes of
T105 178-181 CD denotes two
T106 199-206 NNS denotes alleles
T107 182-191 JJ denotes different
T108 192-198 JJ denotes mutant
T109 207-209 IN denotes of
T110 210-213 DT denotes the
T111 219-223 NN denotes gene
T112 214-218 JJ denotes same
T113 223-225 , denotes ,
T114 321-331 VBN denotes documented
T115 228-234 JJ denotes common
T116 235-237 IN denotes in
T117 238-243 JJ denotes human
T118 254-261 NN denotes disease
T119 244-253 JJ denotes recessive
T120 261-263 , denotes ,
T121 263-266 PRP$ denotes its
T122 267-276 NN denotes potential
T123 277-279 TO denotes to
T124 280-286 VB denotes impact
T125 287-294 NN denotes disease
T126 295-302 NN denotes outcome
T127 303-306 VBZ denotes has
T128 307-310 RB denotes not
T129 311-315 VBN denotes been
T130 316-320 RB denotes well
T131 331-332 . denotes .
T132 332-487 sentence denotes This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background.
T133 333-337 DT denotes This
T134 338-340 VBZ denotes is
T135 341-345 RBS denotes most
T136 346-352 RB denotes likely
T137 353-360 IN denotes because
T138 361-363 IN denotes of
T139 364-367 DT denotes the
T140 377-387 NN denotes difficulty
T141 368-376 JJ denotes inherent
T142 388-390 IN denotes in
T143 391-405 VBG denotes distinguishing
T144 406-414 JJ denotes specific
T145 425-432 NNS denotes effects
T146 415-424 JJ denotes biallelic
T147 433-437 IN denotes from
T148 438-449 NNS denotes differences
T149 450-452 IN denotes in
T150 453-464 NN denotes environment
T151 465-467 CC denotes or
T152 468-475 JJ denotes genetic
T153 476-486 NN denotes background
T154 486-487 . denotes .
T155 487-666 sentence denotes We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models.
T156 488-490 PRP denotes We
T157 491-500 VBD denotes addressed
T158 501-504 DT denotes the
T159 505-514 NN denotes potential
T160 515-517 IN denotes of
T161 518-527 JJ denotes different
T162 538-545 NNS denotes alleles
T163 528-537 JJ denotes recessive
T164 546-548 TO denotes to
T165 549-559 VB denotes contribute
T166 560-562 IN denotes to
T167 563-566 DT denotes the
T168 577-587 NN denotes pleiotropy
T169 567-576 JJ denotes enigmatic
T170 588-598 VBN denotes associated
T171 599-603 IN denotes with
T172 604-607 NN denotes XPD
T173 618-627 NNS denotes disorders
T174 608-617 JJ denotes recessive
T175 628-630 IN denotes in
T176 631-639 NN denotes compound
T177 659-665 NNS denotes models
T178 640-652 JJ denotes heterozygous
T179 653-658 NN denotes mouse
T180 665-666 . denotes .
T181 666-893 sentence denotes Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria.
T182 667-678 NNS denotes Alterations
T183 766-772 VBP denotes result
T184 679-681 IN denotes in
T185 682-686 DT denotes this
T186 697-705 NN denotes helicase
T187 687-696 JJ denotes essential
T188 705-707 , denotes ,
T189 707-711 IN denotes with
T190 712-721 NNS denotes functions
T191 722-724 IN denotes in
T192 725-729 CC denotes both
T193 734-740 NN denotes repair
T194 730-733 NN denotes DNA
T195 741-744 CC denotes and
T196 745-750 JJ denotes basal
T197 751-764 NN denotes transcription
T198 764-766 , denotes ,
T199 773-775 IN denotes in
T200 776-783 JJ denotes diverse
T201 784-795 NNS denotes pathologies
T202 796-803 VBG denotes ranging
T203 804-808 IN denotes from
T204 809-817 VBN denotes elevated
T205 821-832 NN denotes sensitivity
T206 818-820 NN denotes UV
T207 833-836 CC denotes and
T208 837-843 NN denotes cancer
T209 844-858 NN denotes predisposition
T210 859-861 IN denotes to
T211 862-873 VBN denotes accelerated
T212 884-892 NN denotes progeria
T213 874-883 JJ denotes segmental
T214 892-893 . denotes .
T215 893-1436 sentence denotes We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii) differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.
T216 894-896 PRP denotes We
T217 897-903 VBP denotes report
T218 904-905 DT denotes a
T219 906-913 NN denotes variety
T220 914-916 IN denotes of
T221 917-926 JJ denotes biallelic
T222 927-934 NNS denotes effects
T223 935-937 IN denotes on
T224 938-948 JJ denotes organismal
T225 949-958 NN denotes phenotype
T226 959-971 JJ denotes attributable
T227 972-974 IN denotes to
T228 975-987 NNS denotes combinations
T229 988-990 IN denotes of
T230 991-1000 JJ denotes recessive
T231 1005-1012 NNS denotes alleles
T232 1001-1004 NN denotes Xpd
T233 1012-1014 , denotes ,
T234 1014-1023 VBG denotes including
T235 1024-1027 DT denotes the
T236 1028-1037 NN denotes following
T237 1037-1039 : denotes :
T238 1039-1040 -LRB- denotes (
T239 1040-1041 LS denotes i
T240 1047-1054 NN denotes ability
T241 1041-1042 -RRB- denotes )
T242 1043-1046 DT denotes the
T243 1055-1057 IN denotes of
T244 1058-1068 JJ denotes homozygous
T245 1080-1087 NNS denotes alleles
T246 1069-1075 JJ denotes lethal
T247 1076-1079 NN denotes Xpd
T248 1088-1090 TO denotes to
T249 1091-1101 VB denotes ameliorate
T250 1102-1103 DT denotes a
T251 1104-1111 NN denotes variety
T252 1112-1114 IN denotes of
T253 1115-1122 NN denotes disease
T254 1123-1131 NNS denotes symptoms
T255 1132-1136 WRB denotes when
T256 1185-1193 VBN denotes supplied
T257 1137-1142 PRP$ denotes their
T258 1173-1181 NN denotes function
T259 1143-1152 JJ denotes essential
T260 1153-1158 JJ denotes basal
T261 1159-1172 NN denotes transcription
T262 1182-1184 VBZ denotes is
T263 1194-1196 IN denotes by
T264 1197-1198 DT denotes a
T265 1225-1231 NN denotes allele
T266 1199-1208 JJ denotes different
T267 1209-1216 NN denotes disease
T268 1217-1224 VBG denotes causing
T269 1216-1217 HYPH denotes -
T270 1231-1233 , denotes ,
T271 1233-1234 -LRB- denotes (
T272 1234-1236 LS denotes ii
T273 1285-1294 NNS denotes functions
T274 1236-1237 -RRB- denotes )
T275 1238-1250 JJ denotes differential
T276 1251-1264 JJ denotes developmental
T277 1265-1268 CC denotes and
T278 1269-1275 NN denotes tissue
T279 1276-1284 JJ denotes specific
T280 1275-1276 HYPH denotes -
T281 1295-1297 IN denotes of
T282 1298-1306 JJ denotes distinct
T283 1318-1326 NNS denotes products
T284 1307-1310 NN denotes Xpd
T285 1311-1317 NN denotes allele
T286 1326-1328 , denotes ,
T287 1328-1331 CC denotes and
T288 1332-1333 -LRB- denotes (
T289 1333-1336 LS denotes iii
T290 1351-1366 NN denotes complementation
T291 1336-1337 -RRB- denotes )
T292 1338-1350 JJ denotes interallelic
T293 1366-1368 , denotes ,
T294 1368-1369 DT denotes a
T295 1370-1380 NN denotes phenomenon
T296 1381-1387 RB denotes rarely
T297 1388-1396 VBN denotes reported
T298 1397-1399 IN denotes at
T299 1400-1410 RB denotes clinically
T300 1411-1419 JJ denotes relevant
T301 1420-1424 NNS denotes loci
T302 1425-1427 IN denotes in
T303 1428-1435 NNS denotes mammals
T304 1435-1436 . denotes .
T305 1436-1662 sentence denotes Our data suggest a re-evaluation of the contribution of “null” alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals.
T306 1437-1440 PRP$ denotes Our
T307 1441-1445 NNS denotes data
T308 1446-1453 VBP denotes suggest
T309 1454-1455 DT denotes a
T310 1456-1469 NN denotes re-evaluation
T311 1470-1472 IN denotes of
T312 1473-1476 DT denotes the
T313 1477-1489 NN denotes contribution
T314 1490-1492 IN denotes of
T315 1493-1494 `` denotes “
T316 1494-1498 JJ denotes null
T317 1500-1507 NNS denotes alleles
T318 1498-1499 '' denotes ”
T319 1508-1510 IN denotes to
T320 1511-1514 NN denotes XPD
T321 1515-1524 NNS denotes disorders
T322 1525-1528 CC denotes and
T323 1529-1538 VBP denotes highlight
T324 1539-1542 DT denotes the
T325 1543-1552 NN denotes potential
T326 1553-1555 IN denotes of
T327 1556-1568 NNS denotes combinations
T328 1569-1571 IN denotes of
T329 1572-1581 JJ denotes recessive
T330 1582-1589 NNS denotes alleles
T331 1590-1592 TO denotes to
T332 1593-1599 VB denotes affect
T333 1600-1604 CC denotes both
T334 1640-1650 NN denotes plasticity
T335 1605-1611 JJ denotes normal
T336 1612-1615 CC denotes and
T337 1616-1628 JJ denotes pathological
T338 1629-1639 JJ denotes phenotypic
T339 1651-1653 IN denotes in
T340 1654-1661 NNS denotes mammals
T341 1661-1662 . denotes .
T565 1900-1912 JJ denotes Interallelic
T566 1913-1928 NN denotes complementation
T567 1932-1939 VBN denotes defined
T568 1929-1931 VBZ denotes is
T569 1940-1942 IN denotes as
T570 1943-1946 DT denotes the
T571 1947-1954 NN denotes ability
T572 1955-1957 IN denotes of
T573 1958-1961 CD denotes two
T574 1985-1992 NNS denotes alleles
T575 1962-1976 RB denotes differentially
T576 1977-1984 VBN denotes mutated
T577 1993-1995 TO denotes to
T578 1996-2004 VB denotes function
T579 2005-2011 RBR denotes better
T580 2012-2020 RB denotes together
T581 2021-2025 IN denotes than
T582 2033-2036 MD denotes can
T583 2026-2032 DT denotes either
T584 2037-2039 IN denotes on
T585 2040-2043 PRP$ denotes its
T586 2044-2047 JJ denotes own
T587 2047-2048 . denotes .
T588 2048-2195 sentence denotes Despite its near universality in lower organisms [1], its potential to contribute to clinical heterogeneity in human disease is seldom considered.
T589 2049-2056 IN denotes Despite
T590 2184-2194 VBN denotes considered
T591 2057-2060 PRP$ denotes its
T592 2066-2078 NN denotes universality
T593 2061-2065 JJ denotes near
T594 2079-2081 IN denotes in
T595 2082-2087 JJR denotes lower
T596 2088-2097 NNS denotes organisms
T597 2098-2099 -LRB- denotes [
T598 2099-2100 CD denotes 1
T599 2100-2101 -RRB- denotes ]
T600 2101-2103 , denotes ,
T601 2103-2106 PRP$ denotes its
T602 2107-2116 NN denotes potential
T603 2117-2119 TO denotes to
T604 2120-2130 VB denotes contribute
T605 2131-2133 IN denotes to
T606 2134-2142 JJ denotes clinical
T607 2143-2156 NN denotes heterogeneity
T608 2157-2159 IN denotes in
T609 2160-2165 JJ denotes human
T610 2166-2173 NN denotes disease
T611 2174-2176 VBZ denotes is
T612 2177-2183 RB denotes seldom
T613 2194-2195 . denotes .
T614 2195-2523 sentence denotes Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5].
T615 2196-2204 NN denotes Evidence
T616 2268-2275 VBN denotes limited
T617 2205-2207 IN denotes of
T618 2208-2220 JJ denotes interallelic
T619 2221-2236 NN denotes complementation
T620 2237-2239 IN denotes at
T621 2240-2250 RB denotes clinically
T622 2251-2259 JJ denotes relevant
T623 2260-2264 NNS denotes loci
T624 2265-2267 VBZ denotes is
T625 2276-2278 IN denotes to
T626 2279-2290 JJ denotes biochemical
T627 2306-2313 NNS denotes studies
T628 2291-2294 CC denotes and
T629 2295-2299 NN denotes cell
T630 2300-2305 VBN denotes based
T631 2299-2300 HYPH denotes -
T632 2314-2316 IN denotes of
T633 2317-2318 DT denotes a
T634 2319-2326 NN denotes handful
T635 2327-2329 IN denotes of
T636 2330-2339 JJ denotes metabolic
T637 2340-2349 NNS denotes disorders
T638 2350-2354 IN denotes with
T639 2355-2362 NNS denotes defects
T640 2363-2365 IN denotes in
T641 2366-2373 NNS denotes enzymes
T642 2374-2383 VBG denotes including
T643 2384-2392 NN denotes propinyl
T644 2393-2396 NN denotes CoA
T645 2392-2393 HYPH denotes -
T646 2397-2408 NN denotes carboxylase
T647 2409-2410 -LRB- denotes [
T648 2410-2411 CD denotes 2
T649 2411-2412 -RRB- denotes ]
T650 2412-2414 , denotes ,
T651 2414-2431 NN denotes argininosuccinate
T652 2432-2437 NN denotes lyase
T653 2438-2439 -LRB- denotes [
T654 2439-2440 CD denotes 3
T655 2440-2441 -RRB- denotes ]
T656 2441-2443 , denotes ,
T657 2443-2452 NN denotes galactose
T658 2455-2464 NN denotes phosphate
T659 2452-2453 HYPH denotes -
T660 2453-2454 CD denotes 1
T661 2454-2455 HYPH denotes -
T662 2465-2484 NN denotes uridylyltransferase
T663 2485-2486 -LRB- denotes [
T664 2486-2487 CD denotes 4
T665 2487-2488 -RRB- denotes ]
T666 2488-2490 , denotes ,
T667 2490-2493 CC denotes and
T668 2494-2507 NN denotes methylmalonyl
T669 2512-2518 NN denotes mutase
T670 2508-2511 NN denotes CoA
T671 2519-2520 -LRB- denotes [
T672 2520-2521 CD denotes 5
T673 2521-2522 -RRB- denotes ]
T674 2522-2523 . denotes .
T675 2523-2618 sentence denotes Compound heterozygotes are individuals carrying two different mutant alleles of the same gene.
T676 2524-2532 JJ denotes Compound
T677 2533-2546 NNS denotes heterozygotes
T678 2547-2550 VBP denotes are
T679 2551-2562 NNS denotes individuals
T680 2563-2571 VBG denotes carrying
T681 2572-2575 CD denotes two
T682 2593-2600 NNS denotes alleles
T683 2576-2585 JJ denotes different
T684 2586-2592 JJ denotes mutant
T685 2601-2603 IN denotes of
T686 2604-2607 DT denotes the
T687 2613-2617 NN denotes gene
T688 2608-2612 JJ denotes same
T689 2617-2618 . denotes .
T690 2618-2847 sentence denotes In the absence of a dominant (wild-type [wt]) allele, genetic interactions between recessive alleles (referred to here as “biallelic” effects) could result in different phenotypic outcomes including interallelic complementation.
T691 2619-2621 IN denotes In
T692 2768-2774 VB denotes result
T693 2622-2625 DT denotes the
T694 2626-2633 NN denotes absence
T695 2634-2636 IN denotes of
T696 2637-2638 DT denotes a
T697 2665-2671 NN denotes allele
T698 2639-2647 JJ denotes dominant
T699 2648-2649 -LRB- denotes (
T700 2649-2653 JJ denotes wild
T701 2654-2658 NN denotes type
T702 2653-2654 HYPH denotes -
T703 2659-2660 -LRB- denotes [
T704 2660-2662 NN denotes wt
T705 2662-2663 -RRB- denotes ]
T706 2663-2664 -RRB- denotes )
T707 2671-2673 , denotes ,
T708 2673-2680 JJ denotes genetic
T709 2681-2693 NNS denotes interactions
T710 2694-2701 IN denotes between
T711 2702-2711 JJ denotes recessive
T712 2712-2719 NNS denotes alleles
T713 2720-2721 -LRB- denotes (
T714 2721-2729 VBN denotes referred
T715 2730-2732 IN denotes to
T716 2733-2737 RB denotes here
T717 2738-2740 IN denotes as
T718 2741-2742 `` denotes “
T719 2742-2751 JJ denotes biallelic
T720 2753-2760 NNS denotes effects
T721 2751-2752 '' denotes ”
T722 2760-2761 -RRB- denotes )
T723 2762-2767 MD denotes could
T724 2775-2777 IN denotes in
T725 2778-2787 JJ denotes different
T726 2799-2807 NNS denotes outcomes
T727 2788-2798 JJ denotes phenotypic
T728 2808-2817 VBG denotes including
T729 2818-2830 JJ denotes interallelic
T730 2831-2846 NN denotes complementation
T731 2846-2847 . denotes .
T732 2847-3183 sentence denotes Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background.
T733 2848-2856 IN denotes Although
T734 2928-2934 VB denotes create
T735 2857-2869 NN denotes amelioration
T736 2870-2872 IN denotes of
T737 2873-2880 NN denotes disease
T738 2881-2889 NNS denotes symptoms
T739 2890-2892 IN denotes by
T740 2893-2905 JJ denotes interallelic
T741 2906-2921 NN denotes complementation
T742 2922-2927 MD denotes would
T743 3087-3093 VBN denotes caused
T744 2935-2937 DT denotes an
T745 2952-2956 NN denotes bias
T746 2938-2951 NN denotes ascertainment
T747 2957-2959 IN denotes in
T748 2960-2963 DT denotes the
T749 2964-2970 NN denotes clinic
T750 2970-2972 , denotes ,
T751 2972-2975 DT denotes the
T752 2976-2980 NN denotes lack
T753 2981-2983 IN denotes of
T754 2984-2992 NN denotes evidence
T755 2993-3003 VBG denotes concerning
T756 3004-3016 JJ denotes interallelic
T757 3017-3032 NN denotes complementation
T758 3033-3035 CC denotes or
T759 3036-3041 JJ denotes other
T760 3052-3059 NNS denotes effects
T761 3042-3051 JJ denotes biallelic
T762 3060-3062 IN denotes in
T763 3063-3068 JJ denotes human
T764 3069-3076 NN denotes disease
T765 3077-3079 VBZ denotes is
T766 3080-3086 RB denotes likely
T767 3094-3096 IN denotes by
T768 3097-3100 DT denotes the
T769 3101-3111 NN denotes difficulty
T770 3112-3114 IN denotes in
T771 3115-3129 VBG denotes distinguishing
T772 3130-3134 JJ denotes such
T773 3135-3142 NNS denotes effects
T774 3143-3147 IN denotes from
T775 3148-3159 NN denotes environment
T776 3160-3163 CC denotes and
T777 3164-3171 JJ denotes genetic
T778 3172-3182 NN denotes background
T779 3182-3183 . denotes .
T780 3183-3484 sentence denotes XPD encodes one of the two helicase components of basal transcription/DNA repair factor IIH (TFIIH), a ten-subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].
T781 3184-3187 NN denotes XPD
T782 3188-3195 VBZ denotes encodes
T783 3196-3199 CD denotes one
T784 3200-3202 IN denotes of
T785 3203-3206 DT denotes the
T786 3220-3230 NNS denotes components
T787 3207-3210 CD denotes two
T788 3211-3219 NN denotes helicase
T789 3231-3233 IN denotes of
T790 3234-3239 JJ denotes basal
T791 3272-3275 NN denotes IIH
T792 3240-3253 NN denotes transcription
T793 3253-3254 HYPH denotes /
T794 3254-3257 NN denotes DNA
T795 3258-3264 NN denotes repair
T796 3265-3271 NN denotes factor
T797 3276-3277 -LRB- denotes (
T798 3277-3282 NN denotes TFIIH
T799 3282-3283 -RRB- denotes )
T800 3283-3285 , denotes ,
T801 3285-3286 DT denotes a
T802 3316-3323 NN denotes complex
T803 3287-3290 CD denotes ten
T804 3291-3298 NN denotes subunit
T805 3290-3291 HYPH denotes -
T806 3298-3300 , denotes ,
T807 3300-3315 JJ denotes multifunctional
T808 3324-3328 WDT denotes that
T809 3329-3331 VBZ denotes is
T810 3332-3341 JJ denotes essential
T811 3342-3345 IN denotes for
T812 3346-3354 JJ denotes multiple
T813 3355-3364 NNS denotes processes
T814 3364-3366 , denotes ,
T815 3366-3375 VBG denotes including
T816 3376-3381 JJ denotes basal
T817 3396-3406 NN denotes initiation
T818 3382-3395 NN denotes transcription
T819 3407-3410 CC denotes and
T820 3411-3414 NN denotes DNA
T821 3422-3428 NN denotes repair
T822 3415-3421 NN denotes damage
T823 3429-3432 IN denotes via
T824 3433-3436 DT denotes the
T825 3470-3477 NN denotes pathway
T826 3437-3447 NN denotes nucleotide
T827 3457-3463 NN denotes repair
T828 3448-3456 NN denotes excision
T829 3464-3465 -LRB- denotes (
T830 3465-3468 NN denotes NER
T831 3468-3469 -RRB- denotes )
T832 3478-3479 -LRB- denotes [
T833 3481-3482 CD denotes 7
T834 3479-3480 CD denotes 6
T835 3480-3481 , denotes ,
T836 3482-3483 -RRB- denotes ]
T837 3483-3484 . denotes .
T838 3484-3714 sentence denotes Alterations in XPD resulting in defective TFIIH function are associated with UV-sensitive, multisystem disorders including xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD) [8–10].
T839 3485-3496 NNS denotes Alterations
T840 3546-3556 VBN denotes associated
T841 3497-3499 IN denotes in
T842 3500-3503 NN denotes XPD
T843 3504-3513 VBG denotes resulting
T844 3514-3516 IN denotes in
T845 3517-3526 JJ denotes defective
T846 3533-3541 NN denotes function
T847 3527-3532 NN denotes TFIIH
T848 3542-3545 VBP denotes are
T849 3557-3561 IN denotes with
T850 3562-3564 NN denotes UV
T851 3565-3574 JJ denotes sensitive
T852 3564-3565 HYPH denotes -
T853 3588-3597 NNS denotes disorders
T854 3574-3576 , denotes ,
T855 3576-3587 JJ denotes multisystem
T856 3598-3607 VBG denotes including
T857 3608-3617 NN denotes xeroderma
T858 3618-3629 NN denotes pigmentosum
T859 3630-3631 -LRB- denotes (
T860 3631-3633 NN denotes XP
T861 3633-3634 -RRB- denotes )
T862 3634-3636 , denotes ,
T863 3636-3638 NN denotes XP
T864 3639-3647 VBN denotes combined
T865 3648-3652 IN denotes with
T866 3653-3661 NN denotes Cockayne
T867 3662-3670 NN denotes syndrome
T868 3671-3672 -LRB- denotes (
T869 3672-3674 NN denotes CS
T870 3674-3675 -RRB- denotes )
T871 3675-3677 , denotes ,
T872 3677-3680 CC denotes and
T873 3681-3700 NN denotes trichothiodystrophy
T874 3701-3702 -LRB- denotes (
T875 3702-3705 NN denotes TTD
T876 3705-3706 -RRB- denotes )
T877 3707-3708 -LRB- denotes [
T878 3708-3709 CD denotes 8
T879 3709-3710 SYM denotes –
T880 3710-3712 CD denotes 10
T881 3712-3713 -RRB- denotes ]
T882 3713-3714 . denotes .
T883 3714-3826 sentence denotes XP is marked by sun-induced pigmentation anomalies and a greater than 1,000-fold elevation in skin cancer risk.
T884 3715-3717 NN denotes XP
T885 3721-3727 VBN denotes marked
T886 3718-3720 VBZ denotes is
T887 3728-3730 IN denotes by
T888 3731-3734 NN denotes sun
T889 3735-3742 VBN denotes induced
T890 3734-3735 HYPH denotes -
T891 3756-3765 NNS denotes anomalies
T892 3743-3755 NN denotes pigmentation
T893 3766-3769 CC denotes and
T894 3770-3771 DT denotes a
T895 3796-3805 NN denotes elevation
T896 3772-3779 JJR denotes greater
T897 3785-3790 CD denotes 1,000
T898 3780-3784 IN denotes than
T899 3791-3795 RB denotes fold
T900 3790-3791 HYPH denotes -
T901 3806-3808 IN denotes in
T902 3809-3813 NN denotes skin
T903 3814-3820 NN denotes cancer
T904 3821-3825 NN denotes risk
T905 3825-3826 . denotes .
T906 3826-3916 sentence denotes Severe cases can also present with growth retardation and primary neurodegeneration [11].
T907 3827-3833 JJ denotes Severe
T908 3834-3839 NNS denotes cases
T909 3849-3856 VB denotes present
T910 3840-3843 MD denotes can
T911 3844-3848 RB denotes also
T912 3857-3861 IN denotes with
T913 3862-3868 NN denotes growth
T914 3869-3880 NN denotes retardation
T915 3881-3884 CC denotes and
T916 3885-3892 JJ denotes primary
T917 3893-3910 NN denotes neurodegeneration
T918 3911-3912 -LRB- denotes [
T919 3912-3914 CD denotes 11
T920 3914-3915 -RRB- denotes ]
T921 3915-3916 . denotes .
T922 3916-4151 sentence denotes CS and TTD, on the other hand, are segmental progeroid disorders characterised by progressive post-natal growth failure and primary demyelination resulting in severe neurodysfunction, but without a clear cancer predisposition [12–15].
T923 3917-3919 NN denotes CS
T924 3948-3951 VBP denotes are
T925 3920-3923 CC denotes and
T926 3924-3927 NN denotes TTD
T927 3927-3929 , denotes ,
T928 3929-3931 IN denotes on
T929 3932-3935 DT denotes the
T930 3942-3946 NN denotes hand
T931 3936-3941 JJ denotes other
T932 3946-3948 , denotes ,
T933 3952-3961 JJ denotes segmental
T934 3972-3981 NNS denotes disorders
T935 3962-3971 JJ denotes progeroid
T936 3982-3995 VBN denotes characterised
T937 3996-3998 IN denotes by
T938 3999-4010 JJ denotes progressive
T939 4029-4036 NN denotes failure
T940 4011-4021 JJ denotes post-natal
T941 4022-4028 NN denotes growth
T942 4037-4040 CC denotes and
T943 4041-4048 JJ denotes primary
T944 4049-4062 NN denotes demyelination
T945 4063-4072 VBG denotes resulting
T946 4073-4075 IN denotes in
T947 4076-4082 JJ denotes severe
T948 4083-4099 NN denotes neurodysfunction
T949 4099-4101 , denotes ,
T950 4101-4104 CC denotes but
T951 4105-4112 IN denotes without
T952 4113-4114 DT denotes a
T953 4128-4142 NN denotes predisposition
T954 4115-4120 JJ denotes clear
T955 4121-4127 NN denotes cancer
T956 4143-4144 -LRB- denotes [
T957 4144-4146 CD denotes 12
T958 4146-4147 SYM denotes –
T959 4147-4149 CD denotes 15
T960 4149-4150 -RRB- denotes ]
T961 4150-4151 . denotes .
T962 4151-4339 sentence denotes Patients with TTD additionally display hallmark sulphur-deficient brittle hair and nails and scaling skin [13], resulting from a basal transcription defect in specific cell types [16,17].
T963 4152-4160 NNS denotes Patients
T964 4183-4190 VBP denotes display
T965 4161-4165 IN denotes with
T966 4166-4169 NN denotes TTD
T967 4170-4182 RB denotes additionally
T968 4191-4199 NN denotes hallmark
T969 4226-4230 NN denotes hair
T970 4200-4207 NN denotes sulphur
T971 4208-4217 JJ denotes deficient
T972 4207-4208 HYPH denotes -
T973 4218-4225 JJ denotes brittle
T974 4231-4234 CC denotes and
T975 4235-4240 NNS denotes nails
T976 4241-4244 CC denotes and
T977 4245-4252 JJ denotes scaling
T978 4253-4257 NN denotes skin
T979 4258-4259 -LRB- denotes [
T980 4259-4261 CD denotes 13
T981 4261-4262 -RRB- denotes ]
T982 4262-4264 , denotes ,
T983 4264-4273 VBG denotes resulting
T984 4274-4278 IN denotes from
T985 4279-4280 DT denotes a
T986 4301-4307 NN denotes defect
T987 4281-4286 JJ denotes basal
T988 4287-4300 NN denotes transcription
T989 4308-4310 IN denotes in
T990 4311-4319 JJ denotes specific
T991 4325-4330 NNS denotes types
T992 4320-4324 NN denotes cell
T993 4331-4332 -LRB- denotes [
T994 4335-4337 CD denotes 17
T995 4332-4334 CD denotes 16
T996 4334-4335 , denotes ,
T997 4337-4338 -RRB- denotes ]
T998 4338-4339 . denotes .
T999 4339-4505 sentence denotes A related disorder with the cancer predisposition of XP combined with the neurodevelopmental complications of CS (XPCS), although rare, has also been described [18].
T1000 4340-4341 DT denotes A
T1001 4350-4358 NN denotes disorder
T1002 4342-4349 JJ denotes related
T1003 4490-4499 VBN denotes described
T1004 4359-4363 IN denotes with
T1005 4364-4367 DT denotes the
T1006 4375-4389 NN denotes predisposition
T1007 4368-4374 NN denotes cancer
T1008 4390-4392 IN denotes of
T1009 4393-4395 NN denotes XP
T1010 4396-4404 VBN denotes combined
T1011 4405-4409 IN denotes with
T1012 4410-4413 DT denotes the
T1013 4433-4446 NNS denotes complications
T1014 4414-4432 JJ denotes neurodevelopmental
T1015 4447-4449 IN denotes of
T1016 4450-4452 NN denotes CS
T1017 4453-4454 -LRB- denotes (
T1018 4454-4458 NN denotes XPCS
T1019 4458-4459 -RRB- denotes )
T1020 4459-4461 , denotes ,
T1021 4461-4469 IN denotes although
T1022 4470-4474 JJ denotes rare
T1023 4474-4476 , denotes ,
T1024 4476-4479 VBZ denotes has
T1025 4480-4484 RB denotes also
T1026 4485-4489 VBN denotes been
T1027 4500-4501 -LRB- denotes [
T1028 4501-4503 CD denotes 18
T1029 4503-4504 -RRB- denotes ]
T1030 4504-4505 . denotes .
T1031 4505-4687 sentence denotes Many XPD mutations are associated with an exclusive disease phenotype (e.g., XPDR722W with TTD and XPDR683W with XP) and are thus viewed as causative of the corresponding syndromes.
T1032 4506-4510 JJ denotes Many
T1033 4515-4524 NNS denotes mutations
T1034 4511-4514 NN denotes XPD
T1035 4529-4539 VBN denotes associated
T1036 4525-4528 VBP denotes are
T1037 4540-4544 IN denotes with
T1038 4545-4547 DT denotes an
T1039 4566-4575 NN denotes phenotype
T1040 4548-4557 JJ denotes exclusive
T1041 4558-4565 NN denotes disease
T1042 4576-4577 -LRB- denotes (
T1043 4583-4591 NN denotes XPDR722W
T1044 4577-4581 FW denotes e.g.
T1045 4581-4583 , denotes ,
T1046 4592-4596 IN denotes with
T1047 4597-4600 NN denotes TTD
T1048 4601-4604 CC denotes and
T1049 4605-4613 NN denotes XPDR683W
T1050 4614-4618 IN denotes with
T1051 4619-4621 NN denotes XP
T1052 4621-4622 -RRB- denotes )
T1053 4623-4626 CC denotes and
T1054 4627-4630 VBP denotes are
T1055 4636-4642 VBN denotes viewed
T1056 4631-4635 RB denotes thus
T1057 4643-4645 IN denotes as
T1058 4646-4655 JJ denotes causative
T1059 4656-4658 IN denotes of
T1060 4659-4662 DT denotes the
T1061 4677-4686 NNS denotes syndromes
T1062 4663-4676 VBG denotes corresponding
T1063 4686-4687 . denotes .
T1064 4687-4786 sentence denotes Alleles not associated exclusively with one disorder are considered “likely null” alleles [19,20].
T1065 4688-4695 NNS denotes Alleles
T1066 4745-4755 VBN denotes considered
T1067 4696-4699 RB denotes not
T1068 4700-4710 VBN denotes associated
T1069 4711-4722 RB denotes exclusively
T1070 4723-4727 IN denotes with
T1071 4728-4731 CD denotes one
T1072 4732-4740 NN denotes disorder
T1073 4741-4744 VBP denotes are
T1074 4756-4757 `` denotes “
T1075 4770-4777 NNS denotes alleles
T1076 4757-4763 RB denotes likely
T1077 4764-4768 JJ denotes null
T1078 4768-4769 '' denotes ”
T1079 4778-4779 -LRB- denotes [
T1080 4782-4784 CD denotes 20
T1081 4779-4781 CD denotes 19
T1082 4781-4782 , denotes ,
T1083 4784-4785 -RRB- denotes ]
T1084 4785-4786 . denotes .
T1085 4786-5006 sentence denotes Some of these alleles fail to support viability in a haploid Schizosaccharomyces pombe yeast strain with a null mutation in the XPD homologue rad15 and are thus considered devoid of significant biological activity [19].
T1086 4787-4791 DT denotes Some
T1087 4809-4813 VBP denotes fail
T1088 4792-4794 IN denotes of
T1089 4795-4800 DT denotes these
T1090 4801-4808 NNS denotes alleles
T1091 4814-4816 TO denotes to
T1092 4817-4824 VB denotes support
T1093 4825-4834 NN denotes viability
T1094 4835-4837 IN denotes in
T1095 4838-4839 DT denotes a
T1096 4880-4886 NN denotes strain
T1097 4840-4847 JJ denotes haploid
T1098 4848-4867 NNP denotes Schizosaccharomyces
T1099 4868-4873 NNP denotes pombe
T1100 4874-4879 NN denotes yeast
T1101 4887-4891 IN denotes with
T1102 4892-4893 DT denotes a
T1103 4899-4907 NN denotes mutation
T1104 4894-4898 JJ denotes null
T1105 4908-4910 IN denotes in
T1106 4911-4914 DT denotes the
T1107 4929-4934 NN denotes rad15
T1108 4915-4918 NN denotes XPD
T1109 4919-4928 NN denotes homologue
T1110 4935-4938 CC denotes and
T1111 4939-4942 VBP denotes are
T1112 4948-4958 VBN denotes considered
T1113 4943-4947 RB denotes thus
T1114 4959-4965 JJ denotes devoid
T1115 4966-4968 IN denotes of
T1116 4969-4980 JJ denotes significant
T1117 4992-5000 NN denotes activity
T1118 4981-4991 JJ denotes biological
T1119 5001-5002 -LRB- denotes [
T1120 5002-5004 CD denotes 19
T1121 5004-5005 -RRB- denotes ]
T1122 5005-5006 . denotes .
T1123 5006-5144 sentence denotes This classification of alleles as either causative or null currently defines what we refer to as a “monoallelic” paradigm of XPD disease.
T1124 5007-5011 DT denotes This
T1125 5012-5026 NN denotes classification
T1126 5076-5083 VBZ denotes defines
T1127 5027-5029 IN denotes of
T1128 5030-5037 NNS denotes alleles
T1129 5038-5040 IN denotes as
T1130 5041-5047 CC denotes either
T1131 5048-5057 JJ denotes causative
T1132 5058-5060 CC denotes or
T1133 5061-5065 JJ denotes null
T1134 5066-5075 RB denotes currently
T1135 5084-5088 WP denotes what
T1136 5092-5097 VBP denotes refer
T1137 5089-5091 PRP denotes we
T1138 5098-5100 IN denotes to
T1139 5101-5103 IN denotes as
T1140 5104-5105 DT denotes a
T1141 5120-5128 NN denotes paradigm
T1142 5106-5107 `` denotes “
T1143 5107-5118 JJ denotes monoallelic
T1144 5118-5119 '' denotes ”
T1145 5129-5131 IN denotes of
T1146 5132-5135 NN denotes XPD
T1147 5136-5143 NN denotes disease
T1148 5143-5144 . denotes .
T1149 5144-5425 sentence denotes However, the identification in recent years of XP complementation group D patients with atypical disease presentation, including symptoms of both XP and TTD [8], casts doubt on the ability of such a monoallelic paradigm to explain clinical heterogeneity in compound heterozygotes.
T1150 5145-5152 RB denotes However
T1151 5307-5312 VBZ denotes casts
T1152 5152-5154 , denotes ,
T1153 5154-5157 DT denotes the
T1154 5158-5172 NN denotes identification
T1155 5173-5175 IN denotes in
T1156 5176-5182 JJ denotes recent
T1157 5183-5188 NNS denotes years
T1158 5189-5191 IN denotes of
T1159 5192-5194 NN denotes XP
T1160 5219-5227 NNS denotes patients
T1161 5195-5210 NN denotes complementation
T1162 5211-5216 NN denotes group
T1163 5217-5218 NN denotes D
T1164 5228-5232 IN denotes with
T1165 5233-5241 JJ denotes atypical
T1166 5250-5262 NN denotes presentation
T1167 5242-5249 NN denotes disease
T1168 5262-5264 , denotes ,
T1169 5264-5273 VBG denotes including
T1170 5274-5282 NNS denotes symptoms
T1171 5283-5285 IN denotes of
T1172 5286-5290 CC denotes both
T1173 5291-5293 NN denotes XP
T1174 5294-5297 CC denotes and
T1175 5298-5301 NN denotes TTD
T1176 5302-5303 -LRB- denotes [
T1177 5303-5304 CD denotes 8
T1178 5304-5305 -RRB- denotes ]
T1179 5305-5307 , denotes ,
T1180 5313-5318 NN denotes doubt
T1181 5319-5321 IN denotes on
T1182 5322-5325 DT denotes the
T1183 5326-5333 NN denotes ability
T1184 5334-5336 IN denotes of
T1185 5337-5341 JJ denotes such
T1186 5356-5364 NN denotes paradigm
T1187 5342-5343 DT denotes a
T1188 5344-5355 JJ denotes monoallelic
T1189 5365-5367 TO denotes to
T1190 5368-5375 VB denotes explain
T1191 5376-5384 JJ denotes clinical
T1192 5385-5398 NN denotes heterogeneity
T1193 5399-5401 IN denotes in
T1194 5402-5410 NN denotes compound
T1195 5411-5424 NNS denotes heterozygotes
T1196 5424-5425 . denotes .
T1197 5425-5524 sentence denotes Previously, we generated a TTD mouse model (XPDR722W) that phenocopies the human syndrome [15,21].
T1198 5426-5436 RB denotes Previously
T1199 5441-5450 VBD denotes generated
T1200 5436-5438 , denotes ,
T1201 5438-5440 PRP denotes we
T1202 5451-5452 DT denotes a
T1203 5463-5468 NN denotes model
T1204 5453-5456 NN denotes TTD
T1205 5457-5462 NN denotes mouse
T1206 5469-5470 -LRB- denotes (
T1207 5470-5478 NN denotes XPDR722W
T1208 5478-5479 -RRB- denotes )
T1209 5480-5484 WDT denotes that
T1210 5485-5496 VBZ denotes phenocopies
T1211 5497-5500 DT denotes the
T1212 5507-5515 NN denotes syndrome
T1213 5501-5506 JJ denotes human
T1214 5516-5517 -LRB- denotes [
T1215 5520-5522 CD denotes 21
T1216 5517-5519 CD denotes 15
T1217 5519-5520 , denotes ,
T1218 5522-5523 -RRB- denotes ]
T1219 5523-5524 . denotes .
T1220 5524-5815 sentence denotes Here we report the generation of additional mutant Xpd alleles that fail to support viability on their own but nevertheless ameliorate TTD-associated premature segmental ageing, cutaneous features, cellular DNA repair capacity, and UV survival when present in a compound heterozygote state.
T1221 5525-5529 RB denotes Here
T1222 5533-5539 VBP denotes report
T1223 5530-5532 PRP denotes we
T1224 5540-5543 DT denotes the
T1225 5544-5554 NN denotes generation
T1226 5555-5557 IN denotes of
T1227 5558-5568 JJ denotes additional
T1228 5580-5587 NNS denotes alleles
T1229 5569-5575 JJ denotes mutant
T1230 5576-5579 NN denotes Xpd
T1231 5588-5592 WDT denotes that
T1232 5593-5597 VBP denotes fail
T1233 5598-5600 TO denotes to
T1234 5601-5608 VB denotes support
T1235 5609-5618 NN denotes viability
T1236 5619-5621 IN denotes on
T1237 5622-5627 PRP$ denotes their
T1238 5628-5631 NN denotes own
T1239 5632-5635 CC denotes but
T1240 5636-5648 RB denotes nevertheless
T1241 5649-5659 VBP denotes ameliorate
T1242 5660-5663 NN denotes TTD
T1243 5664-5674 VBN denotes associated
T1244 5663-5664 HYPH denotes -
T1245 5695-5701 NN denotes ageing
T1246 5675-5684 JJ denotes premature
T1247 5685-5694 JJ denotes segmental
T1248 5701-5703 , denotes ,
T1249 5703-5712 JJ denotes cutaneous
T1250 5713-5721 NNS denotes features
T1251 5721-5723 , denotes ,
T1252 5723-5731 JJ denotes cellular
T1253 5743-5751 NN denotes capacity
T1254 5732-5735 NN denotes DNA
T1255 5736-5742 NN denotes repair
T1256 5751-5753 , denotes ,
T1257 5753-5756 CC denotes and
T1258 5757-5759 NN denotes UV
T1259 5760-5768 NN denotes survival
T1260 5769-5773 WRB denotes when
T1261 5774-5781 JJ denotes present
T1262 5782-5784 IN denotes in
T1263 5785-5786 DT denotes a
T1264 5809-5814 NN denotes state
T1265 5787-5795 JJ denotes compound
T1266 5796-5808 NN denotes heterozygote
T1267 5814-5815 . denotes .
T1400 5826-5836 NN denotes Generation
T1401 5837-5839 IN denotes of
T1402 5840-5843 NN denotes Xpd
T1403 5853-5866 NNS denotes Heterozygotes
T1404 5844-5852 NN denotes Compound
T1405 5866-6019 sentence denotes We generated an Xpd knock-in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A–1C).
T1406 5867-5869 PRP denotes We
T1407 5870-5879 VBD denotes generated
T1408 5880-5882 DT denotes an
T1409 5896-5902 NN denotes allele
T1410 5883-5886 NN denotes Xpd
T1411 5887-5892 VB denotes knock
T1412 5892-5893 HYPH denotes -
T1413 5893-5895 RP denotes in
T1414 5903-5907 IN denotes with
T1415 5908-5909 DT denotes a
T1416 5916-5924 NN denotes mutation
T1417 5910-5915 NN denotes point
T1418 5925-5933 VBG denotes encoding
T1419 5934-5935 DT denotes a
T1420 5954-5960 NN denotes change
T1421 5936-5942 JJ denotes single
T1422 5943-5948 NN denotes amino
T1423 5949-5953 NN denotes acid
T1424 5961-5962 -LRB- denotes (
T1425 5962-5970 NN denotes XPDG602D
T1426 5970-5971 -RRB- denotes )
T1427 5972-5977 VBN denotes found
T1428 5978-5980 IN denotes in
T1429 5981-5984 DT denotes the
T1430 5990-5997 NN denotes patient
T1431 5985-5989 NN denotes XPCS
T1432 5998-6003 NN denotes XPCS2
T1433 6004-6005 -LRB- denotes (
T1434 6012-6014 NN denotes 1A
T1435 6005-6011 NN denotes Figure
T1436 6014-6015 SYM denotes –
T1437 6015-6017 NN denotes 1C
T1438 6017-6018 -RRB- denotes )
T1439 6018-6019 . denotes .
T1440 6019-6311 sentence denotes mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).
T1441 6020-6024 NN denotes mRNA
T1442 6025-6035 NN denotes expression
T1443 6070-6078 VBN denotes detected
T1444 6036-6040 IN denotes from
T1445 6041-6044 DT denotes the
T1446 6054-6060 NN denotes allele
T1447 6045-6053 VBN denotes targeted
T1448 6061-6066 MD denotes could
T1449 6067-6069 VB denotes be
T1450 6079-6081 IN denotes in
T1451 6082-6091 JJ denotes embryonic
T1452 6097-6102 NNS denotes cells
T1453 6092-6096 NN denotes stem
T1454 6103-6105 IN denotes by
T1455 6106-6108 NN denotes RT
T1456 6109-6112 NN denotes PCR
T1457 6108-6109 HYPH denotes -
T1458 6113-6114 -LRB- denotes (
T1459 6121-6123 NN denotes 1D
T1460 6114-6120 NN denotes Figure
T1461 6123-6124 -RRB- denotes )
T1462 6124-6126 , denotes ,
T1463 6126-6134 IN denotes although
T1464 6150-6157 VBN denotes reduced
T1465 6135-6145 NN denotes expression
T1466 6146-6149 VBD denotes was
T1467 6158-6171 RB denotes approximately
T1468 6172-6173 CD denotes 5
T1469 6173-6174 HYPH denotes -
T1470 6174-6178 RB denotes fold
T1471 6179-6187 JJ denotes relative
T1472 6188-6190 IN denotes to
T1473 6191-6193 NN denotes wt
T1474 6210-6216 NNS denotes levels
T1475 6194-6198 NN denotes mRNA
T1476 6199-6209 NN denotes transcript
T1477 6217-6219 IN denotes as
T1478 6220-6230 VBN denotes determined
T1479 6231-6233 IN denotes by
T1480 6234-6242 NNP denotes Northern
T1481 6243-6251 VBG denotes blotting
T1482 6252-6254 IN denotes of
T1483 6255-6258 NN denotes RNA
T1484 6259-6263 IN denotes from
T1485 6264-6267 DT denotes the
T1486 6268-6274 NN denotes testis
T1487 6275-6277 IN denotes of
T1488 6278-6290 JJ denotes heterozygous
T1489 6291-6298 NNS denotes animals
T1490 6299-6300 -LRB- denotes (
T1491 6307-6309 NN denotes 1E
T1492 6300-6306 NN denotes Figure
T1493 6309-6310 -RRB- denotes )
T1494 6310-6311 . denotes .
T1495 6311-6495 sentence denotes Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state.
T1496 6312-6319 IN denotes Because
T1497 6334-6337 VBD denotes was
T1498 6320-6327 NN denotes patient
T1499 6328-6333 NN denotes XPCS2
T1500 6449-6457 VBN denotes expected
T1501 6338-6339 DT denotes a
T1502 6340-6350 NN denotes hemizygote
T1503 6351-6355 IN denotes with
T1504 6356-6362 JJ denotes mutant
T1505 6367-6374 NN denotes protein
T1506 6363-6366 NN denotes XPD
T1507 6375-6376 -LRB- denotes (
T1508 6376-6384 NN denotes XPDG602D
T1509 6384-6385 -RRB- denotes )
T1510 6386-6395 VBN denotes expressed
T1511 6396-6400 IN denotes from
T1512 6401-6402 DT denotes a
T1513 6410-6416 NN denotes allele
T1514 6403-6409 JJ denotes single
T1515 6416-6418 , denotes ,
T1516 6418-6421 DT denotes the
T1517 6436-6444 NN denotes mutation
T1518 6422-6435 VBG denotes corresponding
T1519 6445-6448 VBD denotes was
T1520 6458-6460 TO denotes to
T1521 6461-6463 VB denotes be
T1522 6464-6470 JJ denotes viable
T1523 6471-6473 IN denotes in
T1524 6474-6477 DT denotes the
T1525 6489-6494 NN denotes state
T1526 6478-6488 JJ denotes homozygous
T1527 6494-6495 . denotes .
T1528 6495-6632 sentence denotes However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1).
T1529 6496-6503 RB denotes However
T1530 6537-6545 VBN denotes observed
T1531 6503-6505 , denotes ,
T1532 6505-6515 JJ denotes homozygous
T1533 6523-6527 NNS denotes mice
T1534 6516-6522 JJ denotes mutant
T1535 6528-6532 VBD denotes were
T1536 6533-6536 RB denotes not
T1537 6545-6547 , denotes ,
T1538 6547-6554 CC denotes neither
T1539 6555-6562 IN denotes amongst
T1540 6563-6567 JJ denotes live
T1541 6568-6574 NNS denotes births
T1542 6575-6578 CC denotes nor
T1543 6579-6588 JJ denotes embryonic
T1544 6589-6592 NN denotes day
T1545 6614-6621 NNS denotes embryos
T1546 6593-6597 CD denotes 13.5
T1547 6598-6599 -LRB- denotes (
T1548 6599-6604 NN denotes E13.5
T1549 6604-6605 -RRB- denotes )
T1550 6606-6608 CC denotes or
T1551 6609-6613 NN denotes E3.5
T1552 6622-6623 -LRB- denotes (
T1553 6623-6628 NN denotes Table
T1554 6629-6630 CD denotes 1
T1555 6630-6631 -RRB- denotes )
T1556 6631-6632 . denotes .
T1557 6632-6727 sentence denotes The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS).
T1558 6633-6636 DT denotes The
T1559 6671-6677 NN denotes allele
T1560 6637-6650 VBG denotes corresponding
T1561 6651-6662 JJ denotes hypomorphic
T1562 6662-6664 , denotes ,
T1563 6664-6670 JJ denotes mutant
T1564 6687-6697 VBN denotes designated
T1565 6678-6681 VBD denotes was
T1566 6682-6686 RB denotes thus
T1567 6698-6700 IN denotes as
T1568 6701-6711 JJ denotes homozygous
T1569 6712-6718 JJ denotes lethal
T1570 6719-6720 -LRB- denotes (
T1571 6720-6725 NN denotes †XPCS
T1572 6725-6726 -RRB- denotes )
T1573 6726-6727 . denotes .
T1574 6727-6917 sentence denotes Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.
T1575 6728-6738 JJ denotes Homozygous
T1576 6739-6748 NN denotes lethality
T1577 6768-6770 VBZ denotes is
T1578 6749-6751 IN denotes of
T1579 6752-6755 DT denotes the
T1580 6761-6767 NN denotes allele
T1581 6756-6760 NN denotes XPCS
T1582 6771-6777 RB denotes likely
T1583 6778-6781 IN denotes due
T1584 6782-6784 IN denotes to
T1585 6785-6792 VBN denotes reduced
T1586 6793-6799 NNS denotes levels
T1587 6800-6802 IN denotes of
T1588 6803-6813 NN denotes expression
T1589 6814-6816 IN denotes of
T1590 6817-6821 DT denotes this
T1591 6832-6839 NN denotes protein
T1592 6822-6831 JJ denotes essential
T1593 6840-6842 IN denotes as
T1594 6843-6844 DT denotes a
T1595 6845-6851 NN denotes result
T1596 6852-6854 IN denotes of
T1597 6855-6859 NN denotes gene
T1598 6860-6869 NN denotes targeting
T1599 6870-6871 -LRB- denotes (
T1600 6878-6880 NN denotes 1A
T1601 6871-6877 NN denotes Figure
T1602 6880-6881 -RRB- denotes )
T1603 6882-6888 JJ denotes rather
T1604 6889-6893 IN denotes than
T1605 6894-6896 IN denotes to
T1606 6897-6900 DT denotes the
T1607 6901-6909 NN denotes mutation
T1608 6910-6916 PRP denotes itself
T1609 6916-6917 . denotes .
T1610 6917-7029 sentence denotes Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22].
T1611 6918-6921 NN denotes Xpd
T1612 6922-6930 NN denotes ablation
T1613 6944-6946 VBZ denotes is
T1614 6931-6932 -LRB- denotes (
T1615 6939-6941 NN denotes KO
T1616 6932-6937 NN denotes XpdKO
T1617 6938-6939 HYPH denotes /
T1618 6942-6943 -RRB- denotes )
T1619 6947-6956 RB denotes similarly
T1620 6957-6969 JJ denotes incompatible
T1621 6970-6974 IN denotes with
T1622 6975-6979 NN denotes life
T1623 6980-6986 IN denotes beyond
T1624 6987-6990 DT denotes the
T1625 7000-7006 NNS denotes stages
T1626 6991-6999 JJS denotes earliest
T1627 7007-7009 IN denotes of
T1628 7010-7023 NN denotes embryogenesis
T1629 7024-7025 -LRB- denotes [
T1630 7025-7027 CD denotes 22
T1631 7027-7028 -RRB- denotes ]
T1632 7028-7029 . denotes .
T1633 7029-7316 sentence denotes Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data).
T1634 7030-7040 JJ denotes Consistent
T1635 7183-7186 VBD denotes was
T1636 7041-7045 IN denotes with
T1637 7046-7050 DT denotes this
T1638 7051-7065 NN denotes interpretation
T1639 7065-7067 , denotes ,
T1640 7067-7068 DT denotes a
T1641 7092-7100 NN denotes mutation
T1642 7069-7078 JJ denotes different
T1643 7079-7087 VBN denotes targeted
T1644 7088-7091 NN denotes Xpd
T1645 7101-7109 VBG denotes encoding
T1646 7110-7118 NN denotes XPDR683W
T1647 7118-7120 , denotes ,
T1648 7120-7125 WDT denotes which
T1649 7129-7139 VBN denotes associated
T1650 7126-7128 VBZ denotes is
T1651 7140-7144 IN denotes with
T1652 7145-7147 NN denotes XP
T1653 7148-7150 IN denotes in
T1654 7151-7154 DT denotes the
T1655 7166-7171 NN denotes state
T1656 7155-7165 JJ denotes homozygous
T1657 7172-7174 IN denotes in
T1658 7175-7181 NNS denotes humans
T1659 7181-7183 , denotes ,
T1660 7187-7196 RB denotes similarly
T1661 7197-7211 JJ denotes underexpressed
T1662 7212-7215 CC denotes and
T1663 7216-7222 JJ denotes lethal
T1664 7223-7225 IN denotes in
T1665 7226-7229 DT denotes the
T1666 7241-7246 NN denotes state
T1667 7230-7240 JJ denotes homozygous
T1668 7247-7248 -LRB- denotes (
T1669 7248-7258 VBN denotes designated
T1670 7259-7261 IN denotes as
T1671 7262-7265 NN denotes †XP
T1672 7266-7272 NN denotes allele
T1673 7272-7273 -RRB- denotes )
T1674 7274-7275 -LRB- denotes (
T1675 7282-7284 NN denotes 1A
T1676 7275-7281 NN denotes Figure
T1677 7284-7285 SYM denotes –
T1678 7285-7287 NN denotes 1C
T1679 7287-7288 : denotes ;
T1680 7289-7294 NN denotes Table
T1681 7295-7296 CD denotes 1
T1682 7296-7297 : denotes ;
T1683 7298-7309 JJ denotes unpublished
T1684 7310-7314 NNS denotes data
T1685 7314-7315 -RRB- denotes )
T1686 7315-7316 . denotes .
T1687 7316-7535 sentence denotes Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23].
T1688 7317-7321 RB denotes Also
T1689 7421-7429 VBD denotes resulted
T1690 7321-7323 , denotes ,
T1691 7323-7324 DT denotes a
T1692 7345-7353 NN denotes approach
T1693 7325-7334 JJ denotes different
T1694 7335-7344 NN denotes targeting
T1695 7354-7361 VBG denotes leading
T1696 7362-7364 IN denotes to
T1697 7365-7368 DT denotes the
T1698 7369-7372 NN denotes use
T1699 7373-7375 IN denotes of
T1700 7376-7379 DT denotes the
T1701 7389-7392 NN denotes UTR
T1702 7380-7386 JJ denotes native
T1703 7387-7388 CD denotes 3
T1704 7388-7389 SYM denotes ′
T1705 7393-7396 CC denotes and
T1706 7397-7404 NN denotes removal
T1707 7405-7407 IN denotes of
T1708 7408-7411 DT denotes the
T1709 7416-7420 NN denotes gene
T1710 7412-7415 NN denotes neo
T1711 7430-7432 IN denotes in
T1712 7433-7446 NN denotes normalisation
T1713 7447-7449 IN denotes of
T1714 7450-7457 NN denotes XpdXPCS
T1715 7463-7469 NNS denotes levels
T1716 7458-7462 NN denotes mRNA
T1717 7470-7473 CC denotes and
T1718 7474-7480 JJ denotes viable
T1719 7522-7529 NNS denotes animals
T1720 7481-7491 JJ denotes homozygous
T1721 7492-7499 NN denotes XpdXPCS
T1722 7500-7504 NN denotes XPCS
T1723 7499-7500 HYPH denotes /
T1724 7505-7506 -LRB- denotes (
T1725 7515-7520 NN denotes G602D
T1726 7506-7514 NN denotes XPDG602D
T1727 7514-7515 HYPH denotes /
T1728 7520-7521 -RRB- denotes )
T1729 7530-7531 -LRB- denotes [
T1730 7531-7533 CD denotes 23
T1731 7533-7534 -RRB- denotes ]
T1732 7534-7535 . denotes .
T1954 9845-9846 `` denotes “
T1955 9852-9858 NN denotes Allele
T1956 9846-9850 JJ denotes Null
T1957 9850-9851 '' denotes ”
T1958 9863-9872 VB denotes Alleviate
T1959 9859-9862 MD denotes Can
T1960 9873-9886 JJ denotes Developmental
T1961 9887-9892 NN denotes Delay
T1962 9892-9894 , denotes ,
T1963 9894-9898 NN denotes Skin
T1964 9909-9917 NNS denotes Features
T1965 9898-9900 , denotes ,
T1966 9900-9903 CC denotes and
T1967 9904-9908 NN denotes Hair
T1968 9918-9920 IN denotes of
T1969 9921-9924 NN denotes TTD
T1970 9924-10146 sentence denotes To test the potential of a homozygous lethal “null” allele to nevertheless contribute to organismal phenotype, we combined an Xpd†XPCS allele with a viable XpdTTD allele by crossing the corresponding heterozygous animals.
T1971 9925-9927 TO denotes To
T1972 9928-9932 VB denotes test
T1973 10039-10047 VBD denotes combined
T1974 9933-9936 DT denotes the
T1975 9937-9946 NN denotes potential
T1976 9947-9949 IN denotes of
T1977 9950-9951 DT denotes a
T1978 9977-9983 NN denotes allele
T1979 9952-9962 JJ denotes homozygous
T1980 9963-9969 JJ denotes lethal
T1981 9970-9971 `` denotes “
T1982 9971-9975 JJ denotes null
T1983 9975-9976 '' denotes ”
T1984 9984-9986 TO denotes to
T1985 10000-10010 VB denotes contribute
T1986 9987-9999 RB denotes nevertheless
T1987 10011-10013 IN denotes to
T1988 10014-10024 JJ denotes organismal
T1989 10025-10034 NN denotes phenotype
T1990 10034-10036 , denotes ,
T1991 10036-10038 PRP denotes we
T1992 10048-10050 DT denotes an
T1993 10060-10066 NN denotes allele
T1994 10051-10059 NN denotes Xpd†XPCS
T1995 10067-10071 IN denotes with
T1996 10072-10073 DT denotes a
T1997 10088-10094 NN denotes allele
T1998 10074-10080 JJ denotes viable
T1999 10081-10087 NN denotes XpdTTD
T2000 10095-10097 IN denotes by
T2001 10098-10106 VBG denotes crossing
T2002 10107-10110 DT denotes the
T2003 10138-10145 NNS denotes animals
T2004 10111-10124 VBG denotes corresponding
T2005 10125-10137 JJ denotes heterozygous
T2006 10145-10146 . denotes .
T2007 10146-10317 sentence denotes Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies.
T2008 10147-10154 JJ denotes Similar
T2009 10274-10278 VBN denotes born
T2010 10155-10157 IN denotes to
T2011 10158-10168 JJ denotes hemizygous
T2012 10173-10177 NNS denotes mice
T2013 10169-10172 NN denotes TTD
T2014 10178-10186 VBG denotes carrying
T2015 10187-10190 CD denotes one
T2016 10209-10215 NN denotes allele
T2017 10191-10195 JJ denotes true
T2018 10196-10199 NN denotes Xpd
T2019 10200-10208 NN denotes knockout
T2020 10216-10217 -LRB- denotes (
T2021 10224-10226 NN denotes KO
T2022 10217-10223 NN denotes XpdTTD
T2023 10223-10224 HYPH denotes /
T2024 10226-10227 -RRB- denotes )
T2025 10227-10229 , denotes ,
T2026 10229-10237 NN denotes compound
T2027 10264-10268 NNS denotes mice
T2028 10238-10250 JJ denotes heterozygous
T2029 10251-10257 NN denotes XpdTTD
T2030 10258-10263 NN denotes †XPCS
T2031 10257-10258 HYPH denotes /
T2032 10269-10273 VBD denotes were
T2033 10279-10281 IN denotes at
T2034 10282-10285 DT denotes the
T2035 10305-10316 NNS denotes frequencies
T2036 10286-10294 VBN denotes expected
T2037 10295-10304 JJ denotes Mendelian
T2038 10316-10317 . denotes .
T2039 10317-10513 sentence denotes Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E).
T2040 10318-10328 NN denotes Expression
T2041 10363-10370 VBN denotes reduced
T2042 10329-10333 IN denotes from
T2043 10334-10337 DT denotes the
T2044 10347-10353 NN denotes allele
T2045 10338-10346 NN denotes Xpd†XPCS
T2046 10354-10357 VBD denotes was
T2047 10358-10362 RB denotes also
T2048 10371-10373 IN denotes in
T2049 10374-10377 DT denotes the
T2050 10378-10384 NN denotes testis
T2051 10385-10387 IN denotes of
T2052 10388-10396 NN denotes compound
T2053 10410-10417 NNS denotes animals
T2054 10397-10409 JJ denotes heterozygous
T2055 10417-10419 , denotes ,
T2056 10419-10426 IN denotes whereas
T2057 10465-10474 VBN denotes increased
T2058 10427-10437 NN denotes expression
T2059 10438-10442 IN denotes from
T2060 10443-10446 DT denotes the
T2061 10454-10460 NN denotes allele
T2062 10447-10453 NN denotes XpdTTD
T2063 10461-10464 VBD denotes was
T2064 10475-10483 JJ denotes relative
T2065 10484-10486 IN denotes to
T2066 10487-10489 NN denotes wt
T2067 10490-10492 IN denotes by
T2068 10493-10494 SYM denotes ~
T2069 10494-10500 RB denotes 5-fold
T2070 10501-10502 -LRB- denotes (
T2071 10509-10511 NN denotes 1E
T2072 10502-10508 NN denotes Figure
T2073 10511-10512 -RRB- denotes )
T2074 10512-10513 . denotes .
T2075 10513-10766 sentence denotes Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles.
T2076 10514-10521 IN denotes Because
T2077 10679-10683 VBD denotes were
T2078 10522-10524 IN denotes of
T2079 10525-10526 DT denotes a
T2080 10527-10531 NN denotes lack
T2081 10532-10534 IN denotes of
T2082 10535-10544 JJ denotes available
T2083 10545-10555 NNS denotes antibodies
T2084 10556-10559 CC denotes and
T2085 10560-10563 DT denotes the
T2086 10564-10573 NN denotes inability
T2087 10574-10576 TO denotes to
T2088 10577-10588 VB denotes distinguish
T2089 10589-10596 IN denotes amongst
T2090 10597-10604 JJ denotes various
T2091 10612-10617 NNS denotes forms
T2092 10605-10611 JJ denotes mutant
T2093 10618-10620 IN denotes of
T2094 10621-10624 NN denotes XPD
T2095 10625-10634 VBG denotes differing
T2096 10635-10639 RB denotes only
T2097 10640-10642 IN denotes by
T2098 10643-10649 JJ denotes single
T2099 10661-10674 NNS denotes substitutions
T2100 10650-10655 NN denotes amino
T2101 10656-10660 NN denotes acid
T2102 10674-10676 , denotes ,
T2103 10676-10678 PRP denotes we
T2104 10684-10690 JJ denotes unable
T2105 10691-10693 TO denotes to
T2106 10694-10703 VB denotes ascertain
T2107 10704-10707 DT denotes the
T2108 10717-10723 NN denotes amount
T2109 10708-10716 JJ denotes relative
T2110 10724-10726 IN denotes of
T2111 10727-10730 NN denotes XPD
T2112 10731-10738 NN denotes protein
T2113 10739-10743 IN denotes from
T2114 10744-10747 DT denotes the
T2115 10758-10765 NNS denotes alleles
T2116 10748-10757 JJ denotes different
T2117 10765-10766 . denotes .
T2118 10766-11073 sentence denotes Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C).
T2119 10767-10774 IN denotes Despite
T2120 10848-10859 VBD denotes ameliorated
T2121 10775-10782 VBN denotes reduced
T2122 10783-10789 NNS denotes levels
T2123 10790-10792 IN denotes of
T2124 10793-10797 NN denotes mRNA
T2125 10798-10808 NN denotes expression
T2126 10808-10810 , denotes ,
T2127 10810-10813 DT denotes the
T2128 10841-10847 NN denotes allele
T2129 10814-10824 JJ denotes homozygous
T2130 10825-10831 JJ denotes lethal
T2131 10832-10840 NN denotes Xpd†XPCS
T2132 10860-10868 JJ denotes multiple
T2133 10895-10903 NNS denotes symptoms
T2134 10869-10875 NN denotes XpdTTD
T2135 10876-10886 JJ denotes associated
T2136 10875-10876 HYPH denotes -
T2137 10887-10894 NN denotes disease
T2138 10904-10906 IN denotes in
T2139 10907-10915 JJ denotes compound
T2140 10942-10949 NNS denotes animals
T2141 10916-10928 JJ denotes heterozygous
T2142 10929-10935 NN denotes XpdTTD
T2143 10936-10941 NN denotes †XPCS
T2144 10935-10936 HYPH denotes /
T2145 10950-10959 VBG denotes including
T2146 10960-10963 DT denotes the
T2147 10981-10985 NN denotes hair
T2148 10964-10972 NN denotes hallmark
T2149 10973-10980 JJ denotes brittle
T2150 10986-10989 CC denotes and
T2151 10990-10999 JJ denotes cutaneous
T2152 11000-11008 NNS denotes features
T2153 11009-11014 RB denotes fully
T2154 11015-11024 JJ denotes penetrant
T2155 11025-11027 IN denotes in
T2156 11028-11032 AFX denotes homo
T2157 11038-11048 JJ denotes hemizygous
T2158 11032-11033 HYPH denotes -
T2159 11034-11037 CC denotes and
T2160 11053-11057 NNS denotes mice
T2161 11049-11052 NN denotes TTD
T2162 11058-11059 -LRB- denotes (
T2163 11066-11068 NN denotes 2A
T2164 11059-11065 NN denotes Figure
T2165 11068-11069 SYM denotes –
T2166 11069-11071 NN denotes 2C
T2167 11071-11072 -RRB- denotes )
T2168 11072-11073 . denotes .
T2169 11073-11397 sentence denotes In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A).
T2170 11074-11076 IN denotes In
T2171 11298-11307 VBD denotes displayed
T2172 11077-11083 JJ denotes marked
T2173 11084-11092 NN denotes contrast
T2174 11093-11095 IN denotes to
T2175 11096-11102 NN denotes XpdTTD
T2176 11103-11106 NN denotes TTD
T2177 11102-11103 HYPH denotes /
T2178 11123-11127 NNS denotes mice
T2179 11107-11108 -LRB- denotes (
T2180 11108-11111 CC denotes and
T2181 11112-11118 NN denotes XpdTTD
T2182 11119-11121 NN denotes KO
T2183 11118-11119 HYPH denotes /
T2184 11121-11122 -RRB- denotes )
T2185 11127-11129 , denotes ,
T2186 11129-11134 WDT denotes which
T2187 11135-11142 VBP denotes display
T2188 11143-11151 JJ denotes complete
T2189 11157-11161 NN denotes loss
T2190 11152-11156 NN denotes hair
T2191 11162-11164 IN denotes in
T2192 11165-11168 DT denotes the
T2193 11180-11185 NN denotes cycle
T2194 11169-11174 JJ denotes first
T2195 11175-11179 NN denotes hair
T2196 11186-11189 CC denotes and
T2197 11190-11197 JJ denotes partial
T2198 11203-11207 NN denotes loss
T2199 11198-11202 NN denotes hair
T2200 11208-11210 IN denotes in
T2201 11211-11221 JJ denotes subsequent
T2202 11222-11228 NNS denotes cycles
T2203 11229-11239 IN denotes throughout
T2204 11240-11245 PRP$ denotes their
T2205 11246-11251 NNS denotes lives
T2206 11252-11253 -LRB- denotes [
T2207 11253-11255 CD denotes 21
T2208 11255-11256 -RRB- denotes ]
T2209 11256-11258 , denotes ,
T2210 11258-11266 NN denotes compound
T2211 11293-11297 NNS denotes mice
T2212 11267-11279 JJ denotes heterozygous
T2213 11280-11292 NN denotes XpdTTD/†XPCS
T2214 11308-11312 DT denotes some
T2215 11318-11322 NN denotes loss
T2216 11313-11317 NN denotes hair
T2217 11323-11327 RB denotes only
T2218 11328-11334 IN denotes during
T2219 11335-11338 DT denotes the
T2220 11350-11355 NN denotes cycle
T2221 11339-11344 JJ denotes first
T2222 11345-11349 NN denotes hair
T2223 11356-11359 CC denotes and
T2224 11360-11364 RB denotes only
T2225 11365-11372 RB denotes locally
T2226 11373-11375 IN denotes at
T2227 11376-11379 DT denotes the
T2228 11380-11384 NN denotes back
T2229 11385-11386 -LRB- denotes (
T2230 11393-11395 NN denotes 2A
T2231 11386-11392 NN denotes Figure
T2232 11395-11396 -RRB- denotes )
T2233 11396-11397 . denotes .
T2234 11397-11591 sentence denotes Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data).
T2235 11398-11406 NN denotes Scanning
T2236 11416-11426 NN denotes microscope
T2237 11407-11415 NN denotes electron
T2238 11427-11435 NN denotes analysis
T2239 11457-11465 VBD denotes revealed
T2240 11436-11438 IN denotes of
T2241 11439-11445 NN denotes XpdTTD
T2242 11446-11451 NN denotes †XPCS
T2243 11445-11446 HYPH denotes /
T2244 11452-11456 NN denotes hair
T2245 11466-11468 DT denotes an
T2246 11483-11493 NN denotes appearance
T2247 11469-11475 RB denotes almost
T2248 11476-11482 JJ denotes normal
T2249 11493-11495 , denotes ,
T2250 11495-11499 IN denotes with
T2251 11500-11503 NN denotes TTD
T2252 11504-11508 JJ denotes like
T2253 11503-11504 HYPH denotes -
T2254 11509-11517 NNS denotes features
T2255 11518-11522 JJ denotes such
T2256 11523-11525 IN denotes as
T2257 11526-11532 JJ denotes broken
T2258 11533-11538 NNS denotes hairs
T2259 11539-11544 VBN denotes found
T2260 11545-11549 RB denotes only
T2261 11550-11552 IN denotes at
T2262 11553-11557 RB denotes very
T2263 11558-11561 JJ denotes low
T2264 11562-11571 NN denotes frequency
T2265 11572-11573 -LRB- denotes (
T2266 11585-11589 NNS denotes data
T2267 11573-11584 JJ denotes unpublished
T2268 11589-11590 -RRB- denotes )
T2269 11590-11591 . denotes .
T2270 11591-11778 sentence denotes Amino acid analysis confirmed that cysteine levels in the hair of the XpdTTD/†XPCS mice were significantly higher than in XpdTTD/TTD animals, but remained below the wt level (Figure 2C).
T2271 11592-11597 NN denotes Amino
T2272 11598-11602 NN denotes acid
T2273 11603-11611 NN denotes analysis
T2274 11612-11621 VBD denotes confirmed
T2275 11622-11626 IN denotes that
T2276 11680-11684 VBD denotes were
T2277 11627-11635 NN denotes cysteine
T2278 11636-11642 NNS denotes levels
T2279 11643-11645 IN denotes in
T2280 11646-11649 DT denotes the
T2281 11650-11654 NN denotes hair
T2282 11655-11657 IN denotes of
T2283 11658-11661 DT denotes the
T2284 11675-11679 NNS denotes mice
T2285 11662-11668 NN denotes XpdTTD
T2286 11669-11674 NN denotes †XPCS
T2287 11668-11669 HYPH denotes /
T2288 11685-11698 RB denotes significantly
T2289 11699-11705 JJR denotes higher
T2352 13263-13266 DT denotes the
T2353 13267-13272 NN denotes layer
T2354 13273-13275 IN denotes of
T2355 13276-13279 DT denotes the
T2356 13290-13295 NNS denotes cells
T2357 13280-13289 JJ denotes nucleated
T2358 13295-13296 -RRB- denotes )
T2359 13296-13298 , denotes ,
T2360 13298-13312 NN denotes hyperkeratosis
T2361 13313-13314 -LRB- denotes (
T2362 13324-13334 NN denotes thickening
T2363 13314-13323 JJ denotes prominent
T2364 13335-13337 IN denotes of
T2365 13338-13341 DT denotes the
T2366 13352-13357 NN denotes layer
T2367 13342-13351 VBN denotes cornified
T2368 13357-13358 -RRB- denotes )
T2369 13358-13360 , denotes ,
T2370 13360-13363 CC denotes and
T2371 13364-13374 JJ denotes pronounced
T2372 13384-13389 NN denotes layer
T2373 13375-13383 JJ denotes granular
T2374 13390-13393 CC denotes and
T2375 13394-13403 JJ denotes sebacious
T2376 13404-13409 NN denotes gland
T2377 13410-13421 NN denotes hyperplasia
T2378 13422-13423 -LRB- denotes (
T2379 13423-13430 VBG denotes causing
T2380 13431-13437 JJ denotes greasy
T2381 13438-13448 NN denotes appearance
T2382 13449-13451 IN denotes of
T2383 13452-13455 DT denotes the
T2384 13456-13460 NN denotes hair
T2385 13460-13461 -RRB- denotes )
T2386 13461-13463 , denotes ,
T2387 13468-13474 JJ denotes absent
T2388 13475-13477 IN denotes in
T2389 13478-13481 DT denotes the
T2390 13482-13486 NN denotes skin
T2391 13487-13489 IN denotes of
T2392 13490-13496 NN denotes XpdTTD
T2393 13497-13502 NN denotes †XPCS
T2394 13496-13497 HYPH denotes /
T2395 13503-13507 NNS denotes mice
T2396 13507-13509 , denotes ,
T2397 13509-13511 IN denotes as
T2398 13512-13523 VBN denotes established
T2399 13524-13526 IN denotes by
T2400 13527-13532 JJ denotes blind
T2401 13545-13556 NN denotes examination
T2402 13533-13544 JJ denotes microscopic
T2403 13557-13559 IN denotes of
T2404 13560-13564 NN denotes skin
T2405 13565-13573 NNS denotes sections
T2406 13574-13575 -LRB- denotes (
T2407 13582-13584 NN denotes 2B
T2408 13575-13581 NN denotes Figure
T2409 13584-13585 -RRB- denotes )
T2410 13585-13586 . denotes .
T2411 13586-13784 sentence denotes Furthermore, anaemia and developmental delay present in patients with TTD [24] and in XpdTTD/TTD mice [15] were both partially rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 2D and 2E).
T2412 13587-13598 RB denotes Furthermore
T2413 13714-13721 VBN denotes rescued
T2414 13598-13600 , denotes ,
T2415 13600-13607 NN denotes anaemia
T2416 13608-13611 CC denotes and
T2417 13612-13625 JJ denotes developmental
T2418 13626-13631 NN denotes delay
T2419 13632-13639 JJ denotes present
T2420 13640-13642 IN denotes in
T2421 13643-13651 NNS denotes patients
T2422 13652-13656 IN denotes with
T2423 13657-13660 NN denotes TTD
T2424 13661-13662 -LRB- denotes [
T2425 13662-13664 CD denotes 24
T2426 13664-13665 -RRB- denotes ]
T2427 13666-13669 CC denotes and
T2428 13670-13672 IN denotes in
T2429 13673-13679 NN denotes XpdTTD
T2430 13680-13683 NN denotes TTD
T2431 13679-13680 HYPH denotes /
T2432 13684-13688 NNS denotes mice
T2433 13689-13690 -LRB- denotes [
T2434 13690-13692 CD denotes 15
T2435 13692-13693 -RRB- denotes ]
T2436 13694-13698 VBD denotes were
T2437 13699-13703 RB denotes both
T2438 13704-13713 RB denotes partially
T2439 13722-13724 IN denotes in
T2440 13725-13733 JJ denotes compound
T2441 13760-13764 NNS denotes mice
T2442 13734-13746 JJ denotes heterozygous
T2443 13747-13753 NN denotes XpdTTD
T2444 13754-13759 NN denotes †XPCS
T2445 13753-13754 HYPH denotes /
T2446 13765-13766 -LRB- denotes (
T2447 13773-13775 NN denotes 2D
T2448 13766-13772 NN denotes Figure
T2449 13776-13779 CC denotes and
T2450 13780-13782 NN denotes 2E
T2451 13782-13783 -RRB- denotes )
T2452 13783-13784 . denotes .
T2572 0-6 NN denotes Rescue
T2573 7-9 IN denotes of
T2574 10-13805 JJ denotes Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles Compound Heterozygosity at theXpd Locus Abstract Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background. We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models. Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria. We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii) differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals. Our data suggest a re-evaluation of the contribution of “null” alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals. Effects of mutations in Xpd were investigated in mice. Compound heterozygotes of otherwise homozygous lethal alleles demonstrated interallelic complementation and partial phenotypic rescue of XPD-related disease symptoms. Introduction Interallelic complementation is defined as the ability of two differentially mutated alleles to function better together than either can on its own. Despite its near universality in lower organisms [1], its potential to contribute to clinical heterogeneity in human disease is seldom considered. Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5]. Compound heterozygotes are individuals carrying two different mutant alleles of the same gene. In the absence of a dominant (wild-type [wt]) allele, genetic interactions between recessive alleles (referred to here as “biallelic” effects) could result in different phenotypic outcomes including interallelic complementation. Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background. XPD encodes one of the two helicase components of basal transcription/DNA repair factor IIH (TFIIH), a ten-subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7]. Alterations in XPD resulting in defective TFIIH function are associated with UV-sensitive, multisystem disorders including xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD) [8–10]. XP is marked by sun-induced pigmentation anomalies and a greater than 1,000-fold elevation in skin cancer risk. Severe cases can also present with growth retardation and primary neurodegeneration [11]. CS and TTD, on the other hand, are segmental progeroid disorders characterised by progressive post-natal growth failure and primary demyelination resulting in severe neurodysfunction, but without a clear cancer predisposition [12–15]. Patients with TTD additionally display hallmark sulphur-deficient brittle hair and nails and scaling skin [13], resulting from a basal transcription defect in specific cell types [16,17]. A related disorder with the cancer predisposition of XP combined with the neurodevelopmental complications of CS (XPCS), although rare, has also been described [18]. Many XPD mutations are associated with an exclusive disease phenotype (e.g., XPDR722W with TTD and XPDR683W with XP) and are thus viewed as causative of the corresponding syndromes. Alleles not associated exclusively with one disorder are considered “likely null” alleles [19,20]. Some of these alleles fail to support viability in a haploid Schizosaccharomyces pombe yeast strain with a null mutation in the XPD homologue rad15 and are thus considered devoid of significant biological activity [19]. This classification of alleles as either causative or null currently defines what we refer to as a “monoallelic” paradigm of XPD disease. However, the identification in recent years of XP complementation group D patients with atypical disease presentation, including symptoms of both XP and TTD [8], casts doubt on the ability of such a monoallelic paradigm to explain clinical heterogeneity in compound heterozygotes. Previously, we generated a TTD mouse model (XPDR722W) that phenocopies the human syndrome [15,21]. Here we report the generation of additional mutant Xpd alleles that fail to support viability on their own but nevertheless ameliorate TTD-associated premature segmental ageing, cutaneous features, cellular DNA repair capacity, and UV survival when present in a compound heterozygote state. Results Generation of Xpd Compound Heterozygotes We generated an Xpd knock-in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A–1C). mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E). Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state. However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1). The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS). Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself. Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22]. Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data). Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23]. Figure 1 Targeting of the Mouse Xpd Gene (A) Schematic representation of the genomic structure and partial restriction map of the wt and targeted mouse Xpd loci. For the wt Xpd allele, shaded boxes represent coding regions of exons 12 and 19–23; the 3′UTR is represented by an open box. TGA indicates the translational stop codon; PolyA indicates the polyadenylation signal. For the XpdTTD targeted allele, the 194–base pair (bp) human XPD cDNA fragment fused to exon 22 is indicated as a striped box including the TTD (R722W) mutation indicated by a vertical arrow. Chicken β-globin exons 2 and 3 including the 3′UTR are indicated as black boxes with corresponding Roman numerals followed by the β-globin polyadenylation signal (PolyA*). For the Xpd†XP and Xpd†XPCS targeted alleles, vertical arrows indicate XPCS (G602D-encoding) and XP (R683W-encoding) mutations in exons 19 and 22, respectively. The unique 3′ probe located outside the targeting construct is marked by a thick black line. Restriction sites: B, BamHI; C, ClaI; E, EcoRI; H, HindIII; Hp, HpaI; Sf, SfiI. (B) Southern blot analysis of EcoRI-digested genomic DNA from wt, Xpd†XPCS/wt, and Xpd†XP/wt recombinant embryonic stem cell clones hybridised with the 3′ probe depicted in (A). The wt allele yields a 6.5-kilobase (kb) fragment, whereas both targeted Xpd†XP and Xpd†XPCS alleles yield a 5.1-kb fragment. (C) Genotyping of wt and targeted alleles by PCR using primers F2, R1, and mR as indicated in (A) yields fragments of 399 bp and 468 bp, respectively. (D) RT-PCR detection of mRNA expression originating from the targeted †XP and †XPCS alleles in embryonic stem cell clones using primers F1 (hybridising outside the targeting construct) and mR as indicated in (A) results in a 1,416-bp fragment. (E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD/TTD, heterozygous Xpd†XPCS/wt and XpdTTD/wt, and compound heterozygous Xpd†XPCS/TTD mice as indicated. Hybridisation with a 1.4-kb mouse Xpd cDNA probe detects mRNAs of 4, 3.3, and 2.7 kb from wt, Xpd†XPCS, and XpdTTD alleles, respectively. An ethidium bromide (EtBr)–stained gel showing the amount of total RNA loaded is shown below. Table 1 Frequency of Xpd†XP/†XP, Xpd†XPCS/†XPCS, and Compound Heterozygous Xpd†XP/†XPCS Embryos and Offspring “Null” Allele Can Alleviate Developmental Delay, Skin, and Hair Features of TTD To test the potential of a homozygous lethal “null” allele to nevertheless contribute to organismal phenotype, we combined an Xpd†XPCS allele with a viable XpdTTD allele by crossing the corresponding heterozygous animals. Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies. Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E). Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles. Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C). In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A). Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data). Amino acid analysis confirmed that cysteine levels in the hair of the XpdTTD/†XPCS mice were significantly higher than in XpdTTD/TTD animals, but remained below the wt level (Figure 2C). TTD hemizygotes (XpdTTD/KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD/TTD mice [21]. Figure 2 Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous XpdTTD/†XPCS Mice (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice. Insets: images of first-round hair loss. (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice. Magnification 400×. (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice. The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice. Error bars indicate standard error of the mean (SEM). (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice. The p-values indicate the significance of the difference relative to wt. Error bars indicate SEM. (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM. Other prominent TTD features in the epidermis, including acanthosis (thickening of the layer of the nucleated cells), hyperkeratosis (prominent thickening of the cornified layer), and pronounced granular layer and sebacious gland hyperplasia (causing greasy appearance of the hair), were absent in the skin of XpdTTD/†XPCS mice, as established by blind microscopic examination of skin sections (Figure 2B). Furthermore, anaemia and developmental delay present in patients with TTD [24] and in XpdTTD/TTD mice [15] were both partially rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 2D and 2E). Rescue of Progeroid
T2575 13806-13814 NNS denotes Features
T2576 13815-13817 IN denotes in
T2577 13818-13821 NN denotes TTD
T2578 13822-13826 NNS denotes Mice
T2579 13827-13829 IN denotes by
T2580 13830-13840 JJ denotes Homozygous
T2581 13852-13859 NNS denotes Alleles
T2582 13841-13847 JJ denotes Lethal
T2583 13848-13851 NN denotes Xpd
T2584 13859-14093 sentence denotes Because patients with TTD, XPCS, and CS (but not XP) and the corresponding mouse models share similar accelerated progeroid symptoms [12,13,15,23], we next addressed ageing-related parameters in compound heterozygous mice (Figure 3).
T2585 13860-13867 IN denotes Because
T2586 13948-13953 VBP denotes share
T2587 13868-13876 NNS denotes patients
T2588 13877-13881 IN denotes with
T2589 13882-13885 NN denotes TTD
T2590 13885-13887 , denotes ,
T2591 13887-13891 NN denotes XPCS
T2592 13891-13893 , denotes ,
T2593 13893-13896 CC denotes and
T2594 13897-13899 NN denotes CS
T2595 13900-13901 -LRB- denotes (
T2596 13901-13904 CC denotes but
T2597 13905-13908 RB denotes not
T2598 13909-13911 NN denotes XP
T2599 13911-13912 -RRB- denotes )
T2600 13913-13916 CC denotes and
T2601 13917-13920 DT denotes the
T2602 13941-13947 NNS denotes models
T2603 13921-13934 VBG denotes corresponding
T2604 13935-13940 NN denotes mouse
T2605 14016-14025 VBD denotes addressed
T2606 13954-13961 JJ denotes similar
T2607 13984-13992 NNS denotes symptoms
T2608 13962-13973 VBN denotes accelerated
T2609 13974-13983 NN denotes progeroid
T2610 13993-13994 -LRB- denotes [
T2611 14003-14005 CD denotes 23
T2612 13994-13996 CD denotes 12
T2613 13996-13997 , denotes ,
T2614 13997-13999 CD denotes 13
T2615 13999-14000 , denotes ,
T2616 14000-14002 CD denotes 15
T2617 14002-14003 , denotes ,
T2618 14005-14006 -RRB- denotes ]
T2619 14006-14008 , denotes ,
T2620 14008-14010 PRP denotes we
T2621 14011-14015 RB denotes next
T2622 14026-14032 JJ denotes ageing
T2623 14033-14040 JJ denotes related
T2624 14032-14033 HYPH denotes -
T2625 14041-14051 NNS denotes parameters
T2626 14052-14054 IN denotes in
T2627 14055-14063 JJ denotes compound
T2628 14077-14081 NNS denotes mice
T2629 14064-14076 JJ denotes heterozygous
T2630 14082-14083 -LRB- denotes (
T2631 14083-14089 NN denotes Figure
T2632 14090-14091 CD denotes 3
T2633 14091-14092 -RRB- denotes )
T2634 14092-14093 . denotes .
T2635 14093-14356 sentence denotes Whereas XpdTTD/TTD animals show reduced bone mineral density as an indication of the early onset of osteoporosis before ~14 mo of age [15], tail vertebrae from compound heterozygous XpdTTD/†XPCS mice were comparable to wt even at 20 mo of age (Figure 3B and 3C).
T2636 14094-14101 IN denotes Whereas
T2637 14121-14125 VBP denotes show
T2638 14102-14108 NN denotes XpdTTD
T2639 14109-14112 NN denotes TTD
T2640 14108-14109 HYPH denotes /
T2641 14113-14120 NNS denotes animals
T2642 14294-14298 VBD denotes were
T2643 14126-14133 VBN denotes reduced
T2644 14147-14154 NN denotes density
T2645 14134-14138 NN denotes bone
T2646 14139-14146 NN denotes mineral
T2647 14155-14157 IN denotes as
T2648 14158-14160 DT denotes an
T2649 14161-14171 NN denotes indication
T2650 14172-14174 IN denotes of
T2651 14175-14178 DT denotes the
T2652 14185-14190 NN denotes onset
T2653 14179-14184 JJ denotes early
T2654 14191-14193 IN denotes of
T2655 14194-14206 NN denotes osteoporosis
T2656 14207-14213 IN denotes before
T2657 14214-14215 SYM denotes ~
T2658 14215-14217 CD denotes 14
T2659 14218-14220 NNS denotes mo
T2660 14221-14223 IN denotes of
T2661 14224-14227 NN denotes age
T2662 14228-14229 -LRB- denotes [
T2663 14229-14231 CD denotes 15
T2664 14231-14232 -RRB- denotes ]
T2665 14232-14234 , denotes ,
T2666 14234-14238 NN denotes tail
T2667 14239-14248 NNS denotes vertebrae
T2668 14249-14253 IN denotes from
T2669 14254-14262 NN denotes compound
T2670 14289-14293 NNS denotes mice
T2671 14263-14275 JJ denotes heterozygous
T2672 14276-14282 NN denotes XpdTTD
T2673 14283-14288 NN denotes †XPCS
T2674 14282-14283 HYPH denotes /
T2675 14299-14309 JJ denotes comparable
T2676 14310-14312 IN denotes to
T2677 14313-14315 NN denotes wt
T2678 14316-14320 RB denotes even
T2679 14321-14323 IN denotes at
T2680 14324-14326 CD denotes 20
T2681 14327-14329 NNS denotes mo
T2682 14330-14332 IN denotes of
T2683 14333-14336 NN denotes age
T2684 14337-14338 -LRB- denotes (
T2685 14345-14347 NN denotes 3B
T2686 14338-14344 NN denotes Figure
T2687 14348-14351 CC denotes and
T2688 14352-14354 NN denotes 3C
T2689 14354-14355 -RRB- denotes )
T2690 14355-14356 . denotes .
T2691 14356-14528 sentence denotes Furthermore, whereas XpdTTD/TTD mice developed kyphosis earlier than wt animals (onset ~3 mo versus 12–20 mo), compound heterozygous XpdTTD/†XPCS mice did not (Figure 3B).
T2692 14357-14368 RB denotes Furthermore
T2693 14524-14526 NN denotes 3B
T2694 14368-14370 , denotes ,
T2695 14370-14377 IN denotes whereas
T2696 14394-14403 VBD denotes developed
T2697 14378-14384 NN denotes XpdTTD
T2698 14385-14388 NN denotes TTD
T2699 14384-14385 HYPH denotes /
T2700 14389-14393 NNS denotes mice
T2701 14404-14412 NN denotes kyphosis
T2702 14413-14420 RBR denotes earlier
T2703 14421-14425 IN denotes than
T2704 14426-14428 NN denotes wt
T2705 14429-14436 NNS denotes animals
T2706 14437-14438 -LRB- denotes (
T2707 14438-14443 NN denotes onset
T2708 14444-14445 SYM denotes ~
T2709 14445-14446 CD denotes 3
T2710 14447-14449 NNS denotes mo
T2711 14450-14456 CC denotes versus
T2712 14457-14459 CD denotes 12
T2713 14460-14462 CD denotes 20
T2714 14459-14460 SYM denotes –
T2715 14463-14465 NNS denotes mo
T2716 14465-14466 -RRB- denotes )
T2717 14466-14468 , denotes ,
T2718 14468-14476 JJ denotes compound
T2719 14503-14507 NNS denotes mice
T2720 14477-14489 JJ denotes heterozygous
T2721 14490-14496 NN denotes XpdTTD
T2722 14497-14502 NN denotes †XPCS
T2723 14496-14497 HYPH denotes /
T2724 14508-14511 VBD denotes did
T2725 14512-14515 RB denotes not
T2726 14516-14517 -LRB- denotes (
T2727 14517-14523 NN denotes Figure
T2728 14526-14527 -RRB- denotes )
T2729 14527-14528 . denotes .
T2730 14528-14740 sentence denotes Overall appearance and body weight curves revealed that TTD-associated age-related premature cachexia and lack of general fitness were fully rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 3A and 3D).
T2731 14529-14536 JJ denotes Overall
T2732 14537-14547 NN denotes appearance
T2733 14571-14579 VBD denotes revealed
T2734 14548-14551 CC denotes and
T2735 14552-14556 NN denotes body
T2736 14557-14563 NN denotes weight
T2737 14564-14570 NNS denotes curves
T2738 14580-14584 IN denotes that
T2739 14670-14677 VBN denotes rescued
T2740 14585-14588 NN denotes TTD
T2741 14589-14599 JJ denotes associated
T2742 14588-14589 HYPH denotes -
T2743 14622-14630 NN denotes cachexia
T2744 14600-14603 NN denotes age
T2745 14604-14611 JJ denotes related
T2746 14603-14604 HYPH denotes -
T2747 14612-14621 JJ denotes premature
T2748 14631-14634 CC denotes and
T2749 14635-14639 NN denotes lack
T2750 14640-14642 IN denotes of
T2751 14643-14650 JJ denotes general
T2752 14651-14658 NN denotes fitness
T2753 14659-14663 VBD denotes were
T2754 14664-14669 RB denotes fully
T2755 14678-14680 IN denotes in
T2756 14681-14689 JJ denotes compound
T2757 14716-14720 NNS denotes mice
T2758 14690-14702 JJ denotes heterozygous
T2759 14703-14709 NN denotes XpdTTD
T2822 16400-16402 IN denotes by
T2823 16403-16411 VBG denotes crossing
T2824 16412-16415 DT denotes the
T2825 16443-16450 NNS denotes animals
T2826 16416-16429 VBG denotes corresponding
T2827 16430-16442 JJ denotes heterozygous
T2828 16450-16451 . denotes .
T2829 16451-16897 sentence denotes Similar to the Xpd †XPCS allele, the homozygous lethal Xpd †XP allele rescued cutaneous symptoms including hair loss (except locally during the first round; unpublished data), reduced cysteine content (cysteine index 9.3 ± 0.9 standard deviation [87% of wt], p = 0.01 versus TTD), ageing-associated premature cachexia (males and females were 36.1 ± 6.4 g [93% of wt] and 39.2 ± 3.2 g [116% of wt], respectively), and reduced life span (Table 2).
T2830 16452-16459 JJ denotes Similar
T2831 16522-16529 VBD denotes rescued
T2832 16460-16462 IN denotes to
T2833 16463-16466 DT denotes the
T2834 16477-16483 NN denotes allele
T2835 16467-16476 NN denotes Xpd †XPCS
T2836 16483-16485 , denotes ,
T2837 16485-16488 DT denotes the
T2838 16515-16521 NN denotes allele
T2839 16489-16499 JJ denotes homozygous
T2840 16500-16506 JJ denotes lethal
T2841 16507-16514 NN denotes Xpd †XP
T2842 16530-16539 JJ denotes cutaneous
T2843 16540-16548 NNS denotes symptoms
T2844 16549-16558 VBG denotes including
T2845 16559-16563 NN denotes hair
T2846 16564-16568 NN denotes loss
T2847 16569-16570 -LRB- denotes (
T2848 16621-16625 NNS denotes data
T2849 16570-16576 IN denotes except
T2850 16577-16584 RB denotes locally
T2851 16585-16591 IN denotes during
T2852 16592-16595 DT denotes the
T2853 16602-16607 NN denotes round
T2854 16596-16601 JJ denotes first
T2855 16607-16608 : denotes ;
T2856 16609-16620 JJ denotes unpublished
T2857 16625-16626 -RRB- denotes )
T2858 16626-16628 , denotes ,
T2859 16628-16635 VBN denotes reduced
T2860 16645-16652 NN denotes content
T2861 16636-16644 NN denotes cysteine
T2862 16653-16654 -LRB- denotes (
T2863 16663-16668 NN denotes index
T2864 16654-16662 NN denotes cysteine
T2865 16669-16672 CD denotes 9.3
T2866 16673-16674 SYM denotes ±
T2867 16675-16678 CD denotes 0.9
T2868 16688-16697 NN denotes deviation
T2869 16679-16687 JJ denotes standard
T2870 16698-16699 -LRB- denotes [
T2871 16701-16702 NN denotes %
T2872 16699-16701 CD denotes 87
T2873 16703-16705 IN denotes of
T2874 16706-16708 NN denotes wt
T2875 16708-16709 -RRB- denotes ]
T2876 16709-16711 , denotes ,
T2877 16711-16712 NN denotes p
T2878 16727-16730 NN denotes TTD
T2879 16713-16714 SYM denotes =
T2880 16715-16719 CD denotes 0.01
T2881 16720-16726 CC denotes versus
T2882 16730-16731 -RRB- denotes )
T2883 16731-16733 , denotes ,
T2884 16733-16739 NN denotes ageing
T2885 16740-16750 VBN denotes associated
T2886 16739-16740 HYPH denotes -
T2887 16761-16769 NN denotes cachexia
T2888 16751-16760 JJ denotes premature
T2889 16770-16771 -LRB- denotes (
T2890 16789-16793 VBD denotes were
T2891 16771-16776 NNS denotes males
T2892 16777-16780 CC denotes and
T2893 16781-16788 NNS denotes females
T2894 16794-16798 CD denotes 36.1
T2895 16801-16804 CD denotes 6.4
T2896 16799-16800 SYM denotes ±
T2897 16805-16806 NNS denotes g
T2898 16807-16808 -LRB- denotes [
T2899 16810-16811 NN denotes %
T2900 16808-16810 CD denotes 93
T2901 16812-16814 IN denotes of
T2902 16815-16817 NN denotes wt
T2903 16817-16818 -RRB- denotes ]
T2904 16819-16822 CC denotes and
T2905 16823-16827 CD denotes 39.2
T2906 16830-16833 CD denotes 3.2
T2907 16828-16829 SYM denotes ±
T2908 16834-16835 NNS denotes g
T2909 16836-16837 -LRB- denotes [
T2910 16840-16841 NN denotes %
T2911 16837-16840 CD denotes 116
T2912 16842-16844 IN denotes of
T2913 16845-16847 NN denotes wt
T2914 16847-16848 -RRB- denotes ]
T2915 16848-16850 , denotes ,
T2916 16850-16862 RB denotes respectively
T2917 16862-16863 -RRB- denotes )
T2918 16863-16865 , denotes ,
T2919 16865-16868 CC denotes and
T2920 16869-16876 VBN denotes reduced
T2921 16882-16886 NN denotes span
T2922 16877-16881 NN denotes life
T2923 16887-16888 -LRB- denotes (
T2924 16888-16893 NN denotes Table
T2925 16894-16895 CD denotes 2
T2926 16895-16896 -RRB- denotes )
T2927 16896-16897 . denotes .
T2928 16897-17106 sentence denotes Taken together, these data indicate that two independent alleles, which on their own are unable to support viability (Table 1), were nonetheless able to ameliorate TTD-associated phenotypes in vivo (Table 2).
T2929 16898-16903 VBN denotes Taken
T2930 16925-16933 VBP denotes indicate
T2931 16904-16912 RB denotes together
T2932 16912-16914 , denotes ,
T2933 16914-16919 DT denotes these
T2934 16920-16924 NNS denotes data
T2935 16934-16938 IN denotes that
T2936 17026-17030 VBD denotes were
T2937 16939-16942 CD denotes two
T2938 16955-16962 NNS denotes alleles
T2939 16943-16954 JJ denotes independent
T2940 16962-16964 , denotes ,
T2941 16964-16969 WDT denotes which
T2942 16983-16986 VBP denotes are
T2943 16970-16972 IN denotes on
T2944 16973-16978 PRP$ denotes their
T2945 16979-16982 NN denotes own
T2946 16987-16993 JJ denotes unable
T2947 16994-16996 TO denotes to
T2948 16997-17004 VB denotes support
T2949 17005-17014 NN denotes viability
T2950 17015-17016 -LRB- denotes (
T2951 17016-17021 NN denotes Table
T2952 17022-17023 CD denotes 1
T2953 17023-17024 -RRB- denotes )
T2954 17024-17026 , denotes ,
T2955 17031-17042 RB denotes nonetheless
T2956 17043-17047 JJ denotes able
T2957 17048-17050 TO denotes to
T2958 17051-17061 VB denotes ameliorate
T2959 17062-17065 NN denotes TTD
T2960 17066-17076 VBN denotes associated
T2961 17065-17066 HYPH denotes -
T2962 17077-17087 NNS denotes phenotypes
T2963 17088-17090 FW denotes in
T2964 17091-17095 FW denotes vivo
T2965 17096-17097 -LRB- denotes (
T2966 17097-17102 NN denotes Table
T2967 17103-17104 CD denotes 2
T2968 17104-17105 -RRB- denotes )
T2969 17105-17106 . denotes .
T3312 17108-17117 JJ denotes Molecular
T3313 17118-17128 NNS denotes Mechanisms
T3314 17129-17131 IN denotes of
T3315 17132-17141 JJ denotes Biallelic
T3316 17142-17149 NNS denotes Effects
T3317 17149-17448 sentence denotes We next turned to UV-based cellular assays including unscheduled DNA synthesis after UV irradiation (UV-UDS), recovery of RNA synthesis after UV irradiation (UV-RRS), and UV survival, which report on the NER subpathways (global genome NER and transcription-coupled NER) and total NER, respectively.
T3318 17150-17152 PRP denotes We
T3319 17158-17164 VBD denotes turned
T3320 17153-17157 RB denotes next
T3321 17165-17167 IN denotes to
T3322 17168-17170 NN denotes UV
T3323 17171-17176 VBN denotes based
T3324 17170-17171 HYPH denotes -
T3325 17186-17192 NNS denotes assays
T3326 17177-17185 JJ denotes cellular
T3327 17193-17202 VBG denotes including
T3328 17203-17214 JJ denotes unscheduled
T3329 17219-17228 NN denotes synthesis
T3330 17215-17218 NN denotes DNA
T3331 17229-17234 IN denotes after
T3332 17235-17237 NN denotes UV
T3333 17238-17249 NN denotes irradiation
T3334 17250-17251 -LRB- denotes (
T3335 17254-17257 NN denotes UDS
T3336 17251-17253 NN denotes UV
T3337 17253-17254 HYPH denotes -
T3338 17257-17258 -RRB- denotes )
T3339 17258-17260 , denotes ,
T3340 17260-17268 NN denotes recovery
T3341 17269-17271 IN denotes of
T3342 17272-17275 NN denotes RNA
T3343 17276-17285 NN denotes synthesis
T3344 17286-17291 IN denotes after
T3345 17292-17294 NN denotes UV
T3346 17295-17306 NN denotes irradiation
T3347 17307-17308 -LRB- denotes (
T3348 17311-17314 NN denotes RRS
T3349 17308-17310 NN denotes UV
T3350 17310-17311 HYPH denotes -
T3351 17314-17315 -RRB- denotes )
T3352 17315-17317 , denotes ,
T3353 17317-17320 CC denotes and
T3354 17321-17323 NN denotes UV
T3355 17324-17332 NN denotes survival
T3356 17332-17334 , denotes ,
T3357 17334-17339 WDT denotes which
T3358 17340-17346 VBP denotes report
T3359 17347-17349 IN denotes on
T3360 17350-17353 DT denotes the
T3361 17358-17369 NNS denotes subpathways
T3362 17354-17357 NN denotes NER
T3363 17370-17371 -LRB- denotes (
T3364 17385-17388 NN denotes NER
T3365 17371-17377 JJ denotes global
T3366 17378-17384 NN denotes genome
T3367 17389-17392 CC denotes and
T3368 17393-17406 NN denotes transcription
T3369 17407-17414 VBN denotes coupled
T3370 17406-17407 HYPH denotes -
T3371 17415-17418 NN denotes NER
T3372 17418-17419 -RRB- denotes )
T3373 17420-17423 CC denotes and
T3374 17424-17429 JJ denotes total
T3375 17430-17433 NN denotes NER
T3376 17433-17435 , denotes ,
T3377 17435-17447 RB denotes respectively
T3378 17447-17448 . denotes .
T3379 17448-17574 sentence denotes In none of these assays was the response to UV improved in compound heterozygotes relative to TTD homozygotes (Figure 4A–4C).
T3380 17449-17451 IN denotes In
T3381 17496-17504 VBN denotes improved
T3382 17452-17456 NN denotes none
T3383 17457-17459 IN denotes of
T3384 17460-17465 DT denotes these
T3385 17466-17472 NNS denotes assays
T3386 17473-17476 VBD denotes was
T3387 17477-17480 DT denotes the
T3388 17481-17489 NN denotes response
T3389 17490-17492 IN denotes to
T3390 17493-17495 NN denotes UV
T3391 17505-17507 IN denotes in
T3392 17508-17516 NN denotes compound
T3393 17517-17530 NNS denotes heterozygotes
T3394 17531-17539 JJ denotes relative
T3395 17540-17542 IN denotes to
T3396 17543-17546 NN denotes TTD
T3397 17547-17558 NNS denotes homozygotes
T3398 17559-17560 -LRB- denotes (
T3399 17567-17569 NN denotes 4A
T3400 17560-17566 NN denotes Figure
T3401 17569-17570 SYM denotes –
T3402 17570-17572 NN denotes 4C
T3403 17572-17573 -RRB- denotes )
T3404 17573-17574 . denotes .
T3405 17574-17920 sentence denotes However, unlike the in vivo TTD phenotypes described above, in which XpdTTD/TTD and XpdTTD/KO animals were indistinguishable, XpdTTD dosage effects were observed in UV survival, UV-UDS, and UV-RRS, indicating that cellular parameters as measured in fibroblasts here do not always correlate with the phenotype at the level of the intact organism.
T3406 17575-17582 RB denotes However
T3407 17728-17736 VBN denotes observed
T3408 17582-17584 , denotes ,
T3409 17584-17590 IN denotes unlike
T3410 17591-17594 DT denotes the
T3411 17607-17617 NNS denotes phenotypes
T3412 17595-17597 FW denotes in
T3413 17598-17602 FW denotes vivo
T3414 17603-17606 NN denotes TTD
T3415 17618-17627 VBN denotes described
T3416 17628-17633 RB denotes above
T3417 17633-17635 , denotes ,
T3418 17635-17637 IN denotes in
T3419 17677-17681 VBD denotes were
T3420 17638-17643 WDT denotes which
T3421 17644-17650 NN denotes XpdTTD
T3422 17651-17654 NN denotes TTD
T3423 17650-17651 HYPH denotes /
T3424 17669-17676 NNS denotes animals
T3425 17655-17658 CC denotes and
T3426 17659-17665 NN denotes XpdTTD
T3427 17666-17668 NN denotes KO
T3428 17665-17666 HYPH denotes /
T3429 17682-17699 JJ denotes indistinguishable
T3430 17699-17701 , denotes ,
T3431 17701-17707 NN denotes XpdTTD
T3432 17715-17722 NNS denotes effects
T3433 17708-17714 NN denotes dosage
T3434 17723-17727 VBD denotes were
T3435 17737-17739 IN denotes in
T3436 17740-17742 NN denotes UV
T3437 17743-17751 NN denotes survival
T3438 17751-17753 , denotes ,
T3439 17753-17755 NN denotes UV
T3440 17756-17759 NN denotes UDS
T3441 17755-17756 HYPH denotes -
T3442 17759-17761 , denotes ,
T3443 17761-17764 CC denotes and
T3444 17765-17767 NN denotes UV
T3445 17768-17771 NN denotes RRS
T3446 17767-17768 HYPH denotes -
T3447 17771-17773 , denotes ,
T3448 17773-17783 VBG denotes indicating
T3449 17784-17788 IN denotes that
T3450 17855-17864 VB denotes correlate
T3451 17789-17797 JJ denotes cellular
T3452 17798-17808 NNS denotes parameters
T3453 17809-17811 IN denotes as
T3454 17812-17820 VBN denotes measured
T3455 17821-17823 IN denotes in
T3456 17824-17835 NNS denotes fibroblasts
T3457 17836-17840 RB denotes here
T3458 17841-17843 VBP denotes do
T3459 17844-17847 RB denotes not
T3460 17848-17854 RB denotes always
T3461 17865-17869 IN denotes with
T3462 17870-17873 DT denotes the
T3463 17874-17883 NN denotes phenotype
T3464 17884-17886 IN denotes at
T3465 17887-17890 DT denotes the
T3466 17891-17896 NN denotes level
T3467 17897-17899 IN denotes of
T3468 17900-17903 DT denotes the
T3469 17911-17919 NN denotes organism
T3470 17904-17910 JJ denotes intact
T3471 17919-17920 . denotes .
T3472 17920-18043 sentence denotes XpdTTD/KO hemizygous cells were thus used as the baseline on which to compare the activity of compound heterozygous cells.
T3473 17921-17927 NN denotes XpdTTD
T3474 17928-17930 NN denotes KO
T3475 17927-17928 HYPH denotes /
T3476 17942-17947 NNS denotes cells
T3477 17931-17941 JJ denotes hemizygous
T3478 17958-17962 VBN denotes used
T3479 17948-17952 VBD denotes were
T3480 17953-17957 RB denotes thus
T3481 17963-17965 IN denotes as
T3482 17966-17969 DT denotes the
T3483 17970-17978 NN denotes baseline
T3484 17979-17981 IN denotes on
T3485 17991-17998 VB denotes compare
T3486 17982-17987 WDT denotes which
T3487 17988-17990 TO denotes to
T3488 17999-18002 DT denotes the
T3489 18003-18011 NN denotes activity
T3490 18012-18014 IN denotes of
T3491 18015-18023 NN denotes compound
T3492 18037-18042 NNS denotes cells
T3493 18024-18036 JJ denotes heterozygous
T3494 18042-18043 . denotes .
T3495 18043-18250 sentence denotes Relative to XpdTTD/KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd†XPCS allele in XpdTTD/†XPCS compound heterozygous cells and to a lesser degree by the Xpd†XP allele (Figure 4A).
T3496 18044-18052 JJ denotes Relative
T3497 18100-18108 VBN denotes improved
T3498 18053-18055 IN denotes to
T3499 18056-18062 NN denotes XpdTTD
T3500 18063-18065 NN denotes KO
T3501 18062-18063 HYPH denotes /
T3502 18077-18082 NNS denotes cells
T3503 18066-18076 NN denotes hemizygote
T3504 18082-18084 , denotes ,
T3505 18084-18086 NN denotes UV
T3506 18087-18095 NN denotes survival
T3507 18096-18099 VBD denotes was
T3508 18109-18111 IN denotes by
T3509 18112-18115 DT denotes the
T3510 18143-18149 NN denotes allele
T3511 18116-18126 JJ denotes homozygous
T3512 18127-18133 JJ denotes lethal
T3513 18134-18142 NN denotes Xpd†XPCS
T3514 18150-18152 IN denotes in
T3515 18153-18159 NN denotes XpdTTD
T3516 18160-18165 NN denotes †XPCS
T3517 18159-18160 HYPH denotes /
T3518 18188-18193 NNS denotes cells
T3519 18166-18174 NN denotes compound
T3520 18175-18187 JJ denotes heterozygous
T3521 18194-18197 CC denotes and
T3522 18198-18200 IN denotes to
T3523 18217-18219 IN denotes by
T3524 18201-18202 DT denotes a
T3525 18210-18216 NN denotes degree
T3526 18203-18209 JJR denotes lesser
T3527 18220-18223 DT denotes the
T3528 18231-18237 NN denotes allele
T3529 18224-18230 NN denotes Xpd†XP
T3530 18238-18239 -LRB- denotes (
T3531 18246-18248 NN denotes 4A
T3532 18239-18245 NN denotes Figure
T3533 18248-18249 -RRB- denotes )
T3534 18249-18250 . denotes .
T3535 18250-18390 sentence denotes Because of embryonic and cellular lethality, we were unable to test UV survival associated exclusively with the Xpd†XPCS or Xpd†XP alleles.
T3536 18251-18258 IN denotes Because
T3537 18299-18303 VBD denotes were
T3538 18259-18261 IN denotes of
T3539 18262-18271 JJ denotes embryonic
T3540 18285-18294 NN denotes lethality
T3541 18272-18275 CC denotes and
T3542 18276-18284 JJ denotes cellular
T3543 18294-18296 , denotes ,
T3544 18296-18298 PRP denotes we
T3545 18304-18310 JJ denotes unable
T3546 18311-18313 TO denotes to
T3547 18314-18318 VB denotes test
T3548 18319-18321 NN denotes UV
T3549 18322-18330 NN denotes survival
T3550 18331-18341 VBN denotes associated
T3551 18342-18353 RB denotes exclusively
T3552 18354-18358 IN denotes with
T3553 18359-18362 DT denotes the
T3554 18382-18389 NNS denotes alleles
T3555 18363-18371 NN denotes Xpd†XPCS
T3556 18372-18374 CC denotes or
T3557 18375-18381 NN denotes Xpd†XP
T3558 18389-18390 . denotes .
T3559 18390-18632 sentence denotes However, homozygous XPDXP (XPDR683W) and hemizygous XPDXPCS (XPDG602D) human cells are known to be highly sensitive to UV [19,25], as are cells from a homozygous viable XpdXPCS/XPCS (XPDG602D/G602D) mouse model (Figure 4A, dotted line) [23].
T3560 18391-18398 RB denotes However
T3561 18478-18483 VBN denotes known
T3562 18398-18400 , denotes ,
T3563 18400-18410 JJ denotes homozygous
T3564 18411-18416 NN denotes XPDXP
T3565 18468-18473 NNS denotes cells
T3566 18417-18418 -LRB- denotes (
T3567 18418-18426 NN denotes XPDR683W
T3568 18426-18427 -RRB- denotes )
T3569 18428-18431 CC denotes and
T3570 18432-18442 JJ denotes hemizygous
T3571 18443-18450 NN denotes XPDXPCS
T3572 18451-18452 -LRB- denotes (
T3573 18452-18460 NN denotes XPDG602D
T3574 18460-18461 -RRB- denotes )
T3575 18462-18467 JJ denotes human
T3576 18474-18477 VBP denotes are
T3577 18484-18486 TO denotes to
T3578 18487-18489 VB denotes be
T3579 18490-18496 RB denotes highly
T3580 18497-18506 JJ denotes sensitive
T3581 18507-18509 IN denotes to
T3582 18510-18512 NN denotes UV
T3583 18513-18514 -LRB- denotes [
T3584 18517-18519 CD denotes 25
T3585 18514-18516 CD denotes 19
T3586 18516-18517 , denotes ,
T3587 18519-18520 -RRB- denotes ]
T3588 18520-18522 , denotes ,
T3589 18522-18524 IN denotes as
T3590 18525-18528 VBP denotes are
T3591 18529-18534 NNS denotes cells
T3592 18535-18539 IN denotes from
T3593 18540-18541 DT denotes a
T3594 18596-18601 NN denotes model
T3595 18542-18552 JJ denotes homozygous
T3596 18553-18559 JJ denotes viable
T3597 18560-18567 NN denotes XpdXPCS
T3598 18568-18572 NN denotes XPCS
T3599 18567-18568 HYPH denotes /
T3600 18573-18574 -LRB- denotes (
T3601 18583-18588 NN denotes G602D
T3602 18574-18582 NN denotes XPDG602D
T3603 18582-18583 HYPH denotes /
T3604 18588-18589 -RRB- denotes )
T3605 18590-18595 NN denotes mouse
T3606 18602-18603 -LRB- denotes (
T3607 18610-18612 NN denotes 4A
T3608 18603-18609 NN denotes Figure
T3609 18612-18614 , denotes ,
T3610 18614-18620 VBN denotes dotted
T3611 18621-18625 NN denotes line
T3612 18625-18626 -RRB- denotes )
T3613 18627-18628 -LRB- denotes [
T3614 18628-18630 CD denotes 23
T3615 18630-18631 -RRB- denotes ]
T3616 18631-18632 . denotes .
T3617 18632-18793 sentence denotes Thus, the survival of XpdTTD/†XPCS (and XpdTTD/†XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).
T3618 18633-18637 RB denotes Thus
T3619 18698-18708 VBZ denotes represents
T3620 18637-18639 , denotes ,
T3621 18639-18642 DT denotes the
T3622 18643-18651 NN denotes survival
T3623 18652-18654 IN denotes of
T3624 18655-18661 NN denotes XpdTTD
T3625 18662-18667 NN denotes †XPCS
T3626 18661-18662 HYPH denotes /
T3627 18685-18690 NNS denotes cells
T3628 18668-18669 -LRB- denotes (
T3629 18669-18672 CC denotes and
T3630 18673-18679 NN denotes XpdTTD
T3631 18680-18683 NN denotes †XP
T3632 18679-18680 HYPH denotes /
T3633 18683-18684 -RRB- denotes )
T3634 18691-18697 RB denotes likely
T3635 18709-18710 DT denotes a
T3636 18711-18716 NN denotes level
T3637 18717-18719 IN denotes of
T3638 18720-18722 NN denotes UV
T3639 18723-18733 NN denotes resistance
T3640 18734-18738 WDT denotes that
T3641 18765-18771 VB denotes impart
T3642 18739-18746 CC denotes neither
T3643 18754-18760 NN denotes allele
T3644 18747-18753 JJ denotes mutant
T3645 18761-18764 MD denotes can
T3646 18772-18774 IN denotes on
T3647 18775-18778 PRP$ denotes its
T3648 18779-18782 NN denotes own
T3649 18783-18784 -LRB- denotes (
T3650 18784-18789 NN denotes Table
T3651 18790-18791 CD denotes 2
T3652 18791-18792 -RRB- denotes )
T3653 18792-18793 . denotes .
T3654 18793-18951 sentence denotes Significant effects of compound heterozygosity on NER subpathways relative to XpdTTD/KO cells were observed in XpdTTD/†XP cells but only for UV-UDS activity.
T3655 18794-18805 JJ denotes Significant
T3656 18806-18813 NNS denotes effects
T3657 18893-18901 VBN denotes observed
T3658 18814-18816 IN denotes of
T3659 18817-18825 NN denotes compound
T3660 18826-18840 NN denotes heterozygosity
T3661 18841-18843 IN denotes on
T3662 18844-18847 NN denotes NER
T3663 18848-18859 NNS denotes subpathways
T3664 18860-18868 JJ denotes relative
T3665 18869-18871 IN denotes to
T3666 18872-18878 NN denotes XpdTTD
T3667 18879-18881 NN denotes KO
T3668 18878-18879 HYPH denotes /
T3669 18882-18887 NNS denotes cells
T3670 18888-18892 VBD denotes were
T3671 18902-18904 IN denotes in
T3672 18905-18911 NN denotes XpdTTD
T3673 18912-18915 NN denotes †XP
T3674 18911-18912 HYPH denotes /
T3675 18916-18921 NNS denotes cells
T3676 18922-18925 CC denotes but
T3677 18926-18930 RB denotes only
T3678 18931-18934 IN denotes for
T3679 18935-18937 NN denotes UV
T3680 18938-18941 NN denotes UDS
T3681 18937-18938 HYPH denotes -
T3682 18942-18950 NN denotes activity
T3683 18950-18951 . denotes .
T3684 18951-19200 sentence denotes Finally, none of the mutant TFIIH combinations (carrying alterations associated with TTD [XPDR722W], XPCS [XPDG602D], or XP [XPDR683W]) exhibited synergism in an in vitro NER reaction reconstituted with different mutant TFIIH complexes (Figure 4D).
T3685 18952-18959 RB denotes Finally
T3686 19088-19097 VBD denotes exhibited
T3687 18959-18961 , denotes ,
T3688 18961-18965 NN denotes none
T3689 18966-18968 IN denotes of
T3690 18969-18972 DT denotes the
T3691 18986-18998 NNS denotes combinations
T3692 18973-18979 JJ denotes mutant
T3693 18980-18985 NN denotes TFIIH
T3694 18999-19000 -LRB- denotes (
T3695 19000-19008 VBG denotes carrying
T3696 19009-19020 NNS denotes alterations
T3697 19021-19031 VBN denotes associated
T3698 19032-19036 IN denotes with
T3699 19037-19040 NN denotes TTD
T3700 19041-19042 -LRB- denotes [
T3701 19042-19050 NN denotes XPDR722W
T3702 19050-19051 -RRB- denotes ]
T3703 19051-19053 , denotes ,
T3704 19053-19057 NN denotes XPCS
T3705 19058-19059 -LRB- denotes [
T3706 19059-19067 NN denotes XPDG602D
T3707 19067-19068 -RRB- denotes ]
T3708 19068-19070 , denotes ,
T3709 19070-19072 CC denotes or
T3710 19073-19075 NN denotes XP
T3711 19076-19077 -LRB- denotes [
T3712 19077-19085 NN denotes XPDR683W
T3713 19085-19086 -RRB- denotes ]
T3714 19086-19087 -RRB- denotes )
T3715 19098-19107 NN denotes synergism
T3716 19108-19110 IN denotes in
T3717 19111-19113 DT denotes an
T3718 19127-19135 NN denotes reaction
T3719 19114-19116 FW denotes in
T3720 19117-19122 FW denotes vitro
T3721 19123-19126 NN denotes NER
T3722 19136-19149 VBN denotes reconstituted
T3723 19150-19154 IN denotes with
T3724 19155-19164 JJ denotes different
T3725 19178-19187 NNS denotes complexes
T3726 19165-19171 JJ denotes mutant
T3727 19172-19177 NN denotes TFIIH
T3728 19188-19189 -LRB- denotes (
T3729 19196-19198 NN denotes 4D
T3730 19189-19195 NN denotes Figure
T3731 19198-19199 -RRB- denotes )
T3732 19199-19200 . denotes .
T3733 19200-19435 sentence denotes Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV-related repair characteristics and TTD progeroid phenotypes in animal models.
T3734 19201-19206 VBN denotes Taken
T3735 19228-19231 VBP denotes are
T3872 22603-22611 NNS denotes patients
T3873 22612-22616 IN denotes with
T3874 22617-22620 NN denotes TTD
T3875 22621-22629 VBN denotes compared
T3876 22630-22634 IN denotes with
T3877 22635-22637 NN denotes wt
T3878 22638-22646 NNS denotes controls
T3879 22647-22650 IN denotes due
T3880 22651-22653 IN denotes to
T3881 22654-22661 VBN denotes reduced
T3882 22662-22671 NN denotes stability
T3883 22672-22673 -LRB- denotes [
T3884 22676-22678 CD denotes 17
T3885 22673-22675 CD denotes 16
T3886 22675-22676 , denotes ,
T3887 22678-22679 -RRB- denotes ]
T3888 22679-22680 . denotes .
T3889 22680-22934 sentence denotes Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50% in primary mouse XpdTTD/TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.
T3890 22681-22688 IN denotes Despite
T3891 22800-22807 VBN denotes reduced
T3892 22689-22703 NN denotes overexpression
T3893 22704-22706 IN denotes of
T3894 22707-22711 NN denotes mRNA
T3895 22712-22716 IN denotes from
T3896 22717-22720 DT denotes the
T3897 22728-22734 NN denotes allele
T3898 22721-22727 NN denotes XpdTTD
T3899 22735-22743 JJ denotes relative
T3900 22744-22746 IN denotes to
T3901 22747-22750 DT denotes the
T3902 22754-22760 NN denotes allele
T3903 22751-22753 NN denotes wt
T3904 22761-22762 -LRB- denotes (
T3905 22769-22771 NN denotes 1E
T3906 22762-22768 NN denotes Figure
T3907 22771-22772 -RRB- denotes )
T3908 22772-22774 , denotes ,
T3909 22774-22779 NN denotes TFIIH
T3910 22788-22794 NNS denotes levels
T3911 22780-22787 NN denotes protein
T3912 22795-22799 VBD denotes were
T3913 22808-22810 IN denotes by
T3914 22811-22813 CD denotes 50
T3915 22813-22814 NN denotes %
T3916 22815-22817 IN denotes in
T3917 22818-22825 JJ denotes primary
T3918 22843-22854 NNS denotes fibroblasts
T3919 22826-22831 NN denotes mouse
T3920 22832-22838 NN denotes XpdTTD
T3921 22839-22842 NN denotes TTD
T3922 22838-22839 HYPH denotes /
T3923 22855-22856 -LRB- denotes (
T3924 22863-22865 NN denotes 4E
T3925 22856-22862 NN denotes Figure
T3926 22866-22869 CC denotes and
T3927 22870-22872 NN denotes 4F
T3928 22872-22873 -RRB- denotes )
T3929 22873-22875 , denotes ,
T3930 22875-22882 RB denotes thereby
T3931 22883-22892 VBG denotes mimicking
T3932 22893-22896 DT denotes the
T3933 22897-22906 NN denotes situation
T3934 22907-22909 IN denotes in
T3935 22910-22915 JJ denotes human
T3936 22916-22924 NNS denotes patients
T3937 22925-22929 IN denotes with
T3938 22930-22933 NN denotes TTD
T3939 22933-22934 . denotes .
T3940 22934-23063 sentence denotes In accordance with the gene dosage, a further reduction of up to 70% of the wt level was observed in hemizygous XpdTTD/KO cells.
T3941 22935-22937 IN denotes In
T3942 23024-23032 VBN denotes observed
T3943 22938-22948 NN denotes accordance
T3944 22949-22953 IN denotes with
T3945 22954-22957 DT denotes the
T3946 22963-22969 NN denotes dosage
T3947 22958-22962 NN denotes gene
T3948 22969-22971 , denotes ,
T3949 22971-22972 DT denotes a
T3950 22981-22990 NN denotes reduction
T3951 22973-22980 JJ denotes further
T3952 22991-22993 IN denotes of
T3953 22994-22996 IN denotes up
T3954 23000-23002 CD denotes 70
T3955 22997-22999 IN denotes to
T3956 23002-23003 NN denotes %
T3957 23004-23006 IN denotes of
T3958 23007-23010 DT denotes the
T3959 23014-23019 NN denotes level
T3960 23011-23013 NN denotes wt
T3961 23020-23023 VBD denotes was
T3962 23033-23035 IN denotes in
T3963 23036-23046 JJ denotes hemizygous
T3964 23057-23062 NNS denotes cells
T3965 23047-23053 NN denotes XpdTTD
T3966 23054-23056 NN denotes KO
T3967 23053-23054 HYPH denotes /
T3968 23062-23063 . denotes .
T3969 23063-23257 sentence denotes Consistent with low mRNA expression levels, neither the Xpd†XPCS nor the Xpd†XP allele was able to restore TFIIH abundance to wt levels in XpdTTD compound heterozygote cells (Figure 4E and 4F).
T3970 23064-23074 JJ denotes Consistent
T3971 23151-23154 VBD denotes was
T3972 23075-23079 IN denotes with
T3973 23080-23083 JJ denotes low
T3974 23100-23106 NNS denotes levels
T3975 23084-23088 NN denotes mRNA
T3976 23089-23099 NN denotes expression
T3977 23106-23108 , denotes ,
T3978 23108-23115 CC denotes neither
T3979 23144-23150 NN denotes allele
T3980 23116-23119 DT denotes the
T3981 23120-23128 NN denotes Xpd†XPCS
T3982 23129-23132 CC denotes nor
T3983 23133-23136 DT denotes the
T3984 23137-23143 NN denotes Xpd†XP
T3985 23155-23159 JJ denotes able
T3986 23160-23162 TO denotes to
T3987 23163-23170 VB denotes restore
T3988 23171-23176 NN denotes TFIIH
T3989 23177-23186 NN denotes abundance
T3990 23187-23189 IN denotes to
T3991 23190-23192 NN denotes wt
T3992 23193-23199 NNS denotes levels
T3993 23200-23202 IN denotes in
T3994 23203-23209 NN denotes XpdTTD
T3995 23232-23237 NNS denotes cells
T3996 23210-23218 NN denotes compound
T3997 23219-23231 NN denotes heterozygote
T3998 23238-23239 -LRB- denotes (
T3999 23246-23248 NN denotes 4E
T4000 23239-23245 NN denotes Figure
T4001 23249-23252 CC denotes and
T4002 23253-23255 NN denotes 4F
T4003 23255-23256 -RRB- denotes )
T4004 23256-23257 . denotes .
T4005 23257-23534 sentence denotes Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.
T4006 23258-23262 RB denotes Thus
T4007 23400-23404 VBD denotes were
T4008 23262-23264 , denotes ,
T4009 23264-23267 DT denotes the
T4010 23280-23288 NN denotes survival
T4011 23268-23276 VBN denotes improved
T4012 23277-23279 NN denotes UV
T4013 23289-23297 VBN denotes observed
T4014 23298-23300 IN denotes in
T4015 23301-23309 NN denotes compound
T4016 23323-23328 NNS denotes cells
T4017 23310-23322 NN denotes heterozygote
T4018 23329-23330 -LRB- denotes (
T4019 23337-23339 NN denotes 4A
T4020 23330-23336 NN denotes Figure
T4021 23339-23340 -RRB- denotes )
T4022 23341-23344 CC denotes and
T4023 23345-23351 RB denotes likely
T4024 23356-23362 NN denotes rescue
T4025 23352-23355 DT denotes the
T4026 23363-23365 IN denotes of
T4027 23366-23369 NN denotes TTD
T4028 23380-23388 NNS denotes symptoms
T4029 23370-23379 NN denotes progeroid
T4030 23389-23390 -LRB- denotes (
T4031 23390-23396 NN denotes Figure
T4032 23397-23398 CD denotes 3
T4033 23398-23399 -RRB- denotes )
T4034 23405-23408 RB denotes not
T4035 23409-23412 IN denotes due
T4036 23413-23415 IN denotes to
T4037 23416-23429 NN denotes normalisation
T4038 23430-23432 IN denotes of
T4039 23433-23438 NN denotes TFIIH
T4040 23439-23445 NNS denotes levels
T4041 23445-23447 , denotes ,
T4042 23447-23457 VBG denotes suggesting
T4043 23458-23459 DT denotes a
T4044 23460-23471 JJ denotes qualitative
T4045 23499-23505 NN denotes effect
T4046 23472-23478 RB denotes rather
T4047 23479-23483 IN denotes than
T4048 23484-23485 DT denotes a
T4049 23486-23498 JJ denotes quantitative
T4050 23506-23508 IN denotes on
T4051 23509-23514 DT denotes these
T4052 23515-23525 NNS denotes phenotypes
T4053 23526-23528 FW denotes in
T4054 23529-23533 FW denotes vivo
T4055 23533-23534 . denotes .
T4056 23534-23683 sentence denotes In contrast, the level of XPCS mRNA expression did affect the ability of the encoded protein (XPDG602D) to restore the TTD hair phenotype to normal.
T4057 23535-23537 IN denotes In
T4058 23586-23592 VB denotes affect
T4059 23538-23546 NN denotes contrast
T4060 23546-23548 , denotes ,
T4061 23548-23551 DT denotes the
T4062 23552-23557 NN denotes level
T4063 23558-23560 IN denotes of
T4064 23561-23565 NN denotes XPCS
T4065 23571-23581 NN denotes expression
T4066 23566-23570 NN denotes mRNA
T4067 23582-23585 VBD denotes did
T4068 23593-23596 DT denotes the
T4069 23597-23604 NN denotes ability
T4070 23605-23607 IN denotes of
T4071 23608-23611 DT denotes the
T4072 23620-23627 NN denotes protein
T4073 23612-23619 VBN denotes encoded
T4074 23628-23629 -LRB- denotes (
T4075 23629-23637 NN denotes XPDG602D
T4076 23637-23638 -RRB- denotes )
T4077 23639-23641 TO denotes to
T4078 23642-23649 VB denotes restore
T4079 23650-23653 DT denotes the
T4080 23663-23672 NN denotes phenotype
T4081 23654-23657 NN denotes TTD
T4082 23658-23662 NN denotes hair
T4083 23673-23675 IN denotes to
T4086 23683-23946 sentence denotes Notably, XpdTTD/ †XPCS animals had a partial TTD hair phenotype, correlating with low levels of Xpd†XPCS expression, whereas XpdTTD/XPCS animals had wt hair, correlating with normal expression levels from the viable XpdXPCS allele (Table 2 and unpublished data).
T4087 23684-23691 RB denotes Notably
T4088 23715-23718 VBD denotes had
T4089 23691-23693 , denotes ,
T4090 23693-23699 NN denotes XpdTTD
T4091 23700-23706 NN denotes  †XPCS
T4092 23699-23700 HYPH denotes /
T4093 23707-23714 NNS denotes animals
T4094 23719-23720 DT denotes a
T4095 23738-23747 NN denotes phenotype
T4096 23721-23728 JJ denotes partial
T4097 23729-23732 NN denotes TTD
T4098 23733-23737 NN denotes hair
T4099 23747-23749 , denotes ,
T4100 23749-23760 VBG denotes correlating
T4101 23761-23765 IN denotes with
T4102 23766-23769 JJ denotes low
T4103 23770-23776 NNS denotes levels
T4104 23777-23779 IN denotes of
T4105 23780-23788 NN denotes Xpd†XPCS
T4106 23789-23799 NN denotes expression
T4107 23799-23801 , denotes ,
T4108 23801-23808 IN denotes whereas
T4109 23829-23832 VBD denotes had
T4110 23809-23815 NN denotes XpdTTD
T4111 23816-23820 NN denotes XPCS
T4112 23815-23816 HYPH denotes /
T4113 23821-23828 NNS denotes animals
T4114 23833-23835 NN denotes wt
T4115 23836-23840 NN denotes hair
T4116 23840-23842 , denotes ,
T4117 23842-23853 VBG denotes correlating
T4118 23854-23858 IN denotes with
T4119 23859-23865 JJ denotes normal
T4120 23877-23883 NNS denotes levels
T4121 23866-23876 NN denotes expression
T4122 23884-23888 IN denotes from
T4123 23889-23892 DT denotes the
T4124 23908-23914 NN denotes allele
T4125 23893-23899 JJ denotes viable
T4126 23900-23907 NN denotes XpdXPCS
T4127 23915-23916 -LRB- denotes (
T4128 23916-23921 NN denotes Table
T4129 23922-23923 CD denotes 2
T4130 23924-23927 CC denotes and
T4131 23928-23939 JJ denotes unpublished
T4132 23940-23944 NNS denotes data
T4133 23944-23945 -RRB- denotes )
T4134 23945-23946 . denotes .
T4135 23946-24074 sentence denotes Thus, the range of expression levels from these two mutant alleles affected their ability to complement some phenotypes (hair).
T4136 23947-23951 RB denotes Thus
T4137 24014-24022 VBD denotes affected
T4138 23951-23953 , denotes ,
T4139 23953-23956 DT denotes the
T4140 23957-23962 NN denotes range
T4141 23963-23965 IN denotes of
T4142 23966-23976 NN denotes expression
T4143 23977-23983 NNS denotes levels
T4144 23984-23988 IN denotes from
T4145 23989-23994 DT denotes these
T4146 24006-24013 NNS denotes alleles
T4147 23995-23998 CD denotes two
T4148 23999-24005 JJ denotes mutant
T4149 24023-24028 PRP$ denotes their
T4150 24029-24036 NN denotes ability
T4151 24037-24039 TO denotes to
T4152 24040-24050 VB denotes complement
T4153 24051-24055 DT denotes some
T4154 24056-24066 NNS denotes phenotypes
T4155 24067-24068 -LRB- denotes (
T4156 24068-24072 NN denotes hair
T4157 24072-24073 -RRB- denotes )
T4158 24073-24074 . denotes .
T4159 24074-24237 sentence denotes An overview of the functional relationships between Xpd alleles, phenotypes, and the presumed underlying TFIIH function in mice and cells is presented in Table 2.
T4160 24075-24077 DT denotes An
T4161 24078-24086 NN denotes overview
T4162 24216-24225 VBN denotes presented
T4163 24087-24089 IN denotes of
T4164 24090-24093 DT denotes the
T4165 24105-24118 NNS denotes relationships
T4166 24094-24104 JJ denotes functional
T4167 24119-24126 IN denotes between
T4168 24127-24130 NN denotes Xpd
T4169 24131-24138 NNS denotes alleles
T4170 24138-24140 , denotes ,
T4171 24140-24150 NNS denotes phenotypes
T4172 24150-24152 , denotes ,
T4173 24152-24155 CC denotes and
T4174 24156-24159 DT denotes the
T4175 24186-24194 NN denotes function
T4176 24160-24168 VBN denotes presumed
T4177 24169-24179 VBG denotes underlying
T4178 24180-24185 NN denotes TFIIH
T4179 24195-24197 IN denotes in
T4180 24198-24202 NNS denotes mice
T4181 24203-24206 CC denotes and
T4182 24207-24212 NNS denotes cells
T4183 24213-24215 VBZ denotes is
T4184 24226-24228 IN denotes in
T4185 24229-24234 NN denotes Table
T4186 24235-24236 CD denotes 2
T4187 24236-24237 . denotes .
T4259 24251-24261 NN denotes Dissection
T4260 24262-24264 IN denotes of
T4261 24265-24274 JJ denotes Biallelic
T4262 24275-24282 NNS denotes Effects
T4263 24283-24287 IN denotes from
T4264 24288-24293 JJ denotes other
T4265 24294-24306 NNS denotes Determinants
T4266 24307-24309 IN denotes of
T4267 24310-24319 NN denotes Phenotype
T4268 24319-24611 sentence denotes Although phenotypic consequences, referred to here as biallelic effects, resulting from two different mutant alleles in compound heterozygote patients have been postulated, such effects have historically been difficult to distinguish from the influence of environment and genetic background.
T4269 24320-24328 IN denotes Although
T4270 24481-24491 VBN denotes postulated
T4271 24329-24339 JJ denotes phenotypic
T4272 24340-24352 NNS denotes consequences
T4273 24352-24354 , denotes ,
T4274 24354-24362 VBN denotes referred
T4275 24363-24365 IN denotes to
T4276 24366-24370 RB denotes here
T4277 24371-24373 IN denotes as
T4278 24374-24383 JJ denotes biallelic
T4279 24384-24391 NNS denotes effects
T4280 24391-24393 , denotes ,
T4281 24393-24402 VBG denotes resulting
T4282 24403-24407 IN denotes from
T4283 24408-24411 CD denotes two
T4284 24429-24436 NNS denotes alleles
T4285 24412-24421 JJ denotes different
T4286 24422-24428 JJ denotes mutant
T4287 24437-24439 IN denotes in
T4288 24440-24448 NN denotes compound
T4289 24462-24470 NNS denotes patients
T4290 24449-24461 NN denotes heterozygote
T4291 24471-24475 VBP denotes have
T4292 24476-24480 VBN denotes been
T4293 24524-24528 VBN denotes been
T4294 24491-24493 , denotes ,
T4295 24493-24497 JJ denotes such
T4296 24498-24505 NNS denotes effects
T4297 24506-24510 VBP denotes have
T4298 24511-24523 RB denotes historically
T4299 24529-24538 JJ denotes difficult
T4300 24539-24541 TO denotes to
T4301 24542-24553 VB denotes distinguish
T4302 24554-24558 IN denotes from
T4303 24559-24562 DT denotes the
T4304 24563-24572 NN denotes influence
T4305 24573-24575 IN denotes of
T4306 24576-24587 NN denotes environment
T4307 24588-24591 CC denotes and
T4308 24592-24599 JJ denotes genetic
T4309 24600-24610 NN denotes background
T4310 24610-24611 . denotes .
T4311 24611-24816 sentence denotes We used a genetically defined mammalian model system under controlled environmental conditions to reveal phenotypic effects attributable specifically to combinations of differentially mutated Xpd alleles.
T4312 24612-24614 PRP denotes We
T4313 24615-24619 VBD denotes used
T4314 24620-24621 DT denotes a
T4315 24658-24664 NN denotes system
T4316 24622-24633 RB denotes genetically
T4317 24634-24641 VBN denotes defined
T4318 24642-24651 JJ denotes mammalian
T4319 24652-24657 NN denotes model
T4320 24665-24670 IN denotes under
T4321 24671-24681 JJ denotes controlled
T4322 24696-24706 NNS denotes conditions
T4323 24682-24695 JJ denotes environmental
T4324 24707-24709 TO denotes to
T4325 24710-24716 VB denotes reveal
T4326 24717-24727 JJ denotes phenotypic
T4327 24728-24735 NNS denotes effects
T4328 24736-24748 JJ denotes attributable
T4329 24749-24761 RB denotes specifically
T4330 24762-24764 IN denotes to
T4331 24765-24777 NNS denotes combinations
T4332 24778-24780 IN denotes of
T4333 24781-24795 RB denotes differentially
T4334 24796-24803 VBN denotes mutated
T4335 24808-24815 NNS denotes alleles
T4336 24804-24807 NN denotes Xpd
T4337 24815-24816 . denotes .
T4338 24816-24876 sentence denotes The observed biallelic effects were of three general types.
T4339 24817-24820 DT denotes The
T4340 24840-24847 NNS denotes effects
T4341 24821-24829 VBN denotes observed
T4342 24830-24839 JJ denotes biallelic
T4343 24848-24852 VBD denotes were
T4344 24853-24855 IN denotes of
T4345 24856-24861 CD denotes three
T4346 24870-24875 NNS denotes types
T4347 24862-24869 JJ denotes general
T4348 24875-24876 . denotes .
T4349 24876-25064 sentence denotes In the first, the allele associated in a homozygous state with a phenotype closer to wt singularly determined the phenotypic outcome, a phenomenon widely known in human recessive disease.
T4350 24877-24879 IN denotes In
T4351 24976-24986 VBN denotes determined
T4352 24880-24883 DT denotes the
T4353 24884-24889 JJ denotes first
T4354 24889-24891 , denotes ,
T4355 24891-24894 DT denotes the
T4356 24895-24901 NN denotes allele
T4357 24902-24912 VBN denotes associated
T4358 24913-24915 IN denotes in
T4359 24916-24917 DT denotes a
T4360 24929-24934 NN denotes state
T4361 24918-24928 JJ denotes homozygous
T4362 24935-24939 IN denotes with
T4363 24940-24941 DT denotes a
T4364 24942-24951 NN denotes phenotype
T4365 24952-24958 RBR denotes closer
T4366 24959-24961 IN denotes to
T4367 24962-24964 NN denotes wt
T4368 24965-24975 RB denotes singularly
T4369 24987-24990 DT denotes the
T4370 25002-25009 NN denotes outcome
T4371 24991-25001 JJ denotes phenotypic
T4372 25009-25011 , denotes ,
T4373 25011-25012 DT denotes a
T4374 25013-25023 NN denotes phenomenon
T4375 25024-25030 RB denotes widely
T4376 25031-25036 VBN denotes known
T4377 25037-25039 IN denotes in
T4378 25040-25045 JJ denotes human
T4379 25056-25063 NN denotes disease
T4380 25046-25055 JJ denotes recessive
T4381 25063-25064 . denotes .
T4382 25064-25195 sentence denotes Because these Xpd alleles functioned at or near wt levels with respect to a particular function, we call these effects “dominant”.
T4383 25065-25072 IN denotes Because
T4384 25091-25101 VBD denotes functioned
T4385 25073-25078 DT denotes these
T4386 25083-25090 NNS denotes alleles
T4387 25079-25082 NN denotes Xpd
T4388 25165-25169 VBP denotes call
T4389 25102-25104 IN denotes at
T4390 25105-25107 CC denotes or
T4391 25108-25112 IN denotes near
T4392 25113-25115 NN denotes wt
T4393 25116-25122 NNS denotes levels
T4394 25123-25127 IN denotes with
T4395 25128-25135 NN denotes respect
T4396 25136-25138 IN denotes to
T4397 25139-25140 DT denotes a
T4398 25152-25160 NN denotes function
T4399 25141-25151 JJ denotes particular
T4400 25160-25162 , denotes ,
T4401 25162-25164 PRP denotes we
T4402 25170-25175 DT denotes these
T4403 25176-25183 NNS denotes effects
T4404 25184-25185 `` denotes “
T4405 25185-25193 JJ denotes dominant
T4406 25193-25194 '' denotes ”
T4407 25194-25195 . denotes .
T4408 25195-25364 sentence denotes Such alleles can also be referred to as “separation of function” alleles, because they allow dissection of the roles of multifunctional proteins in specific phenotypes.
T4409 25196-25200 JJ denotes Such
T4410 25201-25208 NNS denotes alleles
T4411 25221-25229 VBN denotes referred
T4412 25209-25212 MD denotes can
T4413 25213-25217 RB denotes also
T4414 25218-25220 VB denotes be
T4415 25230-25232 IN denotes to
T4416 25233-25235 IN denotes as
T4417 25236-25237 `` denotes “
T4418 25261-25268 NNS denotes alleles
T4419 25237-25247 NN denotes separation
T4420 25248-25250 IN denotes of
T4421 25251-25259 NN denotes function
T4422 25259-25260 '' denotes ”
T4423 25268-25270 , denotes ,
T4424 25270-25277 IN denotes because
T4425 25283-25288 VBP denotes allow
T4426 25278-25282 PRP denotes they
T4427 25289-25299 NN denotes dissection
T4428 25300-25302 IN denotes of
T4429 25303-25306 DT denotes the
T4430 25307-25312 NNS denotes roles
T4431 25313-25315 IN denotes of
T4432 25316-25331 JJ denotes multifunctional
T4433 25332-25340 NN denotes proteins
T4434 25341-25343 IN denotes in
T4435 25344-25352 JJ denotes specific
T4436 25353-25363 NNS denotes phenotypes
T4437 25363-25364 . denotes .
T4438 25364-25741 sentence denotes Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from A dominant |a recessive to A recessive |a dominant with respect to different phenotypes in a time-dependent and tissue-specific manner (see below and Table 2).
T4439 25365-25373 RB denotes Secondly
T4440 25474-25477 VBD denotes was
T4441 25373-25375 , denotes ,
T4442 25375-25387 VBG denotes highlighting
T4443 25388-25391 DT denotes the
T4444 25402-25411 NN denotes relevance
T4445 25392-25401 JJ denotes potential
T4446 25412-25414 IN denotes of
T4447 25415-25422 JJ denotes current
T4448 25423-25431 NNS denotes findings
T4449 25432-25434 IN denotes to
T4450 25435-25438 DT denotes all
T4451 25447-25456 NNS denotes organisms
T4452 25439-25446 JJ denotes diploid
T4453 25457-25466 VBG denotes including
T4454 25467-25473 NNS denotes humans
T4455 25478-25481 DT denotes the
T4456 25482-25493 NN denotes observation
T4457 25494-25498 IN denotes that
T4458 25571-25576 VB denotes shift
T4459 25499-25501 IN denotes in
T4460 25502-25505 CD denotes one
T4461 25528-25534 NN denotes animal
T4462 25506-25514 NN denotes compound
T4463 25515-25527 JJ denotes heterozygous
T4464 25534-25536 , denotes ,
T4465 25536-25539 DT denotes the
T4466 25552-25564 NN denotes relationship
T4467 25540-25543 NN denotes Xpd
T4468 25544-25551 JJ denotes allelic
T4469 25565-25570 MD denotes could
T4470 25577-25581 IN denotes from
T4471 25582-25592 JJ denotes A dominant
T4472 25594-25605 JJ denotes a recessive
T4473 25593-25594 HYPH denotes |
T4474 25606-25608 IN denotes to
T4475 25609-25620 JJ denotes A recessive
T4476 25622-25632 JJ denotes a dominant
T4477 25621-25622 HYPH denotes |
T4478 25633-25637 IN denotes with
T4479 25638-25645 NN denotes respect
T4480 25646-25648 IN denotes to
T4481 25649-25658 JJ denotes different
T4482 25659-25669 NNS denotes phenotypes
T4483 25670-25672 IN denotes in
T4484 25673-25674 DT denotes a
T4485 25710-25716 NN denotes manner
T4486 25675-25679 NN denotes time
T4487 25680-25689 JJ denotes dependent
T4488 25679-25680 HYPH denotes -
T4489 25690-25693 CC denotes and
T4490 25694-25700 NN denotes tissue
T4491 25701-25709 JJ denotes specific
T4492 25700-25701 HYPH denotes -
T4493 25717-25718 -LRB- denotes (
T4494 25718-25721 VB denotes see
T4495 25722-25727 RB denotes below
T4496 25732-25737 NN denotes Table
T4497 25728-25731 CC denotes and
T4498 25738-25739 CD denotes 2
T4499 25739-25740 -RRB- denotes )
T4500 25740-25741 . denotes .
T4501 25741-25928 sentence denotes In the third type of biallelic effect, known as interallelic complementation, two mutant alleles produced a phenotype closer to wt than either could alone in a homo- or hemizygous state.
T4502 25742-25744 IN denotes In
T4503 25839-25847 VBD denotes produced
T4504 25745-25748 DT denotes the
T4505 25755-25759 NN denotes type
T4506 25749-25754 JJ denotes third
T4507 25760-25762 IN denotes of
T4508 25763-25772 JJ denotes biallelic
T4509 25773-25779 NN denotes effect
T4510 25779-25781 , denotes ,
T4511 25781-25786 VBN denotes known
T4512 25787-25789 IN denotes as
T4513 25790-25802 JJ denotes interallelic
T4514 25803-25818 NN denotes complementation
T4515 25818-25820 , denotes ,
T4516 25820-25823 CD denotes two
T4517 25831-25838 NNS denotes alleles
T4518 25824-25830 JJ denotes mutant
T4519 25848-25849 DT denotes a
T4520 25850-25859 NN denotes phenotype
T4521 25860-25866 RBR denotes closer
T4522 25867-25869 IN denotes to
T4523 25870-25872 NN denotes wt
T4524 25873-25877 IN denotes than
T4525 25891-25896 RB denotes alone
T4526 25878-25884 DT denotes either
T4527 25885-25890 MD denotes could
T4528 25897-25899 IN denotes in
T4529 25900-25901 DT denotes a
T4530 25922-25927 NN denotes state
T4531 25902-25906 AFX denotes homo
T4532 25911-25921 JJ denotes hemizygous
T4533 25906-25907 HYPH denotes -
T4534 25908-25910 CC denotes or
T4535 25927-25928 . denotes .
T4536 25928-26103 sentence denotes As summarised in Table 2, examples of all types of biallelic effects were observed in a variety of Xpd-associated phenotypes, ranging from brittle hair to segmental progeria.
T4537 25929-25931 IN denotes As
T4538 25932-25942 VBN denotes summarised
T4539 26003-26011 VBN denotes observed
T4540 25943-25945 IN denotes in
T4541 25946-25951 NN denotes Table
T4542 25952-25953 CD denotes 2
T4543 25953-25955 , denotes ,
T4544 25955-25963 NNS denotes examples
T4545 25964-25966 IN denotes of
T4546 25967-25970 DT denotes all
T4547 25971-25976 NNS denotes types
T4548 25977-25979 IN denotes of
T4549 25980-25989 JJ denotes biallelic
T4550 25990-25997 NNS denotes effects
T4551 25998-26002 VBD denotes were
T4552 26012-26014 IN denotes in
T4553 26015-26016 DT denotes a
T4554 26017-26024 NN denotes variety
T4555 26025-26027 IN denotes of
T4556 26028-26031 NN denotes Xpd
T4557 26032-26042 VBN denotes associated
T4558 26031-26032 HYPH denotes -
T4559 26043-26053 NNS denotes phenotypes
T4560 26053-26055 , denotes ,
T4561 26055-26062 VBG denotes ranging
T4562 26063-26067 IN denotes from
T4563 26068-26075 JJ denotes brittle
T4564 26076-26080 NN denotes hair
T4565 26081-26083 IN denotes to
T4566 26084-26093 JJ denotes segmental
T4567 26094-26102 NN denotes progeria
T4568 26102-26103 . denotes .
T4805 26105-26110 NN denotes TFIIH
T4806 26111-26113 IN denotes in
T4807 26114-26127 NN denotes Transcription
T4808 26128-26131 CC denotes and
T4809 26132-26138 NN denotes Repair
T4810 26138-26140 : denotes :
T4811 26140-26150 NNS denotes Mechanisms
T4812 26151-26153 IN denotes of
T4813 26154-26157 NN denotes XPD
T4814 26166-26176 NN denotes Pleiotropy
T4815 26158-26165 NN denotes Disease
T4816 26176-26466 sentence denotes We observed differences in the ability of XpdTTD versus homozygous lethal Xpd†XPCS and Xpd†XP alleles to function in two transcription-related phenotypes separated in the organism by both time and space: embryonic lethality and terminal differentiation of enucleating skin and blood cells.
T4817 26177-26179 PRP denotes We
T4818 26180-26188 VBD denotes observed
T4819 26189-26200 NNS denotes differences
T4820 26201-26203 IN denotes in
T4821 26204-26207 DT denotes the
T4822 26208-26215 NN denotes ability
T4823 26216-26218 IN denotes of
T4824 26219-26225 NN denotes XpdTTD
T4825 26226-26232 CC denotes versus
T4826 26233-26243 JJ denotes homozygous
T4827 26271-26278 NNS denotes alleles
T4828 26244-26250 JJ denotes lethal
T4829 26251-26259 NN denotes Xpd†XPCS
T4830 26260-26263 CC denotes and
T4831 26264-26270 NN denotes Xpd†XP
T4832 26279-26281 TO denotes to
T4833 26282-26290 VB denotes function
T4834 26291-26293 IN denotes in
T4835 26294-26297 CD denotes two
T4836 26320-26330 NNS denotes phenotypes
T4837 26298-26311 NN denotes transcription
T4838 26312-26319 VBN denotes related
T4839 26311-26312 HYPH denotes -
T4840 26331-26340 VBN denotes separated
T4841 26341-26343 IN denotes in
T4842 26344-26347 DT denotes the
T4843 26348-26356 NN denotes organism
T4844 26357-26359 IN denotes by
T4845 26360-26364 CC denotes both
T4846 26365-26369 NN denotes time
T4847 26370-26373 CC denotes and
T4848 26374-26379 NN denotes space
T4849 26379-26381 : denotes :
T4850 26381-26390 JJ denotes embryonic
T4851 26391-26400 NN denotes lethality
T4852 26401-26404 CC denotes and
T4853 26405-26413 JJ denotes terminal
T4854 26414-26429 NN denotes differentiation
T4855 26430-26432 IN denotes of
T4856 26433-26444 VBG denotes enucleating
T4857 26445-26449 NN denotes skin
T4858 26450-26453 CC denotes and
T4859 26454-26459 NN denotes blood
T4860 26460-26465 NNS denotes cells
T4861 26465-26466 . denotes .
T4862 26466-26646 sentence denotes The preblastocyst-stage homozygous lethality shared by the XpdKO, Xpd†XPCS, and Xpd†XP alleles most likely reflects a defect in basal transcription that is incompatible with life.
T4863 26467-26470 DT denotes The
T4864 26502-26511 NN denotes lethality
T4865 26471-26484 NN denotes preblastocyst
T4866 26485-26490 NN denotes stage
T4867 26484-26485 HYPH denotes -
T4868 26491-26501 JJ denotes homozygous
T4869 26574-26582 VBZ denotes reflects
T4870 26512-26518 VBN denotes shared
T4871 26519-26521 IN denotes by
T4872 26522-26525 DT denotes the
T4873 26554-26561 NNS denotes alleles
T4874 26526-26531 NN denotes XpdKO
T4875 26531-26533 , denotes ,
T4876 26533-26541 NN denotes Xpd†XPCS
T4877 26541-26543 , denotes ,
T4878 26543-26546 CC denotes and
T4879 26547-26553 NN denotes Xpd†XP
T4880 26562-26566 RBS denotes most
T4881 26567-26573 RB denotes likely
T4882 26583-26584 DT denotes a
T4883 26585-26591 NN denotes defect
T4884 26592-26594 IN denotes in
T4885 26595-26600 JJ denotes basal
T4886 26601-26614 NN denotes transcription
T4887 26615-26619 WDT denotes that
T4888 26620-26622 VBZ denotes is
T4889 26623-26635 JJ denotes incompatible
T4890 26636-26640 IN denotes with
T4891 26641-26645 NN denotes life
T4892 26645-26646 . denotes .
T4893 26646-26767 sentence denotes In XpdTTD/ †XPCS and XpdTTD/ †XP compound heterozygous mice, embryonic lethality was fully rescued by the XpdTTD allele.
T4894 26647-26649 IN denotes In
T4895 26738-26745 VBN denotes rescued
T4896 26650-26656 NN denotes XpdTTD
T4897 26657-26663 NN denotes  †XPCS
T4898 26656-26657 HYPH denotes /
T4899 26702-26706 NNS denotes mice
T4900 26664-26667 CC denotes and
T4901 26668-26674 NN denotes XpdTTD
T4902 26675-26679 NN denotes  †XP
T4903 26674-26675 HYPH denotes /
T4904 26680-26688 NN denotes compound
T4905 26689-26701 JJ denotes heterozygous
T4906 26706-26708 , denotes ,
T4907 26708-26717 JJ denotes embryonic
T4908 26718-26727 NN denotes lethality
T4909 26728-26731 VBD denotes was
T4910 26732-26737 RB denotes fully
T4911 26746-26748 IN denotes by
T4912 26749-26752 DT denotes the
T4913 26760-26766 NN denotes allele
T4914 26753-26759 NN denotes XpdTTD
T4915 26766-26767 . denotes .
T4916 26767-27032 sentence denotes Because embryonic lethality was also fully rescued in XpdTTD/KO hemizygous mice, the XpdTTD allele can be considered as wt and thus dominant to each of the homozygous lethal alleles (XpdKO, Xpd†XPCS, and Xpd†XP) with respect to this particular phenotype (Table 2).
T4917 26768-26775 IN denotes Because
T4918 26811-26818 VBN denotes rescued
T4919 26776-26785 JJ denotes embryonic
T4920 26786-26795 NN denotes lethality
T4921 26796-26799 VBD denotes was
T4922 26800-26804 RB denotes also
T4923 26805-26810 RB denotes fully
T4924 26874-26884 VBN denotes considered
T4925 26819-26821 IN denotes in
T4926 26822-26828 NN denotes XpdTTD
T4927 26829-26831 NN denotes KO
T4928 26828-26829 HYPH denotes /
T4929 26843-26847 NNS denotes mice
T4930 26832-26842 JJ denotes hemizygous
T4931 26847-26849 , denotes ,
T4932 26849-26852 DT denotes the
T4933 26860-26866 NN denotes allele
T4934 26853-26859 NN denotes XpdTTD
T4935 26867-26870 MD denotes can
T4936 26871-26873 VB denotes be
T4937 26885-26887 IN denotes as
T4938 26888-26890 NN denotes wt
T4939 26891-26894 CC denotes and
T4940 26895-26899 RB denotes thus
T4941 26900-26908 JJ denotes dominant
T4942 26909-26911 IN denotes to
T4943 26912-26916 DT denotes each
T4944 26917-26919 IN denotes of
T4945 26920-26923 DT denotes the
T4946 26942-26949 NNS denotes alleles
T4947 26924-26934 JJ denotes homozygous
T4948 26935-26941 JJ denotes lethal
T4949 26950-26951 -LRB- denotes (
T4950 26951-26956 NN denotes XpdKO
T4951 26956-26958 , denotes ,
T4952 26958-26966 NN denotes Xpd†XPCS
T4953 26966-26968 , denotes ,
T4954 26968-26971 CC denotes and
T4955 26972-26978 NN denotes Xpd†XP
T4956 26978-26979 -RRB- denotes )
T4957 26980-26984 IN denotes with
T4958 26985-26992 NN denotes respect
T4959 26993-26995 IN denotes to
T4960 26996-27000 DT denotes this
T4961 27012-27021 NN denotes phenotype
T4962 27001-27011 JJ denotes particular
T4963 27022-27023 -LRB- denotes (
T4964 27023-27028 NN denotes Table
T4965 27029-27030 CD denotes 2
T4966 27030-27031 -RRB- denotes )
T4967 27031-27032 . denotes .
T4968 27032-27292 sentence denotes TTD-specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind of transcriptional insufficiency caused by depletion of unstable TFIIH during the terminal differentiation of skin, hair-shaft, and blood cells [16,24].
T4969 27033-27036 NN denotes TTD
T4970 27037-27045 JJ denotes specific
T4971 27036-27037 HYPH denotes -
T4972 27068-27076 NNS denotes features
T4973 27046-27055 JJ denotes cutaneous
T4974 27056-27059 CC denotes and
T4975 27060-27067 JJ denotes anaemic
T4976 27101-27108 VBN denotes thought
T4977 27076-27078 , denotes ,
T4978 27078-27080 IN denotes on
T4979 27081-27084 DT denotes the
T4980 27091-27095 NN denotes hand
T4981 27085-27090 JJ denotes other
T4982 27095-27097 , denotes ,
T4983 27097-27100 VBP denotes are
T4984 27109-27111 TO denotes to
T4985 27112-27118 VB denotes result
T4986 27119-27123 IN denotes from
T4987 27124-27125 DT denotes a
T4988 27135-27139 NN denotes kind
T4989 27126-27134 JJ denotes specific
T4990 27140-27142 IN denotes of
T4991 27143-27158 JJ denotes transcriptional
T4992 27159-27172 NN denotes insufficiency
T4993 27173-27179 VBN denotes caused
T4994 27180-27182 IN denotes by
T4995 27183-27192 NN denotes depletion
T4996 27193-27195 IN denotes of
T4997 27196-27204 JJ denotes unstable
T4998 27205-27210 NN denotes TFIIH
T4999 27211-27217 IN denotes during
T5000 27218-27221 DT denotes the
T5001 27231-27246 NN denotes differentiation
T5002 27222-27230 JJ denotes terminal
T5003 27247-27249 IN denotes of
T5004 27250-27254 NN denotes skin
T5005 27278-27283 NNS denotes cells
T5006 27254-27256 , denotes ,
T5007 27256-27260 NN denotes hair
T5008 27261-27266 NN denotes shaft
T5009 27260-27261 HYPH denotes -
T5010 27266-27268 , denotes ,
T5011 27268-27271 CC denotes and
T5012 27272-27277 NN denotes blood
T5013 27284-27285 -LRB- denotes [
T5014 27288-27290 CD denotes 24
T5015 27285-27287 CD denotes 16
T5016 27287-27288 , denotes ,
T5017 27290-27291 -RRB- denotes ]
T5018 27291-27292 . denotes .
T5019 27292-27537 sentence denotes In compound heterozygous mice, both homozygous lethal Xpd†XPCS and Xpd†XP alleles were able to alleviate XpdTTD-specific cutaneous and anaemic features and can thus be defined as dominant over the XpdTTD allele with respect to these phenotypes.
T5020 27293-27295 IN denotes In
T5021 27375-27379 VBD denotes were
T5022 27296-27304 NN denotes compound
T5023 27318-27322 NNS denotes mice
T5024 27305-27317 JJ denotes heterozygous
T5025 27322-27324 , denotes ,
T5026 27324-27328 DT denotes both
T5027 27367-27374 NNS denotes alleles
T5028 27329-27339 JJ denotes homozygous
T5029 27340-27346 JJ denotes lethal
T5030 27347-27355 NN denotes Xpd†XPCS
T5031 27356-27359 CC denotes and
T5032 27360-27366 NN denotes Xpd†XP
T5033 27380-27384 JJ denotes able
T5034 27385-27387 TO denotes to
T5035 27388-27397 VB denotes alleviate
T5036 27398-27404 NN denotes XpdTTD
T5037 27405-27413 JJ denotes specific
T5038 27404-27405 HYPH denotes -
T5039 27436-27444 NNS denotes features
T5040 27414-27423 JJ denotes cutaneous
T5041 27424-27427 CC denotes and
T5042 27428-27435 JJ denotes anaemic
T5043 27445-27448 CC denotes and
T5044 27449-27452 MD denotes can
T5045 27461-27468 VBN denotes defined
T5046 27453-27457 RB denotes thus
T5047 27458-27460 VB denotes be
T5048 27469-27471 IN denotes as
T5049 27472-27480 JJ denotes dominant
T5050 27481-27485 IN denotes over
T5051 27486-27489 DT denotes the
T5052 27497-27503 NN denotes allele
T5053 27490-27496 NN denotes XpdTTD
T5054 27504-27508 IN denotes with
T5055 27509-27516 NN denotes respect
T5056 27517-27519 IN denotes to
T5057 27520-27525 DT denotes these
T5058 27526-27536 NNS denotes phenotypes
T5059 27536-27537 . denotes .
T5060 27537-27754 sentence denotes We conclude that the defects leading to embryonic lethality and aberrant terminal differentiation of the skin, hair, and blood represent two qualitatively and/or quantitatively different transcriptional deficiencies.
T5061 27538-27540 PRP denotes We
T5062 27541-27549 VBP denotes conclude
T5063 27550-27554 IN denotes that
T5064 27665-27674 VBP denotes represent
T5065 27555-27558 DT denotes the
T5066 27559-27566 NNS denotes defects
T5067 27567-27574 VBG denotes leading
T5068 27575-27577 IN denotes to
T5069 27578-27587 JJ denotes embryonic
T5070 27588-27597 NN denotes lethality
T5071 27598-27601 CC denotes and
T5072 27602-27610 JJ denotes aberrant
T5073 27620-27635 NN denotes differentiation
T5074 27611-27619 JJ denotes terminal
T5075 27636-27638 IN denotes of
T5076 27639-27642 DT denotes the
T5077 27643-27647 NN denotes skin
T5078 27647-27649 , denotes ,
T5079 27649-27653 NN denotes hair
T5080 27653-27655 , denotes ,
T5081 27655-27658 CC denotes and
T5082 27659-27664 NN denotes blood
T5083 27675-27678 CD denotes two
T5084 27741-27753 NNS denotes deficiencies
T5085 27679-27692 RB denotes qualitatively
T5086 27715-27724 JJ denotes different
T5087 27693-27696 CC denotes and
T5088 27696-27697 HYPH denotes /
T5089 27697-27699 CC denotes or
T5090 27700-27714 RB denotes quantitatively
T5091 27725-27740 JJ denotes transcriptional
T5092 27753-27754 . denotes .
T5093 27754-27945 sentence denotes During early embryonic development, XpdTTD is dominant over the Xpd†XPCS and Xpd†XP alleles, whereas later in the ontogenesis of skin, hair-shaft, and blood cells, the situation is reversed.
T5094 27755-27761 IN denotes During
T5095 27798-27800 VBZ denotes is
T5096 27762-27767 JJ denotes early
T5097 27778-27789 NN denotes development
T5098 27768-27777 JJ denotes embryonic
T5099 27789-27791 , denotes ,
T5100 27791-27797 NN denotes XpdTTD
T5101 27801-27809 JJ denotes dominant
T5102 27810-27814 IN denotes over
T5103 27815-27818 DT denotes the
T5104 27839-27846 NNS denotes alleles
T5105 27819-27827 NN denotes Xpd†XPCS
T5106 27828-27831 CC denotes and
T5107 27832-27838 NN denotes Xpd†XP
T5108 27846-27848 , denotes ,
T5109 27848-27855 IN denotes whereas
T5110 27936-27944 VBN denotes reversed
T5111 27856-27861 RB denotes later
T5112 27862-27864 IN denotes in
T5113 27865-27868 DT denotes the
T5114 27869-27880 NN denotes ontogenesis
T5115 27881-27883 IN denotes of
T5116 27884-27888 NN denotes skin
T5117 27888-27890 , denotes ,
T5118 27890-27894 NN denotes hair
T5119 27895-27900 NN denotes shaft
T5120 27894-27895 HYPH denotes -
T5121 27900-27902 , denotes ,
T5122 27902-27905 CC denotes and
T5123 27906-27911 NN denotes blood
T5124 27912-27917 NNS denotes cells
T5125 27917-27919 , denotes ,
T5126 27919-27922 DT denotes the
T5127 27923-27932 NN denotes situation
T5128 27933-27935 VBZ denotes is
T5129 27944-27945 . denotes .
T5130 27945-28188 sentence denotes In its role in the repair of UV photolesions, the Xpd†XPCS allele imparted a clear UV survival benefit over a single XpdTTD allele or two XpdXPCS alleles independent of expression levels, which is consistent with interallelic complementation.
T5131 27946-27948 IN denotes In
T5132 28012-28020 VBD denotes imparted
T5133 27949-27952 PRP$ denotes its
T5134 27953-27957 NN denotes role
T5135 27958-27960 IN denotes in
T5136 27961-27964 DT denotes the
T5137 27965-27971 NN denotes repair
T5138 27972-27974 IN denotes of
T5139 27975-27977 NN denotes UV
T5140 27978-27990 NNS denotes photolesions
T5141 27990-27992 , denotes ,
T5142 27992-27995 DT denotes the
T5143 28005-28011 NN denotes allele
T5144 27996-28004 NN denotes Xpd†XPCS
T5145 28021-28022 DT denotes a
T5146 28041-28048 NN denotes benefit
T5147 28023-28028 JJ denotes clear
T5148 28029-28031 NN denotes UV
T5149 28032-28040 NN denotes survival
T5150 28049-28053 IN denotes over
T5151 28054-28055 DT denotes a
T5152 28070-28076 NN denotes allele
T5153 28056-28062 JJ denotes single
T5154 28063-28069 NN denotes XpdTTD
T5155 28077-28079 CC denotes or
T5156 28080-28083 CD denotes two
T5157 28092-28099 NNS denotes alleles
T5158 28084-28091 NN denotes XpdXPCS
T5159 28100-28111 JJ denotes independent
T5160 28112-28114 IN denotes of
T5161 28115-28125 NN denotes expression
T5162 28126-28132 NNS denotes levels
T5163 28132-28134 , denotes ,
T5164 28134-28139 WDT denotes which
T5165 28140-28142 VBZ denotes is
T5166 28143-28153 JJ denotes consistent
T5167 28154-28158 IN denotes with
T5168 28159-28171 JJ denotes interallelic
T5169 28172-28187 NN denotes complementation
T5170 28187-28188 . denotes .
T5171 28188-28408 sentence denotes However, the observation that no other cellular or biochemical UV-related parameters were improved in XpdTTD/ †XPCS argues against complementation of this repair activity in the rescue of TTD progeroid symptoms in vivo.
T5172 28189-28196 RB denotes However
T5173 28305-28311 VBZ denotes argues
T5174 28196-28198 , denotes ,
T5175 28198-28201 DT denotes the
T5176 28202-28213 NN denotes observation
T5177 28214-28218 IN denotes that
T5178 28279-28287 VBN denotes improved
T5179 28219-28221 DT denotes no
T5180 28263-28273 NNS denotes parameters
T5181 28222-28227 JJ denotes other
T5182 28228-28236 JJ denotes cellular
T5183 28237-28239 CC denotes or
T5184 28240-28251 JJ denotes biochemical
T5185 28252-28254 NN denotes UV
T5186 28255-28262 VBN denotes related
T5187 28254-28255 HYPH denotes -
T5188 28274-28278 VBD denotes were
T5189 28288-28290 IN denotes in
T5190 28291-28297 NN denotes XpdTTD
T5191 28298-28304 NN denotes  †XPCS
T5192 28297-28298 HYPH denotes /
T5193 28312-28319 IN denotes against
T5194 28320-28335 NN denotes complementation
T5195 28336-28338 IN denotes of
T5196 28339-28343 DT denotes this
T5197 28351-28359 NN denotes activity
T5198 28344-28350 NN denotes repair
T5199 28360-28362 IN denotes in
T5200 28363-28366 DT denotes the
T5201 28367-28373 NN denotes rescue
T5202 28374-28376 IN denotes of
T5203 28377-28380 NN denotes TTD
T5204 28391-28399 NNS denotes symptoms
T5205 28381-28390 JJ denotes progeroid
T5206 28400-28402 FW denotes in
T5207 28403-28407 FW denotes vivo
T5208 28407-28408 . denotes .
T5295 28410-28422 JJ denotes Interallelic
T5296 28423-28438 NN denotes Complementation
T5297 28439-28442 CC denotes and
T5298 28443-28446 NN denotes XPD
T5299 28447-28455 NN denotes Function
T5300 28455-28539 sentence denotes What does interallelic complementation tell us about the mechanism of XPD function?
T5301 28456-28460 WP denotes What
T5302 28495-28499 VB denotes tell
T5303 28461-28465 VBZ denotes does
T5304 28466-28478 JJ denotes interallelic
T5305 28479-28494 NN denotes complementation
T5306 28500-28502 PRP denotes us
T5307 28503-28508 IN denotes about
T5308 28509-28512 DT denotes the
T5309 28513-28522 NN denotes mechanism
T5310 28523-28525 IN denotes of
T5311 28526-28529 NN denotes XPD
T5312 28530-28538 NN denotes function
T5313 28538-28539 . denotes ?
T5314 28539-28648 sentence denotes Interallelic complementation is most often observed in multimeric proteins with multiple functional domains.
T5315 28540-28552 JJ denotes Interallelic
T5316 28553-28568 NN denotes complementation
T5317 28583-28591 VBN denotes observed
T5318 28569-28571 VBZ denotes is
T5319 28572-28576 RBS denotes most
T5320 28577-28582 RB denotes often
T5321 28592-28594 IN denotes in
T5322 28595-28605 JJ denotes multimeric
T5323 28606-28614 NN denotes proteins
T5324 28615-28619 IN denotes with
T5325 28620-28628 JJ denotes multiple
T5326 28640-28647 NNS denotes domains
T5327 28629-28639 JJ denotes functional
T5328 28647-28648 . denotes .
T5329 28648-28867 sentence denotes Unfortunately, the structure–function relationship between disease-causing mutations and XPD functional domains, including detailed structural information on XPD or even its stoichiometry within TFIIH, remains unknown.
T5330 28649-28662 RB denotes Unfortunately
T5331 28851-28858 VBZ denotes remains
T5332 28662-28664 , denotes ,
T5333 28664-28667 DT denotes the
T5334 28687-28699 NN denotes relationship
T5335 28668-28677 NN denotes structure
T5336 28678-28686 NN denotes function
T5337 28677-28678 HYPH denotes –
T5338 28700-28707 IN denotes between
T5339 28708-28715 NN denotes disease
T5340 28716-28723 VBG denotes causing
T5341 28715-28716 HYPH denotes -
T5342 28724-28733 NNS denotes mutations
T5343 28734-28737 CC denotes and
T5344 28738-28741 NN denotes XPD
T5345 28753-28760 NNS denotes domains
T5346 28742-28752 JJ denotes functional
T5347 28760-28762 , denotes ,
T5348 28762-28771 VBG denotes including
T5349 28772-28780 JJ denotes detailed
T5350 28792-28803 NN denotes information
T5351 28781-28791 JJ denotes structural
T5352 28804-28806 IN denotes on
T5353 28807-28810 NN denotes XPD
T5354 28811-28813 CC denotes or
T5355 28814-28818 RB denotes even
T5356 28823-28836 NN denotes stoichiometry
T5357 28819-28822 PRP$ denotes its
T5358 28837-28843 IN denotes within
T5359 28844-28849 NN denotes TFIIH
T5360 28849-28851 , denotes ,
T5361 28859-28866 JJ denotes unknown
T5362 28866-28867 . denotes .
T5363 28867-29136 sentence denotes However, based on the ability of cell extracts that are defective in two different TFIIH components (XPD and XPB) to complement NER activity in vitro [26], it is likely that TFIIH (or its components) can either multimerise or exchange at least during the NER reaction.
T5364 28868-28875 RB denotes However
T5365 29027-29029 VBZ denotes is
T5366 28875-28877 , denotes ,
T5367 28877-28882 VBN denotes based
T5368 28883-28885 IN denotes on
T5369 28886-28889 DT denotes the
T5370 28890-28897 NN denotes ability
T5371 28898-28900 IN denotes of
T5372 28901-28905 NN denotes cell
T5373 28906-28914 NNS denotes extracts
T5374 28915-28919 WDT denotes that
T5375 28920-28923 VBP denotes are
T5376 28924-28933 JJ denotes defective
T5377 28934-28936 IN denotes in
T5378 28937-28940 CD denotes two
T5379 28957-28967 NNS denotes components
T5380 28941-28950 JJ denotes different
T5381 28951-28956 NN denotes TFIIH
T5382 28968-28969 -LRB- denotes (
T5383 28969-28972 NN denotes XPD
T5384 28973-28976 CC denotes and
T5385 28977-28980 NN denotes XPB
T5386 28980-28981 -RRB- denotes )
T5387 28982-28984 TO denotes to
T5388 28985-28995 VB denotes complement
T5389 28996-28999 NN denotes NER
T5390 29000-29008 NN denotes activity
T5391 29009-29011 FW denotes in
T5392 29012-29017 FW denotes vitro
T5393 29018-29019 -LRB- denotes [
T5394 29019-29021 CD denotes 26
T5395 29021-29022 -RRB- denotes ]
T5396 29022-29024 , denotes ,
T5397 29024-29026 PRP denotes it
T5398 29030-29036 JJ denotes likely
T5399 29037-29041 IN denotes that
T5400 29079-29090 VB denotes multimerise
T5401 29042-29047 NN denotes TFIIH
T5402 29048-29049 -LRB- denotes (
T5403 29049-29051 CC denotes or
T5404 29052-29055 PRP$ denotes its
T5405 29056-29066 NNS denotes components
T5406 29066-29067 -RRB- denotes )
T5407 29068-29071 MD denotes can
T5408 29072-29078 CC denotes either
T5409 29091-29093 CC denotes or
T5410 29094-29102 VB denotes exchange
T5411 29103-29105 RB denotes at
T5412 29106-29111 RBS denotes least
T5413 29112-29118 IN denotes during
T5414 29119-29122 DT denotes the
T5415 29127-29135 NN denotes reaction
T5416 29123-29126 NN denotes NER
T5417 29135-29136 . denotes .
T5418 29136-29209 sentence denotes Furthermore, XPD is known to be a “loosely bound” subunit of TFIIH [27].
T5419 29137-29148 RB denotes Furthermore
T5420 29157-29162 VBN denotes known
T5421 29148-29150 , denotes ,
T5422 29150-29153 NN denotes XPD
T5423 29154-29156 VBZ denotes is
T5424 29163-29165 TO denotes to
T5425 29166-29168 VB denotes be
T5426 29169-29170 DT denotes a
T5427 29187-29194 NN denotes subunit
T5428 29171-29172 RB denotes “
T5429 29172-29179 RB denotes loosely
T5430 29180-29185 VBN denotes bound
T5431 29185-29186 '' denotes ”
T5432 29195-29197 IN denotes of
T5433 29198-29203 NN denotes TFIIH
T5434 29204-29205 -LRB- denotes [
T5435 29205-29207 CD denotes 27
T5436 29207-29208 -RRB- denotes ]
T5437 29208-29209 . denotes .
T5438 29209-29566 sentence denotes We thus envisage the molecular mechanism of interallelic complementation to involve the exchange of XPD molecules within the TFIIH complex or turnover of TFIIH complexes containing different XPD molecules at the site of DNA damage during the course of the global genome as well as transcription-coupled repair of either UV-induced or endogenous DNA damage.
T5439 29210-29212 PRP denotes We
T5440 29218-29226 VBP denotes envisage
T5441 29213-29217 RB denotes thus
T5442 29227-29230 DT denotes the
T5443 29241-29250 NN denotes mechanism
T5444 29231-29240 JJ denotes molecular
T5445 29286-29293 VB denotes involve
T5446 29251-29253 IN denotes of
T5447 29254-29266 JJ denotes interallelic
T5448 29267-29282 NN denotes complementation
T5449 29283-29285 TO denotes to
T5450 29294-29297 DT denotes the
T5451 29298-29306 NN denotes exchange
T5452 29307-29309 IN denotes of
T5453 29310-29313 NN denotes XPD
T5454 29314-29323 NNS denotes molecules
T5455 29324-29330 IN denotes within
T5456 29331-29334 DT denotes the
T5457 29341-29348 NN denotes complex
T5458 29335-29340 NN denotes TFIIH
T5459 29349-29351 CC denotes or
T5460 29352-29360 NN denotes turnover
T5461 29361-29363 IN denotes of
T5462 29364-29369 NN denotes TFIIH
T5463 29370-29379 NNS denotes complexes
T5464 29380-29390 VBG denotes containing
T5465 29391-29400 JJ denotes different
T5466 29405-29414 NNS denotes molecules
T5467 29401-29404 NN denotes XPD
T5468 29415-29417 IN denotes at
T5469 29418-29421 DT denotes the
T5470 29422-29426 NN denotes site
T5471 29427-29429 IN denotes of
T5472 29430-29433 NN denotes DNA
T5473 29434-29440 NN denotes damage
T5474 29441-29447 IN denotes during
T5475 29448-29451 DT denotes the
T5476 29452-29458 NN denotes course
T5477 29459-29461 IN denotes of
T5478 29462-29465 DT denotes the
T5479 29473-29479 NN denotes genome
T5480 29466-29472 JJ denotes global
T5481 29480-29482 RB denotes as
T5482 29488-29490 IN denotes as
T5483 29483-29487 RB denotes well
T5484 29491-29504 NN denotes transcription
T5485 29505-29512 VBN denotes coupled
T5486 29504-29505 HYPH denotes -
T5487 29513-29519 NN denotes repair
T5488 29520-29522 IN denotes of
T5489 29523-29529 CC denotes either
T5490 29559-29565 NN denotes damage
T5491 29530-29532 NN denotes UV
T5492 29533-29540 VBN denotes induced
T5493 29532-29533 HYPH denotes -
T5494 29541-29543 CC denotes or
T5495 29544-29554 JJ denotes endogenous
T5496 29555-29558 NN denotes DNA
T5497 29565-29566 . denotes .
T5658 29877-29882 NN denotes rad15
T5607 29568-29569 DT denotes A
T5608 29580-29588 NN denotes Paradigm
T5609 29570-29579 JJ denotes Biallelic
T5610 29589-29592 IN denotes for
T5611 29593-29596 NN denotes XPD
T5612 29597-29606 NNS denotes Disorders
T5613 29606-29888 sentence denotes Recently, proteins originating from presumed null alleles were biochemically characterised as inactive in basal transcription [27], providing an explanation as to why these alleles failed to rescue lethality in haploid S. pombe with a null mutation in the XPD homologue rad15 [19].
T5614 29607-29615 RB denotes Recently
T5615 29684-29697 VBN denotes characterised
T5616 29615-29617 , denotes ,
T5617 29617-29625 NN denotes proteins
T5618 29626-29637 VBG denotes originating
T5619 29638-29642 IN denotes from
T5620 29643-29651 VBN denotes presumed
T5621 29657-29664 NNS denotes alleles
T5622 29652-29656 JJ denotes null
T5623 29665-29669 VBD denotes were
T5624 29670-29683 RB denotes biochemically
T5625 29698-29700 IN denotes as
T5626 29701-29709 JJ denotes inactive
T5627 29710-29712 IN denotes in
T5628 29713-29718 JJ denotes basal
T5629 29719-29732 NN denotes transcription
T5630 29733-29734 -LRB- denotes [
T5631 29734-29736 CD denotes 27
T5632 29736-29737 -RRB- denotes ]
T5633 29737-29739 , denotes ,
T5634 29739-29748 VBG denotes providing
T5635 29749-29751 DT denotes an
T5636 29752-29763 NN denotes explanation
T5637 29764-29766 IN denotes as
T5638 29767-29769 IN denotes to
T5639 29770-29773 WRB denotes why
T5640 29788-29794 VBD denotes failed
T5641 29774-29779 DT denotes these
T5642 29780-29787 NNS denotes alleles
T5643 29795-29797 TO denotes to
T5644 29798-29804 VB denotes rescue
T5645 29805-29814 NN denotes lethality
T5646 29815-29817 IN denotes in
T5647 29818-29825 JJ denotes haploid
T5648 29829-29834 FW denotes pombe
T5649 29826-29828 FW denotes S.
T5650 29835-29839 IN denotes with
T5651 29840-29841 DT denotes a
T5652 29847-29855 NN denotes mutation
T5653 29842-29846 JJ denotes null
T5654 29856-29858 IN denotes in
T5655 29859-29862 DT denotes the
T5656 29867-29876 NN denotes homologue
T5657 29863-29866 NN denotes XPD
T5659 29883-29884 -LRB- denotes [
T5660 29884-29886 CD denotes 19
T5661 29886-29887 -RRB- denotes ]
T5662 29887-29888 . denotes .
T5663 29888-30120 sentence denotes Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.
T5664 29889-29892 PRP$ denotes Our
T5665 29893-29897 NNS denotes data
T5666 29898-29905 VBP denotes suggest
T5667 29906-29910 IN denotes that
T5668 30015-30019 VB denotes have
T5669 29911-29918 JJ denotes certain
T5670 29933-29940 NNS denotes alleles
T5671 29919-29927 VBN denotes presumed
T5672 29928-29932 JJ denotes null
T5673 29940-29942 , denotes ,
T5674 29942-29950 IN denotes although
T5675 29951-29957 JJ denotes unable
T5676 29958-29960 IN denotes on
T5677 29974-29981 VB denotes support
T5678 29961-29966 PRP$ denotes their
T5679 29967-29970 NN denotes own
T5680 29971-29973 TO denotes to
T5681 29982-29987 JJ denotes basal
T5682 29988-30001 NN denotes transcription
T5683 30001-30003 , denotes ,
T5684 30003-30006 MD denotes may
T5685 30007-30009 IN denotes in
T5686 30010-30014 NN denotes fact
T5687 30020-30021 DT denotes a
T5688 30034-30040 NN denotes impact
T5689 30022-30033 JJ denotes substantial
T5690 30041-30043 IN denotes on
T5691 30044-30051 NN denotes disease
T5692 30052-30059 NN denotes outcome
T5693 30060-30062 IN denotes in
T5694 30063-30071 NN denotes compound
T5695 30085-30091 NNS denotes humans
T5696 30072-30084 JJ denotes heterozygous
T5697 30091-30093 , denotes ,
T5698 30093-30095 IN denotes as
T5699 30104-30106 IN denotes in
T5700 30096-30100 PRP denotes they
T5701 30101-30103 VBP denotes do
T5702 30107-30112 NN denotes mouse
T5703 30113-30119 NNS denotes models
T5704 30119-30120 . denotes .
T5705 30120-30329 sentence denotes Clinical evidence in support of this hypothesis comes from a number of XP complementation group D patients that do not fit within the framework of the current monoallelic paradigm of XPD disorders (Figure 5).
T5706 30121-30129 JJ denotes Clinical
T5707 30130-30138 NN denotes evidence
T5708 30169-30174 VBZ denotes comes
T5709 30139-30141 IN denotes in
T5710 30142-30149 NN denotes support
T5711 30150-30152 IN denotes of
T5712 30153-30157 DT denotes this
T5713 30158-30168 NN denotes hypothesis
T5714 30175-30179 IN denotes from
T5715 30180-30181 DT denotes a
T5716 30182-30188 NN denotes number
T5717 30189-30191 IN denotes of
T5718 30192-30194 NN denotes XP
T5719 30219-30227 NNS denotes patients
T5720 30195-30210 NN denotes complementation
T5721 30211-30216 NN denotes group
T5722 30217-30218 NN denotes D
T5723 30228-30232 WDT denotes that
T5724 30240-30243 VB denotes fit
T5725 30233-30235 VBP denotes do
T5726 30236-30239 RB denotes not
T5727 30244-30250 IN denotes within
T5728 30251-30254 DT denotes the
T5729 30255-30264 NN denotes framework
T5730 30265-30267 IN denotes of
T5731 30268-30271 DT denotes the
T5732 30292-30300 NN denotes paradigm
T5733 30272-30279 JJ denotes current
T5734 30280-30291 JJ denotes monoallelic
T5735 30301-30303 IN denotes of
T5736 30304-30307 NN denotes XPD
T5737 30308-30317 NNS denotes disorders
T5738 30318-30319 -LRB- denotes (
T5739 30319-30325 NN denotes Figure
T5740 30326-30327 CD denotes 5
T5741 30327-30328 -RRB- denotes )
T5742 30328-30329 . denotes .
T5743 30329-30757 sentence denotes In contrast to two hemizygous XPDXPCS patients carrying the XPDG47R- or XPDR666W-encoding alleles who died of the disease before 2 y of age, two compound heterozygous XPDXPCS patients carrying the same XPDG47R- or XPDR666W-encoding alleles in addition to the presumed null XPDL461V+del716−730 both had considerably milder disease symptoms and survived more than ten times longer (A. Lehmann, personal communication) (Figure 5).
T5744 30330-30332 IN denotes In
T5745 30628-30631 VBD denotes had
T5746 30333-30341 NN denotes contrast
T5747 30342-30344 IN denotes to
T5748 30345-30348 CD denotes two
T5749 30368-30376 NNS denotes patients
T5750 30349-30359 JJ denotes hemizygous
T5751 30360-30367 NN denotes XPDXPCS
T5752 30377-30385 VBG denotes carrying
T5753 30386-30389 DT denotes the
T5754 30420-30427 NNS denotes alleles
T5755 30390-30397 NN denotes XPDG47R
T5756 30411-30419 VBG denotes encoding
T5757 30397-30398 HYPH denotes -
T5758 30399-30401 CC denotes or
T5759 30402-30410 NN denotes XPDR666W
T5760 30410-30411 HYPH denotes -
T5761 30428-30431 WP denotes who
T5762 30432-30436 VBD denotes died
T5763 30437-30439 IN denotes of
T5764 30440-30443 DT denotes the
T5765 30444-30451 NN denotes disease
T5766 30452-30458 IN denotes before
T5767 30459-30460 CD denotes 2
T5768 30461-30462 NNS denotes y
T5769 30463-30465 IN denotes of
T5770 30466-30469 NN denotes age
T5771 30469-30471 , denotes ,
T5772 30471-30474 CD denotes two
T5773 30505-30513 NNS denotes patients
T5774 30475-30483 JJ denotes compound
T5775 30484-30496 JJ denotes heterozygous
T5776 30497-30504 NN denotes XPDXPCS
T5777 30514-30522 VBG denotes carrying
T5778 30523-30526 DT denotes the
T5779 30562-30569 NNS denotes alleles
T5780 30527-30531 JJ denotes same
T5781 30532-30539 NN denotes XPDG47R
T5782 30553-30561 VBG denotes encoding
T5783 30539-30540 HYPH denotes -
T5784 30541-30543 CC denotes or
T5785 30544-30552 NN denotes XPDR666W
T5786 30552-30553 HYPH denotes -
T5787 30570-30572 IN denotes in
T5788 30573-30581 NN denotes addition
T5789 30582-30584 IN denotes to
T5790 30585-30588 DT denotes the
T5791 30619-30622 NN denotes 730
T5792 30589-30597 VBN denotes presumed
T5793 30598-30602 JJ denotes null
T5794 30603-30611 NN denotes XPDL461V
T5795 30611-30612 SYM denotes +
T5796 30612-30618 NN denotes del716
T5797 30618-30619 HYPH denotes −
T5798 30623-30627 DT denotes both
T5799 30632-30644 RB denotes considerably
T5800 30645-30651 JJR denotes milder
T5801 30660-30668 NNS denotes symptoms
T5802 30652-30659 NN denotes disease
T5803 30669-30672 CC denotes and
T5804 30673-30681 VBD denotes survived
T5805 30682-30686 JJR denotes more
T5806 30692-30695 CD denotes ten
T5807 30687-30691 IN denotes than
T5808 30696-30701 NNS denotes times
T5809 30702-30708 RBR denotes longer
T5810 30709-30710 -LRB- denotes (
T5811 30710-30712 NNP denotes A.
T5812 30713-30720 NNP denotes Lehmann
T5813 30720-30722 , denotes ,
T5814 30722-30730 JJ denotes personal
T5815 30731-30744 NN denotes communication
T5816 30744-30745 -RRB- denotes )
T5817 30746-30747 -LRB- denotes (
T5818 30747-30753 NN denotes Figure
T5819 30754-30755 CD denotes 5
T5820 30755-30756 -RRB- denotes )
T5821 30756-30757 . denotes .
T5822 30757-30872 sentence denotes Compound heterozygosity is also associated with the recently reported combination XP and TTD (XPTTD) syndrome [8].
T5823 30758-30766 NN denotes Compound
T5824 30767-30781 NN denotes heterozygosity
T5825 30790-30800 VBN denotes associated
T5826 30782-30784 VBZ denotes is
T5827 30785-30789 RB denotes also
T5828 30801-30805 IN denotes with
T5829 30806-30809 DT denotes the
T5830 30859-30867 NN denotes syndrome
T5831 30810-30818 RB denotes recently
T5832 30819-30827 VBN denotes reported
T5833 30828-30839 NN denotes combination
T5834 30840-30842 NN denotes XP
T5835 30843-30846 CC denotes and
T5836 30847-30850 NN denotes TTD
T5837 30851-30852 -LRB- denotes (
T5838 30852-30857 NN denotes XPTTD
T5839 30857-30858 -RRB- denotes )
T5840 30868-30869 -LRB- denotes [
T5841 30869-30870 CD denotes 8
T5842 30870-30871 -RRB- denotes ]
T5843 30871-30872 . denotes .
T5844 30872-31017 sentence denotes Similar to the XpdTTD/†XPCS and XpdTTD/†XP mice described here, both patients with XPTTD described so far had intermediate hair cysteine values.
T5845 30873-30880 JJ denotes Similar
T5846 30979-30982 VBD denotes had
T5847 30881-30883 IN denotes to
T5848 30884-30887 DT denotes the
T5849 30916-30920 NNS denotes mice
T5850 30888-30894 NN denotes XpdTTD
T5851 30895-30900 NN denotes †XPCS
T5852 30894-30895 HYPH denotes /
T5853 30901-30904 CC denotes and
T5854 30905-30911 NN denotes XpdTTD
T5855 30912-30915 NN denotes †XP
T5856 30911-30912 HYPH denotes /
T5857 30921-30930 VBN denotes described
T5858 30931-30935 RB denotes here
T5859 30935-30937 , denotes ,
T5860 30937-30941 DT denotes both
T5861 30942-30950 NNS denotes patients
T5862 30951-30955 IN denotes with
T5863 30956-30961 NN denotes XPTTD
T5864 30962-30971 VBN denotes described
T5865 30972-30974 RB denotes so
T5866 30975-30978 RB denotes far
T5867 30983-30995 JJ denotes intermediate
T5868 31010-31016 NNS denotes values
T5869 30996-31000 NN denotes hair
T5870 31001-31009 NN denotes cysteine
T5871 31016-31017 . denotes .
T5872 31017-31159 sentence denotes Furthermore, XPTTD patient XP38BR carried a “causative” TTD mutation in one allele and a novel point mutation encoding XPDL485P in the other.
T5873 31018-31029 RB denotes Furthermore
T5874 31052-31059 VBD denotes carried
T5875 31029-31031 , denotes ,
T5876 31031-31036 NN denotes XPTTD
T5877 31045-31051 NN denotes XP38BR
T5878 31037-31044 NN denotes patient
T5879 31060-31061 DT denotes a
T5880 31078-31086 NN denotes mutation
T5881 31062-31063 `` denotes “
T5882 31063-31072 JJ denotes causative
T5883 31072-31073 '' denotes ”
T5884 31074-31077 NN denotes TTD
T5885 31087-31089 IN denotes in
T5886 31090-31093 CD denotes one
T5887 31094-31100 NN denotes allele
T5888 31101-31104 CC denotes and
T5889 31105-31106 DT denotes a
T5890 31119-31127 NN denotes mutation
T5891 31107-31112 JJ denotes novel
T5892 31113-31118 NN denotes point
T5893 31128-31136 VBG denotes encoding
T5894 31137-31145 NN denotes XPDL485P
T5895 31146-31148 IN denotes in
T5896 31149-31152 DT denotes the
T5897 31153-31158 JJ denotes other
T5898 31158-31159 . denotes .
T5899 31159-31447 sentence denotes Although the XPDL485P-encoding allele fails to complement viability in the haploid S. pombe rad15 deletion strain and is thus interpretable as a null allele [8], we nonetheless suggest that the combined XPTTD phenotype in this patient involves phenotypic contributions from both alleles.
T5900 31160-31168 IN denotes Although
T5901 31198-31203 VBZ denotes fails
T5902 31169-31172 DT denotes the
T5903 31191-31197 NN denotes allele
T5904 31173-31181 NN denotes XPDL485P
T5905 31182-31190 VBG denotes encoding
T5906 31181-31182 HYPH denotes -
T5907 31337-31344 VBP denotes suggest
T5908 31204-31206 TO denotes to
T5909 31207-31217 VB denotes complement
T5910 31218-31227 NN denotes viability
T5911 31228-31230 IN denotes in
T5912 31231-31234 DT denotes the
T5913 31267-31273 NN denotes strain
T5914 31235-31242 JJ denotes haploid
T5915 31243-31245 FW denotes S.
T5916 31246-31251 FW denotes pombe
T5917 31252-31257 NN denotes rad15
T5918 31258-31266 NN denotes deletion
T5919 31274-31277 CC denotes and
T5920 31278-31280 VBZ denotes is
T5921 31281-31285 RB denotes thus
T5922 31286-31299 JJ denotes interpretable
T5923 31300-31302 IN denotes as
T5924 31303-31304 DT denotes a
T5925 31310-31316 NN denotes allele
T5926 31305-31309 JJ denotes null
T5927 31317-31318 -LRB- denotes [
T5928 31318-31319 CD denotes 8
T5929 31319-31320 -RRB- denotes ]
T5930 31320-31322 , denotes ,
T5931 31322-31324 PRP denotes we
T5932 31325-31336 RB denotes nonetheless
T5933 31345-31349 IN denotes that
T5934 31395-31403 VBZ denotes involves
T5935 31350-31353 DT denotes the
T5936 31369-31378 NN denotes phenotype
T5937 31354-31362 JJ denotes combined
T5938 31363-31368 NN denotes XPTTD
T5939 31379-31381 IN denotes in
T5940 31382-31386 DT denotes this
T5941 31387-31394 NN denotes patient
T5942 31404-31414 JJ denotes phenotypic
T5943 31415-31428 NNS denotes contributions
T5944 31429-31433 IN denotes from
T5945 31434-31438 DT denotes both
T5946 31439-31446 NNS denotes alleles
T5947 31446-31447 . denotes .
T5948 31447-31580 sentence denotes Taken together, these data suggest a shift to a biallelic paradigm for compound heterozygous patients in XP complementation group D.
T5949 31448-31453 VBN denotes Taken
T5950 31475-31482 VBP denotes suggest
T5951 31454-31462 RB denotes together
T5952 31462-31464 , denotes ,
T5953 31464-31469 DT denotes these
T5954 31470-31474 NNS denotes data
T5955 31483-31484 DT denotes a
T5956 31485-31490 NN denotes shift
T5957 31491-31493 IN denotes to
T5958 31494-31495 DT denotes a
T5959 31506-31514 NN denotes paradigm
T5960 31496-31505 JJ denotes biallelic
T5961 31515-31518 IN denotes for
T5962 31519-31527 NN denotes compound
T5963 31541-31549 NNS denotes patients
T5964 31528-31540 JJ denotes heterozygous
T5965 31550-31552 IN denotes in
T5966 31553-31555 NN denotes XP
T5967 31578-31579 NN denotes D
T5968 31556-31571 NN denotes complementation
T5969 31572-31577 NN denotes group
T5970 31579-31580 . denotes .
T6041 32357-32366 NN denotes Potential
T6042 32367-32369 IN denotes of
T6043 32370-32378 VBN denotes Combined
T6044 32389-32396 NNS denotes Alleles
T6045 32379-32388 JJ denotes Recessive
T6046 32397-32399 TO denotes to
T6047 32400-32406 VB denotes Affect
T6048 32407-32417 JJ denotes Phenotypic
T6049 32418-32427 NN denotes Diversity
T6050 32428-32430 IN denotes in
T6051 32431-32438 NNS denotes Mammals
T6052 32438-32547 sentence denotes In humans, the clinical relevance of biallelic effects such as interallelic complementation remains unknown.
T6053 32439-32441 IN denotes In
T6054 32531-32538 VBZ denotes remains
T6055 32442-32448 NNS denotes humans
T6056 32448-32450 , denotes ,
T6057 32450-32453 DT denotes the
T6058 32463-32472 NN denotes relevance
T6059 32454-32462 JJ denotes clinical
T6060 32473-32475 IN denotes of
T6061 32476-32485 JJ denotes biallelic
T6062 32486-32493 NNS denotes effects
T6063 32494-32498 JJ denotes such
T6064 32499-32501 IN denotes as
T6065 32502-32514 JJ denotes interallelic
T6066 32515-32530 NN denotes complementation
T6067 32539-32546 JJ denotes unknown
T6068 32546-32547 . denotes .
T6069 32547-32791 sentence denotes Although interallelic complementation between two endogenous mutant alleles has been described in cells from a compound heterozygous patient with methylmalonic acidaemia, no observable effects on disease outcome were noted in the patient [28].
T6070 32548-32556 IN denotes Although
T6071 32633-32642 VBN denotes described
T6072 32557-32569 JJ denotes interallelic
T6073 32570-32585 NN denotes complementation
T6074 32586-32593 IN denotes between
T6075 32594-32597 CD denotes two
T6076 32616-32623 NNS denotes alleles
T6077 32598-32608 JJ denotes endogenous
T6078 32609-32615 JJ denotes mutant
T6079 32624-32627 VBZ denotes has
T6080 32628-32632 VBN denotes been
T6081 32765-32770 VBN denotes noted
T6082 32643-32645 IN denotes in
T6083 32646-32651 NNS denotes cells
T6084 32652-32656 IN denotes from
T6085 32657-32658 DT denotes a
T6086 32681-32688 NN denotes patient
T6087 32659-32667 NN denotes compound
T6088 32668-32680 JJ denotes heterozygous
T6089 32689-32693 IN denotes with
T6090 32694-32707 JJ denotes methylmalonic
T6091 32708-32717 NN denotes acidaemia
T6092 32717-32719 , denotes ,
T6093 32719-32721 DT denotes no
T6094 32733-32740 NNS denotes effects
T6095 32722-32732 JJ denotes observable
T6096 32741-32743 IN denotes on
T6097 32744-32751 NN denotes disease
T6098 32752-32759 NN denotes outcome
T6099 32760-32764 VBD denotes were
T6100 32771-32773 IN denotes in
T6101 32774-32777 DT denotes the
T6102 32778-32785 NN denotes patient
T6103 32786-32787 -LRB- denotes [
T6104 32787-32789 CD denotes 28
T6105 32789-32790 -RRB- denotes ]
T6106 32790-32791 . denotes .
T6107 32791-33009 sentence denotes Thus, to the best of our knowledge, the amelioration of progeroid features observed here is the first in vivo demonstration in compound heterozygous animals of interallelic complementation relevant to a human disease.
T6108 32792-32796 RB denotes Thus
T6109 32881-32883 VBZ denotes is
T6110 32796-32798 , denotes ,
T6111 32798-32800 IN denotes to
T6112 32801-32804 DT denotes the
T6113 32805-32809 JJS denotes best
T6114 32810-32812 IN denotes of
T6115 32813-32816 PRP$ denotes our
T6116 32817-32826 NN denotes knowledge
T6117 32826-32828 , denotes ,
T6118 32828-32831 DT denotes the
T6119 32832-32844 NN denotes amelioration
T6120 32845-32847 IN denotes of
T6121 32848-32857 JJ denotes progeroid
T6122 32858-32866 NNS denotes features
T6123 32867-32875 VBN denotes observed
T6124 32876-32880 RB denotes here
T6125 32884-32887 DT denotes the
T6126 32902-32915 NN denotes demonstration
T6127 32888-32893 JJ denotes first
T6128 32894-32896 FW denotes in
T6129 32897-32901 FW denotes vivo
T6130 32916-32918 IN denotes in
T6131 32919-32927 NN denotes compound
T6132 32941-32948 NNS denotes animals
T6133 32928-32940 JJ denotes heterozygous
T6134 32949-32951 IN denotes of
T6135 32952-32964 JJ denotes interallelic
T6136 32965-32980 NN denotes complementation
T6137 32981-32989 JJ denotes relevant
T6138 32990-32992 IN denotes to
T6139 32993-32994 DT denotes a
T6140 33001-33008 NN denotes disease
T6141 32995-33000 JJ denotes human
T6142 33008-33009 . denotes .
T6143 33009-33385 sentence denotes Keeping in mind that the ~1,200 alleles known to exist for the CTRF gene implicated in the common autosomal recessive disorder cystic fibrosis alone [29] can theoretically result in ~700,000 different allelic combinations, the potential number of allelic combinations of different recessive mutations and single nucleotide polymorphisms genome-wide is currently incalculable.
T6144 33010-33017 VBG denotes Keeping
T6145 33359-33361 VBZ denotes is
T6146 33018-33020 IN denotes in
T6147 33021-33025 NN denotes mind
T6148 33026-33030 IN denotes that
T6149 33182-33188 VB denotes result
T6150 33031-33034 DT denotes the
T6151 33042-33049 NNS denotes alleles
T6152 33035-33036 SYM denotes ~
T6153 33036-33041 CD denotes 1,200
T6154 33050-33055 VBN denotes known
T6155 33056-33058 TO denotes to
T6156 33059-33064 VB denotes exist
T6157 33065-33068 IN denotes for
T6158 33069-33072 DT denotes the
T6159 33078-33082 NN denotes gene
T6160 33073-33077 NN denotes CTRF
T6161 33083-33093 VBN denotes implicated
T6162 33094-33096 IN denotes in
T6163 33097-33100 DT denotes the
T6164 33128-33136 NN denotes disorder
T6165 33101-33107 JJ denotes common
T6166 33108-33117 JJ denotes autosomal
T6167 33118-33127 JJ denotes recessive
T6168 33137-33143 JJ denotes cystic
T6169 33144-33152 NN denotes fibrosis
T6170 33153-33158 RB denotes alone
T6171 33159-33160 -LRB- denotes [
T6172 33160-33162 CD denotes 29
T6173 33162-33163 -RRB- denotes ]
T6174 33164-33167 MD denotes can
T6175 33168-33181 RB denotes theoretically
T6176 33189-33191 IN denotes in
T6177 33192-33193 SYM denotes ~
T6178 33193-33200 CD denotes 700,000
T6179 33219-33231 NNS denotes combinations
T6180 33201-33210 JJ denotes different
T6181 33211-33218 JJ denotes allelic
T6182 33231-33233 , denotes ,
T6183 33233-33236 DT denotes the
T6184 33247-33253 NN denotes number
T6185 33237-33246 JJ denotes potential
T6186 33254-33256 IN denotes of
T6187 33257-33264 JJ denotes allelic
T6188 33265-33277 NNS denotes combinations
T6189 33278-33280 IN denotes of
T6190 33281-33290 JJ denotes different
T6191 33301-33310 NNS denotes mutations
T6192 33291-33300 JJ denotes recessive
T6193 33311-33314 CC denotes and
T6194 33315-33321 JJ denotes single
T6195 33333-33346 NNS denotes polymorphisms
T6196 33322-33332 NN denotes nucleotide
T6197 33347-33353 NN denotes genome
T6198 33354-33358 JJ denotes wide
T6199 33353-33354 HYPH denotes -
T6200 33362-33371 RB denotes currently
T6201 33372-33384 JJ denotes incalculable
T6202 33384-33385 . denotes .
T6203 33385-33592 sentence denotes We suggest biallelic effects as a previously underestimated yet important variable in considering genotype–phenotype relationships from autosomal recessive disease to normal phenotypic diversity in mammals.
T6204 33386-33388 PRP denotes We
T6205 33389-33396 VBP denotes suggest
T6206 33397-33406 JJ denotes biallelic
T6207 33407-33414 NNS denotes effects
T6208 33415-33417 IN denotes as
T6209 33418-33419 DT denotes a
T6210 33460-33468 NN denotes variable
T6211 33420-33430 RB denotes previously
T6212 33431-33445 VBN denotes underestimated
T6213 33450-33459 JJ denotes important
T6214 33446-33449 RB denotes yet
T6215 33469-33471 IN denotes in
T6216 33472-33483 VBG denotes considering
T6217 33484-33492 NN denotes genotype
T6218 33493-33502 NN denotes phenotype
T6219 33492-33493 HYPH denotes –
T6220 33503-33516 NNS denotes relationships
T6221 33517-33521 IN denotes from
T6222 33522-33531 JJ denotes autosomal
T6223 33542-33549 NN denotes disease
T6224 33532-33541 JJ denotes recessive
T6225 33550-33552 IN denotes to
T6226 33553-33559 JJ denotes normal
T6227 33571-33580 NN denotes diversity
T6228 33560-33570 JJ denotes phenotypic
T6229 33581-33583 IN denotes in
T6230 33584-33591 NNS denotes mammals
T6231 33591-33592 . denotes .
T6232 33592-33769 sentence denotes Extension of the above concept implies that recessive mutations can enter evolutionary selection in F1 provided that the second allele carries a different recessive alteration.
T6233 33593-33602 NN denotes Extension
T6234 33624-33631 VBZ denotes implies
T6235 33603-33605 IN denotes of
T6236 33606-33609 DT denotes the
T6237 33616-33623 NN denotes concept
T6238 33610-33615 JJ denotes above
T6239 33632-33636 IN denotes that
T6240 33661-33666 VB denotes enter
T6241 33637-33646 JJ denotes recessive
T6242 33647-33656 NNS denotes mutations
T6243 33657-33660 MD denotes can
T6244 33667-33679 JJ denotes evolutionary
T6245 33680-33689 NN denotes selection
T6246 33690-33692 IN denotes in
T6247 33693-33695 NN denotes F1
T6248 33696-33704 VBN denotes provided
T6249 33705-33709 IN denotes that
T6250 33728-33735 VBZ denotes carries
T6251 33710-33713 DT denotes the
T6252 33721-33727 NN denotes allele
T6253 33714-33720 JJ denotes second
T6254 33736-33737 DT denotes a
T6255 33758-33768 NN denotes alteration
T6256 33738-33747 JJ denotes different
T6257 33748-33757 JJ denotes recessive
T6258 33768-33769 . denotes .
T6259 33769-33966 sentence denotes Finally, our data highlight the potential of clinically relevant alleles previously designated as null, with little or no detectable expression or activity, to nonetheless contribute to phenotype.
T6260 33770-33777 RB denotes Finally
T6261 33788-33797 VBP denotes highlight
T6262 33777-33779 , denotes ,
T6263 33779-33782 PRP$ denotes our
T6264 33783-33787 NNS denotes data
T6265 33798-33801 DT denotes the
T6266 33802-33811 NN denotes potential
T6267 33812-33814 IN denotes of
T6268 33815-33825 RB denotes clinically
T6269 33826-33834 JJ denotes relevant
T6270 33835-33842 NNS denotes alleles
T6271 33843-33853 RB denotes previously
T6272 33854-33864 VBN denotes designated
T6273 33865-33867 IN denotes as
T6274 33868-33872 JJ denotes null
T6275 33872-33874 , denotes ,
T6276 33874-33878 IN denotes with
T6277 33879-33885 JJ denotes little
T6278 33903-33913 NN denotes expression
T6279 33886-33888 CC denotes or
T6280 33889-33891 DT denotes no
T6281 33892-33902 JJ denotes detectable
T6282 33914-33916 CC denotes or
T6283 33917-33925 NN denotes activity
T6284 33925-33927 , denotes ,
T6285 33927-33929 TO denotes to
T6286 33942-33952 VB denotes contribute
T6287 33930-33941 RB denotes nonetheless
T6288 33953-33955 IN denotes to
T6289 33956-33965 NN denotes phenotype
T6290 33965-33966 . denotes .
T6364 33991-34001 NN denotes Derivation
T6365 34002-34005 CC denotes and
T6366 34006-34014 NN denotes analysis
T6367 34015-34017 IN denotes of
T6368 34018-34024 JJ denotes mutant
T6369 34025-34029 NNS denotes mice
T6370 34029-34030 . denotes .
T6371 34030-34120 sentence denotes Generation of XpdTTD (XPDR722W) and XpdTTD/KO mice has been described previously [21,22].
T6372 34031-34041 NN denotes Generation
T6373 34091-34100 VBN denotes described
T6374 34042-34044 IN denotes of
T6375 34045-34051 NN denotes XpdTTD
T6376 34077-34081 NNS denotes mice
T6377 34052-34053 -LRB- denotes (
T6378 34053-34061 NN denotes XPDR722W
T6379 34061-34062 -RRB- denotes )
T6380 34063-34066 CC denotes and
T6381 34067-34073 NN denotes XpdTTD
T6382 34074-34076 NN denotes KO
T6383 34073-34074 HYPH denotes /
T6384 34082-34085 VBZ denotes has
T6385 34086-34090 VBN denotes been
T6386 34101-34111 RB denotes previously
T6387 34112-34113 -LRB- denotes [
T6388 34116-34118 CD denotes 22
T6389 34113-34115 CD denotes 21
T6390 34115-34116 , denotes ,
T6391 34118-34119 -RRB- denotes ]
T6392 34119-34120 . denotes .
T6393 34120-34309 sentence denotes A detailed description of the generation of targeting constructs for Xpd†XPCS and Xpd †XP alleles carrying mutations encoding the G602D and R683W alterations will be provided upon request.
T6394 34121-34122 DT denotes A
T6395 34132-34143 NN denotes description
T6396 34123-34131 JJ denotes detailed
T6397 34287-34295 VBN denotes provided
T6398 34144-34146 IN denotes of
T6399 34147-34150 DT denotes the
T6400 34151-34161 NN denotes generation
T6401 34162-34164 IN denotes of
T6402 34165-34174 VBG denotes targeting
T6403 34175-34185 NNS denotes constructs
T6404 34186-34189 IN denotes for
T6405 34190-34198 NN denotes Xpd†XPCS
T6406 34211-34218 NNS denotes alleles
T6407 34199-34202 CC denotes and
T6408 34203-34210 NN denotes Xpd †XP
T6409 34219-34227 VBG denotes carrying
T6410 34228-34237 NNS denotes mutations
T6411 34238-34246 VBG denotes encoding
T6412 34247-34250 DT denotes the
T6413 34267-34278 NNS denotes alterations
T6414 34251-34256 NN denotes G602D
T6415 34257-34260 CC denotes and
T6416 34261-34266 NN denotes R683W
T6417 34279-34283 MD denotes will
T6418 34284-34286 VB denotes be
T6419 34296-34300 IN denotes upon
T6420 34301-34308 NN denotes request
T6421 34308-34309 . denotes .
T6422 34309-34404 sentence denotes Chimeric mice and mouse embryonic fibroblasts were generated according to standard procedures.
T6423 34310-34318 JJ denotes Chimeric
T6424 34344-34355 NNS denotes fibroblasts
T6425 34319-34323 NNS denotes mice
T6426 34324-34327 CC denotes and
T6427 34328-34333 NN denotes mouse
T6428 34334-34343 JJ denotes embryonic
T6429 34361-34370 VBN denotes generated
T6430 34356-34360 VBD denotes were
T6431 34371-34380 VBG denotes according
T6432 34381-34383 IN denotes to
T6433 34384-34392 JJ denotes standard
T6434 34393-34403 NNS denotes procedures
T6435 34403-34404 . denotes .
T6436 34404-34484 sentence denotes Haematoxylin and eosin staining was performed according to standard procedures.
T6437 34405-34417 NN denotes Haematoxylin
T6438 34428-34436 NN denotes staining
T6439 34418-34421 CC denotes and
T6440 34422-34427 NN denotes eosin
T6441 34441-34450 VBN denotes performed
T6442 34437-34440 VBD denotes was
T6443 34451-34460 VBG denotes according
T6444 34461-34463 IN denotes to
T6445 34464-34472 JJ denotes standard
T6446 34473-34483 NNS denotes procedures
T6447 34483-34484 . denotes .
T6448 34484-34540 sentence denotes Amino acid analysis was conducted as described in [21].
T6449 34485-34490 NN denotes Amino
T6450 34491-34495 NN denotes acid
T6451 34496-34504 NN denotes analysis
T6452 34509-34518 VBN denotes conducted
T6453 34505-34508 VBD denotes was
T6454 34519-34521 IN denotes as
T6455 34522-34531 VBN denotes described
T6456 34532-34534 IN denotes in
T6457 34535-34536 -LRB- denotes [
T6458 34536-34538 CD denotes 21
T6459 34538-34539 -RRB- denotes ]
T6460 34539-34540 . denotes .
T6461 34540-34637 sentence denotes Blood values were analysed using Animal Blood Counter Vet (ABX Diagnostix, Montpellier, France).
T6462 34541-34546 NN denotes Blood
T6463 34547-34553 NNS denotes values
T6464 34559-34567 VBN denotes analysed
T6465 34554-34558 VBD denotes were
T6466 34568-34573 VBG denotes using
T6467 34574-34580 NN denotes Animal
T6468 34595-34598 NN denotes Vet
T6469 34581-34586 NN denotes Blood
T6470 34587-34594 JJ denotes Counter
T6471 34599-34600 -LRB- denotes (
T6472 34604-34614 NNP denotes Diagnostix
T6473 34600-34603 NNP denotes ABX
T6474 34614-34616 , denotes ,
T6475 34616-34627 NNP denotes Montpellier
T6476 34627-34629 , denotes ,
T6477 34629-34635 NNP denotes France
T6478 34635-34636 -RRB- denotes )
T6479 34636-34637 . denotes .
T6480 34637-34732 sentence denotes Radiographs were taken, and relative bone mineral density was calculated as described in [15].
T6481 34638-34649 NNS denotes Radiographs
T6482 34655-34660 VBN denotes taken
T6483 34650-34654 VBD denotes were
T6484 34660-34662 , denotes ,
T6485 34662-34665 CC denotes and
T6486 34666-34674 JJ denotes relative
T6487 34688-34695 NN denotes density
T6488 34675-34679 NN denotes bone
T6489 34680-34687 NN denotes mineral
T6490 34700-34710 VBN denotes calculated
T6491 34696-34699 VBD denotes was
T6492 34711-34713 IN denotes as
T6493 34714-34723 VBN denotes described
T6494 34724-34726 IN denotes in
T6495 34727-34728 -LRB- denotes [
T6496 34728-34730 CD denotes 15
T6497 34730-34731 -RRB- denotes ]
T6498 34731-34732 . denotes .
T6499 34732-34823 sentence denotes Mice used in this study were in a 129Ola/C57BL6 mixed background unless noted differently.
T6500 34733-34737 NNS denotes Mice
T6501 34757-34761 VBD denotes were
T6502 34738-34742 VBN denotes used
T6503 34743-34745 IN denotes in
T6504 34746-34750 DT denotes this
T6505 34751-34756 NN denotes study
T6506 34762-34764 IN denotes in
T6507 34765-34766 DT denotes a
T6508 34787-34797 NN denotes background
T6509 34767-34773 NN denotes 129Ola
T6510 34774-34780 NN denotes C57BL6
T6511 34773-34774 HYPH denotes /
T6512 34781-34786 JJ denotes mixed
T6513 34798-34804 IN denotes unless
T6514 34805-34810 VBN denotes noted
T6515 34811-34822 RB denotes differently
T6516 34822-34823 . denotes .
T6517 34823-35050 sentence denotes All experiments involving mice were judged and approved by the national committee for genetic identification of organisms and the animal ethical committee, and were conducted according to national and international guidelines.
T6518 34824-34827 DT denotes All
T6519 34828-34839 NNS denotes experiments
T6520 34860-34866 VBN denotes judged
T6521 34840-34849 VBG denotes involving
T6522 34850-34854 NNS denotes mice
T6523 34855-34859 VBD denotes were
T6524 34867-34870 CC denotes and
T6525 34871-34879 VBN denotes approved
T6526 34880-34882 IN denotes by
T6527 34883-34886 DT denotes the
T6528 34896-34905 NN denotes committee
T6529 34887-34895 JJ denotes national
T6530 34906-34909 IN denotes for
T6531 34910-34917 JJ denotes genetic
T6532 34918-34932 NN denotes identification
T6533 34933-34935 IN denotes of
T6534 34936-34945 NNS denotes organisms
T6535 34946-34949 CC denotes and
T6536 34950-34953 DT denotes the
T6537 34969-34978 NN denotes committee
T6538 34954-34960 NN denotes animal
T6539 34961-34968 JJ denotes ethical
T6540 34978-34980 , denotes ,
T6541 34980-34983 CC denotes and
T6542 34984-34988 VBD denotes were
T6543 34989-34998 VBN denotes conducted
T6544 34999-35008 VBG denotes according
T6545 35009-35011 IN denotes to
T6546 35012-35020 JJ denotes national
T6547 35039-35049 NNS denotes guidelines
T6548 35021-35024 CC denotes and
T6549 35025-35038 JJ denotes international
T6550 35049-35050 . denotes .
T6587 35052-35054 NN denotes UV
T6588 35055-35066 NN denotes sensitivity
T6589 35066-35068 , denotes ,
T6590 35068-35070 NN denotes UV
T6591 35071-35074 NN denotes UDS
T6592 35070-35071 HYPH denotes -
T6593 35112-35120 NN denotes activity
T6594 35074-35076 , denotes ,
T6595 35076-35078 NN denotes UV
T6596 35079-35082 NN denotes RRS
T6597 35078-35079 HYPH denotes -
T6598 35082-35084 , denotes ,
T6599 35084-35087 CC denotes and
T6600 35088-35093 NN denotes TFIIH
T6601 35094-35102 NN denotes incision
T6602 35103-35111 NN denotes excision
T6603 35102-35103 HYPH denotes /
T6604 35120-35121 . denotes .
T6605 35121-35208 sentence denotes UV survival, UV-UDS, and UV-RRS assays were performed as described previously [21,30].
T6606 35122-35124 NN denotes UV
T6607 35125-35133 NN denotes survival
T6608 35154-35160 NNS denotes assays
T6609 35133-35135 , denotes ,
T6610 35135-35137 NN denotes UV
T6611 35138-35141 NN denotes UDS
T6612 35137-35138 HYPH denotes -
T6613 35141-35143 , denotes ,
T6614 35143-35146 CC denotes and
T6615 35147-35149 NN denotes UV
T6616 35150-35153 NN denotes RRS
T6617 35149-35150 HYPH denotes -
T6618 35166-35175 VBN denotes performed
T6619 35161-35165 VBD denotes were
T6620 35176-35178 IN denotes as
T6621 35179-35188 VBN denotes described
T6622 35189-35199 RB denotes previously
T6623 35200-35201 -LRB- denotes [
T6624 35204-35206 CD denotes 30
T6625 35201-35203 CD denotes 21
T6626 35203-35204 , denotes ,
T6627 35206-35207 -RRB- denotes ]
T6628 35207-35208 . denotes .
T6629 35208-35367 sentence denotes For UV-RRS, average values from the representative experiment containing two wt, three XpdTTD/TTD, two XpdTTD/XPCS, and one XpdTTD/XP cell line are presented.
T6630 35209-35212 IN denotes For
T6631 35357-35366 VBN denotes presented
T6632 35213-35215 NN denotes UV
T6633 35216-35219 NN denotes RRS
T6634 35215-35216 HYPH denotes -
T6635 35219-35221 , denotes ,
T6636 35221-35228 JJ denotes average
T6637 35229-35235 NNS denotes values
T6638 35236-35240 IN denotes from
T6639 35241-35244 DT denotes the
T6640 35260-35270 NN denotes experiment
T6641 35245-35259 JJ denotes representative
T6642 35271-35281 VBG denotes containing
T6643 35282-35285 CD denotes two
T6644 35286-35288 NN denotes wt
T6645 35348-35352 NN denotes line
T6646 35288-35290 , denotes ,
T6647 35290-35295 CD denotes three
T6648 35303-35306 NN denotes TTD
T6649 35296-35302 NN denotes XpdTTD
T6650 35302-35303 HYPH denotes /
T6651 35306-35308 , denotes ,
T6652 35308-35311 CD denotes two
T6653 35319-35323 NN denotes XPCS
T6654 35312-35318 NN denotes XpdTTD
T6655 35318-35319 HYPH denotes /
T6656 35323-35325 , denotes ,
T6657 35325-35328 CC denotes and
T6658 35329-35332 CD denotes one
T6659 35340-35342 NN denotes XP
T6660 35333-35339 NN denotes XpdTTD
T6661 35339-35340 HYPH denotes /
T6662 35343-35347 NN denotes cell
T6663 35353-35356 VBP denotes are
T6664 35366-35367 . denotes .
T6665 35367-35615 sentence denotes The ~48% UV-UDS value presented in this study for XpdTTD/TTD cells differs from our previously published data of 25% UV-UDS [21], possibly because of the high variability intrinsic to the assay or routine variations in the cell culture conditions.
T6666 35368-35371 DT denotes The
T6667 35384-35389 NN denotes value
T6668 35372-35373 SYM denotes ~
T6669 35373-35375 CD denotes 48
T6670 35375-35376 NN denotes %
T6671 35377-35379 NN denotes UV
T6672 35380-35383 NN denotes UDS
T6673 35379-35380 HYPH denotes -
T6674 35435-35442 VBZ denotes differs
T6675 35390-35399 VBN denotes presented
T6676 35400-35402 IN denotes in
T6677 35403-35407 DT denotes this
T6678 35408-35413 NN denotes study
T6679 35414-35417 IN denotes for
T6680 35418-35424 NN denotes XpdTTD
T6681 35425-35428 NN denotes TTD
T6682 35424-35425 HYPH denotes /
T6683 35429-35434 NNS denotes cells
T6684 35443-35447 IN denotes from
T6685 35448-35451 PRP$ denotes our
T6686 35473-35477 NNS denotes data
T6687 35452-35462 RB denotes previously
T6688 35463-35472 VBN denotes published
T6689 35478-35480 IN denotes of
T6690 35481-35483 CD denotes 25
T6691 35483-35484 NN denotes %
T6692 35488-35491 NN denotes UDS
T6693 35485-35487 NN denotes UV
T6694 35487-35488 HYPH denotes -
T6695 35492-35493 -LRB- denotes [
T6696 35493-35495 CD denotes 21
T6697 35495-35496 -RRB- denotes ]
T6698 35496-35498 , denotes ,
T6699 35498-35506 RB denotes possibly
T6700 35507-35514 IN denotes because
T6701 35515-35517 IN denotes of
T6702 35518-35521 DT denotes the
T6703 35527-35538 NN denotes variability
T6704 35522-35526 JJ denotes high
T6705 35539-35548 JJ denotes intrinsic
T6706 35549-35551 IN denotes to
T6707 35552-35555 DT denotes the
T6708 35556-35561 NN denotes assay
T6709 35562-35564 CC denotes or
T6710 35565-35572 JJ denotes routine
T6711 35573-35583 NNS denotes variations
T6712 35584-35586 IN denotes in
T6713 35587-35590 DT denotes the
T6714 35604-35614 NNS denotes conditions
T6715 35591-35595 NN denotes cell
T6716 35596-35603 NN denotes culture
T6717 35614-35615 . denotes .
T6718 35615-35730 sentence denotes For the incision/excision activity assay, recombinant TFIIH was prepared and assayed as described previously [27].
T6719 35616-35619 IN denotes For
T6720 35680-35688 VBN denotes prepared
T6721 35620-35623 DT denotes the
T6722 35651-35656 NN denotes assay
T6723 35624-35632 NN denotes incision
T6724 35633-35641 NN denotes excision
T6725 35632-35633 HYPH denotes /
T6726 35642-35650 NN denotes activity
T6727 35656-35658 , denotes ,
T6728 35658-35669 JJ denotes recombinant
T6729 35670-35675 NN denotes TFIIH
T6730 35676-35679 VBD denotes was
T6731 35689-35692 CC denotes and
T6732 35693-35700 VBN denotes assayed
T6733 35701-35703 IN denotes as
T6734 35704-35713 VBN denotes described
T6735 35714-35724 RB denotes previously
T6736 35725-35726 -LRB- denotes [
T6737 35726-35728 CD denotes 27
T6738 35728-35729 -RRB- denotes ]
T6739 35729-35730 . denotes .
T6809 35965-36162 sentence denotes Two or more cell lines per genotype (except for the XpdTTD/†XP cells, in which only one cell line was used in repeated experiments) were used, and experiments were repeated 2–6 times per genotype.
T6810 35966-35969 CD denotes Two
T6811 35983-35988 NNS denotes lines
T6812 35970-35972 CC denotes or
T6813 35973-35977 JJR denotes more
T6814 35978-35982 NN denotes cell
T6815 36103-36107 VBN denotes used
T6816 35989-35992 IN denotes per
T6817 35993-36001 NN denotes genotype
T6818 36002-36003 -LRB- denotes (
T6819 36003-36009 IN denotes except
T6820 36010-36013 IN denotes for
T6821 36014-36017 DT denotes the
T6822 36029-36034 NNS denotes cells
T6823 36018-36024 NN denotes XpdTTD
T6824 36025-36028 NN denotes †XP
T6825 36024-36025 HYPH denotes /
T6826 36034-36036 , denotes ,
T6827 36036-36038 IN denotes in
T6828 36068-36072 VBN denotes used
T6829 36039-36044 WDT denotes which
T6830 36045-36049 RB denotes only
T6831 36059-36063 NN denotes line
T6832 36050-36053 CD denotes one
T6833 36054-36058 NN denotes cell
T6834 36064-36067 VBD denotes was
T6835 36073-36075 IN denotes in
T6836 36076-36084 VBN denotes repeated
T6837 36085-36096 NNS denotes experiments
T6838 36096-36097 -RRB- denotes )
T6839 36098-36102 VBD denotes were
T6840 36107-36109 , denotes ,
T6841 36109-36112 CC denotes and
T6842 36113-36124 NNS denotes experiments
T6843 36130-36138 VBN denotes repeated
T6844 36125-36129 VBD denotes were
T6845 36139-36140 CD denotes 2
T6846 36141-36142 CD denotes 6
T6847 36140-36141 HYPH denotes –
T6848 36143-36148 NNS denotes times
T6849 36149-36152 IN denotes per
T6850 36153-36161 NN denotes genotype
T6851 36161-36162 . denotes .
T7095 7546-7555 NN denotes Targeting
T7096 7556-7558 IN denotes of
T7097 7559-7562 DT denotes the
T7098 7573-7577 NN denotes Gene
T7099 7563-7568 NN denotes Mouse
T7100 7569-7572 NN denotes Xpd
T7101 7577-7698 sentence denotes (A) Schematic representation of the genomic structure and partial restriction map of the wt and targeted mouse Xpd loci.
T7102 7578-7579 -LRB- denotes (
T7103 7579-7580 LS denotes A
T7104 7592-7606 NN denotes representation
T7105 7580-7581 -RRB- denotes )
T7106 7582-7591 JJ denotes Schematic
T7107 7607-7609 IN denotes of
T7108 7610-7613 DT denotes the
T7109 7622-7631 NN denotes structure
T7110 7614-7621 JJ denotes genomic
T7111 7632-7635 CC denotes and
T7112 7636-7643 JJ denotes partial
T7113 7656-7659 NN denotes map
T7114 7644-7655 NN denotes restriction
T7115 7660-7662 IN denotes of
T7116 7663-7666 DT denotes the
T7117 7693-7697 NNS denotes loci
T7118 7667-7669 NN denotes wt
T7119 7670-7673 CC denotes and
T7120 7674-7682 VBN denotes targeted
T7121 7683-7688 NN denotes mouse
T7122 7689-7692 NN denotes Xpd
T7123 7697-7698 . denotes .
T7124 7698-7823 sentence denotes For the wt Xpd allele, shaded boxes represent coding regions of exons 12 and 19–23; the 3′UTR is represented by an open box.
T7125 7699-7702 IN denotes For
T7126 7796-7807 VBN denotes represented
T7127 7703-7706 DT denotes the
T7128 7714-7720 NN denotes allele
T7129 7707-7709 NN denotes wt
T7130 7710-7713 NN denotes Xpd
T7131 7720-7722 , denotes ,
T7132 7722-7728 JJ denotes shaded
T7133 7729-7734 NNS denotes boxes
T7134 7735-7744 VBP denotes represent
T7135 7745-7751 VBG denotes coding
T7136 7752-7759 NNS denotes regions
T7137 7760-7762 IN denotes of
T7138 7763-7768 NNS denotes exons
T7139 7769-7771 CD denotes 12
T7140 7772-7775 CC denotes and
T7141 7776-7778 CD denotes 19
T7142 7778-7779 SYM denotes –
T7143 7779-7781 CD denotes 23
T7144 7781-7782 : denotes ;
T7145 7783-7786 DT denotes the
T7146 7789-7792 NN denotes UTR
T7147 7787-7788 CD denotes 3
T7148 7788-7789 SYM denotes ′
T7149 7793-7795 VBZ denotes is
T7150 7808-7810 IN denotes by
T7151 7811-7813 DT denotes an
T7152 7819-7822 NN denotes box
T7153 7814-7818 JJ denotes open
T7154 7822-7823 . denotes .
T7155 7823-7911 sentence denotes TGA indicates the translational stop codon; PolyA indicates the polyadenylation signal.
T7156 7824-7827 NN denotes TGA
T7157 7828-7837 VBZ denotes indicates
T7158 7874-7883 VBZ denotes indicates
T7159 7838-7841 DT denotes the
T7160 7861-7866 NN denotes codon
T7161 7842-7855 JJ denotes translational
T7162 7856-7860 NN denotes stop
T7163 7866-7867 : denotes ;
T7164 7868-7873 NN denotes PolyA
T7165 7884-7887 DT denotes the
T7166 7904-7910 NN denotes signal
T7167 7888-7903 NN denotes polyadenylation
T7168 7910-7911 . denotes .
T7169 7911-8103 sentence denotes For the XpdTTD targeted allele, the 194–base pair (bp) human XPD cDNA fragment fused to exon 22 is indicated as a striped box including the TTD (R722W) mutation indicated by a vertical arrow.
T7170 7912-7915 IN denotes For
T7171 8011-8020 VBN denotes indicated
T7172 7916-7919 DT denotes the
T7173 7936-7942 NN denotes allele
T7174 7920-7926 NN denotes XpdTTD
T7175 7927-7935 VBN denotes targeted
T7176 7942-7944 , denotes ,
T7177 7944-7947 DT denotes the
T7178 7982-7990 NN denotes fragment
T7179 7948-7951 CD denotes 194
T7180 7957-7961 NN denotes pair
T7181 7951-7952 HYPH denotes –
T7182 7952-7956 NN denotes base
T7183 7962-7963 -LRB- denotes (
T7184 7963-7965 NN denotes bp
T7185 7965-7966 -RRB- denotes )
T7186 7967-7972 JJ denotes human
T7187 7973-7976 NN denotes XPD
T7188 7977-7981 NN denotes cDNA
T7189 7991-7996 VBN denotes fused
T7190 7997-7999 IN denotes to
T7191 8000-8004 NN denotes exon
T7192 8005-8007 CD denotes 22
T7193 8008-8010 VBZ denotes is
T7194 8021-8023 IN denotes as
T7195 8024-8025 DT denotes a
T7196 8034-8037 NN denotes box
T7197 8026-8033 VBN denotes striped
T7198 8038-8047 VBG denotes including
T7199 8048-8051 DT denotes the
T7200 8064-8072 NN denotes mutation
T7201 8052-8055 NN denotes TTD
T7202 8056-8057 -LRB- denotes (
T7203 8057-8062 NN denotes R722W
T7204 8062-8063 -RRB- denotes )
T7205 8073-8082 VBN denotes indicated
T7206 8083-8085 IN denotes by
T7207 8086-8087 DT denotes a
T7208 8097-8102 NN denotes arrow
T7209 8088-8096 JJ denotes vertical
T7210 8102-8103 . denotes .
T7211 8103-8275 sentence denotes Chicken β-globin exons 2 and 3 including the 3′UTR are indicated as black boxes with corresponding Roman numerals followed by the β-globin polyadenylation signal (PolyA*).
T7212 8104-8111 NN denotes Chicken
T7213 8127-8128 CD denotes 2
T7214 8112-8113 NN denotes β
T7215 8114-8120 NN denotes globin
T7216 8113-8114 HYPH denotes -
T7217 8121-8126 NNS denotes exons
T7218 8159-8168 VBN denotes indicated
T7219 8129-8132 CC denotes and
T7220 8133-8134 CD denotes 3
T7221 8135-8144 VBG denotes including
T7222 8145-8148 DT denotes the
T7223 8151-8154 NN denotes UTR
T7224 8149-8150 CD denotes 3
T7225 8150-8151 HYPH denotes ′
T7226 8155-8158 VBP denotes are
T7227 8169-8171 IN denotes as
T7228 8172-8177 JJ denotes black
T7229 8178-8183 NNS denotes boxes
T7230 8184-8188 IN denotes with
T7231 8189-8202 VBG denotes corresponding
T7232 8209-8217 NNS denotes numerals
T7233 8203-8208 NNP denotes Roman
T7234 8218-8226 VBN denotes followed
T7235 8227-8229 IN denotes by
T7236 8230-8233 DT denotes the
T7237 8259-8265 NN denotes signal
T7238 8234-8235 NN denotes β
T7239 8236-8242 NN denotes globin
T7240 8235-8236 HYPH denotes -
T7241 8243-8258 NN denotes polyadenylation
T7242 8266-8267 -LRB- denotes (
T7243 8267-8273 NN denotes PolyA*
T7244 8273-8274 -RRB- denotes )
T7245 8274-8275 . denotes .
T7246 8275-8436 sentence denotes For the Xpd†XP and Xpd†XPCS targeted alleles, vertical arrows indicate XPCS (G602D-encoding) and XP (R683W-encoding) mutations in exons 19 and 22, respectively.
T7247 8276-8279 IN denotes For
T7248 8338-8346 VBP denotes indicate
T7249 8280-8283 DT denotes the
T7250 8313-8320 NNS denotes alleles
T7251 8284-8290 NN denotes Xpd†XP
T7252 8291-8294 CC denotes and
T7253 8295-8303 NN denotes Xpd†XPCS
T7254 8304-8312 VBN denotes targeted
T7255 8320-8322 , denotes ,
T7256 8322-8330 JJ denotes vertical
T7257 8331-8337 NNS denotes arrows
T7258 8347-8351 NN denotes XPCS
T7259 8393-8402 NNS denotes mutations
T7260 8352-8353 -LRB- denotes (
T7261 8359-8367 VBG denotes encoding
T7262 8353-8358 NN denotes G602D
T7263 8358-8359 HYPH denotes -
T7264 8367-8368 -RRB- denotes )
T7265 8369-8372 CC denotes and
T7266 8373-8375 NN denotes XP
T7267 8376-8377 -LRB- denotes (
T7268 8383-8391 VBG denotes encoding
T7269 8377-8382 NN denotes R683W
T7270 8382-8383 HYPH denotes -
T7271 8391-8392 -RRB- denotes )
T7272 8403-8405 IN denotes in
T7273 8406-8411 NNS denotes exons
T7274 8412-8414 CD denotes 19
T7275 8415-8418 CC denotes and
T7276 8419-8421 CD denotes 22
T7277 8421-8423 , denotes ,
T7278 8423-8435 RB denotes respectively
T7279 8435-8436 . denotes .
T7280 8436-8529 sentence denotes The unique 3′ probe located outside the targeting construct is marked by a thick black line.
T7281 8437-8440 DT denotes The
T7282 8451-8456 NN denotes probe
T7283 8441-8447 JJ denotes unique
T7284 8448-8449 CD denotes 3
T7285 8449-8450 SYM denotes ′
T7286 8500-8506 VBN denotes marked
T7287 8457-8464 VBN denotes located
T7288 8465-8472 IN denotes outside
T7289 8473-8476 DT denotes the
T7290 8487-8496 NN denotes construct
T7291 8477-8486 VBG denotes targeting
T7292 8497-8499 VBZ denotes is
T7293 8507-8509 IN denotes by
T7294 8510-8511 DT denotes a
T7295 8524-8528 NN denotes line
T7296 8512-8517 JJ denotes thick
T7297 8518-8523 JJ denotes black
T7298 8528-8529 . denotes .
T7299 8529-8609 sentence denotes Restriction sites: B, BamHI; C, ClaI; E, EcoRI; H, HindIII; Hp, HpaI; Sf, SfiI.
T7300 8530-8541 NN denotes Restriction
T7301 8542-8547 NNS denotes sites
T7302 8547-8549 : denotes :
T7303 8549-8550 NN denotes B
T7304 8550-8552 , denotes ,
T7305 8552-8557 NN denotes BamHI
T7306 8557-8558 : denotes ;
T7307 8559-8560 NN denotes C
T7308 8560-8562 , denotes ,
T7309 8562-8566 NN denotes ClaI
T7310 8566-8567 : denotes ;
T7311 8568-8569 NN denotes E
T7312 8569-8571 , denotes ,
T7313 8571-8576 NN denotes EcoRI
T7314 8576-8577 : denotes ;
T7315 8578-8579 NN denotes H
T7316 8579-8581 , denotes ,
T7317 8581-8588 NN denotes HindIII
T7318 8588-8589 : denotes ;
T7319 8590-8592 NN denotes Hp
T7320 8592-8594 , denotes ,
T7321 8594-8598 NN denotes HpaI
T7322 8598-8599 : denotes ;
T7323 8600-8602 NN denotes Sf
T7324 8602-8604 , denotes ,
T7325 8604-8608 NN denotes SfiI
T7326 8608-8609 . denotes .
T7327 8609-8787 sentence denotes (B) Southern blot analysis of EcoRI-digested genomic DNA from wt, Xpd†XPCS/wt, and Xpd†XP/wt recombinant embryonic stem cell clones hybridised with the 3′ probe depicted in (A).
T7328 8610-8611 -LRB- denotes (
T7329 8611-8612 LS denotes B
T7330 8628-8636 NN denotes analysis
T7331 8612-8613 -RRB- denotes )
T7332 8614-8622 NNP denotes Southern
T7333 8623-8627 NN denotes blot
T7334 8637-8639 IN denotes of
T7335 8640-8645 NN denotes EcoRI
T7336 8646-8654 VBN denotes digested
T7337 8645-8646 HYPH denotes -
T7338 8663-8666 NN denotes DNA
T7339 8655-8662 JJ denotes genomic
T7340 8667-8671 IN denotes from
T7341 8672-8674 NN denotes wt
T7342 8735-8741 NNS denotes clones
T7343 8674-8676 , denotes ,
T7344 8676-8684 NN denotes Xpd†XPCS
T7345 8685-8687 NN denotes wt
T7346 8684-8685 HYPH denotes /
T7347 8687-8689 , denotes ,
T7348 8689-8692 CC denotes and
T7349 8693-8699 NN denotes Xpd†XP
T7350 8700-8702 NN denotes wt
T7351 8699-8700 HYPH denotes /
T7352 8703-8714 JJ denotes recombinant
T7353 8715-8724 JJ denotes embryonic
T7354 8730-8734 NN denotes cell
T7355 8725-8729 NN denotes stem
T7356 8742-8752 VBN denotes hybridised
T7357 8753-8757 IN denotes with
T7358 8758-8761 DT denotes the
T7359 8765-8770 NN denotes probe
T7360 8762-8763 CD denotes 3
T7361 8763-8764 SYM denotes ′
T7362 8771-8779 VBN denotes depicted
T7363 8780-8782 IN denotes in
T7364 8783-8784 -LRB- denotes (
T7365 8784-8785 NN denotes A
T7366 8785-8786 -RRB- denotes )
T7367 8786-8787 . denotes .
T7368 8787-8913 sentence denotes The wt allele yields a 6.5-kilobase (kb) fragment, whereas both targeted Xpd†XP and Xpd†XPCS alleles yield a 5.1-kb fragment.
T7369 8788-8791 DT denotes The
T7370 8795-8801 NN denotes allele
T7371 8792-8794 NN denotes wt
T7372 8802-8808 VBZ denotes yields
T7373 8809-8810 DT denotes a
T7374 8829-8837 NN denotes fragment
T7375 8811-8814 CD denotes 6.5
T7376 8815-8823 NN denotes kilobase
T7377 8814-8815 HYPH denotes -
T7378 8824-8825 -LRB- denotes (
T7379 8825-8827 NN denotes kb
T7380 8827-8828 -RRB- denotes )
T7381 8837-8839 , denotes ,
T7382 8839-8846 IN denotes whereas
T7383 8889-8894 VBP denotes yield
T7384 8847-8851 CC denotes both
T7385 8881-8888 NNS denotes alleles
T7386 8852-8860 VBN denotes targeted
T7387 8861-8867 NN denotes Xpd†XP
T7388 8868-8871 CC denotes and
T7389 8872-8880 NN denotes Xpd†XPCS
T7390 8895-8896 DT denotes a
T7391 8904-8912 NN denotes fragment
T7392 8897-8900 CD denotes 5.1
T7393 8901-8903 NN denotes kb
T7394 8900-8901 HYPH denotes -
T7395 8912-8913 . denotes .
T7396 8913-9064 sentence denotes (C) Genotyping of wt and targeted alleles by PCR using primers F2, R1, and mR as indicated in (A) yields fragments of 399 bp and 468 bp, respectively.
T7397 8914-8915 -LRB- denotes (
T7398 8915-8916 LS denotes C
T7399 8918-8928 NN denotes Genotyping
T7400 8916-8917 -RRB- denotes )
T7401 8929-8931 IN denotes of
T7402 8932-8934 NN denotes wt
T7403 8948-8955 NNS denotes alleles
T7404 8935-8938 CC denotes and
T7405 8939-8947 VBN denotes targeted
T7406 8956-8958 IN denotes by
T7407 8959-8962 NN denotes PCR
T7408 8963-8968 VBG denotes using
T7409 8969-8976 NNS denotes primers
T7410 8977-8979 NN denotes F2
T7411 8979-8981 , denotes ,
T7412 8981-8983 NN denotes R1
T7413 8983-8985 , denotes ,
T7414 8985-8988 CC denotes and
T7415 8989-8991 NN denotes mR
T7416 8992-8994 IN denotes as
T7417 8995-9004 VBN denotes indicated
T7418 9005-9007 IN denotes in
T7419 9008-9009 -LRB- denotes (
T7420 9009-9010 LS denotes A
T7421 9019-9028 NNS denotes fragments
T7422 9010-9011 -RRB- denotes )
T7423 9012-9018 VBZ denotes yields
T7424 9029-9031 IN denotes of
T7425 9032-9035 CD denotes 399
T7426 9036-9038 NN denotes bp
T7427 9039-9042 CC denotes and
T7428 9043-9046 CD denotes 468
T7429 9047-9049 NN denotes bp
T7430 9049-9051 , denotes ,
T7431 9051-9063 RB denotes respectively
T7432 9063-9064 . denotes .
T7433 9064-9308 sentence denotes (D) RT-PCR detection of mRNA expression originating from the targeted †XP and †XPCS alleles in embryonic stem cell clones using primers F1 (hybridising outside the targeting construct) and mR as indicated in (A) results in a 1,416-bp fragment.
T7434 9065-9066 -LRB- denotes (
T7435 9066-9067 LS denotes D
T7436 9277-9284 VBZ denotes results
T7437 9067-9068 -RRB- denotes )
T7438 9069-9071 NN denotes RT
T7439 9072-9075 NN denotes PCR
T7440 9071-9072 HYPH denotes -
T7441 9076-9085 NN denotes detection
T7442 9086-9088 IN denotes of
T7443 9089-9093 NN denotes mRNA
T7444 9094-9104 NN denotes expression
T7445 9105-9116 VBG denotes originating
T7446 9117-9121 IN denotes from
T7447 9122-9125 DT denotes the
T7448 9149-9156 NNS denotes alleles
T7449 9126-9134 VBN denotes targeted
T7450 9135-9138 NN denotes †XP
T7451 9139-9142 CC denotes and
T7452 9143-9148 NN denotes †XPCS
T7453 9157-9159 IN denotes in
T7454 9160-9169 JJ denotes embryonic
T7455 9175-9179 NN denotes cell
T7456 9170-9174 NN denotes stem
T7457 9180-9186 NNS denotes clones
T7458 9187-9192 VBG denotes using
T7459 9193-9200 NNS denotes primers
T7460 9201-9203 NN denotes F1
T7461 9204-9205 -LRB- denotes (
T7462 9205-9216 VBG denotes hybridising
T7463 9217-9224 IN denotes outside
T7464 9225-9228 DT denotes the
T7465 9239-9248 NN denotes construct
T7466 9229-9238 VBG denotes targeting
T7467 9248-9249 -RRB- denotes )
T7468 9250-9253 CC denotes and
T7469 9254-9256 NN denotes mR
T7470 9257-9259 IN denotes as
T7471 9260-9269 VBN denotes indicated
T7472 9270-9272 IN denotes in
T7473 9273-9274 -LRB- denotes (
T7474 9274-9275 NN denotes A
T7475 9275-9276 -RRB- denotes )
T7476 9285-9287 IN denotes in
T7477 9288-9289 DT denotes a
T7478 9299-9307 NN denotes fragment
T7479 9290-9295 CD denotes 1,416
T7480 9296-9298 NN denotes bp
T7481 9295-9296 HYPH denotes -
T7482 9307-9308 . denotes .
T7483 9308-9500 sentence denotes (E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD/TTD, heterozygous Xpd†XPCS/wt and XpdTTD/wt, and compound heterozygous Xpd†XPCS/TTD mice as indicated.
T7484 9309-9310 -LRB- denotes (
T7485 9310-9311 LS denotes E
T7486 9327-9335 NN denotes analysis
T7487 9311-9312 -RRB- denotes )
T7488 9313-9321 NNP denotes Northern
T7489 9322-9326 NN denotes blot
T7490 9336-9338 IN denotes of
T7491 9339-9344 JJ denotes total
T7492 9345-9348 NN denotes RNA
T7493 9349-9357 VBN denotes isolated
T7494 9358-9362 IN denotes from
T7495 9363-9369 NN denotes testis
T7496 9370-9372 IN denotes of
T7497 9373-9383 JJ denotes homozygous
T7498 9384-9386 NN denotes wt
T7499 9482-9486 NNS denotes mice
T7500 9387-9390 CC denotes and
T7501 9391-9397 NN denotes XpdTTD
T7502 9398-9401 NN denotes TTD
T7503 9397-9398 HYPH denotes /
T7504 9401-9403 , denotes ,
T7505 9403-9415 JJ denotes heterozygous
T7506 9425-9427 NN denotes wt
T7507 9416-9424 NN denotes Xpd†XPCS
T7508 9424-9425 HYPH denotes /
T7509 9428-9431 CC denotes and
T7510 9432-9438 NN denotes XpdTTD
T7511 9439-9441 NN denotes wt
T7512 9438-9439 HYPH denotes /
T7513 9441-9443 , denotes ,
T7514 9443-9446 CC denotes and
T7515 9447-9455 JJ denotes compound
T7516 9478-9481 NN denotes TTD
T7517 9456-9468 JJ denotes heterozygous
T7518 9469-9477 NN denotes Xpd†XPCS
T7519 9477-9478 HYPH denotes /
T7520 9487-9489 IN denotes as
T7521 9490-9499 VBN denotes indicated
T7522 9499-9500 . denotes .
T7523 9500-9638 sentence denotes Hybridisation with a 1.4-kb mouse Xpd cDNA probe detects mRNAs of 4, 3.3, and 2.7 kb from wt, Xpd†XPCS, and XpdTTD alleles, respectively.
T7524 9501-9514 NN denotes Hybridisation
T7525 9550-9557 VBZ denotes detects
T7526 9515-9519 IN denotes with
T7527 9520-9521 DT denotes a
T7528 9544-9549 NN denotes probe
T7529 9522-9525 CD denotes 1.4
T7530 9526-9528 NN denotes kb
T7531 9525-9526 HYPH denotes -
T7532 9529-9534 NN denotes mouse
T7533 9535-9538 NN denotes Xpd
T7534 9539-9543 NN denotes cDNA
T7535 9558-9563 NNS denotes mRNAs
T7536 9564-9566 IN denotes of
T7537 9567-9568 CD denotes 4
T7538 9583-9585 NN denotes kb
T7539 9568-9570 , denotes ,
T7540 9570-9573 CD denotes 3.3
T7541 9573-9575 , denotes ,
T7542 9575-9578 CC denotes and
T7543 9579-9582 CD denotes 2.7
T7544 9586-9590 IN denotes from
T7545 9591-9593 NN denotes wt
T7546 9616-9623 NNS denotes alleles
T7547 9593-9595 , denotes ,
T7548 9595-9603 NN denotes Xpd†XPCS
T7549 9603-9605 , denotes ,
T7550 9605-9608 CC denotes and
T7551 9609-9615 NN denotes XpdTTD
T7552 9623-9625 , denotes ,
T7553 9625-9637 RB denotes respectively
T7554 9637-9638 . denotes .
T7555 9638-9732 sentence denotes An ethidium bromide (EtBr)–stained gel showing the amount of total RNA loaded is shown below.
T7556 9639-9641 DT denotes An
T7557 9674-9677 NN denotes gel
T7558 9642-9650 NN denotes ethidium
T7559 9651-9658 NN denotes bromide
T7560 9666-9673 VBN denotes stained
T7561 9659-9660 -LRB- denotes (
T7562 9660-9664 NN denotes EtBr
T7563 9664-9665 -RRB- denotes )
T7564 9665-9666 HYPH denotes –
T7565 9720-9725 VBN denotes shown
T7566 9678-9685 VBG denotes showing
T7567 9686-9689 DT denotes the
T7568 9690-9696 NN denotes amount
T7569 9697-9699 IN denotes of
T7570 9700-9705 JJ denotes total
T7571 9706-9709 NN denotes RNA
T7572 9710-9716 VBN denotes loaded
T7573 9717-9719 VBZ denotes is
T7574 9726-9731 RB denotes below
T7575 9731-9732 . denotes .
T7658 11937-11944 JJ denotes Partial
T7659 11945-11951 NN denotes Rescue
T7660 11952-11954 IN denotes of
T7661 11955-11958 NN denotes TTD
T7662 11959-11968 JJ denotes Cutaneous
T7663 11968-11970 , denotes ,
T7664 11970-11975 NN denotes Blood
T7665 11975-11977 , denotes ,
T7666 11977-11980 CC denotes and
T7667 11981-11994 JJ denotes Developmental
T7668 11995-12005 NNS denotes Phenotypes
T7669 12006-12008 IN denotes in
T7670 12009-12017 NN denotes Compound
T7671 12044-12048 NNS denotes Mice
T7672 12018-12030 JJ denotes Heterozygous
T7673 12031-12037 NN denotes XpdTTD
T7674 12038-12043 NN denotes †XPCS
T7675 12037-12038 HYPH denotes /
T7676 12048-12148 sentence denotes (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice.
T7677 12049-12050 -LRB- denotes (
T7678 12050-12051 LS denotes A
T7679 12053-12064 NNS denotes Photographs
T7680 12051-12052 -RRB- denotes )
T7681 12065-12067 IN denotes of
T7682 12068-12069 CD denotes 5
T7683 12070-12072 NN denotes mo
T7684 12069-12070 HYPH denotes -
T7685 12073-12076 JJ denotes old
T7686 12072-12073 HYPH denotes -
T7687 12143-12147 NNS denotes mice
T7688 12077-12087 JJ denotes homozygous
T7689 12095-12098 NN denotes TTD
T7690 12088-12094 NN denotes XpdTTD
T7691 12094-12095 HYPH denotes /
T7692 12098-12100 , denotes ,
T7693 12100-12108 NN denotes compound
T7694 12129-12134 NN denotes †XPCS
T7695 12109-12121 JJ denotes heterozygous
T7696 12122-12128 NN denotes XpdTTD
T7697 12128-12129 HYPH denotes /
T7698 12134-12136 , denotes ,
T7699 12136-12139 CC denotes and
T7700 12140-12142 NN denotes wt
T7701 12147-12148 . denotes .
T7702 12148-12189 sentence denotes Insets: images of first-round hair loss.
T7703 12149-12155 NNS denotes Insets
T7704 12155-12157 : denotes :
T7705 12157-12163 NNS denotes images
T7706 12164-12166 IN denotes of
T7707 12167-12172 JJ denotes first
T7708 12173-12178 NN denotes round
T7709 12172-12173 HYPH denotes -
T7710 12184-12188 NN denotes loss
T7711 12179-12183 NN denotes hair
T7712 12188-12189 . denotes .
T7713 12189-12269 sentence denotes (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice.
T7714 12190-12191 -LRB- denotes (
T7715 12191-12192 LS denotes B
T7716 12207-12215 NN denotes analysis
T7717 12192-12193 -RRB- denotes )
T7718 12194-12206 JJ denotes Histological
T7719 12216-12218 IN denotes of
T7720 12219-12222 DT denotes the
T7721 12223-12227 NN denotes skin
T7722 12228-12230 IN denotes of
T7723 12231-12237 NN denotes XpdTTD
T7724 12238-12241 NN denotes TTD
T7725 12237-12238 HYPH denotes /
T7726 12264-12268 NNS denotes mice
T7727 12241-12243 , denotes ,
T7728 12243-12249 NN denotes XpdTTD
T7729 12250-12255 NN denotes †XPCS
T7730 12249-12250 HYPH denotes /
T7731 12255-12257 , denotes ,
T7732 12257-12260 CC denotes and
T7733 12261-12263 NN denotes wt
T7734 12268-12269 . denotes .
T7735 12269-12525 sentence denotes TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice.
T7736 12270-12273 NN denotes TTD
T7737 12274-12284 JJ denotes associated
T7738 12273-12274 HYPH denotes -
T7739 12285-12295 NN denotes acanthosis
T7740 12468-12472 VBD denotes were
T7741 12296-12297 -LRB- denotes (
T7742 12305-12314 NN denotes epidermis
T7743 12297-12304 JJR denotes thicker
T7744 12314-12316 , denotes ,
T7745 12316-12325 VBN denotes indicated
T7746 12326-12328 IN denotes by
T7747 12329-12334 JJ denotes solid
T7748 12344-12348 NN denotes line
T7749 12335-12343 JJ denotes vertical
T7750 12348-12349 -RRB- denotes )
T7751 12349-12351 , denotes ,
T7752 12351-12361 VBN denotes pronounced
T7753 12371-12376 NN denotes layer
T7754 12362-12370 JJ denotes granular
T7755 12377-12378 -LRB- denotes (
T7756 12378-12387 VBN denotes indicated
T7757 12388-12390 IN denotes by
T7758 12391-12397 NNS denotes arrows
T7759 12397-12398 -RRB- denotes )
T7760 12398-12400 , denotes ,
T7761 12400-12403 CC denotes and
T7762 12404-12413 JJ denotes sebacious
T7763 12420-12431 NN denotes hyperplasia
T7764 12414-12419 NN denotes gland
T7765 12432-12433 -LRB- denotes (
T7766 12433-12442 VBN denotes indicated
T7767 12443-12445 IN denotes by
T7768 12446-12452 VBN denotes dotted
T7769 12462-12466 NN denotes line
T7770 12453-12461 JJ denotes vertical
T7771 12466-12467 -RRB- denotes )
T7772 12473-12479 JJ denotes absent
T7773 12480-12482 IN denotes in
T7774 12483-12486 DT denotes the
T7775 12487-12496 NN denotes epidermis
T7776 12497-12499 IN denotes of
T7777 12500-12506 NN denotes XpdTTD
T7778 12507-12512 NN denotes †XPCS
T7779 12506-12507 HYPH denotes /
T7780 12520-12524 NNS denotes mice
T7781 12513-12516 CC denotes and
T7782 12517-12519 NN denotes wt
T7783 12524-12525 . denotes .
T7784 12525-12545 sentence denotes Magnification 400×.
T7785 12526-12539 NN denotes Magnification
T7786 12540-12543 CD denotes 400
T7787 12543-12544 SYM denotes ×
T7788 12544-12545 . denotes .
T7789 12545-12618 sentence denotes (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice.
T7790 12546-12547 -LRB- denotes (
T7791 12547-12548 LS denotes C
T7792 12559-12566 NN denotes content
T7793 12548-12549 -RRB- denotes )
T7794 12550-12558 NN denotes Cysteine
T7795 12567-12569 IN denotes of
T7796 12570-12574 NN denotes hair
T7797 12575-12579 IN denotes from
T7798 12580-12582 NN denotes wt
T7799 12613-12617 NNS denotes mice
T7800 12582-12584 , denotes ,
T7801 12584-12590 NN denotes XpdTTD
T7802 12591-12594 NN denotes TTD
T7803 12590-12591 HYPH denotes /
T7804 12594-12596 , denotes ,
T7805 12596-12599 CC denotes and
T7806 12600-12606 NN denotes XpdTTD
T7807 12607-12612 NN denotes †XPCS
T7808 12606-12607 HYPH denotes /
T7809 12617-12618 . denotes .
T7810 12618-12741 sentence denotes The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice.
T7811 12619-12622 DT denotes The
T7812 12625-12630 NN denotes value
T7813 12623-12624 NN denotes p
T7814 12624-12625 HYPH denotes -
T7815 12631-12640 VBZ denotes indicates
T7816 12641-12652 JJ denotes significant
T7817 12653-12664 NNS denotes differences
T7818 12665-12672 IN denotes between
T7819 12673-12680 NNS denotes mutants
T7820 12681-12684 CC denotes and
T7821 12685-12687 NN denotes wt
T7822 12687-12689 , denotes ,
T7823 12689-12691 RB denotes as
T7824 12697-12699 IN denotes as
T7825 12692-12696 RB denotes well
T7826 12700-12707 IN denotes between
T7827 12708-12714 NN denotes XpdTTD
T7828 12715-12718 NN denotes TTD
T7829 12714-12715 HYPH denotes /
T7830 12736-12740 NNS denotes mice
T7831 12719-12722 CC denotes and
T7832 12723-12729 NN denotes XpdTTD
T7833 12730-12735 NN denotes †XPCS
T7834 12729-12730 HYPH denotes /
T7835 12740-12741 . denotes .
T7836 12741-12795 sentence denotes Error bars indicate standard error of the mean (SEM).
T7837 12742-12747 NN denotes Error
T7838 12748-12752 NNS denotes bars
T7839 12753-12761 VBP denotes indicate
T7840 12762-12770 JJ denotes standard
T7841 12771-12776 NN denotes error
T7842 12777-12779 IN denotes of
T7843 12780-12783 DT denotes the
T7844 12784-12788 NN denotes mean
T7845 12789-12790 -LRB- denotes (
T7846 12790-12793 NN denotes SEM
T7847 12793-12794 -RRB- denotes )
T7848 12794-12795 . denotes .
T7849 12795-12865 sentence denotes (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice.
T7850 12796-12797 -LRB- denotes (
T7851 12797-12798 LS denotes D
T7852 12811-12817 NNS denotes values
T7853 12798-12799 -RRB- denotes )
T7854 12800-12810 NN denotes Hematocrit
T7855 12818-12822 IN denotes from
T7856 12823-12828 NN denotes blood
T7857 12829-12831 IN denotes of
T7858 12832-12838 NN denotes XpdTTD
T7859 12839-12842 NN denotes TTD
T7860 12838-12839 HYPH denotes /
T7861 12860-12864 NNS denotes mice
T7862 12843-12846 CC denotes and
T7863 12847-12853 NN denotes XpdTTD
T7864 12854-12859 NN denotes †XPCS
T7865 12853-12854 HYPH denotes /
T7866 12864-12865 . denotes .
T7867 12865-12938 sentence denotes The p-values indicate the significance of the difference relative to wt.
T7868 12866-12869 DT denotes The
T7869 12872-12878 NNS denotes values
T7870 12870-12871 NN denotes p
T7871 12871-12872 HYPH denotes -
T7872 12879-12887 VBP denotes indicate
T7873 12888-12891 DT denotes the
T7874 12892-12904 NN denotes significance
T7875 12905-12907 IN denotes of
T7876 12908-12911 DT denotes the
T7877 12912-12922 NN denotes difference
T7878 12923-12931 JJ denotes relative
T7879 12932-12934 IN denotes to
T7880 12935-12937 NN denotes wt
T7881 12937-12938 . denotes .
T7882 12938-12963 sentence denotes Error bars indicate SEM.
T7883 12939-12944 NN denotes Error
T7884 12945-12949 NNS denotes bars
T7885 12950-12958 VBP denotes indicate
T7886 12959-12962 NN denotes SEM
T7887 12962-12963 . denotes .
T7888 12963-13154 sentence denotes (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%).
T7889 12964-12965 -LRB- denotes (
T7890 12965-12966 LS denotes E
T7891 12973-12980 NNS denotes weights
T7892 12966-12967 -RRB- denotes )
T7893 12968-12972 NN denotes Body
T7894 12981-12983 IN denotes of
T7895 12984-12994 VBG denotes developing
T7896 13023-13027 NNS denotes mice
T7897 12995-13001 NN denotes XpdTTD
T7898 13002-13005 NN denotes TTD
T7899 13001-13002 HYPH denotes /
T7900 13006-13009 CC denotes and
T7901 13010-13016 NN denotes XpdTTD
T7902 13017-13022 NN denotes †XPCS
T7903 13016-13017 HYPH denotes /
T7904 13028-13033 IN denotes after
T7905 13034-13041 VBG denotes weaning
T7906 13042-13049 VBN denotes plotted
T7907 13050-13052 IN denotes as
T7908 13053-13054 DT denotes a
T7909 13055-13065 NN denotes percentage
T7910 13066-13068 IN denotes of
T7911 13069-13072 DT denotes the
T7912 13073-13079 NN denotes weight
T7913 13080-13082 IN denotes of
T7914 13083-13086 NN denotes age
T7915 13087-13094 JJ denotes matched
T7916 13086-13087 HYPH denotes -
T7917 13128-13139 NNS denotes littermates
T7918 13095-13102 NN denotes control
T7919 13103-13105 NN denotes wt
T7920 13106-13109 CC denotes and
T7921 13110-13122 NN denotes heterozygote
T7922 13123-13124 -LRB- denotes (
T7923 13124-13126 NN denotes hz
T7924 13126-13127 -RRB- denotes )
T7925 13140-13141 -LRB- denotes (
T7926 13141-13144 VBN denotes set
T7927 13145-13147 IN denotes at
T7928 13148-13151 CD denotes 100
T7929 13151-13152 NN denotes %
T7930 13152-13153 -RRB- denotes )
T7931 13153-13154 . denotes .
T7932 13154-13179 sentence denotes Error bars indicate SEM.
T7933 13155-13160 NN denotes Error
T7934 13161-13165 NNS denotes bars
T7935 13166-13174 VBP denotes indicate
T7936 13175-13178 NN denotes SEM
T7937 13178-13179 . denotes .
T8041 14852-14858 NN denotes Rescue
T8042 14859-14861 IN denotes of
T8043 14862-14865 NN denotes TTD
T8044 14866-14876 JJ denotes Associated
T8045 14865-14866 HYPH denotes -
T8046 14897-14905 NNS denotes Features
T8047 14877-14886 JJ denotes Segmental
T8048 14887-14896 JJ denotes Progeroid
T8049 14906-14908 IN denotes in
T8050 14909-14917 JJ denotes Compound
T8051 14945-14949 NNS denotes Mice
T8052 14918-14930 JJ denotes Heterozygous
T8053 14931-14938 NN denotes Xpd TTD
T8054 14939-14944 NN denotes †XPCS
T8055 14938-14939 HYPH denotes /
T8056 14949-15050 sentence denotes (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice.
T8057 14950-14951 -LRB- denotes (
T8058 14951-14952 LS denotes A
T8059 14954-14965 NNS denotes Photographs
T8060 14952-14953 -RRB- denotes )
T8061 14966-14968 IN denotes of
T8062 14969-14971 CD denotes 20
T8063 14972-14974 NN denotes mo
T8064 14971-14972 HYPH denotes -
T8065 14975-14978 JJ denotes old
T8066 14974-14975 HYPH denotes -
T8067 15045-15049 NNS denotes mice
T8068 14979-14981 NN denotes wt
T8069 14981-14983 , denotes ,
T8070 14983-14991 JJ denotes compound
T8071 15012-15017 NN denotes †XPCS
T8072 14992-15004 JJ denotes heterozygous
T8073 15005-15011 NN denotes XpdTTD
T8074 15011-15012 HYPH denotes /
T8075 15017-15019 , denotes ,
T8076 15019-15022 CC denotes and
T8077 15023-15033 JJ denotes homozygous
T8078 15041-15044 NN denotes TTD
T8079 15034-15040 NN denotes XpdTTD
T8080 15040-15041 HYPH denotes /
T8081 15049-15050 . denotes .
T8082 15050-15190 sentence denotes Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.
T8083 15051-15055 VB denotes Note
T8084 15056-15059 DT denotes the
T8085 15068-15076 NN denotes cachexia
T8086 15060-15067 JJ denotes extreme
T8087 15077-15078 -LRB- denotes (
T8088 15078-15082 NN denotes lack
T8089 15083-15085 IN denotes of
T8090 15086-15098 JJ denotes subcutaneous
T8091 15099-15102 NN denotes fat
T8092 15102-15103 -RRB- denotes )
T8093 15104-15106 IN denotes in
T8094 15107-15110 DT denotes the
T8095 15122-15127 NN denotes mouse
T8096 15111-15117 NN denotes XpdTTD
T8097 15118-15121 NN denotes TTD
T8098 15117-15118 HYPH denotes /
T8099 15128-15131 CC denotes and
T8100 15132-15135 DT denotes the
T8101 15136-15143 NN denotes absence
T8102 15144-15146 IN denotes of
T8103 15147-15151 DT denotes this
T8104 15152-15161 NN denotes phenotype
T8105 15162-15164 IN denotes in
T8106 15165-15167 NN denotes wt
T8107 15185-15189 NNS denotes mice
T8108 15168-15171 CC denotes and
T8109 15172-15178 NN denotes XpdTTD
T8110 15179-15184 NN denotes †XPCS
T8111 15178-15179 HYPH denotes /
T8112 15189-15190 . denotes .
T8113 15190-15263 sentence denotes (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice.
T8114 15191-15192 -LRB- denotes (
T8115 15192-15193 LS denotes B
T8116 15195-15206 NNS denotes Radiographs
T8117 15193-15194 -RRB- denotes )
T8118 15207-15209 IN denotes of
T8119 15210-15212 CD denotes 20
T8120 15213-15215 NN denotes mo
T8121 15212-15213 HYPH denotes -
T8122 15216-15219 JJ denotes old
T8123 15215-15216 HYPH denotes -
T8124 15258-15262 NNS denotes mice
T8125 15220-15224 JJ denotes male
T8126 15225-15227 NN denotes wt
T8127 15227-15229 , denotes ,
T8128 15229-15235 NN denotes XpdTTD
T8129 15236-15241 NN denotes †XPCS
T8130 15235-15236 HYPH denotes /
T8131 15241-15243 , denotes ,
T8132 15243-15246 CC denotes and
T8133 15247-15253 NN denotes XpdTTD
T8134 15254-15257 NN denotes TTD
T8135 15253-15254 HYPH denotes /
T8136 15262-15263 . denotes .
T8137 15263-15473 sentence denotes Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right).
T8138 15264-15270 VBG denotes Ageing
T8139 15282-15286 NNS denotes mice
T8140 15271-15277 NN denotes XpdTTD
T8141 15278-15281 NN denotes TTD
T8142 15277-15278 HYPH denotes /
T8143 15287-15294 VBP denotes develop
T8144 15295-15303 NN denotes kyphosis
T8145 15304-15305 -LRB- denotes (
T8146 15305-15314 NN denotes curvature
T8147 15315-15317 IN denotes of
T8148 15318-15321 DT denotes the
T8149 15329-15335 NN denotes column
T8150 15322-15328 JJ denotes spinal
T8151 15335-15336 -RRB- denotes )
T8152 15337-15340 CC denotes and
T8153 15341-15350 NN denotes reduction
T8154 15351-15353 IN denotes of
T8155 15354-15358 NN denotes bone
T8156 15359-15366 NN denotes mineral
T8157 15367-15374 NN denotes density
T8158 15375-15377 IN denotes as
T8159 15378-15383 VBN denotes shown
T8160 15384-15386 IN denotes in
T8161 15387-15390 DT denotes the
T8162 15395-15402 NN denotes segment
T8163 15391-15392 CD denotes 6
T8164 15393-15394 CD denotes 8
T8165 15392-15393 SYM denotes –
T8166 15403-15405 IN denotes of
T8167 15406-15409 DT denotes the
T8168 15415-15424 NNS denotes vertebrae
T8169 15410-15414 NN denotes tail
T8170 15425-15432 VBN denotes counted
T8171 15433-15437 IN denotes from
T8172 15438-15441 DT denotes the
T8173 15442-15448 NN denotes pelvis
T8174 15449-15450 -LRB- denotes (
T8175 15450-15453 VB denotes see
T8176 15454-15459 JJ denotes close
T8177 15459-15460 HYPH denotes -
T8178 15460-15462 RP denotes up
T8179 15463-15465 IN denotes at
T8180 15466-15471 NN denotes right
T8181 15471-15472 -RRB- denotes )
T8182 15472-15473 . denotes .
T8183 15473-15538 sentence denotes Note the absence of these features in the XpdTTD / † XPCS mouse.
T8184 15474-15478 VB denotes Note
T8185 15479-15482 DT denotes the
T8186 15483-15490 NN denotes absence
T8187 15491-15493 IN denotes of
T8188 15494-15499 DT denotes these
T8189 15500-15508 NNS denotes features
T8190 15509-15511 IN denotes in
T8191 15512-15515 DT denotes the
T8192 15532-15537 NN denotes mouse
T8193 15516-15523 NN denotes XpdTTD 
T8194 15524-15531 NN denotes  † XPCS
T8195 15523-15524 HYPH denotes /
T8196 15537-15538 . denotes .
T8197 15538-15691 sentence denotes (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice.
T8198 15539-15540 -LRB- denotes (
T8199 15540-15541 LS denotes C
T8200 15543-15557 NN denotes Quantification
T8201 15541-15542 -RRB- denotes )
T8202 15558-15560 IN denotes of
T8203 15561-15569 JJ denotes relative
T8204 15583-15590 NN denotes density
T8205 15570-15574 NN denotes bone
T8206 15575-15582 NN denotes mineral
T8207 15591-15593 IN denotes of
T8208 15594-15598 NN denotes tail
T8209 15599-15608 NNS denotes vertebrae
T8210 15609-15613 IN denotes from
T8211 15614-15616 CD denotes 20
T8212 15617-15619 NN denotes mo
T8213 15616-15617 HYPH denotes -
T8214 15620-15623 JJ denotes old
T8215 15619-15620 HYPH denotes -
T8216 15686-15690 NNS denotes mice
T8217 15624-15628 JJ denotes male
T8218 15629-15631 NN denotes wt
T8219 15632-15633 -LRB- denotes (
T8220 15637-15638 CD denotes 3
T8221 15633-15634 NN denotes n
T8222 15635-15636 SYM denotes =
T8223 15638-15639 -RRB- denotes )
T8224 15639-15641 , denotes ,
T8225 15641-15647 NN denotes XpdTTD
T8226 15648-15653 NN denotes †XPCS
T8227 15647-15648 HYPH denotes /
T8228 15654-15655 -LRB- denotes (
T8229 15659-15660 CD denotes 4
T8230 15655-15656 NN denotes n
T8231 15657-15658 SYM denotes =
T8232 15660-15661 -RRB- denotes )
T8233 15661-15663 , denotes ,
T8234 15663-15666 CC denotes and
T8235 15667-15673 NN denotes XpdTTD
T8236 15674-15677 NN denotes TTD
T8237 15673-15674 HYPH denotes /
T8238 15678-15679 -LRB- denotes (
T8239 15683-15684 CD denotes 3
T8240 15679-15680 NN denotes n
T8241 15681-15682 SYM denotes =
T8242 15684-15685 -RRB- denotes )
T8243 15690-15691 . denotes .
T8244 15691-15772 sentence denotes The p-values indicate the significance of the difference relative to XpdTTD/TTD.
T8245 15692-15695 DT denotes The
T8246 15698-15704 NNS denotes values
T8247 15696-15697 NN denotes p
T8248 15697-15698 HYPH denotes -
T8249 15705-15713 VBP denotes indicate
T8250 15714-15717 DT denotes the
T8251 15718-15730 NN denotes significance
T8252 15731-15733 IN denotes of
T8253 15734-15737 DT denotes the
T8254 15738-15748 NN denotes difference
T8255 15749-15757 JJ denotes relative
T8256 15758-15760 IN denotes to
T8257 15761-15767 NN denotes XpdTTD
T8258 15768-15771 NN denotes TTD
T8259 15767-15768 HYPH denotes /
T8260 15771-15772 . denotes .
T8261 15772-15797 sentence denotes Error bars indicate SEM.
T8262 15773-15778 NN denotes Error
T8263 15779-15783 NNS denotes bars
T8264 15784-15792 VBP denotes indicate
T8265 15793-15796 NN denotes SEM
T8266 15796-15797 . denotes .
T8267 15797-15843 sentence denotes (D) Body weight curves as a function of time.
T8268 15798-15799 -LRB- denotes (
T8269 15799-15800 LS denotes D
T8270 15814-15820 NNS denotes curves
T8271 15800-15801 -RRB- denotes )
T8272 15802-15806 NN denotes Body
T8273 15807-15813 NN denotes weight
T8274 15821-15823 IN denotes as
T8275 15824-15825 DT denotes a
T8276 15826-15834 NN denotes function
T8277 15835-15837 IN denotes of
T8278 15838-15842 NN denotes time
T8279 15842-15843 . denotes .
T8280 15843-15965 sentence denotes Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice.
T8281 15844-15848 VB denotes Note
T8282 15849-15853 IN denotes that
T8283 15913-15920 VBN denotes rescued
T8284 15854-15857 DT denotes the
T8285 15872-15880 NN denotes cachexia
T8286 15858-15861 NN denotes age
T8287 15862-15871 JJ denotes dependent
T8288 15861-15862 HYPH denotes -
T8289 15881-15889 VBN denotes observed
T8290 15890-15892 IN denotes in
T8291 15893-15899 NN denotes XpdTTD
T8292 15900-15903 NN denotes TTD
T8293 15899-15900 HYPH denotes /
T8294 15904-15908 NNS denotes mice
T8295 15909-15912 VBD denotes was
T8296 15921-15923 IN denotes in
T8297 15924-15928 CC denotes both
T8298 15929-15933 JJ denotes male
T8299 15960-15964 NNS denotes mice
T8300 15934-15937 CC denotes and
T8301 15938-15944 JJ denotes female
T8302 15945-15952 NN denotes XpdTTD 
T8303 15953-15959 NN denotes  †XPCS
T8304 15952-15953 HYPH denotes /
T8305 15964-15965 . denotes .
T8306 15965-16119 sentence denotes Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks.
T8307 15966-15977 JJ denotes Significant
T8308 15978-15989 NNS denotes differences
T8309 16062-16070 VBN denotes observed
T8310 15990-15997 IN denotes between
T8311 15998-16000 NN denotes wt
T8312 16001-16004 CC denotes and
T8313 16005-16011 NN denotes XpdTTD
T8314 16012-16015 NN denotes TTD
T8315 16011-16012 HYPH denotes /
T8316 16016-16019 CC denotes but
T8317 16020-16023 RB denotes not
T8318 16024-16031 IN denotes between
T8319 16032-16034 NN denotes wt
T8320 16052-16056 NNS denotes mice
T8321 16035-16038 CC denotes and
T8322 16039-16045 NN denotes XpdTTD
T8323 16046-16051 NN denotes †XPCS
T8324 16045-16046 HYPH denotes /
T8325 16057-16061 VBD denotes were
T8326 16071-16073 IN denotes at
T8327 16074-16075 CD denotes 9
T8328 16083-16085 NNS denotes mo
T8329 16076-16079 CC denotes and
T8330 16080-16082 CD denotes 18
T8331 16086-16088 IN denotes of
T8332 16089-16092 NN denotes age
T8333 16093-16095 IN denotes as
T8334 16096-16105 VBN denotes indicated
T8335 16106-16108 IN denotes by
T8336 16109-16118 NNS denotes asterisks
T8337 16118-16119 . denotes .
T8338 16119-16144 sentence denotes Error bars indicate SEM.
T8339 16120-16125 NN denotes Error
T8340 16126-16130 NNS denotes bars
T8341 16131-16139 VBP denotes indicate
T8342 16140-16143 NN denotes SEM
T8343 16143-16144 . denotes .
T8564 19446-19451 NN denotes TFIIH
T8565 19452-19461 NNS denotes Functions
T8566 19462-19465 CC denotes and
T8567 19466-19476 NNS denotes Mechanisms
T8568 19477-19479 IN denotes of
T8569 19480-19483 NN denotes XPD
T8570 19484-19494 VBN denotes Associated
T8571 19483-19484 HYPH denotes -
T8572 19503-19513 NN denotes Pleiotropy
T8573 19495-19502 NN denotes Disease
T8574 19513-19557 sentence denotes (A) Cellular survival after UV irradiation.
T8575 19514-19515 -LRB- denotes (
T8576 19515-19516 LS denotes A
T8577 19527-19535 NN denotes survival
T8578 19516-19517 -RRB- denotes )
T8579 19518-19526 JJ denotes Cellular
T8580 19536-19541 IN denotes after
T8581 19542-19544 NN denotes UV
T8582 19545-19556 NN denotes irradiation
T8583 19556-19557 . denotes .
T8584 19557-19683 sentence denotes Rescue of hemizygous XpdTTD/KO survival by Xpd†XPCS and Xpd†XP alleles is illustrated by arrows marked A and B, respectively.
T8585 19558-19564 NN denotes Rescue
T8586 19632-19643 VBN denotes illustrated
T8587 19565-19567 IN denotes of
T8588 19568-19578 JJ denotes hemizygous
T8589 19589-19597 NN denotes survival
T8590 19579-19585 NN denotes XpdTTD
T8591 19586-19588 NN denotes KO
T8592 19585-19586 HYPH denotes /
T8593 19598-19600 IN denotes by
T8594 19601-19609 NN denotes Xpd†XPCS
T8595 19621-19628 NNS denotes alleles
T8596 19610-19613 CC denotes and
T8597 19614-19620 NN denotes Xpd†XP
T8598 19629-19631 VBZ denotes is
T8599 19644-19646 IN denotes by
T8600 19647-19653 NNS denotes arrows
T8601 19654-19660 VBN denotes marked
T8602 19661-19662 NN denotes A
T8603 19663-19666 CC denotes and
T8604 19667-19668 NN denotes B
T8605 19668-19670 , denotes ,
T8606 19670-19682 RB denotes respectively
T8607 19682-19683 . denotes .
T8608 19683-19821 sentence denotes UV survival of homozygous XpdXPCS/XPCS cells (asterisk) from the normally expressed viable allele (XpdXPCS) is depicted by a dotted line.
T8609 19684-19686 NN denotes UV
T8610 19687-19695 NN denotes survival
T8611 19795-19803 VBN denotes depicted
T8612 19696-19698 IN denotes of
T8613 19699-19709 JJ denotes homozygous
T8614 19723-19728 NNS denotes cells
T8615 19710-19717 NN denotes XpdXPCS
T8616 19718-19722 NN denotes XPCS
T8617 19717-19718 HYPH denotes /
T8618 19729-19730 -LRB- denotes (
T8619 19730-19738 NN denotes asterisk
T8620 19738-19739 -RRB- denotes )
T8621 19740-19744 IN denotes from
T8622 19745-19748 DT denotes the
T8623 19775-19781 NN denotes allele
T8624 19749-19757 RB denotes normally
T8625 19758-19767 VBN denotes expressed
T8626 19768-19774 JJ denotes viable
T8627 19782-19783 -LRB- denotes (
T8628 19783-19790 NN denotes XpdXPCS
T8629 19790-19791 -RRB- denotes )
T8630 19792-19794 VBZ denotes is
T8631 19804-19806 IN denotes by
T8632 19807-19808 DT denotes a
T8633 19816-19820 NN denotes line
T8634 19809-19815 VBN denotes dotted
T8635 19820-19821 . denotes .
T8636 19821-19953 sentence denotes Survival curves represent an average of four independent experiments; 1–2 cell lines per genotype were included in each experiment.
T8637 19822-19830 NN denotes Survival
T8638 19831-19837 NNS denotes curves
T8639 19838-19847 VBP denotes represent
T8640 19925-19933 VBN denotes included
T8641 19848-19850 DT denotes an
T8642 19851-19858 NN denotes average
T8643 19859-19861 IN denotes of
T8644 19862-19866 CD denotes four
T8645 19879-19890 NNS denotes experiments
T8646 19867-19878 JJ denotes independent
T8647 19890-19891 : denotes ;
T8648 19892-19893 CD denotes 1
T8649 19894-19895 CD denotes 2
T8650 19893-19894 SYM denotes –
T8651 19901-19906 NNS denotes lines
T8652 19896-19900 NN denotes cell
T8653 19907-19910 IN denotes per
T8654 19911-19919 NN denotes genotype
T8655 19920-19924 VBD denotes were
T8656 19934-19936 IN denotes in
T8657 19937-19941 DT denotes each
T8658 19942-19952 NN denotes experiment
T8659 19952-19953 . denotes .
T8660 19953-19998 sentence denotes Error bars indicate SEM between experiments.
T8661 19954-19959 NN denotes Error
T8662 19960-19964 NNS denotes bars
T8663 19965-19973 VBP denotes indicate
T8664 19974-19977 NN denotes SEM
T8665 19978-19985 IN denotes between
T8666 19986-19997 NNS denotes experiments
T8667 19997-19998 . denotes .
T8668 19998-20045 sentence denotes (B) UV-UDS, a measure of global genome repair.
T8669 19999-20000 -LRB- denotes (
T8670 20000-20001 LS denotes B
T8671 20006-20009 NN denotes UDS
T8672 20001-20002 -RRB- denotes )
T8673 20003-20005 NN denotes UV
T8674 20005-20006 HYPH denotes -
T8675 20009-20011 , denotes ,
T8676 20011-20012 DT denotes a
T8677 20013-20020 NN denotes measure
T8678 20021-20023 IN denotes of
T8679 20024-20030 JJ denotes global
T8680 20038-20044 NN denotes repair
T8681 20031-20037 NN denotes genome
T8682 20044-20045 . denotes .
T8683 20045-20214 sentence denotes Number of experiments: n = 15 (XpdTTD/TTD), n = 6 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8684 20046-20052 NN denotes Number
T8685 20186-20194 VBN denotes included
T8686 20053-20055 IN denotes of
T8687 20056-20067 NNS denotes experiments
T8688 20067-20069 : denotes :
T8689 20069-20070 NN denotes n
T8690 20073-20075 CD denotes 15
T8691 20071-20072 SYM denotes =
T8692 20076-20077 -LRB- denotes (
T8693 20077-20083 NN denotes XpdTTD
T8694 20083-20084 SYM denotes /
T8695 20084-20087 NN denotes TTD
T8696 20087-20088 -RRB- denotes )
T8697 20088-20090 , denotes ,
T8698 20090-20091 NN denotes n
T8699 20094-20095 CD denotes 6
T8700 20092-20093 SYM denotes =
T8701 20096-20097 -LRB- denotes (
T8702 20104-20106 NN denotes KO
T8703 20097-20103 NN denotes XpdTTD
T8704 20103-20104 HYPH denotes /
T8705 20106-20107 -RRB- denotes )
T8706 20107-20109 , denotes ,
T8707 20109-20110 NN denotes n
T8708 20113-20114 CD denotes 4
T8709 20111-20112 SYM denotes =
T8710 20115-20116 -LRB- denotes (
T8711 20123-20128 NN denotes †XPCS
T8712 20116-20122 NN denotes XpdTTD
T8713 20122-20123 HYPH denotes /
T8714 20129-20130 -RRB- denotes )
T8715 20130-20132 , denotes ,
T8716 20132-20133 NN denotes n
T8717 20136-20137 CD denotes 2
T8718 20134-20135 SYM denotes =
T8719 20138-20139 -LRB- denotes (
T8720 20146-20149 NN denotes †XP
T8721 20139-20145 NN denotes XpdTTD
T8722 20145-20146 HYPH denotes /
T8723 20150-20151 -RRB- denotes )
T8724 20151-20152 : denotes ;
T8725 20153-20154 CD denotes 1
T8726 20155-20156 CD denotes 2
T8727 20154-20155 SYM denotes –
T8728 20162-20167 NNS denotes lines
T8729 20157-20161 NN denotes cell
T8730 20168-20171 IN denotes per
T8731 20172-20180 NN denotes genotype
T8732 20181-20185 VBD denotes were
T8733 20195-20197 IN denotes in
T8734 20198-20202 DT denotes each
T8735 20203-20213 NN denotes experiment
T8736 20213-20214 . denotes .
T8737 20214-20334 sentence denotes The asterisk indicates significant difference with XpdTTD/TTD; crosses indicate significant differences with XpdTTD/KO.
T8738 20215-20218 DT denotes The
T8739 20219-20227 NN denotes asterisk
T8740 20228-20237 VBZ denotes indicates
T8741 20286-20294 VBP denotes indicate
T8742 20238-20249 JJ denotes significant
T8743 20250-20260 NN denotes difference
T8744 20261-20265 IN denotes with
T8745 20266-20272 NN denotes XpdTTD
T8746 20273-20276 NN denotes TTD
T8747 20272-20273 HYPH denotes /
T8748 20276-20277 : denotes ;
T8749 20278-20285 NNS denotes crosses
T8750 20295-20306 JJ denotes significant
T8751 20307-20318 NNS denotes differences
T8752 20319-20323 IN denotes with
T8753 20324-20330 NN denotes XpdTTD
T8754 20331-20333 NN denotes KO
T8755 20330-20331 HYPH denotes /
T8756 20333-20334 . denotes .
T8757 20334-20411 sentence denotes (C) UV-RRS, a measure of transcription-coupled repair of UV-induced lesions.
T8758 20335-20336 -LRB- denotes (
T8759 20336-20337 LS denotes C
T8760 20342-20345 NN denotes RRS
T8761 20337-20338 -RRB- denotes )
T8762 20339-20341 NN denotes UV
T8763 20341-20342 HYPH denotes -
T8764 20345-20347 , denotes ,
T8765 20347-20348 DT denotes a
T8766 20349-20356 NN denotes measure
T8767 20357-20359 IN denotes of
T8768 20360-20373 NN denotes transcription
T8769 20374-20381 VBN denotes coupled
T8770 20373-20374 HYPH denotes -
T8771 20382-20388 NN denotes repair
T8772 20389-20391 IN denotes of
T8773 20392-20394 NN denotes UV
T8774 20395-20402 VBN denotes induced
T8775 20394-20395 HYPH denotes -
T8776 20403-20410 NNS denotes lesions
T8777 20410-20411 . denotes .
T8778 20411-20579 sentence denotes Number of experiments: n = 7 (XpdTTD/TTD), n = 2 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8779 20412-20418 NN denotes Number
T8780 20551-20559 VBN denotes included
T8781 20419-20421 IN denotes of
T8782 20422-20433 NNS denotes experiments
T8783 20433-20435 : denotes :
T8784 20435-20436 NN denotes n
T8785 20439-20440 CD denotes 7
T8786 20437-20438 SYM denotes =
T8787 20441-20442 -LRB- denotes (
T8788 20449-20452 NN denotes TTD
T8789 20442-20448 NN denotes XpdTTD
T8790 20448-20449 HYPH denotes /
T8791 20452-20453 -RRB- denotes )
T8792 20453-20455 , denotes ,
T8793 20455-20456 NN denotes n
T8794 20459-20460 CD denotes 2
T8795 20457-20458 SYM denotes =
T8796 20461-20462 -LRB- denotes (
T8797 20469-20471 NN denotes KO
T8798 20462-20468 NN denotes XpdTTD
T8799 20468-20469 HYPH denotes /
T8800 20471-20472 -RRB- denotes )
T8801 20472-20474 , denotes ,
T8802 20474-20475 NN denotes n
T8803 20478-20479 CD denotes 4
T8804 20476-20477 SYM denotes =
T8805 20480-20481 -LRB- denotes (
T8806 20488-20493 NN denotes †XPCS
T8807 20481-20487 NN denotes XpdTTD
T8808 20487-20488 HYPH denotes /
T8809 20494-20495 -RRB- denotes )
T8810 20495-20497 , denotes ,
T8811 20497-20498 NN denotes n
T8812 20501-20502 CD denotes 2
T8813 20499-20500 SYM denotes =
T8814 20503-20504 -LRB- denotes (
T8815 20511-20514 NN denotes †XP
T8816 20504-20510 NN denotes XpdTTD
T8817 20510-20511 HYPH denotes /
T8818 20515-20516 -RRB- denotes )
T8819 20516-20517 : denotes ;
T8820 20518-20519 CD denotes 1
T8821 20520-20521 CD denotes 2
T8822 20519-20520 SYM denotes –
T8823 20527-20532 NNS denotes lines
T8824 20522-20526 NN denotes cell
T8825 20533-20536 IN denotes per
T8826 20537-20545 NN denotes genotype
T8827 20546-20550 VBD denotes were
T8828 20560-20562 IN denotes in
T8829 20563-20567 DT denotes each
T8830 20568-20578 NN denotes experiment
T8831 20578-20579 . denotes .
T8832 20579-20686 sentence denotes (D) Incision/excision activity of combinations of altered TFIIH complexes in a reconstituted NER reaction.
T8833 20580-20581 -LRB- denotes (
T8834 20581-20582 LS denotes D
T8835 20602-20610 NN denotes activity
T8836 20582-20583 -RRB- denotes )
T8837 20584-20592 NN denotes Incision
T8838 20593-20601 NN denotes excision
T8839 20592-20593 HYPH denotes /
T8840 20611-20613 IN denotes of
T8841 20614-20626 NNS denotes combinations
T8842 20627-20629 IN denotes of
T8843 20630-20637 VBN denotes altered
T8844 20644-20653 NNS denotes complexes
T8845 20638-20643 NN denotes TFIIH
T8846 20654-20656 IN denotes in
T8847 20657-20658 DT denotes a
T8848 20677-20685 NN denotes reaction
T8849 20659-20672 VBN denotes reconstituted
T8850 20673-20676 NN denotes NER
T8851 20685-20686 . denotes .
T8852 20686-20940 sentence denotes Equal amounts of single or mixed populations of recombinant TFIIHs (containing XPD, XPB, p62, p52, His-p44, Flag-p34, cdk7, cyclin H, Mat1, and p8) were mixed with recombinant XPG, XPF/ERCC1, XPC/hHR23B, RPA, and a radiolabelled synthetic NER substrate.
T8853 20687-20692 JJ denotes Equal
T8854 20693-20700 NNS denotes amounts
T8855 20840-20845 VBN denotes mixed
T8856 20701-20703 IN denotes of
T8857 20704-20710 JJ denotes single
T8858 20720-20731 NNS denotes populations
T8859 20711-20713 CC denotes or
T8860 20714-20719 JJ denotes mixed
T8861 20732-20734 IN denotes of
T8862 20735-20746 JJ denotes recombinant
T8863 20747-20753 NNS denotes TFIIHs
T8864 20754-20755 -LRB- denotes (
T8865 20755-20765 VBG denotes containing
T8866 20766-20769 NN denotes XPD
T8867 20769-20771 , denotes ,
T8868 20771-20774 NN denotes XPB
T8869 20774-20776 , denotes ,
T8870 20776-20779 NN denotes p62
T8871 20779-20781 , denotes ,
T8872 20781-20784 NN denotes p52
T8873 20784-20786 , denotes ,
T8874 20786-20789 NN denotes His
T8875 20790-20793 NN denotes p44
T8876 20789-20790 HYPH denotes -
T8877 20793-20795 , denotes ,
T8878 20795-20799 NN denotes Flag
T8879 20800-20803 NN denotes p34
T8880 20799-20800 HYPH denotes -
T8881 20803-20805 , denotes ,
T8882 20805-20809 NN denotes cdk7
T8883 20809-20811 , denotes ,
T8884 20811-20817 NN denotes cyclin
T8885 20818-20819 NN denotes H
T8886 20819-20821 , denotes ,
T8887 20821-20825 NN denotes Mat1
T8888 20825-20827 , denotes ,
T8889 20827-20830 CC denotes and
T8890 20831-20833 NN denotes p8
T8891 20833-20834 -RRB- denotes )
T8892 20835-20839 VBD denotes were
T8893 20846-20850 IN denotes with
T8894 20851-20862 JJ denotes recombinant
T8895 20863-20866 NN denotes XPG
T8896 20866-20868 , denotes ,
T8897 20868-20871 NN denotes XPF
T8898 20872-20877 NN denotes ERCC1
T8899 20871-20872 HYPH denotes /
T8900 20877-20879 , denotes ,
T8901 20879-20882 NN denotes XPC
T8902 20883-20889 NN denotes hHR23B
T8903 20882-20883 HYPH denotes /
T8904 20889-20891 , denotes ,
T8905 20891-20894 NN denotes RPA
T8906 20894-20896 , denotes ,
T8907 20896-20899 CC denotes and
T8908 20900-20901 DT denotes a
T8909 20930-20939 NN denotes substrate
T8910 20902-20915 VBN denotes radiolabelled
T8911 20916-20925 JJ denotes synthetic
T8912 20926-20929 NN denotes NER
T8913 20939-20940 . denotes .
T8914 20940-21083 sentence denotes The excision products (26–34 nucleotides in length) were visualised at nucleotide resolution on a denaturing polyacrylamide gel as indicated .
T8915 20941-20944 DT denotes The
T8916 20954-20962 NNS denotes products
T8917 20945-20953 NN denotes excision
T8918 20998-21008 VBN denotes visualised
T8919 20963-20964 -LRB- denotes (
T8920 20970-20981 NNS denotes nucleotides
T8921 20964-20966 CD denotes 26
T8922 20967-20969 CD denotes 34
T8923 20966-20967 SYM denotes –
T8924 20982-20984 IN denotes in
T8925 20985-20991 NN denotes length
T8926 20991-20992 -RRB- denotes )
T8927 20993-20997 VBD denotes were
T8928 21009-21011 IN denotes at
T8929 21012-21022 NN denotes nucleotide
T8930 21023-21033 NN denotes resolution
T8931 21034-21036 IN denotes on
T8932 21037-21038 DT denotes a
T8933 21065-21068 NN denotes gel
T8934 21039-21049 VBG denotes denaturing
T8935 21050-21064 NN denotes polyacrylamide
T8936 21069-21071 IN denotes as
T8937 21072-21081 VBN denotes indicated
T8938 21082-21083 . denotes .
T8939 21083-21234 sentence denotes Note the weak activity corresponding to each single and combined TFIIH complex (lanes 3–8) relative to the wt (lane 1) and negative controls (lane 2).
T8940 21084-21088 VB denotes Note
T8941 21089-21092 DT denotes the
T8942 21098-21106 NN denotes activity
T8943 21093-21097 JJ denotes weak
T8944 21107-21120 VBG denotes corresponding
T8945 21121-21123 IN denotes to
T8946 21124-21128 DT denotes each
T8947 21155-21162 NN denotes complex
T8948 21129-21135 JJ denotes single
T8949 21136-21139 CC denotes and
T8950 21140-21148 VBN denotes combined
T8951 21149-21154 NN denotes TFIIH
T8952 21163-21164 -LRB- denotes (
T8953 21170-21171 CD denotes 3
T8954 21164-21169 NNS denotes lanes
T8955 21171-21172 SYM denotes –
T8956 21172-21173 CD denotes 8
T8957 21173-21174 -RRB- denotes )
T8958 21175-21183 JJ denotes relative
T8959 21184-21186 IN denotes to
T8960 21187-21190 DT denotes the
T8961 21191-21193 NN denotes wt
T8962 21194-21195 -LRB- denotes (
T8963 21195-21199 NN denotes lane
T8964 21200-21201 CD denotes 1
T8965 21201-21202 -RRB- denotes )
T8966 21203-21206 CC denotes and
T8967 21207-21215 JJ denotes negative
T8968 21216-21224 NNS denotes controls
T8969 21225-21226 -LRB- denotes (
T8970 21226-21230 NN denotes lane
T8971 21231-21232 CD denotes 2
T8972 21232-21233 -RRB- denotes )
T8973 21233-21234 . denotes .
T8974 21234-21447 sentence denotes (E) Xpd dose-dependent reduction of TFIIH in homozygous XpdTTD/TTD, hemizygous XpdTTD/KO, and compound heterozygous XpdTTD/†XPCS and XpdTTD/†XP cells by comparative immunofluorescence of the p62 subunit of TFIIH.
T8975 21235-21236 -LRB- denotes (
T8976 21236-21237 LS denotes E
T8977 21258-21267 NN denotes reduction
T8978 21237-21238 -RRB- denotes )
T8979 21239-21242 NN denotes Xpd
T8980 21243-21247 NN denotes dose
T8981 21248-21257 JJ denotes dependent
T8982 21247-21248 HYPH denotes -
T8983 21268-21270 IN denotes of
T8984 21271-21276 NN denotes TFIIH
T8985 21277-21279 IN denotes in
T8986 21280-21290 JJ denotes homozygous
T8987 21298-21301 NN denotes TTD
T8988 21291-21297 NN denotes XpdTTD
T8989 21297-21298 HYPH denotes /
T8990 21379-21384 NNS denotes cells
T8991 21301-21303 , denotes ,
T8992 21303-21313 JJ denotes hemizygous
T8993 21321-21323 NN denotes KO
T8994 21314-21320 NN denotes XpdTTD
T8995 21320-21321 HYPH denotes /
T8996 21323-21325 , denotes ,
T8997 21325-21328 CC denotes and
T8998 21329-21337 NN denotes compound
T8999 21358-21363 NN denotes †XPCS
T9000 21338-21350 JJ denotes heterozygous
T9001 21351-21357 NN denotes XpdTTD
T9002 21357-21358 HYPH denotes /
T9003 21364-21367 CC denotes and
T9004 21368-21374 NN denotes XpdTTD
T9005 21375-21378 NN denotes †XP
T9006 21374-21375 HYPH denotes /
T9007 21385-21387 IN denotes by
T9008 21388-21399 JJ denotes comparative
T9009 21400-21418 NN denotes immunofluorescence
T9010 21419-21421 IN denotes of
T9011 21422-21425 DT denotes the
T9012 21430-21437 NN denotes subunit
T9013 21426-21429 NN denotes p62
T9014 21438-21440 IN denotes of
T9015 21441-21446 NN denotes TFIIH
T9016 21446-21447 . denotes .
T9017 21447-21865 sentence denotes Roman numerals represent different microscopic slides and Arabic numerals different cell lines labelled as follows: (I) wt cells (1) labelled with 2-μm beads, XpdTTD/TTD cells (2) with 0.79-μm beads, and XpdTTD/KO cells (3) with no beads; (II) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XPCS cells (4) with no beads; and (III) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XP cells (5) with no beads.
T9018 21448-21453 JJ denotes Roman
T9019 21454-21462 NNS denotes numerals
T9020 21463-21472 VBP denotes represent
T9021 21473-21482 JJ denotes different
T9022 21495-21501 NNS denotes slides
T9023 21483-21494 JJ denotes microscopic
T9024 21502-21505 CC denotes and
T9025 21506-21512 JJ denotes Arabic
T9026 21513-21521 NNS denotes numerals
T9027 21537-21542 NNS denotes lines
T9028 21522-21531 JJ denotes different
T9029 21532-21536 NN denotes cell
T9030 21543-21551 VBN denotes labelled
T9031 21552-21554 IN denotes as
T9032 21555-21562 VBZ denotes follows
T9033 21562-21564 : denotes :
T9034 21564-21565 -LRB- denotes (
T9035 21565-21566 LS denotes I
T9036 21571-21576 NNS denotes cells
T9037 21566-21567 -RRB- denotes )
T9038 21568-21570 NN denotes wt
T9039 21577-21578 -LRB- denotes (
T9040 21578-21579 CD denotes 1
T9041 21579-21580 -RRB- denotes )
T9042 21581-21589 VBN denotes labelled
T9043 21590-21594 IN denotes with
T9044 21595-21596 CD denotes 2
T9045 21597-21599 NN denotes μm
T9046 21596-21597 HYPH denotes -
T9047 21600-21605 NNS denotes beads
T9048 21605-21607 , denotes ,
T9049 21607-21613 NN denotes XpdTTD
T9050 21614-21617 NN denotes TTD
T9051 21613-21614 HYPH denotes /
T9052 21618-21623 NNS denotes cells
T9053 21624-21625 -LRB- denotes (
T9054 21625-21626 CD denotes 2
T9055 21626-21627 -RRB- denotes )
T9056 21628-21632 IN denotes with
T9057 21633-21637 CD denotes 0.79
T9058 21638-21640 NN denotes μm
T9059 21637-21638 HYPH denotes -
T9060 21641-21646 NNS denotes beads
T9061 21646-21648 , denotes ,
T9062 21648-21651 CC denotes and
T9063 21652-21658 NN denotes XpdTTD
T9064 21659-21661 NN denotes KO
T9065 21658-21659 HYPH denotes /
T9066 21662-21667 NNS denotes cells
T9067 21668-21669 -LRB- denotes (
T9068 21669-21670 CD denotes 3
T9069 21670-21671 -RRB- denotes )
T9070 21672-21676 IN denotes with
T9071 21677-21679 DT denotes no
T9072 21680-21685 NNS denotes beads
T9073 21685-21686 : denotes ;
T9074 21687-21688 -LRB- denotes (
T9075 21688-21690 LS denotes II
T9076 21695-21700 NNS denotes cells
T9077 21690-21691 -RRB- denotes )
T9078 21692-21694 NN denotes wt
T9079 21701-21702 -LRB- denotes (
T9080 21702-21703 CD denotes 1
T9081 21703-21704 -RRB- denotes )
T9082 21705-21713 VBN denotes labelled
T9083 21714-21718 IN denotes with
T9084 21719-21723 CD denotes 0.79
T9085 21724-21726 NN denotes μm
T9086 21723-21724 HYPH denotes -
T9087 21727-21732 NNS denotes beads
T9088 21733-21736 CC denotes and
T9089 21737-21743 NN denotes XpdTTD
T9090 21744-21749 NN denotes †XPCS
T9091 21743-21744 HYPH denotes /
T9092 21750-21755 NNS denotes cells
T9093 21756-21757 -LRB- denotes (
T9094 21757-21758 CD denotes 4
T9095 21758-21759 -RRB- denotes )
T9096 21760-21764 IN denotes with
T9097 21765-21767 DT denotes no
T9098 21768-21773 NNS denotes beads
T9099 21773-21774 : denotes ;
T9100 21775-21778 CC denotes and
T9101 21779-21780 -LRB- denotes (
T9102 21780-21783 LS denotes III
T9103 21788-21793 NNS denotes cells
T9104 21783-21784 -RRB- denotes )
T9105 21785-21787 NN denotes wt
T9106 21794-21795 -LRB- denotes (
T9107 21795-21796 CD denotes 1
T9108 21796-21797 -RRB- denotes )
T9109 21798-21806 VBN denotes labelled
T9110 21807-21811 IN denotes with
T9111 21812-21816 CD denotes 0.79
T9112 21817-21819 NN denotes μm
T9113 21816-21817 HYPH denotes -
T9114 21820-21825 NNS denotes beads
T9115 21826-21829 CC denotes and
T9116 21830-21836 NN denotes XpdTTD
T9117 21837-21840 NN denotes †XP
T9118 21836-21837 HYPH denotes /
T9119 21841-21846 NNS denotes cells
T9120 21847-21848 -LRB- denotes (
T9121 21848-21849 CD denotes 5
T9122 21849-21850 -RRB- denotes )
T9123 21851-21855 IN denotes with
T9124 21856-21858 DT denotes no
T9125 21859-21864 NNS denotes beads
T9126 21864-21865 . denotes .
T9127 21865-21984 sentence denotes (F) Quantification of immunofluorescent signal from at least 50 nuclei per cell line and 2–6 experiments per genotype.
T9128 21866-21867 -LRB- denotes (
T9129 21867-21868 LS denotes F
T9130 21870-21884 NN denotes Quantification
T9131 21868-21869 -RRB- denotes )
T9132 21885-21887 IN denotes of
T9133 21888-21905 JJ denotes immunofluorescent
T9134 21906-21912 NN denotes signal
T9135 21913-21917 IN denotes from
T9136 21918-21920 RB denotes at
T9137 21927-21929 CD denotes 50
T9138 21921-21926 RBS denotes least
T9139 21930-21936 NNS denotes nuclei
T9140 21937-21940 IN denotes per
T9141 21941-21945 NN denotes cell
T9142 21946-21950 NN denotes line
T9143 21951-21954 CC denotes and
T9144 21955-21956 CD denotes 2
T9145 21957-21958 CD denotes 6
T9146 21956-21957 SYM denotes –
T9147 21959-21970 NNS denotes experiments
T9148 21971-21974 IN denotes per
T9149 21975-21983 NN denotes genotype
T9150 21983-21984 . denotes .
T9151 21984-22095 sentence denotes Bars representing cells analysed on the same microscopic slide are depicted side by side, with wt set at 100%.
T9152 21985-21989 NNS denotes Bars
T9153 22052-22060 VBN denotes depicted
T9154 21990-22002 VBG denotes representing
T9155 22003-22008 NNS denotes cells
T9156 22009-22017 VBN denotes analysed
T9157 22018-22020 IN denotes on
T9158 22021-22024 DT denotes the
T9159 22042-22047 NN denotes slide
T9160 22025-22029 JJ denotes same
T9161 22030-22041 JJ denotes microscopic
T9162 22048-22051 VBP denotes are
T9163 22061-22065 NN denotes side
T9164 22066-22068 IN denotes by
T9165 22069-22073 NN denotes side
T9166 22073-22075 , denotes ,
T9167 22075-22079 IN denotes with
T9168 22080-22082 NN denotes wt
T9169 22083-22086 VBN denotes set
T9170 22087-22089 IN denotes at
T9171 22090-22093 CD denotes 100
T9172 22093-22094 NN denotes %
T9173 22094-22095 . denotes .
T9174 22095-22250 sentence denotes The p-value indicates minimum significant difference between wt and the indicated cell lines analysed on the same microscopic slide within one experiment.
T9175 22096-22099 DT denotes The
T9176 22102-22107 NN denotes value
T9177 22100-22101 NN denotes p
T9178 22101-22102 HYPH denotes -
T9179 22108-22117 VBZ denotes indicates
T9180 22118-22125 JJ denotes minimum
T9181 22138-22148 NN denotes difference
T9182 22126-22137 JJ denotes significant
T9183 22149-22156 IN denotes between
T9184 22157-22159 NN denotes wt
T9185 22160-22163 CC denotes and
T9186 22164-22167 DT denotes the
T9187 22183-22188 NNS denotes lines
T9188 22168-22177 VBN denotes indicated
T9189 22178-22182 NN denotes cell
T9190 22189-22197 VBN denotes analysed
T9191 22198-22200 IN denotes on
T9192 22201-22204 DT denotes the
T9193 22222-22227 NN denotes slide
T9194 22205-22209 JJ denotes same
T9195 22210-22221 JJ denotes microscopic
T9196 22228-22234 IN denotes within
T9197 22235-22238 CD denotes one
T9198 22239-22249 NN denotes experiment
T9199 22249-22250 . denotes .
T9280 31591-31599 NN denotes Genotype
T9281 31600-31609 NN denotes Phenotype
T9282 31599-31600 HYPH denotes –
T9283 31610-31623 NNS denotes Relationships
T9284 31624-31626 IN denotes in
T9285 31627-31630 NN denotes XPD
T9286 31631-31640 NNS denotes Disorders
T9287 31640-31753 sentence denotes According to the current monoallelic hypothesis, phenotype is determined solely by the causative allele product.
T9288 31641-31650 VBG denotes According
T9289 31703-31713 VBN denotes determined
T9290 31651-31653 IN denotes to
T9291 31654-31657 DT denotes the
T9292 31678-31688 NN denotes hypothesis
T9293 31658-31665 JJ denotes current
T9294 31666-31677 JJ denotes monoallelic
T9295 31688-31690 , denotes ,
T9296 31690-31699 NN denotes phenotype
T9297 31700-31702 VBZ denotes is
T9298 31714-31720 RB denotes solely
T9299 31721-31723 IN denotes by
T9300 31724-31727 DT denotes the
T9301 31745-31752 NN denotes product
T9302 31728-31737 JJ denotes causative
T9303 31738-31744 NN denotes allele
T9304 31752-31753 . denotes .
T9305 31753-31831 sentence denotes If a second, different allele is present, it is considered a functional null.
T9306 31754-31756 IN denotes If
T9307 31784-31786 VBZ denotes is
T9308 31757-31758 DT denotes a
T9309 31777-31783 NN denotes allele
T9310 31759-31765 JJ denotes second
T9311 31765-31767 , denotes ,
T9312 31767-31776 JJ denotes different
T9313 31802-31812 VBN denotes considered
T9314 31787-31794 JJ denotes present
T9315 31794-31796 , denotes ,
T9316 31796-31798 PRP denotes it
T9317 31799-31801 VBZ denotes is
T9318 31813-31814 DT denotes a
T9319 31826-31830 NN denotes null
T9320 31815-31825 JJ denotes functional
T9321 31830-31831 . denotes .
T9322 31831-31931 sentence denotes There is a lack of any correlation between the site of the XPD mutation and the resulting disorder.
T9323 31832-31837 EX denotes There
T9324 31838-31840 VBZ denotes is
T9325 31841-31842 DT denotes a
T9326 31843-31847 NN denotes lack
T9327 31848-31850 IN denotes of
T9328 31851-31854 DT denotes any
T9329 31855-31866 NN denotes correlation
T9330 31867-31874 IN denotes between
T9331 31875-31878 DT denotes the
T9332 31879-31883 NN denotes site
T9333 31884-31886 IN denotes of
T9334 31887-31890 DT denotes the
T9335 31895-31903 NN denotes mutation
T9336 31891-31894 NN denotes XPD
T9337 31904-31907 CC denotes and
T9338 31908-31911 DT denotes the
T9339 31922-31930 NN denotes disorder
T9340 31912-31921 VBG denotes resulting
T9341 31930-31931 . denotes .
T9342 31931-32047 sentence denotes We propose a biallelic hypothesis for compound heterozygotes in which both alleles can contribute to the phenotype.
T9343 31932-31934 PRP denotes We
T9344 31935-31942 VBP denotes propose
T9345 31943-31944 DT denotes a
T9346 31955-31965 NN denotes hypothesis
T9347 31945-31954 JJ denotes biallelic
T9348 31966-31969 IN denotes for
T9349 31970-31978 NN denotes compound
T9350 31979-31992 NNS denotes heterozygotes
T9351 31993-31995 IN denotes in
T9352 32019-32029 VB denotes contribute
T9353 31996-32001 WDT denotes which
T9354 32002-32006 DT denotes both
T9355 32007-32014 NNS denotes alleles
T9356 32015-32018 MD denotes can
T9357 32030-32032 IN denotes to
T9358 32033-32036 DT denotes the
T9359 32037-32046 NN denotes phenotype
T9360 32046-32047 . denotes .
T9361 32047-32284 sentence denotes Examples of compound heterozygous patients in which a second, presumed null allele is likely to contribute to disease outcome are provided above in comparison to corresponding homo- or hemizygous patients with the same causative allele.
T9362 32048-32056 NNS denotes Examples
T9363 32178-32186 VBN denotes provided
T9364 32057-32059 IN denotes of
T9365 32060-32068 NN denotes compound
T9366 32082-32090 NNS denotes patients
T9367 32069-32081 JJ denotes heterozygous
T9368 32091-32093 IN denotes in
T9369 32131-32133 VBZ denotes is
T9370 32094-32099 WDT denotes which
T9371 32100-32101 DT denotes a
T9372 32124-32130 NN denotes allele
T9373 32102-32108 JJ denotes second
T9374 32108-32110 , denotes ,
T9375 32110-32118 JJ denotes presumed
T9376 32119-32123 JJ denotes null
T9377 32134-32140 JJ denotes likely
T9378 32141-32143 TO denotes to
T9379 32144-32154 VB denotes contribute
T9380 32155-32157 IN denotes to
T9381 32158-32165 NN denotes disease
T9382 32166-32173 NN denotes outcome
T9383 32174-32177 VBP denotes are
T9384 32187-32192 RB denotes above
T9385 32193-32195 IN denotes in
T9386 32196-32206 NN denotes comparison
T9387 32207-32209 IN denotes to
T9388 32210-32223 VBG denotes corresponding
T9389 32244-32252 NNS denotes patients
T9390 32224-32228 AFX denotes homo
T9391 32233-32243 JJ denotes hemizygous
T9392 32228-32229 HYPH denotes -
T9393 32230-32232 CC denotes or
T9394 32253-32257 IN denotes with
T9395 32258-32261 DT denotes the
T9396 32277-32283 NN denotes allele
T9397 32262-32266 JJ denotes same
T9398 32267-32276 JJ denotes causative
T9399 32283-32284 . denotes .
T9400 32284-32355 sentence denotes Numbers in the schematic of the protein indicate the helicase domains.
T9401 32285-32292 NNS denotes Numbers
T9402 32325-32333 VBP denotes indicate
T9403 32293-32295 IN denotes in
T9404 32296-32299 DT denotes the
T9405 32300-32309 NN denotes schematic
T9406 32310-32312 IN denotes of
T9407 32313-32316 DT denotes the
T9408 32317-32324 NN denotes protein
T9409 32334-32337 DT denotes the
T9410 32347-32354 NNS denotes domains
T9411 32338-32346 NN denotes helicase
T9412 32354-32355 . denotes .
T6770 35732-35743 JJ denotes Comparative
T6771 35744-35762 NN denotes immunofluorescence
T6772 35762-35763 . denotes .
T6773 35763-35965 sentence denotes Latex bead labelling and comparative immunofluorescence analysis of the p62 subunit of the TFIIH was performed as described previously [16,17] using primary mouse embryonic fibroblasts at passages 2–5.
T6774 35764-35769 NN denotes Latex
T6775 35775-35784 NN denotes labelling
T6776 35770-35774 NN denotes bead
T6777 35865-35874 VBN denotes performed
T6778 35785-35788 CC denotes and
T6779 35789-35800 JJ denotes comparative
T6780 35820-35828 NN denotes analysis
T9211 9742-9751 NN denotes Frequency
T9212 9752-9754 IN denotes of
T9213 9755-9761 NN denotes Xpd†XP
T9214 9762-9765 NN denotes †XP
T9215 9761-9762 HYPH denotes /
T9216 9765-9767 , denotes ,
T9217 9767-9775 NN denotes Xpd†XPCS
T9218 9776-9781 NN denotes †XPCS
T9219 9775-9776 HYPH denotes /
T9220 9781-9783 , denotes ,
T9221 9783-9786 CC denotes and
T9222 9787-9795 NN denotes Compound
T9223 9816-9821 NN denotes †XPCS
T9224 9796-9808 JJ denotes Heterozygous
T9225 9809-9815 NN denotes Xpd†XP
T9226 9815-9816 HYPH denotes /
T9227 9822-9829 NNS denotes Embryos
T9228 9830-9833 CC denotes and
T9229 9834-9843 NN denotes Offspring
T9241 16154-16165 JJ denotes Pleiotropic
T9242 16180-16187 NNS denotes Effects
T9243 16166-16169 NN denotes Xpd
T9244 16170-16179 JJ denotes Biallelic
T9245 16188-16190 IN denotes in
T9246 16191-16195 NNS denotes Mice
T9247 16196-16199 CC denotes and
T9248 16200-16205 NNS denotes Cells
T6781 35801-35819 NN denotes immunofluorescence
T6782 35829-35831 IN denotes of
T6783 35832-35835 DT denotes the
T6784 35840-35847 NN denotes subunit
T6785 35836-35839 NN denotes p62
T6786 35848-35850 IN denotes of
T6787 35851-35854 DT denotes the
T6788 35855-35860 NN denotes TFIIH
T6789 35861-35864 VBD denotes was
T6790 35875-35877 IN denotes as
T6791 35878-35887 VBN denotes described
T6792 35888-35898 RB denotes previously
T6793 35899-35900 -LRB- denotes [
T6794 35903-35905 CD denotes 17
T6795 35900-35902 CD denotes 16
T6796 35902-35903 , denotes ,
T6797 35905-35906 -RRB- denotes ]
T6798 35907-35912 VBG denotes using
T6799 35913-35920 JJ denotes primary
T6800 35937-35948 NNS denotes fibroblasts
T6801 35921-35926 NN denotes mouse
T6802 35927-35936 JJ denotes embryonic
T6803 35949-35951 IN denotes at
T6804 35952-35960 NNS denotes passages
T6805 35961-35962 CD denotes 2
T6806 35962-35963 SYM denotes –
T6807 35963-35964 CD denotes 5
T6808 35964-35965 . denotes .
T84 0-6 NN denotes Rescue
T85 0-74 sentence denotes Rescue of Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles
T2760 14710-14715 NN denotes †XPCS
T2761 14709-14710 HYPH denotes /
T2762 14721-14722 -LRB- denotes (
T2763 14729-14731 NN denotes 3A
T2764 14722-14728 NN denotes Figure
T2765 14732-14735 CC denotes and
T2766 14736-14738 NN denotes 3D
T2767 14738-14739 -RRB- denotes )
T2768 14739-14740 . denotes .
T2769 14740-14841 sentence denotes Finally, the life span of compound heterozygotes was extended relative to XpdTTD/TTD mice (Table 2).
T2770 14741-14748 RB denotes Finally
T2771 14794-14802 VBN denotes extended
T2772 14748-14750 , denotes ,
T2773 14750-14753 DT denotes the
T2774 14759-14763 NN denotes span
T2775 14754-14758 NN denotes life
T2776 14764-14766 IN denotes of
T2777 14767-14775 JJ denotes compound
T2778 14776-14789 NNS denotes heterozygotes
T2779 14790-14793 VBD denotes was
T2780 14803-14811 JJ denotes relative
T2781 14812-14814 IN denotes to
T2782 14815-14821 NN denotes XpdTTD
T2783 14822-14825 NN denotes TTD
T2784 14821-14822 HYPH denotes /
T2785 14826-14830 NNS denotes mice
T2786 14831-14832 -LRB- denotes (
T2787 14832-14837 NN denotes Table
T2788 14838-14839 CD denotes 2
T2789 14839-14840 -RRB- denotes )
T2790 14840-14841 . denotes .
T2791 14841-16451 sentence denotes Figure 3 Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice. (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse. (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM. (D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. Table 2 Pleiotropic Xpd Biallelic Effects in Mice and Cells To determine whether the homozygous lethal Xpd†XPCS allele was unique in its ability to ameliorate symptoms associated with the XpdTTD allele, we generated compound heterozygous XpdTTD/†XP mice by crossing the corresponding heterozygous animals.
T2792 16206-16208 TO denotes To
T2793 16209-16218 VB denotes determine
T2794 16352-16361 VBD denotes generated
T2795 16219-16226 IN denotes whether
T2796 16265-16268 VBD denotes was
T2797 16227-16230 DT denotes the
T2798 16258-16264 NN denotes allele
T2799 16231-16241 JJ denotes homozygous
T2800 16242-16248 JJ denotes lethal
T2801 16249-16257 NN denotes Xpd†XPCS
T2802 16269-16275 JJ denotes unique
T2803 16276-16278 IN denotes in
T2804 16279-16282 PRP$ denotes its
T2805 16283-16290 NN denotes ability
T2806 16291-16293 TO denotes to
T2807 16294-16304 VB denotes ameliorate
T2808 16305-16313 NNS denotes symptoms
T2809 16314-16324 VBN denotes associated
T2810 16325-16329 IN denotes with
T2811 16330-16333 DT denotes the
T2812 16341-16347 NN denotes allele
T2813 16334-16340 NN denotes XpdTTD
T2814 16347-16349 , denotes ,
T2815 16349-16351 PRP denotes we
T2816 16362-16370 NN denotes compound
T2817 16395-16399 NNS denotes mice
T2818 16371-16383 JJ denotes heterozygous
T2819 16384-16390 NN denotes XpdTTD
T2820 16391-16394 NN denotes †XP
T2821 16390-16391 HYPH denotes /
T2290 11706-11710 IN denotes than
T2291 11711-11713 IN denotes in
T2292 11714-11720 NN denotes XpdTTD
T2293 11721-11724 NN denotes TTD
T2294 11720-11721 HYPH denotes /
T2295 11725-11732 NNS denotes animals
T2296 11732-11734 , denotes ,
T2297 11734-11737 CC denotes but
T2298 11738-11746 VBD denotes remained
T2299 11747-11752 IN denotes below
T2300 11753-11756 DT denotes the
T2301 11760-11765 NN denotes level
T2302 11757-11759 NN denotes wt
T2303 11766-11767 -LRB- denotes (
T2304 11774-11776 NN denotes 2C
T2305 11767-11773 NN denotes Figure
T2306 11776-11777 -RRB- denotes )
T2307 11777-11778 . denotes .
T2308 11778-11926 sentence denotes TTD hemizygotes (XpdTTD/KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD/TTD mice [21].
T2309 11779-11782 NN denotes TTD
T2310 11783-11794 NNS denotes hemizygotes
T2311 11814-11821 VB denotes display
T2312 11795-11796 -LRB- denotes (
T2313 11803-11805 NN denotes KO
T2314 11796-11802 NN denotes XpdTTD
T2315 11802-11803 HYPH denotes /
T2316 11805-11806 -RRB- denotes )
T2317 11807-11809 VBP denotes do
T2318 11810-11813 RB denotes not
T2319 11822-11833 JJ denotes significant
T2320 11834-11845 NNS denotes differences
T2321 11846-11848 IN denotes in
T2322 11849-11858 JJ denotes cutaneous
T2323 11859-11867 NNS denotes features
T2324 11868-11871 CC denotes and
T2325 11872-11881 NN denotes longevity
T2326 11882-11890 JJ denotes relative
T2327 11891-11893 IN denotes to
T2328 11894-11904 JJ denotes homozygous
T2329 11916-11920 NNS denotes mice
T2330 11905-11911 NN denotes XpdTTD
T2331 11912-11915 NN denotes TTD
T2332 11911-11912 HYPH denotes /
T2333 11921-11922 -LRB- denotes [
T2334 11922-11924 CD denotes 21
T2335 11924-11925 -RRB- denotes ]
T2336 11925-11926 . denotes .
T2337 11926-13586 sentence denotes Figure 2 Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous XpdTTD/†XPCS Mice (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice. Insets: images of first-round hair loss. (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice. Magnification 400×. (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice. The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice. Error bars indicate standard error of the mean (SEM). (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice. The p-values indicate the significance of the difference relative to wt. Error bars indicate SEM. (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM. Other prominent TTD features in the epidermis, including acanthosis (thickening of the layer of the nucleated cells), hyperkeratosis (prominent thickening of the cornified layer), and pronounced granular layer and sebacious gland hyperplasia (causing greasy appearance of the hair), were absent in the skin of XpdTTD/†XPCS mice, as established by blind microscopic examination of skin sections (Figure 2B).
T2338 13180-13185 JJ denotes Other
T2339 13200-13208 NNS denotes features
T2340 13186-13195 JJ denotes prominent
T2341 13196-13199 NN denotes TTD
T2342 13463-13467 VBD denotes were
T2343 13209-13211 IN denotes in
T2344 13212-13215 DT denotes the
T2345 13216-13225 NN denotes epidermis
T2346 13225-13227 , denotes ,
T2347 13227-13236 VBG denotes including
T2348 13237-13247 NN denotes acanthosis
T2349 13248-13249 -LRB- denotes (
T2350 13249-13259 VBG denotes thickening
T2351 13260-13262 IN denotes of
T3736 19207-19215 RB denotes together
T3737 19215-19217 , denotes ,
T3738 19217-19222 DT denotes these
T3739 19223-19227 NNS denotes data
T3740 19232-19242 JJ denotes consistent
T3741 19243-19247 IN denotes with
T3742 19248-19260 JJ denotes interallelic
T3743 19261-19276 NN denotes complementation
T3744 19277-19279 IN denotes of
T3745 19280-19282 NN denotes UV
T3746 19283-19294 NN denotes sensitivity
T3747 19295-19297 IN denotes in
T3748 19298-19303 NNS denotes cells
T3749 19304-19307 CC denotes but
T3750 19308-19318 VBP denotes underscore
T3751 19319-19322 DT denotes the
T3752 19323-19327 NN denotes lack
T3753 19328-19330 IN denotes of
T3754 19331-19334 DT denotes any
T3755 19335-19346 NN denotes correlation
T3756 19347-19354 IN denotes between
T3757 19355-19357 NN denotes UV
T3758 19358-19365 VBN denotes related
T3759 19357-19358 HYPH denotes -
T3760 19373-19388 NNS denotes characteristics
T3761 19366-19372 NN denotes repair
T3762 19389-19392 CC denotes and
T3763 19393-19396 NN denotes TTD
T3764 19407-19417 NNS denotes phenotypes
T3765 19397-19406 NN denotes progeroid
T3766 19418-19420 IN denotes in
T3767 19421-19427 NN denotes animal
T3768 19428-19434 NNS denotes models
T3769 19434-19435 . denotes .
T3770 19435-19436 sentence denotes
T3771 22251-22260 sentence denotes Next we a
T3772 22251-22253 NN denotes Ne
T3773 22253-22255 NNS denotes xt
T3774 22255-22256 : denotes
T3775 22256-22258 VBD denotes we
T3776 22259-22260 DT denotes a
T3777 22260-22270 sentence denotes sked wheth
T3778 22260-22262 NN denotes sk
T3779 22262-22263 VBZ denotes e
T3780 22268-22269 VBP denotes t
T3781 22263-22264 NN denotes d
T3782 22265-22267 IN denotes wh
T3783 22267-22268 NNS denotes e
T3784 22269-22270 IN denotes h
T3785 22270-22274 sentence denotes er t
T3786 22270-22272 NN denotes er
T3787 22273-22274 NN denotes t
T3788 22274-22276 sentence denotes he
T3789 22274-22275 DT denotes h
T3790 22275-22276 NN denotes e
T3791 22276-22277 sentence denotes
T3792 22277-22280 sentence denotes Xpd
T3793 22277-22278 NN denotes X
T3794 22278-22279 NN denotes p
T3795 22279-22280 NN denotes d
T3796 22280-22299 sentence denotes †XPCS and Xpd†XP al
T3797 22280-22285 NN denotes †XPCS
T3798 22286-22289 CC denotes and
T3799 22290-22293 NN denotes Xpd
T3800 22293-22296 NN denotes †XP
T3801 22297-22298 JJ denotes a
T3802 22298-22299 NN denotes l
T3803 22299-22317 sentence denotes leles, despite dec
T3804 22299-22300 NNS denotes l
T3805 22300-22301 VBP denotes e
T3806 22301-22304 NNS denotes les
T3807 22304-22306 , denotes ,
T3808 22306-22307 NN denotes d
T3809 22307-22309 NNS denotes es
T3810 22309-22310 NN denotes p
T3811 22310-22312 IN denotes it
T3812 22312-22313 NNS denotes e
T3813 22314-22315 VBN denotes d
T3814 22315-22316 NNS denotes e
T3815 22316-22317 NNS denotes c
T3816 22317-22325 sentence denotes reased m
T3817 22317-22319 JJ denotes re
T3818 22319-22320 NN denotes a
T3819 22320-22321 RBS denotes s
T3820 22321-22322 NNS denotes e
T3821 22322-22323 CC denotes d
T3822 22324-22325 NNS denotes m
T3823 22325-22458 sentence denotes RNA levels, ameliorated TTD symptoms by increasing overall TFIIH levels in compound heterozygous XpdTTD/ †XPCS and XpdTTD/ †XP cells.
T3824 22337-22348 VBN denotes ameliorated
T3825 22329-22335 NNS denotes levels
T3826 22325-22328 NN denotes RNA
T3827 22335-22337 , denotes ,
T3828 22349-22352 NN denotes TTD
T3829 22353-22361 NNS denotes symptoms
T3830 22362-22364 IN denotes by
T3831 22365-22375 VBG denotes increasing
T3832 22390-22396 NNS denotes levels
T3833 22376-22383 JJ denotes overall
T3834 22384-22389 NN denotes TFIIH
T3835 22397-22399 IN denotes in
T3836 22400-22408 NN denotes compound
T3837 22452-22457 NNS denotes cells
T3838 22409-22421 JJ denotes heterozygous
T3839 22422-22428 NN denotes XpdTTD
T3840 22429-22435 NN denotes  †XPCS
T3841 22428-22429 HYPH denotes /
T3842 22436-22439 CC denotes and
T3843 22440-22446 NN denotes XpdTTD
T3844 22447-22451 NN denotes  †XP
T3845 22446-22447 HYPH denotes /
T3846 22457-22458 . denotes .
T3847 22458-22680 sentence denotes Previously, using comparative immunohistochemistry, we and others have shown an up to 70% reduction of TFIIH levels in primary fibroblasts from patients with TTD compared with wt controls due to reduced stability [16,17].
T3848 22459-22469 RB denotes Previously
T3849 22530-22535 VBN denotes shown
T3850 22469-22471 , denotes ,
T3851 22471-22476 VBG denotes using
T3852 22477-22488 JJ denotes comparative
T3853 22489-22509 NN denotes immunohistochemistry
T3854 22509-22511 , denotes ,
T3855 22511-22513 PRP denotes we
T3856 22514-22517 CC denotes and
T3857 22518-22524 NNS denotes others
T3858 22525-22529 VBP denotes have
T3859 22536-22538 DT denotes an
T3860 22549-22558 NN denotes reduction
T3861 22539-22541 IN denotes up
T3862 22545-22547 CD denotes 70
T3863 22542-22544 IN denotes to
T3864 22547-22548 NN denotes %
T3865 22559-22561 IN denotes of
T3866 22562-22567 NN denotes TFIIH
T3867 22568-22574 NNS denotes levels
T3868 22575-22577 IN denotes in
T3869 22578-22585 JJ denotes primary
T3870 22586-22597 NNS denotes fibroblasts
T3871 22598-22602 IN denotes from
T4084 23676-23682 JJ denotes normal
T4085 23682-23683 . denotes .
R7 T92 T90 pobj Alleles,by
R8 T93 T92 amod Lethal,Alleles
R9 T94 T92 compound Xpd,Alleles
R11 T97 T114 advcl is,documented
R12 T98 T99 compound compound,heterozygosity
R13 T99 T97 nsubj heterozygosity,is
R14 T100 T99 punct ", ",heterozygosity
R15 T101 T99 cc or,heterozygosity
R16 T102 T103 det the,presence
R17 T103 T99 conj presence,heterozygosity
R18 T104 T103 prep of,presence
R19 T105 T106 nummod two,alleles
R20 T106 T104 pobj alleles,of
R21 T107 T106 amod different,alleles
R22 T108 T106 amod mutant,alleles
R23 T109 T106 prep of,alleles
R24 T110 T111 det the,gene
R26 T112 T111 amod same,gene
R27 T113 T97 punct ", ",is
R31 T118 T116 pobj disease,in
R32 T119 T118 amod recessive,disease
R51 T140 T137 pobj difficulty,because
R52 T141 T140 amod inherent,difficulty
R56 T145 T143 dobj effects,distinguishing
R57 T146 T145 amod biallelic,effects
R71 T162 T160 pobj alleles,of
R72 T163 T162 amod recessive,alleles
R77 T168 T166 pobj pleiotropy,to
R78 T169 T168 amod enigmatic,pleiotropy
R82 T173 T171 pobj disorders,with
R83 T174 T173 amod recessive,disorders
R86 T177 T175 pobj models,in
R87 T178 T177 amod heterozygous,models
R88 T179 T177 compound mouse,models
R93 T186 T184 pobj helicase,in
R94 T187 T186 amod essential,helicase
R100 T193 T191 pobj repair,in
R101 T194 T193 compound DNA,repair
R112 T205 T203 pobj sensitivity,from
R113 T206 T205 compound UV,sensitivity
R119 T212 T210 pobj progeria,to
R120 T213 T212 amod segmental,progeria
R136 T231 T229 pobj alleles,of
R137 T232 T231 compound Xpd,alleles
R145 T240 T236 appos ability,following
R146 T241 T239 punct ),i
R147 T242 T240 det the,ability
R150 T245 T243 pobj alleles,of
R151 T246 T245 amod lethal,alleles
R152 T247 T245 compound Xpd,alleles
R161 T256 T249 advcl supplied,ameliorate
R162 T257 T258 poss their,function
R163 T258 T256 nsubjpass function,supplied
R164 T259 T258 amod essential,function
R165 T260 T258 amod basal,function
R166 T261 T258 compound transcription,function
R167 T262 T256 auxpass is,supplied
R170 T265 T263 pobj allele,by
R171 T266 T265 amod different,allele
R172 T267 T268 npadvmod disease,causing
R174 T269 T268 punct -,causing
R178 T273 T240 conj functions,ability
R179 T274 T272 punct ),ii
R180 T275 T276 amod differential,developmental
R181 T276 T273 amod developmental,functions
R182 T277 T276 cc and,developmental
R183 T278 T279 npadvmod tissue,specific
R185 T280 T279 punct -,specific
R188 T283 T281 pobj products,of
R189 T284 T285 compound Xpd,allele
R190 T285 T283 compound allele,products
R195 T290 T273 conj complementation,functions
R196 T291 T289 punct ),iii
R197 T292 T290 amod interallelic,complementation
R220 T317 T314 pobj alleles,of
R221 T318 T317 punct ”,alleles
R237 T334 T332 dobj plasticity,affect
R238 T335 T334 amod normal,plasticity
R239 T336 T335 cc and,normal
R240 T337 T335 conj pathological,normal
R241 T338 T334 amod phenotypic,plasticity
R246 T565 T566 amod Interallelic,complementation
R247 T566 T567 nsubjpass complementation,defined
R248 T568 T567 auxpass is,defined
R249 T569 T567 prep as,defined
R250 T570 T571 det the,ability
R251 T571 T569 pobj ability,as
R252 T572 T571 prep of,ability
R253 T573 T574 nummod two,alleles
R254 T574 T572 pobj alleles,of
R255 T575 T576 advmod differentially,mutated
R256 T576 T574 amod mutated,alleles
R257 T577 T578 aux to,function
R258 T578 T571 acl function,ability
R259 T579 T578 advmod better,function
R260 T580 T578 advmod together,function
R261 T581 T582 mark than,can
R263 T583 T582 nsubj either,can
R264 T584 T582 prep on,can
R265 T585 T586 poss its,own
R266 T586 T584 pobj own,on
R267 T587 T567 punct .,defined
R268 T589 T590 prep Despite,considered
R269 T591 T592 poss its,universality
R271 T593 T592 amod near,universality
R272 T594 T592 prep in,universality
R273 T595 T596 amod lower,organisms
R274 T596 T594 pobj organisms,in
R275 T597 T598 punct [,1
R276 T598 T596 parataxis 1,organisms
R277 T599 T598 punct ],1
R278 T600 T590 punct ", ",considered
R279 T601 T602 poss its,potential
R280 T602 T590 nsubjpass potential,considered
R281 T603 T604 aux to,contribute
R282 T604 T602 acl contribute,potential
R283 T605 T604 prep to,contribute
R284 T606 T607 amod clinical,heterogeneity
R285 T607 T605 pobj heterogeneity,to
R286 T608 T607 prep in,heterogeneity
R287 T609 T610 amod human,disease
R288 T610 T608 pobj disease,in
R289 T611 T590 auxpass is,considered
R290 T612 T590 advmod seldom,considered
R291 T613 T590 punct .,considered
R292 T615 T616 nsubjpass Evidence,limited
R293 T617 T615 prep of,Evidence
R294 T618 T619 amod interallelic,complementation
R295 T619 T617 pobj complementation,of
R296 T620 T619 prep at,complementation
R297 T621 T622 advmod clinically,relevant
R298 T622 T623 amod relevant,loci
R299 T623 T620 pobj loci,at
R300 T624 T616 auxpass is,limited
R301 T625 T616 prep to,limited
R302 T626 T627 amod biochemical,studies
R303 T627 T625 pobj studies,to
R304 T628 T626 cc and,biochemical
R305 T629 T630 npadvmod cell,based
R306 T630 T626 conj based,biochemical
R307 T631 T630 punct -,based
R308 T632 T627 prep of,studies
R309 T633 T634 det a,handful
R310 T634 T632 pobj handful,of
R311 T635 T634 prep of,handful
R312 T636 T637 amod metabolic,disorders
R313 T637 T635 pobj disorders,of
R314 T638 T637 prep with,disorders
R315 T639 T638 pobj defects,with
R316 T640 T639 prep in,defects
R317 T641 T640 pobj enzymes,in
R318 T642 T641 prep including,enzymes
R319 T643 T644 compound propinyl,CoA
R321 T645 T644 punct -,CoA
R322 T646 T642 pobj carboxylase,including
R323 T647 T648 punct [,2
R324 T648 T646 parataxis 2,carboxylase
R325 T649 T648 punct ],2
R326 T650 T646 punct ", ",carboxylase
R327 T651 T652 compound argininosuccinate,lyase
R328 T652 T646 conj lyase,carboxylase
R329 T653 T654 punct [,3
R330 T654 T652 parataxis 3,lyase
R331 T655 T654 punct ],3
R332 T656 T652 punct ", ",lyase
R333 T657 T658 nmod galactose,phosphate
R334 T658 T662 compound phosphate,uridylyltransferase
R335 T659 T658 punct -,phosphate
R336 T660 T658 nummod 1,phosphate
R337 T661 T658 punct -,phosphate
R338 T662 T652 conj uridylyltransferase,lyase
R339 T663 T664 punct [,4
R340 T664 T662 parataxis 4,uridylyltransferase
R341 T665 T664 punct ],4
R342 T666 T662 punct ", ",uridylyltransferase
R343 T667 T662 cc and,uridylyltransferase
R344 T668 T669 compound methylmalonyl,mutase
R346 T670 T669 compound CoA,mutase
R347 T671 T672 punct [,5
R348 T672 T669 parataxis 5,mutase
R349 T673 T672 punct ],5
R350 T674 T616 punct .,limited
R351 T676 T677 amod Compound,heterozygotes
R352 T677 T678 nsubj heterozygotes,are
R353 T679 T678 attr individuals,are
R354 T680 T679 acl carrying,individuals
R355 T681 T682 nummod two,alleles
R356 T682 T680 dobj alleles,carrying
R357 T683 T682 amod different,alleles
R358 T684 T682 amod mutant,alleles
R359 T685 T682 prep of,alleles
R360 T686 T687 det the,gene
R362 T688 T687 amod same,gene
R363 T689 T678 punct .,are
R364 T691 T692 prep In,result
R365 T693 T694 det the,absence
R366 T694 T691 pobj absence,In
R367 T695 T694 prep of,absence
R368 T696 T697 det a,allele
R369 T697 T695 pobj allele,of
R370 T698 T697 amod dominant,allele
R371 T699 T697 punct (,allele
R372 T700 T701 amod wild,type
R373 T701 T697 nmod type,allele
R374 T702 T701 punct -,type
R375 T703 T701 punct [,type
R376 T704 T701 appos wt,type
R377 T705 T697 punct ],allele
R378 T706 T697 punct ),allele
R379 T707 T692 punct ", ",result
R380 T708 T709 amod genetic,interactions
R381 T709 T692 nsubj interactions,result
R382 T710 T709 prep between,interactions
R383 T711 T712 amod recessive,alleles
R384 T712 T710 pobj alleles,between
R385 T713 T709 punct (,interactions
R386 T714 T709 acl referred,interactions
R387 T715 T714 prep to,referred
R388 T716 T714 advmod here,referred
R389 T717 T714 prep as,referred
R390 T718 T717 punct “,as
R391 T719 T720 amod biallelic,effects
R393 T721 T720 punct ”,effects
R394 T722 T692 punct ),result
R395 T723 T692 aux could,result
R396 T724 T692 prep in,result
R397 T725 T726 amod different,outcomes
R399 T727 T726 amod phenotypic,outcomes
R400 T728 T726 prep including,outcomes
R401 T729 T730 amod interallelic,complementation
R402 T730 T728 pobj complementation,including
R403 T731 T692 punct .,result
R404 T733 T734 mark Although,create
R405 T734 T743 advcl create,caused
R406 T735 T734 nsubj amelioration,create
R407 T736 T735 prep of,amelioration
R408 T737 T738 compound disease,symptoms
R409 T738 T736 pobj symptoms,of
R410 T739 T735 prep by,amelioration
R411 T740 T741 amod interallelic,complementation
R412 T741 T739 pobj complementation,by
R413 T742 T734 aux would,create
R414 T744 T745 det an,bias
R416 T746 T745 compound ascertainment,bias
R417 T747 T734 prep in,create
R418 T748 T749 det the,clinic
R419 T749 T747 pobj clinic,in
R420 T750 T743 punct ", ",caused
R421 T751 T752 det the,lack
R422 T752 T743 nsubjpass lack,caused
R423 T753 T752 prep of,lack
R424 T754 T753 pobj evidence,of
R425 T755 T754 prep concerning,evidence
R426 T756 T757 amod interallelic,complementation
R427 T757 T755 pobj complementation,concerning
R428 T758 T757 cc or,complementation
R429 T759 T760 amod other,effects
R431 T761 T760 amod biallelic,effects
R432 T762 T757 prep in,complementation
R433 T763 T764 amod human,disease
R434 T764 T762 pobj disease,in
R435 T765 T743 auxpass is,caused
R436 T766 T743 advmod likely,caused
R437 T767 T743 agent by,caused
R438 T768 T769 det the,difficulty
R439 T769 T767 pobj difficulty,by
R440 T770 T769 prep in,difficulty
R441 T771 T770 pcomp distinguishing,in
R442 T772 T773 amod such,effects
R443 T773 T771 dobj effects,distinguishing
R444 T774 T771 prep from,distinguishing
R445 T775 T774 pobj environment,from
R446 T776 T775 cc and,environment
R447 T777 T778 amod genetic,background
R448 T778 T775 conj background,environment
R449 T779 T743 punct .,caused
R450 T781 T782 nsubj XPD,encodes
R451 T783 T782 dobj one,encodes
R452 T784 T783 prep of,one
R453 T785 T786 det the,components
R454 T786 T784 pobj components,of
R455 T787 T786 nummod two,components
R456 T788 T786 compound helicase,components
R457 T789 T786 prep of,components
R458 T790 T791 amod basal,IIH
R459 T791 T789 pobj IIH,of
R460 T792 T791 nmod transcription,IIH
R461 T793 T792 punct /,transcription
R462 T794 T795 compound DNA,repair
R463 T795 T792 appos repair,transcription
R464 T796 T791 compound factor,IIH
R465 T797 T791 punct (,IIH
R466 T798 T791 appos TFIIH,IIH
R467 T799 T783 punct ),one
R468 T800 T783 punct ", ",one
R469 T801 T802 det a,complex
R470 T802 T783 appos complex,one
R471 T803 T804 nummod ten,subunit
R472 T804 T802 nmod subunit,complex
R473 T805 T804 punct -,subunit
R474 T806 T802 punct ", ",complex
R475 T807 T802 amod multifunctional,complex
R476 T808 T809 dep that,is
R477 T809 T802 relcl is,complex
R478 T810 T809 acomp essential,is
R479 T811 T810 prep for,essential
R480 T812 T813 amod multiple,processes
R481 T813 T811 pobj processes,for
R482 T814 T813 punct ", ",processes
R483 T815 T813 prep including,processes
R484 T816 T817 amod basal,initiation
R486 T818 T817 compound transcription,initiation
R487 T819 T817 cc and,initiation
R488 T820 T821 compound DNA,repair
R490 T822 T821 compound damage,repair
R491 T823 T821 prep via,repair
R492 T824 T825 det the,pathway
R493 T825 T823 pobj pathway,via
R494 T826 T827 nmod nucleotide,repair
R495 T827 T825 nmod repair,pathway
R496 T828 T827 nmod excision,repair
R497 T829 T827 punct (,repair
R498 T830 T827 appos NER,repair
R499 T831 T825 punct ),pathway
R500 T832 T833 punct [,7
R501 T833 T783 parataxis 7,one
R502 T834 T833 nummod 6,7
R503 T835 T833 punct ",",7
R504 T836 T833 punct ],7
R505 T837 T782 punct .,encodes
R506 T839 T840 nsubjpass Alterations,associated
R507 T841 T839 prep in,Alterations
R508 T842 T841 pobj XPD,in
R509 T843 T839 acl resulting,Alterations
R510 T844 T843 prep in,resulting
R511 T845 T846 amod defective,function
R513 T847 T846 compound TFIIH,function
R514 T848 T840 auxpass are,associated
R515 T849 T840 prep with,associated
R516 T850 T851 npadvmod UV,sensitive
R518 T852 T851 punct -,sensitive
R519 T853 T849 pobj disorders,with
R520 T854 T853 punct ", ",disorders
R521 T855 T853 amod multisystem,disorders
R522 T856 T853 prep including,disorders
R523 T857 T858 compound xeroderma,pigmentosum
R524 T858 T856 pobj pigmentosum,including
R525 T859 T858 punct (,pigmentosum
R526 T860 T858 appos XP,pigmentosum
R527 T861 T858 punct ),pigmentosum
R528 T862 T858 punct ", ",pigmentosum
R529 T863 T858 conj XP,pigmentosum
R530 T864 T863 acl combined,XP
R531 T865 T864 prep with,combined
R532 T866 T867 compound Cockayne,syndrome
R533 T867 T865 pobj syndrome,with
R534 T868 T867 punct (,syndrome
R535 T869 T867 appos CS,syndrome
R536 T870 T863 punct ),XP
R537 T871 T863 punct ", ",XP
R538 T872 T863 cc and,XP
R539 T873 T863 conj trichothiodystrophy,XP
R540 T874 T873 punct (,trichothiodystrophy
R541 T875 T873 appos TTD,trichothiodystrophy
R542 T876 T840 punct ),associated
R543 T877 T878 punct [,8
R544 T878 T840 parataxis 8,associated
R545 T879 T880 punct –,10
R546 T880 T878 prep 10,8
R547 T881 T878 punct ],8
R548 T882 T840 punct .,associated
R549 T884 T885 nsubjpass XP,marked
R550 T886 T885 auxpass is,marked
R551 T887 T885 agent by,marked
R552 T888 T889 npadvmod sun,induced
R554 T890 T889 punct -,induced
R556 T892 T891 compound pigmentation,anomalies
R557 T893 T891 cc and,anomalies
R558 T894 T895 det a,elevation
R559 T895 T891 conj elevation,anomalies
R560 T896 T897 amod greater,"1,000"
R561 T897 T899 quantmod "1,000",fold
R562 T898 T897 quantmod than,"1,000"
R563 T899 T895 nummod fold,elevation
R564 T900 T899 punct -,fold
R565 T901 T895 prep in,elevation
R566 T902 T903 compound skin,cancer
R567 T903 T904 compound cancer,risk
R568 T904 T901 pobj risk,in
R569 T905 T885 punct .,marked
R570 T907 T908 amod Severe,cases
R571 T908 T909 nsubj cases,present
R572 T910 T909 aux can,present
R573 T911 T909 advmod also,present
R574 T912 T909 prep with,present
R575 T913 T914 compound growth,retardation
R576 T914 T912 pobj retardation,with
R577 T915 T914 cc and,retardation
R578 T916 T917 amod primary,neurodegeneration
R579 T917 T914 conj neurodegeneration,retardation
R580 T918 T919 punct [,11
R581 T919 T909 parataxis 11,present
R582 T920 T919 punct ],11
R583 T921 T909 punct .,present
R584 T923 T924 nsubj CS,are
R585 T925 T923 cc and,CS
R586 T926 T923 conj TTD,CS
R587 T927 T924 punct ", ",are
R588 T928 T924 prep on,are
R589 T929 T930 det the,hand
R591 T931 T930 amod other,hand
R592 T932 T924 punct ", ",are
R593 T933 T934 amod segmental,disorders
R595 T935 T934 amod progeroid,disorders
R596 T936 T934 acl characterised,disorders
R597 T937 T936 agent by,characterised
R598 T938 T939 amod progressive,failure
R599 T939 T937 pobj failure,by
R600 T940 T939 amod post-natal,failure
R601 T941 T939 compound growth,failure
R602 T942 T939 cc and,failure
R603 T943 T944 amod primary,demyelination
R604 T944 T939 conj demyelination,failure
R605 T945 T944 acl resulting,demyelination
R606 T946 T945 prep in,resulting
R607 T947 T948 amod severe,neurodysfunction
R608 T948 T946 pobj neurodysfunction,in
R609 T949 T924 punct ", ",are
R610 T950 T951 cc but,without
R611 T951 T924 prep without,are
R612 T952 T953 det a,predisposition
R613 T953 T951 pobj predisposition,without
R614 T954 T953 amod clear,predisposition
R615 T955 T953 compound cancer,predisposition
R616 T956 T957 punct [,12
R617 T957 T924 parataxis 12,are
R618 T958 T959 punct –,15
R619 T959 T957 prep 15,12
R620 T960 T957 punct ],12
R621 T961 T924 punct .,are
R622 T963 T964 nsubj Patients,display
R623 T965 T963 prep with,Patients
R624 T966 T965 pobj TTD,with
R625 T967 T964 advmod additionally,display
R626 T968 T969 nmod hallmark,hair
R627 T969 T964 dobj hair,display
R628 T970 T971 npadvmod sulphur,deficient
R629 T971 T969 amod deficient,hair
R630 T972 T971 punct -,deficient
R631 T973 T969 amod brittle,hair
R632 T974 T969 cc and,hair
R633 T975 T969 conj nails,hair
R634 T976 T969 cc and,hair
R635 T977 T978 amod scaling,skin
R636 T978 T969 conj skin,hair
R637 T979 T980 punct [,13
R638 T980 T969 parataxis 13,hair
R639 T981 T980 punct ],13
R640 T982 T969 punct ", ",hair
R641 T983 T969 acl resulting,hair
R642 T984 T983 prep from,resulting
R643 T985 T986 det a,defect
R644 T986 T984 pobj defect,from
R645 T987 T986 amod basal,defect
R646 T988 T986 compound transcription,defect
R647 T989 T986 prep in,defect
R648 T990 T991 amod specific,types
R650 T992 T991 compound cell,types
R651 T993 T994 punct [,17
R652 T994 T964 parataxis 17,display
R653 T995 T994 nummod 16,17
R654 T996 T994 punct ",",17
R655 T997 T994 punct ],17
R656 T998 T964 punct .,display
R657 T1000 T1001 det A,disorder
R659 T1002 T1001 amod related,disorder
R660 T1004 T1001 prep with,disorder
R661 T1005 T1006 det the,predisposition
R663 T1007 T1006 compound cancer,predisposition
R664 T1008 T1006 prep of,predisposition
R665 T1009 T1008 pobj XP,of
R666 T1010 T1006 acl combined,predisposition
R667 T1011 T1010 prep with,combined
R668 T1012 T1013 det the,complications
R670 T1014 T1013 amod neurodevelopmental,complications
R671 T1015 T1013 prep of,complications
R672 T1016 T1015 pobj CS,of
R673 T1017 T1018 punct (,XPCS
R674 T1018 T1016 parataxis XPCS,CS
R675 T1019 T1018 punct ),XPCS
R676 T1020 T1003 punct ", ",described
R677 T1021 T1022 mark although,rare
R678 T1022 T1003 advcl rare,described
R679 T1023 T1003 punct ", ",described
R680 T1024 T1003 aux has,described
R681 T1025 T1003 advmod also,described
R682 T1026 T1003 auxpass been,described
R683 T1027 T1028 punct [,18
R684 T1028 T1003 parataxis 18,described
R685 T1029 T1028 punct ],18
R686 T1030 T1003 punct .,described
R687 T1032 T1033 amod Many,mutations
R689 T1034 T1033 compound XPD,mutations
R690 T1036 T1035 auxpass are,associated
R691 T1037 T1035 prep with,associated
R692 T1038 T1039 det an,phenotype
R693 T1039 T1037 pobj phenotype,with
R694 T1040 T1039 amod exclusive,phenotype
R695 T1041 T1039 compound disease,phenotype
R696 T1042 T1043 punct (,XPDR722W
R697 T1043 T1039 parataxis XPDR722W,phenotype
R698 T1044 T1043 advmod e.g.,XPDR722W
R699 T1045 T1043 punct ", ",XPDR722W
R700 T1046 T1043 prep with,XPDR722W
R701 T1047 T1046 pobj TTD,with
R702 T1048 T1043 cc and,XPDR722W
R703 T1049 T1043 conj XPDR683W,XPDR722W
R704 T1050 T1049 prep with,XPDR683W
R705 T1051 T1050 pobj XP,with
R706 T1052 T1043 punct ),XPDR722W
R707 T1053 T1035 cc and,associated
R708 T1054 T1055 auxpass are,viewed
R710 T1056 T1055 advmod thus,viewed
R711 T1057 T1055 prep as,viewed
R712 T1058 T1057 pobj causative,as
R713 T1059 T1058 prep of,causative
R714 T1060 T1061 det the,syndromes
R716 T1062 T1061 amod corresponding,syndromes
R717 T1063 T1035 punct .,associated
R718 T1065 T1066 nsubjpass Alleles,considered
R719 T1067 T1068 neg not,associated
R720 T1068 T1065 acl associated,Alleles
R721 T1069 T1068 advmod exclusively,associated
R722 T1070 T1068 prep with,associated
R723 T1071 T1072 nummod one,disorder
R724 T1072 T1070 pobj disorder,with
R725 T1073 T1066 auxpass are,considered
R726 T1074 T1075 punct “,alleles
R727 T1075 T1066 oprd alleles,considered
R728 T1076 T1077 advmod likely,null
R729 T1077 T1075 amod null,alleles
R730 T1078 T1075 punct ”,alleles
R731 T1079 T1080 punct [,20
R732 T1080 T1066 parataxis 20,considered
R733 T1081 T1080 nummod 19,20
R734 T1082 T1080 punct ",",20
R735 T1083 T1080 punct ],20
R736 T1084 T1066 punct .,considered
R737 T1086 T1087 nsubj Some,fail
R738 T1088 T1086 prep of,Some
R739 T1089 T1090 det these,alleles
R740 T1090 T1088 pobj alleles,of
R741 T1091 T1092 aux to,support
R742 T1092 T1087 xcomp support,fail
R743 T1093 T1092 dobj viability,support
R744 T1094 T1092 prep in,support
R745 T1095 T1096 det a,strain
R746 T1096 T1094 pobj strain,in
R747 T1097 T1096 amod haploid,strain
R748 T1098 T1096 compound Schizosaccharomyces,strain
R749 T1099 T1096 compound pombe,strain
R750 T1100 T1096 compound yeast,strain
R751 T1101 T1096 prep with,strain
R752 T1102 T1103 det a,mutation
R754 T1104 T1103 amod null,mutation
R755 T1105 T1103 prep in,mutation
R756 T1106 T1107 det the,rad15
R757 T1107 T1105 pobj rad15,in
R758 T1108 T1107 compound XPD,rad15
R759 T1109 T1107 compound homologue,rad15
R760 T1110 T1087 cc and,fail
R761 T1111 T1112 auxpass are,considered
R763 T1113 T1112 advmod thus,considered
R764 T1114 T1112 oprd devoid,considered
R765 T1115 T1114 prep of,devoid
R766 T1116 T1117 amod significant,activity
R768 T1118 T1117 amod biological,activity
R769 T1119 T1120 punct [,19
R770 T1120 T1112 parataxis 19,considered
R771 T1121 T1120 punct ],19
R772 T1122 T1087 punct .,fail
R773 T1124 T1125 det This,classification
R774 T1125 T1126 nsubj classification,defines
R775 T1127 T1125 prep of,classification
R776 T1128 T1127 pobj alleles,of
R777 T1129 T1125 prep as,classification
R778 T1130 T1131 preconj either,causative
R779 T1131 T1129 amod causative,as
R780 T1132 T1131 cc or,causative
R781 T1133 T1131 conj null,causative
R782 T1134 T1126 advmod currently,defines
R783 T1135 T1136 dep what,refer
R785 T1137 T1136 nsubj we,refer
R786 T1138 T1136 prep to,refer
R787 T1139 T1136 prep as,refer
R788 T1140 T1141 det a,paradigm
R789 T1141 T1139 pobj paradigm,as
R790 T1142 T1141 punct “,paradigm
R791 T1143 T1141 amod monoallelic,paradigm
R792 T1144 T1141 punct ”,paradigm
R793 T1145 T1141 prep of,paradigm
R794 T1146 T1147 compound XPD,disease
R795 T1147 T1145 pobj disease,of
R796 T1148 T1126 punct .,defines
R797 T1150 T1151 advmod However,casts
R798 T1152 T1151 punct ", ",casts
R799 T1153 T1154 det the,identification
R800 T1154 T1151 nsubj identification,casts
R801 T1155 T1154 prep in,identification
R802 T1156 T1157 amod recent,years
R803 T1157 T1155 pobj years,in
R804 T1158 T1157 prep of,years
R805 T1159 T1160 compound XP,patients
R806 T1160 T1158 pobj patients,of
R807 T1161 T1160 compound complementation,patients
R808 T1162 T1163 compound group,D
R809 T1163 T1160 compound D,patients
R810 T1164 T1160 prep with,patients
R811 T1165 T1166 amod atypical,presentation
R813 T1167 T1166 compound disease,presentation
R814 T1168 T1166 punct ", ",presentation
R815 T1169 T1166 prep including,presentation
R816 T1170 T1169 pobj symptoms,including
R817 T1171 T1170 prep of,symptoms
R818 T1172 T1173 preconj both,XP
R819 T1173 T1171 pobj XP,of
R820 T1174 T1173 cc and,XP
R821 T1175 T1173 conj TTD,XP
R822 T1176 T1177 punct [,8
R823 T1177 T1154 parataxis 8,identification
R824 T1178 T1177 punct ],8
R825 T1179 T1151 punct ", ",casts
R826 T1180 T1151 dobj doubt,casts
R827 T1181 T1151 prep on,casts
R828 T1182 T1183 det the,ability
R829 T1183 T1181 pobj ability,on
R830 T1184 T1183 prep of,ability
R831 T1185 T1186 amod such,paradigm
R832 T1186 T1184 pobj paradigm,of
R833 T1187 T1186 det a,paradigm
R834 T1188 T1186 amod monoallelic,paradigm
R835 T1189 T1190 aux to,explain
R836 T1190 T1183 acl explain,ability
R837 T1191 T1192 amod clinical,heterogeneity
R838 T1192 T1190 dobj heterogeneity,explain
R839 T1193 T1190 prep in,explain
R840 T1194 T1195 compound compound,heterozygotes
R841 T1195 T1193 pobj heterozygotes,in
R842 T1196 T1151 punct .,casts
R843 T1198 T1199 advmod Previously,generated
R844 T1200 T1199 punct ", ",generated
R845 T1201 T1199 nsubj we,generated
R846 T1202 T1203 det a,model
R847 T1203 T1199 dobj model,generated
R848 T1204 T1203 compound TTD,model
R849 T1205 T1203 compound mouse,model
R850 T1206 T1207 punct (,XPDR722W
R851 T1207 T1203 parataxis XPDR722W,model
R852 T1208 T1207 punct ),XPDR722W
R853 T1209 T1210 dep that,phenocopies
R854 T1210 T1203 relcl phenocopies,model
R855 T1211 T1212 det the,syndrome
R857 T1213 T1212 amod human,syndrome
R858 T1214 T1215 punct [,21
R859 T1215 T1199 parataxis 21,generated
R860 T1216 T1215 nummod 15,21
R861 T1217 T1215 punct ",",21
R862 T1218 T1215 punct ],21
R863 T1219 T1199 punct .,generated
R864 T1221 T1222 advmod Here,report
R865 T1223 T1222 nsubj we,report
R866 T1224 T1225 det the,generation
R867 T1225 T1222 dobj generation,report
R868 T1226 T1225 prep of,generation
R869 T1227 T1228 amod additional,alleles
R870 T1228 T1226 pobj alleles,of
R871 T1229 T1228 amod mutant,alleles
R872 T1230 T1228 compound Xpd,alleles
R873 T1231 T1232 dep that,fail
R874 T1232 T1228 relcl fail,alleles
R875 T1233 T1234 aux to,support
R876 T1234 T1232 xcomp support,fail
R877 T1235 T1234 dobj viability,support
R878 T1236 T1234 prep on,support
R879 T1237 T1238 poss their,own
R880 T1238 T1236 pobj own,on
R881 T1239 T1232 cc but,fail
R882 T1240 T1241 advmod nevertheless,ameliorate
R883 T1241 T1232 conj ameliorate,fail
R884 T1242 T1243 npadvmod TTD,associated
R886 T1244 T1243 punct -,associated
R887 T1245 T1241 dobj ageing,ameliorate
R888 T1246 T1245 amod premature,ageing
R889 T1247 T1245 amod segmental,ageing
R890 T1248 T1245 punct ", ",ageing
R891 T1249 T1250 amod cutaneous,features
R892 T1250 T1245 conj features,ageing
R893 T1251 T1250 punct ", ",features
R894 T1252 T1253 amod cellular,capacity
R895 T1253 T1250 conj capacity,features
R896 T1254 T1255 compound DNA,repair
R897 T1255 T1253 compound repair,capacity
R898 T1256 T1253 punct ", ",capacity
R899 T1257 T1253 cc and,capacity
R900 T1258 T1259 compound UV,survival
R901 T1259 T1253 conj survival,capacity
R902 T1260 T1261 advmod when,present
R903 T1261 T1241 advcl present,ameliorate
R904 T1262 T1261 prep in,present
R905 T1263 T1264 det a,state
R906 T1264 T1262 pobj state,in
R907 T1265 T1264 amod compound,state
R908 T1266 T1264 compound heterozygote,state
R909 T1267 T1222 punct .,report
R910 T1401 T1400 prep of,Generation
R911 T1402 T1403 compound Xpd,Heterozygotes
R913 T1404 T1403 compound Compound,Heterozygotes
R914 T1406 T1407 nsubj We,generated
R915 T1408 T1409 det an,allele
R916 T1409 T1407 dobj allele,generated
R917 T1410 T1409 nmod Xpd,allele
R918 T1411 T1409 amod knock,allele
R919 T1412 T1411 punct -,knock
R920 T1413 T1411 prt in,knock
R921 T1414 T1409 prep with,allele
R922 T1415 T1416 det a,mutation
R924 T1417 T1416 compound point,mutation
R925 T1418 T1416 acl encoding,mutation
R926 T1419 T1420 det a,change
R927 T1420 T1418 dobj change,encoding
R928 T1421 T1420 amod single,change
R929 T1422 T1423 compound amino,acid
R930 T1423 T1420 compound acid,change
R931 T1424 T1425 punct (,XPDG602D
R932 T1425 T1420 parataxis XPDG602D,change
R933 T1426 T1425 punct ),XPDG602D
R934 T1427 T1420 acl found,change
R935 T1428 T1427 prep in,found
R936 T1429 T1430 det the,patient
R938 T1431 T1430 compound XPCS,patient
R939 T1432 T1430 appos XPCS2,patient
R940 T1433 T1434 punct (,1A
R942 T1435 T1434 compound Figure,1A
R943 T1436 T1437 punct –,1C
R944 T1437 T1434 prep 1C,1A
R945 T1438 T1434 punct ),1A
R946 T1439 T1407 punct .,generated
R947 T1441 T1442 compound mRNA,expression
R948 T1442 T1443 nsubjpass expression,detected
R949 T1444 T1442 prep from,expression
R950 T1445 T1446 det the,allele
R952 T1447 T1446 amod targeted,allele
R953 T1448 T1443 aux could,detected
R954 T1449 T1443 auxpass be,detected
R955 T1450 T1443 prep in,detected
R956 T1451 T1452 amod embryonic,cells
R958 T1453 T1452 compound stem,cells
R959 T1454 T1443 prep by,detected
R960 T1455 T1456 compound RT,PCR
R962 T1457 T1456 punct -,PCR
R963 T1458 T1459 punct (,1D
R965 T1460 T1459 compound Figure,1D
R966 T1461 T1459 punct ),1D
R967 T1462 T1443 punct ", ",detected
R968 T1463 T1464 mark although,reduced
R969 T1464 T1443 advcl reduced,detected
R970 T1465 T1464 nsubjpass expression,reduced
R971 T1466 T1464 auxpass was,reduced
R972 T1467 T1468 advmod approximately,5
R973 T1468 T1464 npadvmod 5,reduced
R974 T1469 T1468 punct -,5
R975 T1470 T1468 advmod fold,5
R976 T1471 T1464 advcl relative,reduced
R977 T1472 T1471 prep to,relative
R978 T1473 T1474 compound wt,levels
R979 T1474 T1472 pobj levels,to
R980 T1475 T1474 compound mRNA,levels
R981 T1476 T1474 compound transcript,levels
R982 T1477 T1478 mark as,determined
R983 T1478 T1464 advcl determined,reduced
R984 T1479 T1478 prep by,determined
R985 T1480 T1479 pobj Northern,by
R986 T1481 T1480 amod blotting,Northern
R987 T1482 T1480 prep of,Northern
R988 T1483 T1482 pobj RNA,of
R989 T1484 T1483 prep from,RNA
R990 T1485 T1486 det the,testis
R991 T1486 T1484 pobj testis,from
R992 T1487 T1486 prep of,testis
R993 T1488 T1489 amod heterozygous,animals
R994 T1489 T1487 pobj animals,of
R995 T1490 T1491 punct (,1E
R997 T1492 T1491 compound Figure,1E
R998 T1493 T1491 punct ),1E
R999 T1494 T1443 punct .,detected
R1000 T1496 T1497 mark Because,was
R1001 T1497 T1500 advcl was,expected
R1002 T1498 T1499 compound patient,XPCS2
R1003 T1499 T1497 nsubj XPCS2,was
R1004 T1501 T1502 det a,hemizygote
R1005 T1502 T1497 attr hemizygote,was
R1006 T1503 T1502 prep with,hemizygote
R1007 T1504 T1505 amod mutant,protein
R1009 T1506 T1505 compound XPD,protein
R1010 T1507 T1508 punct (,XPDG602D
R1011 T1508 T1505 parataxis XPDG602D,protein
R1012 T1509 T1508 punct ),XPDG602D
R1013 T1510 T1505 acl expressed,protein
R1014 T1511 T1510 prep from,expressed
R1015 T1512 T1513 det a,allele
R1017 T1514 T1513 amod single,allele
R1018 T1515 T1500 punct ", ",expected
R1019 T1516 T1517 det the,mutation
R1021 T1518 T1517 amod corresponding,mutation
R1022 T1519 T1500 auxpass was,expected
R1023 T1520 T1521 aux to,be
R1024 T1521 T1500 xcomp be,expected
R1025 T1522 T1521 acomp viable,be
R1026 T1523 T1521 prep in,be
R1027 T1524 T1525 det the,state
R1029 T1526 T1525 amod homozygous,state
R1030 T1527 T1500 punct .,expected
R1031 T1529 T1530 advmod However,observed
R1032 T1531 T1530 punct ", ",observed
R1033 T1532 T1533 amod homozygous,mice
R1035 T1534 T1533 amod mutant,mice
R1036 T1535 T1530 auxpass were,observed
R1037 T1536 T1530 neg not,observed
R1038 T1537 T1530 punct ", ",observed
R1039 T1538 T1539 preconj neither,amongst
R1040 T1539 T1530 prep amongst,observed
R1041 T1540 T1541 amod live,births
R1042 T1541 T1539 pobj births,amongst
R1043 T1542 T1541 cc nor,births
R1044 T1543 T1544 amod embryonic,day
R1045 T1544 T1545 nmod day,embryos
R1046 T1545 T1541 conj embryos,births
R1047 T1546 T1544 nummod 13.5,day
R1048 T1547 T1544 punct (,day
R1049 T1548 T1544 appos E13.5,day
R1050 T1549 T1544 punct ),day
R1051 T1550 T1544 cc or,day
R1052 T1551 T1544 conj E3.5,day
R1053 T1552 T1553 punct (,Table
R1054 T1553 T1530 parataxis Table,observed
R1055 T1554 T1553 nummod 1,Table
R1056 T1555 T1553 punct ),Table
R1057 T1556 T1530 punct .,observed
R1058 T1558 T1559 det The,allele
R1059 T1559 T1564 nsubjpass allele,designated
R1060 T1560 T1559 amod corresponding,allele
R1061 T1561 T1559 amod hypomorphic,allele
R1062 T1562 T1559 punct ", ",allele
R1063 T1563 T1559 amod mutant,allele
R1064 T1565 T1564 auxpass was,designated
R1065 T1566 T1564 advmod thus,designated
R1066 T1567 T1564 prep as,designated
R1067 T1568 T1569 amod homozygous,lethal
R1068 T1569 T1567 pobj lethal,as
R1069 T1570 T1571 punct (,†XPCS
R1070 T1571 T1569 parataxis †XPCS,lethal
R1071 T1572 T1571 punct ),†XPCS
R1072 T1573 T1564 punct .,designated
R1073 T1575 T1576 amod Homozygous,lethality
R1074 T1576 T1577 nsubj lethality,is
R1075 T1578 T1576 prep of,lethality
R1076 T1579 T1580 det the,allele
R1078 T1581 T1580 compound XPCS,allele
R1079 T1582 T1583 advmod likely,due
R1080 T1583 T1577 prep due,is
R1081 T1584 T1583 prep to,due
R1082 T1585 T1586 amod reduced,levels
R1083 T1586 T1584 pobj levels,to
R1084 T1587 T1586 prep of,levels
R1085 T1588 T1587 pobj expression,of
R1086 T1589 T1588 prep of,expression
R1087 T1590 T1591 det this,protein
R1089 T1592 T1591 amod essential,protein
R1090 T1593 T1586 prep as,levels
R1091 T1594 T1595 det a,result
R1092 T1595 T1593 pobj result,as
R1093 T1596 T1595 prep of,result
R1094 T1597 T1598 compound gene,targeting
R1095 T1598 T1596 pobj targeting,of
R1096 T1599 T1600 punct (,1A
R1098 T1601 T1600 compound Figure,1A
R1099 T1602 T1600 punct ),1A
R1100 T1603 T1604 amod rather,than
R1101 T1604 T1584 cc than,to
R1102 T1605 T1584 conj to,to
R1103 T1606 T1607 det the,mutation
R1104 T1607 T1605 pobj mutation,to
R1105 T1608 T1607 appos itself,mutation
R1106 T1609 T1577 punct .,is
R1107 T1611 T1612 compound Xpd,ablation
R1108 T1612 T1613 nsubj ablation,is
R1109 T1614 T1615 punct (,KO
R1110 T1615 T1612 parataxis KO,ablation
R1111 T1616 T1615 compound XpdKO,KO
R1112 T1617 T1615 punct /,KO
R1113 T1618 T1615 punct ),KO
R1114 T1619 T1620 advmod similarly,incompatible
R1115 T1620 T1613 acomp incompatible,is
R1116 T1621 T1620 prep with,incompatible
R1117 T1622 T1621 pobj life,with
R1118 T1623 T1622 prep beyond,life
R1119 T1624 T1625 det the,stages
R1121 T1626 T1625 amod earliest,stages
R1122 T1627 T1625 prep of,stages
R1123 T1628 T1627 pobj embryogenesis,of
R1124 T1629 T1630 punct [,22
R1125 T1630 T1613 parataxis 22,is
R1126 T1631 T1630 punct ],22
R1127 T1632 T1613 punct .,is
R1128 T1634 T1635 advcl Consistent,was
R1129 T1636 T1634 prep with,Consistent
R1130 T1637 T1638 det this,interpretation
R1131 T1638 T1636 pobj interpretation,with
R1132 T1639 T1635 punct ", ",was
R1133 T1640 T1641 det a,mutation
R1134 T1641 T1635 nsubj mutation,was
R1135 T1642 T1641 amod different,mutation
R1136 T1643 T1641 amod targeted,mutation
R1137 T1644 T1641 compound Xpd,mutation
R1138 T1645 T1641 acl encoding,mutation
R1139 T1646 T1645 dobj XPDR683W,encoding
R1140 T1647 T1646 punct ", ",XPDR683W
R1141 T1648 T1649 dep which,associated
R1143 T1650 T1649 auxpass is,associated
R1144 T1651 T1649 prep with,associated
R1145 T1652 T1651 pobj XP,with
R1146 T1653 T1649 prep in,associated
R1147 T1654 T1655 det the,state
R1149 T1656 T1655 amod homozygous,state
R1150 T1657 T1649 prep in,associated
R1151 T1658 T1657 pobj humans,in
R1152 T1659 T1635 punct ", ",was
R1153 T1660 T1661 advmod similarly,underexpressed
R1154 T1661 T1635 acomp underexpressed,was
R1155 T1662 T1661 cc and,underexpressed
R1156 T1663 T1661 conj lethal,underexpressed
R1157 T1664 T1635 prep in,was
R1158 T1665 T1666 det the,state
R1160 T1667 T1666 amod homozygous,state
R1161 T1668 T1669 punct (,designated
R1162 T1669 T1635 parataxis designated,was
R1163 T1670 T1669 prep as,designated
R1164 T1671 T1672 compound †XP,allele
R1165 T1672 T1670 pobj allele,as
R1166 T1673 T1669 punct ),designated
R1167 T1674 T1675 punct (,1A
R1169 T1676 T1675 compound Figure,1A
R1170 T1677 T1678 punct –,1C
R1171 T1678 T1675 prep 1C,1A
R1172 T1679 T1675 punct ;,1A
R1173 T1680 T1675 appos Table,1A
R1174 T1681 T1680 nummod 1,Table
R1175 T1682 T1675 punct ;,1A
R1176 T1683 T1684 amod unpublished,data
R1177 T1684 T1675 appos data,1A
R1178 T1685 T1675 punct ),1A
R1179 T1686 T1635 punct .,was
R1180 T1688 T1689 advmod Also,resulted
R1181 T1690 T1689 punct ", ",resulted
R1182 T1691 T1692 det a,approach
R1183 T1692 T1689 nsubj approach,resulted
R1184 T1693 T1692 amod different,approach
R1185 T1694 T1692 compound targeting,approach
R1186 T1695 T1692 acl leading,approach
R1187 T1696 T1695 prep to,leading
R1188 T1697 T1698 det the,use
R1189 T1698 T1696 pobj use,to
R1190 T1699 T1698 prep of,use
R1191 T1700 T1701 det the,UTR
R1192 T1701 T1699 pobj UTR,of
R1193 T1702 T1701 amod native,UTR
R1194 T1703 T1701 nummod 3,UTR
R1195 T1704 T1703 punct ′,3
R1196 T1705 T1698 cc and,use
R1197 T1706 T1698 conj removal,use
R1198 T1707 T1706 prep of,removal
R1199 T1708 T1709 det the,gene
R1201 T1710 T1709 compound neo,gene
R1202 T1711 T1689 prep in,resulted
R1203 T1712 T1711 pobj normalisation,in
R1204 T1713 T1712 prep of,normalisation
R1205 T1714 T1715 compound XpdXPCS,levels
R1207 T1716 T1715 compound mRNA,levels
R1208 T1717 T1712 cc and,normalisation
R1209 T1718 T1719 amod viable,animals
R1210 T1719 T1712 conj animals,normalisation
R1211 T1720 T1719 amod homozygous,animals
R1212 T1721 T1722 nmod XpdXPCS,XPCS
R1213 T1722 T1719 nmod XPCS,animals
R1214 T1723 T1722 punct /,XPCS
R1215 T1724 T1725 punct (,G602D
R1217 T1726 T1725 compound XPDG602D,G602D
R1218 T1727 T1725 punct /,G602D
R1219 T1728 T1725 punct ),G602D
R1220 T1729 T1730 punct [,23
R1221 T1730 T1689 parataxis 23,resulted
R1222 T1731 T1730 punct ],23
R1223 T1732 T1689 punct .,resulted
R1226 T1954 T1955 punct “,Allele
R1227 T1955 T1958 nsubj Allele,Alleviate
R1228 T1956 T1955 amod Null,Allele
R1229 T1957 T1955 punct ”,Allele
R1230 T1959 T1958 aux Can,Alleviate
R1231 T1960 T1961 amod Developmental,Delay
R1232 T1961 T1958 dobj Delay,Alleviate
R1233 T1962 T1961 punct ", ",Delay
R1234 T1963 T1964 nmod Skin,Features
R1235 T1964 T1961 appos Features,Delay
R1236 T1965 T1963 punct ", ",Skin
R1237 T1966 T1963 cc and,Skin
R1238 T1967 T1963 conj Hair,Skin
R1239 T1968 T1964 prep of,Features
R1240 T1969 T1968 pobj TTD,of
R1241 T1971 T1972 aux To,test
R1242 T1972 T1973 advcl test,combined
R1243 T1974 T1975 det the,potential
R1244 T1975 T1972 dobj potential,test
R1245 T1976 T1975 prep of,potential
R1246 T1977 T1978 det a,allele
R1247 T1978 T1976 pobj allele,of
R1248 T1979 T1978 amod homozygous,allele
R1249 T1980 T1978 amod lethal,allele
R1250 T1981 T1978 punct “,allele
R1251 T1982 T1978 amod null,allele
R1252 T1983 T1978 punct ”,allele
R1253 T1984 T1985 aux to,contribute
R1254 T1985 T1975 acl contribute,potential
R1255 T1986 T1985 advmod nevertheless,contribute
R1256 T1987 T1985 prep to,contribute
R1257 T1988 T1989 amod organismal,phenotype
R1258 T1989 T1987 pobj phenotype,to
R1259 T1990 T1973 punct ", ",combined
R1260 T1991 T1973 nsubj we,combined
R1261 T1992 T1993 det an,allele
R1262 T1993 T1973 dobj allele,combined
R1263 T1994 T1993 compound Xpd†XPCS,allele
R1264 T1995 T1993 prep with,allele
R1265 T1996 T1997 det a,allele
R1266 T1997 T1995 pobj allele,with
R1267 T1998 T1997 amod viable,allele
R1268 T1999 T1997 compound XpdTTD,allele
R1269 T2000 T1973 prep by,combined
R1270 T2001 T2000 pcomp crossing,by
R1271 T2002 T2003 det the,animals
R1272 T2003 T2001 dobj animals,crossing
R1273 T2004 T2003 amod corresponding,animals
R1274 T2005 T2003 amod heterozygous,animals
R1275 T2006 T1973 punct .,combined
R1276 T2008 T2009 advcl Similar,born
R1277 T2010 T2008 prep to,Similar
R1278 T2011 T2012 amod hemizygous,mice
R1279 T2012 T2010 pobj mice,to
R1280 T2013 T2012 compound TTD,mice
R1281 T2014 T2012 acl carrying,mice
R1282 T2015 T2016 nummod one,allele
R1283 T2016 T2014 dobj allele,carrying
R1284 T2017 T2016 amod true,allele
R1285 T2018 T2019 compound Xpd,knockout
R1286 T2019 T2016 compound knockout,allele
R1287 T2020 T2021 punct (,KO
R1288 T2021 T2016 parataxis KO,allele
R1289 T2022 T2021 compound XpdTTD,KO
R1290 T2023 T2021 punct /,KO
R1291 T2024 T2021 punct ),KO
R1292 T2025 T2009 punct ", ",born
R1293 T2026 T2027 nmod compound,mice
R1294 T2027 T2009 nsubjpass mice,born
R1295 T2028 T2027 amod heterozygous,mice
R1296 T2029 T2030 compound XpdTTD,†XPCS
R1297 T2030 T2027 compound †XPCS,mice
R1298 T2031 T2030 punct /,†XPCS
R1299 T2032 T2009 auxpass were,born
R1300 T2033 T2009 prep at,born
R1301 T2034 T2035 det the,frequencies
R1302 T2035 T2033 pobj frequencies,at
R1303 T2036 T2035 amod expected,frequencies
R1304 T2037 T2035 amod Mendelian,frequencies
R1305 T2038 T2009 punct .,born
R1306 T2040 T2041 nsubjpass Expression,reduced
R1307 T2042 T2040 prep from,Expression
R1308 T2043 T2044 det the,allele
R1309 T2044 T2042 pobj allele,from
R1310 T2045 T2044 compound Xpd†XPCS,allele
R1311 T2046 T2041 auxpass was,reduced
R1312 T2047 T2041 advmod also,reduced
R1313 T2048 T2041 prep in,reduced
R1314 T2049 T2050 det the,testis
R1315 T2050 T2048 pobj testis,in
R1316 T2051 T2050 prep of,testis
R1317 T2052 T2053 nmod compound,animals
R1318 T2053 T2051 pobj animals,of
R1319 T2054 T2053 amod heterozygous,animals
R1320 T2055 T2041 punct ", ",reduced
R1321 T2056 T2057 mark whereas,increased
R1322 T2057 T2041 advcl increased,reduced
R1323 T2058 T2057 nsubjpass expression,increased
R1324 T2059 T2058 prep from,expression
R1325 T2060 T2061 det the,allele
R1326 T2061 T2059 pobj allele,from
R1327 T2062 T2061 compound XpdTTD,allele
R1328 T2063 T2057 auxpass was,increased
R1329 T2064 T2057 advcl relative,increased
R1330 T2065 T2064 prep to,relative
R1331 T2066 T2065 pobj wt,to
R1332 T2067 T2057 prep by,increased
R1333 T2068 T2069 punct ~,5-fold
R1334 T2069 T2067 pobj 5-fold,by
R1335 T2070 T2071 punct (,1E
R1336 T2071 T2057 parataxis 1E,increased
R1337 T2072 T2071 compound Figure,1E
R1338 T2073 T2071 punct ),1E
R1339 T2074 T2041 punct .,reduced
R1340 T2076 T2077 prep Because,were
R1341 T2078 T2076 pcomp of,Because
R1342 T2079 T2080 det a,lack
R1343 T2080 T2076 pobj lack,Because
R1344 T2081 T2080 prep of,lack
R1345 T2082 T2083 amod available,antibodies
R1346 T2083 T2081 pobj antibodies,of
R1347 T2084 T2083 cc and,antibodies
R1348 T2085 T2086 det the,inability
R1349 T2086 T2083 conj inability,antibodies
R1350 T2087 T2088 aux to,distinguish
R1351 T2088 T2086 acl distinguish,inability
R1352 T2089 T2088 prep amongst,distinguish
R1353 T2090 T2091 amod various,forms
R1354 T2091 T2089 pobj forms,amongst
R1355 T2092 T2091 amod mutant,forms
R1356 T2093 T2091 prep of,forms
R1357 T2094 T2093 pobj XPD,of
R1358 T2095 T2091 acl differing,forms
R1359 T2096 T2095 advmod only,differing
R1360 T2097 T2095 prep by,differing
R1361 T2098 T2099 amod single,substitutions
R1362 T2099 T2097 pobj substitutions,by
R1363 T2100 T2101 compound amino,acid
R1364 T2101 T2099 compound acid,substitutions
R1365 T2102 T2077 punct ", ",were
R1366 T2103 T2077 nsubj we,were
R1367 T2104 T2077 acomp unable,were
R1368 T2105 T2106 aux to,ascertain
R1369 T2106 T2104 xcomp ascertain,unable
R1370 T2107 T2108 det the,amount
R1371 T2108 T2106 dobj amount,ascertain
R1372 T2109 T2108 amod relative,amount
R1373 T2110 T2108 prep of,amount
R1374 T2111 T2112 compound XPD,protein
R1375 T2112 T2110 pobj protein,of
R1376 T2113 T2112 prep from,protein
R1377 T2114 T2115 det the,alleles
R1378 T2115 T2113 pobj alleles,from
R1379 T2116 T2115 amod different,alleles
R1380 T2117 T2077 punct .,were
R1381 T2119 T2120 prep Despite,ameliorated
R1382 T2121 T2122 amod reduced,levels
R1383 T2122 T2119 pobj levels,Despite
R1384 T2123 T2122 prep of,levels
R1385 T2124 T2125 compound mRNA,expression
R1386 T2125 T2123 pobj expression,of
R1387 T2126 T2120 punct ", ",ameliorated
R1388 T2127 T2128 det the,allele
R1389 T2128 T2120 nsubj allele,ameliorated
R1390 T2129 T2128 amod homozygous,allele
R1391 T2130 T2128 amod lethal,allele
R1392 T2131 T2128 compound Xpd†XPCS,allele
R1393 T2132 T2133 amod multiple,symptoms
R1394 T2133 T2120 dobj symptoms,ameliorated
R1395 T2134 T2135 npadvmod XpdTTD,associated
R1396 T2135 T2133 amod associated,symptoms
R1397 T2136 T2135 punct -,associated
R1398 T2137 T2133 compound disease,symptoms
R1399 T2138 T2120 prep in,ameliorated
R1400 T2139 T2140 amod compound,animals
R1401 T2140 T2138 pobj animals,in
R1402 T2141 T2140 amod heterozygous,animals
R1403 T2142 T2143 compound XpdTTD,†XPCS
R1404 T2143 T2140 compound †XPCS,animals
R1405 T2144 T2143 punct /,†XPCS
R1406 T2145 T2120 prep including,ameliorated
R1407 T2146 T2147 det the,hair
R1408 T2147 T2145 pobj hair,including
R1409 T2148 T2147 nmod hallmark,hair
R1410 T2149 T2147 amod brittle,hair
R1411 T2150 T2147 cc and,hair
R1412 T2151 T2152 amod cutaneous,features
R1413 T2152 T2147 conj features,hair
R1414 T2153 T2154 advmod fully,penetrant
R1415 T2154 T2147 amod penetrant,hair
R1416 T2155 T2154 prep in,penetrant
R1417 T2156 T2157 advmod homo,hemizygous
R1418 T2157 T2160 amod hemizygous,mice
R1419 T2158 T2157 punct -,hemizygous
R1420 T2159 T2157 cc and,hemizygous
R1421 T2160 T2155 pobj mice,in
R1422 T2161 T2160 compound TTD,mice
R1423 T2162 T2163 punct (,2A
R1424 T2163 T2120 parataxis 2A,ameliorated
R1425 T2164 T2163 compound Figure,2A
R1426 T2165 T2166 punct –,2C
R1427 T2166 T2163 prep 2C,2A
R1428 T2167 T2163 punct ),2A
R1429 T2168 T2120 punct .,ameliorated
R1430 T2170 T2171 prep In,displayed
R1431 T2172 T2173 amod marked,contrast
R1432 T2173 T2170 pobj contrast,In
R1433 T2174 T2173 prep to,contrast
R1434 T2175 T2176 nmod XpdTTD,TTD
R1435 T2176 T2178 nmod TTD,mice
R1436 T2177 T2176 punct /,TTD
R1437 T2178 T2174 pobj mice,to
R1438 T2179 T2176 punct (,TTD
R1439 T2180 T2176 cc and,TTD
R1440 T2181 T2182 compound XpdTTD,KO
R1441 T2182 T2176 conj KO,TTD
R1442 T2183 T2182 punct /,KO
R1443 T2184 T2178 punct ),mice
R1444 T2185 T2178 punct ", ",mice
R1445 T2186 T2187 dep which,display
R1446 T2187 T2178 relcl display,mice
R1447 T2188 T2189 amod complete,loss
R1448 T2189 T2187 dobj loss,display
R1449 T2190 T2189 compound hair,loss
R1450 T2191 T2189 prep in,loss
R1451 T2192 T2193 det the,cycle
R1452 T2193 T2191 pobj cycle,in
R1453 T2194 T2193 amod first,cycle
R1454 T2195 T2193 compound hair,cycle
R1455 T2196 T2189 cc and,loss
R1456 T2197 T2198 amod partial,loss
R1457 T2198 T2189 conj loss,loss
R1458 T2199 T2198 compound hair,loss
R1459 T2200 T2198 prep in,loss
R1460 T2201 T2202 amod subsequent,cycles
R1461 T2202 T2200 pobj cycles,in
R1462 T2203 T2187 prep throughout,display
R1463 T2204 T2205 poss their,lives
R1464 T2205 T2203 pobj lives,throughout
R1465 T2206 T2207 punct [,21
R1466 T2207 T2187 parataxis 21,display
R1467 T2208 T2207 punct ],21
R1468 T2209 T2171 punct ", ",displayed
R1469 T2210 T2211 nmod compound,mice
R1470 T2211 T2171 nsubj mice,displayed
R1471 T2212 T2211 amod heterozygous,mice
R1472 T2213 T2211 compound XpdTTD/†XPCS,mice
R1473 T2214 T2215 det some,loss
R1474 T2215 T2171 dobj loss,displayed
R1475 T2216 T2215 compound hair,loss
R1476 T2217 T2218 advmod only,during
R1477 T2218 T2171 prep during,displayed
R1478 T2219 T2220 det the,cycle
R1479 T2220 T2218 pobj cycle,during
R1480 T2221 T2220 amod first,cycle
R1481 T2222 T2220 compound hair,cycle
R1482 T2223 T2218 cc and,during
R1483 T2224 T2225 advmod only,locally
R1484 T2225 T2226 advmod locally,at
R1485 T2226 T2218 conj at,during
R1486 T2227 T2228 det the,back
R1487 T2228 T2226 pobj back,at
R1488 T2229 T2230 punct (,2A
R1489 T2230 T2171 parataxis 2A,displayed
R1490 T2231 T2230 compound Figure,2A
R1491 T2232 T2230 punct ),2A
R1492 T2233 T2171 punct .,displayed
R1493 T2235 T2236 compound Scanning,microscope
R1494 T2236 T2238 compound microscope,analysis
R1495 T2237 T2236 compound electron,microscope
R1496 T2238 T2239 nsubj analysis,revealed
R1497 T2240 T2238 prep of,analysis
R1498 T2241 T2242 compound XpdTTD,†XPCS
R1499 T2242 T2244 compound †XPCS,hair
R1500 T2243 T2242 punct /,†XPCS
R1501 T2244 T2240 pobj hair,of
R1502 T2245 T2246 det an,appearance
R1503 T2246 T2239 dobj appearance,revealed
R1504 T2247 T2248 advmod almost,normal
R1505 T2248 T2246 amod normal,appearance
R1506 T2249 T2246 punct ", ",appearance
R1507 T2250 T2246 prep with,appearance
R1508 T2251 T2252 npadvmod TTD,like
R1509 T2252 T2254 amod like,features
R1510 T2253 T2252 punct -,like
R1511 T2254 T2250 pobj features,with
R1512 T2255 T2256 amod such,as
R1513 T2256 T2254 prep as,features
R1514 T2257 T2258 amod broken,hairs
R1515 T2258 T2256 pobj hairs,as
R1516 T2259 T2254 acl found,features
R1517 T2260 T2261 advmod only,at
R1518 T2261 T2259 prep at,found
R1519 T2262 T2263 advmod very,low
R1520 T2263 T2264 amod low,frequency
R1521 T2264 T2261 pobj frequency,at
R1522 T2265 T2266 punct (,data
R1523 T2266 T2239 parataxis data,revealed
R1524 T2267 T2266 amod unpublished,data
R1525 T2268 T2266 punct ),data
R1526 T2269 T2239 punct .,revealed
R1527 T2271 T2272 compound Amino,acid
R1528 T2272 T2273 compound acid,analysis
R1529 T2273 T2274 nsubj analysis,confirmed
R1530 T2275 T2276 mark that,were
R1531 T2276 T2274 ccomp were,confirmed
R1532 T2277 T2278 compound cysteine,levels
R1533 T2278 T2276 nsubj levels,were
R1534 T2279 T2278 prep in,levels
R1535 T2280 T2281 det the,hair
R1536 T2281 T2279 pobj hair,in
R1537 T2282 T2281 prep of,hair
R1538 T2283 T2284 det the,mice
R1539 T2284 T2282 pobj mice,of
R1540 T2285 T2286 compound XpdTTD,†XPCS
R1541 T2286 T2284 compound †XPCS,mice
R1542 T2287 T2286 punct /,†XPCS
R1543 T2288 T2289 advmod significantly,higher
R1544 T2289 T2276 acomp higher,were
R1545 T2290 T2289 prep than,higher
R1546 T2291 T2290 prep in,than
R1547 T2292 T2293 compound XpdTTD,TTD
R1548 T2293 T2295 compound TTD,animals
R1549 T2294 T2293 punct /,TTD
R1550 T2295 T2291 pobj animals,in
R1551 T2296 T2276 punct ", ",were
R1552 T2297 T2276 cc but,were
R1553 T2298 T2276 conj remained,were
R1554 T2299 T2298 prep below,remained
R1555 T2300 T2301 det the,level
R1557 T2302 T2301 compound wt,level
R1625 T2374 T2372 cc and,layer
R1626 T2375 T2376 amod sebacious,gland
R1627 T2376 T2377 compound gland,hyperplasia
R1628 T2377 T2372 conj hyperplasia,layer
R1629 T2378 T2379 punct (,causing
R1630 T2379 T2377 parataxis causing,hyperplasia
R1631 T2380 T2381 amod greasy,appearance
R1632 T2381 T2379 dobj appearance,causing
R1633 T2382 T2381 prep of,appearance
R1634 T2383 T2384 det the,hair
R1635 T2384 T2382 pobj hair,of
R1636 T2385 T2379 punct ),causing
R1637 T2386 T2342 punct ", ",were
R1638 T2387 T2342 acomp absent,were
R1639 T2388 T2342 prep in,were
R1640 T2389 T2390 det the,skin
R1641 T2390 T2388 pobj skin,in
R1642 T2391 T2390 prep of,skin
R1643 T2392 T2393 compound XpdTTD,†XPCS
R1644 T2393 T2395 compound †XPCS,mice
R1645 T2394 T2393 punct /,†XPCS
R1646 T2395 T2391 pobj mice,of
R1647 T2396 T2342 punct ", ",were
R1648 T2397 T2398 mark as,established
R1649 T2398 T2342 advcl established,were
R1650 T2399 T2398 prep by,established
R1651 T2400 T2401 amod blind,examination
R1652 T2401 T2399 pobj examination,by
R1653 T2402 T2401 amod microscopic,examination
R1654 T2403 T2401 prep of,examination
R1655 T2404 T2405 compound skin,sections
R1656 T2405 T2403 pobj sections,of
R1657 T2406 T2407 punct (,2B
R1658 T2407 T2342 parataxis 2B,were
R1659 T2408 T2407 compound Figure,2B
R1660 T2409 T2407 punct ),2B
R1661 T2410 T2342 punct .,were
R1662 T2412 T2413 advmod Furthermore,rescued
R1663 T2414 T2413 punct ", ",rescued
R1664 T2415 T2413 nsubjpass anaemia,rescued
R1665 T2416 T2415 cc and,anaemia
R1666 T2417 T2418 amod developmental,delay
R1667 T2418 T2415 conj delay,anaemia
R1668 T2419 T2415 amod present,anaemia
R1669 T2420 T2419 prep in,present
R1670 T2421 T2420 pobj patients,in
R1671 T2422 T2421 prep with,patients
R1672 T2423 T2422 pobj TTD,with
R1673 T2424 T2425 punct [,24
R1674 T2425 T2421 parataxis 24,patients
R1675 T2426 T2425 punct ],24
R1676 T2427 T2420 cc and,in
R1677 T2428 T2420 conj in,in
R1678 T2429 T2430 compound XpdTTD,TTD
R1679 T2430 T2432 compound TTD,mice
R1680 T2431 T2430 punct /,TTD
R1681 T2432 T2428 pobj mice,in
R1682 T2433 T2434 punct [,15
R1683 T2434 T2432 parataxis 15,mice
R1684 T2435 T2434 punct ],15
R1685 T2436 T2413 auxpass were,rescued
R1686 T2437 T2413 advmod both,rescued
R1687 T2438 T2413 advmod partially,rescued
R1688 T2439 T2413 prep in,rescued
R1689 T2440 T2441 amod compound,mice
R1690 T2441 T2439 pobj mice,in
R1691 T2442 T2441 amod heterozygous,mice
R1692 T2443 T2444 compound XpdTTD,†XPCS
R1693 T2444 T2441 compound †XPCS,mice
R1694 T2445 T2444 punct /,†XPCS
R1695 T2446 T2447 punct (,2D
R1696 T2447 T2413 parataxis 2D,rescued
R1697 T2448 T2447 compound Figure,2D
R1698 T2449 T2447 cc and,2D
R1699 T2450 T2447 conj 2E,2D
R1700 T2451 T2447 punct ),2D
R1701 T2452 T2413 punct .,rescued
R1702 T2573 T2572 prep of,Rescue
R1703 T2574 T2575 amod "Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles Compound Heterozygosity at theXpd Locus Abstract Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background. We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models. Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria. We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii) differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals. Our data suggest a re-evaluation of the contribution of “null” alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals. Effects of mutations in Xpd were investigated in mice. Compound heterozygotes of otherwise homozygous lethal alleles demonstrated interallelic complementation and partial phenotypic rescue of XPD-related disease symptoms. Introduction Interallelic complementation is defined as the ability of two differentially mutated alleles to function better together than either can on its own. Despite its near universality in lower organisms [1], its potential to contribute to clinical heterogeneity in human disease is seldom considered. Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5]. Compound heterozygotes are individuals carrying two different mutant alleles of the same gene. In the absence of a dominant (wild-type [wt]) allele, genetic interactions between recessive alleles (referred to here as “biallelic” effects) could result in different phenotypic outcomes including interallelic complementation. Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background. XPD encodes one of the two helicase components of basal transcription/DNA repair factor IIH (TFIIH), a ten-subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7]. Alterations in XPD resulting in defective TFIIH function are associated with UV-sensitive, multisystem disorders including xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD) [8–10]. XP is marked by sun-induced pigmentation anomalies and a greater than 1,000-fold elevation in skin cancer risk. Severe cases can also present with growth retardation and primary neurodegeneration [11]. CS and TTD, on the other hand, are segmental progeroid disorders characterised by progressive post-natal growth failure and primary demyelination resulting in severe neurodysfunction, but without a clear cancer predisposition [12–15]. Patients with TTD additionally display hallmark sulphur-deficient brittle hair and nails and scaling skin [13], resulting from a basal transcription defect in specific cell types [16,17]. A related disorder with the cancer predisposition of XP combined with the neurodevelopmental complications of CS (XPCS), although rare, has also been described [18]. Many XPD mutations are associated with an exclusive disease phenotype (e.g., XPDR722W with TTD and XPDR683W with XP) and are thus viewed as causative of the corresponding syndromes. Alleles not associated exclusively with one disorder are considered “likely null” alleles [19,20]. Some of these alleles fail to support viability in a haploid Schizosaccharomyces pombe yeast strain with a null mutation in the XPD homologue rad15 and are thus considered devoid of significant biological activity [19]. This classification of alleles as either causative or null currently defines what we refer to as a “monoallelic” paradigm of XPD disease. However, the identification in recent years of XP complementation group D patients with atypical disease presentation, including symptoms of both XP and TTD [8], casts doubt on the ability of such a monoallelic paradigm to explain clinical heterogeneity in compound heterozygotes. Previously, we generated a TTD mouse model (XPDR722W) that phenocopies the human syndrome [15,21]. Here we report the generation of additional mutant Xpd alleles that fail to support viability on their own but nevertheless ameliorate TTD-associated premature segmental ageing, cutaneous features, cellular DNA repair capacity, and UV survival when present in a compound heterozygote state. Results Generation of Xpd Compound Heterozygotes We generated an Xpd knock-in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A–1C). mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E). Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state. However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1). The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS). Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself. Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22]. Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data). Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23]. Figure 1 Targeting of the Mouse Xpd Gene (A) Schematic representation of the genomic structure and partial restriction map of the wt and targeted mouse Xpd loci. For the wt Xpd allele, shaded boxes represent coding regions of exons 12 and 19–23; the 3′UTR is represented by an open box. TGA indicates the translational stop codon; PolyA indicates the polyadenylation signal. For the XpdTTD targeted allele, the 194–base pair (bp) human XPD cDNA fragment fused to exon 22 is indicated as a striped box including the TTD (R722W) mutation indicated by a vertical arrow. Chicken β-globin exons 2 and 3 including the 3′UTR are indicated as black boxes with corresponding Roman numerals followed by the β-globin polyadenylation signal (PolyA*). For the Xpd†XP and Xpd†XPCS targeted alleles, vertical arrows indicate XPCS (G602D-encoding) and XP (R683W-encoding) mutations in exons 19 and 22, respectively. The unique 3′ probe located outside the targeting construct is marked by a thick black line. Restriction sites: B, BamHI; C, ClaI; E, EcoRI; H, HindIII; Hp, HpaI; Sf, SfiI. (B) Southern blot analysis of EcoRI-digested genomic DNA from wt, Xpd†XPCS/wt, and Xpd†XP/wt recombinant embryonic stem cell clones hybridised with the 3′ probe depicted in (A). The wt allele yields a 6.5-kilobase (kb) fragment, whereas both targeted Xpd†XP and Xpd†XPCS alleles yield a 5.1-kb fragment. (C) Genotyping of wt and targeted alleles by PCR using primers F2, R1, and mR as indicated in (A) yields fragments of 399 bp and 468 bp, respectively. (D) RT-PCR detection of mRNA expression originating from the targeted †XP and †XPCS alleles in embryonic stem cell clones using primers F1 (hybridising outside the targeting construct) and mR as indicated in (A) results in a 1,416-bp fragment. (E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD/TTD, heterozygous Xpd†XPCS/wt and XpdTTD/wt, and compound heterozygous Xpd†XPCS/TTD mice as indicated. Hybridisation with a 1.4-kb mouse Xpd cDNA probe detects mRNAs of 4, 3.3, and 2.7 kb from wt, Xpd†XPCS, and XpdTTD alleles, respectively. An ethidium bromide (EtBr)–stained gel showing the amount of total RNA loaded is shown below. Table 1 Frequency of Xpd†XP/†XP, Xpd†XPCS/†XPCS, and Compound Heterozygous Xpd†XP/†XPCS Embryos and Offspring “Null” Allele Can Alleviate Developmental Delay, Skin, and Hair Features of TTD To test the potential of a homozygous lethal “null” allele to nevertheless contribute to organismal phenotype, we combined an Xpd†XPCS allele with a viable XpdTTD allele by crossing the corresponding heterozygous animals. Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies. Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E). Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles. Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C). In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A). Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data). Amino acid analysis confirmed that cysteine levels in the hair of the XpdTTD/†XPCS mice were significantly higher than in XpdTTD/TTD animals, but remained below the wt level (Figure 2C). TTD hemizygotes (XpdTTD/KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD/TTD mice [21]. Figure 2 Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous XpdTTD/†XPCS Mice (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice. Insets: images of first-round hair loss. (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice. Magnification 400×. (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice. The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice. Error bars indicate standard error of the mean (SEM). (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice. The p-values indicate the significance of the difference relative to wt. Error bars indicate SEM. (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM. Other prominent TTD features in the epidermis, including acanthosis (thickening of the layer of the nucleated cells), hyperkeratosis (prominent thickening of the cornified layer), and pronounced granular layer and sebacious gland hyperplasia (causing greasy appearance of the hair), were absent in the skin of XpdTTD/†XPCS mice, as established by blind microscopic examination of skin sections (Figure 2B). Furthermore, anaemia and developmental delay present in patients with TTD [24] and in XpdTTD/TTD mice [15] were both partially rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 2D and 2E). Rescue of Progeroid",Features
R1704 T2575 T2573 pobj Features,of
R1705 T2576 T2572 prep in,Rescue
R1706 T2577 T2578 compound TTD,Mice
R1707 T2578 T2576 pobj Mice,in
R1708 T2579 T2572 prep by,Rescue
R1709 T2580 T2581 amod Homozygous,Alleles
R1710 T2581 T2579 pobj Alleles,by
R1711 T2582 T2581 amod Lethal,Alleles
R1712 T2583 T2581 compound Xpd,Alleles
R1713 T2585 T2586 mark Because,share
R1714 T2586 T2605 advcl share,addressed
R1715 T2587 T2586 nsubj patients,share
R1716 T2588 T2587 prep with,patients
R1717 T2589 T2588 pobj TTD,with
R1718 T2590 T2589 punct ", ",TTD
R1719 T2591 T2589 conj XPCS,TTD
R1720 T2592 T2591 punct ", ",XPCS
R1721 T2593 T2591 cc and,XPCS
R1722 T2594 T2591 conj CS,XPCS
R1723 T2595 T2589 punct (,TTD
R1724 T2596 T2589 cc but,TTD
R1725 T2597 T2596 neg not,but
R1726 T2598 T2589 conj XP,TTD
R1727 T2599 T2587 punct ),patients
R1728 T2600 T2587 cc and,patients
R1729 T2601 T2602 det the,models
R1730 T2602 T2587 conj models,patients
R1731 T2603 T2602 amod corresponding,models
R1732 T2604 T2602 compound mouse,models
R1733 T2606 T2607 amod similar,symptoms
R1734 T2607 T2586 dobj symptoms,share
R1735 T2608 T2607 amod accelerated,symptoms
R1736 T2609 T2607 compound progeroid,symptoms
R1737 T2610 T2611 punct [,23
R1738 T2611 T2586 parataxis 23,share
R1739 T2612 T2611 nummod 12,23
R1740 T2613 T2611 punct ",",23
R1741 T2614 T2611 nummod 13,23
R1742 T2615 T2611 punct ",",23
R1743 T2616 T2611 nummod 15,23
R1744 T2617 T2611 punct ",",23
R1745 T2618 T2611 punct ],23
R1746 T2619 T2605 punct ", ",addressed
R1747 T2620 T2605 nsubj we,addressed
R1748 T2621 T2605 advmod next,addressed
R1749 T2622 T2623 amod ageing,related
R1750 T2623 T2625 amod related,parameters
R1751 T2624 T2623 punct -,related
R1752 T2625 T2605 dobj parameters,addressed
R1753 T2626 T2625 prep in,parameters
R1754 T2627 T2628 amod compound,mice
R1755 T2628 T2626 pobj mice,in
R1756 T2629 T2628 amod heterozygous,mice
R1757 T2630 T2631 punct (,Figure
R1758 T2631 T2605 parataxis Figure,addressed
R1759 T2632 T2631 nummod 3,Figure
R1760 T2633 T2631 punct ),Figure
R1761 T2634 T2605 punct .,addressed
R1762 T2636 T2637 mark Whereas,show
R1763 T2637 T2642 advcl show,were
R1764 T2638 T2639 compound XpdTTD,TTD
R1765 T2639 T2641 compound TTD,animals
R1766 T2640 T2639 punct /,TTD
R1767 T2641 T2637 nsubj animals,show
R1768 T2643 T2644 amod reduced,density
R1769 T2644 T2637 dobj density,show
R1770 T2645 T2646 compound bone,mineral
R1771 T2646 T2644 compound mineral,density
R1772 T2647 T2637 prep as,show
R1773 T2648 T2649 det an,indication
R1774 T2649 T2647 pobj indication,as
R1775 T2650 T2649 prep of,indication
R1776 T2651 T2652 det the,onset
R1777 T2652 T2650 pobj onset,of
R1778 T2653 T2652 amod early,onset
R1779 T2654 T2652 prep of,onset
R1780 T2655 T2654 pobj osteoporosis,of
R1781 T2656 T2652 prep before,onset
R1782 T2657 T2658 punct ~,14
R1783 T2658 T2659 nummod 14,mo
R1784 T2659 T2656 pobj mo,before
R1785 T2660 T2659 prep of,mo
R1786 T2661 T2660 pobj age,of
R1787 T2662 T2663 punct [,15
R1788 T2663 T2637 parataxis 15,show
R1789 T2664 T2663 punct ],15
R1790 T2665 T2642 punct ", ",were
R1791 T2666 T2667 compound tail,vertebrae
R1792 T2667 T2642 nsubj vertebrae,were
R1793 T2668 T2667 prep from,vertebrae
R1794 T2669 T2670 nmod compound,mice
R1795 T2670 T2668 pobj mice,from
R1796 T2671 T2670 amod heterozygous,mice
R1797 T2672 T2673 compound XpdTTD,†XPCS
R1798 T2673 T2670 compound †XPCS,mice
R1799 T2674 T2673 punct /,†XPCS
R1800 T2675 T2642 acomp comparable,were
R1801 T2676 T2675 prep to,comparable
R1802 T2677 T2676 pobj wt,to
R1803 T2678 T2679 advmod even,at
R1804 T2679 T2642 prep at,were
R1805 T2680 T2681 nummod 20,mo
R1806 T2681 T2679 pobj mo,at
R1807 T2682 T2681 prep of,mo
R1808 T2683 T2682 pobj age,of
R1809 T2684 T2685 punct (,3B
R1810 T2685 T2642 parataxis 3B,were
R1811 T2686 T2685 compound Figure,3B
R1812 T2687 T2685 cc and,3B
R1813 T2688 T2685 conj 3C,3B
R1814 T2689 T2685 punct ),3B
R1815 T2690 T2642 punct .,were
R1816 T2692 T2693 advmod Furthermore,3B
R1817 T2694 T2693 punct ", ",3B
R1818 T2695 T2696 mark whereas,developed
R1819 T2696 T2693 advcl developed,3B
R1820 T2697 T2698 compound XpdTTD,TTD
R1821 T2698 T2700 compound TTD,mice
R1822 T2699 T2698 punct /,TTD
R1823 T2700 T2696 nsubj mice,developed
R1824 T2701 T2696 dobj kyphosis,developed
R1825 T2702 T2696 advmod earlier,developed
R1826 T2703 T2702 prep than,earlier
R1827 T2704 T2705 compound wt,animals
R1828 T2705 T2703 pobj animals,than
R1829 T2706 T2707 punct (,onset
R1830 T2707 T2702 parataxis onset,earlier
R1831 T2708 T2709 punct ~,3
R1832 T2709 T2710 nummod 3,mo
R1833 T2710 T2707 npadvmod mo,onset
R1834 T2711 T2710 cc versus,mo
R1835 T2712 T2713 quantmod 12,20
R1836 T2713 T2715 nummod 20,mo
R1837 T2714 T2713 punct –,20
R1838 T2715 T2710 conj mo,mo
R1839 T2716 T2707 punct ),onset
R1840 T2717 T2693 punct ", ",3B
R1841 T2718 T2719 amod compound,mice
R1842 T2719 T2693 nsubj mice,3B
R1843 T2720 T2719 amod heterozygous,mice
R1844 T2721 T2722 compound XpdTTD,†XPCS
R1845 T2722 T2719 compound †XPCS,mice
R1846 T2723 T2722 punct /,†XPCS
R1847 T2724 T2693 aux did,3B
R1848 T2725 T2693 neg not,3B
R1849 T2726 T2693 punct (,3B
R1850 T2727 T2693 compound Figure,3B
R1851 T2728 T2693 punct ),3B
R1852 T2729 T2693 punct .,3B
R1853 T2731 T2732 amod Overall,appearance
R1854 T2732 T2733 nsubj appearance,revealed
R1855 T2734 T2732 cc and,appearance
R1856 T2735 T2736 compound body,weight
R1857 T2736 T2737 compound weight,curves
R1858 T2737 T2732 conj curves,appearance
R1859 T2738 T2739 mark that,rescued
R1891 T2772 T2771 punct ", ",extended
R1892 T2773 T2774 det the,span
R1893 T2774 T2771 nsubjpass span,extended
R1894 T2775 T2774 compound life,span
R1895 T2776 T2774 prep of,span
R1896 T2777 T2778 amod compound,heterozygotes
R1897 T2778 T2776 pobj heterozygotes,of
R1898 T2779 T2771 auxpass was,extended
R1899 T2780 T2771 advcl relative,extended
R1900 T2781 T2780 prep to,relative
R1901 T2782 T2783 compound XpdTTD,TTD
R1902 T2783 T2785 compound TTD,mice
R1903 T2784 T2783 punct /,TTD
R1904 T2785 T2781 pobj mice,to
R1905 T2786 T2787 punct (,Table
R1906 T2787 T2771 parataxis Table,extended
R1907 T2788 T2787 nummod 2,Table
R1908 T2789 T2787 punct ),Table
R1909 T2790 T2771 punct .,extended
R1923 T2806 T2807 aux to,ameliorate
R1924 T2807 T2805 acl ameliorate,ability
R1925 T2808 T2807 dobj symptoms,ameliorate
R1926 T2809 T2808 acl associated,symptoms
R1927 T2810 T2809 prep with,associated
R1928 T2811 T2812 det the,allele
R1929 T2812 T2810 pobj allele,with
R1930 T2813 T2812 compound XpdTTD,allele
R1931 T2814 T2794 punct ", ",generated
R1932 T2815 T2794 nsubj we,generated
R1933 T2816 T2817 nmod compound,mice
R1934 T2817 T2794 dobj mice,generated
R1935 T2818 T2817 amod heterozygous,mice
R1936 T2819 T2820 compound XpdTTD,†XP
R1937 T2820 T2817 compound †XP,mice
R1938 T2821 T2820 punct /,†XP
R1939 T2822 T2794 prep by,generated
R1940 T2823 T2822 pcomp crossing,by
R1941 T2824 T2825 det the,animals
R1942 T2825 T2823 dobj animals,crossing
R1943 T2826 T2825 amod corresponding,animals
R1944 T2827 T2825 amod heterozygous,animals
R1945 T2828 T2794 punct .,generated
R1946 T2830 T2831 advcl Similar,rescued
R1947 T2832 T2830 prep to,Similar
R1948 T2833 T2834 det the,allele
R1949 T2834 T2832 pobj allele,to
R1950 T2835 T2834 compound Xpd †XPCS,allele
R1951 T2836 T2831 punct ", ",rescued
R1952 T2837 T2838 det the,allele
R1953 T2838 T2831 nsubj allele,rescued
R1954 T2839 T2838 amod homozygous,allele
R1955 T2840 T2838 amod lethal,allele
R1956 T2841 T2838 compound Xpd †XP,allele
R1957 T2842 T2843 amod cutaneous,symptoms
R1958 T2843 T2831 dobj symptoms,rescued
R1959 T2844 T2843 prep including,symptoms
R1960 T2845 T2846 compound hair,loss
R1961 T2846 T2844 pobj loss,including
R1962 T2847 T2848 punct (,data
R1963 T2848 T2846 parataxis data,loss
R1964 T2849 T2848 prep except,data
R1965 T2850 T2849 pcomp locally,except
R1966 T2851 T2850 prep during,locally
R1967 T2852 T2853 det the,round
R1968 T2853 T2851 pobj round,during
R1969 T2854 T2853 amod first,round
R1970 T2855 T2848 punct ;,data
R1971 T2856 T2848 amod unpublished,data
R1972 T2857 T2848 punct ),data
R1973 T2858 T2846 punct ", ",loss
R1974 T2859 T2860 amod reduced,content
R1975 T2860 T2846 conj content,loss
R1976 T2861 T2860 compound cysteine,content
R1977 T2862 T2863 punct (,index
R1978 T2863 T2860 parataxis index,content
R1979 T2864 T2863 compound cysteine,index
R1980 T2865 T2863 npadvmod 9.3,index
R1981 T2866 T2865 punct ±,9.3
R1982 T2867 T2868 nummod 0.9,deviation
R1983 T2868 T2865 appos deviation,9.3
R1984 T2869 T2868 amod standard,deviation
R1985 T2870 T2871 punct [,%
R1986 T2871 T2865 parataxis %,9.3
R1987 T2872 T2871 nummod 87,%
R1988 T2873 T2871 prep of,%
R1989 T2874 T2873 pobj wt,of
R1990 T2875 T2871 punct ],%
R1991 T2876 T2863 punct ", ",index
R1992 T2877 T2878 nsubj p,TTD
R1993 T2878 T2863 ccomp TTD,index
R1994 T2879 T2878 punct =,TTD
R1995 T2880 T2878 nummod 0.01,TTD
R1996 T2881 T2878 cc versus,TTD
R1997 T2882 T2863 punct ),index
R1998 T2883 T2860 punct ", ",content
R1999 T2884 T2885 npadvmod ageing,associated
R2000 T2885 T2887 amod associated,cachexia
R2001 T2886 T2885 punct -,associated
R2002 T2887 T2860 conj cachexia,content
R2003 T2888 T2887 amod premature,cachexia
R2004 T2889 T2890 punct (,were
R2005 T2890 T2887 parataxis were,cachexia
R2006 T2891 T2890 nsubj males,were
R2007 T2892 T2891 cc and,males
R2008 T2893 T2891 conj females,males
R2009 T2894 T2895 nummod 36.1,6.4
R2010 T2895 T2897 nummod 6.4,g
R2011 T2896 T2895 punct ±,6.4
R2012 T2897 T2890 attr g,were
R2013 T2898 T2899 punct [,%
R2014 T2899 T2897 parataxis %,g
R2015 T2900 T2899 nummod 93,%
R2016 T2901 T2899 prep of,%
R2017 T2902 T2901 pobj wt,of
R2018 T2903 T2899 punct ],%
R2019 T2904 T2897 cc and,g
R2020 T2905 T2906 nummod 39.2,3.2
R2021 T2906 T2908 nummod 3.2,g
R2022 T2907 T2906 punct ±,3.2
R2023 T2908 T2897 conj g,g
R2024 T2909 T2910 punct [,%
R2025 T2910 T2908 parataxis %,g
R2026 T2911 T2910 nummod 116,%
R2027 T2912 T2910 prep of,%
R2028 T2913 T2912 pobj wt,of
R2029 T2914 T2910 punct ],%
R2030 T2915 T2890 punct ", ",were
R2031 T2916 T2890 advmod respectively,were
R2032 T2917 T2890 punct ),were
R2033 T2918 T2887 punct ", ",cachexia
R2034 T2919 T2887 cc and,cachexia
R2035 T2920 T2921 amod reduced,span
R2036 T2921 T2887 conj span,cachexia
R2037 T2922 T2921 compound life,span
R2038 T2923 T2924 punct (,Table
R2039 T2924 T2831 parataxis Table,rescued
R2040 T2925 T2924 nummod 2,Table
R2041 T2926 T2924 punct ),Table
R2042 T2927 T2831 punct .,rescued
R2043 T2929 T2930 advcl Taken,indicate
R2044 T2931 T2929 advmod together,Taken
R2045 T2932 T2930 punct ", ",indicate
R2046 T2933 T2934 det these,data
R2047 T2934 T2930 nsubj data,indicate
R2048 T2935 T2936 mark that,were
R2049 T2936 T2930 ccomp were,indicate
R2050 T2937 T2938 nummod two,alleles
R2051 T2938 T2936 nsubj alleles,were
R2052 T2939 T2938 amod independent,alleles
R2053 T2940 T2938 punct ", ",alleles
R2054 T2941 T2942 dep which,are
R2055 T2942 T2938 relcl are,alleles
R2056 T2943 T2942 prep on,are
R2057 T2944 T2945 poss their,own
R2058 T2945 T2943 pobj own,on
R2059 T2946 T2942 acomp unable,are
R2060 T2947 T2948 aux to,support
R2061 T2948 T2946 xcomp support,unable
R2062 T2949 T2948 dobj viability,support
R2063 T2950 T2951 punct (,Table
R2064 T2951 T2948 parataxis Table,support
R2065 T2952 T2951 nummod 1,Table
R2066 T2953 T2951 punct ),Table
R2067 T2954 T2936 punct ", ",were
R2068 T2955 T2936 advmod nonetheless,were
R2069 T2956 T2936 acomp able,were
R2070 T2957 T2958 aux to,ameliorate
R2071 T2958 T2956 xcomp ameliorate,able
R2072 T2959 T2960 npadvmod TTD,associated
R2073 T2960 T2962 amod associated,phenotypes
R2074 T2961 T2960 punct -,associated
R2075 T2962 T2958 dobj phenotypes,ameliorate
R2076 T2963 T2964 advmod in,vivo
R2077 T2964 T2958 advmod vivo,ameliorate
R2078 T2965 T2966 punct (,Table
R2079 T2966 T2958 parataxis Table,ameliorate
R2080 T2967 T2966 nummod 2,Table
R2081 T2968 T2966 punct ),Table
R2082 T2969 T2930 punct .,indicate
R2083 T3312 T3313 amod Molecular,Mechanisms
R2084 T3314 T3313 prep of,Mechanisms
R2085 T3315 T3316 amod Biallelic,Effects
R2086 T3316 T3314 pobj Effects,of
R2087 T3318 T3319 nsubj We,turned
R2088 T3320 T3319 advmod next,turned
R2089 T3321 T3319 prep to,turned
R2090 T3322 T3323 npadvmod UV,based
R2091 T3323 T3325 amod based,assays
R2092 T3324 T3323 punct -,based
R2093 T3325 T3321 pobj assays,to
R2094 T3326 T3325 amod cellular,assays
R2095 T3327 T3325 prep including,assays
R2096 T3328 T3329 amod unscheduled,synthesis
R2097 T3329 T3327 pobj synthesis,including
R2098 T3330 T3329 compound DNA,synthesis
R2099 T3331 T3329 prep after,synthesis
R2100 T3332 T3333 compound UV,irradiation
R2101 T3333 T3331 pobj irradiation,after
R2102 T3334 T3335 punct (,UDS
R2103 T3335 T3329 parataxis UDS,synthesis
R2104 T3336 T3335 compound UV,UDS
R2105 T3337 T3335 punct -,UDS
R2106 T3338 T3335 punct ),UDS
R2107 T3339 T3329 punct ", ",synthesis
R2108 T3340 T3329 conj recovery,synthesis
R2109 T3341 T3340 prep of,recovery
R2110 T3342 T3343 compound RNA,synthesis
R2111 T3343 T3341 pobj synthesis,of
R2112 T3344 T3340 prep after,recovery
R2113 T3345 T3346 compound UV,irradiation
R2114 T3346 T3344 pobj irradiation,after
R2115 T3347 T3348 punct (,RRS
R2116 T3348 T3340 parataxis RRS,recovery
R2117 T3349 T3348 compound UV,RRS
R2118 T3350 T3348 punct -,RRS
R2119 T3351 T3348 punct ),RRS
R2120 T3352 T3340 punct ", ",recovery
R2121 T3353 T3340 cc and,recovery
R2122 T3354 T3355 compound UV,survival
R2123 T3355 T3340 conj survival,recovery
R2124 T3356 T3329 punct ", ",synthesis
R2125 T3357 T3358 dep which,report
R2126 T3358 T3329 relcl report,synthesis
R2127 T3359 T3358 prep on,report
R2128 T3360 T3361 det the,subpathways
R2129 T3361 T3359 pobj subpathways,on
R2130 T3362 T3361 compound NER,subpathways
R2131 T3363 T3364 punct (,NER
R2132 T3364 T3361 parataxis NER,subpathways
R2133 T3365 T3364 amod global,NER
R2134 T3366 T3364 compound genome,NER
R2135 T3367 T3364 cc and,NER
R2136 T3368 T3369 npadvmod transcription,coupled
R2137 T3369 T3371 amod coupled,NER
R2138 T3370 T3369 punct -,coupled
R2139 T3371 T3364 conj NER,NER
R2140 T3372 T3364 punct ),NER
R2141 T3373 T3361 cc and,subpathways
R2142 T3374 T3375 amod total,NER
R2143 T3375 T3361 conj NER,subpathways
R2144 T3376 T3358 punct ", ",report
R2145 T3377 T3358 advmod respectively,report
R2146 T3378 T3319 punct .,turned
R2147 T3380 T3381 prep In,improved
R2148 T3382 T3380 pobj none,In
R2149 T3383 T3382 prep of,none
R2150 T3384 T3385 det these,assays
R2151 T3385 T3383 pobj assays,of
R2152 T3386 T3381 auxpass was,improved
R2153 T3387 T3388 det the,response
R2154 T3388 T3381 nsubjpass response,improved
R2155 T3389 T3388 prep to,response
R2156 T3390 T3389 pobj UV,to
R2157 T3391 T3381 prep in,improved
R2158 T3392 T3393 compound compound,heterozygotes
R2159 T3393 T3391 pobj heterozygotes,in
R2160 T3394 T3381 advcl relative,improved
R2161 T3395 T3394 prep to,relative
R2162 T3396 T3397 compound TTD,homozygotes
R2163 T3397 T3395 pobj homozygotes,to
R2164 T3398 T3399 punct (,4A
R2165 T3399 T3381 parataxis 4A,improved
R2166 T3400 T3399 compound Figure,4A
R2167 T3401 T3402 punct –,4C
R2168 T3402 T3399 prep 4C,4A
R2169 T3403 T3399 punct ),4A
R2170 T3404 T3381 punct .,improved
R2171 T3406 T3407 advmod However,observed
R2172 T3408 T3407 punct ", ",observed
R2173 T3409 T3407 prep unlike,observed
R2174 T3410 T3411 det the,phenotypes
R2175 T3411 T3409 pobj phenotypes,unlike
R2176 T3412 T3413 advmod in,vivo
R2177 T3413 T3411 amod vivo,phenotypes
R2178 T3414 T3411 compound TTD,phenotypes
R2179 T3415 T3411 acl described,phenotypes
R2180 T3416 T3415 advmod above,described
R2181 T3417 T3411 punct ", ",phenotypes
R2182 T3418 T3419 prep in,were
R2183 T3419 T3411 relcl were,phenotypes
R2184 T3420 T3418 pobj which,in
R2185 T3421 T3422 nmod XpdTTD,TTD
R2186 T3422 T3424 nmod TTD,animals
R2187 T3423 T3422 punct /,TTD
R2188 T3424 T3419 nsubj animals,were
R2189 T3425 T3422 cc and,TTD
R2190 T3426 T3427 compound XpdTTD,KO
R2191 T3427 T3422 conj KO,TTD
R2192 T3428 T3427 punct /,KO
R2193 T3429 T3419 acomp indistinguishable,were
R2194 T3430 T3407 punct ", ",observed
R2195 T3431 T3432 compound XpdTTD,effects
R2196 T3432 T3407 nsubjpass effects,observed
R2197 T3433 T3432 compound dosage,effects
R2198 T3434 T3407 auxpass were,observed
R2199 T3435 T3407 prep in,observed
R2200 T3436 T3437 compound UV,survival
R2201 T3437 T3435 pobj survival,in
R2202 T3438 T3437 punct ", ",survival
R2203 T3439 T3440 compound UV,UDS
R2204 T3440 T3437 conj UDS,survival
R2205 T3441 T3440 punct -,UDS
R2206 T3442 T3440 punct ", ",UDS
R2207 T3443 T3440 cc and,UDS
R2208 T3444 T3445 compound UV,RRS
R2209 T3445 T3440 conj RRS,UDS
R2210 T3446 T3445 punct -,RRS
R2211 T3447 T3407 punct ", ",observed
R2212 T3448 T3407 advcl indicating,observed
R2213 T3449 T3450 mark that,correlate
R2214 T3450 T3448 ccomp correlate,indicating
R2215 T3451 T3452 amod cellular,parameters
R2216 T3452 T3450 nsubj parameters,correlate
R2217 T3453 T3454 mark as,measured
R2218 T3454 T3452 advcl measured,parameters
R2219 T3455 T3454 prep in,measured
R2220 T3456 T3455 pobj fibroblasts,in
R2221 T3457 T3454 advmod here,measured
R2222 T3458 T3450 aux do,correlate
R2223 T3459 T3450 neg not,correlate
R2224 T3460 T3450 advmod always,correlate
R2225 T3461 T3450 prep with,correlate
R2226 T3462 T3463 det the,phenotype
R2227 T3463 T3461 pobj phenotype,with
R2228 T3464 T3450 prep at,correlate
R2229 T3465 T3466 det the,level
R2230 T3466 T3464 pobj level,at
R2231 T3467 T3466 prep of,level
R2232 T3468 T3469 det the,organism
R2233 T3469 T3467 pobj organism,of
R2234 T3470 T3469 amod intact,organism
R2235 T3471 T3407 punct .,observed
R2236 T3473 T3474 nmod XpdTTD,KO
R2237 T3474 T3476 nmod KO,cells
R2238 T3475 T3474 punct /,KO
R2239 T3476 T3478 nsubjpass cells,used
R2240 T3477 T3476 amod hemizygous,cells
R2241 T3479 T3478 auxpass were,used
R2242 T3480 T3478 advmod thus,used
R2243 T3481 T3478 prep as,used
R2244 T3482 T3483 det the,baseline
R2245 T3483 T3481 pobj baseline,as
R2246 T3484 T3485 prep on,compare
R2247 T3485 T3483 relcl compare,baseline
R2248 T3486 T3484 pobj which,on
R2249 T3487 T3485 aux to,compare
R2250 T3488 T3489 det the,activity
R2251 T3489 T3485 dobj activity,compare
R2252 T3490 T3489 prep of,activity
R2253 T3491 T3492 nmod compound,cells
R2254 T3492 T3490 pobj cells,of
R2255 T3493 T3492 amod heterozygous,cells
R2256 T3494 T3478 punct .,used
R2257 T3496 T3497 advcl Relative,improved
R2258 T3498 T3496 prep to,Relative
R2259 T3499 T3500 compound XpdTTD,KO
R2260 T3500 T3502 compound KO,cells
R2261 T3501 T3500 punct /,KO
R2262 T3502 T3498 pobj cells,to
R2263 T3503 T3502 compound hemizygote,cells
R2264 T3504 T3497 punct ", ",improved
R2265 T3505 T3506 compound UV,survival
R2266 T3506 T3497 nsubjpass survival,improved
R2267 T3507 T3497 auxpass was,improved
R2268 T3508 T3497 prep by,improved
R2269 T3509 T3510 det the,allele
R2270 T3510 T3508 pobj allele,by
R2271 T3511 T3510 amod homozygous,allele
R2272 T3512 T3510 amod lethal,allele
R2273 T3513 T3510 compound Xpd†XPCS,allele
R2274 T3514 T3510 prep in,allele
R2275 T3515 T3516 nmod XpdTTD,†XPCS
R2276 T3516 T3518 nmod †XPCS,cells
R2277 T3517 T3516 punct /,†XPCS
R2278 T3518 T3514 pobj cells,in
R2279 T3519 T3518 nmod compound,cells
R2280 T3520 T3518 amod heterozygous,cells
R2281 T3521 T3508 cc and,by
R2282 T3522 T3523 prep to,by
R2283 T3523 T3508 conj by,by
R2284 T3524 T3525 det a,degree
R2285 T3525 T3522 pobj degree,to
R2286 T3526 T3525 amod lesser,degree
R2287 T3527 T3528 det the,allele
R2288 T3528 T3523 pobj allele,by
R2289 T3529 T3528 compound Xpd†XP,allele
R2290 T3530 T3531 punct (,4A
R2291 T3531 T3497 parataxis 4A,improved
R2292 T3532 T3531 compound Figure,4A
R2293 T3533 T3531 punct ),4A
R2294 T3534 T3497 punct .,improved
R2295 T3536 T3537 prep Because,were
R2296 T3538 T3536 pcomp of,Because
R2297 T3539 T3540 amod embryonic,lethality
R2298 T3540 T3536 pobj lethality,Because
R2299 T3541 T3539 cc and,embryonic
R2300 T3542 T3539 conj cellular,embryonic
R2301 T3543 T3537 punct ", ",were
R2302 T3544 T3537 nsubj we,were
R2303 T3545 T3537 acomp unable,were
R2304 T3546 T3547 aux to,test
R2305 T3547 T3545 xcomp test,unable
R2306 T3548 T3549 compound UV,survival
R2307 T3549 T3547 dobj survival,test
R2308 T3550 T3549 acl associated,survival
R2309 T3551 T3550 advmod exclusively,associated
R2310 T3552 T3550 prep with,associated
R2311 T3553 T3554 det the,alleles
R2312 T3554 T3552 pobj alleles,with
R2313 T3555 T3554 nmod Xpd†XPCS,alleles
R2314 T3556 T3555 cc or,Xpd†XPCS
R2315 T3557 T3555 conj Xpd†XP,Xpd†XPCS
R2316 T3558 T3537 punct .,were
R2317 T3560 T3561 advmod However,known
R2318 T3562 T3561 punct ", ",known
R2319 T3563 T3564 amod homozygous,XPDXP
R2320 T3564 T3565 nmod XPDXP,cells
R2321 T3565 T3561 nsubjpass cells,known
R2322 T3566 T3567 punct (,XPDR683W
R2323 T3567 T3564 parataxis XPDR683W,XPDXP
R2324 T3568 T3567 punct ),XPDR683W
R2325 T3569 T3564 cc and,XPDXP
R2326 T3570 T3571 amod hemizygous,XPDXPCS
R2327 T3571 T3564 conj XPDXPCS,XPDXP
R2328 T3572 T3573 punct (,XPDG602D
R2329 T3573 T3571 parataxis XPDG602D,XPDXPCS
R2330 T3574 T3573 punct ),XPDG602D
R2331 T3575 T3565 amod human,cells
R2332 T3576 T3561 auxpass are,known
R2333 T3577 T3578 aux to,be
R2334 T3578 T3561 xcomp be,known
R2335 T3579 T3580 advmod highly,sensitive
R2336 T3580 T3578 acomp sensitive,be
R2337 T3581 T3580 prep to,sensitive
R2338 T3582 T3581 pobj UV,to
R2339 T3583 T3584 punct [,25
R2340 T3584 T3578 parataxis 25,be
R2341 T3585 T3584 nummod 19,25
R2342 T3586 T3584 punct ",",25
R2343 T3587 T3584 punct ],25
R2344 T3588 T3561 punct ", ",known
R2345 T3589 T3590 mark as,are
R2346 T3590 T3561 advcl are,known
R2347 T3591 T3590 nsubj cells,are
R2348 T3592 T3591 prep from,cells
R2349 T3593 T3594 det a,model
R2350 T3594 T3592 pobj model,from
R2351 T3595 T3594 amod homozygous,model
R2352 T3596 T3594 amod viable,model
R2353 T3597 T3598 nmod XpdXPCS,XPCS
R2354 T3598 T3594 nmod XPCS,model
R2355 T3599 T3598 punct /,XPCS
R2356 T3600 T3601 punct (,G602D
R2357 T3601 T3598 parataxis G602D,XPCS
R2358 T3602 T3601 compound XPDG602D,G602D
R2359 T3603 T3601 punct /,G602D
R2360 T3604 T3601 punct ),G602D
R2361 T3605 T3594 compound mouse,model
R2362 T3606 T3607 punct (,4A
R2363 T3607 T3590 parataxis 4A,are
R2364 T3608 T3607 compound Figure,4A
R2365 T3609 T3607 punct ", ",4A
R2366 T3610 T3611 amod dotted,line
R2367 T3611 T3607 appos line,4A
R2368 T3612 T3607 punct ),4A
R2369 T3613 T3614 punct [,23
R2370 T3614 T3561 parataxis 23,known
R2371 T3615 T3614 punct ],23
R2372 T3616 T3561 punct .,known
R2373 T3618 T3619 advmod Thus,represents
R2374 T3620 T3619 punct ", ",represents
R2375 T3621 T3622 det the,survival
R2376 T3622 T3619 nsubj survival,represents
R2377 T3623 T3622 prep of,survival
R2378 T3624 T3625 nmod XpdTTD,†XPCS
R2379 T3625 T3627 nmod †XPCS,cells
R2380 T3626 T3625 punct /,†XPCS
R2381 T3627 T3623 pobj cells,of
R2382 T3628 T3625 punct (,†XPCS
R2383 T3629 T3625 cc and,†XPCS
R2384 T3630 T3631 compound XpdTTD,†XP
R2385 T3631 T3625 conj †XP,†XPCS
R2386 T3632 T3631 punct /,†XP
R2387 T3633 T3627 punct ),cells
R2388 T3634 T3619 advmod likely,represents
R2389 T3635 T3636 det a,level
R2390 T3636 T3619 dobj level,represents
R2391 T3637 T3636 prep of,level
R2392 T3638 T3639 compound UV,resistance
R2393 T3639 T3637 pobj resistance,of
R2394 T3640 T3641 dep that,impart
R2395 T3641 T3636 relcl impart,level
R2396 T3642 T3643 preconj neither,allele
R2397 T3643 T3641 nsubj allele,impart
R2398 T3644 T3643 amod mutant,allele
R2399 T3645 T3641 aux can,impart
R2400 T3646 T3641 prep on,impart
R2401 T3647 T3648 poss its,own
R2402 T3648 T3646 pobj own,on
R2403 T3649 T3650 punct (,Table
R2404 T3650 T3619 parataxis Table,represents
R2405 T3651 T3650 nummod 2,Table
R2406 T3652 T3650 punct ),Table
R2407 T3653 T3619 punct .,represents
R2408 T3655 T3656 amod Significant,effects
R2409 T3656 T3657 nsubjpass effects,observed
R2410 T3658 T3656 prep of,effects
R2411 T3659 T3660 compound compound,heterozygosity
R2412 T3660 T3658 pobj heterozygosity,of
R2413 T3661 T3656 prep on,effects
R2414 T3662 T3663 compound NER,subpathways
R2415 T3663 T3661 pobj subpathways,on
R2416 T3664 T3656 amod relative,effects
R2417 T3665 T3664 prep to,relative
R2418 T3666 T3667 compound XpdTTD,KO
R2419 T3667 T3669 compound KO,cells
R2420 T3668 T3667 punct /,KO
R2421 T3669 T3665 pobj cells,to
R2422 T3670 T3657 auxpass were,observed
R2423 T3671 T3657 prep in,observed
R2424 T3672 T3673 compound XpdTTD,†XP
R2425 T3673 T3675 compound †XP,cells
R2426 T3674 T3673 punct /,†XP
R2427 T3675 T3671 pobj cells,in
R2428 T3676 T3671 cc but,in
R2429 T3677 T3678 advmod only,for
R2430 T3678 T3671 conj for,in
R2431 T3679 T3680 compound UV,UDS
R2432 T3680 T3682 compound UDS,activity
R2433 T3681 T3680 punct -,UDS
R2434 T3682 T3678 pobj activity,for
R2435 T3683 T3657 punct .,observed
R2436 T3685 T3686 advmod Finally,exhibited
R2437 T3687 T3686 punct ", ",exhibited
R2438 T3688 T3686 nsubj none,exhibited
R2441 T3691 T3689 pobj combinations,of
R2442 T3692 T3691 amod mutant,combinations
R2443 T3693 T3691 compound TFIIH,combinations
R2444 T3694 T3691 punct (,combinations
R2445 T3695 T3691 acl carrying,combinations
R2446 T3696 T3695 dobj alterations,carrying
R2447 T3697 T3696 acl associated,alterations
R2448 T3698 T3697 prep with,associated
R2449 T3699 T3698 pobj TTD,with
R2450 T3700 T3701 punct [,XPDR722W
R2451 T3701 T3699 parataxis XPDR722W,TTD
R2452 T3702 T3701 punct ],XPDR722W
R2453 T3703 T3699 punct ", ",TTD
R2454 T3704 T3699 conj XPCS,TTD
R2455 T3705 T3706 punct [,XPDG602D
R2456 T3706 T3704 parataxis XPDG602D,XPCS
R2457 T3707 T3706 punct ],XPDG602D
R2458 T3708 T3704 punct ", ",XPCS
R2459 T3709 T3704 cc or,XPCS
R2460 T3710 T3704 conj XP,XPCS
R2461 T3711 T3712 punct [,XPDR683W
R2462 T3712 T3710 parataxis XPDR683W,XP
R2463 T3713 T3712 punct ],XPDR683W
R2464 T3714 T3686 punct ),exhibited
R2465 T3715 T3686 dobj synergism,exhibited
R2466 T3716 T3686 prep in,exhibited
R2467 T3717 T3718 det an,reaction
R2468 T3718 T3716 pobj reaction,in
R2469 T3719 T3720 advmod in,vitro
R2470 T3720 T3718 amod vitro,reaction
R2471 T3721 T3718 compound NER,reaction
R2472 T3722 T3718 acl reconstituted,reaction
R2473 T3723 T3722 prep with,reconstituted
R2474 T3724 T3725 amod different,complexes
R2475 T3725 T3723 pobj complexes,with
R2476 T3726 T3725 amod mutant,complexes
R2477 T3727 T3725 compound TFIIH,complexes
R2478 T3728 T3729 punct (,4D
R2479 T3729 T3686 parataxis 4D,exhibited
R2480 T3730 T3729 compound Figure,4D
R2481 T3731 T3729 punct ),4D
R2482 T3732 T3686 punct .,exhibited
R2483 T3734 T3735 advcl Taken,are
R2484 T3736 T3734 advmod together,Taken
R2485 T3737 T3735 punct ", ",are
R2486 T3738 T3739 det these,data
R2487 T3739 T3735 nsubj data,are
R2488 T3740 T3735 acomp consistent,are
R2489 T3741 T3740 prep with,consistent
R2490 T3742 T3743 amod interallelic,complementation
R2491 T3743 T3741 pobj complementation,with
R2492 T3744 T3743 prep of,complementation
R2493 T3745 T3746 compound UV,sensitivity
R2494 T3746 T3744 pobj sensitivity,of
R2495 T3747 T3743 prep in,complementation
R2496 T3748 T3747 pobj cells,in
R2497 T3749 T3735 cc but,are
R2498 T3750 T3735 conj underscore,are
R2499 T3751 T3752 det the,lack
R2500 T3752 T3750 dobj lack,underscore
R2501 T3753 T3752 prep of,lack
R2502 T3754 T3755 det any,correlation
R2503 T3755 T3753 pobj correlation,of
R2504 T3756 T3755 prep between,correlation
R2505 T3757 T3758 npadvmod UV,related
R2506 T3758 T3760 amod related,characteristics
R2507 T3759 T3758 punct -,related
R2508 T3760 T3756 pobj characteristics,between
R2509 T3761 T3760 compound repair,characteristics
R2510 T3762 T3760 cc and,characteristics
R2511 T3763 T3764 compound TTD,phenotypes
R2512 T3764 T3760 conj phenotypes,characteristics
R2513 T3765 T3764 compound progeroid,phenotypes
R2514 T3766 T3755 prep in,correlation
R2515 T3767 T3768 compound animal,models
R2516 T3768 T3766 pobj models,in
R2517 T3769 T3735 punct .,are
R2572 T3867 T3865 pobj levels,of
R2573 T3868 T3867 prep in,levels
R2574 T3869 T3870 amod primary,fibroblasts
R2575 T3870 T3868 pobj fibroblasts,in
R2576 T3871 T3870 prep from,fibroblasts
R2577 T3872 T3871 pobj patients,from
R2578 T3873 T3872 prep with,patients
R2579 T3874 T3873 pobj TTD,with
R2580 T3875 T3860 prep compared,reduction
R2581 T3876 T3875 prep with,compared
R2582 T3877 T3878 compound wt,controls
R2583 T3878 T3876 pobj controls,with
R2584 T3879 T3860 prep due,reduction
R2585 T3880 T3879 pcomp to,due
R2586 T3881 T3882 amod reduced,stability
R2587 T3882 T3879 pobj stability,due
R2588 T3883 T3884 punct [,17
R2589 T3884 T3849 parataxis 17,shown
R2590 T3885 T3884 nummod 16,17
R2591 T3886 T3884 punct ",",17
R2592 T3887 T3884 punct ],17
R2593 T3888 T3849 punct .,shown
R2594 T3890 T3891 prep Despite,reduced
R2595 T3892 T3890 pobj overexpression,Despite
R2596 T3893 T3892 prep of,overexpression
R2597 T3894 T3893 pobj mRNA,of
R2598 T3895 T3894 prep from,mRNA
R2599 T3896 T3897 det the,allele
R2600 T3897 T3895 pobj allele,from
R2601 T3898 T3897 compound XpdTTD,allele
R2602 T3899 T3892 amod relative,overexpression
R2603 T3900 T3899 prep to,relative
R2604 T3901 T3902 det the,allele
R2605 T3902 T3900 pobj allele,to
R2606 T3903 T3902 compound wt,allele
R2607 T3904 T3905 punct (,1E
R2608 T3905 T3892 parataxis 1E,overexpression
R2609 T3906 T3905 compound Figure,1E
R2610 T3907 T3905 punct ),1E
R2611 T3908 T3891 punct ", ",reduced
R2612 T3909 T3910 compound TFIIH,levels
R2613 T3910 T3891 nsubjpass levels,reduced
R2614 T3911 T3910 compound protein,levels
R2615 T3912 T3891 auxpass were,reduced
R2616 T3913 T3891 prep by,reduced
R2617 T3914 T3915 nummod 50,%
R2618 T3915 T3913 pobj %,by
R2619 T3916 T3891 prep in,reduced
R2620 T3917 T3918 amod primary,fibroblasts
R2621 T3918 T3916 pobj fibroblasts,in
R2622 T3919 T3918 compound mouse,fibroblasts
R2623 T3920 T3921 compound XpdTTD,TTD
R2624 T3921 T3918 compound TTD,fibroblasts
R2625 T3922 T3921 punct /,TTD
R2626 T3923 T3924 punct (,4E
R2627 T3924 T3891 parataxis 4E,reduced
R2628 T3925 T3924 compound Figure,4E
R2629 T3926 T3924 cc and,4E
R2630 T3927 T3924 conj 4F,4E
R2631 T3928 T3924 punct ),4E
R2632 T3929 T3891 punct ", ",reduced
R2633 T3930 T3931 advmod thereby,mimicking
R2634 T3931 T3891 advcl mimicking,reduced
R2635 T3932 T3933 det the,situation
R2636 T3933 T3931 dobj situation,mimicking
R2637 T3934 T3931 prep in,mimicking
R2638 T3935 T3936 amod human,patients
R2639 T3936 T3934 pobj patients,in
R2640 T3937 T3936 prep with,patients
R2641 T3938 T3937 pobj TTD,with
R2642 T3939 T3891 punct .,reduced
R2643 T3941 T3942 prep In,observed
R2644 T3943 T3941 pobj accordance,In
R2645 T3944 T3943 prep with,accordance
R2646 T3945 T3946 det the,dosage
R2647 T3946 T3944 pobj dosage,with
R2648 T3947 T3946 compound gene,dosage
R2649 T3948 T3942 punct ", ",observed
R2650 T3949 T3950 det a,reduction
R2651 T3950 T3942 nsubjpass reduction,observed
R2652 T3951 T3950 amod further,reduction
R2653 T3952 T3950 prep of,reduction
R2654 T3953 T3954 quantmod up,70
R2655 T3954 T3956 nummod 70,%
R2656 T3955 T3954 quantmod to,70
R2657 T3956 T3952 pobj %,of
R2658 T3957 T3956 prep of,%
R2659 T3958 T3959 det the,level
R2660 T3959 T3957 pobj level,of
R2661 T3960 T3959 compound wt,level
R2662 T3961 T3942 auxpass was,observed
R2663 T3962 T3942 prep in,observed
R2664 T3963 T3964 amod hemizygous,cells
R2665 T3964 T3962 pobj cells,in
R2666 T3965 T3966 compound XpdTTD,KO
R2667 T3966 T3964 compound KO,cells
R2668 T3967 T3966 punct /,KO
R2669 T3968 T3942 punct .,observed
R2670 T3970 T3971 advcl Consistent,was
R2671 T3972 T3970 prep with,Consistent
R2672 T3973 T3974 amod low,levels
R2673 T3974 T3972 pobj levels,with
R2674 T3975 T3976 compound mRNA,expression
R2675 T3976 T3974 compound expression,levels
R2676 T3977 T3971 punct ", ",was
R2677 T3978 T3979 preconj neither,allele
R2678 T3979 T3971 nsubj allele,was
R2679 T3980 T3981 det the,Xpd†XPCS
R2680 T3981 T3979 nmod Xpd†XPCS,allele
R2681 T3982 T3981 cc nor,Xpd†XPCS
R2682 T3983 T3984 det the,Xpd†XP
R2683 T3984 T3981 conj Xpd†XP,Xpd†XPCS
R2684 T3985 T3971 acomp able,was
R2685 T3986 T3987 aux to,restore
R2686 T3987 T3985 xcomp restore,able
R2687 T3988 T3989 compound TFIIH,abundance
R2688 T3989 T3987 dobj abundance,restore
R2689 T3990 T3987 prep to,restore
R2690 T3991 T3992 compound wt,levels
R2691 T3992 T3990 pobj levels,to
R2692 T3993 T3987 prep in,restore
R2693 T3994 T3995 compound XpdTTD,cells
R2694 T3995 T3993 pobj cells,in
R2695 T3996 T3995 compound compound,cells
R2696 T3997 T3995 compound heterozygote,cells
R2697 T3998 T3999 punct (,4E
R2698 T3999 T3971 parataxis 4E,was
R2699 T4000 T3999 compound Figure,4E
R2700 T4001 T3999 cc and,4E
R2701 T4002 T3999 conj 4F,4E
R2702 T4003 T3999 punct ),4E
R2703 T4004 T3971 punct .,was
R2704 T4006 T4007 advmod Thus,were
R2705 T4008 T4007 punct ", ",were
R2706 T4009 T4010 det the,survival
R2707 T4010 T4007 nsubj survival,were
R2708 T4011 T4010 amod improved,survival
R2709 T4012 T4010 compound UV,survival
R2710 T4013 T4010 acl observed,survival
R2711 T4014 T4013 prep in,observed
R2712 T4015 T4016 compound compound,cells
R2713 T4016 T4014 pobj cells,in
R2714 T4017 T4016 compound heterozygote,cells
R2715 T4018 T4019 punct (,4A
R2716 T4019 T4013 parataxis 4A,observed
R2717 T4020 T4019 compound Figure,4A
R2718 T4021 T4019 punct ),4A
R2719 T4022 T4013 cc and,observed
R2720 T4023 T4024 advmod likely,rescue
R2721 T4024 T4013 conj rescue,observed
R2722 T4025 T4024 det the,rescue
R2723 T4026 T4024 prep of,rescue
R2724 T4027 T4028 compound TTD,symptoms
R2725 T4028 T4026 pobj symptoms,of
R2726 T4029 T4028 compound progeroid,symptoms
R2727 T4030 T4031 punct (,Figure
R2728 T4031 T4024 parataxis Figure,rescue
R2729 T4032 T4031 nummod 3,Figure
R2730 T4033 T4031 punct ),Figure
R2731 T4034 T4007 neg not,were
R2732 T4035 T4007 prep due,were
R2733 T4036 T4035 pcomp to,due
R2734 T4037 T4035 pobj normalisation,due
R2735 T4038 T4037 prep of,normalisation
R2736 T4039 T4040 compound TFIIH,levels
R2737 T4040 T4038 pobj levels,of
R2738 T4041 T4007 punct ", ",were
R2739 T4042 T4007 advcl suggesting,were
R2740 T4043 T4044 advmod a,qualitative
R2741 T4044 T4045 amod qualitative,effect
R2742 T4045 T4042 dobj effect,suggesting
R2743 T4046 T4047 advmod rather,than
R2744 T4047 T4044 cc than,qualitative
R2745 T4048 T4049 advmod a,quantitative
R2746 T4049 T4044 conj quantitative,qualitative
R2747 T4050 T4045 prep on,effect
R2748 T4051 T4052 det these,phenotypes
R2749 T4052 T4050 pobj phenotypes,on
R2750 T4053 T4054 advmod in,vivo
R2751 T4054 T4045 advmod vivo,effect
R2752 T4055 T4007 punct .,were
R2753 T4057 T4058 prep In,affect
R2754 T4059 T4057 pobj contrast,In
R2755 T4060 T4058 punct ", ",affect
R2756 T4061 T4062 det the,level
R2757 T4062 T4058 nsubj level,affect
R2758 T4063 T4062 prep of,level
R2759 T4064 T4065 compound XPCS,expression
R2760 T4065 T4063 pobj expression,of
R2761 T4066 T4065 compound mRNA,expression
R2762 T4067 T4058 aux did,affect
R2763 T4068 T4069 det the,ability
R2764 T4069 T4058 dobj ability,affect
R2765 T4070 T4069 prep of,ability
R2766 T4071 T4072 det the,protein
R2767 T4072 T4070 pobj protein,of
R2768 T4073 T4072 amod encoded,protein
R2769 T4074 T4072 punct (,protein
R2770 T4075 T4072 appos XPDG602D,protein
R2771 T4076 T4069 punct ),ability
R2772 T4077 T4078 aux to,restore
R2773 T4078 T4069 acl restore,ability
R2774 T4079 T4080 det the,phenotype
R2775 T4080 T4078 dobj phenotype,restore
R2776 T4081 T4080 compound TTD,phenotype
R2777 T4082 T4080 compound hair,phenotype
R2778 T4083 T4078 prep to,restore
R2779 T4084 T4083 amod normal,to
R2780 T4085 T4058 punct .,affect
R2781 T4087 T4088 advmod Notably,had
R2782 T4089 T4088 punct ", ",had
R2783 T4090 T4091 compound XpdTTD, †XPCS
R2784 T4091 T4093 compound  †XPCS,animals
R2785 T4092 T4091 punct /, †XPCS
R2786 T4093 T4088 nsubj animals,had
R2787 T4094 T4095 det a,phenotype
R2788 T4095 T4088 dobj phenotype,had
R2789 T4096 T4095 amod partial,phenotype
R2790 T4097 T4095 compound TTD,phenotype
R2791 T4098 T4095 compound hair,phenotype
R2792 T4099 T4095 punct ", ",phenotype
R2793 T4100 T4095 acl correlating,phenotype
R2794 T4101 T4100 prep with,correlating
R2795 T4102 T4103 amod low,levels
R2796 T4103 T4101 pobj levels,with
R2797 T4104 T4103 prep of,levels
R2798 T4105 T4106 compound Xpd†XPCS,expression
R2799 T4106 T4104 pobj expression,of
R2800 T4107 T4088 punct ", ",had
R2801 T4108 T4109 mark whereas,had
R2802 T4109 T4088 advcl had,had
R2803 T4110 T4111 compound XpdTTD,XPCS
R2804 T4111 T4113 compound XPCS,animals
R2805 T4112 T4111 punct /,XPCS
R2806 T4113 T4109 nsubj animals,had
R2807 T4114 T4115 compound wt,hair
R2808 T4115 T4109 dobj hair,had
R2809 T4116 T4115 punct ", ",hair
R2810 T4117 T4115 acl correlating,hair
R2811 T4118 T4117 prep with,correlating
R2827 T4134 T4088 punct .,had
R2828 T4136 T4137 advmod Thus,affected
R2829 T4138 T4137 punct ", ",affected
R2830 T4139 T4140 det the,range
R2831 T4140 T4137 nsubj range,affected
R2832 T4141 T4140 prep of,range
R2833 T4142 T4143 compound expression,levels
R2834 T4143 T4141 pobj levels,of
R2835 T4144 T4140 prep from,range
R2836 T4145 T4146 det these,alleles
R2837 T4146 T4144 pobj alleles,from
R2838 T4147 T4146 nummod two,alleles
R2839 T4148 T4146 amod mutant,alleles
R2840 T4149 T4150 poss their,ability
R2841 T4150 T4137 dobj ability,affected
R2842 T4151 T4152 aux to,complement
R2843 T4152 T4150 acl complement,ability
R2844 T4153 T4154 det some,phenotypes
R2845 T4154 T4152 dobj phenotypes,complement
R2846 T4155 T4156 punct (,hair
R2847 T4156 T4154 parataxis hair,phenotypes
R2848 T4157 T4156 punct ),hair
R2849 T4158 T4137 punct .,affected
R2850 T4160 T4161 det An,overview
R2851 T4161 T4162 nsubjpass overview,presented
R2852 T4163 T4161 prep of,overview
R2853 T4164 T4165 det the,relationships
R2854 T4165 T4163 pobj relationships,of
R2855 T4166 T4165 amod functional,relationships
R2856 T4167 T4165 prep between,relationships
R2857 T4168 T4169 compound Xpd,alleles
R2858 T4169 T4167 pobj alleles,between
R2859 T4170 T4169 punct ", ",alleles
R2860 T4171 T4169 conj phenotypes,alleles
R2861 T4172 T4171 punct ", ",phenotypes
R2862 T4173 T4171 cc and,phenotypes
R2863 T4174 T4175 det the,function
R2864 T4175 T4171 conj function,phenotypes
R2865 T4176 T4175 amod presumed,function
R2866 T4177 T4175 amod underlying,function
R2867 T4178 T4175 compound TFIIH,function
R2868 T4179 T4165 prep in,relationships
R2869 T4180 T4179 pobj mice,in
R2870 T4181 T4180 cc and,mice
R2871 T4182 T4180 conj cells,mice
R2872 T4183 T4162 auxpass is,presented
R2873 T4184 T4162 prep in,presented
R2874 T4185 T4184 pobj Table,in
R2875 T4186 T4185 nummod 2,Table
R2876 T4187 T4162 punct .,presented
R2877 T4260 T4259 prep of,Dissection
R2878 T4261 T4262 amod Biallelic,Effects
R2879 T4262 T4260 pobj Effects,of
R2880 T4263 T4259 prep from,Dissection
R2881 T4264 T4265 amod other,Determinants
R2882 T4265 T4263 pobj Determinants,from
R2883 T4266 T4265 prep of,Determinants
R2884 T4267 T4266 pobj Phenotype,of
R2885 T4269 T4270 mark Although,postulated
R2886 T4270 T4293 advcl postulated,been
R2887 T4271 T4272 amod phenotypic,consequences
R2888 T4272 T4270 nsubjpass consequences,postulated
R2889 T4273 T4272 punct ", ",consequences
R2890 T4274 T4272 acl referred,consequences
R2891 T4275 T4274 prep to,referred
R2892 T4276 T4274 advmod here,referred
R2893 T4277 T4274 prep as,referred
R2894 T4278 T4279 amod biallelic,effects
R2895 T4279 T4277 pobj effects,as
R2896 T4280 T4272 punct ", ",consequences
R2897 T4281 T4272 acl resulting,consequences
R2898 T4282 T4281 prep from,resulting
R2899 T4283 T4284 nummod two,alleles
R2900 T4284 T4282 pobj alleles,from
R2901 T4285 T4284 amod different,alleles
R2902 T4286 T4284 amod mutant,alleles
R2903 T4287 T4284 prep in,alleles
R2904 T4288 T4289 compound compound,patients
R2905 T4289 T4287 pobj patients,in
R2906 T4290 T4289 compound heterozygote,patients
R2907 T4291 T4270 aux have,postulated
R2908 T4292 T4270 auxpass been,postulated
R2909 T4294 T4293 punct ", ",been
R2910 T4295 T4296 amod such,effects
R2911 T4296 T4293 nsubj effects,been
R2912 T4297 T4293 aux have,been
R2913 T4298 T4293 advmod historically,been
R2914 T4299 T4293 acomp difficult,been
R2915 T4300 T4301 aux to,distinguish
R2916 T4301 T4299 xcomp distinguish,difficult
R2917 T4302 T4301 prep from,distinguish
R2918 T4303 T4304 det the,influence
R2919 T4304 T4302 pobj influence,from
R2920 T4305 T4304 prep of,influence
R2921 T4306 T4305 pobj environment,of
R2922 T4307 T4306 cc and,environment
R2923 T4308 T4309 amod genetic,background
R2924 T4309 T4306 conj background,environment
R2925 T4310 T4293 punct .,been
R2926 T4312 T4313 nsubj We,used
R2927 T4314 T4315 det a,system
R2928 T4315 T4313 dobj system,used
R2929 T4316 T4317 advmod genetically,defined
R2930 T4317 T4315 amod defined,system
R2931 T4318 T4315 amod mammalian,system
R2932 T4319 T4315 compound model,system
R2933 T4320 T4313 prep under,used
R2934 T4321 T4322 amod controlled,conditions
R2935 T4322 T4320 pobj conditions,under
R2936 T4323 T4322 amod environmental,conditions
R2937 T4324 T4325 aux to,reveal
R2938 T4325 T4313 advcl reveal,used
R2939 T4326 T4327 amod phenotypic,effects
R2940 T4327 T4325 dobj effects,reveal
R2941 T4328 T4327 amod attributable,effects
R2942 T4329 T4330 advmod specifically,to
R2943 T4330 T4328 prep to,attributable
R2944 T4331 T4330 pobj combinations,to
R2945 T4332 T4331 prep of,combinations
R2946 T4333 T4334 advmod differentially,mutated
R2947 T4334 T4335 amod mutated,alleles
R2948 T4335 T4332 pobj alleles,of
R2949 T4336 T4335 compound Xpd,alleles
R2950 T4337 T4313 punct .,used
R2951 T4339 T4340 det The,effects
R2952 T4340 T4343 nsubj effects,were
R2953 T4341 T4340 amod observed,effects
R2954 T4342 T4340 amod biallelic,effects
R2955 T4344 T4343 prep of,were
R2956 T4345 T4346 nummod three,types
R2957 T4346 T4344 pobj types,of
R2958 T4347 T4346 amod general,types
R2959 T4348 T4343 punct .,were
R2960 T4350 T4351 prep In,determined
R2961 T4352 T4353 det the,first
R2962 T4353 T4350 pobj first,In
R2963 T4354 T4351 punct ", ",determined
R2964 T4355 T4356 det the,allele
R2965 T4356 T4351 nsubj allele,determined
R2966 T4357 T4356 acl associated,allele
R2967 T4358 T4357 prep in,associated
R2968 T4359 T4360 det a,state
R2969 T4360 T4358 pobj state,in
R2970 T4361 T4360 amod homozygous,state
R2971 T4362 T4357 prep with,associated
R2972 T4363 T4364 det a,phenotype
R2973 T4364 T4362 pobj phenotype,with
R2974 T4365 T4366 advmod closer,to
R2975 T4366 T4364 amod to,phenotype
R2976 T4367 T4366 pobj wt,to
R2977 T4368 T4351 advmod singularly,determined
R2978 T4369 T4370 det the,outcome
R2979 T4370 T4351 dobj outcome,determined
R2980 T4371 T4370 amod phenotypic,outcome
R2981 T4372 T4351 punct ", ",determined
R2982 T4373 T4374 det a,phenomenon
R2983 T4374 T4351 npadvmod phenomenon,determined
R2984 T4375 T4376 advmod widely,known
R2985 T4376 T4374 acl known,phenomenon
R2986 T4377 T4376 prep in,known
R2987 T4378 T4379 amod human,disease
R2988 T4379 T4377 pobj disease,in
R2989 T4380 T4379 amod recessive,disease
R2990 T4381 T4351 punct .,determined
R2991 T4383 T4384 mark Because,functioned
R2992 T4384 T4388 advcl functioned,call
R2993 T4385 T4386 det these,alleles
R2994 T4386 T4384 nsubj alleles,functioned
R2995 T4387 T4386 compound Xpd,alleles
R2996 T4389 T4384 prep at,functioned
R2997 T4390 T4389 cc or,at
R2998 T4391 T4389 conj near,at
R2999 T4392 T4393 compound wt,levels
R3000 T4393 T4391 pobj levels,near
R3001 T4394 T4384 prep with,functioned
R3002 T4395 T4394 pobj respect,with
R3003 T4396 T4395 prep to,respect
R3004 T4397 T4398 det a,function
R3005 T4398 T4396 pobj function,to
R3006 T4399 T4398 amod particular,function
R3007 T4400 T4388 punct ", ",call
R3008 T4401 T4388 nsubj we,call
R3009 T4402 T4403 det these,effects
R3010 T4403 T4388 dobj effects,call
R3011 T4404 T4388 punct “,call
R3012 T4405 T4388 oprd dominant,call
R3013 T4406 T4388 punct ”,call
R3014 T4407 T4388 punct .,call
R3015 T4409 T4410 amod Such,alleles
R3016 T4410 T4411 nsubjpass alleles,referred
R3017 T4412 T4411 aux can,referred
R3018 T4413 T4411 advmod also,referred
R3019 T4414 T4411 auxpass be,referred
R3020 T4415 T4411 prep to,referred
R3021 T4416 T4411 prep as,referred
R3022 T4417 T4418 punct “,alleles
R3023 T4418 T4416 pobj alleles,as
R3024 T4419 T4418 nmod separation,alleles
R3025 T4420 T4419 prep of,separation
R3026 T4421 T4420 pobj function,of
R3027 T4422 T4418 punct ”,alleles
R3028 T4423 T4411 punct ", ",referred
R3029 T4424 T4425 mark because,allow
R3030 T4425 T4411 advcl allow,referred
R3031 T4426 T4425 nsubj they,allow
R3032 T4427 T4425 dobj dissection,allow
R3033 T4428 T4427 prep of,dissection
R3034 T4429 T4430 det the,roles
R3035 T4430 T4428 pobj roles,of
R3036 T4431 T4430 prep of,roles
R3037 T4432 T4433 amod multifunctional,proteins
R3038 T4433 T4431 pobj proteins,of
R3039 T4434 T4425 prep in,allow
R3040 T4435 T4436 amod specific,phenotypes
R3041 T4436 T4434 pobj phenotypes,in
R3042 T4437 T4411 punct .,referred
R3043 T4439 T4440 advmod Secondly,was
R3044 T4441 T4440 punct ", ",was
R3045 T4442 T4440 dep highlighting,was
R3046 T4443 T4444 det the,relevance
R3047 T4444 T4442 dobj relevance,highlighting
R3048 T4445 T4444 amod potential,relevance
R3049 T4446 T4444 prep of,relevance
R3050 T4447 T4448 amod current,findings
R3051 T4448 T4446 pobj findings,of
R3052 T4449 T4444 prep to,relevance
R3053 T4450 T4451 det all,organisms
R3054 T4451 T4449 pobj organisms,to
R3055 T4452 T4451 amod diploid,organisms
R3056 T4453 T4451 prep including,organisms
R3057 T4454 T4453 pobj humans,including
R3058 T4455 T4456 det the,observation
R3059 T4456 T4440 nsubj observation,was
R3060 T4457 T4458 mark that,shift
R3061 T4458 T4456 acl shift,observation
R3062 T4459 T4458 prep in,shift
R3063 T4460 T4461 nummod one,animal
R3064 T4461 T4459 pobj animal,in
R3065 T4462 T4461 nmod compound,animal
R3066 T4463 T4461 amod heterozygous,animal
R3067 T4464 T4458 punct ", ",shift
R3068 T4465 T4466 det the,relationship
R3069 T4466 T4458 nsubj relationship,shift
R3070 T4467 T4466 nmod Xpd,relationship
R3071 T4468 T4466 amod allelic,relationship
R3072 T4469 T4458 aux could,shift
R3073 T4470 T4458 prep from,shift
R3074 T4471 T4472 amod A dominant,a recessive
R3075 T4472 T4470 pobj a recessive,from
R3076 T4473 T4472 punct |,a recessive
R3077 T4474 T4470 prep to,from
R3078 T4475 T4476 amod A recessive,a dominant
R3079 T4476 T4474 pobj a dominant,to
R3080 T4477 T4476 punct |,a dominant
R3081 T4478 T4458 prep with,shift
R3082 T4479 T4478 pobj respect,with
R3083 T4480 T4479 prep to,respect
R3084 T4481 T4482 amod different,phenotypes
R3085 T4482 T4480 pobj phenotypes,to
R3086 T4483 T4458 prep in,shift
R3087 T4484 T4485 det a,manner
R3088 T4485 T4483 pobj manner,in
R3089 T4486 T4487 npadvmod time,dependent
R3090 T4487 T4485 amod dependent,manner
R3091 T4488 T4487 punct -,dependent
R3092 T4489 T4487 cc and,dependent
R3093 T4490 T4491 npadvmod tissue,specific
R3094 T4491 T4487 conj specific,dependent
R3095 T4492 T4491 punct -,specific
R3096 T4493 T4494 punct (,see
R3097 T4494 T4458 parataxis see,shift
R3098 T4495 T4496 advmod below,Table
R3099 T4496 T4494 dobj Table,see
R3100 T4497 T4496 cc and,Table
R3101 T4498 T4496 nummod 2,Table
R3102 T4499 T4494 punct ),see
R3103 T4500 T4440 punct .,was
R3104 T4502 T4503 prep In,produced
R3105 T4504 T4505 det the,type
R3106 T4505 T4502 pobj type,In
R3107 T4506 T4505 amod third,type
R3108 T4507 T4505 prep of,type
R3109 T4508 T4509 amod biallelic,effect
R3110 T4509 T4507 pobj effect,of
R3111 T4510 T4505 punct ", ",type
R3112 T4511 T4505 acl known,type
R3113 T4512 T4511 prep as,known
R3114 T4513 T4514 amod interallelic,complementation
R3115 T4514 T4512 pobj complementation,as
R3116 T4515 T4503 punct ", ",produced
R3117 T4516 T4517 nummod two,alleles
R3118 T4517 T4503 nsubj alleles,produced
R3119 T4518 T4517 amod mutant,alleles
R3120 T4519 T4520 det a,phenotype
R3121 T4520 T4503 dobj phenotype,produced
R3122 T4521 T4522 advmod closer,to
R3123 T4522 T4520 amod to,phenotype
R3124 T4523 T4522 pobj wt,to
R3125 T4524 T4525 mark than,alone
R3126 T4525 T4522 advcl alone,to
R3127 T4526 T4525 nsubj either,alone
R3128 T4527 T4525 aux could,alone
R3129 T4528 T4525 prep in,alone
R3130 T4529 T4530 det a,state
R3131 T4530 T4528 pobj state,in
R3132 T4531 T4532 advmod homo,hemizygous
R3133 T4532 T4530 amod hemizygous,state
R3134 T4533 T4532 punct -,hemizygous
R3135 T4534 T4532 cc or,hemizygous
R3136 T4535 T4503 punct .,produced
R3137 T4537 T4538 mark As,summarised
R3138 T4538 T4539 advcl summarised,observed
R3139 T4540 T4538 prep in,summarised
R3140 T4541 T4540 pobj Table,in
R3141 T4542 T4541 nummod 2,Table
R3142 T4543 T4539 punct ", ",observed
R3143 T4544 T4539 nsubjpass examples,observed
R3144 T4545 T4544 prep of,examples
R3145 T4546 T4547 det all,types
R3146 T4547 T4545 pobj types,of
R3147 T4548 T4547 prep of,types
R3148 T4549 T4550 amod biallelic,effects
R3149 T4550 T4548 pobj effects,of
R3150 T4551 T4539 auxpass were,observed
R3151 T4552 T4539 prep in,observed
R3152 T4553 T4554 det a,variety
R3153 T4554 T4552 pobj variety,in
R3154 T4555 T4554 prep of,variety
R3155 T4556 T4557 npadvmod Xpd,associated
R3156 T4557 T4559 amod associated,phenotypes
R3157 T4558 T4557 punct -,associated
R3158 T4559 T4555 pobj phenotypes,of
R3159 T4560 T4554 punct ", ",variety
R3160 T4561 T4554 acl ranging,variety
R3161 T4562 T4561 prep from,ranging
R3162 T4563 T4564 amod brittle,hair
R3163 T4564 T4562 pobj hair,from
R3164 T4565 T4562 prep to,from
R3165 T4566 T4567 amod segmental,progeria
R3166 T4567 T4565 pobj progeria,to
R3167 T4568 T4539 punct .,observed
R3180 T4806 T4805 prep in,TFIIH
R3181 T4807 T4806 pobj Transcription,in
R3182 T4808 T4807 cc and,Transcription
R3183 T4809 T4807 conj Repair,Transcription
R3184 T4810 T4805 punct : ,TFIIH
R3185 T4811 T4805 appos Mechanisms,TFIIH
R3186 T4812 T4811 prep of,Mechanisms
R3187 T4813 T4814 compound XPD,Pleiotropy
R3188 T4814 T4812 pobj Pleiotropy,of
R3189 T4815 T4814 compound Disease,Pleiotropy
R3190 T4817 T4818 nsubj We,observed
R3191 T4819 T4818 dobj differences,observed
R3192 T4820 T4819 prep in,differences
R3193 T4821 T4822 det the,ability
R3194 T4822 T4820 pobj ability,in
R3195 T4823 T4822 prep of,ability
R3196 T4824 T4823 pobj XpdTTD,of
R3197 T4825 T4824 cc versus,XpdTTD
R3198 T4826 T4827 amod homozygous,alleles
R3199 T4827 T4824 conj alleles,XpdTTD
R3200 T4828 T4827 amod lethal,alleles
R3201 T4829 T4827 nmod Xpd†XPCS,alleles
R3202 T4830 T4829 cc and,Xpd†XPCS
R3203 T4831 T4829 conj Xpd†XP,Xpd†XPCS
R3204 T4832 T4833 aux to,function
R3205 T4833 T4822 acl function,ability
R3206 T4834 T4833 prep in,function
R3207 T4835 T4836 nummod two,phenotypes
R3208 T4836 T4834 pobj phenotypes,in
R3209 T4837 T4838 npadvmod transcription,related
R3210 T4838 T4836 amod related,phenotypes
R3211 T4839 T4838 punct -,related
R3212 T4840 T4836 acl separated,phenotypes
R3213 T4841 T4840 prep in,separated
R3214 T4842 T4843 det the,organism
R3215 T4843 T4841 pobj organism,in
R3216 T4844 T4840 prep by,separated
R3217 T4845 T4846 preconj both,time
R3218 T4846 T4844 pobj time,by
R3219 T4847 T4846 cc and,time
R3220 T4848 T4846 conj space,time
R3221 T4849 T4819 punct : ,differences
R3222 T4850 T4851 amod embryonic,lethality
R3223 T4851 T4819 appos lethality,differences
R3224 T4852 T4851 cc and,lethality
R3225 T4853 T4854 amod terminal,differentiation
R3226 T4854 T4851 conj differentiation,lethality
R3227 T4855 T4854 prep of,differentiation
R3228 T4856 T4857 amod enucleating,skin
R3229 T4857 T4855 pobj skin,of
R3230 T4858 T4857 cc and,skin
R3231 T4859 T4860 compound blood,cells
R3232 T4860 T4857 conj cells,skin
R3233 T4861 T4818 punct .,observed
R3234 T4863 T4864 det The,lethality
R3235 T4864 T4869 nsubj lethality,reflects
R3236 T4865 T4866 nmod preblastocyst,stage
R3237 T4866 T4864 nmod stage,lethality
R3238 T4867 T4866 punct -,stage
R3239 T4868 T4864 amod homozygous,lethality
R3240 T4870 T4864 acl shared,lethality
R3241 T4871 T4870 agent by,shared
R3242 T4872 T4873 det the,alleles
R3243 T4873 T4871 pobj alleles,by
R3244 T4874 T4873 nmod XpdKO,alleles
R3245 T4875 T4874 punct ", ",XpdKO
R3246 T4876 T4874 conj Xpd†XPCS,XpdKO
R3247 T4877 T4876 punct ", ",Xpd†XPCS
R3248 T4878 T4876 cc and,Xpd†XPCS
R3249 T4879 T4876 conj Xpd†XP,Xpd†XPCS
R3250 T4880 T4881 advmod most,likely
R3251 T4881 T4869 advmod likely,reflects
R3252 T4882 T4883 det a,defect
R3253 T4883 T4869 dobj defect,reflects
R3254 T4884 T4883 prep in,defect
R3255 T4885 T4886 amod basal,transcription
R3256 T4886 T4884 pobj transcription,in
R3257 T4887 T4888 dep that,is
R3258 T4888 T4883 relcl is,defect
R3259 T4889 T4888 acomp incompatible,is
R3260 T4890 T4889 prep with,incompatible
R3261 T4891 T4890 pobj life,with
R3262 T4892 T4869 punct .,reflects
R3263 T4894 T4895 prep In,rescued
R3264 T4896 T4897 nmod XpdTTD, †XPCS
R3265 T4897 T4899 nmod  †XPCS,mice
R3266 T4898 T4897 punct /, †XPCS
R3267 T4899 T4894 pobj mice,In
R3268 T4900 T4897 cc and, †XPCS
R3269 T4901 T4902 compound XpdTTD, †XP
R3270 T4902 T4897 conj  †XP, †XPCS
R3271 T4903 T4902 punct /, †XP
R3272 T4904 T4899 nmod compound,mice
R3273 T4905 T4899 amod heterozygous,mice
R3274 T4906 T4895 punct ", ",rescued
R3275 T4907 T4908 amod embryonic,lethality
R3276 T4908 T4895 nsubjpass lethality,rescued
R3277 T4909 T4895 auxpass was,rescued
R3278 T4910 T4895 advmod fully,rescued
R3279 T4911 T4895 agent by,rescued
R3280 T4912 T4913 det the,allele
R3281 T4913 T4911 pobj allele,by
R3282 T4914 T4913 compound XpdTTD,allele
R3283 T4915 T4895 punct .,rescued
R3284 T4917 T4918 mark Because,rescued
R3285 T4918 T4924 advcl rescued,considered
R3286 T4919 T4920 amod embryonic,lethality
R3287 T4920 T4918 nsubjpass lethality,rescued
R3288 T4921 T4918 auxpass was,rescued
R3289 T4922 T4918 advmod also,rescued
R3290 T4923 T4918 advmod fully,rescued
R3291 T4925 T4918 prep in,rescued
R3292 T4926 T4927 nmod XpdTTD,KO
R3293 T4927 T4929 nmod KO,mice
R3294 T4928 T4927 punct /,KO
R3295 T4929 T4925 pobj mice,in
R3296 T4930 T4929 amod hemizygous,mice
R3297 T4931 T4924 punct ", ",considered
R3298 T4932 T4933 det the,allele
R3299 T4933 T4924 nsubjpass allele,considered
R3300 T4934 T4933 compound XpdTTD,allele
R3301 T4935 T4924 aux can,considered
R3302 T4936 T4924 auxpass be,considered
R3303 T4937 T4924 prep as,considered
R3304 T4938 T4937 pobj wt,as
R3305 T4939 T4938 cc and,wt
R3306 T4940 T4941 advmod thus,dominant
R3307 T4941 T4938 conj dominant,wt
R3308 T4942 T4941 prep to,dominant
R3309 T4943 T4942 pobj each,to
R3310 T4944 T4943 prep of,each
R3311 T4945 T4946 det the,alleles
R3312 T4946 T4944 pobj alleles,of
R3313 T4947 T4946 amod homozygous,alleles
R3314 T4948 T4946 amod lethal,alleles
R3315 T4949 T4950 punct (,XpdKO
R3316 T4950 T4946 parataxis XpdKO,alleles
R3317 T4951 T4950 punct ", ",XpdKO
R3318 T4952 T4950 conj Xpd†XPCS,XpdKO
R3319 T4953 T4952 punct ", ",Xpd†XPCS
R3320 T4954 T4952 cc and,Xpd†XPCS
R3321 T4955 T4952 conj Xpd†XP,Xpd†XPCS
R3322 T4956 T4950 punct ),XpdKO
R3323 T4957 T4941 prep with,dominant
R3324 T4958 T4957 pobj respect,with
R3325 T4959 T4958 prep to,respect
R3326 T4960 T4961 det this,phenotype
R3327 T4961 T4959 pobj phenotype,to
R3328 T4962 T4961 amod particular,phenotype
R3329 T4963 T4964 punct (,Table
R3330 T4964 T4924 parataxis Table,considered
R3331 T4965 T4964 nummod 2,Table
R3332 T4966 T4964 punct ),Table
R3333 T4967 T4924 punct .,considered
R3334 T4969 T4970 npadvmod TTD,specific
R3335 T4970 T4972 amod specific,features
R3336 T4971 T4970 punct -,specific
R3337 T4972 T4976 nsubjpass features,thought
R3338 T4973 T4972 amod cutaneous,features
R3339 T4974 T4973 cc and,cutaneous
R3340 T4975 T4973 conj anaemic,cutaneous
R3341 T4977 T4976 punct ", ",thought
R3342 T4978 T4976 prep on,thought
R3343 T4979 T4980 det the,hand
R3344 T4980 T4978 pobj hand,on
R3345 T4981 T4980 amod other,hand
R3346 T4982 T4976 punct ", ",thought
R3347 T4983 T4976 auxpass are,thought
R3348 T4984 T4985 aux to,result
R3349 T4985 T4976 xcomp result,thought
R3350 T4986 T4985 prep from,result
R3351 T4987 T4988 det a,kind
R3352 T4988 T4986 pobj kind,from
R3353 T4989 T4988 amod specific,kind
R3354 T4990 T4988 prep of,kind
R3355 T4991 T4992 amod transcriptional,insufficiency
R3356 T4992 T4990 pobj insufficiency,of
R3357 T4993 T4988 acl caused,kind
R3358 T4994 T4993 agent by,caused
R3359 T4995 T4994 pobj depletion,by
R3360 T4996 T4995 prep of,depletion
R3361 T4997 T4998 amod unstable,TFIIH
R3362 T4998 T4996 pobj TFIIH,of
R3363 T4999 T4995 prep during,depletion
R3364 T5000 T5001 det the,differentiation
R3365 T5001 T4999 pobj differentiation,during
R3366 T5002 T5001 amod terminal,differentiation
R3367 T5003 T5001 prep of,differentiation
R3368 T5004 T5005 nmod skin,cells
R3369 T5005 T5003 pobj cells,of
R3370 T5006 T5004 punct ", ",skin
R3371 T5007 T5008 compound hair,shaft
R3372 T5008 T5004 conj shaft,skin
R3373 T5009 T5008 punct -,shaft
R3374 T5010 T5008 punct ", ",shaft
R3375 T5011 T5008 cc and,shaft
R3376 T5012 T5008 conj blood,shaft
R3377 T5013 T5014 punct [,24
R3378 T5014 T4976 parataxis 24,thought
R3379 T5015 T5014 nummod 16,24
R3380 T5016 T5014 punct ",",24
R3381 T5017 T5014 punct ],24
R3382 T5018 T4976 punct .,thought
R3383 T5020 T5021 prep In,were
R3384 T5022 T5023 nmod compound,mice
R3385 T5023 T5020 pobj mice,In
R3386 T5024 T5023 amod heterozygous,mice
R3387 T5025 T5021 punct ", ",were
R3388 T5026 T5027 det both,alleles
R3389 T5027 T5021 nsubj alleles,were
R3390 T5028 T5027 amod homozygous,alleles
R3391 T5029 T5027 amod lethal,alleles
R3392 T5030 T5027 nmod Xpd†XPCS,alleles
R3393 T5031 T5030 cc and,Xpd†XPCS
R3394 T5032 T5030 conj Xpd†XP,Xpd†XPCS
R3395 T5033 T5021 acomp able,were
R3396 T5034 T5035 aux to,alleviate
R3397 T5035 T5033 xcomp alleviate,able
R3398 T5036 T5037 npadvmod XpdTTD,specific
R3399 T5037 T5039 amod specific,features
R3400 T5038 T5037 punct -,specific
R3401 T5039 T5035 dobj features,alleviate
R3402 T5040 T5039 amod cutaneous,features
R3403 T5041 T5040 cc and,cutaneous
R3404 T5042 T5040 conj anaemic,cutaneous
R3405 T5043 T5021 cc and,were
R3406 T5044 T5045 aux can,defined
R3407 T5045 T5021 conj defined,were
R3408 T5046 T5045 advmod thus,defined
R3409 T5047 T5045 auxpass be,defined
R3410 T5048 T5045 prep as,defined
R3411 T5049 T5048 amod dominant,as
R3412 T5050 T5045 prep over,defined
R3413 T5051 T5052 det the,allele
R3414 T5052 T5050 pobj allele,over
R3415 T5053 T5052 compound XpdTTD,allele
R3416 T5054 T5045 prep with,defined
R3417 T5055 T5054 pobj respect,with
R3418 T5056 T5055 prep to,respect
R3419 T5057 T5058 det these,phenotypes
R3420 T5058 T5056 pobj phenotypes,to
R3421 T5059 T5021 punct .,were
R3422 T5061 T5062 nsubj We,conclude
R3423 T5063 T5064 mark that,represent
R3424 T5064 T5062 ccomp represent,conclude
R3425 T5065 T5066 det the,defects
R3426 T5066 T5064 nsubj defects,represent
R3427 T5067 T5066 acl leading,defects
R3428 T5068 T5067 prep to,leading
R3429 T5069 T5070 amod embryonic,lethality
R3430 T5070 T5068 pobj lethality,to
R3431 T5071 T5070 cc and,lethality
R3432 T5072 T5073 amod aberrant,differentiation
R3433 T5073 T5070 conj differentiation,lethality
R3434 T5074 T5073 amod terminal,differentiation
R3435 T5075 T5073 prep of,differentiation
R3436 T5076 T5077 det the,skin
R3437 T5077 T5075 pobj skin,of
R3438 T5078 T5077 punct ", ",skin
R3439 T5079 T5077 conj hair,skin
R3440 T5080 T5079 punct ", ",hair
R3441 T5081 T5079 cc and,hair
R3442 T5082 T5079 conj blood,hair
R3443 T5083 T5084 nummod two,deficiencies
R3444 T5084 T5064 dobj deficiencies,represent
R3445 T5085 T5086 advmod qualitatively,different
R3446 T5086 T5084 amod different,deficiencies
R3447 T5087 T5085 cc and,qualitatively
R3448 T5088 T5087 punct /,and
R3449 T5089 T5087 cc or,and
R3450 T5090 T5085 conj quantitatively,qualitatively
R3451 T5091 T5084 amod transcriptional,deficiencies
R3452 T5092 T5062 punct .,conclude
R3453 T5094 T5095 prep During,is
R3454 T5096 T5097 amod early,development
R3455 T5097 T5094 pobj development,During
R3456 T5098 T5097 amod embryonic,development
R3457 T5099 T5095 punct ", ",is
R3458 T5100 T5095 nsubj XpdTTD,is
R3459 T5101 T5095 acomp dominant,is
R3460 T5102 T5101 prep over,dominant
R3461 T5103 T5104 det the,alleles
R3462 T5104 T5102 pobj alleles,over
R3463 T5105 T5104 nmod Xpd†XPCS,alleles
R3464 T5106 T5105 cc and,Xpd†XPCS
R3465 T5107 T5105 conj Xpd†XP,Xpd†XPCS
R3466 T5108 T5095 punct ", ",is
R3467 T5109 T5110 mark whereas,reversed
R3468 T5110 T5095 advcl reversed,is
R3469 T5111 T5110 advmod later,reversed
R3470 T5112 T5111 prep in,later
R3471 T5113 T5114 det the,ontogenesis
R3472 T5114 T5112 pobj ontogenesis,in
R3473 T5115 T5114 prep of,ontogenesis
R3474 T5116 T5115 pobj skin,of
R3475 T5117 T5116 punct ", ",skin
R3476 T5118 T5119 compound hair,shaft
R3477 T5119 T5116 conj shaft,skin
R3478 T5120 T5119 punct -,shaft
R3479 T5121 T5119 punct ", ",shaft
R3480 T5122 T5119 cc and,shaft
R3481 T5123 T5124 compound blood,cells
R3482 T5124 T5119 conj cells,shaft
R3483 T5125 T5110 punct ", ",reversed
R3484 T5126 T5127 det the,situation
R3485 T5127 T5110 nsubjpass situation,reversed
R3486 T5128 T5110 auxpass is,reversed
R3487 T5129 T5095 punct .,is
R3488 T5131 T5132 prep In,imparted
R3489 T5133 T5134 poss its,role
R3490 T5134 T5131 pobj role,In
R3491 T5135 T5134 prep in,role
R3492 T5136 T5137 det the,repair
R3493 T5137 T5135 pobj repair,in
R3494 T5138 T5137 prep of,repair
R3495 T5139 T5140 compound UV,photolesions
R3496 T5140 T5138 pobj photolesions,of
R3497 T5141 T5132 punct ", ",imparted
R3498 T5142 T5143 det the,allele
R3499 T5143 T5132 nsubj allele,imparted
R3500 T5144 T5143 compound Xpd†XPCS,allele
R3501 T5145 T5146 det a,benefit
R3502 T5146 T5132 dobj benefit,imparted
R3503 T5147 T5146 amod clear,benefit
R3504 T5148 T5146 compound UV,benefit
R3505 T5149 T5146 compound survival,benefit
R3506 T5150 T5146 prep over,benefit
R3507 T5151 T5152 det a,allele
R3508 T5152 T5150 pobj allele,over
R3509 T5153 T5152 amod single,allele
R3510 T5154 T5152 compound XpdTTD,allele
R3511 T5155 T5152 cc or,allele
R3512 T5156 T5157 nummod two,alleles
R3513 T5157 T5152 conj alleles,allele
R3514 T5158 T5157 compound XpdXPCS,alleles
R3515 T5159 T5146 amod independent,benefit
R3516 T5160 T5159 prep of,independent
R3517 T5161 T5162 compound expression,levels
R3518 T5162 T5160 pobj levels,of
R3519 T5163 T5132 punct ", ",imparted
R3520 T5164 T5165 dep which,is
R3521 T5165 T5132 advcl is,imparted
R3522 T5166 T5165 acomp consistent,is
R3523 T5167 T5166 prep with,consistent
R3524 T5168 T5169 amod interallelic,complementation
R3525 T5169 T5167 pobj complementation,with
R3526 T5170 T5132 punct .,imparted
R3527 T5172 T5173 advmod However,argues
R3528 T5174 T5173 punct ", ",argues
R3529 T5175 T5176 det the,observation
R3530 T5176 T5173 nsubj observation,argues
R3531 T5177 T5178 mark that,improved
R3532 T5178 T5176 acl improved,observation
R3533 T5179 T5180 det no,parameters
R3534 T5180 T5178 nsubjpass parameters,improved
R3535 T5181 T5180 amod other,parameters
R3536 T5182 T5180 amod cellular,parameters
R3537 T5183 T5182 cc or,cellular
R3538 T5184 T5182 conj biochemical,cellular
R3539 T5185 T5186 npadvmod UV,related
R3540 T5186 T5180 amod related,parameters
R3541 T5187 T5186 punct -,related
R3542 T5188 T5178 auxpass were,improved
R3543 T5189 T5178 prep in,improved
R3544 T5190 T5191 compound XpdTTD, †XPCS
R3545 T5191 T5189 pobj  †XPCS,in
R3546 T5192 T5191 punct /, †XPCS
R3547 T5193 T5173 prep against,argues
R3548 T5194 T5193 pobj complementation,against
R3549 T5195 T5194 prep of,complementation
R3550 T5196 T5197 det this,activity
R3551 T5197 T5195 pobj activity,of
R3552 T5198 T5197 compound repair,activity
R3553 T5199 T5194 prep in,complementation
R3554 T5200 T5201 det the,rescue
R3555 T5201 T5199 pobj rescue,in
R3556 T5202 T5201 prep of,rescue
R3557 T5203 T5204 nmod TTD,symptoms
R3558 T5204 T5202 pobj symptoms,of
R3559 T5205 T5204 amod progeroid,symptoms
R3560 T5206 T5207 advmod in,vivo
R3561 T5207 T5201 advmod vivo,rescue
R3562 T5208 T5173 punct .,argues
R3565 T5295 T5296 amod Interallelic,Complementation
R3566 T5297 T5296 cc and,Complementation
R3567 T5298 T5299 compound XPD,Function
R3568 T5299 T5296 conj Function,Complementation
R3569 T5301 T5302 dep What,tell
R3570 T5303 T5302 aux does,tell
R3571 T5304 T5305 amod interallelic,complementation
R3572 T5305 T5302 nsubj complementation,tell
R3573 T5306 T5302 dobj us,tell
R3574 T5307 T5302 prep about,tell
R3575 T5308 T5309 det the,mechanism
R3576 T5309 T5307 pobj mechanism,about
R3577 T5310 T5309 prep of,mechanism
R3578 T5311 T5312 compound XPD,function
R3579 T5312 T5310 pobj function,of
R3580 T5313 T5302 punct ?,tell
R3581 T5315 T5316 amod Interallelic,complementation
R3582 T5316 T5317 nsubjpass complementation,observed
R3583 T5318 T5317 auxpass is,observed
R3584 T5319 T5320 advmod most,often
R3585 T5320 T5317 advmod often,observed
R3586 T5321 T5317 prep in,observed
R3587 T5322 T5323 amod multimeric,proteins
R3588 T5323 T5321 pobj proteins,in
R3589 T5324 T5323 prep with,proteins
R3590 T5325 T5326 amod multiple,domains
R3591 T5326 T5324 pobj domains,with
R3592 T5327 T5326 amod functional,domains
R3593 T5328 T5317 punct .,observed
R3594 T5330 T5331 advmod Unfortunately,remains
R3595 T5332 T5331 punct ", ",remains
R3596 T5333 T5334 det the,relationship
R3597 T5334 T5331 nsubj relationship,remains
R3598 T5335 T5336 compound structure,function
R3599 T5336 T5334 compound function,relationship
R3600 T5337 T5336 punct –,function
R3601 T5338 T5334 prep between,relationship
R3602 T5339 T5340 npadvmod disease,causing
R3603 T5340 T5342 amod causing,mutations
R3604 T5341 T5340 punct -,causing
R3605 T5342 T5338 pobj mutations,between
R3606 T5343 T5342 cc and,mutations
R3607 T5344 T5345 nmod XPD,domains
R3608 T5345 T5342 conj domains,mutations
R3609 T5346 T5345 amod functional,domains
R3610 T5347 T5334 punct ", ",relationship
R3611 T5348 T5334 prep including,relationship
R3612 T5349 T5350 amod detailed,information
R3613 T5350 T5348 pobj information,including
R3614 T5351 T5350 amod structural,information
R3615 T5352 T5350 prep on,information
R3616 T5353 T5352 pobj XPD,on
R3617 T5354 T5353 cc or,XPD
R3618 T5355 T5356 advmod even,stoichiometry
R3619 T5356 T5353 conj stoichiometry,XPD
R3620 T5357 T5356 poss its,stoichiometry
R3621 T5358 T5350 prep within,information
R3622 T5359 T5358 pobj TFIIH,within
R3623 T5360 T5331 punct ", ",remains
R3624 T5361 T5331 acomp unknown,remains
R3625 T5362 T5331 punct .,remains
R3626 T5364 T5365 advmod However,is
R3627 T5366 T5365 punct ", ",is
R3628 T5367 T5365 prep based,is
R3629 T5368 T5367 prep on,based
R3630 T5369 T5370 det the,ability
R3631 T5370 T5368 pobj ability,on
R3632 T5371 T5370 prep of,ability
R3633 T5372 T5373 compound cell,extracts
R3634 T5373 T5371 pobj extracts,of
R3635 T5374 T5375 dep that,are
R3636 T5375 T5373 relcl are,extracts
R3637 T5376 T5375 acomp defective,are
R3638 T5377 T5376 prep in,defective
R3639 T5378 T5379 nummod two,components
R3640 T5379 T5377 pobj components,in
R3641 T5380 T5379 amod different,components
R3642 T5381 T5379 compound TFIIH,components
R3643 T5382 T5379 punct (,components
R3644 T5383 T5379 appos XPD,components
R3645 T5384 T5383 cc and,XPD
R3646 T5385 T5383 conj XPB,XPD
R3647 T5386 T5370 punct ),ability
R3648 T5387 T5388 aux to,complement
R3649 T5388 T5370 acl complement,ability
R3650 T5389 T5390 compound NER,activity
R3651 T5390 T5388 dobj activity,complement
R3652 T5391 T5392 advmod in,vitro
R3653 T5392 T5388 advmod vitro,complement
R3654 T5393 T5394 punct [,26
R3655 T5394 T5370 parataxis 26,ability
R3656 T5395 T5394 punct ],26
R3657 T5396 T5365 punct ", ",is
R3658 T5397 T5365 nsubj it,is
R3659 T5398 T5365 acomp likely,is
R3660 T5399 T5400 mark that,multimerise
R3661 T5400 T5365 ccomp multimerise,is
R3662 T5401 T5400 nsubj TFIIH,multimerise
R3663 T5402 T5401 punct (,TFIIH
R3664 T5403 T5401 cc or,TFIIH
R3665 T5404 T5405 poss its,components
R3666 T5405 T5401 conj components,TFIIH
R3667 T5406 T5400 punct ),multimerise
R3668 T5407 T5400 aux can,multimerise
R3669 T5408 T5400 preconj either,multimerise
R3670 T5409 T5400 cc or,multimerise
R3671 T5410 T5400 conj exchange,multimerise
R3672 T5411 T5412 advmod at,least
R3673 T5412 T5413 advmod least,during
R3674 T5413 T5410 prep during,exchange
R3675 T5414 T5415 det the,reaction
R3676 T5415 T5413 pobj reaction,during
R3677 T5416 T5415 compound NER,reaction
R3678 T5417 T5365 punct .,is
R3679 T5419 T5420 advmod Furthermore,known
R3680 T5421 T5420 punct ", ",known
R3681 T5422 T5420 nsubjpass XPD,known
R3682 T5423 T5420 auxpass is,known
R3683 T5424 T5425 aux to,be
R3684 T5425 T5420 xcomp be,known
R3685 T5426 T5427 det a,subunit
R3686 T5427 T5425 attr subunit,be
R3687 T5428 T5427 advmod “,subunit
R3688 T5429 T5430 advmod loosely,bound
R3689 T5430 T5427 amod bound,subunit
R3690 T5431 T5427 punct ”,subunit
R3691 T5432 T5427 prep of,subunit
R3692 T5433 T5432 pobj TFIIH,of
R3693 T5434 T5435 punct [,27
R3694 T5435 T5420 parataxis 27,known
R3695 T5436 T5435 punct ],27
R3696 T5437 T5420 punct .,known
R3697 T5439 T5440 nsubj We,envisage
R3698 T5441 T5440 advmod thus,envisage
R3699 T5442 T5443 det the,mechanism
R3700 T5443 T5445 nsubj mechanism,involve
R3701 T5444 T5443 amod molecular,mechanism
R3702 T5445 T5440 ccomp involve,envisage
R3703 T5446 T5443 prep of,mechanism
R3704 T5447 T5448 amod interallelic,complementation
R3705 T5448 T5446 pobj complementation,of
R3706 T5449 T5445 aux to,involve
R3707 T5450 T5451 det the,exchange
R3708 T5451 T5445 dobj exchange,involve
R3709 T5452 T5451 prep of,exchange
R3710 T5453 T5454 compound XPD,molecules
R3711 T5454 T5452 pobj molecules,of
R3712 T5455 T5451 prep within,exchange
R3713 T5456 T5457 det the,complex
R3714 T5457 T5455 pobj complex,within
R3715 T5458 T5457 compound TFIIH,complex
R3716 T5459 T5451 cc or,exchange
R3717 T5460 T5451 conj turnover,exchange
R3718 T5461 T5460 prep of,turnover
R3719 T5462 T5463 compound TFIIH,complexes
R3720 T5463 T5461 pobj complexes,of
R3721 T5464 T5463 acl containing,complexes
R3722 T5465 T5466 amod different,molecules
R3723 T5466 T5464 dobj molecules,containing
R3724 T5467 T5466 compound XPD,molecules
R3725 T5468 T5460 prep at,turnover
R3726 T5469 T5470 det the,site
R3727 T5470 T5468 pobj site,at
R3728 T5471 T5470 prep of,site
R3729 T5472 T5473 compound DNA,damage
R3730 T5473 T5471 pobj damage,of
R3731 T5474 T5460 prep during,turnover
R3732 T5475 T5476 det the,course
R3733 T5476 T5474 pobj course,during
R3734 T5477 T5476 prep of,course
R3735 T5478 T5479 det the,genome
R3736 T5479 T5477 pobj genome,of
R3737 T5480 T5479 amod global,genome
R3738 T5481 T5482 advmod as,as
R3739 T5482 T5451 cc as,exchange
R3740 T5483 T5482 advmod well,as
R3741 T5484 T5485 npadvmod transcription,coupled
R3742 T5485 T5487 amod coupled,repair
R3743 T5486 T5485 punct -,coupled
R3744 T5487 T5451 conj repair,exchange
R3745 T5488 T5487 prep of,repair
R3746 T5489 T5490 preconj either,damage
R3747 T5490 T5488 pobj damage,of
R3748 T5491 T5492 npadvmod UV,induced
R3749 T5492 T5490 amod induced,damage
R3750 T5493 T5492 punct -,induced
R3751 T5494 T5492 cc or,induced
R3752 T5495 T5492 conj endogenous,induced
R3753 T5496 T5490 compound DNA,damage
R3754 T5497 T5440 punct .,envisage
R3755 T5607 T5608 det A,Paradigm
R3756 T5609 T5608 amod Biallelic,Paradigm
R3757 T5610 T5608 prep for,Paradigm
R3758 T5611 T5612 compound XPD,Disorders
R3759 T5612 T5610 pobj Disorders,for
R3760 T5614 T5615 advmod Recently,characterised
R3761 T5616 T5615 punct ", ",characterised
R3762 T5617 T5615 nsubjpass proteins,characterised
R3763 T5618 T5617 acl originating,proteins
R3764 T5619 T5618 prep from,originating
R3765 T5620 T5621 amod presumed,alleles
R3766 T5621 T5619 pobj alleles,from
R3767 T5622 T5621 amod null,alleles
R3768 T5623 T5615 auxpass were,characterised
R3769 T5624 T5615 advmod biochemically,characterised
R3770 T5625 T5615 prep as,characterised
R3771 T5626 T5625 amod inactive,as
R3772 T5627 T5615 prep in,characterised
R3773 T5628 T5629 amod basal,transcription
R3774 T5629 T5627 pobj transcription,in
R3775 T5630 T5631 punct [,27
R3776 T5631 T5615 parataxis 27,characterised
R3777 T5632 T5631 punct ],27
R3778 T5633 T5615 punct ", ",characterised
R3779 T5634 T5615 advcl providing,characterised
R3780 T5635 T5636 det an,explanation
R3781 T5636 T5634 dobj explanation,providing
R3782 T5637 T5636 prep as,explanation
R3783 T5638 T5637 prep to,as
R3784 T5639 T5640 advmod why,failed
R3785 T5640 T5638 pcomp failed,to
R3786 T5641 T5642 det these,alleles
R3787 T5642 T5640 nsubj alleles,failed
R3788 T5643 T5644 aux to,rescue
R3789 T5644 T5640 xcomp rescue,failed
R3790 T5645 T5644 dobj lethality,rescue
R3791 T5646 T5644 prep in,rescue
R3792 T5647 T5648 amod haploid,pombe
R3793 T5648 T5646 pobj pombe,in
R3794 T5649 T5648 nmod S.,pombe
R3795 T5650 T5648 prep with,pombe
R3796 T5651 T5652 det a,mutation
R3797 T5652 T5650 pobj mutation,with
R3798 T5653 T5652 amod null,mutation
R3799 T5654 T5652 prep in,mutation
R3800 T5655 T5656 det the,homologue
R3801 T5656 T5654 pobj homologue,in
R3802 T5657 T5656 compound XPD,homologue
R3803 T5658 T5656 appos rad15,homologue
R3804 T5659 T5660 punct [,19
R3805 T5660 T5640 parataxis 19,failed
R3806 T5661 T5660 punct ],19
R3807 T5662 T5615 punct .,characterised
R3808 T5664 T5665 poss Our,data
R3809 T5665 T5666 nsubj data,suggest
R3810 T5667 T5668 mark that,have
R3811 T5668 T5666 ccomp have,suggest
R3812 T5669 T5670 amod certain,alleles
R3813 T5670 T5668 nsubj alleles,have
R3814 T5671 T5672 advmod presumed,null
R3815 T5672 T5670 amod null,alleles
R3816 T5673 T5668 punct ", ",have
R3817 T5674 T5675 mark although,unable
R3818 T5675 T5668 advcl unable,have
R3819 T5676 T5677 prep on,support
R3820 T5677 T5675 xcomp support,unable
R3821 T5678 T5679 poss their,own
R3822 T5679 T5676 pobj own,on
R3823 T5680 T5677 aux to,support
R3824 T5681 T5682 amod basal,transcription
R3825 T5682 T5677 dobj transcription,support
R3826 T5683 T5668 punct ", ",have
R3827 T5684 T5668 aux may,have
R3828 T5685 T5668 prep in,have
R3829 T5686 T5685 pobj fact,in
R3830 T5687 T5688 det a,impact
R3831 T5688 T5668 dobj impact,have
R3832 T5689 T5688 amod substantial,impact
R3833 T5690 T5688 prep on,impact
R3834 T5691 T5692 compound disease,outcome
R3835 T5692 T5690 pobj outcome,on
R3836 T5693 T5688 prep in,impact
R3837 T5694 T5695 nmod compound,humans
R3838 T5695 T5693 pobj humans,in
R3839 T5696 T5695 amod heterozygous,humans
R3840 T5697 T5668 punct ", ",have
R3841 T5698 T5699 mark as,in
R3842 T5699 T5668 advcl in,have
R3843 T5700 T5699 nsubj they,in
R3844 T5701 T5699 aux do,in
R3845 T5702 T5703 compound mouse,models
R3846 T5703 T5699 pobj models,in
R3847 T5704 T5666 punct .,suggest
R3848 T5706 T5707 amod Clinical,evidence
R3849 T5707 T5708 nsubj evidence,comes
R3850 T5709 T5707 prep in,evidence
R3851 T5710 T5709 pobj support,in
R3852 T5711 T5710 prep of,support
R3853 T5712 T5713 det this,hypothesis
R3854 T5713 T5711 pobj hypothesis,of
R3855 T5714 T5708 prep from,comes
R3856 T5715 T5716 det a,number
R3857 T5716 T5714 pobj number,from
R3858 T5717 T5716 prep of,number
R3859 T5718 T5719 compound XP,patients
R3860 T5719 T5717 pobj patients,of
R3861 T5720 T5719 compound complementation,patients
R3862 T5721 T5722 compound group,D
R3863 T5722 T5719 compound D,patients
R3864 T5723 T5724 dep that,fit
R3865 T5724 T5719 relcl fit,patients
R3866 T5725 T5724 aux do,fit
R3867 T5726 T5724 neg not,fit
R3868 T5727 T5724 prep within,fit
R3869 T5728 T5729 det the,framework
R3870 T5729 T5727 pobj framework,within
R3871 T5730 T5729 prep of,framework
R3872 T5731 T5732 det the,paradigm
R3873 T5732 T5730 pobj paradigm,of
R3874 T5733 T5732 amod current,paradigm
R3875 T5734 T5732 amod monoallelic,paradigm
R3876 T5735 T5732 prep of,paradigm
R3877 T5736 T5737 compound XPD,disorders
R3878 T5737 T5735 pobj disorders,of
R3879 T5738 T5739 punct (,Figure
R3880 T5739 T5708 parataxis Figure,comes
R3881 T5740 T5739 nummod 5,Figure
R3882 T5741 T5739 punct ),Figure
R3883 T5742 T5708 punct .,comes
R3884 T5744 T5745 prep In,had
R3885 T5746 T5744 pobj contrast,In
R3886 T5747 T5746 prep to,contrast
R3887 T5748 T5749 nummod two,patients
R3888 T5749 T5747 pobj patients,to
R3889 T5750 T5749 amod hemizygous,patients
R3890 T5751 T5749 compound XPDXPCS,patients
R3891 T5752 T5749 acl carrying,patients
R3892 T5753 T5754 det the,alleles
R3893 T5754 T5752 dobj alleles,carrying
R3894 T5755 T5756 npadvmod XPDG47R,encoding
R3895 T5756 T5754 amod encoding,alleles
R3896 T5757 T5755 punct -,XPDG47R
R3897 T5758 T5755 cc or,XPDG47R
R3898 T5759 T5755 conj XPDR666W,XPDG47R
R3899 T5760 T5756 punct -,encoding
R3900 T5761 T5762 dep who,died
R3901 T5762 T5754 relcl died,alleles
R3902 T5763 T5762 prep of,died
R3903 T5764 T5765 det the,disease
R3904 T5765 T5763 pobj disease,of
R3905 T5766 T5762 prep before,died
R3906 T5767 T5768 nummod 2,y
R3907 T5768 T5766 pobj y,before
R3908 T5769 T5768 prep of,y
R3909 T5770 T5769 pobj age,of
R3910 T5771 T5745 punct ", ",had
R3911 T5772 T5773 nummod two,patients
R3912 T5773 T5745 nsubj patients,had
R3913 T5774 T5773 amod compound,patients
R3914 T5775 T5773 amod heterozygous,patients
R3915 T5776 T5773 compound XPDXPCS,patients
R3916 T5777 T5773 acl carrying,patients
R3917 T5778 T5779 det the,alleles
R3918 T5779 T5777 dobj alleles,carrying
R3919 T5780 T5779 amod same,alleles
R3920 T5781 T5782 npadvmod XPDG47R,encoding
R3921 T5782 T5779 amod encoding,alleles
R3922 T5783 T5781 punct -,XPDG47R
R3923 T5784 T5781 cc or,XPDG47R
R3924 T5785 T5781 conj XPDR666W,XPDG47R
R3925 T5786 T5782 punct -,encoding
R3926 T5787 T5779 prep in,alleles
R3927 T5788 T5787 pobj addition,in
R3928 T5789 T5788 prep to,addition
R3929 T5790 T5791 det the,730
R3930 T5791 T5789 pobj 730,to
R3931 T5792 T5793 advmod presumed,null
R3932 T5793 T5791 amod null,730
R3933 T5794 T5791 nmod XPDL461V,730
R3934 T5795 T5791 punct +,730
R3935 T5796 T5791 compound del716,730
R3936 T5797 T5791 punct −,730
R3937 T5798 T5773 appos both,patients
R3938 T5799 T5800 advmod considerably,milder
R3939 T5800 T5801 amod milder,symptoms
R3940 T5801 T5745 dobj symptoms,had
R3941 T5802 T5801 compound disease,symptoms
R3942 T5803 T5745 cc and,had
R3943 T5804 T5745 conj survived,had
R3944 T5805 T5806 amod more,ten
R3945 T5806 T5808 nummod ten,times
R3946 T5807 T5806 quantmod than,ten
R3947 T5808 T5809 npadvmod times,longer
R3948 T5809 T5804 advmod longer,survived
R3949 T5810 T5811 punct (,A.
R3950 T5811 T5804 meta A.,survived
R3951 T5812 T5811 nmod Lehmann,A.
R3952 T5813 T5811 punct ", ",A.
R3953 T5814 T5811 amod personal,A.
R3954 T5815 T5811 nmod communication,A.
R3955 T5816 T5811 punct ),A.
R3956 T5817 T5818 punct (,Figure
R3957 T5818 T5804 parataxis Figure,survived
R3958 T5819 T5818 nummod 5,Figure
R3959 T5820 T5818 punct ),Figure
R3960 T5821 T5745 punct .,had
R3961 T5823 T5824 compound Compound,heterozygosity
R3962 T5824 T5825 nsubjpass heterozygosity,associated
R3963 T5826 T5825 auxpass is,associated
R3964 T5827 T5825 advmod also,associated
R3965 T5828 T5825 prep with,associated
R3966 T5829 T5830 det the,syndrome
R3967 T5830 T5828 pobj syndrome,with
R3968 T5831 T5832 advmod recently,reported
R3969 T5832 T5830 amod reported,syndrome
R3970 T5833 T5830 nmod combination,syndrome
R3971 T5834 T5830 nmod XP,syndrome
R3972 T5835 T5834 cc and,XP
R3973 T5836 T5834 conj TTD,XP
R3974 T5837 T5838 punct (,XPTTD
R3975 T5838 T5836 parataxis XPTTD,TTD
R3976 T5839 T5838 punct ),XPTTD
R3977 T5840 T5841 punct [,8
R3978 T5841 T5825 parataxis 8,associated
R3979 T5842 T5841 punct ],8
R3980 T5843 T5825 punct .,associated
R3981 T5845 T5846 advcl Similar,had
R3982 T5847 T5845 prep to,Similar
R3983 T5848 T5849 det the,mice
R3984 T5849 T5847 pobj mice,to
R3985 T5850 T5851 nmod XpdTTD,†XPCS
R3986 T5851 T5849 nmod †XPCS,mice
R3987 T5852 T5851 punct /,†XPCS
R3988 T5853 T5851 cc and,†XPCS
R3989 T5854 T5855 compound XpdTTD,†XP
R3990 T5855 T5851 conj †XP,†XPCS
R3991 T5856 T5855 punct /,†XP
R3992 T5857 T5849 acl described,mice
R3993 T5858 T5857 advmod here,described
R3994 T5859 T5846 punct ", ",had
R3995 T5860 T5861 det both,patients
R3996 T5861 T5846 nsubj patients,had
R3997 T5862 T5861 prep with,patients
R3998 T5863 T5862 pobj XPTTD,with
R3999 T5864 T5861 acl described,patients
R4000 T5865 T5866 advmod so,far
R4001 T5866 T5864 advmod far,described
R4002 T5867 T5868 amod intermediate,values
R4003 T5868 T5846 dobj values,had
R4004 T5869 T5870 compound hair,cysteine
R4005 T5870 T5868 compound cysteine,values
R4006 T5871 T5846 punct .,had
R4007 T5873 T5874 advmod Furthermore,carried
R4008 T5875 T5874 punct ", ",carried
R4009 T5876 T5877 compound XPTTD,XP38BR
R4010 T5877 T5874 nsubj XP38BR,carried
R4011 T5878 T5877 compound patient,XP38BR
R4012 T5879 T5880 det a,mutation
R4013 T5880 T5874 dobj mutation,carried
R4014 T5881 T5880 punct “,mutation
R4015 T5882 T5880 amod causative,mutation
R4016 T5883 T5880 punct ”,mutation
R4017 T5884 T5880 compound TTD,mutation
R4018 T5885 T5874 prep in,carried
R4019 T5886 T5887 nummod one,allele
R4020 T5887 T5885 pobj allele,in
R4021 T5888 T5874 cc and,carried
R4022 T5889 T5890 det a,mutation
R4023 T5890 T5874 conj mutation,carried
R4024 T5891 T5890 amod novel,mutation
R4025 T5892 T5890 compound point,mutation
R4026 T5893 T5890 acl encoding,mutation
R4027 T5894 T5893 dobj XPDL485P,encoding
R4028 T5895 T5890 prep in,mutation
R4029 T5896 T5897 det the,other
R4030 T5897 T5895 pobj other,in
R4031 T5898 T5874 punct .,carried
R4032 T5900 T5901 mark Although,fails
R4033 T5901 T5907 advcl fails,suggest
R4034 T5902 T5903 det the,allele
R4035 T5903 T5901 nsubj allele,fails
R4036 T5904 T5905 npadvmod XPDL485P,encoding
R4037 T5905 T5903 amod encoding,allele
R4038 T5906 T5905 punct -,encoding
R4039 T5908 T5909 aux to,complement
R4040 T5909 T5901 xcomp complement,fails
R4041 T5910 T5909 dobj viability,complement
R4042 T5911 T5909 prep in,complement
R4043 T5912 T5913 det the,strain
R4044 T5913 T5911 pobj strain,in
R4045 T5914 T5913 amod haploid,strain
R4046 T5915 T5913 nmod S.,strain
R4047 T5916 T5913 nmod pombe,strain
R4048 T5917 T5913 compound rad15,strain
R4049 T5918 T5913 compound deletion,strain
R4050 T5919 T5901 cc and,fails
R4051 T5920 T5901 conj is,fails
R4052 T5921 T5920 advmod thus,is
R4053 T5922 T5920 acomp interpretable,is
R4054 T5923 T5922 prep as,interpretable
R4055 T5924 T5925 det a,allele
R4056 T5925 T5923 pobj allele,as
R4057 T5926 T5925 amod null,allele
R4058 T5927 T5928 punct [,8
R4059 T5928 T5920 parataxis 8,is
R4060 T5929 T5928 punct ],8
R4061 T5930 T5907 punct ", ",suggest
R4062 T5931 T5907 nsubj we,suggest
R4063 T5932 T5907 advmod nonetheless,suggest
R4064 T5933 T5934 mark that,involves
R4065 T5934 T5907 ccomp involves,suggest
R4066 T5935 T5936 det the,phenotype
R4067 T5936 T5934 nsubj phenotype,involves
R4068 T5937 T5936 amod combined,phenotype
R4069 T5938 T5936 compound XPTTD,phenotype
R4070 T5939 T5936 prep in,phenotype
R4071 T5940 T5941 det this,patient
R4072 T5941 T5939 pobj patient,in
R4073 T5942 T5943 amod phenotypic,contributions
R4074 T5943 T5934 dobj contributions,involves
R4075 T5944 T5943 prep from,contributions
R4076 T5945 T5946 det both,alleles
R4077 T5946 T5944 pobj alleles,from
R4078 T5947 T5907 punct .,suggest
R4079 T5949 T5950 advcl Taken,suggest
R4080 T5951 T5949 advmod together,Taken
R4081 T5952 T5950 punct ", ",suggest
R4082 T5953 T5954 det these,data
R4083 T5954 T5950 nsubj data,suggest
R4084 T5955 T5956 det a,shift
R4085 T5956 T5950 dobj shift,suggest
R4086 T5957 T5956 prep to,shift
R4087 T5958 T5959 det a,paradigm
R4088 T5959 T5957 pobj paradigm,to
R4089 T5960 T5959 amod biallelic,paradigm
R4090 T5961 T5959 prep for,paradigm
R4091 T5962 T5963 nmod compound,patients
R4092 T5963 T5961 pobj patients,for
R4093 T5964 T5963 amod heterozygous,patients
R4094 T5965 T5963 prep in,patients
R4095 T5966 T5967 compound XP,D
R4096 T5967 T5965 pobj D,in
R4097 T5968 T5967 compound complementation,D
R4098 T5969 T5967 compound group,D
R4099 T5970 T5950 punct .,suggest
R4100 T6042 T6041 prep of,Potential
R4101 T6043 T6044 amod Combined,Alleles
R4102 T6044 T6042 pobj Alleles,of
R4103 T6045 T6044 amod Recessive,Alleles
R4104 T6046 T6047 aux to,Affect
R4105 T6047 T6041 acl Affect,Potential
R4106 T6048 T6049 amod Phenotypic,Diversity
R4107 T6049 T6047 dobj Diversity,Affect
R4108 T6050 T6047 prep in,Affect
R4109 T6051 T6050 pobj Mammals,in
R4110 T6053 T6054 prep In,remains
R4111 T6055 T6053 pobj humans,In
R4112 T6056 T6054 punct ", ",remains
R4113 T6057 T6058 det the,relevance
R4114 T6058 T6054 nsubj relevance,remains
R4115 T6059 T6058 amod clinical,relevance
R4116 T6060 T6058 prep of,relevance
R4117 T6061 T6062 amod biallelic,effects
R4118 T6062 T6060 pobj effects,of
R4119 T6063 T6064 amod such,as
R4120 T6064 T6062 prep as,effects
R4121 T6065 T6066 amod interallelic,complementation
R4122 T6066 T6064 pobj complementation,as
R4123 T6067 T6054 acomp unknown,remains
R4124 T6068 T6054 punct .,remains
R4125 T6070 T6071 mark Although,described
R4126 T6071 T6081 advcl described,noted
R4127 T6072 T6073 amod interallelic,complementation
R4128 T6073 T6071 nsubjpass complementation,described
R4129 T6074 T6073 prep between,complementation
R4130 T6075 T6076 nummod two,alleles
R4131 T6076 T6074 pobj alleles,between
R4132 T6077 T6076 amod endogenous,alleles
R4133 T6078 T6076 amod mutant,alleles
R4134 T6079 T6071 aux has,described
R4135 T6080 T6071 auxpass been,described
R4136 T6082 T6071 prep in,described
R4137 T6083 T6082 pobj cells,in
R4138 T6084 T6083 prep from,cells
R4139 T6085 T6086 det a,patient
R4140 T6086 T6084 pobj patient,from
R4141 T6087 T6086 nmod compound,patient
R4142 T6088 T6086 amod heterozygous,patient
R4143 T6089 T6086 prep with,patient
R4144 T6090 T6091 amod methylmalonic,acidaemia
R4145 T6091 T6089 pobj acidaemia,with
R4146 T6092 T6081 punct ", ",noted
R4147 T6093 T6094 det no,effects
R4148 T6094 T6081 nsubjpass effects,noted
R4149 T6095 T6094 amod observable,effects
R4150 T6096 T6094 prep on,effects
R4151 T6097 T6098 compound disease,outcome
R4152 T6098 T6096 pobj outcome,on
R4153 T6099 T6081 auxpass were,noted
R4154 T6100 T6081 prep in,noted
R4155 T6101 T6102 det the,patient
R4156 T6102 T6100 pobj patient,in
R4157 T6103 T6104 punct [,28
R4158 T6104 T6081 parataxis 28,noted
R4159 T6105 T6104 punct ],28
R4160 T6106 T6081 punct .,noted
R4161 T6108 T6109 advmod Thus,is
R4162 T6110 T6109 punct ", ",is
R4163 T6111 T6109 prep to,is
R4164 T6112 T6113 det the,best
R4165 T6113 T6111 pobj best,to
R4166 T6114 T6113 prep of,best
R4167 T6115 T6116 poss our,knowledge
R4168 T6116 T6114 pobj knowledge,of
R4169 T6117 T6109 punct ", ",is
R4170 T6118 T6119 det the,amelioration
R4171 T6119 T6109 nsubj amelioration,is
R4172 T6120 T6119 prep of,amelioration
R4173 T6121 T6122 amod progeroid,features
R4174 T6122 T6120 pobj features,of
R4175 T6123 T6119 acl observed,amelioration
R4176 T6124 T6123 advmod here,observed
R4177 T6125 T6126 det the,demonstration
R4178 T6126 T6109 attr demonstration,is
R4179 T6127 T6126 amod first,demonstration
R4180 T6128 T6129 advmod in,vivo
R4181 T6129 T6126 amod vivo,demonstration
R4182 T6130 T6126 prep in,demonstration
R4183 T6131 T6132 nmod compound,animals
R4184 T6132 T6130 pobj animals,in
R4185 T6133 T6132 amod heterozygous,animals
R4186 T6134 T6132 prep of,animals
R4187 T6135 T6136 amod interallelic,complementation
R4188 T6136 T6134 pobj complementation,of
R4189 T6137 T6126 amod relevant,demonstration
R4190 T6138 T6137 prep to,relevant
R4191 T6139 T6140 det a,disease
R4192 T6140 T6138 pobj disease,to
R4193 T6141 T6140 amod human,disease
R4194 T6142 T6109 punct .,is
R4195 T6144 T6145 advcl Keeping,is
R4196 T6146 T6144 prep in,Keeping
R4197 T6147 T6146 pobj mind,in
R4198 T6148 T6149 mark that,result
R4199 T6149 T6144 ccomp result,Keeping
R4200 T6150 T6151 det the,alleles
R4201 T6151 T6149 nsubj alleles,result
R4202 T6152 T6153 punct ~,"1,200"
R4203 T6153 T6151 nummod "1,200",alleles
R4204 T6154 T6151 acl known,alleles
R4205 T6155 T6156 aux to,exist
R4206 T6156 T6154 xcomp exist,known
R4207 T6157 T6156 prep for,exist
R4208 T6158 T6159 det the,gene
R4209 T6159 T6157 pobj gene,for
R4210 T6160 T6159 compound CTRF,gene
R4211 T6161 T6159 acl implicated,gene
R4212 T6162 T6161 prep in,implicated
R4213 T6163 T6164 det the,disorder
R4214 T6164 T6162 pobj disorder,in
R4215 T6165 T6164 amod common,disorder
R4216 T6166 T6164 amod autosomal,disorder
R4217 T6167 T6164 amod recessive,disorder
R4218 T6168 T6169 amod cystic,fibrosis
R4219 T6169 T6164 appos fibrosis,disorder
R4220 T6170 T6161 advmod alone,implicated
R4221 T6171 T6172 punct [,29
R4222 T6172 T6154 parataxis 29,known
R4223 T6173 T6172 punct ],29
R4224 T6174 T6149 aux can,result
R4225 T6175 T6149 advmod theoretically,result
R4226 T6176 T6149 prep in,result
R4227 T6177 T6178 punct ~,"700,000"
R4228 T6178 T6179 nummod "700,000",combinations
R4229 T6179 T6176 pobj combinations,in
R4230 T6180 T6179 amod different,combinations
R4231 T6181 T6179 amod allelic,combinations
R4232 T6182 T6145 punct ", ",is
R4233 T6183 T6184 det the,number
R4234 T6184 T6145 nsubj number,is
R4235 T6185 T6184 amod potential,number
R4236 T6186 T6184 prep of,number
R4237 T6187 T6188 amod allelic,combinations
R4238 T6188 T6186 pobj combinations,of
R4239 T6189 T6188 prep of,combinations
R4240 T6190 T6191 amod different,mutations
R4241 T6191 T6189 pobj mutations,of
R4242 T6192 T6191 amod recessive,mutations
R4243 T6193 T6191 cc and,mutations
R4244 T6194 T6195 amod single,polymorphisms
R4245 T6195 T6191 conj polymorphisms,mutations
R4246 T6196 T6195 compound nucleotide,polymorphisms
R4247 T6197 T6198 npadvmod genome,wide
R4248 T6198 T6184 amod wide,number
R4249 T6199 T6198 punct -,wide
R4250 T6200 T6145 advmod currently,is
R4251 T6201 T6145 acomp incalculable,is
R4252 T6202 T6145 punct .,is
R4253 T6204 T6205 nsubj We,suggest
R4254 T6206 T6207 amod biallelic,effects
R4255 T6207 T6205 dobj effects,suggest
R4256 T6208 T6205 prep as,suggest
R4257 T6209 T6210 det a,variable
R4258 T6210 T6208 pobj variable,as
R4259 T6211 T6212 advmod previously,underestimated
R4260 T6212 T6213 amod underestimated,important
R4261 T6213 T6210 amod important,variable
R4262 T6214 T6213 advmod yet,important
R4263 T6215 T6205 prep in,suggest
R4264 T6216 T6215 pcomp considering,in
R4265 T6217 T6218 compound genotype,phenotype
R4266 T6218 T6220 compound phenotype,relationships
R4267 T6219 T6218 punct –,phenotype
R4268 T6220 T6216 dobj relationships,considering
R4269 T6221 T6216 prep from,considering
R4270 T6222 T6223 amod autosomal,disease
R4271 T6223 T6221 pobj disease,from
R4272 T6224 T6223 amod recessive,disease
R4273 T6225 T6221 prep to,from
R4274 T6226 T6227 amod normal,diversity
R4275 T6227 T6225 pobj diversity,to
R4276 T6228 T6227 amod phenotypic,diversity
R4277 T6229 T6216 prep in,considering
R4278 T6230 T6229 pobj mammals,in
R4279 T6231 T6205 punct .,suggest
R4280 T6233 T6234 nsubj Extension,implies
R4281 T6235 T6233 prep of,Extension
R4282 T6236 T6237 det the,concept
R4283 T6237 T6235 pobj concept,of
R4284 T6238 T6237 amod above,concept
R4285 T6239 T6240 mark that,enter
R4286 T6240 T6234 ccomp enter,implies
R4287 T6241 T6242 amod recessive,mutations
R4288 T6242 T6240 nsubj mutations,enter
R4289 T6243 T6240 aux can,enter
R4290 T6244 T6245 amod evolutionary,selection
R4291 T6245 T6240 dobj selection,enter
R4292 T6246 T6240 prep in,enter
R4293 T6247 T6246 pobj F1,in
R4294 T6248 T6240 prep provided,enter
R4295 T6249 T6250 mark that,carries
R4296 T6250 T6248 pcomp carries,provided
R4297 T6251 T6252 det the,allele
R4298 T6252 T6250 nsubj allele,carries
R4299 T6253 T6252 amod second,allele
R4300 T6254 T6255 det a,alteration
R4301 T6255 T6250 dobj alteration,carries
R4302 T6256 T6255 amod different,alteration
R4303 T6257 T6255 amod recessive,alteration
R4304 T6258 T6234 punct .,implies
R4305 T6260 T6261 advmod Finally,highlight
R4306 T6262 T6261 punct ", ",highlight
R4307 T6263 T6264 poss our,data
R4308 T6264 T6261 nsubj data,highlight
R4309 T6265 T6266 det the,potential
R4310 T6266 T6261 dobj potential,highlight
R4311 T6267 T6266 prep of,potential
R4312 T6268 T6269 advmod clinically,relevant
R4313 T6269 T6270 amod relevant,alleles
R4314 T6270 T6267 pobj alleles,of
R4315 T6271 T6272 advmod previously,designated
R4316 T6272 T6270 acl designated,alleles
R4317 T6273 T6272 prep as,designated
R4318 T6274 T6273 amod null,as
R4319 T6275 T6270 punct ", ",alleles
R4320 T6276 T6270 prep with,alleles
R4321 T6277 T6278 amod little,expression
R4322 T6278 T6276 pobj expression,with
R4323 T6279 T6277 cc or,little
R4324 T6280 T6277 conj no,little
R4325 T6281 T6278 amod detectable,expression
R4326 T6282 T6278 cc or,expression
R4327 T6283 T6278 conj activity,expression
R4328 T6284 T6266 punct ", ",potential
R4329 T6285 T6286 aux to,contribute
R4330 T6286 T6266 acl contribute,potential
R4331 T6287 T6286 advmod nonetheless,contribute
R4332 T6288 T6286 prep to,contribute
R4333 T6289 T6288 pobj phenotype,to
R4334 T6290 T6261 punct .,highlight
R4335 T6365 T6364 cc and,Derivation
R4336 T6366 T6364 conj analysis,Derivation
R4337 T6367 T6364 prep of,Derivation
R4338 T6368 T6369 amod mutant,mice
R4339 T6369 T6367 pobj mice,of
R4340 T6370 T6364 punct .,Derivation
R4341 T6372 T6373 nsubjpass Generation,described
R4342 T6374 T6372 prep of,Generation
R4343 T6375 T6376 nmod XpdTTD,mice
R4344 T6376 T6374 pobj mice,of
R4345 T6377 T6378 punct (,XPDR722W
R4346 T6378 T6375 parataxis XPDR722W,XpdTTD
R4347 T6379 T6378 punct ),XPDR722W
R4348 T6380 T6375 cc and,XpdTTD
R4349 T6381 T6382 compound XpdTTD,KO
R4350 T6382 T6375 conj KO,XpdTTD
R4351 T6383 T6382 punct /,KO
R4352 T6384 T6373 aux has,described
R4353 T6385 T6373 auxpass been,described
R4354 T6386 T6373 advmod previously,described
R4355 T6387 T6388 punct [,22
R4356 T6388 T6373 parataxis 22,described
R4357 T6389 T6388 nummod 21,22
R4358 T6390 T6388 punct ",",22
R4359 T6391 T6388 punct ],22
R4360 T6392 T6373 punct .,described
R4361 T6394 T6395 det A,description
R4362 T6395 T6397 nsubjpass description,provided
R4363 T6396 T6395 amod detailed,description
R4364 T6398 T6395 prep of,description
R4365 T6399 T6400 det the,generation
R4366 T6400 T6398 pobj generation,of
R4367 T6401 T6400 prep of,generation
R4368 T6402 T6403 amod targeting,constructs
R4369 T6403 T6401 pobj constructs,of
R4370 T6404 T6403 prep for,constructs
R4371 T6405 T6406 nmod Xpd†XPCS,alleles
R4372 T6406 T6404 pobj alleles,for
R4373 T6407 T6405 cc and,Xpd†XPCS
R4374 T6408 T6405 conj Xpd †XP,Xpd†XPCS
R4375 T6409 T6406 acl carrying,alleles
R4376 T6410 T6409 dobj mutations,carrying
R4377 T6411 T6410 acl encoding,mutations
R4378 T6412 T6413 det the,alterations
R4379 T6413 T6411 dobj alterations,encoding
R4380 T6414 T6413 nmod G602D,alterations
R4381 T6415 T6414 cc and,G602D
R4382 T6416 T6414 conj R683W,G602D
R4383 T6417 T6397 aux will,provided
R4384 T6418 T6397 auxpass be,provided
R4385 T6419 T6397 prep upon,provided
R4386 T6420 T6419 pobj request,upon
R4387 T6421 T6397 punct .,provided
R4388 T6423 T6424 amod Chimeric,fibroblasts
R4389 T6424 T6429 nsubjpass fibroblasts,generated
R4390 T6425 T6424 nmod mice,fibroblasts
R4391 T6426 T6425 cc and,mice
R4392 T6427 T6428 npadvmod mouse,embryonic
R4393 T6428 T6425 conj embryonic,mice
R4394 T6430 T6429 auxpass were,generated
R4395 T6431 T6429 prep according,generated
R4396 T6432 T6431 prep to,according
R4397 T6433 T6434 amod standard,procedures
R4398 T6434 T6432 pobj procedures,to
R4399 T6435 T6429 punct .,generated
R4400 T6437 T6438 nmod Haematoxylin,staining
R4401 T6438 T6441 nsubjpass staining,performed
R4402 T6439 T6437 cc and,Haematoxylin
R4403 T6440 T6437 conj eosin,Haematoxylin
R4404 T6442 T6441 auxpass was,performed
R4405 T6443 T6441 prep according,performed
R4406 T6444 T6443 prep to,according
R4407 T6445 T6446 amod standard,procedures
R4408 T6446 T6444 pobj procedures,to
R4409 T6447 T6441 punct .,performed
R4410 T6449 T6450 compound Amino,acid
R4411 T6450 T6451 compound acid,analysis
R4412 T6451 T6452 nsubjpass analysis,conducted
R4413 T6453 T6452 auxpass was,conducted
R4414 T6454 T6455 mark as,described
R4415 T6455 T6452 advcl described,conducted
R4416 T6456 T6455 prep in,described
R4417 T6457 T6456 punct [,in
R4418 T6458 T6456 pobj 21,in
R4419 T6459 T6452 punct ],conducted
R4420 T6460 T6452 punct .,conducted
R4421 T6462 T6463 compound Blood,values
R4422 T6463 T6464 nsubjpass values,analysed
R4423 T6465 T6464 auxpass were,analysed
R4424 T6466 T6464 advcl using,analysed
R4425 T6467 T6468 nmod Animal,Vet
R4426 T6468 T6466 dobj Vet,using
R4427 T6469 T6468 nmod Blood,Vet
R4428 T6470 T6468 amod Counter,Vet
R4429 T6471 T6472 punct (,Diagnostix
R4430 T6472 T6468 parataxis Diagnostix,Vet
R4431 T6473 T6472 compound ABX,Diagnostix
R4432 T6474 T6472 punct ", ",Diagnostix
R4433 T6475 T6472 npadvmod Montpellier,Diagnostix
R4434 T6476 T6472 punct ", ",Diagnostix
R4435 T6477 T6472 npadvmod France,Diagnostix
R4436 T6478 T6472 punct ),Diagnostix
R4437 T6479 T6464 punct .,analysed
R4438 T6481 T6482 nsubjpass Radiographs,taken
R4439 T6483 T6482 auxpass were,taken
R4440 T6484 T6482 punct ", ",taken
R4441 T6485 T6482 cc and,taken
R4442 T6486 T6487 amod relative,density
R4443 T6487 T6490 nsubjpass density,calculated
R4444 T6488 T6489 compound bone,mineral
R4445 T6489 T6487 compound mineral,density
R4446 T6490 T6482 conj calculated,taken
R4447 T6491 T6490 auxpass was,calculated
R4448 T6492 T6493 mark as,described
R4449 T6493 T6490 advcl described,calculated
R4450 T6494 T6493 prep in,described
R4451 T6495 T6494 punct [,in
R4452 T6496 T6494 pobj 15,in
R4453 T6497 T6490 punct ],calculated
R4454 T6498 T6490 punct .,calculated
R4455 T6500 T6501 nsubj Mice,were
R4456 T6502 T6500 acl used,Mice
R4457 T6503 T6502 prep in,used
R4458 T6504 T6505 det this,study
R4459 T6505 T6503 pobj study,in
R4460 T6506 T6501 prep in,were
R4461 T6507 T6508 det a,background
R4462 T6508 T6506 pobj background,in
R4463 T6509 T6510 nmod 129Ola,C57BL6
R4464 T6510 T6508 nmod C57BL6,background
R4465 T6511 T6510 punct /,C57BL6
R4466 T6512 T6508 amod mixed,background
R4467 T6513 T6514 mark unless,noted
R4468 T6514 T6501 advcl noted,were
R4469 T6515 T6514 advmod differently,noted
R4470 T6516 T6501 punct .,were
R4471 T6518 T6519 det All,experiments
R4472 T6519 T6520 nsubjpass experiments,judged
R4473 T6521 T6519 acl involving,experiments
R4474 T6522 T6521 dobj mice,involving
R4475 T6523 T6520 auxpass were,judged
R4476 T6524 T6520 cc and,judged
R4477 T6525 T6520 conj approved,judged
R4478 T6526 T6525 agent by,approved
R4479 T6527 T6528 det the,committee
R4480 T6528 T6526 pobj committee,by
R4481 T6529 T6528 amod national,committee
R4482 T6530 T6528 prep for,committee
R4483 T6531 T6532 amod genetic,identification
R4484 T6532 T6530 pobj identification,for
R4485 T6533 T6532 prep of,identification
R4486 T6534 T6533 pobj organisms,of
R4487 T6535 T6528 cc and,committee
R4488 T6536 T6537 det the,committee
R4489 T6537 T6528 conj committee,committee
R4490 T6538 T6537 nmod animal,committee
R4491 T6539 T6537 amod ethical,committee
R4492 T6540 T6520 punct ", ",judged
R4493 T6541 T6520 cc and,judged
R4494 T6542 T6543 auxpass were,conducted
R4495 T6543 T6520 conj conducted,judged
R4496 T6544 T6543 prep according,conducted
R4497 T6545 T6544 prep to,according
R4498 T6546 T6547 amod national,guidelines
R4499 T6547 T6545 pobj guidelines,to
R4500 T6548 T6546 cc and,national
R4501 T6549 T6546 conj international,national
R4502 T6550 T6520 punct .,judged
R4503 T6587 T6588 compound UV,sensitivity
R4504 T6589 T6588 punct ", ",sensitivity
R4505 T6590 T6591 nmod UV,UDS
R4506 T6591 T6593 nmod UDS,activity
R4507 T6592 T6591 punct -,UDS
R4508 T6593 T6588 appos activity,sensitivity
R4509 T6594 T6591 punct ", ",UDS
R4510 T6595 T6596 compound UV,RRS
R4511 T6596 T6591 conj RRS,UDS
R4512 T6597 T6596 punct -,RRS
R4513 T6598 T6596 punct ", ",RRS
R4514 T6599 T6596 cc and,RRS
R4515 T6600 T6596 conj TFIIH,RRS
R4516 T6601 T6602 compound incision,excision
R4517 T6602 T6593 compound excision,activity
R4518 T6603 T6602 punct /,excision
R4519 T6604 T6588 punct .,sensitivity
R4520 T6606 T6607 nmod UV,survival
R4521 T6607 T6608 nmod survival,assays
R4522 T6608 T6618 nsubjpass assays,performed
R4523 T6609 T6607 punct ", ",survival
R4524 T6610 T6611 compound UV,UDS
R4525 T6611 T6607 conj UDS,survival
R4526 T6612 T6611 punct -,UDS
R4527 T6613 T6611 punct ", ",UDS
R4528 T6614 T6611 cc and,UDS
R4529 T6615 T6616 compound UV,RRS
R4530 T6616 T6611 conj RRS,UDS
R4531 T6617 T6616 punct -,RRS
R4532 T6619 T6618 auxpass were,performed
R4533 T6620 T6621 mark as,described
R4534 T6621 T6618 advcl described,performed
R4535 T6622 T6621 advmod previously,described
R4536 T6623 T6624 punct [,30
R4537 T6624 T6618 parataxis 30,performed
R4538 T6625 T6624 nummod 21,30
R4539 T6626 T6624 punct ",",30
R4540 T6627 T6624 punct ],30
R4541 T6628 T6618 punct .,performed
R4542 T6630 T6631 prep For,presented
R4543 T6632 T6633 compound UV,RRS
R4544 T6633 T6630 pobj RRS,For
R4545 T6634 T6633 punct -,RRS
R4546 T6635 T6631 punct ", ",presented
R4547 T6636 T6637 amod average,values
R4548 T6637 T6631 nsubjpass values,presented
R4549 T6638 T6637 prep from,values
R4550 T6639 T6640 det the,experiment
R4551 T6640 T6638 pobj experiment,from
R4552 T6641 T6640 amod representative,experiment
R4553 T6642 T6640 acl containing,experiment
R4554 T6643 T6644 nummod two,wt
R4555 T6644 T6645 nmod wt,line
R4556 T6645 T6642 dobj line,containing
R4557 T6646 T6644 punct ", ",wt
R4558 T6647 T6648 nummod three,TTD
R4559 T6648 T6644 conj TTD,wt
R4560 T6649 T6648 compound XpdTTD,TTD
R4561 T6650 T6648 punct /,TTD
R4562 T6651 T6648 punct ", ",TTD
R4563 T6652 T6653 nummod two,XPCS
R4564 T6653 T6648 conj XPCS,TTD
R4565 T6654 T6653 compound XpdTTD,XPCS
R4566 T6655 T6653 punct /,XPCS
R4567 T6656 T6653 punct ", ",XPCS
R4568 T6657 T6653 cc and,XPCS
R4569 T6658 T6659 nummod one,XP
R4570 T6659 T6653 conj XP,XPCS
R4571 T6660 T6659 compound XpdTTD,XP
R4572 T6661 T6659 punct /,XP
R4573 T6662 T6645 compound cell,line
R4574 T6663 T6631 auxpass are,presented
R4575 T6664 T6631 punct .,presented
R4576 T6666 T6667 det The,value
R4577 T6667 T6674 nsubj value,differs
R4578 T6668 T6669 punct ~,48
R4579 T6669 T6670 nummod 48,%
R4580 T6670 T6667 compound %,value
R4581 T6671 T6672 compound UV,UDS
R4582 T6672 T6667 compound UDS,value
R4583 T6673 T6672 punct -,UDS
R4584 T6675 T6667 acl presented,value
R4585 T6676 T6675 prep in,presented
R4586 T6677 T6678 det this,study
R4587 T6678 T6676 pobj study,in
R4588 T6679 T6667 prep for,value
R4589 T6680 T6681 compound XpdTTD,TTD
R4590 T6681 T6683 compound TTD,cells
R4591 T6682 T6681 punct /,TTD
R4592 T6683 T6679 pobj cells,for
R4593 T6684 T6674 prep from,differs
R4594 T6685 T6686 poss our,data
R4595 T6686 T6684 pobj data,from
R4596 T6687 T6688 advmod previously,published
R4597 T6688 T6686 amod published,data
R4598 T6689 T6686 prep of,data
R4599 T6690 T6691 nummod 25,%
R4600 T6691 T6692 compound %,UDS
R4601 T6692 T6689 pobj UDS,of
R4602 T6693 T6692 compound UV,UDS
R4603 T6694 T6692 punct -,UDS
R4604 T6695 T6696 punct [,21
R4605 T6696 T6674 parataxis 21,differs
R4606 T6697 T6696 punct ],21
R4607 T6698 T6674 punct ", ",differs
R4608 T6699 T6700 advmod possibly,because
R4609 T6700 T6674 prep because,differs
R4610 T6701 T6700 prep of,because
R4611 T6702 T6703 det the,variability
R4612 T6703 T6701 pobj variability,of
R4613 T6704 T6703 amod high,variability
R4614 T6705 T6703 amod intrinsic,variability
R4615 T6706 T6705 prep to,intrinsic
R4616 T6707 T6708 det the,assay
R4617 T6708 T6706 pobj assay,to
R4618 T6709 T6708 cc or,assay
R4619 T6710 T6711 amod routine,variations
R4620 T6711 T6708 conj variations,assay
R4621 T6712 T6708 prep in,assay
R4622 T6713 T6714 det the,conditions
R4623 T6714 T6712 pobj conditions,in
R4624 T6715 T6716 compound cell,culture
R4625 T6716 T6714 compound culture,conditions
R4626 T6717 T6674 punct .,differs
R4627 T6719 T6720 prep For,prepared
R4628 T6721 T6722 det the,assay
R4629 T6722 T6719 pobj assay,For
R4630 T6723 T6724 compound incision,excision
R4631 T6724 T6722 compound excision,assay
R4632 T6725 T6724 punct /,excision
R4633 T6726 T6722 compound activity,assay
R4634 T6727 T6720 punct ", ",prepared
R4635 T6728 T6729 amod recombinant,TFIIH
R4636 T6729 T6720 nsubjpass TFIIH,prepared
R4637 T6730 T6720 auxpass was,prepared
R4638 T6731 T6720 cc and,prepared
R4639 T6732 T6720 conj assayed,prepared
R4640 T6733 T6734 mark as,described
R4641 T6734 T6732 advcl described,assayed
R4642 T6735 T6734 advmod previously,described
R4643 T6736 T6737 punct [,27
R4644 T6737 T6732 parataxis 27,assayed
R4645 T6738 T6737 punct ],27
R4646 T6739 T6720 punct .,prepared
R4649 T6770 T6771 amod Comparative,immunofluorescence
R4650 T6772 T6771 punct .,immunofluorescence
R4651 T6774 T6775 compound Latex,labelling
R4652 T6775 T6777 nsubjpass labelling,performed
R4653 T6776 T6775 compound bead,labelling
R4654 T6778 T6775 cc and,labelling
R4655 T6779 T6780 amod comparative,analysis
R4656 T6780 T6775 conj analysis,labelling
R4657 T6781 T6780 compound immunofluorescence,analysis
R4658 T6782 T6780 prep of,analysis
R4659 T6783 T6784 det the,subunit
R4660 T6784 T6782 pobj subunit,of
R4661 T6785 T6784 compound p62,subunit
R4662 T6786 T6784 prep of,subunit
R4663 T6787 T6788 det the,TFIIH
R4664 T6788 T6786 pobj TFIIH,of
R4665 T6789 T6777 auxpass was,performed
R4666 T6790 T6791 mark as,described
R4667 T6791 T6777 advcl described,performed
R4668 T6792 T6791 advmod previously,described
R4669 T6793 T6794 punct [,17
R4670 T6794 T6791 parataxis 17,described
R4671 T6795 T6794 nummod 16,17
R4672 T6796 T6794 punct ",",17
R4673 T6797 T6794 punct ],17
R4674 T6798 T6777 advcl using,performed
R4675 T6799 T6800 amod primary,fibroblasts
R4676 T6800 T6798 dobj fibroblasts,using
R4677 T6801 T6800 nmod mouse,fibroblasts
R4678 T6802 T6800 amod embryonic,fibroblasts
R4679 T6803 T6798 prep at,using
R4680 T6804 T6805 nmod passages,2
R4681 T6805 T6803 pobj 2,at
R4682 T6806 T6807 punct –,5
R4683 T6807 T6805 prep 5,2
R4684 T6808 T6777 punct .,performed
R4685 T6810 T6811 nummod Two,lines
R4686 T6811 T6815 nsubjpass lines,used
R4687 T6812 T6810 cc or,Two
R4688 T6813 T6810 conj more,Two
R4689 T6814 T6811 compound cell,lines
R4690 T6816 T6811 prep per,lines
R4691 T6817 T6816 pobj genotype,per
R4692 T6818 T6819 punct (,except
R4693 T6819 T6811 parataxis except,lines
R4694 T6820 T6819 prep for,except
R4695 T6821 T6822 det the,cells
R4696 T6822 T6820 pobj cells,for
R4697 T6823 T6824 compound XpdTTD,†XP
R4698 T6824 T6822 compound †XP,cells
R4699 T6825 T6824 punct /,†XP
R4700 T6826 T6822 punct ", ",cells
R4701 T6827 T6828 prep in,used
R4702 T6828 T6822 relcl used,cells
R4703 T6829 T6827 pobj which,in
R4704 T6830 T6831 advmod only,line
R4705 T6831 T6828 nsubjpass line,used
R4706 T6832 T6831 nummod one,line
R4707 T6833 T6831 compound cell,line
R4708 T6834 T6828 auxpass was,used
R4709 T6835 T6828 prep in,used
R4710 T6836 T6837 amod repeated,experiments
R4711 T6837 T6835 pobj experiments,in
R4712 T6838 T6819 punct ),except
R4713 T6839 T6815 auxpass were,used
R4714 T6840 T6815 punct ", ",used
R4715 T6841 T6815 cc and,used
R4716 T6842 T6843 nsubjpass experiments,repeated
R4717 T6843 T6815 conj repeated,used
R4718 T6844 T6843 auxpass were,repeated
R4719 T6845 T6846 compound 2,6
R4720 T6846 T6848 nummod 6,times
R4721 T6847 T6846 punct –,6
R4722 T6848 T6843 dobj times,repeated
R4723 T6849 T6848 prep per,times
R4724 T6850 T6849 pobj genotype,per
R4725 T6851 T6843 punct .,repeated
R4726 T7096 T7095 prep of,Targeting
R4727 T7097 T7098 det the,Gene
R4728 T7098 T7096 pobj Gene,of
R4729 T7099 T7098 compound Mouse,Gene
R4730 T7100 T7098 compound Xpd,Gene
R4731 T7102 T7103 punct (,A
R4732 T7103 T7104 meta A,representation
R4733 T7105 T7103 punct ),A
R4734 T7106 T7104 amod Schematic,representation
R4735 T7107 T7104 prep of,representation
R4736 T7108 T7109 det the,structure
R4737 T7109 T7107 pobj structure,of
R4738 T7110 T7109 amod genomic,structure
R4739 T7111 T7104 cc and,representation
R4740 T7112 T7113 amod partial,map
R4741 T7113 T7104 conj map,representation
R4742 T7114 T7113 compound restriction,map
R4743 T7115 T7113 prep of,map
R4744 T7116 T7117 det the,loci
R4745 T7117 T7115 pobj loci,of
R4746 T7118 T7117 nmod wt,loci
R4747 T7119 T7118 cc and,wt
R4748 T7120 T7118 conj targeted,wt
R4749 T7121 T7117 compound mouse,loci
R4750 T7122 T7117 compound Xpd,loci
R4751 T7123 T7113 punct .,map
R4752 T7125 T7126 prep For,represented
R4753 T7127 T7128 det the,allele
R4754 T7128 T7125 pobj allele,For
R4755 T7129 T7128 compound wt,allele
R4756 T7130 T7128 compound Xpd,allele
R4757 T7131 T7126 punct ", ",represented
R4758 T7132 T7133 amod shaded,boxes
R4759 T7133 T7134 nsubj boxes,represent
R4760 T7134 T7126 ccomp represent,represented
R4761 T7135 T7136 amod coding,regions
R4762 T7136 T7134 dobj regions,represent
R4763 T7137 T7136 prep of,regions
R4764 T7138 T7139 nmod exons,12
R4765 T7139 T7137 pobj 12,of
R4766 T7140 T7139 cc and,12
R4767 T7141 T7139 conj 19,12
R4768 T7142 T7143 punct –,23
R4769 T7143 T7141 prep 23,19
R4770 T7144 T7126 punct ;,represented
R4771 T7145 T7146 det the,UTR
R4772 T7146 T7126 nsubjpass UTR,represented
R4773 T7147 T7146 nummod 3,UTR
R4774 T7148 T7147 punct ′,3
R4775 T7149 T7126 auxpass is,represented
R4776 T7150 T7126 agent by,represented
R4777 T7151 T7152 det an,box
R4778 T7152 T7150 pobj box,by
R4779 T7153 T7152 amod open,box
R4780 T7154 T7126 punct .,represented
R4781 T7156 T7157 nsubj TGA,indicates
R4782 T7157 T7158 ccomp indicates,indicates
R4783 T7159 T7160 det the,codon
R4784 T7160 T7157 dobj codon,indicates
R4785 T7161 T7160 amod translational,codon
R4786 T7162 T7160 compound stop,codon
R4787 T7163 T7158 punct ;,indicates
R4788 T7164 T7158 nsubj PolyA,indicates
R4789 T7165 T7166 det the,signal
R4790 T7166 T7158 dobj signal,indicates
R4791 T7167 T7166 compound polyadenylation,signal
R4792 T7168 T7158 punct .,indicates
R4793 T7170 T7171 prep For,indicated
R4794 T7172 T7173 det the,allele
R4795 T7173 T7170 pobj allele,For
R4796 T7174 T7173 nmod XpdTTD,allele
R4797 T7175 T7173 amod targeted,allele
R4798 T7176 T7171 punct ", ",indicated
R4799 T7177 T7178 det the,fragment
R4800 T7178 T7171 nsubjpass fragment,indicated
R4801 T7179 T7180 nummod 194,pair
R4802 T7180 T7178 nmod pair,fragment
R4803 T7181 T7180 punct –,pair
R4804 T7182 T7180 nmod base,pair
R4805 T7183 T7180 punct (,pair
R4806 T7184 T7180 appos bp,pair
R4807 T7185 T7178 punct ),fragment
R4808 T7186 T7178 amod human,fragment
R4809 T7187 T7178 compound XPD,fragment
R4810 T7188 T7178 compound cDNA,fragment
R4811 T7189 T7178 acl fused,fragment
R4812 T7190 T7189 prep to,fused
R4813 T7191 T7190 pobj exon,to
R4814 T7192 T7191 nummod 22,exon
R4815 T7193 T7171 auxpass is,indicated
R4816 T7194 T7171 prep as,indicated
R4817 T7195 T7196 det a,box
R4818 T7196 T7194 pobj box,as
R4819 T7197 T7196 amod striped,box
R4820 T7198 T7171 prep including,indicated
R4821 T7199 T7200 det the,mutation
R4822 T7200 T7198 pobj mutation,including
R4823 T7201 T7200 nmod TTD,mutation
R4824 T7202 T7203 punct (,R722W
R4825 T7203 T7201 parataxis R722W,TTD
R4826 T7204 T7203 punct ),R722W
R4827 T7205 T7200 acl indicated,mutation
R4828 T7206 T7205 agent by,indicated
R4829 T7207 T7208 det a,arrow
R4830 T7208 T7206 pobj arrow,by
R4831 T7209 T7208 amod vertical,arrow
R4832 T7210 T7171 punct .,indicated
R4833 T7212 T7213 nmod Chicken,2
R4834 T7213 T7218 nsubjpass 2,indicated
R4835 T7214 T7215 nmod β,globin
R4836 T7215 T7213 nmod globin,2
R4837 T7216 T7215 punct -,globin
R4838 T7217 T7213 nmod exons,2
R4839 T7219 T7213 cc and,2
R4840 T7220 T7213 conj 3,2
R4841 T7221 T7213 prep including,2
R4842 T7222 T7223 det the,UTR
R4843 T7223 T7221 pobj UTR,including
R4844 T7224 T7223 nummod 3,UTR
R4845 T7225 T7224 punct ′,3
R4846 T7226 T7218 auxpass are,indicated
R4847 T7227 T7218 prep as,indicated
R4848 T7228 T7229 amod black,boxes
R4849 T7229 T7227 pobj boxes,as
R4850 T7230 T7229 prep with,boxes
R4851 T7231 T7232 amod corresponding,numerals
R4852 T7232 T7230 pobj numerals,with
R4853 T7233 T7232 compound Roman,numerals
R4854 T7234 T7232 acl followed,numerals
R4855 T7235 T7234 agent by,followed
R4856 T7236 T7237 det the,signal
R4857 T7237 T7235 pobj signal,by
R4858 T7238 T7239 compound β,globin
R4859 T7239 T7237 compound globin,signal
R4860 T7240 T7239 punct -,globin
R4861 T7241 T7237 compound polyadenylation,signal
R4862 T7242 T7243 punct (,PolyA*
R4863 T7243 T7237 parataxis PolyA*,signal
R4864 T7244 T7243 punct ),PolyA*
R4865 T7245 T7218 punct .,indicated
R4866 T7247 T7248 prep For,indicate
R4867 T7249 T7250 det the,alleles
R4868 T7250 T7247 pobj alleles,For
R4869 T7251 T7250 nmod Xpd†XP,alleles
R4870 T7252 T7251 cc and,Xpd†XP
R4871 T7253 T7251 conj Xpd†XPCS,Xpd†XP
R4872 T7254 T7250 amod targeted,alleles
R4873 T7255 T7248 punct ", ",indicate
R4874 T7256 T7257 amod vertical,arrows
R4875 T7257 T7248 nsubj arrows,indicate
R4876 T7258 T7259 nmod XPCS,mutations
R4877 T7259 T7248 dobj mutations,indicate
R4878 T7260 T7261 punct (,encoding
R4879 T7261 T7258 parataxis encoding,XPCS
R4880 T7262 T7261 npadvmod G602D,encoding
R4881 T7263 T7261 punct -,encoding
R4882 T7264 T7261 punct ),encoding
R4883 T7265 T7258 cc and,XPCS
R4884 T7266 T7258 conj XP,XPCS
R4885 T7267 T7268 punct (,encoding
R4886 T7268 T7266 parataxis encoding,XP
R4887 T7269 T7268 npadvmod R683W,encoding
R4888 T7270 T7268 punct -,encoding
R4889 T7271 T7268 punct ),encoding
R4890 T7272 T7259 prep in,mutations
R4891 T7273 T7274 nmod exons,19
R4892 T7274 T7272 pobj 19,in
R4893 T7275 T7274 cc and,19
R4894 T7276 T7274 conj 22,19
R4895 T7277 T7248 punct ", ",indicate
R4896 T7278 T7248 advmod respectively,indicate
R4897 T7279 T7248 punct .,indicate
R4898 T7281 T7282 det The,probe
R4899 T7282 T7286 nsubjpass probe,marked
R4900 T7283 T7282 amod unique,probe
R4901 T7284 T7282 nummod 3,probe
R4902 T7285 T7284 punct ′,3
R4903 T7287 T7282 acl located,probe
R4904 T7288 T7287 prep outside,located
R4905 T7289 T7290 det the,construct
R4906 T7290 T7288 pobj construct,outside
R4907 T7291 T7290 amod targeting,construct
R4908 T7292 T7286 auxpass is,marked
R4909 T7293 T7286 agent by,marked
R4910 T7294 T7295 det a,line
R4911 T7295 T7293 pobj line,by
R4912 T7296 T7295 amod thick,line
R4913 T7297 T7295 amod black,line
R4914 T7298 T7286 punct .,marked
R4915 T7300 T7301 compound Restriction,sites
R4916 T7302 T7301 punct : ,sites
R4917 T7303 T7301 appos B,sites
R4918 T7304 T7303 punct ", ",B
R4919 T7305 T7303 appos BamHI,B
R4920 T7306 T7303 punct ;,B
R4921 T7307 T7303 appos C,B
R4922 T7308 T7307 punct ", ",C
R4923 T7309 T7307 appos ClaI,C
R4924 T7310 T7303 punct ;,B
R4925 T7311 T7303 appos E,B
R4926 T7312 T7311 punct ", ",E
R4927 T7313 T7311 appos EcoRI,E
R4928 T7314 T7303 punct ;,B
R4929 T7315 T7303 appos H,B
R4930 T7316 T7315 punct ", ",H
R4931 T7317 T7315 appos HindIII,H
R4932 T7318 T7303 punct ;,B
R4933 T7319 T7303 appos Hp,B
R4934 T7320 T7319 punct ", ",Hp
R4935 T7321 T7319 appos HpaI,Hp
R4936 T7322 T7303 punct ;,B
R4937 T7323 T7303 appos Sf,B
R4938 T7324 T7323 punct ", ",Sf
R4939 T7325 T7323 appos SfiI,Sf
R4940 T7326 T7301 punct .,sites
R4941 T7328 T7329 punct (,B
R4942 T7329 T7330 meta B,analysis
R4943 T7331 T7329 punct ),B
R4944 T7332 T7333 compound Southern,blot
R4945 T7333 T7330 compound blot,analysis
R4946 T7334 T7330 prep of,analysis
R4947 T7335 T7336 npadvmod EcoRI,digested
R4948 T7336 T7338 amod digested,DNA
R4949 T7337 T7336 punct -,digested
R4950 T7338 T7334 pobj DNA,of
R4951 T7339 T7338 amod genomic,DNA
R4952 T7340 T7338 prep from,DNA
R4953 T7341 T7342 nmod wt,clones
R4954 T7342 T7340 pobj clones,from
R4955 T7343 T7341 punct ", ",wt
R4956 T7344 T7345 compound Xpd†XPCS,wt
R4957 T7345 T7341 conj wt,wt
R4958 T7346 T7345 punct /,wt
R4959 T7347 T7345 punct ", ",wt
R4960 T7348 T7345 cc and,wt
R4961 T7349 T7350 compound Xpd†XP,wt
R4962 T7350 T7345 conj wt,wt
R4963 T7351 T7350 punct /,wt
R4964 T7352 T7342 amod recombinant,clones
R4965 T7353 T7354 amod embryonic,cell
R4966 T7354 T7342 compound cell,clones
R4967 T7355 T7354 compound stem,cell
R4968 T7356 T7342 acl hybridised,clones
R4969 T7357 T7356 prep with,hybridised
R4970 T7358 T7359 det the,probe
R4971 T7359 T7357 pobj probe,with
R4972 T7360 T7359 nummod 3,probe
R4973 T7361 T7360 punct ′,3
R4974 T7362 T7359 acl depicted,probe
R4975 T7363 T7362 prep in,depicted
R4976 T7364 T7363 punct (,in
R4977 T7365 T7363 pobj A,in
R4978 T7366 T7330 punct ),analysis
R4979 T7367 T7330 punct .,analysis
R4980 T7369 T7370 det The,allele
R4981 T7370 T7372 nsubj allele,yields
R4982 T7371 T7370 compound wt,allele
R4983 T7373 T7374 det a,fragment
R4984 T7374 T7372 dobj fragment,yields
R4985 T7375 T7376 nummod 6.5,kilobase
R4986 T7376 T7374 nmod kilobase,fragment
R4987 T7377 T7376 punct -,kilobase
R4988 T7378 T7376 punct (,kilobase
R4989 T7379 T7376 appos kb,kilobase
R4990 T7380 T7374 punct ),fragment
R4991 T7381 T7372 punct ", ",yields
R4992 T7382 T7383 mark whereas,yield
R4993 T7383 T7372 advcl yield,yields
R4994 T7384 T7385 preconj both,alleles
R4995 T7385 T7383 nsubj alleles,yield
R4996 T7386 T7385 amod targeted,alleles
R4997 T7387 T7385 nmod Xpd†XP,alleles
R4998 T7388 T7387 cc and,Xpd†XP
R4999 T7389 T7387 conj Xpd†XPCS,Xpd†XP
R5000 T7390 T7391 det a,fragment
R5001 T7391 T7383 dobj fragment,yield
R5002 T7392 T7393 nummod 5.1,kb
R5003 T7393 T7391 compound kb,fragment
R5004 T7394 T7393 punct -,kb
R5005 T7395 T7372 punct .,yields
R5006 T7397 T7398 punct (,C
R5007 T7398 T7399 meta C,Genotyping
R5008 T7400 T7398 punct ),C
R5009 T7401 T7399 prep of,Genotyping
R5010 T7402 T7403 nmod wt,alleles
R5011 T7403 T7401 pobj alleles,of
R5012 T7404 T7402 cc and,wt
R5013 T7405 T7402 conj targeted,wt
R5014 T7406 T7399 prep by,Genotyping
R5015 T7407 T7406 pobj PCR,by
R5016 T7408 T7399 acl using,Genotyping
R5017 T7409 T7408 dobj primers,using
R5018 T7410 T7409 appos F2,primers
R5019 T7411 T7410 punct ", ",F2
R5020 T7412 T7410 conj R1,F2
R5021 T7413 T7412 punct ", ",R1
R5022 T7414 T7412 cc and,R1
R5023 T7415 T7412 conj mR,R1
R5024 T7416 T7417 mark as,indicated
R5025 T7417 T7408 advcl indicated,using
R5026 T7418 T7408 prep in,using
R5027 T7419 T7420 punct (,A
R5028 T7420 T7421 meta A,fragments
R5029 T7421 T7418 pobj fragments,in
R5030 T7422 T7420 punct ),A
R5031 T7423 T7421 nmod yields,fragments
R5032 T7424 T7421 prep of,fragments
R5033 T7425 T7426 nummod 399,bp
R5034 T7426 T7424 pobj bp,of
R5035 T7427 T7426 cc and,bp
R5036 T7428 T7429 nummod 468,bp
R5037 T7429 T7426 conj bp,bp
R5038 T7430 T7408 punct ", ",using
R5039 T7431 T7408 advmod respectively,using
R5040 T7432 T7399 punct .,Genotyping
R5041 T7434 T7435 punct (,D
R5042 T7435 T7436 meta D,results
R5043 T7437 T7435 punct ),D
R5044 T7438 T7439 compound RT,PCR
R5045 T7439 T7441 compound PCR,detection
R5046 T7440 T7439 punct -,PCR
R5047 T7441 T7436 nsubj detection,results
R5048 T7442 T7441 prep of,detection
R5049 T7443 T7444 compound mRNA,expression
R5050 T7444 T7442 pobj expression,of
R5051 T7445 T7444 acl originating,expression
R5052 T7446 T7445 prep from,originating
R5053 T7447 T7448 det the,alleles
R5054 T7448 T7446 pobj alleles,from
R5055 T7449 T7448 amod targeted,alleles
R5056 T7450 T7448 nmod †XP,alleles
R5057 T7451 T7450 cc and,†XP
R5058 T7452 T7450 conj †XPCS,†XP
R5059 T7453 T7441 prep in,detection
R5060 T7454 T7455 amod embryonic,cell
R5061 T7455 T7457 compound cell,clones
R5062 T7456 T7455 compound stem,cell
R5063 T7457 T7453 pobj clones,in
R5064 T7458 T7441 acl using,detection
R5065 T7459 T7458 dobj primers,using
R5066 T7460 T7459 appos F1,primers
R5067 T7461 T7462 punct (,hybridising
R5068 T7462 T7460 parataxis hybridising,F1
R5069 T7463 T7462 prep outside,hybridising
R5070 T7464 T7465 det the,construct
R5071 T7465 T7463 pobj construct,outside
R5072 T7466 T7465 amod targeting,construct
R5073 T7467 T7462 punct ),hybridising
R5074 T7468 T7460 cc and,F1
R5075 T7469 T7460 conj mR,F1
R5076 T7470 T7471 mark as,indicated
R5077 T7471 T7458 advcl indicated,using
R5078 T7472 T7471 prep in,indicated
R5079 T7473 T7472 punct (,in
R5080 T7474 T7472 pobj A,in
R5081 T7475 T7436 punct ),results
R5082 T7476 T7436 prep in,results
R5083 T7477 T7478 det a,fragment
R5084 T7478 T7476 pobj fragment,in
R5085 T7479 T7480 nummod "1,416",bp
R5086 T7480 T7478 compound bp,fragment
R5087 T7481 T7480 punct -,bp
R5088 T7482 T7436 punct .,results
R5089 T7484 T7485 punct (,E
R5090 T7485 T7486 meta E,analysis
R5091 T7487 T7485 punct ),E
R5092 T7488 T7489 compound Northern,blot
R5093 T7489 T7486 compound blot,analysis
R5094 T7490 T7486 prep of,analysis
R5095 T7491 T7492 amod total,RNA
R5096 T7492 T7490 pobj RNA,of
R5097 T7493 T7492 acl isolated,RNA
R5098 T7494 T7493 prep from,isolated
R5099 T7495 T7494 pobj testis,from
R5100 T7496 T7495 prep of,testis
R5101 T7497 T7498 amod homozygous,wt
R5102 T7498 T7499 nmod wt,mice
R5103 T7499 T7496 pobj mice,of
R5104 T7500 T7498 cc and,wt
R5105 T7501 T7502 compound XpdTTD,TTD
R5106 T7502 T7498 conj TTD,wt
R5107 T7503 T7502 punct /,TTD
R5108 T7504 T7498 punct ", ",wt
R5109 T7505 T7506 amod heterozygous,wt
R5110 T7506 T7498 conj wt,wt
R5111 T7507 T7506 compound Xpd†XPCS,wt
R5112 T7508 T7506 punct /,wt
R5113 T7509 T7506 cc and,wt
R5114 T7510 T7511 compound XpdTTD,wt
R5115 T7511 T7506 conj wt,wt
R5116 T7512 T7511 punct /,wt
R5117 T7513 T7506 punct ", ",wt
R5118 T7514 T7506 cc and,wt
R5119 T7515 T7516 amod compound,TTD
R5120 T7516 T7506 conj TTD,wt
R5121 T7517 T7516 amod heterozygous,TTD
R5122 T7518 T7516 compound Xpd†XPCS,TTD
R5123 T7519 T7516 punct /,TTD
R5124 T7520 T7521 mark as,indicated
R5125 T7521 T7493 advcl indicated,isolated
R5126 T7522 T7486 punct .,analysis
R5127 T7524 T7525 nsubj Hybridisation,detects
R5128 T7526 T7524 prep with,Hybridisation
R5129 T7527 T7528 det a,probe
R5130 T7528 T7526 pobj probe,with
R5131 T7529 T7530 nummod 1.4,kb
R5132 T7530 T7528 compound kb,probe
R5133 T7531 T7530 punct -,kb
R5134 T7532 T7528 compound mouse,probe
R5135 T7533 T7528 compound Xpd,probe
R5136 T7534 T7528 compound cDNA,probe
R5137 T7535 T7525 dobj mRNAs,detects
R5138 T7536 T7535 prep of,mRNAs
R5139 T7537 T7538 nummod 4,kb
R5140 T7538 T7536 pobj kb,of
R5141 T7539 T7537 punct ", ",4
R5142 T7540 T7537 conj 3.3,4
R5143 T7541 T7540 punct ", ",3.3
R5144 T7542 T7540 cc and,3.3
R5145 T7543 T7540 conj 2.7,3.3
R5146 T7544 T7535 prep from,mRNAs
R5147 T7545 T7546 nmod wt,alleles
R5148 T7546 T7544 pobj alleles,from
R5149 T7547 T7545 punct ", ",wt
R5150 T7548 T7545 conj Xpd†XPCS,wt
R5151 T7549 T7548 punct ", ",Xpd†XPCS
R5152 T7550 T7548 cc and,Xpd†XPCS
R5153 T7551 T7548 conj XpdTTD,Xpd†XPCS
R5154 T7552 T7535 punct ", ",mRNAs
R5155 T7553 T7535 advmod respectively,mRNAs
R5156 T7554 T7525 punct .,detects
R5157 T7556 T7557 det An,gel
R5158 T7557 T7565 nsubjpass gel,shown
R5159 T7558 T7559 compound ethidium,bromide
R5160 T7559 T7560 npadvmod bromide,stained
R5161 T7560 T7557 amod stained,gel
R5162 T7561 T7559 punct (,bromide
R5163 T7562 T7559 appos EtBr,bromide
R5164 T7563 T7560 punct ),stained
R5165 T7564 T7560 punct –,stained
R5166 T7566 T7557 acl showing,gel
R5167 T7567 T7568 det the,amount
R5168 T7568 T7566 dobj amount,showing
R5169 T7569 T7568 prep of,amount
R5170 T7570 T7571 amod total,RNA
R5171 T7571 T7569 pobj RNA,of
R5172 T7572 T7571 acl loaded,RNA
R5173 T7573 T7565 auxpass is,shown
R5174 T7574 T7565 advmod below,shown
R5175 T7575 T7565 punct .,shown
R5176 T7658 T7659 amod Partial,Rescue
R5177 T7660 T7659 prep of,Rescue
R5178 T7661 T7660 pobj TTD,of
R5179 T7662 T7661 amod Cutaneous,TTD
R5180 T7663 T7661 punct ", ",TTD
R5181 T7664 T7661 conj Blood,TTD
R5182 T7665 T7664 punct ", ",Blood
R5183 T7666 T7664 cc and,Blood
R5184 T7667 T7668 amod Developmental,Phenotypes
R5185 T7668 T7664 conj Phenotypes,Blood
R5186 T7669 T7659 prep in,Rescue
R5187 T7670 T7671 nmod Compound,Mice
R5188 T7671 T7669 pobj Mice,in
R5189 T7672 T7671 amod Heterozygous,Mice
R5190 T7673 T7674 compound XpdTTD,†XPCS
R5191 T7674 T7671 compound †XPCS,Mice
R5192 T7675 T7674 punct /,†XPCS
R5193 T7677 T7678 punct (,A
R5194 T7678 T7679 meta A,Photographs
R5195 T7680 T7678 punct ),A
R5196 T7681 T7679 prep of,Photographs
R5197 T7682 T7683 nummod 5,mo
R5198 T7683 T7685 npadvmod mo,old
R5199 T7684 T7683 punct -,mo
R5200 T7685 T7687 amod old,mice
R5201 T7686 T7685 punct -,old
R5202 T7687 T7681 pobj mice,of
R5203 T7688 T7689 amod homozygous,TTD
R5204 T7689 T7687 nmod TTD,mice
R5205 T7690 T7689 nmod XpdTTD,TTD
R5206 T7691 T7689 punct /,TTD
R5207 T7692 T7689 punct ", ",TTD
R5208 T7693 T7694 nmod compound,†XPCS
R5209 T7694 T7689 conj †XPCS,TTD
R5210 T7695 T7694 amod heterozygous,†XPCS
R5211 T7696 T7694 compound XpdTTD,†XPCS
R5212 T7697 T7694 punct /,†XPCS
R5213 T7698 T7694 punct ", ",†XPCS
R5214 T7699 T7694 cc and,†XPCS
R5215 T7700 T7694 conj wt,†XPCS
R5216 T7701 T7679 punct .,Photographs
R5217 T7704 T7703 punct : ,Insets
R5218 T7705 T7703 appos images,Insets
R5219 T7706 T7705 prep of,images
R5220 T7707 T7708 amod first,round
R5221 T7708 T7710 compound round,loss
R5222 T7709 T7708 punct -,round
R5223 T7710 T7706 pobj loss,of
R5224 T7711 T7710 compound hair,loss
R5225 T7712 T7703 punct .,Insets
R5226 T7714 T7715 punct (,B
R5227 T7715 T7716 meta B,analysis
R5228 T7717 T7715 punct ),B
R5229 T7718 T7716 amod Histological,analysis
R5230 T7719 T7716 prep of,analysis
R5231 T7720 T7721 det the,skin
R5232 T7721 T7719 pobj skin,of
R5233 T7722 T7721 prep of,skin
R5234 T7723 T7724 nmod XpdTTD,TTD
R5235 T7724 T7726 nmod TTD,mice
R5236 T7725 T7724 punct /,TTD
R5237 T7726 T7722 pobj mice,of
R5238 T7727 T7724 punct ", ",TTD
R5239 T7728 T7729 compound XpdTTD,†XPCS
R5240 T7729 T7724 conj †XPCS,TTD
R5241 T7730 T7729 punct /,†XPCS
R5242 T7731 T7729 punct ", ",†XPCS
R5243 T7732 T7729 cc and,†XPCS
R5244 T7733 T7729 conj wt,†XPCS
R5245 T7734 T7716 punct .,analysis
R5246 T7736 T7737 npadvmod TTD,associated
R5247 T7737 T7739 amod associated,acanthosis
R5248 T7738 T7737 punct -,associated
R5249 T7739 T7740 nsubj acanthosis,were
R5250 T7741 T7742 punct (,epidermis
R5251 T7742 T7739 parataxis epidermis,acanthosis
R5252 T7743 T7742 amod thicker,epidermis
R5253 T7744 T7742 punct ", ",epidermis
R5254 T7745 T7742 acl indicated,epidermis
R5255 T7746 T7745 agent by,indicated
R5256 T7747 T7748 amod solid,line
R5257 T7748 T7746 pobj line,by
R5258 T7749 T7748 amod vertical,line
R5259 T7750 T7742 punct ),epidermis
R5260 T7751 T7739 punct ", ",acanthosis
R5261 T7752 T7753 amod pronounced,layer
R5262 T7753 T7739 conj layer,acanthosis
R5263 T7754 T7753 amod granular,layer
R5264 T7755 T7753 punct (,layer
R5265 T7756 T7753 acl indicated,layer
R5266 T7757 T7756 agent by,indicated
R5267 T7758 T7757 pobj arrows,by
R5268 T7759 T7753 punct ),layer
R5269 T7760 T7753 punct ", ",layer
R5270 T7761 T7753 cc and,layer
R5271 T7762 T7763 amod sebacious,hyperplasia
R5272 T7763 T7753 conj hyperplasia,layer
R5273 T7764 T7763 compound gland,hyperplasia
R5274 T7765 T7763 punct (,hyperplasia
R5275 T7766 T7763 acl indicated,hyperplasia
R5276 T7767 T7766 agent by,indicated
R5277 T7768 T7769 amod dotted,line
R5278 T7769 T7767 pobj line,by
R5279 T7770 T7769 amod vertical,line
R5280 T7771 T7740 punct ),were
R5281 T7772 T7740 acomp absent,were
R5282 T7773 T7740 prep in,were
R5283 T7774 T7775 det the,epidermis
R5284 T7775 T7773 pobj epidermis,in
R5285 T7776 T7775 prep of,epidermis
R5286 T7777 T7778 nmod XpdTTD,†XPCS
R5287 T7778 T7780 nmod †XPCS,mice
R5288 T7779 T7778 punct /,†XPCS
R5289 T7780 T7776 pobj mice,of
R5290 T7781 T7778 cc and,†XPCS
R5291 T7782 T7778 conj wt,†XPCS
R5292 T7783 T7740 punct .,were
R5293 T7786 T7785 appos 400,Magnification
R5294 T7787 T7786 punct ×,400
R5295 T7788 T7785 punct .,Magnification
R5296 T7790 T7791 punct (,C
R5297 T7791 T7792 meta C,content
R5298 T7793 T7791 punct ),C
R5299 T7794 T7792 compound Cysteine,content
R5300 T7795 T7792 prep of,content
R5301 T7796 T7795 pobj hair,of
R5302 T7797 T7796 prep from,hair
R5303 T7798 T7799 nmod wt,mice
R5304 T7799 T7797 pobj mice,from
R5305 T7800 T7798 punct ", ",wt
R5306 T7801 T7802 compound XpdTTD,TTD
R5307 T7802 T7798 conj TTD,wt
R5308 T7803 T7802 punct /,TTD
R5309 T7804 T7802 punct ", ",TTD
R5310 T7805 T7802 cc and,TTD
R5311 T7806 T7807 compound XpdTTD,†XPCS
R5312 T7807 T7802 conj †XPCS,TTD
R5313 T7808 T7807 punct /,†XPCS
R5314 T7809 T7792 punct .,content
R5315 T7811 T7812 det The,value
R5316 T7812 T7815 nsubj value,indicates
R5317 T7813 T7812 compound p,value
R5318 T7814 T7812 punct -,value
R5319 T7816 T7817 amod significant,differences
R5320 T7817 T7815 dobj differences,indicates
R5321 T7818 T7817 prep between,differences
R5322 T7819 T7818 pobj mutants,between
R5323 T7820 T7819 cc and,mutants
R5324 T7821 T7819 conj wt,mutants
R5325 T7822 T7818 punct ", ",between
R5326 T7823 T7824 advmod as,as
R5327 T7824 T7818 cc as,between
R5328 T7825 T7824 advmod well,as
R5329 T7826 T7818 conj between,between
R5330 T7827 T7828 nmod XpdTTD,TTD
R5331 T7828 T7830 nmod TTD,mice
R5332 T7829 T7828 punct /,TTD
R5333 T7830 T7826 pobj mice,between
R5334 T7831 T7828 cc and,TTD
R5335 T7832 T7833 compound XpdTTD,†XPCS
R5336 T7833 T7828 conj †XPCS,TTD
R5337 T7834 T7833 punct /,†XPCS
R5338 T7835 T7815 punct .,indicates
R5339 T7837 T7838 compound Error,bars
R5340 T7838 T7839 nsubj bars,indicate
R5341 T7840 T7841 amod standard,error
R5342 T7841 T7839 dobj error,indicate
R5343 T7842 T7841 prep of,error
R5344 T7843 T7844 det the,mean
R5345 T7844 T7842 pobj mean,of
R5346 T7845 T7841 punct (,error
R5347 T7846 T7841 appos SEM,error
R5348 T7847 T7839 punct ),indicate
R5349 T7848 T7839 punct .,indicate
R5350 T7850 T7851 punct (,D
R5351 T7851 T7852 meta D,values
R5352 T7853 T7851 punct ),D
R5353 T7854 T7852 compound Hematocrit,values
R5354 T7855 T7852 prep from,values
R5355 T7856 T7855 pobj blood,from
R5356 T7857 T7856 prep of,blood
R5357 T7858 T7859 nmod XpdTTD,TTD
R5358 T7859 T7861 nmod TTD,mice
R5359 T7860 T7859 punct /,TTD
R5360 T7861 T7857 pobj mice,of
R5361 T7862 T7859 cc and,TTD
R5362 T7863 T7864 compound XpdTTD,†XPCS
R5363 T7864 T7859 conj †XPCS,TTD
R5364 T7865 T7864 punct /,†XPCS
R5365 T7866 T7852 punct .,values
R5366 T7868 T7869 det The,values
R5367 T7869 T7872 nsubj values,indicate
R5368 T7870 T7869 compound p,values
R5369 T7871 T7869 punct -,values
R5370 T7873 T7874 det the,significance
R5371 T7874 T7872 dobj significance,indicate
R5372 T7875 T7874 prep of,significance
R5373 T7876 T7877 det the,difference
R5374 T7877 T7875 pobj difference,of
R5375 T7878 T7872 advcl relative,indicate
R5376 T7879 T7878 prep to,relative
R5377 T7880 T7879 pobj wt,to
R5378 T7881 T7872 punct .,indicate
R5379 T7883 T7884 compound Error,bars
R5380 T7884 T7885 nsubj bars,indicate
R5381 T7886 T7885 dobj SEM,indicate
R5382 T7887 T7885 punct .,indicate
R5383 T7889 T7890 punct (,E
R5384 T7890 T7891 meta E,weights
R5385 T7892 T7890 punct ),E
R5386 T7893 T7891 compound Body,weights
R5387 T7894 T7891 prep of,weights
R5388 T7895 T7896 amod developing,mice
R5389 T7896 T7894 pobj mice,of
R5390 T7897 T7898 nmod XpdTTD,TTD
R5391 T7898 T7896 nmod TTD,mice
R5392 T7899 T7898 punct /,TTD
R5393 T7900 T7898 cc and,TTD
R5394 T7901 T7902 compound XpdTTD,†XPCS
R5395 T7902 T7898 conj †XPCS,TTD
R5396 T7903 T7902 punct /,†XPCS
R5397 T7904 T7896 prep after,mice
R5398 T7905 T7904 pobj weaning,after
R5399 T7906 T7891 acl plotted,weights
R5400 T7907 T7906 prep as,plotted
R5401 T7908 T7909 det a,percentage
R5402 T7909 T7907 pobj percentage,as
R5403 T7910 T7909 prep of,percentage
R5404 T7911 T7912 det the,weight
R5405 T7912 T7910 pobj weight,of
R5406 T7913 T7912 prep of,weight
R5407 T7914 T7915 npadvmod age,matched
R5408 T7915 T7917 amod matched,littermates
R5409 T7916 T7915 punct -,matched
R5410 T7917 T7913 pobj littermates,of
R5411 T7918 T7917 nmod control,littermates
R5412 T7919 T7917 nmod wt,littermates
R5413 T7920 T7919 cc and,wt
R5414 T7921 T7919 conj heterozygote,wt
R5415 T7922 T7923 punct (,hz
R5416 T7923 T7921 parataxis hz,heterozygote
R5417 T7924 T7923 punct ),hz
R5418 T7925 T7926 punct (,set
R5419 T7926 T7909 parataxis set,percentage
R5420 T7927 T7926 prep at,set
R5421 T7928 T7929 nummod 100,%
R5422 T7929 T7927 pobj %,at
R5423 T7930 T7926 punct ),set
R5424 T7931 T7891 punct .,weights
R5425 T7933 T7934 compound Error,bars
R5426 T7934 T7935 nsubj bars,indicate
R5427 T7936 T7935 dobj SEM,indicate
R5428 T7937 T7935 punct .,indicate
R5429 T8042 T8041 prep of,Rescue
R5430 T8043 T8044 npadvmod TTD,Associated
R5431 T8044 T8046 amod Associated,Features
R5432 T8045 T8044 punct -,Associated
R5433 T8046 T8042 pobj Features,of
R5434 T8047 T8046 amod Segmental,Features
R5435 T8048 T8046 amod Progeroid,Features
R5436 T8049 T8046 prep in,Features
R5437 T8050 T8051 amod Compound,Mice
R5438 T8051 T8049 pobj Mice,in
R5439 T8052 T8051 amod Heterozygous,Mice
R5440 T8053 T8054 compound Xpd TTD,†XPCS
R5441 T8054 T8051 compound †XPCS,Mice
R5442 T8055 T8054 punct /,†XPCS
R5443 T8057 T8058 punct (,A
R5444 T8058 T8059 meta A,Photographs
R5445 T8060 T8058 punct ),A
R5446 T8061 T8059 prep of,Photographs
R5447 T8062 T8063 nummod 20,mo
R5448 T8063 T8065 npadvmod mo,old
R5449 T8064 T8063 punct -,mo
R5450 T8065 T8067 amod old,mice
R5451 T8066 T8065 punct -,old
R5452 T8067 T8061 pobj mice,of
R5453 T8068 T8067 nmod wt,mice
R5454 T8069 T8068 punct ", ",wt
R5455 T8070 T8071 amod compound,†XPCS
R5456 T8071 T8068 conj †XPCS,wt
R5457 T8072 T8071 amod heterozygous,†XPCS
R5458 T8073 T8071 compound XpdTTD,†XPCS
R5459 T8074 T8071 punct /,†XPCS
R5460 T8075 T8071 punct ", ",†XPCS
R5461 T8076 T8071 cc and,†XPCS
R5462 T8077 T8078 amod homozygous,TTD
R5463 T8078 T8071 conj TTD,†XPCS
R5464 T8079 T8078 compound XpdTTD,TTD
R5465 T8080 T8078 punct /,TTD
R5466 T8081 T8059 punct .,Photographs
R5467 T8084 T8085 det the,cachexia
R5468 T8085 T8083 dobj cachexia,Note
R5469 T8086 T8085 amod extreme,cachexia
R5470 T8087 T8085 punct (,cachexia
R5471 T8088 T8085 appos lack,cachexia
R5472 T8089 T8088 prep of,lack
R5473 T8090 T8091 amod subcutaneous,fat
R5474 T8091 T8089 pobj fat,of
R5475 T8092 T8085 punct ),cachexia
R5476 T8093 T8085 prep in,cachexia
R5477 T8094 T8095 det the,mouse
R5478 T8095 T8093 pobj mouse,in
R5479 T8096 T8097 compound XpdTTD,TTD
R5480 T8097 T8095 compound TTD,mouse
R5481 T8098 T8097 punct /,TTD
R5482 T8099 T8083 cc and,Note
R5483 T8100 T8101 det the,absence
R5484 T8101 T8083 conj absence,Note
R5485 T8102 T8101 prep of,absence
R5486 T8103 T8104 det this,phenotype
R5487 T8104 T8102 pobj phenotype,of
R5488 T8105 T8101 prep in,absence
R5489 T8106 T8107 nmod wt,mice
R5490 T8107 T8105 pobj mice,in
R5491 T8108 T8106 cc and,wt
R5492 T8109 T8110 compound XpdTTD,†XPCS
R5493 T8110 T8106 conj †XPCS,wt
R5494 T8111 T8110 punct /,†XPCS
R5495 T8112 T8083 punct .,Note
R5496 T8114 T8115 punct (,B
R5497 T8115 T8116 meta B,Radiographs
R5498 T8117 T8115 punct ),B
R5499 T8118 T8116 prep of,Radiographs
R5500 T8119 T8120 nummod 20,mo
R5501 T8120 T8122 npadvmod mo,old
R5502 T8121 T8120 punct -,mo
R5503 T8122 T8124 amod old,mice
R5504 T8123 T8122 punct -,old
R5505 T8124 T8118 pobj mice,of
R5506 T8125 T8124 amod male,mice
R5507 T8126 T8124 nmod wt,mice
R5508 T8127 T8126 punct ", ",wt
R5509 T8128 T8129 compound XpdTTD,†XPCS
R5510 T8129 T8126 conj †XPCS,wt
R5511 T8130 T8129 punct /,†XPCS
R5512 T8131 T8129 punct ", ",†XPCS
R5513 T8132 T8129 cc and,†XPCS
R5514 T8133 T8134 compound XpdTTD,TTD
R5515 T8134 T8129 conj TTD,†XPCS
R5516 T8135 T8134 punct /,TTD
R5517 T8136 T8116 punct .,Radiographs
R5518 T8138 T8139 amod Ageing,mice
R5519 T8139 T8143 nsubj mice,develop
R5520 T8140 T8141 compound XpdTTD,TTD
R5521 T8141 T8139 compound TTD,mice
R5522 T8142 T8141 punct /,TTD
R5523 T8144 T8143 dobj kyphosis,develop
R5524 T8145 T8144 punct (,kyphosis
R5525 T8146 T8144 appos curvature,kyphosis
R5526 T8147 T8146 prep of,curvature
R5527 T8148 T8149 det the,column
R5528 T8149 T8147 pobj column,of
R5529 T8150 T8149 amod spinal,column
R5530 T8151 T8144 punct ),kyphosis
R5531 T8152 T8144 cc and,kyphosis
R5532 T8153 T8144 conj reduction,kyphosis
R5533 T8154 T8153 prep of,reduction
R5534 T8155 T8156 compound bone,mineral
R5535 T8156 T8157 compound mineral,density
R5536 T8157 T8154 pobj density,of
R5537 T8158 T8159 mark as,shown
R5538 T8159 T8143 advcl shown,develop
R5539 T8160 T8159 prep in,shown
R5540 T8161 T8162 det the,segment
R5541 T8162 T8160 pobj segment,in
R5542 T8163 T8164 quantmod 6,8
R5543 T8164 T8162 nummod 8,segment
R5544 T8165 T8164 punct –,8
R5545 T8166 T8162 prep of,segment
R5546 T8167 T8168 det the,vertebrae
R5547 T8168 T8166 pobj vertebrae,of
R5548 T8169 T8168 compound tail,vertebrae
R5549 T8170 T8162 acl counted,segment
R5550 T8171 T8170 prep from,counted
R5551 T8172 T8173 det the,pelvis
R5552 T8173 T8171 pobj pelvis,from
R5553 T8174 T8175 punct (,see
R5554 T8175 T8143 parataxis see,develop
R5555 T8176 T8175 dobj close,see
R5556 T8177 T8176 punct -,close
R5557 T8178 T8176 prt up,close
R5558 T8179 T8176 prep at,close
R5559 T8180 T8179 pobj right,at
R5560 T8181 T8175 punct ),see
R5561 T8182 T8143 punct .,develop
R5562 T8185 T8186 det the,absence
R5563 T8186 T8184 dobj absence,Note
R5564 T8187 T8186 prep of,absence
R5565 T8188 T8189 det these,features
R5566 T8189 T8187 pobj features,of
R5567 T8190 T8186 prep in,absence
R5568 T8191 T8192 det the,mouse
R5569 T8192 T8190 pobj mouse,in
R5570 T8193 T8194 compound XpdTTD , † XPCS
R5571 T8194 T8192 compound  † XPCS,mouse
R5572 T8195 T8194 punct /, † XPCS
R5573 T8196 T8184 punct .,Note
R5574 T8198 T8199 punct (,C
R5575 T8199 T8200 meta C,Quantification
R5576 T8201 T8199 punct ),C
R5577 T8202 T8200 prep of,Quantification
R5578 T8203 T8204 amod relative,density
R5579 T8204 T8202 pobj density,of
R5580 T8205 T8206 compound bone,mineral
R5581 T8206 T8204 compound mineral,density
R5582 T8207 T8204 prep of,density
R5583 T8208 T8209 compound tail,vertebrae
R5584 T8209 T8207 pobj vertebrae,of
R5585 T8210 T8209 prep from,vertebrae
R5586 T8211 T8212 nummod 20,mo
R5587 T8212 T8214 npadvmod mo,old
R5588 T8213 T8212 punct -,mo
R5589 T8214 T8216 amod old,mice
R5590 T8215 T8214 punct -,old
R5591 T8216 T8210 pobj mice,from
R5592 T8217 T8216 amod male,mice
R5593 T8218 T8216 nmod wt,mice
R5594 T8219 T8220 punct (,3
R5595 T8220 T8218 parataxis 3,wt
R5596 T8221 T8220 nsubj n,3
R5597 T8222 T8220 punct =,3
R5598 T8223 T8220 punct ),3
R5599 T8224 T8218 punct ", ",wt
R5600 T8225 T8226 compound XpdTTD,†XPCS
R5601 T8226 T8218 conj †XPCS,wt
R5602 T8227 T8226 punct /,†XPCS
R5603 T8228 T8229 punct (,4
R5604 T8229 T8226 parataxis 4,†XPCS
R5605 T8230 T8229 nsubj n,4
R5606 T8231 T8229 punct =,4
R5607 T8232 T8229 punct ),4
R5608 T8233 T8226 punct ", ",†XPCS
R5609 T8234 T8226 cc and,†XPCS
R5610 T8235 T8236 compound XpdTTD,TTD
R5611 T8236 T8226 conj TTD,†XPCS
R5612 T8237 T8236 punct /,TTD
R5613 T8238 T8239 punct (,3
R5614 T8239 T8236 parataxis 3,TTD
R5615 T8240 T8239 nsubj n,3
R5616 T8241 T8239 punct =,3
R5617 T8242 T8239 punct ),3
R5618 T8243 T8200 punct .,Quantification
R5619 T8245 T8246 det The,values
R5620 T8246 T8249 nsubj values,indicate
R5621 T8247 T8246 compound p,values
R5622 T8248 T8246 punct -,values
R5623 T8250 T8251 det the,significance
R5624 T8251 T8249 dobj significance,indicate
R5625 T8252 T8251 prep of,significance
R5626 T8253 T8254 det the,difference
R5627 T8254 T8252 pobj difference,of
R5628 T8255 T8249 advcl relative,indicate
R5629 T8256 T8255 prep to,relative
R5630 T8257 T8258 compound XpdTTD,TTD
R5631 T8258 T8256 pobj TTD,to
R5632 T8259 T8258 punct /,TTD
R5633 T8260 T8249 punct .,indicate
R5634 T8262 T8263 compound Error,bars
R5635 T8263 T8264 nsubj bars,indicate
R5636 T8265 T8264 dobj SEM,indicate
R5637 T8266 T8264 punct .,indicate
R5638 T8268 T8269 punct (,D
R5639 T8269 T8270 meta D,curves
R5640 T8271 T8269 punct ),D
R5641 T8272 T8273 compound Body,weight
R5642 T8273 T8270 compound weight,curves
R5643 T8274 T8270 prep as,curves
R5644 T8275 T8276 det a,function
R5645 T8276 T8274 pobj function,as
R5646 T8277 T8276 prep of,function
R5647 T8278 T8277 pobj time,of
R5648 T8279 T8270 punct .,curves
R5649 T8282 T8283 mark that,rescued
R5650 T8283 T8281 ccomp rescued,Note
R5651 T8284 T8285 det the,cachexia
R5652 T8285 T8283 nsubjpass cachexia,rescued
R5653 T8286 T8287 npadvmod age,dependent
R5654 T8287 T8285 amod dependent,cachexia
R5655 T8288 T8287 punct -,dependent
R5656 T8289 T8285 acl observed,cachexia
R5657 T8290 T8289 prep in,observed
R5658 T8291 T8292 compound XpdTTD,TTD
R5659 T8292 T8294 compound TTD,mice
R5660 T8293 T8292 punct /,TTD
R5661 T8294 T8290 pobj mice,in
R5662 T8295 T8283 auxpass was,rescued
R5663 T8296 T8283 prep in,rescued
R5664 T8297 T8298 preconj both,male
R5665 T8298 T8299 nmod male,mice
R5666 T8299 T8296 pobj mice,in
R5667 T8300 T8298 cc and,male
R5668 T8301 T8298 conj female,male
R5669 T8302 T8303 compound XpdTTD , †XPCS
R5670 T8303 T8299 compound  †XPCS,mice
R5671 T8304 T8303 punct /, †XPCS
R5672 T8305 T8281 punct .,Note
R5673 T8307 T8308 amod Significant,differences
R5674 T8308 T8309 nsubjpass differences,observed
R5675 T8310 T8308 prep between,differences
R5676 T8311 T8310 pobj wt,between
R5677 T8312 T8311 cc and,wt
R5678 T8313 T8314 compound XpdTTD,TTD
R5679 T8314 T8311 conj TTD,wt
R5680 T8315 T8314 punct /,TTD
R5681 T8316 T8310 cc but,between
R5682 T8317 T8316 neg not,but
R5683 T8318 T8310 conj between,between
R5684 T8319 T8320 nmod wt,mice
R5685 T8320 T8318 pobj mice,between
R5686 T8321 T8319 cc and,wt
R5687 T8322 T8323 compound XpdTTD,†XPCS
R5688 T8323 T8319 conj †XPCS,wt
R5689 T8324 T8323 punct /,†XPCS
R5690 T8325 T8309 auxpass were,observed
R5691 T8326 T8309 prep at,observed
R5692 T8327 T8328 nummod 9,mo
R5693 T8328 T8326 pobj mo,at
R5694 T8329 T8327 cc and,9
R5695 T8330 T8327 conj 18,9
R5696 T8331 T8328 prep of,mo
R5697 T8332 T8331 pobj age,of
R5698 T8333 T8334 mark as,indicated
R5699 T8334 T8309 advcl indicated,observed
R5700 T8335 T8334 agent by,indicated
R5701 T8336 T8335 pobj asterisks,by
R5702 T8337 T8309 punct .,observed
R5703 T8339 T8340 compound Error,bars
R5704 T8340 T8341 nsubj bars,indicate
R5705 T8342 T8341 dobj SEM,indicate
R5706 T8343 T8341 punct .,indicate
R5707 T8564 T8565 compound TFIIH,Functions
R5708 T8566 T8565 cc and,Functions
R5709 T8567 T8565 conj Mechanisms,Functions
R5710 T8568 T8567 prep of,Mechanisms
R5711 T8569 T8570 npadvmod XPD,Associated
R5712 T8570 T8572 amod Associated,Pleiotropy
R5713 T8571 T8570 punct -,Associated
R5714 T8572 T8568 pobj Pleiotropy,of
R5715 T8573 T8572 compound Disease,Pleiotropy
R5716 T8575 T8576 punct (,A
R5717 T8576 T8577 meta A,survival
R5718 T8578 T8576 punct ),A
R5719 T8579 T8577 amod Cellular,survival
R5720 T8580 T8577 prep after,survival
R5721 T8581 T8582 compound UV,irradiation
R5722 T8582 T8580 pobj irradiation,after
R5723 T8583 T8577 punct .,survival
R5724 T8585 T8586 nsubjpass Rescue,illustrated
R5725 T8587 T8585 prep of,Rescue
R5726 T8588 T8589 amod hemizygous,survival
R5727 T8589 T8587 pobj survival,of
R5728 T8590 T8591 compound XpdTTD,KO
R5729 T8591 T8589 compound KO,survival
R5730 T8592 T8591 punct /,KO
R5731 T8593 T8585 prep by,Rescue
R5732 T8594 T8595 nmod Xpd†XPCS,alleles
R5733 T8595 T8593 pobj alleles,by
R5734 T8596 T8594 cc and,Xpd†XPCS
R5735 T8597 T8594 conj Xpd†XP,Xpd†XPCS
R5736 T8598 T8586 auxpass is,illustrated
R5737 T8599 T8586 agent by,illustrated
R5738 T8600 T8599 pobj arrows,by
R5739 T8601 T8600 acl marked,arrows
R5740 T8602 T8601 oprd A,marked
R5741 T8603 T8602 cc and,A
R5742 T8604 T8602 conj B,A
R5743 T8605 T8601 punct ", ",marked
R5744 T8606 T8601 advmod respectively,marked
R5745 T8607 T8586 punct .,illustrated
R5746 T8609 T8610 compound UV,survival
R5747 T8610 T8611 nsubjpass survival,depicted
R5748 T8612 T8610 prep of,survival
R5749 T8613 T8614 amod homozygous,cells
R5750 T8614 T8612 pobj cells,of
R5751 T8615 T8616 compound XpdXPCS,XPCS
R5752 T8616 T8614 compound XPCS,cells
R5753 T8617 T8616 punct /,XPCS
R5754 T8618 T8619 punct (,asterisk
R5755 T8619 T8614 parataxis asterisk,cells
R5756 T8620 T8619 punct ),asterisk
R5757 T8621 T8614 prep from,cells
R5758 T8622 T8623 det the,allele
R5759 T8623 T8621 pobj allele,from
R5760 T8624 T8625 advmod normally,expressed
R5761 T8625 T8623 amod expressed,allele
R5762 T8626 T8623 amod viable,allele
R5763 T8627 T8628 punct (,XpdXPCS
R5764 T8628 T8623 parataxis XpdXPCS,allele
R5765 T8629 T8628 punct ),XpdXPCS
R5766 T8630 T8611 auxpass is,depicted
R5767 T8631 T8611 prep by,depicted
R5768 T8632 T8633 det a,line
R5769 T8633 T8631 pobj line,by
R5770 T8634 T8633 amod dotted,line
R5771 T8635 T8611 punct .,depicted
R5772 T8637 T8638 compound Survival,curves
R5773 T8638 T8639 nsubj curves,represent
R5774 T8639 T8640 ccomp represent,included
R5775 T8641 T8642 det an,average
R5776 T8642 T8639 dobj average,represent
R5777 T8643 T8642 prep of,average
R5778 T8644 T8645 nummod four,experiments
R5779 T8645 T8643 pobj experiments,of
R5780 T8646 T8645 amod independent,experiments
R5781 T8647 T8640 punct ;,included
R5782 T8648 T8649 quantmod 1,2
R5783 T8649 T8651 nummod 2,lines
R5784 T8650 T8649 punct –,2
R5785 T8651 T8640 nsubjpass lines,included
R5786 T8652 T8651 compound cell,lines
R5787 T8653 T8651 prep per,lines
R5788 T8654 T8653 pobj genotype,per
R5789 T8655 T8640 auxpass were,included
R5790 T8656 T8640 prep in,included
R5791 T8657 T8658 det each,experiment
R5792 T8658 T8656 pobj experiment,in
R5793 T8659 T8640 punct .,included
R5794 T8661 T8662 compound Error,bars
R5795 T8662 T8663 nsubj bars,indicate
R5796 T8664 T8663 dobj SEM,indicate
R5797 T8665 T8664 prep between,SEM
R5798 T8666 T8665 pobj experiments,between
R5799 T8667 T8663 punct .,indicate
R5800 T8669 T8670 punct (,B
R5801 T8670 T8671 meta B,UDS
R5802 T8672 T8670 punct ),B
R5803 T8673 T8671 compound UV,UDS
R5804 T8674 T8671 punct -,UDS
R5805 T8675 T8671 punct ", ",UDS
R5806 T8676 T8677 det a,measure
R5807 T8677 T8671 appos measure,UDS
R5808 T8678 T8677 prep of,measure
R5809 T8679 T8680 amod global,repair
R5810 T8680 T8678 pobj repair,of
R5811 T8681 T8680 compound genome,repair
R5812 T8682 T8671 punct .,UDS
R5813 T8684 T8685 dep Number,included
R5814 T8686 T8684 prep of,Number
R5815 T8687 T8686 pobj experiments,of
R5816 T8688 T8685 punct : ,included
R5817 T8689 T8690 nsubj n,15
R5818 T8690 T8685 ccomp 15,included
R5819 T8691 T8690 punct =,15
R5820 T8692 T8693 punct (,XpdTTD
R5821 T8693 T8690 parataxis XpdTTD,15
R5822 T8694 T8693 punct /,XpdTTD
R5823 T8695 T8693 dep TTD,XpdTTD
R5824 T8696 T8693 punct ),XpdTTD
R5825 T8697 T8685 punct ", ",included
R5826 T8698 T8699 nsubj n,6
R5827 T8699 T8685 ccomp 6,included
R5828 T8700 T8699 punct =,6
R5829 T8701 T8702 punct (,KO
R5830 T8702 T8699 parataxis KO,6
R5831 T8703 T8702 compound XpdTTD,KO
R5832 T8704 T8702 punct /,KO
R5833 T8705 T8702 punct ),KO
R5834 T8706 T8685 punct ", ",included
R5835 T8707 T8708 nsubj n,4
R5836 T8708 T8685 ccomp 4,included
R5837 T8709 T8708 punct =,4
R5838 T8710 T8711 punct (,†XPCS
R5839 T8711 T8708 parataxis †XPCS,4
R5840 T8712 T8711 compound XpdTTD,†XPCS
R5841 T8713 T8711 punct /,†XPCS
R5842 T8714 T8711 punct ),†XPCS
R5843 T8715 T8685 punct ", ",included
R5844 T8716 T8717 nsubj n,2
R5845 T8717 T8685 ccomp 2,included
R5846 T8718 T8717 punct =,2
R5847 T8719 T8720 punct (,†XP
R5848 T8720 T8717 parataxis †XP,2
R5849 T8721 T8720 compound XpdTTD,†XP
R5850 T8722 T8720 punct /,†XP
R5851 T8723 T8720 punct ),†XP
R5852 T8724 T8685 punct ;,included
R5853 T8725 T8726 quantmod 1,2
R5854 T8726 T8728 nummod 2,lines
R5855 T8727 T8726 punct –,2
R5856 T8728 T8685 nsubjpass lines,included
R5857 T8729 T8728 compound cell,lines
R5858 T8730 T8728 prep per,lines
R5859 T8731 T8730 pobj genotype,per
R5860 T8732 T8685 auxpass were,included
R5861 T8733 T8685 prep in,included
R5862 T8734 T8735 det each,experiment
R5863 T8735 T8733 pobj experiment,in
R5864 T8736 T8685 punct .,included
R5865 T8738 T8739 det The,asterisk
R5866 T8739 T8740 nsubj asterisk,indicates
R5867 T8740 T8741 ccomp indicates,indicate
R5868 T8742 T8743 amod significant,difference
R5869 T8743 T8740 dobj difference,indicates
R5870 T8744 T8743 prep with,difference
R5871 T8745 T8746 compound XpdTTD,TTD
R5872 T8746 T8744 pobj TTD,with
R5873 T8747 T8746 punct /,TTD
R5874 T8748 T8741 punct ;,indicate
R5875 T8749 T8741 nsubj crosses,indicate
R5876 T8750 T8751 amod significant,differences
R5877 T8751 T8741 dobj differences,indicate
R5878 T8752 T8751 prep with,differences
R5879 T8753 T8754 compound XpdTTD,KO
R5880 T8754 T8752 pobj KO,with
R5881 T8755 T8754 punct /,KO
R5882 T8756 T8741 punct .,indicate
R5883 T8758 T8759 punct (,C
R5884 T8759 T8760 meta C,RRS
R5885 T8761 T8759 punct ),C
R5886 T8762 T8760 compound UV,RRS
R5887 T8763 T8760 punct -,RRS
R5888 T8764 T8760 punct ", ",RRS
R5889 T8765 T8766 det a,measure
R5890 T8766 T8760 appos measure,RRS
R5891 T8767 T8766 prep of,measure
R5892 T8768 T8769 npadvmod transcription,coupled
R5893 T8769 T8771 amod coupled,repair
R5894 T8770 T8769 punct -,coupled
R5895 T8771 T8767 pobj repair,of
R5896 T8772 T8771 prep of,repair
R5897 T8773 T8774 npadvmod UV,induced
R5898 T8774 T8776 amod induced,lesions
R5899 T8775 T8774 punct -,induced
R5900 T8776 T8772 pobj lesions,of
R5901 T8777 T8760 punct .,RRS
R5902 T8779 T8780 dep Number,included
R5903 T8781 T8779 prep of,Number
R5904 T8782 T8781 pobj experiments,of
R5905 T8783 T8780 punct : ,included
R5906 T8784 T8785 nsubj n,7
R5907 T8785 T8780 ccomp 7,included
R5908 T8786 T8785 punct =,7
R5909 T8787 T8788 punct (,TTD
R5910 T8788 T8785 parataxis TTD,7
R5911 T8789 T8788 compound XpdTTD,TTD
R5912 T8790 T8788 punct /,TTD
R5913 T8791 T8788 punct ),TTD
R5914 T8792 T8780 punct ", ",included
R5915 T8793 T8794 nsubj n,2
R5916 T8794 T8780 ccomp 2,included
R5917 T8795 T8794 punct =,2
R5918 T8796 T8797 punct (,KO
R5919 T8797 T8794 parataxis KO,2
R5920 T8798 T8797 compound XpdTTD,KO
R5921 T8799 T8797 punct /,KO
R5922 T8800 T8797 punct ),KO
R5923 T8801 T8780 punct ", ",included
R5924 T8802 T8803 nsubj n,4
R5925 T8803 T8780 ccomp 4,included
R5926 T8804 T8803 punct =,4
R5927 T8805 T8806 punct (,†XPCS
R5928 T8806 T8803 parataxis †XPCS,4
R5929 T8807 T8806 compound XpdTTD,†XPCS
R5930 T8808 T8806 punct /,†XPCS
R5931 T8809 T8806 punct ),†XPCS
R5932 T8810 T8780 punct ", ",included
R5933 T8811 T8812 nsubj n,2
R5934 T8812 T8780 ccomp 2,included
R5935 T8813 T8812 punct =,2
R5936 T8814 T8815 punct (,†XP
R5937 T8815 T8812 parataxis †XP,2
R5938 T8816 T8815 compound XpdTTD,†XP
R5939 T8817 T8815 punct /,†XP
R5940 T8818 T8815 punct ),†XP
R5941 T8819 T8780 punct ;,included
R5942 T8820 T8821 quantmod 1,2
R5943 T8821 T8823 nummod 2,lines
R5944 T8822 T8821 punct –,2
R5945 T8823 T8780 nsubjpass lines,included
R5946 T8824 T8823 compound cell,lines
R5947 T8825 T8823 prep per,lines
R5948 T8826 T8825 pobj genotype,per
R5949 T8827 T8780 auxpass were,included
R5950 T8828 T8780 prep in,included
R5951 T8829 T8830 det each,experiment
R5952 T8830 T8828 pobj experiment,in
R5953 T8831 T8780 punct .,included
R5954 T8833 T8834 punct (,D
R5955 T8834 T8835 meta D,activity
R5956 T8836 T8834 punct ),D
R5957 T8837 T8838 compound Incision,excision
R5958 T8838 T8835 compound excision,activity
R5959 T8839 T8838 punct /,excision
R5960 T8840 T8835 prep of,activity
R5961 T8841 T8840 pobj combinations,of
R5962 T8842 T8841 prep of,combinations
R5963 T8843 T8844 amod altered,complexes
R5964 T8844 T8842 pobj complexes,of
R5965 T8845 T8844 compound TFIIH,complexes
R5966 T8846 T8844 prep in,complexes
R5967 T8847 T8848 det a,reaction
R5968 T8848 T8846 pobj reaction,in
R5969 T8849 T8848 amod reconstituted,reaction
R5970 T8850 T8848 compound NER,reaction
R5971 T8851 T8835 punct .,activity
R5972 T8853 T8854 amod Equal,amounts
R5973 T8854 T8855 nsubjpass amounts,mixed
R5974 T8856 T8854 prep of,amounts
R5975 T8857 T8858 amod single,populations
R5976 T8858 T8856 pobj populations,of
R5977 T8859 T8857 cc or,single
R5978 T8860 T8857 conj mixed,single
R5979 T8861 T8858 prep of,populations
R5980 T8862 T8863 amod recombinant,TFIIHs
R5981 T8863 T8861 pobj TFIIHs,of
R5982 T8864 T8858 punct (,populations
R5983 T8865 T8858 acl containing,populations
R5984 T8866 T8865 dobj XPD,containing
R5985 T8867 T8866 punct ", ",XPD
R5986 T8868 T8866 conj XPB,XPD
R5987 T8869 T8868 punct ", ",XPB
R5988 T8870 T8868 conj p62,XPB
R5989 T8871 T8870 punct ", ",p62
R5990 T8872 T8870 conj p52,p62
R5991 T8873 T8872 punct ", ",p52
R5992 T8874 T8875 compound His,p44
R5993 T8875 T8872 conj p44,p52
R5994 T8876 T8875 punct -,p44
R5995 T8877 T8875 punct ", ",p44
R5996 T8878 T8879 compound Flag,p34
R5997 T8879 T8875 conj p34,p44
R5998 T8880 T8879 punct -,p34
R5999 T8881 T8879 punct ", ",p34
R6000 T8882 T8879 conj cdk7,p34
R6001 T8883 T8882 punct ", ",cdk7
R6002 T8884 T8885 compound cyclin,H
R6003 T8885 T8882 conj H,cdk7
R6004 T8886 T8885 punct ", ",H
R6005 T8887 T8885 conj Mat1,H
R6006 T8888 T8887 punct ", ",Mat1
R6007 T8889 T8887 cc and,Mat1
R6008 T8890 T8887 conj p8,Mat1
R6009 T8891 T8855 punct ),mixed
R6010 T8892 T8855 auxpass were,mixed
R6011 T8893 T8855 prep with,mixed
R6012 T8894 T8895 amod recombinant,XPG
R6013 T8895 T8893 pobj XPG,with
R6014 T8896 T8895 punct ", ",XPG
R6015 T8897 T8898 compound XPF,ERCC1
R6016 T8898 T8895 appos ERCC1,XPG
R6017 T8899 T8898 punct /,ERCC1
R6018 T8900 T8895 punct ", ",XPG
R6019 T8901 T8902 compound XPC,hHR23B
R6020 T8902 T8895 appos hHR23B,XPG
R6021 T8903 T8902 punct /,hHR23B
R6022 T8904 T8895 punct ", ",XPG
R6023 T8905 T8895 appos RPA,XPG
R6024 T8906 T8895 punct ", ",XPG
R6025 T8907 T8895 cc and,XPG
R6026 T8908 T8909 det a,substrate
R6027 T8909 T8895 conj substrate,XPG
R6028 T8910 T8909 amod radiolabelled,substrate
R6029 T8911 T8909 amod synthetic,substrate
R6030 T8912 T8909 compound NER,substrate
R6031 T8913 T8855 punct .,mixed
R6032 T8915 T8916 det The,products
R6033 T8916 T8918 nsubjpass products,visualised
R6034 T8917 T8916 compound excision,products
R6035 T8919 T8920 punct (,nucleotides
R6036 T8920 T8916 parataxis nucleotides,products
R6037 T8921 T8922 quantmod 26,34
R6038 T8922 T8920 nummod 34,nucleotides
R6039 T8923 T8922 punct –,34
R6040 T8924 T8920 prep in,nucleotides
R6041 T8925 T8924 pobj length,in
R6042 T8926 T8920 punct ),nucleotides
R6043 T8927 T8918 auxpass were,visualised
R6044 T8928 T8918 prep at,visualised
R6045 T8929 T8930 compound nucleotide,resolution
R6046 T8930 T8928 pobj resolution,at
R6047 T8931 T8918 prep on,visualised
R6048 T8932 T8933 det a,gel
R6049 T8933 T8931 pobj gel,on
R6050 T8934 T8933 amod denaturing,gel
R6051 T8935 T8933 compound polyacrylamide,gel
R6052 T8936 T8937 mark as,indicated
R6053 T8937 T8918 advcl indicated,visualised
R6054 T8938 T8918 punct .,visualised
R6055 T8941 T8942 det the,activity
R6056 T8942 T8940 dobj activity,Note
R6057 T8943 T8942 amod weak,activity
R6058 T8944 T8942 acl corresponding,activity
R6059 T8945 T8944 prep to,corresponding
R6060 T8946 T8947 det each,complex
R6061 T8947 T8945 pobj complex,to
R6062 T8948 T8947 amod single,complex
R6063 T8949 T8948 cc and,single
R6064 T8950 T8948 conj combined,single
R6065 T8951 T8947 compound TFIIH,complex
R6066 T8952 T8953 punct (,3
R6067 T8953 T8947 parataxis 3,complex
R6068 T8954 T8953 nmod lanes,3
R6069 T8955 T8956 punct –,8
R6070 T8956 T8953 prep 8,3
R6071 T8957 T8953 punct ),3
R6072 T8958 T8944 advcl relative,corresponding
R6073 T8959 T8958 prep to,relative
R6074 T8960 T8961 det the,wt
R6075 T8961 T8959 pobj wt,to
R6076 T8962 T8963 punct (,lane
R6077 T8963 T8961 parataxis lane,wt
R6078 T8964 T8963 nummod 1,lane
R6079 T8965 T8963 punct ),lane
R6080 T8966 T8961 cc and,wt
R6081 T8967 T8968 amod negative,controls
R6082 T8968 T8961 conj controls,wt
R6083 T8969 T8970 punct (,lane
R6084 T8970 T8968 parataxis lane,controls
R6085 T8971 T8970 nummod 2,lane
R6086 T8972 T8970 punct ),lane
R6087 T8973 T8940 punct .,Note
R6088 T8975 T8976 punct (,E
R6089 T8976 T8977 meta E,reduction
R6090 T8978 T8976 punct ),E
R6091 T8979 T8977 nmod Xpd,reduction
R6092 T8980 T8981 npadvmod dose,dependent
R6093 T8981 T8977 amod dependent,reduction
R6094 T8982 T8981 punct -,dependent
R6095 T8983 T8977 prep of,reduction
R6096 T8984 T8983 pobj TFIIH,of
R6097 T8985 T8977 prep in,reduction
R6098 T8986 T8987 amod homozygous,TTD
R6099 T8987 T8990 nmod TTD,cells
R6100 T8988 T8987 nmod XpdTTD,TTD
R6101 T8989 T8987 punct /,TTD
R6102 T8990 T8985 pobj cells,in
R6103 T8991 T8987 punct ", ",TTD
R6104 T8992 T8993 amod hemizygous,KO
R6105 T8993 T8987 conj KO,TTD
R6106 T8994 T8993 compound XpdTTD,KO
R6107 T8995 T8993 punct /,KO
R6108 T8996 T8993 punct ", ",KO
R6109 T8997 T8993 cc and,KO
R6110 T8998 T8999 nmod compound,†XPCS
R6111 T8999 T8993 conj †XPCS,KO
R6112 T9000 T8999 amod heterozygous,†XPCS
R6113 T9001 T8999 compound XpdTTD,†XPCS
R6114 T9002 T8999 punct /,†XPCS
R6115 T9003 T8999 cc and,†XPCS
R6116 T9004 T9005 compound XpdTTD,†XP
R6117 T9005 T8999 conj †XP,†XPCS
R6118 T9006 T9005 punct /,†XP
R6119 T9007 T8977 prep by,reduction
R6120 T9008 T9009 amod comparative,immunofluorescence
R6121 T9009 T9007 pobj immunofluorescence,by
R6122 T9010 T9009 prep of,immunofluorescence
R6123 T9011 T9012 det the,subunit
R6124 T9012 T9010 pobj subunit,of
R6125 T9013 T9012 compound p62,subunit
R6126 T9014 T9012 prep of,subunit
R6127 T9015 T9014 pobj TFIIH,of
R6128 T9016 T8977 punct .,reduction
R6129 T9018 T9019 amod Roman,numerals
R6130 T9019 T9020 nsubj numerals,represent
R6131 T9021 T9022 amod different,slides
R6132 T9022 T9020 dobj slides,represent
R6133 T9023 T9022 amod microscopic,slides
R6134 T9024 T9020 cc and,represent
R6135 T9025 T9026 amod Arabic,numerals
R6136 T9026 T9027 nsubj numerals,lines
R6137 T9027 T9020 conj lines,represent
R6138 T9028 T9027 amod different,lines
R6139 T9029 T9027 compound cell,lines
R6140 T9030 T9027 acl labelled,lines
R6141 T9031 T9032 mark as,follows
R6142 T9032 T9030 advcl follows,labelled
R6143 T9033 T9027 punct : ,lines
R6144 T9034 T9035 punct (,I
R6145 T9035 T9036 meta I,cells
R6146 T9036 T9027 dep cells,lines
R6147 T9037 T9035 punct ),I
R6148 T9038 T9036 compound wt,cells
R6149 T9039 T9040 punct (,1
R6150 T9040 T9036 parataxis 1,cells
R6151 T9041 T9040 punct ),1
R6152 T9042 T9036 acl labelled,cells
R6153 T9043 T9042 prep with,labelled
R6154 T9044 T9045 nummod 2,μm
R6155 T9045 T9047 compound μm,beads
R6156 T9046 T9045 punct -,μm
R6157 T9047 T9043 pobj beads,with
R6158 T9048 T9036 punct ", ",cells
R6159 T9049 T9050 compound XpdTTD,TTD
R6160 T9050 T9052 compound TTD,cells
R6161 T9051 T9050 punct /,TTD
R6162 T9052 T9036 conj cells,cells
R6163 T9053 T9054 punct (,2
R6164 T9054 T9052 parataxis 2,cells
R6165 T9055 T9054 punct ),2
R6166 T9056 T9052 prep with,cells
R6167 T9057 T9058 nummod 0.79,μm
R6168 T9058 T9060 compound μm,beads
R6169 T9059 T9058 punct -,μm
R6170 T9060 T9056 pobj beads,with
R6171 T9061 T9052 punct ", ",cells
R6172 T9062 T9052 cc and,cells
R6173 T9063 T9064 compound XpdTTD,KO
R6174 T9064 T9066 compound KO,cells
R6175 T9065 T9064 punct /,KO
R6176 T9066 T9052 conj cells,cells
R6177 T9067 T9068 punct (,3
R6178 T9068 T9066 parataxis 3,cells
R6179 T9069 T9068 punct ),3
R6180 T9070 T9066 prep with,cells
R6181 T9071 T9072 det no,beads
R6182 T9072 T9070 pobj beads,with
R6183 T9073 T9036 punct ;,cells
R6184 T9074 T9075 punct (,II
R6185 T9075 T9076 meta II,cells
R6186 T9076 T9036 conj cells,cells
R6187 T9077 T9075 punct ),II
R6188 T9078 T9076 compound wt,cells
R6189 T9079 T9080 punct (,1
R6190 T9080 T9076 parataxis 1,cells
R6191 T9081 T9080 punct ),1
R6192 T9082 T9076 acl labelled,cells
R6193 T9083 T9082 prep with,labelled
R6194 T9084 T9085 nummod 0.79,μm
R6195 T9085 T9087 compound μm,beads
R6196 T9086 T9085 punct -,μm
R6197 T9087 T9083 pobj beads,with
R6198 T9088 T9076 cc and,cells
R6199 T9089 T9090 compound XpdTTD,†XPCS
R6200 T9090 T9092 compound †XPCS,cells
R6201 T9091 T9090 punct /,†XPCS
R6202 T9092 T9076 conj cells,cells
R6203 T9093 T9094 punct (,4
R6204 T9094 T9092 parataxis 4,cells
R6205 T9095 T9094 punct ),4
R6206 T9096 T9092 prep with,cells
R6207 T9097 T9098 det no,beads
R6208 T9098 T9096 pobj beads,with
R6209 T9099 T9076 punct ;,cells
R6210 T9100 T9076 cc and,cells
R6211 T9101 T9102 punct (,III
R6212 T9102 T9103 meta III,cells
R6213 T9103 T9076 conj cells,cells
R6214 T9104 T9102 punct ),III
R6215 T9105 T9103 compound wt,cells
R6216 T9106 T9107 punct (,1
R6217 T9107 T9103 parataxis 1,cells
R6218 T9108 T9107 punct ),1
R6219 T9109 T9103 acl labelled,cells
R6220 T9110 T9109 prep with,labelled
R6221 T9111 T9112 nummod 0.79,μm
R6222 T9112 T9114 compound μm,beads
R6223 T9113 T9112 punct -,μm
R6224 T9114 T9110 pobj beads,with
R6225 T9115 T9103 cc and,cells
R6226 T9116 T9117 compound XpdTTD,†XP
R6227 T9117 T9119 compound †XP,cells
R6228 T9118 T9117 punct /,†XP
R6229 T9119 T9103 conj cells,cells
R6230 T9120 T9121 punct (,5
R6231 T9121 T9119 parataxis 5,cells
R6232 T9122 T9121 punct ),5
R6233 T9123 T9119 prep with,cells
R6234 T9124 T9125 det no,beads
R6235 T9125 T9123 pobj beads,with
R6236 T9126 T9027 punct .,lines
R6237 T9128 T9129 punct (,F
R6238 T9129 T9130 meta F,Quantification
R6239 T9131 T9129 punct ),F
R6240 T9132 T9130 prep of,Quantification
R6241 T9133 T9134 amod immunofluorescent,signal
R6242 T9134 T9132 pobj signal,of
R6243 T9135 T9134 prep from,signal
R6244 T9136 T9137 advmod at,50
R6245 T9137 T9139 nummod 50,nuclei
R6246 T9138 T9137 advmod least,50
R6247 T9139 T9135 pobj nuclei,from
R6248 T9140 T9139 prep per,nuclei
R6249 T9141 T9142 compound cell,line
R6250 T9142 T9140 pobj line,per
R6251 T9143 T9139 cc and,nuclei
R6252 T9144 T9145 quantmod 2,6
R6253 T9145 T9147 nummod 6,experiments
R6254 T9146 T9145 punct –,6
R6255 T9147 T9139 conj experiments,nuclei
R6256 T9148 T9147 prep per,experiments
R6257 T9149 T9148 pobj genotype,per
R6258 T9150 T9130 punct .,Quantification
R6259 T9152 T9153 nsubjpass Bars,depicted
R6260 T9154 T9152 acl representing,Bars
R6261 T9155 T9154 dobj cells,representing
R6262 T9156 T9155 acl analysed,cells
R6263 T9157 T9156 prep on,analysed
R6264 T9158 T9159 det the,slide
R6265 T9159 T9157 pobj slide,on
R6266 T9160 T9159 amod same,slide
R6267 T9161 T9159 amod microscopic,slide
R6268 T9162 T9153 auxpass are,depicted
R6269 T9163 T9153 npadvmod side,depicted
R6270 T9164 T9163 prep by,side
R6271 T9165 T9164 pobj side,by
R6272 T9166 T9153 punct ", ",depicted
R6273 T9167 T9153 prep with,depicted
R6274 T9168 T9167 pobj wt,with
R6275 T9169 T9168 acl set,wt
R6276 T9170 T9169 prep at,set
R6277 T9171 T9172 nummod 100,%
R6278 T9172 T9170 pobj %,at
R6279 T9173 T9153 punct .,depicted
R6280 T9175 T9176 det The,value
R6281 T9176 T9179 nsubj value,indicates
R6282 T9177 T9176 compound p,value
R6283 T9178 T9176 punct -,value
R6284 T9180 T9181 amod minimum,difference
R6285 T9181 T9179 dobj difference,indicates
R6286 T9182 T9181 amod significant,difference
R6287 T9183 T9181 prep between,difference
R6288 T9184 T9183 pobj wt,between
R6289 T9185 T9184 cc and,wt
R6290 T9186 T9187 det the,lines
R6291 T9187 T9184 conj lines,wt
R6292 T9188 T9187 amod indicated,lines
R6293 T9189 T9187 compound cell,lines
R6294 T9190 T9187 acl analysed,lines
R6295 T9191 T9190 prep on,analysed
R6296 T9192 T9193 det the,slide
R6297 T9193 T9191 pobj slide,on
R6298 T9194 T9193 amod same,slide
R6299 T9195 T9193 amod microscopic,slide
R6300 T9196 T9181 prep within,difference
R6301 T9197 T9198 nummod one,experiment
R6302 T9198 T9196 pobj experiment,within
R6303 T9199 T9179 punct .,indicates
R6304 T9212 T9211 prep of,Frequency
R6305 T9213 T9214 compound Xpd†XP,†XP
R6306 T9214 T9212 pobj †XP,of
R6307 T9215 T9214 punct /,†XP
R6308 T9216 T9214 punct ", ",†XP
R6309 T9217 T9218 compound Xpd†XPCS,†XPCS
R6310 T9218 T9214 conj †XPCS,†XP
R6311 T9219 T9218 punct /,†XPCS
R6312 T9220 T9218 punct ", ",†XPCS
R6313 T9221 T9218 cc and,†XPCS
R6314 T9222 T9223 nmod Compound,†XPCS
R6315 T9223 T9218 conj †XPCS,†XPCS
R6316 T9224 T9223 amod Heterozygous,†XPCS
R6317 T9225 T9223 compound Xpd†XP,†XPCS
R6318 T9226 T9223 punct /,†XPCS
R6319 T9227 T9214 appos Embryos,†XP
R6320 T9228 T9227 cc and,Embryos
R6321 T9229 T9227 conj Offspring,Embryos
R6322 T9241 T9242 amod Pleiotropic,Effects
R6323 T9243 T9242 nmod Xpd,Effects
R6324 T9244 T9242 amod Biallelic,Effects
R6325 T9245 T9242 prep in,Effects
R6326 T9246 T9245 pobj Mice,in
R6327 T9247 T9246 cc and,Mice
R6328 T9248 T9246 conj Cells,Mice
R6329 T9280 T9281 compound Genotype,Phenotype
R6330 T9281 T9283 compound Phenotype,Relationships
R6331 T9282 T9281 punct –,Phenotype
R6332 T9284 T9283 prep in,Relationships
R6333 T9285 T9286 compound XPD,Disorders
R6334 T9286 T9284 pobj Disorders,in
R6335 T9288 T9289 prep According,determined
R6336 T9290 T9288 prep to,According
R6337 T9291 T9292 det the,hypothesis
R6338 T9292 T9290 pobj hypothesis,to
R6339 T9293 T9292 amod current,hypothesis
R6340 T9294 T9292 amod monoallelic,hypothesis
R6341 T9295 T9289 punct ", ",determined
R6342 T9296 T9289 nsubjpass phenotype,determined
R6343 T9297 T9289 auxpass is,determined
R6344 T9298 T9299 advmod solely,by
R6345 T9299 T9289 agent by,determined
R6346 T9300 T9301 det the,product
R6347 T9301 T9299 pobj product,by
R6348 T9302 T9301 amod causative,product
R6349 T9303 T9301 compound allele,product
R6350 T9304 T9289 punct .,determined
R6351 T9306 T9307 mark If,is
R6352 T9307 T9313 advcl is,considered
R6353 T9308 T9309 det a,allele
R6354 T9309 T9307 nsubj allele,is
R6355 T9310 T9309 amod second,allele
R6356 T9311 T9309 punct ", ",allele
R6357 T9312 T9309 amod different,allele
R6358 T9314 T9307 acomp present,is
R6359 T9315 T9313 punct ", ",considered
R6360 T9316 T9313 nsubjpass it,considered
R6361 T9317 T9313 auxpass is,considered
R6362 T9318 T9319 det a,null
R6363 T9319 T9313 oprd null,considered
R6364 T9320 T9319 amod functional,null
R6365 T9321 T9313 punct .,considered
R6366 T9323 T9324 expl There,is
R6367 T9325 T9326 det a,lack
R6368 T9326 T9324 attr lack,is
R6369 T9327 T9326 prep of,lack
R6370 T9328 T9329 det any,correlation
R6371 T9329 T9327 pobj correlation,of
R6372 T9330 T9329 prep between,correlation
R6373 T9331 T9332 det the,site
R6374 T9332 T9330 pobj site,between
R6375 T9333 T9332 prep of,site
R6376 T9334 T9335 det the,mutation
R6377 T9335 T9333 pobj mutation,of
R6378 T9336 T9335 compound XPD,mutation
R6379 T9337 T9332 cc and,site
R6380 T9338 T9339 det the,disorder
R6381 T9339 T9332 conj disorder,site
R6382 T9340 T9339 amod resulting,disorder
R6383 T9341 T9324 punct .,is
R6384 T9343 T9344 nsubj We,propose
R6385 T9345 T9346 det a,hypothesis
R6386 T9346 T9344 dobj hypothesis,propose
R6387 T9347 T9346 amod biallelic,hypothesis
R6388 T9348 T9346 prep for,hypothesis
R6389 T9349 T9350 compound compound,heterozygotes
R6390 T9350 T9348 pobj heterozygotes,for
R6391 T9351 T9352 prep in,contribute
R6392 T9352 T9346 relcl contribute,hypothesis
R6393 T9353 T9351 pobj which,in
R6394 T9354 T9355 det both,alleles
R6395 T9355 T9352 nsubj alleles,contribute
R6396 T9356 T9352 aux can,contribute
R6397 T9357 T9352 prep to,contribute
R6398 T9358 T9359 det the,phenotype
R6399 T9359 T9357 pobj phenotype,to
R6400 T9360 T9344 punct .,propose
R6401 T9362 T9363 nsubjpass Examples,provided
R6402 T9364 T9362 prep of,Examples
R6403 T9365 T9366 nmod compound,patients
R6404 T9366 T9364 pobj patients,of
R6405 T9367 T9366 amod heterozygous,patients
R6406 T9368 T9369 prep in,is
R6407 T9369 T9366 relcl is,patients
R6408 T9370 T9368 pobj which,in
R6409 T9371 T9372 det a,allele
R6410 T9372 T9369 nsubj allele,is
R6411 T9373 T9372 amod second,allele
R6412 T9374 T9372 punct ", ",allele
R6413 T9375 T9376 amod presumed,null
R6414 T9376 T9372 amod null,allele
R6415 T9377 T9369 acomp likely,is
R6416 T9378 T9379 aux to,contribute
R6417 T9379 T9377 xcomp contribute,likely
R6418 T9380 T9379 prep to,contribute
R6419 T9381 T9382 compound disease,outcome
R6420 T9382 T9380 pobj outcome,to
R6421 T9383 T9363 auxpass are,provided
R6422 T9384 T9363 advmod above,provided
R6423 T9385 T9363 prep in,provided
R6424 T9386 T9385 pobj comparison,in
R6425 T9387 T9386 prep to,comparison
R6426 T9388 T9389 amod corresponding,patients
R6427 T9389 T9387 pobj patients,to
R6428 T9390 T9391 advmod homo,hemizygous
R6429 T9391 T9389 amod hemizygous,patients
R6430 T9392 T9391 punct -,hemizygous
R6431 T9393 T9391 cc or,hemizygous
R6432 T9394 T9389 prep with,patients
R6433 T9395 T9396 det the,allele
R6434 T9396 T9394 pobj allele,with
R6435 T9397 T9396 amod same,allele
R6436 T9398 T9396 amod causative,allele
R6437 T9399 T9363 punct .,provided
R6438 T9401 T9402 nsubj Numbers,indicate
R6439 T9403 T9401 prep in,Numbers
R6440 T9404 T9405 det the,schematic
R6441 T9405 T9403 pobj schematic,in
R6442 T9406 T9405 prep of,schematic
R6443 T9407 T9408 det the,protein
R6444 T9408 T9406 pobj protein,of
R6445 T9409 T9410 det the,domains
R6446 T9410 T9402 dobj domains,indicate
R6447 T9411 T9410 compound helicase,domains
R6448 T9412 T9402 punct .,indicate
R34 T121 T122 poss its,potential
R1 T86 T84 prep of,Rescue
R2 T87 T86 pobj Progeria,of
R3 T88 T84 prep in,Rescue
R4 T89 T88 pobj Trichothiodystrophy,in
R5 T90 T84 prep by,Rescue
R6 T91 T92 amod Homozygous,Alleles
R10 T96 T97 mark Although,is
R25 T111 T109 pobj gene,of
R28 T115 T97 acomp common,is
R29 T116 T97 prep in,is
R30 T117 T118 amod human,disease
R33 T120 T114 punct ", ",documented
R35 T122 T114 nsubjpass potential,documented
R36 T123 T124 aux to,impact
R37 T124 T122 acl impact,potential
R38 T125 T126 compound disease,outcome
R39 T126 T124 dobj outcome,impact
R40 T127 T114 aux has,documented
R41 T128 T114 neg not,documented
R42 T129 T114 auxpass been,documented
R43 T130 T114 advmod well,documented
R44 T131 T114 punct .,documented
R45 T133 T134 nsubj This,is
R46 T135 T136 advmod most,likely
R47 T136 T137 advmod likely,because
R48 T137 T134 prep because,is
R49 T138 T137 pcomp of,because
R50 T139 T140 det the,difficulty
R53 T142 T140 prep in,difficulty
R54 T143 T142 pcomp distinguishing,in
R55 T144 T145 amod specific,effects
R58 T147 T143 prep from,distinguishing
R59 T148 T147 pobj differences,from
R60 T149 T148 prep in,differences
R61 T150 T149 pobj environment,in
R62 T151 T150 cc or,environment
R63 T152 T153 amod genetic,background
R64 T153 T150 conj background,environment
R65 T154 T134 punct .,is
R66 T156 T157 nsubj We,addressed
R67 T158 T159 det the,potential
R68 T159 T157 dobj potential,addressed
R69 T160 T159 prep of,potential
R70 T161 T162 amod different,alleles
R73 T164 T165 aux to,contribute
R74 T165 T159 acl contribute,potential
R75 T166 T165 prep to,contribute
R76 T167 T168 det the,pleiotropy
R79 T170 T168 acl associated,pleiotropy
R80 T171 T170 prep with,associated
R81 T172 T173 nmod XPD,disorders
R84 T175 T170 prep in,associated
R85 T176 T177 nmod compound,models
R89 T180 T157 punct .,addressed
R90 T182 T183 nsubj Alterations,result
R91 T184 T182 prep in,Alterations
R92 T185 T186 det this,helicase
R95 T188 T186 punct ", ",helicase
R96 T189 T186 prep with,helicase
R97 T190 T189 pobj functions,with
R98 T191 T190 prep in,functions
R99 T192 T193 preconj both,repair
R102 T195 T193 cc and,repair
R103 T196 T197 amod basal,transcription
R104 T197 T193 conj transcription,repair
R105 T198 T183 punct ", ",result
R106 T199 T183 prep in,result
R107 T200 T201 amod diverse,pathologies
R108 T201 T199 pobj pathologies,in
R109 T202 T201 acl ranging,pathologies
R110 T203 T202 prep from,ranging
R111 T204 T205 amod elevated,sensitivity
R114 T207 T205 cc and,sensitivity
R115 T208 T209 compound cancer,predisposition
R116 T209 T205 conj predisposition,sensitivity
R117 T210 T203 prep to,from
R118 T211 T212 amod accelerated,progeria
R121 T214 T183 punct .,result
R122 T216 T217 nsubj We,report
R123 T218 T219 det a,variety
R124 T219 T217 dobj variety,report
R125 T220 T219 prep of,variety
R126 T221 T222 amod biallelic,effects
R127 T222 T220 pobj effects,of
R128 T223 T222 prep on,effects
R129 T224 T225 amod organismal,phenotype
R130 T225 T223 pobj phenotype,on
R131 T226 T222 amod attributable,effects
R132 T227 T226 prep to,attributable
R133 T228 T227 pobj combinations,to
R134 T229 T228 prep of,combinations
R135 T230 T231 amod recessive,alleles
R138 T233 T219 punct ", ",variety
R139 T234 T219 prep including,variety
R140 T235 T236 det the,following
R141 T236 T234 pobj following,including
R142 T237 T236 punct : ,following
R143 T238 T239 punct (,i
R144 T239 T240 meta i,ability
R148 T243 T240 prep of,ability
R149 T244 T245 amod homozygous,alleles
R153 T248 T249 aux to,ameliorate
R154 T249 T240 acl ameliorate,ability
R155 T250 T251 det a,variety
R156 T251 T249 dobj variety,ameliorate
R157 T252 T251 prep of,variety
R158 T253 T254 compound disease,symptoms
R159 T254 T252 pobj symptoms,of
R160 T255 T256 advmod when,supplied
R168 T263 T256 agent by,supplied
R169 T264 T265 det a,allele
R173 T268 T265 amod causing,allele
R175 T270 T240 punct ", ",ability
R176 T271 T272 punct (,ii
R177 T272 T273 meta ii,functions
R184 T279 T276 conj specific,developmental
R186 T281 T273 prep of,functions
R187 T282 T283 amod distinct,products
R191 T286 T273 punct ", ",functions
R192 T287 T273 cc and,functions
R193 T288 T289 punct (,iii
R194 T289 T290 meta iii,complementation
R198 T293 T290 punct ", ",complementation
R199 T294 T295 det a,phenomenon
R200 T295 T290 appos phenomenon,complementation
R201 T296 T297 advmod rarely,reported
R202 T297 T295 acl reported,phenomenon
R203 T298 T297 prep at,reported
R204 T299 T300 advmod clinically,relevant
R205 T300 T301 amod relevant,loci
R206 T301 T298 pobj loci,at
R207 T302 T301 prep in,loci
R208 T303 T302 pobj mammals,in
R209 T304 T217 punct .,report
R210 T306 T307 poss Our,data
R211 T307 T308 nsubj data,suggest
R212 T309 T310 det a,re-evaluation
R213 T310 T308 dobj re-evaluation,suggest
R214 T311 T310 prep of,re-evaluation
R215 T312 T313 det the,contribution
R216 T313 T311 pobj contribution,of
R217 T314 T313 prep of,contribution
R218 T315 T314 punct “,of
R219 T316 T317 amod null,alleles
R222 T319 T313 prep to,contribution
R223 T320 T321 compound XPD,disorders
R224 T321 T319 pobj disorders,to
R225 T322 T308 cc and,suggest
R226 T323 T308 conj highlight,suggest
R227 T324 T325 det the,potential
R228 T325 T323 dobj potential,highlight
R229 T326 T325 prep of,potential
R230 T327 T326 pobj combinations,of
R231 T328 T327 prep of,combinations
R232 T329 T330 amod recessive,alleles
R233 T330 T328 pobj alleles,of
R234 T331 T332 aux to,affect
R235 T332 T325 acl affect,potential
R236 T333 T334 preconj both,plasticity
R242 T339 T332 prep in,affect
R243 T340 T339 pobj mammals,in
R244 T341 T308 punct .,suggest
R912 T1403 T1401 pobj Heterozygotes,of
R923 T1416 T1414 pobj mutation,with
R937 T1430 T1428 pobj patient,in
R941 T1434 T1407 parataxis 1A,generated
R951 T1446 T1444 pobj allele,from
R957 T1452 T1450 pobj cells,in
R961 T1456 T1454 pobj PCR,by
R964 T1459 T1443 parataxis 1D,detected
R996 T1491 T1443 parataxis 1E,detected
R1008 T1505 T1503 pobj protein,with
R1016 T1513 T1511 pobj allele,from
R1020 T1517 T1500 nsubjpass mutation,expected
R1028 T1525 T1523 pobj state,in
R1034 T1533 T1530 nsubjpass mice,observed
R1077 T1580 T1578 pobj allele,of
R1088 T1591 T1589 pobj protein,of
R1097 T1600 T1598 parataxis 1A,targeting
R1120 T1625 T1623 pobj stages,beyond
R1142 T1649 T1646 relcl associated,XPDR683W
R1148 T1655 T1653 pobj state,in
R1159 T1666 T1664 pobj state,in
R1168 T1675 T1635 parataxis 1A,was
R1200 T1709 T1707 pobj gene,of
R1206 T1715 T1713 pobj levels,of
R1216 T1725 T1722 parataxis G602D,XPCS
R1860 T2739 T2733 ccomp rescued,revealed
R1861 T2740 T2741 npadvmod TTD,associated
R1862 T2741 T2743 amod associated,cachexia
R1863 T2742 T2741 punct -,associated
R1864 T2743 T2739 nsubjpass cachexia,rescued
R1865 T2744 T2745 npadvmod age,related
R1866 T2745 T2743 amod related,cachexia
R1867 T2746 T2745 punct -,related
R1868 T2747 T2743 amod premature,cachexia
R1869 T2748 T2743 cc and,cachexia
R1870 T2749 T2743 conj lack,cachexia
R1871 T2750 T2749 prep of,lack
R1872 T2751 T2752 amod general,fitness
R1873 T2752 T2750 pobj fitness,of
R1874 T2753 T2739 auxpass were,rescued
R1875 T2754 T2739 advmod fully,rescued
R1876 T2755 T2739 prep in,rescued
R1877 T2756 T2757 amod compound,mice
R1878 T2757 T2755 pobj mice,in
R1879 T2758 T2757 amod heterozygous,mice
R1880 T2759 T2760 compound XpdTTD,†XPCS
R1881 T2760 T2757 compound †XPCS,mice
R1882 T2761 T2760 punct /,†XPCS
R1883 T2762 T2763 punct (,3A
R1884 T2763 T2733 parataxis 3A,revealed
R1885 T2764 T2763 compound Figure,3A
R1886 T2765 T2763 cc and,3A
R1887 T2766 T2763 conj 3D,3A
R1888 T2767 T2763 punct ),3A
R1889 T2768 T2733 punct .,revealed
R1890 T2770 T2771 advmod Finally,extended
R1910 T2792 T2793 aux To,determine
R1911 T2793 T2794 advcl determine,generated
R1912 T2795 T2796 mark whether,was
R1913 T2796 T2793 ccomp was,determine
R1914 T2797 T2798 det the,allele
R1915 T2798 T2796 nsubj allele,was
R1916 T2799 T2798 amod homozygous,allele
R1917 T2800 T2798 amod lethal,allele
R1918 T2801 T2798 compound Xpd†XPCS,allele
R1919 T2802 T2796 acomp unique,was
R1920 T2803 T2802 prep in,unique
R1921 T2804 T2805 poss its,ability
R1922 T2805 T2803 pobj ability,in
R1556 T2301 T2299 pobj level,below
R1558 T2303 T2304 punct (,2C
R1559 T2304 T2274 parataxis 2C,confirmed
R1560 T2305 T2304 compound Figure,2C
R1561 T2306 T2304 punct ),2C
R1562 T2307 T2274 punct .,confirmed
R1563 T2309 T2310 compound TTD,hemizygotes
R1564 T2310 T2311 nsubj hemizygotes,display
R1565 T2312 T2313 punct (,KO
R1566 T2313 T2310 parataxis KO,hemizygotes
R1567 T2314 T2313 compound XpdTTD,KO
R1568 T2315 T2313 punct /,KO
R1569 T2316 T2313 punct ),KO
R1570 T2317 T2311 aux do,display
R1571 T2318 T2311 neg not,display
R1572 T2319 T2320 amod significant,differences
R1573 T2320 T2311 dobj differences,display
R1574 T2321 T2320 prep in,differences
R1575 T2322 T2323 amod cutaneous,features
R1576 T2323 T2321 pobj features,in
R1577 T2324 T2323 cc and,features
R1578 T2325 T2323 conj longevity,features
R1579 T2326 T2320 amod relative,differences
R1580 T2327 T2326 prep to,relative
R1581 T2328 T2329 amod homozygous,mice
R1582 T2329 T2327 pobj mice,to
R1583 T2330 T2331 compound XpdTTD,TTD
R1584 T2331 T2329 compound TTD,mice
R1585 T2332 T2331 punct /,TTD
R1586 T2333 T2334 punct [,21
R1587 T2334 T2311 parataxis 21,display
R1588 T2335 T2334 punct ],21
R1589 T2336 T2311 punct .,display
R1590 T2338 T2339 amod Other,features
R1591 T2339 T2342 nsubj features,were
R1592 T2340 T2339 amod prominent,features
R1593 T2341 T2339 compound TTD,features
R1594 T2343 T2339 prep in,features
R1595 T2344 T2345 det the,epidermis
R1596 T2345 T2343 pobj epidermis,in
R1597 T2346 T2339 punct ", ",features
R1598 T2347 T2339 prep including,features
R1599 T2348 T2347 pobj acanthosis,including
R1600 T2349 T2350 punct (,thickening
R1601 T2350 T2348 parataxis thickening,acanthosis
R1602 T2351 T2350 prep of,thickening
R1603 T2352 T2353 det the,layer
R1604 T2353 T2351 pobj layer,of
R1605 T2354 T2353 prep of,layer
R1606 T2355 T2356 det the,cells
R1607 T2356 T2354 pobj cells,of
R1608 T2357 T2356 amod nucleated,cells
R1609 T2358 T2350 punct ),thickening
R1610 T2359 T2348 punct ", ",acanthosis
R1611 T2360 T2348 conj hyperkeratosis,acanthosis
R1612 T2361 T2362 punct (,thickening
R1613 T2362 T2360 parataxis thickening,hyperkeratosis
R1614 T2363 T2362 amod prominent,thickening
R1615 T2364 T2362 prep of,thickening
R1616 T2365 T2366 det the,layer
R1617 T2366 T2364 pobj layer,of
R1618 T2367 T2366 amod cornified,layer
R1619 T2368 T2362 punct ),thickening
R1620 T2369 T2360 punct ", ",hyperkeratosis
R1621 T2370 T2360 cc and,hyperkeratosis
R1622 T2371 T2372 amod pronounced,layer
R1623 T2372 T2360 conj layer,hyperkeratosis
R1624 T2373 T2372 amod granular,layer
R262 T582 T578 advcl can,function
R270 T592 T589 pobj universality,Despite
R320 T644 T646 compound CoA,carboxylase
R345 T669 T662 conj mutase,uridylyltransferase
R361 T687 T685 pobj gene,of
R392 T720 T717 pobj effects,as
R398 T726 T724 pobj outcomes,in
R415 T745 T734 dobj bias,create
R430 T760 T757 conj effects,complementation
R485 T817 T815 pobj initiation,including
R489 T821 T817 conj repair,initiation
R512 T846 T844 pobj function,in
R517 T851 T853 amod sensitive,disorders
R553 T889 T891 amod induced,anomalies
R555 T891 T887 pobj anomalies,by
R590 T930 T928 pobj hand,on
R594 T934 T924 attr disorders,are
R649 T991 T989 pobj types,in
R658 T1001 T1003 nsubjpass disorder,described
R662 T1006 T1004 pobj predisposition,with
R669 T1013 T1011 pobj complications,with
R688 T1033 T1035 nsubjpass mutations,associated
R709 T1055 T1035 conj viewed,associated
R715 T1061 T1059 pobj syndromes,of
R753 T1103 T1101 pobj mutation,with
R762 T1112 T1087 conj considered,fail
R767 T1117 T1115 pobj activity,of
R784 T1136 T1126 ccomp refer,defines
R812 T1166 T1164 pobj presentation,with
R856 T1212 T1210 dobj syndrome,phenocopies
R885 T1243 T1245 amod associated,ageing
R2439 T3689 T3688 prep of,none
R2440 T3690 T3691 det the,combinations
R2518 T3778 T3779 nsubj sk,e
R2519 T3779 T3780 ccomp e,t
R2520 T3781 T3779 dobj d,e
R2521 T3782 T3781 prep wh,d
R2522 T3783 T3780 nsubj e,t
R2523 T3789 T3790 det h,e
R2524 T3798 T3797 cc and,†XPCS
R2525 T3799 T3800 compound Xpd,†XP
R2526 T3800 T3797 conj †XP,†XPCS
R2527 T3801 T3802 amod a,l
R2528 T3804 T3805 nsubj l,e
R2529 T3806 T3805 dobj les,e
R2530 T3812 T3811 pobj e,it
R2531 T3817 T3818 amod re,a
R2532 T3821 T3820 cc d,e
R2533 T3822 T3820 conj m,e
R2534 T3826 T3825 compound RNA,levels
R2535 T3827 T3824 punct ", ",ameliorated
R2536 T3828 T3829 compound TTD,symptoms
R2537 T3829 T3824 dobj symptoms,ameliorated
R2538 T3830 T3824 prep by,ameliorated
R2539 T3831 T3832 amod increasing,levels
R2540 T3832 T3830 pobj levels,by
R2541 T3833 T3832 amod overall,levels
R2542 T3834 T3832 compound TFIIH,levels
R2543 T3835 T3824 prep in,ameliorated
R2544 T3836 T3837 nmod compound,cells
R2545 T3837 T3835 pobj cells,in
R2546 T3838 T3837 amod heterozygous,cells
R2547 T3839 T3840 nmod XpdTTD, †XPCS
R2548 T3840 T3837 nmod  †XPCS,cells
R2549 T3841 T3840 punct /, †XPCS
R2550 T3842 T3840 cc and, †XPCS
R2551 T3843 T3844 compound XpdTTD, †XP
R2552 T3844 T3840 conj  †XP, †XPCS
R2553 T3845 T3844 punct /, †XP
R2554 T3848 T3849 advmod Previously,shown
R2555 T3850 T3849 punct ", ",shown
R2556 T3851 T3849 advcl using,shown
R2557 T3852 T3853 amod comparative,immunohistochemistry
R2558 T3853 T3851 dobj immunohistochemistry,using
R2559 T3854 T3849 punct ", ",shown
R2560 T3855 T3849 nsubj we,shown
R2561 T3856 T3855 cc and,we
R2562 T3857 T3855 conj others,we
R2563 T3858 T3849 aux have,shown
R2564 T3859 T3860 det an,reduction
R2565 T3860 T3849 dobj reduction,shown
R2566 T3861 T3862 quantmod up,70
R2567 T3862 T3864 nummod 70,%
R2568 T3863 T3862 quantmod to,70
R2569 T3864 T3860 compound %,reduction
R2570 T3865 T3860 prep of,reduction
R2571 T3866 T3867 compound TFIIH,levels
R2812 T4119 T4120 amod normal,levels
R2813 T4120 T4118 pobj levels,with
R2814 T4121 T4120 compound expression,levels
R2815 T4122 T4120 prep from,levels
R2816 T4123 T4124 det the,allele
R2817 T4124 T4122 pobj allele,from
R2818 T4125 T4124 amod viable,allele
R2819 T4126 T4124 compound XpdXPCS,allele
R2820 T4127 T4128 punct (,Table
R2821 T4128 T4088 parataxis Table,had
R2822 T4129 T4128 nummod 2,Table
R2823 T4130 T4128 cc and,Table
R2824 T4131 T4132 amod unpublished,data
R2825 T4132 T4128 conj data,Table
R2826 T4133 T4128 punct ),Table

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T20 63-66 PR:000007164 denotes Xpd
T21 67-74 SO:0001023 denotes Alleles
T22 199-206 SO:0001023 denotes alleles
T23 219-223 SO:0000704 denotes gene
T24 238-243 NCBITaxon:9606 denotes human
T25 417-424 SO:0001023 denotes allelic
T26 468-475 SO:0000704 denotes genetic
T27 538-545 SO:0001023 denotes alleles
T28 604-607 PR:000007164 denotes XPD
T29 653-658 NCBITaxon:10088 denotes mouse
T30 730-740 GO:0006281 denotes DNA repair
T31 919-926 SO:0001023 denotes allelic
T32 938-948 NCBITaxon:1 denotes organismal
T33 1001-1004 PR:000007164 denotes Xpd
T34 1005-1012 SO:0001023 denotes alleles
T35 1076-1079 PR:000007164 denotes Xpd
T36 1080-1087 SO:0001023 denotes alleles
T37 1225-1231 SO:0001023 denotes allele
T38 1269-1275 UBERON:0000479 denotes tissue
T39 1307-1310 PR:000007164 denotes Xpd
T40 1311-1317 SO:0001023 denotes allele
T41 1343-1350 SO:0001023 denotes allelic
T42 1428-1435 NCBITaxon:40674 denotes mammals
T43 1500-1507 SO:0001023 denotes alleles
T44 1511-1514 PR:000007164 denotes XPD
T45 1582-1589 SO:0001023 denotes alleles
T46 1654-1661 NCBITaxon:40674 denotes mammals
T406 1905-1912 SO:0001023 denotes allelic
T407 1985-1992 SO:0001023 denotes alleles
T408 2088-2097 NCBITaxon:1 denotes organisms
T409 2160-2165 NCBITaxon:9606 denotes human
T410 2213-2220 SO:0001023 denotes allelic
T411 2330-2339 GO:0008152 denotes metabolic
T412 2384-2396 CHEBI:15539 denotes propinyl-CoA
T413 2414-2431 CHEBI:57472 denotes argininosuccinate
T414 2443-2464 CHEBI:53025 denotes galactose-1-phosphate
T415 2494-2511 CHEBI:16625 denotes methylmalonyl CoA
T416 2551-2562 NCBITaxon:1 denotes individuals
T417 2593-2600 SO:0001023 denotes alleles
T418 2613-2617 SO:0000704 denotes gene
T419 2665-2671 SO:0001023 denotes allele
T420 2673-2680 SO:0000704 denotes genetic
T421 2712-2719 SO:0001023 denotes alleles
T422 2744-2751 SO:0001023 denotes allelic
T423 2823-2830 SO:0001023 denotes allelic
T424 2898-2905 SO:0001023 denotes allelic
T425 3009-3016 SO:0001023 denotes allelic
T426 3044-3051 SO:0001023 denotes allelic
T427 3063-3068 NCBITaxon:9606 denotes human
T428 3164-3171 SO:0000704 denotes genetic
T429 3184-3187 PR:000007164 denotes XPD
T430 3234-3275 GO:0005675 denotes basal transcription/DNA repair factor IIH
T431 3254-3264 GO:0006281 denotes DNA repair
T432 3277-3282 GO:0005675 denotes TFIIH
T433 3316-3323 GO:0032991 denotes complex
T434 3411-3428 GO:0006281 denotes DNA damage repair
T435 3437-3463 GO:0006289 denotes nucleotide excision repair
T436 3465-3468 GO:0006289 denotes NER
T437 3500-3503 PR:000007164 denotes XPD
T438 3527-3532 GO:0005675 denotes TFIIH
T439 3581-3587 UBERON:0000467 denotes system
T440 4016-4021 GO:0007567 denotes natal
T441 4226-4230 UBERON:0001037 denotes hair
T442 4235-4240 UBERON:0001705 denotes nails
T443 4414-4432 GO:0007399 denotes neurodevelopmental
T444 4511-4514 PR:000007164 denotes XPD
T445 4583-4586 PR:000007164 denotes XPD
T446 4605-4608 PR:000007164 denotes XPD
T447 4688-4695 SO:0001023 denotes Alleles
T448 4770-4777 SO:0001023 denotes alleles
T449 4801-4808 SO:0001023 denotes alleles
T450 4848-4879 NCBITaxon:4896 denotes Schizosaccharomyces pombe yeast
T451 4915-4918 PR:000007164 denotes XPD
T452 4919-4928 SO:0000853 denotes homologue
T453 4929-4934 PR:P26659 denotes rad15
T454 5030-5037 SO:0001023 denotes alleles
T455 5111-5118 SO:0001023 denotes allelic
T456 5132-5135 PR:000007164 denotes XPD
T457 5348-5355 SO:0001023 denotes allelic
T458 5457-5462 NCBITaxon:10088 denotes mouse
T459 5470-5473 PR:000007164 denotes XPD
T460 5501-5506 NCBITaxon:9606 denotes human
T461 5576-5579 PR:000007164 denotes Xpd
T462 5580-5587 SO:0001023 denotes alleles
T463 5695-5701 GO:0007568 denotes ageing
T464 5732-5742 GO:0006281 denotes DNA repair
T1302 5840-5843 PR:000007164 denotes Xpd
T1303 5883-5886 PR:000007164 denotes Xpd
T1304 5896-5902 SO:0001023 denotes allele
T1305 5962-5965 PR:000007164 denotes XPD
T1306 6025-6035 GO:0010467 denotes expression
T1307 6054-6060 SO:0001023 denotes allele
T1308 6082-6091 UBERON:0000922 denotes embryonic
T1309 6082-6102 CL:0002322 denotes embryonic stem cells
T1310 6135-6145 GO:0010467 denotes expression
T1311 6268-6274 UBERON:0000473 denotes testis
T1312 6291-6298 NCBITaxon:33208 denotes animals
T1313 6363-6366 PR:000007164 denotes XPD
T1314 6376-6379 PR:000007164 denotes XPD
T1315 6386-6395 GO:0010467 denotes expressed
T1316 6410-6416 SO:0001023 denotes allele
T1317 6523-6527 NCBITaxon:10088 denotes mice
T1318 6579-6588 UBERON:0000922 denotes embryonic
T1319 6614-6621 UBERON:0000922 denotes embryos
T1320 6671-6677 SO:0001023 denotes allele
T1321 6761-6767 SO:0001023 denotes allele
T1322 6803-6813 GO:0010467 denotes expression
T1323 6855-6859 SO:0000704 denotes gene
T1324 6918-6921 PR:000007164 denotes Xpd
T1325 6932-6935 PR:000007164 denotes Xpd
T1326 6975-6979 UBERON:0000104 denotes life
T1780 9852-9858 SO:0001023 denotes Allele
T1781 9904-9908 UBERON:0001037 denotes Hair
T1782 9977-9983 SO:0001023 denotes allele
T1783 10014-10024 NCBITaxon:1 denotes organismal
T1784 10051-10054 PR:000007164 denotes Xpd
T1785 10060-10066 SO:0001023 denotes allele
T1786 10081-10084 PR:000007164 denotes Xpd
T1787 10088-10094 SO:0001023 denotes allele
T1788 10138-10145 NCBITaxon:33208 denotes animals
T1789 10173-10177 NCBITaxon:10088 denotes mice
T1790 10196-10199 PR:000007164 denotes Xpd
T1791 10209-10215 SO:0001023 denotes allele
T1792 10217-10220 PR:000007164 denotes Xpd
T1793 10251-10254 PR:000007164 denotes Xpd
T1794 10264-10268 NCBITaxon:10088 denotes mice
T1795 10274-10278 GO:0007567 denotes born
T1796 10318-10328 GO:0010467 denotes Expression
T1797 10338-10341 PR:000007164 denotes Xpd
T1798 10347-10353 SO:0001023 denotes allele
T1799 10378-10384 UBERON:0000473 denotes testis
T1800 10410-10417 NCBITaxon:33208 denotes animals
T1801 10427-10437 GO:0010467 denotes expression
T1802 10447-10450 PR:000007164 denotes Xpd
T1803 10454-10460 SO:0001023 denotes allele
T1804 10545-10555 GO:0042571 denotes antibodies
T1805 10621-10624 PR:000007164 denotes XPD
T1806 10727-10730 PR:000007164 denotes XPD
T1807 10758-10765 SO:0001023 denotes alleles
T1808 10798-10808 GO:0010467 denotes expression
T1809 10832-10835 PR:000007164 denotes Xpd
T1810 10841-10847 SO:0001023 denotes allele
T1811 10869-10872 PR:000007164 denotes Xpd
T1812 10929-10932 PR:000007164 denotes Xpd
T1813 10942-10949 NCBITaxon:33208 denotes animals
T1814 10981-10985 UBERON:0001037 denotes hair
T1815 11053-11057 NCBITaxon:10088 denotes mice
T1816 11096-11099 PR:000007164 denotes Xpd
T1817 11112-11115 PR:000007164 denotes Xpd
T1818 11123-11127 NCBITaxon:10088 denotes mice
T1819 11152-11156 UBERON:0001037 denotes hair
T1820 11175-11179 UBERON:0001037 denotes hair
T1821 11175-11185 GO:0042633 denotes hair cycle
T1822 11198-11202 UBERON:0001037 denotes hair
T1823 11246-11251 UBERON:0000104 denotes lives
T1824 11280-11283 PR:000007164 denotes Xpd
T1825 11293-11297 NCBITaxon:10088 denotes mice
T1826 11313-11317 UBERON:0001037 denotes hair
T1827 11345-11349 UBERON:0001037 denotes hair
T1828 11345-11355 GO:0042633 denotes hair cycle
T1829 11380-11384 UBERON:0001137 denotes back
T1830 11407-11415 CHEBI:10545 denotes electron
T1831 11439-11442 PR:000007164 denotes Xpd
T1832 11452-11456 UBERON:0001037 denotes hair
T1833 11533-11538 UBERON:0001037 denotes hairs
T1834 11650-11654 UBERON:0001037 denotes hair
T1835 11662-11665 PR:000007164 denotes Xpd
T1836 11675-11679 NCBITaxon:10088 denotes mice
T1837 11714-11717 PR:000007164 denotes Xpd
T2493 14429-14436 NCBITaxon:33208 denotes animals
T2494 14490-14493 PR:000007164 denotes Xpd
T2495 14503-14507 NCBITaxon:10088 denotes mice
T2496 14703-14706 PR:000007164 denotes Xpd
T2497 14716-14720 NCBITaxon:10088 denotes mice
T2498 14754-14763 UBERON:0000104 denotes life span
T2499 14815-14818 PR:000007164 denotes Xpd
T2500 14826-14830 NCBITaxon:10088 denotes mice
T2511 16515-16521 SO:0001023 denotes allele
T2512 16559-16563 UBERON:0001037 denotes hair
T2513 16733-16739 GO:0007568 denotes ageing
T2514 16877-16886 UBERON:0000104 denotes life span
T2515 16955-16962 SO:0001023 denotes alleles
T3067 17134-17141 SO:0001023 denotes allelic
T3068 17215-17228 GO:0071897 denotes DNA synthesis
T3069 17272-17285 GO:0032774 denotes RNA synthesis
T3070 17354-17357 GO:0006289 denotes NER
T3071 17378-17384 SO:0001026 denotes genome
T3072 17385-17388 GO:0006289 denotes NER
T3073 17393-17418 GO:0006283 denotes transcription-coupled NER
T3074 17430-17433 GO:0006289 denotes NER
T3075 17644-17647 PR:000007164 denotes Xpd
T3076 17659-17662 PR:000007164 denotes Xpd
T3077 17669-17676 NCBITaxon:33208 denotes animals
T3078 17701-17704 PR:000007164 denotes Xpd
T3079 17824-17835 CL:0000057 denotes fibroblasts
T3080 17911-17919 NCBITaxon:1 denotes organism
T3081 17921-17924 PR:000007164 denotes Xpd
T3082 18056-18059 PR:000007164 denotes Xpd
T3083 18134-18137 PR:000007164 denotes Xpd
T3084 18143-18149 SO:0001023 denotes allele
T3085 18153-18156 PR:000007164 denotes Xpd
T3086 18224-18227 PR:000007164 denotes Xpd
T4198 24267-24274 SO:0001023 denotes allelic
T4199 24376-24383 SO:0001023 denotes allelic
T4200 24429-24436 SO:0001023 denotes alleles
T4201 24592-24599 SO:0000704 denotes genetic
T4202 24622-24633 SO:0000704 denotes genetically
T4203 24642-24651 NCBITaxon:40674 denotes mammalian
T4204 24804-24807 PR:000007164 denotes Xpd
T4205 24808-24815 SO:0001023 denotes alleles
T4206 24832-24839 SO:0001023 denotes allelic
T4207 24895-24901 SO:0001023 denotes allele
T4208 25040-25045 NCBITaxon:9606 denotes human
T4209 25079-25082 PR:000007164 denotes Xpd
T4210 25083-25090 SO:0001023 denotes alleles
T4211 25201-25208 SO:0001023 denotes alleles
T4212 25261-25268 SO:0001023 denotes alleles
T4213 25447-25456 NCBITaxon:1 denotes organisms
T4214 25467-25473 NCBITaxon:9606 denotes humans
T4215 25528-25534 NCBITaxon:33208 denotes animal
T4216 25540-25543 PR:000007164 denotes Xpd
T4217 25544-25551 SO:0001023 denotes allelic
T4218 25694-25700 UBERON:0000479 denotes tissue
T4219 25765-25772 SO:0001023 denotes allelic
T4220 25795-25802 SO:0001023 denotes allelic
T4221 25831-25838 SO:0001023 denotes alleles
T4222 25982-25989 SO:0001023 denotes allelic
T4223 26028-26031 PR:000007164 denotes Xpd
T4224 26076-26080 UBERON:0001037 denotes hair
T4616 26105-26110 GO:0005675 denotes TFIIH
T4617 26132-26138 GO:0006281 denotes Repair
T4618 26154-26157 PR:000007164 denotes XPD
T4619 26219-26222 PR:000007164 denotes Xpd
T4620 26251-26254 PR:000007164 denotes Xpd
T4621 26264-26267 PR:000007164 denotes Xpd
T4622 26271-26278 SO:0001023 denotes alleles
T4623 26348-26356 NCBITaxon:1 denotes organism
T4624 26381-26390 UBERON:0000922 denotes embryonic
T4625 26414-26432 _FRAGMENT denotes differentiation of
T4626 26460-26465 GO:0030154 denotes cells
T4627 26433-26444 GO:0090601 denotes enucleating
T4628 26433-26444 _FRAGMENT denotes enucleating
T4629 26460-26465 CL:0000225 denotes cells
T4630 26454-26459 UBERON:0000178 denotes blood
T4631 26454-26465 CL:0000081 denotes blood cells
T4632 26474-26484 UBERON:0000358 denotes blastocyst
T4633 26526-26529 PR:000007164 denotes Xpd
T4634 26533-26536 PR:000007164 denotes Xpd
T4635 26547-26550 PR:000007164 denotes Xpd
T4636 26554-26561 SO:0001023 denotes alleles
T4637 26641-26645 UBERON:0000104 denotes life
T4638 26650-26653 PR:000007164 denotes Xpd
T4639 26668-26671 PR:000007164 denotes Xpd
T4640 26702-26706 NCBITaxon:10088 denotes mice
T4641 26708-26717 UBERON:0000922 denotes embryonic
T4642 26753-26756 PR:000007164 denotes Xpd
T4643 26760-26766 SO:0001023 denotes allele
T4644 26776-26785 UBERON:0000922 denotes embryonic
T4645 26822-26825 PR:000007164 denotes Xpd
T4646 26843-26847 NCBITaxon:10088 denotes mice
T4647 26853-26856 PR:000007164 denotes Xpd
T4648 26860-26866 SO:0001023 denotes allele
T4649 26942-26949 SO:0001023 denotes alleles
T4650 26951-26954 PR:000007164 denotes Xpd
T4651 26958-26961 PR:000007164 denotes Xpd
T4652 26972-26975 PR:000007164 denotes Xpd
T4653 27205-27210 GO:0005675 denotes TFIIH
T4654 27231-27249 _FRAGMENT denotes differentiation of
T4655 27278-27283 GO:0030154 denotes cells
T4656 27256-27266 UBERON:0002074 denotes hair-shaft
T4657 27256-27266 _FRAGMENT denotes hair-shaft
T4658 27278-27283 CL:0002559 denotes cells
T4659 27272-27277 UBERON:0000178 denotes blood
T4660 27272-27283 CL:0000081 denotes blood cells
T4661 27318-27322 NCBITaxon:10088 denotes mice
T4662 27347-27350 PR:000007164 denotes Xpd
T4663 27360-27363 PR:000007164 denotes Xpd
T4664 27367-27374 SO:0001023 denotes alleles
T4665 27398-27401 PR:000007164 denotes Xpd
T4666 27490-27493 PR:000007164 denotes Xpd
T4667 27497-27503 SO:0001023 denotes allele
T4668 27578-27587 UBERON:0000922 denotes embryonic
T4669 27649-27653 UBERON:0001037 denotes hair
T4670 27659-27664 UBERON:0000178 denotes blood
T4671 27762-27777 UBERON:0019248 denotes early embryonic
T4672 27768-27789 GO:0009790 denotes embryonic development
T4673 27791-27794 PR:000007164 denotes Xpd
T4674 27819-27822 PR:000007164 denotes Xpd
T4675 27832-27835 PR:000007164 denotes Xpd
T4676 27839-27846 SO:0001023 denotes alleles
T4677 27869-27888 GO:0043588 denotes ontogenesis of skin
T4678 27869-27883 _FRAGMENT denotes ontogenesis of
T4679 27912-27917 GO:0048468 denotes cells
T4680 27890-27900 UBERON:0002074 denotes hair-shaft
T4681 27890-27900 _FRAGMENT denotes hair-shaft
T4682 27912-27917 CL:0002559 denotes cells
T4683 27906-27911 UBERON:0000178 denotes blood
T4684 27906-27917 CL:0000081 denotes blood cells
T4685 27965-27971 GO:0006281 denotes repair
T4686 27996-27999 PR:000007164 denotes Xpd
T4687 28005-28011 SO:0001023 denotes allele
T4688 28063-28066 PR:000007164 denotes Xpd
T4689 28070-28076 SO:0001023 denotes allele
T4690 28084-28087 PR:000007164 denotes Xpd
T4691 28092-28099 SO:0001023 denotes alleles
T4692 28115-28125 GO:0010467 denotes expression
T4693 28164-28171 SO:0001023 denotes allelic
T4694 28291-28294 PR:000007164 denotes Xpd
T4695 28344-28350 GO:0006281 denotes repair
T5230 28415-28422 SO:0001023 denotes allelic
T5231 28443-28446 PR:000007164 denotes XPD
T5232 28471-28478 SO:0001023 denotes allelic
T5233 28526-28529 PR:000007164 denotes XPD
T5234 28545-28552 SO:0001023 denotes allelic
T5235 28595-28605 GO:0032991 denotes multimeric
T5236 28640-28647 SO:0000417 denotes domains
T5237 28738-28741 PR:000007164 denotes XPD
T5238 28753-28760 SO:0000417 denotes domains
T5239 28807-28810 PR:000007164 denotes XPD
T5240 28844-28849 GO:0005675 denotes TFIIH
T5241 28951-28956 GO:0005675 denotes TFIIH
T5242 28969-28972 PR:000007164 denotes XPD
T5243 28977-28980 PR:000007165 denotes XPB
T5244 28996-28999 GO:0006289 denotes NER
T5245 29042-29047 GO:0005675 denotes TFIIH
T5246 29123-29126 GO:0006289 denotes NER
T5247 29150-29153 PR:000007164 denotes XPD
T5248 29198-29203 GO:0005675 denotes TFIIH
T5249 29259-29266 SO:0001023 denotes allelic
T5250 29310-29313 PR:000007164 denotes XPD
T5251 29314-29323 CHEBI:36357 denotes molecules
T5252 29335-29348 GO:0005675 denotes TFIIH complex
T5253 29364-29379 GO:0005675 denotes TFIIH complexes
T5254 29401-29404 PR:000007164 denotes XPD
T5255 29405-29414 CHEBI:36357 denotes molecules
T5256 29473-29479 SO:0001026 denotes genome
T5257 29491-29522 _FRAGMENT denotes transcription-coupled repair of
T5258 29555-29565 GO:0006283 denotes DNA damage
T5515 29572-29579 SO:0001023 denotes allelic
T5516 29593-29596 PR:000007164 denotes XPD
T5517 29657-29664 SO:0001023 denotes alleles
T5518 29780-29787 SO:0001023 denotes alleles
T5519 29826-29834 NCBITaxon:4896 denotes S. pombe
T5520 29863-29866 PR:000007164 denotes XPD
T5521 29867-29876 SO:0000853 denotes homologue
T5522 29877-29882 PR:P26659 denotes rad15
T5523 29933-29940 SO:0001023 denotes alleles
T5524 30085-30091 NCBITaxon:9606 denotes humans
T5525 30107-30112 NCBITaxon:10088 denotes mouse
T5526 30284-30291 SO:0001023 denotes allelic
T5527 30304-30307 PR:000007164 denotes XPD
T5528 30360-30363 PR:000007164 denotes XPD
T5529 30390-30393 PR:000007164 denotes XPD
T5530 30402-30405 PR:000007164 denotes XPD
T5531 30420-30427 SO:0001023 denotes alleles
T5532 30432-30436 GO:0016265 denotes died
T5533 30497-30500 PR:000007164 denotes XPD
T5534 30532-30535 PR:000007164 denotes XPD
T5535 30544-30547 PR:000007164 denotes XPD
T5536 30562-30569 SO:0001023 denotes alleles
T5537 30603-30606 PR:000007164 denotes XPD
T5538 30888-30891 PR:000007164 denotes Xpd
T5539 30905-30908 PR:000007164 denotes Xpd
T5540 30916-30920 NCBITaxon:10088 denotes mice
T5541 30996-31000 UBERON:0001037 denotes hair
T5542 31094-31100 SO:0001023 denotes allele
T5543 31137-31140 PR:000007164 denotes XPD
T5544 31173-31176 PR:000007164 denotes XPD
T5545 31191-31197 SO:0001023 denotes allele
T5546 31243-31251 NCBITaxon:4896 denotes S. pombe
T5547 31252-31257 PR:P26659 denotes rad15
T5548 31310-31316 SO:0001023 denotes allele
T5549 31439-31446 SO:0001023 denotes alleles
T5550 31498-31505 SO:0001023 denotes allelic
T5983 32389-32396 SO:0001023 denotes Alleles
T5984 32431-32438 NCBITaxon:40674 denotes Mammals
T5985 32442-32448 NCBITaxon:9606 denotes humans
T5986 32478-32485 SO:0001023 denotes allelic
T5987 32507-32514 SO:0001023 denotes allelic
T5988 32562-32569 SO:0001023 denotes allelic
T5989 32616-32623 SO:0001023 denotes alleles
T5990 32694-32707 CHEBI:30860 denotes methylmalonic
T5991 32941-32948 NCBITaxon:33208 denotes animals
T5992 32957-32964 SO:0001023 denotes allelic
T5993 32995-33000 NCBITaxon:9606 denotes human
T5994 33042-33049 SO:0001023 denotes alleles
T5995 33073-33077 PR:000001044 denotes CTRF
T5996 33078-33082 SO:0000704 denotes gene
T5997 33108-33117 GO:0030849 denotes autosomal
T5998 33211-33218 SO:0001023 denotes allelic
T5999 33257-33264 SO:0001023 denotes allelic
T6000 33315-33346 SO:0000694 denotes single nucleotide polymorphisms
T6001 33347-33353 SO:0001026 denotes genome
T6002 33399-33406 SO:0001023 denotes allelic
T6003 33522-33531 GO:0030849 denotes autosomal
T6004 33584-33591 NCBITaxon:40674 denotes mammals
T6005 33721-33727 SO:0001023 denotes allele
T6006 33835-33842 SO:0001023 denotes alleles
T6007 33903-33913 GO:0010467 denotes expression
T6321 34328-34333 NCBITaxon:10088 denotes mouse
T6322 34334-34343 UBERON:0000922 denotes embryonic
T6323 34344-34355 CL:0000057 denotes fibroblasts
T6324 34405-34417 CHEBI:51686 denotes Haematoxylin
T6325 34541-34546 UBERON:0000178 denotes Blood
T6326 34574-34580 NCBITaxon:33208 denotes Animal
T6327 34581-34586 UBERON:0000178 denotes Blood
T6328 34680-34687 CHEBI:46662 denotes mineral
T6329 34733-34737 NCBITaxon:10088 denotes Mice
T6330 34850-34854 NCBITaxon:10088 denotes mice
T6331 34910-34917 SO:0000704 denotes genetic
T6332 34936-34945 NCBITaxon:1 denotes organisms
T6333 34954-34960 NCBITaxon:33208 denotes animal
T6945 8655-8662 SO:0001026 denotes genomic
T6903 7563-7568 NCBITaxon:10088 denotes Mouse
T6904 7569-7572 PR:000007164 denotes Xpd
T6905 7573-7577 SO:0000704 denotes Gene
T6906 7614-7621 SO:0001026 denotes genomic
T6907 7644-7659 SO:0001250 denotes restriction map
T6908 7683-7688 NCBITaxon:10088 denotes mouse
T6909 7689-7692 PR:000007164 denotes Xpd
T6910 7710-7713 PR:000007164 denotes Xpd
T6911 7714-7720 SO:0001023 denotes allele
T6912 7745-7768 SO:0001215 denotes coding regions of exons
T6913 7787-7792 SO:0000205 denotes 3′UTR
T6914 7842-7860 GO:0006415 denotes translational stop
T6915 7842-7866 SO:0000319 denotes translational stop codon
T6916 7868-7873 SO:0000551 denotes PolyA
T6917 7888-7903 GO:0043631 denotes polyadenylation
T6918 7888-7910 SO:0000551 denotes polyadenylation signal
T6919 7920-7923 PR:000007164 denotes Xpd
T6920 7936-7942 SO:0001023 denotes allele
T6921 7952-7961 SO:0000028 denotes base pair
T6922 7963-7965 SO:0000028 denotes bp
T6923 7967-7972 NCBITaxon:9606 denotes human
T6924 7973-7976 PR:000007164 denotes XPD
T6925 8000-8004 SO:0000147 denotes exon
T6926 8104-8111 NCBITaxon:9031 denotes Chicken
T6927 8112-8120 PR:000008457 denotes β-globin
T6928 8114-8120 CHEBI:5386 denotes globin
T6929 8121-8126 SO:0000147 denotes exons
T6930 8149-8154 SO:0000205 denotes 3′UTR
T6931 8234-8242 PR:000008457 denotes β-globin
T6932 8236-8242 CHEBI:5386 denotes globin
T6933 8243-8258 GO:0043631 denotes polyadenylation
T6934 8243-8265 SO:0000551 denotes polyadenylation signal
T6935 8267-8273 SO:0000551 denotes PolyA*
T6936 8284-8287 PR:000007164 denotes Xpd
T6937 8295-8298 PR:000007164 denotes Xpd
T6938 8313-8320 SO:0001023 denotes alleles
T6939 8406-8411 SO:0000147 denotes exons
T6940 8530-8547 SO:0000061 denotes Restriction sites
T6941 8549-8550 PR:P23940 denotes B
T6942 8552-8557 PR:P23940 denotes BamHI
T6943 8578-8579 PR:P43870 denotes H
T6944 8581-8588 PR:P43870 denotes HindIII
T6946 8676-8679 PR:000007164 denotes Xpd
T6947 8693-8696 PR:000007164 denotes Xpd
T6948 8715-8724 UBERON:0000922 denotes embryonic
T6949 8715-8734 CL:0002322 denotes embryonic stem cell
T6950 8742-8752 GO:0097617 denotes hybridised
T6951 8795-8801 SO:0001023 denotes allele
T6952 8861-8864 PR:000007164 denotes Xpd
T6953 8872-8875 PR:000007164 denotes Xpd
T6954 8881-8888 SO:0001023 denotes alleles
T6955 8948-8955 SO:0001023 denotes alleles
T6956 8969-8976 SO:0000112 denotes primers
T6957 9036-9038 SO:0000028 denotes bp
T6958 9047-9049 SO:0000028 denotes bp
T6959 9094-9104 GO:0010467 denotes expression
T6960 9149-9156 SO:0001023 denotes alleles
T6961 9160-9169 UBERON:0000922 denotes embryonic
T6962 9160-9179 CL:0002322 denotes embryonic stem cell
T6963 9193-9200 SO:0000112 denotes primers
T6964 9205-9216 GO:0097617 denotes hybridising
T6965 9296-9298 SO:0000028 denotes bp
T6966 9363-9369 UBERON:0000473 denotes testis
T6967 9391-9394 PR:000007164 denotes Xpd
T6968 9416-9419 PR:000007164 denotes Xpd
T6969 9469-9472 PR:000007164 denotes Xpd
T6970 9482-9486 NCBITaxon:10088 denotes mice
T6971 9501-9514 GO:0097617 denotes Hybridisation
T6972 9529-9534 NCBITaxon:10088 denotes mouse
T6973 9535-9538 PR:000007164 denotes Xpd
T6974 9595-9598 PR:000007164 denotes Xpd
T6975 9609-9612 PR:000007164 denotes Xpd
T6976 9616-9623 SO:0001023 denotes alleles
T6977 9642-9658 CHEBI:4883 denotes ethidium bromide
T6978 9660-9664 CHEBI:4883 denotes EtBr
T7587 11970-11975 UBERON:0000178 denotes Blood
T7588 12031-12034 PR:000007164 denotes Xpd
T7589 12044-12048 NCBITaxon:10088 denotes Mice
T7590 12088-12091 PR:000007164 denotes Xpd
T7591 12122-12125 PR:000007164 denotes Xpd
T7592 12143-12147 NCBITaxon:10088 denotes mice
T7593 12179-12183 UBERON:0001037 denotes hair
T7594 12231-12234 PR:000007164 denotes Xpd
T7595 12243-12246 PR:000007164 denotes Xpd
T7596 12264-12268 NCBITaxon:10088 denotes mice
T7597 12305-12314 UBERON:0007376 denotes epidermis
T7598 12404-12419 UBERON:0001821 denotes sebacious gland
T7599 12487-12496 UBERON:0007376 denotes epidermis
T7600 12500-12503 PR:000007164 denotes Xpd
T7601 12520-12524 NCBITaxon:10088 denotes mice
T7602 12570-12574 UBERON:0001037 denotes hair
T7603 12584-12587 PR:000007164 denotes Xpd
T7604 12600-12603 PR:000007164 denotes Xpd
T7605 12613-12617 NCBITaxon:10088 denotes mice
T7606 12708-12711 PR:000007164 denotes Xpd
T7607 12723-12726 PR:000007164 denotes Xpd
T7608 12736-12740 NCBITaxon:10088 denotes mice
T7609 12823-12828 UBERON:0000178 denotes blood
T7610 12832-12835 PR:000007164 denotes Xpd
T7611 12847-12850 PR:000007164 denotes Xpd
T7612 12860-12864 NCBITaxon:10088 denotes mice
T7613 12995-12998 PR:000007164 denotes Xpd
T7614 13010-13013 PR:000007164 denotes Xpd
T7615 13023-13027 NCBITaxon:10088 denotes mice
T7952 14931-14934 PR:000007164 denotes Xpd
T7953 14945-14949 NCBITaxon:10088 denotes Mice
T7954 15005-15008 PR:000007164 denotes Xpd
T7955 15034-15037 PR:000007164 denotes Xpd
T7956 15045-15049 NCBITaxon:10088 denotes mice
T7957 15086-15102 UBERON:0002190 denotes subcutaneous fat
T7958 15111-15114 PR:000007164 denotes Xpd
T7959 15122-15127 NCBITaxon:10088 denotes mouse
T7960 15172-15175 PR:000007164 denotes Xpd
T7961 15185-15189 NCBITaxon:10088 denotes mice
T7962 15229-15232 PR:000007164 denotes Xpd
T7963 15247-15250 PR:000007164 denotes Xpd
T7964 15258-15262 NCBITaxon:10088 denotes mice
T7965 15264-15270 GO:0007568 denotes Ageing
T7966 15271-15274 PR:000007164 denotes Xpd
T7967 15282-15286 NCBITaxon:10088 denotes mice
T7968 15322-15335 UBERON:0001130 denotes spinal column
T7969 15359-15366 CHEBI:46662 denotes mineral
T7970 15410-15414 UBERON:0002415 denotes tail
T7971 15415-15424 UBERON:0002412 denotes vertebrae
T7972 15442-15448 UBERON:0002355 denotes pelvis
T7973 15516-15519 PR:000007164 denotes Xpd
T7974 15532-15537 NCBITaxon:10088 denotes mouse
T7975 15575-15582 CHEBI:46662 denotes mineral
T7976 15594-15598 UBERON:0002415 denotes tail
T7977 15599-15608 UBERON:0002412 denotes vertebrae
T7978 15641-15644 PR:000007164 denotes Xpd
T7979 15667-15670 PR:000007164 denotes Xpd
T7980 15686-15690 NCBITaxon:10088 denotes mice
T7981 15761-15764 PR:000007164 denotes Xpd
T7982 15893-15896 PR:000007164 denotes Xpd
T7983 15904-15908 NCBITaxon:10088 denotes mice
T7984 15945-15948 PR:000007164 denotes Xpd
T7985 15960-15964 NCBITaxon:10088 denotes mice
T7986 16005-16008 PR:000007164 denotes Xpd
T7987 16039-16042 PR:000007164 denotes Xpd
T7988 16052-16056 NCBITaxon:10088 denotes mice
T8414 19783-19786 PR:000007164 denotes Xpd
T8415 20031-20037 SO:0001026 denotes genome
T8416 20038-20044 GO:0006281 denotes repair
T8417 20077-20080 PR:000007164 denotes Xpd
T8418 20097-20100 PR:000007164 denotes Xpd
T8419 20116-20119 PR:000007164 denotes Xpd
T8420 20139-20142 PR:000007164 denotes Xpd
T8421 20266-20269 PR:000007164 denotes Xpd
T8422 20324-20327 PR:000007164 denotes Xpd
T8423 20360-20388 GO:0006283 denotes transcription-coupled repair
T8424 20442-20445 PR:000007164 denotes Xpd
T8425 20462-20465 PR:000007164 denotes Xpd
T8426 20481-20484 PR:000007164 denotes Xpd
T8427 20504-20507 PR:000007164 denotes Xpd
T8428 20584-20592 MOP:0000780 denotes Incision
T8429 20638-20653 GO:0005675 denotes TFIIH complexes
T8430 20673-20676 GO:0006289 denotes NER
T8431 20747-20753 GO:0005675 denotes TFIIHs
T8432 20766-20769 PR:000007164 denotes XPD
T8433 20771-20774 PR:000007165 denotes XPB
T8434 20776-20779 PR:000008317 denotes p62
T8435 20781-20784 PR:000008320 denotes p52
T8436 20790-20793 PR:000008318 denotes p44
T8437 20800-20803 PR:000008319 denotes p34
T8438 20805-20809 PR:000005265 denotes cdk7
T8439 20811-20819 PR:000005130 denotes cyclin H
T8440 20821-20825 PR:000010496 denotes Mat1
T8441 20831-20833 PR:000008321 denotes p8
T8442 20863-20866 PR:000007167 denotes XPG
T8443 20868-20871 PR:000007166 denotes XPF
T8444 20872-20877 PR:000007163 denotes ERCC1
T8445 20879-20882 PR:000017494 denotes XPC
T8446 20883-20889 PR:000013670 denotes hHR23B
T8447 20891-20894 GO:0005662 denotes RPA
T8448 20926-20929 GO:0006289 denotes NER
T8449 21149-21162 GO:0005675 denotes TFIIH complex
T8450 21239-21242 PR:000007164 denotes Xpd
T8451 21271-21276 GO:0005675 denotes TFIIH
T8452 21291-21294 PR:000007164 denotes Xpd
T8453 21314-21317 PR:000007164 denotes Xpd
T8454 21351-21354 PR:000007164 denotes Xpd
T8455 21368-21371 PR:000007164 denotes Xpd
T8456 21426-21446 PR:000008317 denotes p62 subunit of TFIIH
T8457 21441-21446 GO:0005675 denotes TFIIH
T8458 21607-21610 PR:000007164 denotes Xpd
T8459 21652-21655 PR:000007164 denotes Xpd
T8460 21737-21740 PR:000007164 denotes Xpd
T8461 21830-21833 PR:000007164 denotes Xpd
T8462 21930-21936 GO:0005634 denotes nuclei
T6312 34025-34029 NCBITaxon:10088 denotes mice
T6313 34045-34048 PR:000007164 denotes Xpd
T6314 34053-34056 PR:000007164 denotes XPD
T6315 34067-34070 PR:000007164 denotes Xpd
T6316 34077-34081 NCBITaxon:10088 denotes mice
T6317 34190-34193 PR:000007164 denotes Xpd
T6318 34203-34206 PR:000007164 denotes Xpd
T6319 34211-34218 SO:0001023 denotes alleles
T6320 34319-34323 NCBITaxon:10088 denotes mice
T6564 35088-35093 GO:0005675 denotes TFIIH
T6565 35094-35102 MOP:0000780 denotes incision
T6566 35296-35299 PR:000007164 denotes Xpd
T6567 35312-35315 PR:000007164 denotes Xpd
T6568 35333-35336 PR:000007164 denotes Xpd
T6569 35418-35421 PR:000007164 denotes Xpd
T6570 35624-35632 MOP:0000780 denotes incision
T6571 35670-35675 GO:0005675 denotes TFIIH
T6750 35836-35850 _FRAGMENT denotes p62 subunit of
T6751 35855-35860 PR:000008317 denotes TFIIH
T6752 35855-35860 GO:0005675 denotes TFIIH
T6753 35921-35926 NCBITaxon:10088 denotes mouse
T6754 35927-35936 UBERON:0000922 denotes embryonic
T6755 35937-35948 CL:0000057 denotes fibroblasts
T6756 36018-36021 PR:000007164 denotes Xpd
T9203 9755-9758 PR:000007164 denotes Xpd
T9204 9767-9770 PR:000007164 denotes Xpd
T9205 9809-9812 PR:000007164 denotes Xpd
T9206 9822-9829 UBERON:0000922 denotes Embryos
T9234 16166-16169 PR:000007164 denotes Xpd
T9235 16172-16179 SO:0001023 denotes allelic
T9236 16191-16195 NCBITaxon:10088 denotes Mice
T9254 31627-31630 PR:000007164 denotes XPD
T9255 31670-31677 SO:0001023 denotes allelic
T9256 31738-31744 SO:0001023 denotes allele
T9257 31777-31783 SO:0001023 denotes allele
T9258 31891-31894 PR:000007164 denotes XPD
T9259 31947-31954 SO:0001023 denotes allelic
T9260 32007-32014 SO:0001023 denotes alleles
T9261 32124-32130 SO:0001023 denotes allele
T9262 32277-32283 SO:0001023 denotes allele
T9263 32347-32354 SO:0000417 denotes domains
T1842 13216-13225 UBERON:0007376 denotes epidermis
T1843 13267-13275 _FRAGMENT denotes layer of
T1844 13290-13295 UBERON:0000119 denotes cells
T1845 13280-13289 GO:0005634 denotes nucleated
T1327 7010-7023 GO:0009790 denotes embryogenesis
T1328 7088-7091 PR:000007164 denotes Xpd
T1329 7110-7113 PR:000007164 denotes XPD
T1330 7175-7181 NCBITaxon:9606 denotes humans
T1331 7202-7211 GO:0010467 denotes expressed
T1332 7266-7272 SO:0001023 denotes allele
T1333 7387-7392 SO:0000205 denotes 3′UTR
T1334 7416-7420 SO:0000704 denotes gene
T1335 7450-7453 PR:000007164 denotes Xpd
T1336 7492-7495 PR:000007164 denotes Xpd
T1337 7506-7509 PR:000007164 denotes XPD
T1338 7522-7529 NCBITaxon:33208 denotes animals
T2478 13822-13826 NCBITaxon:10088 denotes Mice
T2479 13848-13851 PR:000007164 denotes Xpd
T2480 13852-13859 SO:0001023 denotes Alleles
T2481 13935-13940 NCBITaxon:10088 denotes mouse
T2482 14026-14032 GO:0007568 denotes ageing
T2483 14077-14081 NCBITaxon:10088 denotes mice
T2484 14102-14105 PR:000007164 denotes Xpd
T2485 14113-14120 NCBITaxon:33208 denotes animals
T2486 14139-14146 CHEBI:46662 denotes mineral
T2487 14234-14238 UBERON:0002415 denotes tail
T2488 14239-14248 UBERON:0002412 denotes vertebrae
T2489 14276-14279 PR:000007164 denotes Xpd
T2490 14289-14293 NCBITaxon:10088 denotes mice
T2491 14378-14381 PR:000007164 denotes Xpd
T2492 14389-14393 NCBITaxon:10088 denotes mice
T2501 16249-16252 PR:000007164 denotes Xpd
T2502 16258-16264 SO:0001023 denotes allele
T2503 16334-16337 PR:000007164 denotes Xpd
T2504 16341-16347 SO:0001023 denotes allele
T2505 16384-16387 PR:000007164 denotes Xpd
T2506 16395-16399 NCBITaxon:10088 denotes mice
T2507 16443-16450 NCBITaxon:33208 denotes animals
T2508 16467-16470 PR:000007164 denotes Xpd
T2509 16477-16483 SO:0001023 denotes allele
T2510 16507-16510 PR:000007164 denotes Xpd
T1846 13280-13295 CL:0002242 denotes nucleated cells
T1838 11725-11732 NCBITaxon:33208 denotes animals
T1839 11796-11799 PR:000007164 denotes Xpd
T1840 11905-11908 PR:000007164 denotes Xpd
T1841 11916-11920 NCBITaxon:10088 denotes mice
T1847 13342-13351 GO:0070268 denotes cornified
T1848 13342-13357 UBERON:0002027 denotes cornified layer
T1849 13394-13409 UBERON:0001821 denotes sebacious gland
T1850 13456-13460 UBERON:0001037 denotes hair
T1851 13490-13493 PR:000007164 denotes Xpd
T1852 13503-13507 NCBITaxon:10088 denotes mice
T1853 13673-13676 PR:000007164 denotes Xpd
T1854 13684-13688 NCBITaxon:10088 denotes mice
T1855 13747-13750 PR:000007164 denotes Xpd
T1856 13760-13764 NCBITaxon:10088 denotes mice
T8405 19446-19451 GO:0005675 denotes TFIIH
T8406 19480-19483 PR:000007164 denotes XPD
T8407 19579-19582 PR:000007164 denotes Xpd
T8408 19601-19604 PR:000007164 denotes Xpd
T8409 19614-19617 PR:000007164 denotes Xpd
T8410 19621-19628 SO:0001023 denotes alleles
T8411 19710-19713 PR:000007164 denotes Xpd
T8412 19758-19767 GO:0010467 denotes expressed
T8413 19775-19781 SO:0001023 denotes allele
T3087 18231-18237 SO:0001023 denotes allele
T3088 18262-18271 UBERON:0000922 denotes embryonic
T3089 18363-18366 PR:000007164 denotes Xpd
T3090 18375-18378 PR:000007164 denotes Xpd
T3091 18382-18389 SO:0001023 denotes alleles
T3092 18411-18414 PR:000007164 denotes XPD
T3093 18418-18421 PR:000007164 denotes XPD
T3094 18443-18446 PR:000007164 denotes XPD
T3095 18452-18455 PR:000007164 denotes XPD
T3096 18462-18467 NCBITaxon:9606 denotes human
T3097 18560-18563 PR:000007164 denotes Xpd
T3098 18574-18577 PR:000007164 denotes XPD
T3099 18590-18595 NCBITaxon:10088 denotes mouse
T3100 18655-18658 PR:000007164 denotes Xpd
T3101 18673-18676 PR:000007164 denotes Xpd
T3102 18754-18760 SO:0001023 denotes allele
T3103 18844-18847 GO:0006289 denotes NER
T3104 18872-18875 PR:000007164 denotes Xpd
T3105 18905-18908 PR:000007164 denotes Xpd
T3106 18980-18985 GO:0005675 denotes TFIIH
T3107 19042-19045 PR:000007164 denotes XPD
T3108 19059-19062 PR:000007164 denotes XPD
T3109 19077-19080 PR:000007164 denotes XPD
T3110 19123-19126 GO:0006289 denotes NER
T3111 19172-19187 GO:0005675 denotes TFIIH complexes
T3112 19253-19260 SO:0001023 denotes allelic
T3113 19366-19372 GO:0006281 denotes repair
T3114 19421-19427 NCBITaxon:33208 denotes animal
T3115 22273-22274 GO:0006283 denotes t
T3116 22277-22278 PR:000007164 denotes X
T3117 22278-22279 PR:000008317 denotes p
T3118 22279-22280 PR:000005265 denotes d
T3119 22290-22293 PR:000007164 denotes Xpd
T3120 22306-22307 PR:000007164 denotes d
T3121 22309-22310 PR:000007164 denotes p
T3122 22321-22322 GO:0005634 denotes e
T3123 22384-22389 GO:0005675 denotes TFIIH
T3124 22422-22425 PR:000007164 denotes Xpd
T3125 22440-22443 PR:000007164 denotes Xpd
T3126 22562-22567 GO:0005675 denotes TFIIH
T3127 22586-22597 CL:0000057 denotes fibroblasts
T3128 22693-22703 GO:0010467 denotes expression
T3129 22721-22724 PR:000007164 denotes Xpd
T3130 22728-22734 SO:0001023 denotes allele
T3131 22754-22760 SO:0001023 denotes allele
T3132 22774-22779 GO:0005675 denotes TFIIH
T3133 22826-22831 NCBITaxon:10088 denotes mouse
T3134 22832-22835 PR:000007164 denotes Xpd
T3135 22843-22854 CL:0000057 denotes fibroblasts
T3136 22910-22915 NCBITaxon:9606 denotes human
T3137 22958-22962 SO:0000704 denotes gene
T3138 23047-23050 PR:000007164 denotes Xpd
T3139 23089-23099 GO:0010467 denotes expression
T3140 23120-23123 PR:000007164 denotes Xpd
T3141 23137-23140 PR:000007164 denotes Xpd
T3142 23144-23150 SO:0001023 denotes allele
T3143 23171-23176 GO:0005675 denotes TFIIH
T3144 23203-23206 PR:000007164 denotes Xpd
T3145 23433-23438 GO:0005675 denotes TFIIH
T3146 23571-23581 GO:0010467 denotes expression
T3147 23629-23632 PR:000007164 denotes XPD
T3148 23658-23662 UBERON:0001037 denotes hair
T3149 23693-23696 PR:000007164 denotes Xpd
T3150 23707-23714 NCBITaxon:33208 denotes animals
T3151 23733-23737 UBERON:0001037 denotes hair
T3152 23780-23783 PR:000007164 denotes Xpd
T3153 23789-23799 GO:0010467 denotes expression
T3154 23809-23812 PR:000007164 denotes Xpd
T3155 23821-23828 NCBITaxon:33208 denotes animals
T3156 23836-23840 UBERON:0001037 denotes hair
T3157 23866-23876 GO:0010467 denotes expression
T3158 23900-23903 PR:000007164 denotes Xpd
T3159 23908-23914 SO:0001023 denotes allele
T3160 23966-23976 GO:0010467 denotes expression
T3161 24006-24013 SO:0001023 denotes alleles
T3162 24068-24072 UBERON:0001037 denotes hair
T3163 24127-24130 PR:000007164 denotes Xpd
T3164 24131-24138 SO:0001023 denotes alleles
T3165 24180-24185 GO:0005675 denotes TFIIH
T3166 24198-24202 NCBITaxon:10088 denotes mice
R1224 T1844 T1843 _lexicallyChainedTo cells,layer of
R3168 T4626 T4625 _lexicallyChainedTo cells,differentiation of
R3169 T4629 T4628 _lexicallyChainedTo cells,enucleating
R3170 T4655 T4654 _lexicallyChainedTo cells,differentiation of
R3171 T4658 T4657 _lexicallyChainedTo cells,hair-shaft
R3172 T4679 T4678 _lexicallyChainedTo cells,ontogenesis of
R3173 T4682 T4681 _lexicallyChainedTo cells,hair-shaft
R3563 T5258 T5257 _lexicallyChainedTo DNA damage,transcription-coupled repair of
R4647 T6751 T6750 _lexicallyChainedTo TFIIH,p62 subunit of

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T47 0-6 SO_EXT:sequence_rescue_process denotes Rescue
T48 56-62 GO_EXT:fatality_or_lethality denotes Lethal
T49 63-66 PR_EXT:000007164 denotes Xpd
T50 67-74 SO_EXT:0001023 denotes Alleles
T51 192-198 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T52 199-206 SO_EXT:0001023 denotes alleles
T53 219-223 SO_EXT:0000704 denotes gene
T54 238-243 NCBITaxon:9606 denotes human
T55 417-424 SO_EXT:0001023 denotes allelic
T56 468-475 SO_EXT:0000704 denotes genetic
T57 538-545 SO_EXT:0001023 denotes alleles
T58 604-607 PR_EXT:000007164 denotes XPD
T59 653-658 NCBITaxon:10088 denotes mouse
T60 667-678 SO_EXT:sequence_alteration_entity_or_process denotes Alterations
T61 697-705 GO_EXT:0004386 denotes helicase
T62 730-733 CHEBI_SO_EXT:DNA denotes DNA
T63 730-740 GO:0006281 denotes DNA repair
T64 751-764 GO_EXT:transcription denotes transcription
T65 919-926 SO_EXT:0001023 denotes allelic
T66 938-948 NCBITaxon:1 denotes organismal
T67 1001-1004 PR_EXT:000007164 denotes Xpd
T68 1005-1012 SO_EXT:0001023 denotes alleles
T69 1069-1075 GO_EXT:fatality_or_lethality denotes lethal
T70 1076-1079 PR_EXT:000007164 denotes Xpd
T71 1080-1087 SO_EXT:0001023 denotes alleles
T72 1159-1172 GO_EXT:transcription denotes transcription
T73 1225-1231 SO_EXT:0001023 denotes allele
T74 1269-1275 UBERON:0000479 denotes tissue
T75 1307-1310 PR_EXT:000007164 denotes Xpd
T76 1311-1317 SO_EXT:0001023 denotes allele
T77 1343-1350 SO_EXT:0001023 denotes allelic
T78 1428-1435 NCBITaxon:40674 denotes mammals
T79 1494-1498 SO_EXT:sequence_nullness denotes null
T80 1500-1507 SO_EXT:0001023 denotes alleles
T81 1511-1514 PR_EXT:000007164 denotes XPD
T82 1582-1589 SO_EXT:0001023 denotes alleles
T83 1654-1661 NCBITaxon:40674 denotes mammals
T465 1905-1912 SO_EXT:0001023 denotes allelic
T466 1977-1984 SO_EXT:sequence_alteration_process denotes mutated
T467 1985-1992 SO_EXT:0001023 denotes alleles
T468 2088-2097 NCBITaxon:1 denotes organisms
T469 2160-2165 NCBITaxon:9606 denotes human
T470 2213-2220 SO_EXT:0001023 denotes allelic
T471 2279-2290 CHEBI_EXT:biochemical denotes biochemical
T472 2295-2299 CL_GO_EXT:cell denotes cell
T473 2330-2339 GO:0008152 denotes metabolic
T474 2366-2373 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T475 2384-2396 CHEBI:15539 denotes propinyl-CoA
T476 2384-2408 GO_EXT:0004658 denotes propinyl-CoA carboxylase
T477 2414-2431 CHEBI:57472 denotes argininosuccinate
T478 2414-2437 GO_PR_EXT:argininosuccinate_lyase denotes argininosuccinate lyase
T479 2443-2464 CHEBI:53025 denotes galactose-1-phosphate
T480 2443-2484 GO_PR_EXT:galactose_1_phosphate_uridylyltransferase denotes galactose-1-phosphate uridylyltransferase
T481 2494-2511 CHEBI:16625 denotes methylmalonyl CoA
T482 2494-2518 GO_PR_EXT:methylmalonyl_CoA_mutase denotes methylmalonyl CoA mutase
T483 2551-2562 NCBITaxon:1 denotes individuals
T484 2586-2592 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T485 2593-2600 SO_EXT:0001023 denotes alleles
T486 2613-2617 SO_EXT:0000704 denotes gene
T487 2649-2658 SO_EXT:wild_type_entity_or_quality denotes wild-type
T488 2660-2662 SO_EXT:wild_type_entity_or_quality denotes wt
T489 2665-2671 SO_EXT:0001023 denotes allele
T490 2673-2680 SO_EXT:0000704 denotes genetic
T491 2712-2719 SO_EXT:0001023 denotes alleles
T492 2744-2751 SO_EXT:0001023 denotes allelic
T493 2823-2830 SO_EXT:0001023 denotes allelic
T494 2898-2905 SO_EXT:0001023 denotes allelic
T495 3009-3016 SO_EXT:0001023 denotes allelic
T496 3044-3051 SO_EXT:0001023 denotes allelic
T497 3063-3068 NCBITaxon:9606 denotes human
T498 3164-3171 SO_EXT:0000704 denotes genetic
T499 3184-3187 PR_EXT:000007164 denotes XPD
T500 3188-3195 SO_EXT:sequence_coding_function denotes encodes
T501 3211-3219 GO_EXT:0004386 denotes helicase
T502 3234-3275 GO:0005675 denotes basal transcription/DNA repair factor IIH
T503 3240-3253 GO_EXT:transcription denotes transcription
T504 3240-3253 _FRAGMENT denotes transcription
T505 3265-3271 GO_EXT:transcription_factor denotes factor
T506 3254-3257 CHEBI_SO_EXT:DNA denotes DNA
T507 3254-3264 GO:0006281 denotes DNA repair
T508 3277-3282 GO:0005675 denotes TFIIH
T509 3316-3323 GO:0032991 denotes complex
T510 3382-3395 GO_EXT:transcription denotes transcription
T511 3411-3414 CHEBI_SO_EXT:DNA denotes DNA
T512 3411-3428 GO:0006281 denotes DNA damage repair
T513 3437-3447 CHEBI_SO_EXT:nucleotide denotes nucleotide
T514 3437-3463 GO:0006289 denotes nucleotide excision repair
T515 3448-3456 SO_EXT:sequence_deletion_process denotes excision
T516 3465-3468 GO:0006289 denotes NER
T517 3485-3496 SO_EXT:sequence_alteration_entity_or_process denotes Alterations
T518 3500-3503 PR_EXT:000007164 denotes XPD
T519 3527-3532 GO:0005675 denotes TFIIH
T520 3581-3587 UBERON:0000467 denotes system
T521 3743-3755 GO_PATO_EXT:biological_pigmentation_process_or_quality denotes pigmentation
T522 3809-3813 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T523 3862-3868 GO_EXT:biological_growth_entity_or_process denotes growth
T524 4016-4021 GO:0007567 denotes natal
T525 4022-4028 GO_EXT:biological_growth_entity_or_process denotes growth
T526 4051-4062 GO_EXT:myelin_assembly_or_myelination denotes myelination
T527 4200-4207 CHEBI_EXT:sulfur denotes sulphur
T528 4226-4230 UBERON:0001037 denotes hair
T529 4235-4240 UBERON:0001705 denotes nails
T530 4253-4257 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T531 4287-4300 GO_EXT:transcription denotes transcription
T532 4320-4324 CL_GO_EXT:cell denotes cell
T533 4414-4432 GO:0007399 denotes neurodevelopmental
T534 4511-4514 PR_EXT:000007164 denotes XPD
T535 4515-4524 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T536 4583-4586 PR_EXT:000007164 denotes XPD
T537 4605-4608 PR_EXT:000007164 denotes XPD
T538 4688-4695 SO_EXT:0001023 denotes Alleles
T539 4764-4768 SO_EXT:sequence_nullness denotes null
T540 4770-4777 SO_EXT:0001023 denotes alleles
T541 4801-4808 SO_EXT:0001023 denotes alleles
T542 4848-4879 NCBITaxon:4896 denotes Schizosaccharomyces pombe yeast
T543 4894-4898 SO_EXT:sequence_nullness denotes null
T544 4899-4907 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T545 4915-4918 PR_EXT:000007164 denotes XPD
T546 4919-4928 SO_EXT:0000853 denotes homologue
T547 4929-4934 PR_EXT:P26659 denotes rad15
T548 4981-4991 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biological
T549 5030-5037 SO_EXT:0001023 denotes alleles
T550 5061-5065 SO_EXT:sequence_nullness denotes null
T551 5111-5118 SO_EXT:0001023 denotes allelic
T552 5132-5135 PR_EXT:000007164 denotes XPD
T553 5348-5355 SO_EXT:0001023 denotes allelic
T554 5457-5462 NCBITaxon:10088 denotes mouse
T555 5470-5473 PR_EXT:000007164 denotes XPD
T556 5501-5506 NCBITaxon:9606 denotes human
T557 5569-5575 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T558 5576-5579 PR_EXT:000007164 denotes Xpd
T559 5580-5587 SO_EXT:0001023 denotes alleles
T560 5695-5701 GO:0007568 denotes ageing
T561 5703-5712 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T562 5723-5731 CL_GO_EXT:cell denotes cellular
T563 5732-5735 CHEBI_SO_EXT:DNA denotes DNA
T564 5732-5742 GO:0006281 denotes DNA repair
T1339 5840-5843 PR_EXT:000007164 denotes Xpd
T1340 5883-5886 PR_EXT:000007164 denotes Xpd
T1341 5896-5902 SO_EXT:0001023 denotes allele
T1342 5910-5924 SO_EXT:point_mutation_entity_or_process denotes point mutation
T1343 5925-5933 SO_EXT:sequence_coding_function denotes encoding
T1344 5943-5953 CHEBI_SO_EXT:amino_acid denotes amino acid
T1345 5954-5960 SO_EXT:sequence_alteration_entity_or_process denotes change
T1346 5962-5965 PR_EXT:000007164 denotes XPD
T1347 6020-6024 CHEBI_SO_EXT:mRNA denotes mRNA
T1348 6025-6035 GO:0010467 denotes expression
T1349 6054-6060 SO_EXT:0001023 denotes allele
T1350 6082-6091 UBERON:0000922 denotes embryonic
T1351 6082-6102 CL:0002322 denotes embryonic stem cells
T1352 6097-6102 CL_GO_EXT:cell denotes cells
T1353 6106-6108 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T1354 6135-6145 GO:0010467 denotes expression
T1355 6191-6193 SO_EXT:wild_type_entity_or_quality denotes wt
T1356 6194-6198 CHEBI_SO_EXT:mRNA denotes mRNA
T1357 6255-6258 CHEBI_SO_EXT:RNA denotes RNA
T1358 6268-6274 UBERON:0000473 denotes testis
T1359 6291-6298 NCBITaxon:33208 denotes animals
T1360 6356-6362 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1361 6363-6366 PR_EXT:000007164 denotes XPD
T1362 6367-6374 CHEBI_PR_EXT:protein denotes protein
T1363 6376-6379 PR_EXT:000007164 denotes XPD
T1364 6386-6395 GO:0010467 denotes expressed
T1365 6410-6416 SO_EXT:0001023 denotes allele
T1366 6436-6444 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1367 6516-6522 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1368 6523-6527 NCBITaxon:10088 denotes mice
T1369 6579-6588 UBERON:0000922 denotes embryonic
T1370 6614-6621 UBERON:0000922 denotes embryos
T1371 6664-6670 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1372 6671-6677 SO_EXT:0001023 denotes allele
T1373 6712-6718 GO_EXT:fatality_or_lethality denotes lethal
T1374 6739-6748 GO_EXT:fatality_or_lethality denotes lethality
T1375 6761-6767 SO_EXT:0001023 denotes allele
T1376 6803-6813 GO:0010467 denotes expression
T1377 6832-6839 CHEBI_PR_EXT:protein denotes protein
T1378 6855-6859 SO_EXT:0000704 denotes gene
T1379 6901-6909 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1380 6918-6921 PR_EXT:000007164 denotes Xpd
T1381 6932-6935 PR_EXT:000007164 denotes Xpd
T1382 6975-6979 UBERON:0000104 denotes life
T1383 7010-7023 GO:0009790 denotes embryogenesis
T1384 7088-7091 PR_EXT:000007164 denotes Xpd
T1385 7092-7100 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T1386 7101-7109 SO_EXT:sequence_coding_function denotes encoding
T1387 7110-7113 PR_EXT:000007164 denotes XPD
T1388 7175-7181 NCBITaxon:9606 denotes humans
T1389 7202-7211 GO:0010467 denotes expressed
T1390 7216-7222 GO_EXT:fatality_or_lethality denotes lethal
T1391 7266-7272 SO_EXT:0001023 denotes allele
T1392 7387-7392 SO_EXT:0000205 denotes 3′UTR
T1393 7412-7415 CHEBI_GO_EXT:neomycin_or_neomycin_phosphotransferase denotes neo
T1394 7416-7420 SO_EXT:0000704 denotes gene
T1395 7450-7453 PR_EXT:000007164 denotes Xpd
T1396 7458-7462 CHEBI_SO_EXT:mRNA denotes mRNA
T1397 7492-7495 PR_EXT:000007164 denotes Xpd
T1398 7506-7509 PR_EXT:000007164 denotes XPD
T1399 7522-7529 NCBITaxon:33208 denotes animals
T1857 9846-9850 SO_EXT:sequence_nullness denotes Null
T1858 9852-9858 SO_EXT:0001023 denotes Allele
T1859 9894-9898 UBERON_EXT:zone_of_skin_or_skin_of_body denotes Skin
T1860 9904-9908 UBERON:0001037 denotes Hair
T1861 9963-9969 GO_EXT:fatality_or_lethality denotes lethal
T1862 9971-9975 SO_EXT:sequence_nullness denotes null
T1863 9977-9983 SO_EXT:0001023 denotes allele
T1864 10014-10024 NCBITaxon:1 denotes organismal
T1865 10051-10054 PR_EXT:000007164 denotes Xpd
T1866 10060-10066 SO_EXT:0001023 denotes allele
T1867 10081-10084 PR_EXT:000007164 denotes Xpd
T1868 10088-10094 SO_EXT:0001023 denotes allele
T1869 10138-10145 NCBITaxon:33208 denotes animals
T1870 10173-10177 NCBITaxon:10088 denotes mice
T1871 10196-10199 PR_EXT:000007164 denotes Xpd
T1872 10209-10215 SO_EXT:0001023 denotes allele
T1873 10217-10220 PR_EXT:000007164 denotes Xpd
T1874 10251-10254 PR_EXT:000007164 denotes Xpd
T1875 10264-10268 NCBITaxon:10088 denotes mice
T1876 10274-10278 GO:0007567 denotes born
T1877 10318-10328 GO:0010467 denotes Expression
T1878 10338-10341 PR_EXT:000007164 denotes Xpd
T1879 10347-10353 SO_EXT:0001023 denotes allele
T1880 10378-10384 UBERON:0000473 denotes testis
T1881 10410-10417 NCBITaxon:33208 denotes animals
T1882 10427-10437 GO:0010467 denotes expression
T1883 10447-10450 PR_EXT:000007164 denotes Xpd
T1884 10454-10460 SO_EXT:0001023 denotes allele
T1885 10487-10489 SO_EXT:wild_type_entity_or_quality denotes wt
T1886 10545-10555 GO:0042571 denotes antibodies
T1887 10605-10611 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T1888 10621-10624 PR_EXT:000007164 denotes XPD
T1889 10650-10660 CHEBI_SO_EXT:amino_acid denotes amino acid
T1890 10661-10674 SO_EXT:sequence_substitution_entity_or_process denotes substitutions
T1891 10727-10730 PR_EXT:000007164 denotes XPD
T1892 10731-10738 CHEBI_PR_EXT:protein denotes protein
T1893 10758-10765 SO_EXT:0001023 denotes alleles
T1894 10793-10797 CHEBI_SO_EXT:mRNA denotes mRNA
T1895 10798-10808 GO:0010467 denotes expression
T1896 10825-10831 GO_EXT:fatality_or_lethality denotes lethal
T1897 10832-10835 PR_EXT:000007164 denotes Xpd
T1898 10841-10847 SO_EXT:0001023 denotes allele
T1899 10869-10872 PR_EXT:000007164 denotes Xpd
T1900 10929-10932 PR_EXT:000007164 denotes Xpd
T1901 10942-10949 NCBITaxon:33208 denotes animals
T1902 10981-10985 UBERON:0001037 denotes hair
T1903 10990-10999 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T1904 11053-11057 NCBITaxon:10088 denotes mice
T1905 11096-11099 PR_EXT:000007164 denotes Xpd
T1906 11112-11115 PR_EXT:000007164 denotes Xpd
T1907 11123-11127 NCBITaxon:10088 denotes mice
T1908 11152-11156 UBERON:0001037 denotes hair
T1909 11175-11179 UBERON:0001037 denotes hair
T1910 11175-11185 GO:0042633 denotes hair cycle
T1911 11198-11202 UBERON:0001037 denotes hair
T1912 11246-11251 UBERON:0000104 denotes lives
T1953 13760-13764 NCBITaxon:10088 denotes mice
T2516 0-6 SO_EXT:sequence_rescue_process denotes Rescue
T2517 13822-13826 NCBITaxon:10088 denotes Mice
T2518 13841-13847 GO_EXT:fatality_or_lethality denotes Lethal
T2519 13848-13851 PR_EXT:000007164 denotes Xpd
T2520 13852-13859 SO_EXT:0001023 denotes Alleles
T2521 13935-13940 NCBITaxon:10088 denotes mouse
T2522 14026-14032 GO:0007568 denotes ageing
T2523 14077-14081 NCBITaxon:10088 denotes mice
T2524 14102-14105 PR_EXT:000007164 denotes Xpd
T2525 14113-14120 NCBITaxon:33208 denotes animals
T2526 14134-14138 UBERON_EXT:bone_element_or_tissue denotes bone
T2527 14139-14146 CHEBI:46662 denotes mineral
T2528 14234-14238 UBERON:0002415 denotes tail
T2529 14239-14248 UBERON:0002412 denotes vertebrae
T2530 14276-14279 PR_EXT:000007164 denotes Xpd
T2531 14289-14293 NCBITaxon:10088 denotes mice
T2532 14313-14315 SO_EXT:wild_type_entity_or_quality denotes wt
T2533 14378-14381 PR_EXT:000007164 denotes Xpd
T2534 14389-14393 NCBITaxon:10088 denotes mice
T2535 14426-14428 SO_EXT:wild_type_entity_or_quality denotes wt
T2536 14429-14436 NCBITaxon:33208 denotes animals
T2537 14490-14493 PR_EXT:000007164 denotes Xpd
T2538 14503-14507 NCBITaxon:10088 denotes mice
T2567 16781-16788 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T2568 16815-16817 SO_EXT:wild_type_entity_or_quality denotes wt
T2569 16845-16847 SO_EXT:wild_type_entity_or_quality denotes wt
T2570 16877-16886 UBERON:0000104 denotes life span
T2571 16955-16962 SO_EXT:0001023 denotes alleles
T3203 18375-18378 PR_EXT:000007164 denotes Xpd
T3167 17108-17117 CHEBI_EXT:polyatomic_entity_or_group denotes Molecular
T3168 17134-17141 SO_EXT:0001023 denotes allelic
T3169 17177-17185 CL_GO_EXT:cell denotes cellular
T3170 17215-17218 CHEBI_SO_EXT:DNA denotes DNA
T3171 17215-17228 GO:0071897 denotes DNA synthesis
T3172 17272-17275 CHEBI_SO_EXT:RNA denotes RNA
T3173 17272-17285 GO:0032774 denotes RNA synthesis
T3174 17354-17357 GO:0006289 denotes NER
T3175 17378-17384 SO_EXT:0001026 denotes genome
T3176 17385-17388 GO:0006289 denotes NER
T3177 17393-17418 GO:0006283 denotes transcription-coupled NER
T3178 17430-17433 GO:0006289 denotes NER
T3179 17481-17489 GO_EXT:reaction_or_response denotes response
T3180 17644-17647 PR_EXT:000007164 denotes Xpd
T3181 17659-17662 PR_EXT:000007164 denotes Xpd
T3182 17669-17676 NCBITaxon:33208 denotes animals
T3183 17701-17704 PR_EXT:000007164 denotes Xpd
T3184 17789-17797 CL_GO_EXT:cell denotes cellular
T3185 17824-17835 CL:0000057 denotes fibroblasts
T3186 17911-17919 NCBITaxon:1 denotes organism
T3187 17921-17924 PR_EXT:000007164 denotes Xpd
T3188 17942-17947 CL_GO_EXT:cell denotes cells
T3189 18037-18042 CL_GO_EXT:cell denotes cells
T3190 18056-18059 PR_EXT:000007164 denotes Xpd
T3191 18077-18082 CL_GO_EXT:cell denotes cells
T3192 18127-18133 GO_EXT:fatality_or_lethality denotes lethal
T3193 18134-18137 PR_EXT:000007164 denotes Xpd
T3194 18143-18149 SO_EXT:0001023 denotes allele
T3195 18153-18156 PR_EXT:000007164 denotes Xpd
T3196 18188-18193 CL_GO_EXT:cell denotes cells
T3197 18224-18227 PR_EXT:000007164 denotes Xpd
T3198 18231-18237 SO_EXT:0001023 denotes allele
T3199 18262-18271 UBERON:0000922 denotes embryonic
T3200 18276-18284 CL_GO_EXT:cell denotes cellular
T3201 18285-18294 GO_EXT:fatality_or_lethality denotes lethality
T3202 18363-18366 PR_EXT:000007164 denotes Xpd
T3204 18382-18389 SO_EXT:0001023 denotes alleles
T3205 18411-18414 PR_EXT:000007164 denotes XPD
T3206 18418-18421 PR_EXT:000007164 denotes XPD
T3207 18443-18446 PR_EXT:000007164 denotes XPD
T3208 18452-18455 PR_EXT:000007164 denotes XPD
T3209 18462-18467 NCBITaxon:9606 denotes human
T3210 18468-18473 CL_GO_EXT:cell denotes cells
T3211 18529-18534 CL_GO_EXT:cell denotes cells
T3212 18560-18563 PR_EXT:000007164 denotes Xpd
T3213 18574-18577 PR_EXT:000007164 denotes XPD
T3214 18590-18595 NCBITaxon:10088 denotes mouse
T3215 18655-18658 PR_EXT:000007164 denotes Xpd
T3216 18673-18676 PR_EXT:000007164 denotes Xpd
T3217 18685-18690 CL_GO_EXT:cell denotes cells
T3218 18747-18753 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3219 18754-18760 SO_EXT:0001023 denotes allele
T3220 18844-18847 GO:0006289 denotes NER
T3221 18872-18875 PR_EXT:000007164 denotes Xpd
T3222 18882-18887 CL_GO_EXT:cell denotes cells
T3223 18905-18908 PR_EXT:000007164 denotes Xpd
T3224 18916-18921 CL_GO_EXT:cell denotes cells
T3267 22843-22854 CL:0000057 denotes fibroblasts
T3268 22910-22915 NCBITaxon:9606 denotes human
T3269 22958-22962 SO_EXT:0000704 denotes gene
T3270 23011-23013 SO_EXT:wild_type_entity_or_quality denotes wt
T3271 23047-23050 PR_EXT:000007164 denotes Xpd
T3272 23057-23062 CL_GO_EXT:cell denotes cells
T3273 23084-23088 CHEBI_SO_EXT:mRNA denotes mRNA
T3274 23089-23099 GO:0010467 denotes expression
T3275 23120-23123 PR_EXT:000007164 denotes Xpd
T3276 23137-23140 PR_EXT:000007164 denotes Xpd
T3277 23144-23150 SO_EXT:0001023 denotes allele
T3278 23171-23176 GO:0005675 denotes TFIIH
T3279 23190-23192 SO_EXT:wild_type_entity_or_quality denotes wt
T3280 23203-23206 PR_EXT:000007164 denotes Xpd
T3281 23232-23237 CL_GO_EXT:cell denotes cells
T3282 23323-23328 CL_GO_EXT:cell denotes cells
T3283 23356-23362 SO_EXT:sequence_rescue_process denotes rescue
T3284 23433-23438 GO:0005675 denotes TFIIH
T3285 23566-23570 CHEBI_SO_EXT:mRNA denotes mRNA
T3286 23571-23581 GO:0010467 denotes expression
T3287 23612-23619 SO_EXT:sequence_coding_function denotes encoded
T3288 23620-23627 CHEBI_PR_EXT:protein denotes protein
T3289 23629-23632 PR_EXT:000007164 denotes XPD
T3290 23658-23662 UBERON:0001037 denotes hair
T3291 23693-23696 PR_EXT:000007164 denotes Xpd
T3292 23707-23714 NCBITaxon:33208 denotes animals
T3293 23733-23737 UBERON:0001037 denotes hair
T3294 23780-23783 PR_EXT:000007164 denotes Xpd
T3295 23789-23799 GO:0010467 denotes expression
T3296 23809-23812 PR_EXT:000007164 denotes Xpd
T3297 23821-23828 NCBITaxon:33208 denotes animals
T3298 23833-23835 SO_EXT:wild_type_entity_or_quality denotes wt
T3299 23836-23840 UBERON:0001037 denotes hair
T3300 23866-23876 GO:0010467 denotes expression
T3301 23900-23903 PR_EXT:000007164 denotes Xpd
T3302 23908-23914 SO_EXT:0001023 denotes allele
T3303 23966-23976 GO:0010467 denotes expression
T4225 24267-24274 SO_EXT:0001023 denotes allelic
T4226 24376-24383 SO_EXT:0001023 denotes allelic
T4227 24422-24428 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4228 24429-24436 SO_EXT:0001023 denotes alleles
T4229 24592-24599 SO_EXT:0000704 denotes genetic
T4230 24622-24633 SO_EXT:0000704 denotes genetically
T4231 24642-24651 NCBITaxon:40674 denotes mammalian
T4232 24796-24803 SO_EXT:sequence_alteration_process denotes mutated
T4233 24804-24807 PR_EXT:000007164 denotes Xpd
T4234 24808-24815 SO_EXT:0001023 denotes alleles
T4235 24832-24839 SO_EXT:0001023 denotes allelic
T4236 24895-24901 SO_EXT:0001023 denotes allele
T4237 24962-24964 SO_EXT:wild_type_entity_or_quality denotes wt
T4238 25040-25045 NCBITaxon:9606 denotes human
T4239 25079-25082 PR_EXT:000007164 denotes Xpd
T4240 25083-25090 SO_EXT:0001023 denotes alleles
T4241 25113-25115 SO_EXT:wild_type_entity_or_quality denotes wt
T4242 25201-25208 SO_EXT:0001023 denotes alleles
T4243 25261-25268 SO_EXT:0001023 denotes alleles
T4244 25332-25340 CHEBI_PR_EXT:protein denotes proteins
T4245 25447-25456 NCBITaxon:1 denotes organisms
T4246 25467-25473 NCBITaxon:9606 denotes humans
T4247 25528-25534 NCBITaxon:33208 denotes animal
T4248 25540-25543 PR_EXT:000007164 denotes Xpd
T4249 25544-25551 SO_EXT:0001023 denotes allelic
T4250 25694-25700 UBERON:0000479 denotes tissue
T4251 25765-25772 SO_EXT:0001023 denotes allelic
T4252 25795-25802 SO_EXT:0001023 denotes allelic
T4253 25824-25830 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T4254 25831-25838 SO_EXT:0001023 denotes alleles
T4255 25870-25872 SO_EXT:wild_type_entity_or_quality denotes wt
T4256 25982-25989 SO_EXT:0001023 denotes allelic
T4257 26028-26031 PR_EXT:000007164 denotes Xpd
T4258 26076-26080 UBERON:0001037 denotes hair
T4696 26105-26110 GO:0005675 denotes TFIIH
T4697 26114-26127 GO_EXT:transcription denotes Transcription
T4698 26132-26138 GO:0006281 denotes Repair
T4699 26154-26157 PR_EXT:000007164 denotes XPD
T4700 26219-26222 PR_EXT:000007164 denotes Xpd
T4701 26244-26250 GO_EXT:fatality_or_lethality denotes lethal
T4702 26251-26254 PR_EXT:000007164 denotes Xpd
T4703 26264-26267 PR_EXT:000007164 denotes Xpd
T4704 26271-26278 SO_EXT:0001023 denotes alleles
T4705 26298-26311 GO_EXT:transcription denotes transcription
T4706 26348-26356 NCBITaxon:1 denotes organism
T4707 26381-26390 UBERON:0000922 denotes embryonic
T4708 26391-26400 GO_EXT:fatality_or_lethality denotes lethality
T4709 26414-26432 _FRAGMENT denotes differentiation of
T4710 26460-26465 GO:0030154 denotes cells
T4711 26433-26444 GO:0090601 denotes enucleating
T4712 26433-26444 _FRAGMENT denotes enucleating
T4713 26460-26465 CL:0000225 denotes cells
T4714 26445-26449 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T4715 26454-26459 UBERON:0000178 denotes blood
T4716 26454-26465 CL:0000081 denotes blood cells
T4717 26460-26465 CL_GO_EXT:cell denotes cells
T4718 26474-26484 UBERON:0000358 denotes blastocyst
T4719 26502-26511 GO_EXT:fatality_or_lethality denotes lethality
T4720 26526-26529 PR_EXT:000007164 denotes Xpd
T4721 26533-26536 PR_EXT:000007164 denotes Xpd
T4722 26547-26550 PR_EXT:000007164 denotes Xpd
T4723 26554-26561 SO_EXT:0001023 denotes alleles
T4724 26601-26614 GO_EXT:transcription denotes transcription
T4725 26641-26645 UBERON:0000104 denotes life
T4726 26650-26653 PR_EXT:000007164 denotes Xpd
T4727 26668-26671 PR_EXT:000007164 denotes Xpd
T4728 26702-26706 NCBITaxon:10088 denotes mice
T4729 26708-26717 UBERON:0000922 denotes embryonic
T4730 26718-26727 GO_EXT:fatality_or_lethality denotes lethality
T4731 26738-26745 SO_EXT:sequence_rescue_process denotes rescued
T4732 26753-26756 PR_EXT:000007164 denotes Xpd
T4733 26760-26766 SO_EXT:0001023 denotes allele
T4734 26776-26785 UBERON:0000922 denotes embryonic
T4735 26786-26795 GO_EXT:fatality_or_lethality denotes lethality
T4736 26811-26818 SO_EXT:sequence_rescue_process denotes rescued
T4737 26822-26825 PR_EXT:000007164 denotes Xpd
T4738 26843-26847 NCBITaxon:10088 denotes mice
T4739 26853-26856 PR_EXT:000007164 denotes Xpd
T4740 26860-26866 SO_EXT:0001023 denotes allele
T4741 26888-26890 SO_EXT:wild_type_entity_or_quality denotes wt
T4742 26935-26941 GO_EXT:fatality_or_lethality denotes lethal
T4743 26942-26949 SO_EXT:0001023 denotes alleles
T4744 26951-26954 PR_EXT:000007164 denotes Xpd
T4745 26958-26961 PR_EXT:000007164 denotes Xpd
T4746 26972-26975 PR_EXT:000007164 denotes Xpd
T4747 27046-27055 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T4748 27143-27158 GO_EXT:transcription denotes transcriptional
T4749 27205-27210 GO:0005675 denotes TFIIH
T4750 27231-27249 _FRAGMENT denotes differentiation of
T4751 27278-27283 GO:0030154 denotes cells
T4752 27250-27254 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T4753 27256-27266 UBERON:0002074 denotes hair-shaft
T4754 27256-27266 _FRAGMENT denotes hair-shaft
T4755 27278-27283 CL:0002559 denotes cells
T4756 27272-27277 UBERON:0000178 denotes blood
T4757 27272-27283 CL:0000081 denotes blood cells
T4758 27278-27283 CL_GO_EXT:cell denotes cells
T4759 27318-27322 NCBITaxon:10088 denotes mice
T4760 27340-27346 GO_EXT:fatality_or_lethality denotes lethal
T4761 27347-27350 PR_EXT:000007164 denotes Xpd
T4762 27360-27363 PR_EXT:000007164 denotes Xpd
T4763 27367-27374 SO_EXT:0001023 denotes alleles
T4764 27398-27401 PR_EXT:000007164 denotes Xpd
T4765 27414-27423 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T4766 27490-27493 PR_EXT:000007164 denotes Xpd
T4767 27497-27503 SO_EXT:0001023 denotes allele
T4768 27578-27587 UBERON:0000922 denotes embryonic
T4769 27588-27597 GO_EXT:fatality_or_lethality denotes lethality
T4770 27620-27635 GO_RO_EXT:developmental_differentiation_process denotes differentiation
T4771 27643-27647 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T4772 27649-27653 UBERON:0001037 denotes hair
T4773 27659-27664 UBERON:0000178 denotes blood
T4774 27725-27740 GO_EXT:transcription denotes transcriptional
T4775 27762-27777 UBERON:0019248 denotes early embryonic
T4776 27768-27789 GO:0009790 denotes embryonic development
T4777 27791-27794 PR_EXT:000007164 denotes Xpd
T4778 27819-27822 PR_EXT:000007164 denotes Xpd
T4779 27832-27835 PR_EXT:000007164 denotes Xpd
T4780 27839-27846 SO_EXT:0001023 denotes alleles
T4781 27869-27888 GO:0043588 denotes ontogenesis of skin
T4782 27869-27883 _FRAGMENT denotes ontogenesis of
T4783 27912-27917 GO:0048468 denotes cells
T4784 27884-27888 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T4785 27890-27900 UBERON:0002074 denotes hair-shaft
T4786 27890-27900 _FRAGMENT denotes hair-shaft
T4787 27912-27917 CL:0002559 denotes cells
T4788 27906-27911 UBERON:0000178 denotes blood
T4789 27906-27917 CL:0000081 denotes blood cells
T4790 27912-27917 CL_GO_EXT:cell denotes cells
T4791 27965-27971 GO:0006281 denotes repair
T4792 27996-27999 PR_EXT:000007164 denotes Xpd
T4793 28005-28011 SO_EXT:0001023 denotes allele
T4794 28063-28066 PR_EXT:000007164 denotes Xpd
T4795 28070-28076 SO_EXT:0001023 denotes allele
T4796 28084-28087 PR_EXT:000007164 denotes Xpd
T4797 28092-28099 SO_EXT:0001023 denotes alleles
T4798 28115-28125 GO:0010467 denotes expression
T4799 28164-28171 SO_EXT:0001023 denotes allelic
T4800 28228-28236 CL_GO_EXT:cell denotes cellular
T4801 28240-28251 CHEBI_EXT:biochemical denotes biochemical
T4802 28291-28294 PR_EXT:000007164 denotes Xpd
T4803 28344-28350 GO:0006281 denotes repair
T4804 28367-28373 SO_EXT:sequence_rescue_process denotes rescue
T5259 28415-28422 SO_EXT:0001023 denotes allelic
T5260 28443-28446 PR_EXT:000007164 denotes XPD
T5261 28471-28478 SO_EXT:0001023 denotes allelic
T5262 28526-28529 PR_EXT:000007164 denotes XPD
T5263 28545-28552 SO_EXT:0001023 denotes allelic
T5264 28595-28605 GO:0032991 denotes multimeric
T5265 28606-28614 CHEBI_PR_EXT:protein denotes proteins
T5266 28640-28647 SO_EXT:0000417 denotes domains
T5267 28724-28733 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T5268 28738-28741 PR_EXT:000007164 denotes XPD
T5269 28753-28760 SO_EXT:0000417 denotes domains
T5270 28807-28810 PR_EXT:000007164 denotes XPD
T5271 28844-28849 GO:0005675 denotes TFIIH
T5272 28901-28905 CL_GO_EXT:cell denotes cell
T5273 28951-28956 GO:0005675 denotes TFIIH
T5274 28969-28972 PR_EXT:000007164 denotes XPD
T5275 28977-28980 PR_EXT:000007165 denotes XPB
T5276 28996-28999 GO:0006289 denotes NER
T5277 29042-29047 GO:0005675 denotes TFIIH
T5278 29123-29126 GO:0006289 denotes NER
T5279 29150-29153 PR_EXT:000007164 denotes XPD
T5280 29180-29185 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bound
T5281 29198-29203 GO:0005675 denotes TFIIH
T5282 29231-29240 CHEBI_EXT:polyatomic_entity_or_group denotes molecular
T5283 29259-29266 SO_EXT:0001023 denotes allelic
T5284 29310-29313 PR_EXT:000007164 denotes XPD
T5285 29314-29323 CHEBI:36357 denotes molecules
T5286 29335-29348 GO:0005675 denotes TFIIH complex
T5287 29364-29379 GO:0005675 denotes TFIIH complexes
T5288 29401-29404 PR_EXT:000007164 denotes XPD
T5289 29405-29414 CHEBI:36357 denotes molecules
T5290 29430-29433 CHEBI_SO_EXT:DNA denotes DNA
T5291 29473-29479 SO_EXT:0001026 denotes genome
T5292 29491-29522 _FRAGMENT denotes transcription-coupled repair of
T5293 29555-29565 GO:0006283 denotes DNA damage
T5294 29555-29558 CHEBI_SO_EXT:DNA denotes DNA
T5551 29572-29579 SO_EXT:0001023 denotes allelic
T5552 29593-29596 PR_EXT:000007164 denotes XPD
T5553 29617-29625 CHEBI_PR_EXT:protein denotes proteins
T5554 29652-29656 SO_EXT:sequence_nullness denotes null
T5555 29657-29664 SO_EXT:0001023 denotes alleles
T5556 29670-29683 CHEBI_EXT:biochemical denotes biochemically
T5557 29719-29732 GO_EXT:transcription denotes transcription
T5558 29780-29787 SO_EXT:0001023 denotes alleles
T5559 29798-29804 SO_EXT:sequence_rescue_process denotes rescue
T5560 29805-29814 GO_EXT:fatality_or_lethality denotes lethality
T5561 29826-29834 NCBITaxon:4896 denotes S. pombe
T5562 29842-29846 SO_EXT:sequence_nullness denotes null
T5563 29847-29855 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5564 29863-29866 PR_EXT:000007164 denotes XPD
T5565 29867-29876 SO_EXT:0000853 denotes homologue
T5566 29877-29882 PR_EXT:P26659 denotes rad15
T5567 29928-29932 SO_EXT:sequence_nullness denotes null
T5568 29933-29940 SO_EXT:0001023 denotes alleles
T5569 29988-30001 GO_EXT:transcription denotes transcription
T5570 30085-30091 NCBITaxon:9606 denotes humans
T5571 30107-30112 NCBITaxon:10088 denotes mouse
T5572 30284-30291 SO_EXT:0001023 denotes allelic
T5573 30304-30307 PR_EXT:000007164 denotes XPD
T5574 30360-30363 PR_EXT:000007164 denotes XPD
T5575 30390-30393 PR_EXT:000007164 denotes XPD
T5576 30402-30405 PR_EXT:000007164 denotes XPD
T5577 30411-30419 SO_EXT:sequence_coding_function denotes encoding
T5578 30420-30427 SO_EXT:0001023 denotes alleles
T5579 30432-30436 GO:0016265 denotes died
T5580 30497-30500 PR_EXT:000007164 denotes XPD
T5581 30532-30535 PR_EXT:000007164 denotes XPD
T5582 30544-30547 PR_EXT:000007164 denotes XPD
T5583 30553-30561 SO_EXT:sequence_coding_function denotes encoding
T5584 30562-30569 SO_EXT:0001023 denotes alleles
T5585 30598-30602 SO_EXT:sequence_nullness denotes null
T5586 30603-30606 PR_EXT:000007164 denotes XPD
T5587 30888-30891 PR_EXT:000007164 denotes Xpd
T5588 30905-30908 PR_EXT:000007164 denotes Xpd
T5589 30916-30920 NCBITaxon:10088 denotes mice
T5590 30996-31000 UBERON:0001037 denotes hair
T5591 31001-31009 CHEBI_SO_EXT:cysteine denotes cysteine
T5592 31078-31086 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T5593 31094-31100 SO_EXT:0001023 denotes allele
T5594 31113-31127 SO_EXT:point_mutation_entity_or_process denotes point mutation
T5595 31128-31136 SO_EXT:sequence_coding_function denotes encoding
T5596 31137-31140 PR_EXT:000007164 denotes XPD
T5597 31173-31176 PR_EXT:000007164 denotes XPD
T5598 31182-31190 SO_EXT:sequence_coding_function denotes encoding
T5599 31191-31197 SO_EXT:0001023 denotes allele
T5600 31243-31251 NCBITaxon:4896 denotes S. pombe
T5601 31252-31257 PR_EXT:P26659 denotes rad15
T5602 31258-31266 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T5603 31305-31309 SO_EXT:sequence_nullness denotes null
T5604 31310-31316 SO_EXT:0001023 denotes allele
T5605 31439-31446 SO_EXT:0001023 denotes alleles
T5606 31498-31505 SO_EXT:0001023 denotes allelic
T6008 32389-32396 SO_EXT:0001023 denotes Alleles
T6009 32431-32438 NCBITaxon:40674 denotes Mammals
T6010 32442-32448 NCBITaxon:9606 denotes humans
T6011 32478-32485 SO_EXT:0001023 denotes allelic
T6012 32507-32514 SO_EXT:0001023 denotes allelic
T6013 32562-32569 SO_EXT:0001023 denotes allelic
T6014 32609-32615 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6015 32616-32623 SO_EXT:0001023 denotes alleles
T6016 32646-32651 CL_GO_EXT:cell denotes cells
T6017 32694-32707 CHEBI:30860 denotes methylmalonic
T6018 32941-32948 NCBITaxon:33208 denotes animals
T6019 32957-32964 SO_EXT:0001023 denotes allelic
T6020 32995-33000 NCBITaxon:9606 denotes human
T6021 33042-33049 SO_EXT:0001023 denotes alleles
T6022 33073-33077 PR_EXT:000001044 denotes CTRF
T6023 33078-33082 SO_EXT:0000704 denotes gene
T6024 33108-33117 GO:0030849 denotes autosomal
T6025 33211-33218 SO_EXT:0001023 denotes allelic
T6026 33257-33264 SO_EXT:0001023 denotes allelic
T6027 33301-33310 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T6028 33315-33346 SO_EXT:0000694 denotes single nucleotide polymorphisms
T6029 33322-33332 CHEBI_SO_EXT:nucleotide denotes nucleotide
T6030 33347-33353 SO_EXT:0001026 denotes genome
T6031 33399-33406 SO_EXT:0001023 denotes allelic
T6032 33484-33492 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6033 33522-33531 GO:0030849 denotes autosomal
T6034 33584-33591 NCBITaxon:40674 denotes mammals
T6035 33647-33656 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T6036 33721-33727 SO_EXT:0001023 denotes allele
T6037 33758-33768 SO_EXT:sequence_alteration_entity_or_process denotes alteration
T6038 33835-33842 SO_EXT:0001023 denotes alleles
T6039 33868-33872 SO_EXT:sequence_nullness denotes null
T6040 33903-33913 GO:0010467 denotes expression
T6342 34203-34206 PR_EXT:000007164 denotes Xpd
T6343 34211-34218 SO_EXT:0001023 denotes alleles
T6344 34228-34237 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T6345 34238-34246 SO_EXT:sequence_coding_function denotes encoding
T6346 34267-34278 SO_EXT:sequence_alteration_entity_or_process denotes alterations
T6347 34319-34323 NCBITaxon:10088 denotes mice
T6348 34328-34333 NCBITaxon:10088 denotes mouse
T6349 34334-34343 UBERON:0000922 denotes embryonic
T6350 34344-34355 CL:0000057 denotes fibroblasts
T6351 34405-34417 CHEBI:51686 denotes Haematoxylin
T6352 34422-34427 CHEBI_EXT:eosin denotes eosin
T6353 34485-34495 CHEBI_SO_EXT:amino_acid denotes Amino acid
T6354 34541-34546 UBERON:0000178 denotes Blood
T6355 34574-34580 NCBITaxon:33208 denotes Animal
T6356 34581-34586 UBERON:0000178 denotes Blood
T6357 34675-34679 UBERON_EXT:bone_element_or_tissue denotes bone
T6358 34680-34687 CHEBI:46662 denotes mineral
T6359 34733-34737 NCBITaxon:10088 denotes Mice
T6360 34850-34854 NCBITaxon:10088 denotes mice
T6361 34910-34917 SO_EXT:0000704 denotes genetic
T6362 34936-34945 NCBITaxon:1 denotes organisms
T6363 34954-34960 NCBITaxon:33208 denotes animal
T6758 35836-35850 _FRAGMENT denotes p62 subunit of
T6759 35855-35860 PR_EXT:000008317 denotes TFIIH
T6760 35855-35860 GO:0005675 denotes TFIIH
T6761 35921-35926 NCBITaxon:10088 denotes mouse
T6762 35927-35936 UBERON:0000922 denotes embryonic
T6763 35937-35948 CL:0000057 denotes fibroblasts
T6764 35978-35982 CL_GO_EXT:cell denotes cell
T6765 35993-36001 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6766 36018-36021 PR_EXT:000007164 denotes Xpd
T6767 36029-36034 CL_GO_EXT:cell denotes cells
T6768 36054-36058 CL_GO_EXT:cell denotes cell
T6769 36153-36161 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T6979 7563-7568 NCBITaxon:10088 denotes Mouse
T6980 7569-7572 PR_EXT:000007164 denotes Xpd
T6981 7573-7577 SO_EXT:0000704 denotes Gene
T6982 7614-7621 SO_EXT:0001026 denotes genomic
T6983 7644-7659 SO_EXT:0001250 denotes restriction map
T6984 7667-7669 SO_EXT:wild_type_entity_or_quality denotes wt
T6985 7683-7688 NCBITaxon:10088 denotes mouse
T6986 7689-7692 PR_EXT:000007164 denotes Xpd
T6987 7707-7709 SO_EXT:wild_type_entity_or_quality denotes wt
T6988 7710-7713 PR_EXT:000007164 denotes Xpd
T6989 7714-7720 SO_EXT:0001023 denotes allele
T6990 7745-7768 SO_EXT:0001215 denotes coding regions of exons
T6991 7787-7792 SO_EXT:0000205 denotes 3′UTR
T6992 7842-7860 GO:0006415 denotes translational stop
T6993 7842-7866 SO_EXT:0000319 denotes translational stop codon
T6994 7868-7873 SO_EXT:0000551 denotes PolyA
T6995 7888-7903 GO:0043631 denotes polyadenylation
T6996 7888-7910 SO_EXT:0000551 denotes polyadenylation signal
T6997 7920-7923 PR_EXT:000007164 denotes Xpd
T6998 7936-7942 SO_EXT:0001023 denotes allele
T6999 7952-7956 CHEBI_SO_EXT:base denotes base
T7000 7952-7961 SO_EXT:0000028 denotes base pair
T7001 7963-7965 SO_EXT:0000028 denotes bp
T7002 7967-7972 NCBITaxon:9606 denotes human
T7003 7973-7976 PR_EXT:000007164 denotes XPD
T7004 7977-7981 SO_EXT:cDNA denotes cDNA
T7005 7991-7996 SO_EXT:sequence_fusion_process denotes fused
T7006 8000-8004 SO_EXT:0000147 denotes exon
T7007 8064-8072 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T7008 8104-8111 NCBITaxon:9031 denotes Chicken
T7009 8112-8120 PR_EXT:000008457 denotes β-globin
T7010 8114-8120 CHEBI:5386 denotes globin
T7011 8121-8126 SO_EXT:0000147 denotes exons
T7012 8149-8154 SO_EXT:0000205 denotes 3′UTR
T7013 8234-8242 PR_EXT:000008457 denotes β-globin
T7014 8236-8242 CHEBI:5386 denotes globin
T7015 8243-8258 GO:0043631 denotes polyadenylation
T7016 8243-8265 SO_EXT:0000551 denotes polyadenylation signal
T7017 8267-8273 SO_EXT:0000551 denotes PolyA*
T7018 8284-8287 PR_EXT:000007164 denotes Xpd
T7019 8295-8298 PR_EXT:000007164 denotes Xpd
T7020 8313-8320 SO_EXT:0001023 denotes alleles
T7021 8359-8367 SO_EXT:sequence_coding_function denotes encoding
T7022 8383-8391 SO_EXT:sequence_coding_function denotes encoding
T7023 8393-8402 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T7024 8406-8411 SO_EXT:0000147 denotes exons
T7025 8451-8456 CHEBI_SO_EXT:molecular_probe denotes probe
T7026 8487-8496 SO_EXT:engineered_biological_sequence denotes construct
T7027 8530-8547 SO_EXT:0000061 denotes Restriction sites
T7028 8549-8550 PR_EXT:P23940 denotes B
T7029 8552-8557 PR_EXT:P23940 denotes BamHI
T7030 8578-8579 PR_EXT:P43870 denotes H
T7031 8581-8588 PR_EXT:P43870 denotes HindIII
T7032 8655-8666 SO_EXT:genomic_DNA denotes genomic DNA
T7033 8663-8666 CHEBI_SO_EXT:DNA denotes DNA
T7034 8672-8674 SO_EXT:wild_type_entity_or_quality denotes wt
T7035 8676-8679 PR_EXT:000007164 denotes Xpd
T7036 8685-8687 SO_EXT:wild_type_entity_or_quality denotes wt
T7037 8693-8696 PR_EXT:000007164 denotes Xpd
T7038 8700-8702 SO_EXT:wild_type_entity_or_quality denotes wt
T7039 8703-8714 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T7040 8715-8724 UBERON:0000922 denotes embryonic
T7041 8715-8734 CL:0002322 denotes embryonic stem cell
T7042 8730-8734 CL_GO_EXT:cell denotes cell
T7043 8735-8741 SO_EXT:sequence_cloned_entity denotes clones
T7044 8742-8752 GO:0097617 denotes hybridised
T7045 8765-8770 CHEBI_SO_EXT:molecular_probe denotes probe
T7046 8792-8794 SO_EXT:wild_type_entity_or_quality denotes wt
T7047 8795-8801 SO_EXT:0001023 denotes allele
T7048 8819-8823 CHEBI_SO_EXT:base denotes base
T7049 8826-8827 CHEBI_SO_EXT:base denotes b
T7050 8861-8864 PR_EXT:000007164 denotes Xpd
T7051 8872-8875 PR_EXT:000007164 denotes Xpd
T7052 8881-8888 SO_EXT:0001023 denotes alleles
T7053 8902-8903 CHEBI_SO_EXT:base denotes b
T7054 8932-8934 SO_EXT:wild_type_entity_or_quality denotes wt
T7055 8948-8955 SO_EXT:0001023 denotes alleles
T7056 8969-8976 SO_EXT:0000112 denotes primers
T7057 9036-9038 SO_EXT:0000028 denotes bp
T7058 9047-9049 SO_EXT:0000028 denotes bp
T7059 9069-9071 GO_EXT:reverse_transcription_or_reverse_transcriptase denotes RT
T7060 9089-9093 CHEBI_SO_EXT:mRNA denotes mRNA
T7061 9094-9104 GO:0010467 denotes expression
T7062 9149-9156 SO_EXT:0001023 denotes alleles
T7063 9160-9169 UBERON:0000922 denotes embryonic
T7064 9160-9179 CL:0002322 denotes embryonic stem cell
T7065 9175-9179 CL_GO_EXT:cell denotes cell
T7066 9180-9186 SO_EXT:sequence_cloned_entity denotes clones
T7067 9193-9200 SO_EXT:0000112 denotes primers
T7068 9205-9216 GO:0097617 denotes hybridising
T7069 9239-9248 SO_EXT:engineered_biological_sequence denotes construct
T7070 9296-9298 SO_EXT:0000028 denotes bp
T7071 9345-9348 CHEBI_SO_EXT:RNA denotes RNA
T7072 9363-9369 UBERON:0000473 denotes testis
T7073 9384-9386 SO_EXT:wild_type_entity_or_quality denotes wt
T7074 9391-9394 PR_EXT:000007164 denotes Xpd
T7075 9416-9419 PR_EXT:000007164 denotes Xpd
T7076 9425-9427 SO_EXT:wild_type_entity_or_quality denotes wt
T7077 9439-9441 SO_EXT:wild_type_entity_or_quality denotes wt
T7078 9469-9472 PR_EXT:000007164 denotes Xpd
T7079 9482-9486 NCBITaxon:10088 denotes mice
T7080 9501-9514 GO:0097617 denotes Hybridisation
T7081 9527-9528 CHEBI_SO_EXT:base denotes b
T7082 9529-9534 NCBITaxon:10088 denotes mouse
T7083 9535-9538 PR_EXT:000007164 denotes Xpd
T7084 9539-9543 SO_EXT:cDNA denotes cDNA
T7085 9544-9549 CHEBI_SO_EXT:molecular_probe denotes probe
T7086 9558-9563 CHEBI_SO_EXT:mRNA denotes mRNAs
T7087 9584-9585 CHEBI_SO_EXT:base denotes b
T7088 9591-9593 SO_EXT:wild_type_entity_or_quality denotes wt
T7089 9595-9598 PR_EXT:000007164 denotes Xpd
T7090 9609-9612 PR_EXT:000007164 denotes Xpd
T7091 9616-9623 SO_EXT:0001023 denotes alleles
T7092 9642-9658 CHEBI:4883 denotes ethidium bromide
T7093 9660-9664 CHEBI:4883 denotes EtBr
T7094 9706-9709 CHEBI_SO_EXT:RNA denotes RNA
T7616 11945-11951 SO_EXT:sequence_rescue_process denotes Rescue
T7617 11959-11968 UBERON_EXT:zone_of_skin_or_skin_of_body denotes Cutaneous
T7618 11970-11975 UBERON:0000178 denotes Blood
T7619 12031-12034 PR_EXT:000007164 denotes Xpd
T7620 12044-12048 NCBITaxon:10088 denotes Mice
T7621 12088-12091 PR_EXT:000007164 denotes Xpd
T7622 12122-12125 PR_EXT:000007164 denotes Xpd
T7623 12140-12142 SO_EXT:wild_type_entity_or_quality denotes wt
T7624 12143-12147 NCBITaxon:10088 denotes mice
T7625 12179-12183 UBERON:0001037 denotes hair
T7626 12223-12227 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T7627 12231-12234 PR_EXT:000007164 denotes Xpd
T7628 12243-12246 PR_EXT:000007164 denotes Xpd
T7629 12261-12263 SO_EXT:wild_type_entity_or_quality denotes wt
T7630 12264-12268 NCBITaxon:10088 denotes mice
T7631 12305-12314 UBERON:0007376 denotes epidermis
T7632 12404-12419 UBERON:0001821 denotes sebacious gland
T7633 12487-12496 UBERON:0007376 denotes epidermis
T7634 12500-12503 PR_EXT:000007164 denotes Xpd
T7635 12517-12519 SO_EXT:wild_type_entity_or_quality denotes wt
T7636 12520-12524 NCBITaxon:10088 denotes mice
T7637 12550-12558 CHEBI_SO_EXT:cysteine denotes Cysteine
T7638 12570-12574 UBERON:0001037 denotes hair
T7639 12580-12582 SO_EXT:wild_type_entity_or_quality denotes wt
T7640 12584-12587 PR_EXT:000007164 denotes Xpd
T7641 12600-12603 PR_EXT:000007164 denotes Xpd
T7642 12613-12617 NCBITaxon:10088 denotes mice
T7643 12673-12680 SO_EXT:sequence_altered_entity denotes mutants
T7644 12685-12687 SO_EXT:wild_type_entity_or_quality denotes wt
T7645 12708-12711 PR_EXT:000007164 denotes Xpd
T7646 12723-12726 PR_EXT:000007164 denotes Xpd
T7647 12736-12740 NCBITaxon:10088 denotes mice
T7648 12823-12828 UBERON:0000178 denotes blood
T7649 12832-12835 PR_EXT:000007164 denotes Xpd
T7650 12847-12850 PR_EXT:000007164 denotes Xpd
T7651 12860-12864 NCBITaxon:10088 denotes mice
T7652 12935-12937 SO_EXT:wild_type_entity_or_quality denotes wt
T7653 12968-12972 UBERON_EXT:body denotes Body
T7654 12995-12998 PR_EXT:000007164 denotes Xpd
T7655 13010-13013 PR_EXT:000007164 denotes Xpd
T7656 13023-13027 NCBITaxon:10088 denotes mice
T7657 13103-13105 SO_EXT:wild_type_entity_or_quality denotes wt
T7989 14852-14858 SO_EXT:sequence_rescue_process denotes Rescue
T7990 14931-14934 PR_EXT:000007164 denotes Xpd
T7991 14945-14949 NCBITaxon:10088 denotes Mice
T7992 14979-14981 SO_EXT:wild_type_entity_or_quality denotes wt
T7993 15005-15008 PR_EXT:000007164 denotes Xpd
T7994 15034-15037 PR_EXT:000007164 denotes Xpd
T7995 15045-15049 NCBITaxon:10088 denotes mice
T7996 15086-15102 UBERON:0002190 denotes subcutaneous fat
T7997 15111-15114 PR_EXT:000007164 denotes Xpd
T7998 15122-15127 NCBITaxon:10088 denotes mouse
T7999 15165-15167 SO_EXT:wild_type_entity_or_quality denotes wt
T8000 15172-15175 PR_EXT:000007164 denotes Xpd
T8001 15185-15189 NCBITaxon:10088 denotes mice
T8002 15220-15224 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T8003 15225-15227 SO_EXT:wild_type_entity_or_quality denotes wt
T8004 15229-15232 PR_EXT:000007164 denotes Xpd
T8005 15247-15250 PR_EXT:000007164 denotes Xpd
T8006 15258-15262 NCBITaxon:10088 denotes mice
T8007 15264-15270 GO:0007568 denotes Ageing
T8008 15271-15274 PR_EXT:000007164 denotes Xpd
T8009 15282-15286 NCBITaxon:10088 denotes mice
T8010 15322-15335 UBERON:0001130 denotes spinal column
T8011 15354-15358 UBERON_EXT:bone_element_or_tissue denotes bone
T8012 15359-15366 CHEBI:46662 denotes mineral
T8013 15410-15414 UBERON:0002415 denotes tail
T8014 15415-15424 UBERON:0002412 denotes vertebrae
T8015 15442-15448 UBERON:0002355 denotes pelvis
T8016 15516-15519 PR_EXT:000007164 denotes Xpd
T8017 15532-15537 NCBITaxon:10088 denotes mouse
T8018 15570-15574 UBERON_EXT:bone_element_or_tissue denotes bone
T8019 15575-15582 CHEBI:46662 denotes mineral
T8020 15594-15598 UBERON:0002415 denotes tail
T8021 15599-15608 UBERON:0002412 denotes vertebrae
T8022 15624-15628 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T8023 15629-15631 SO_EXT:wild_type_entity_or_quality denotes wt
T8024 15641-15644 PR_EXT:000007164 denotes Xpd
T8025 15667-15670 PR_EXT:000007164 denotes Xpd
T8026 15686-15690 NCBITaxon:10088 denotes mice
T8027 15761-15764 PR_EXT:000007164 denotes Xpd
T8028 15802-15806 UBERON_EXT:body denotes Body
T8029 15893-15896 PR_EXT:000007164 denotes Xpd
T8030 15904-15908 NCBITaxon:10088 denotes mice
T8031 15913-15920 SO_EXT:sequence_rescue_process denotes rescued
T8032 15929-15933 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T8033 15938-15944 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T8034 15945-15948 PR_EXT:000007164 denotes Xpd
T8035 15960-15964 NCBITaxon:10088 denotes mice
T8036 15998-16000 SO_EXT:wild_type_entity_or_quality denotes wt
T8037 16005-16008 PR_EXT:000007164 denotes Xpd
T8038 16032-16034 SO_EXT:wild_type_entity_or_quality denotes wt
T8039 16039-16042 PR_EXT:000007164 denotes Xpd
T8040 16052-16056 NCBITaxon:10088 denotes mice
T8463 19446-19451 GO:0005675 denotes TFIIH
T8464 19480-19483 PR_EXT:000007164 denotes XPD
T8465 19518-19526 CL_GO_EXT:cell denotes Cellular
T8466 19558-19564 SO_EXT:sequence_rescue_process denotes Rescue
T8467 19579-19582 PR_EXT:000007164 denotes Xpd
T8468 19601-19604 PR_EXT:000007164 denotes Xpd
T8469 19614-19617 PR_EXT:000007164 denotes Xpd
T8470 19621-19628 SO_EXT:0001023 denotes alleles
T8471 19710-19713 PR_EXT:000007164 denotes Xpd
T8472 19723-19728 CL_GO_EXT:cell denotes cells
T8473 19758-19767 GO:0010467 denotes expressed
T8474 19775-19781 SO_EXT:0001023 denotes allele
T8475 19783-19786 PR_EXT:000007164 denotes Xpd
T8476 19896-19900 CL_GO_EXT:cell denotes cell
T8477 19911-19919 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T8478 20031-20037 SO_EXT:0001026 denotes genome
T8479 20038-20044 GO:0006281 denotes repair
T8480 20077-20080 PR_EXT:000007164 denotes Xpd
T8481 20097-20100 PR_EXT:000007164 denotes Xpd
T8482 20116-20119 PR_EXT:000007164 denotes Xpd
T8483 20139-20142 PR_EXT:000007164 denotes Xpd
T8484 20157-20161 CL_GO_EXT:cell denotes cell
T8485 20172-20180 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T8486 20266-20269 PR_EXT:000007164 denotes Xpd
T8487 20324-20327 PR_EXT:000007164 denotes Xpd
T8488 20360-20388 GO:0006283 denotes transcription-coupled repair
T8489 20442-20445 PR_EXT:000007164 denotes Xpd
T8490 20462-20465 PR_EXT:000007164 denotes Xpd
T8491 20481-20484 PR_EXT:000007164 denotes Xpd
T8492 20504-20507 PR_EXT:000007164 denotes Xpd
T8493 20522-20526 CL_GO_EXT:cell denotes cell
T8494 20537-20545 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T8495 20584-20592 MOP:0000780 denotes Incision
T8496 20593-20601 SO_EXT:sequence_deletion_process denotes excision
T8497 20630-20637 SO_EXT:sequence_alteration_process denotes altered
T8498 20638-20653 GO:0005675 denotes TFIIH complexes
T8499 20673-20676 GO:0006289 denotes NER
T8500 20735-20746 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T8501 20747-20753 GO:0005675 denotes TFIIHs
T8502 20766-20769 PR_EXT:000007164 denotes XPD
T8503 20771-20774 PR_EXT:000007165 denotes XPB
T8504 20776-20779 PR_EXT:000008317 denotes p62
T8505 20781-20784 PR_EXT:000008320 denotes p52
T8506 20786-20789 CHEBI_SO_EXT:histidine denotes His
T8507 20790-20793 PR_EXT:000008318 denotes p44
T8508 20800-20803 PR_EXT:000008319 denotes p34
T8509 20805-20809 PR_EXT:000005265 denotes cdk7
T8510 20811-20819 PR_EXT:000005130 denotes cyclin H
T8511 20821-20825 PR_EXT:000010496 denotes Mat1
T8512 20831-20833 PR_EXT:000008321 denotes p8
T8513 20851-20862 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T8514 20863-20866 PR_EXT:000007167 denotes XPG
T8515 20868-20871 PR_EXT:000007166 denotes XPF
T8516 20872-20877 PR_EXT:000007163 denotes ERCC1
T8517 20879-20882 PR_EXT:000017494 denotes XPC
T8518 20883-20889 PR_EXT:000013670 denotes hHR23B
T8519 20891-20894 GO:0005662 denotes RPA
T8520 20902-20915 CHEBI_EXT:radiolabel_process denotes radiolabelled
T8521 20926-20929 GO:0006289 denotes NER
T8522 20945-20953 SO_EXT:sequence_deletion_process denotes excision
T8523 20970-20981 CHEBI_SO_EXT:nucleotide denotes nucleotides
T8524 21012-21022 CHEBI_SO_EXT:nucleotide denotes nucleotide
T8525 21039-21049 GO_EXT:macromolecule_denaturation denotes denaturing
T8526 21050-21064 CHEBI_EXT:polyacrylamide denotes polyacrylamide
T8527 21149-21162 GO:0005675 denotes TFIIH complex
T8528 21191-21193 SO_EXT:wild_type_entity_or_quality denotes wt
T8529 21239-21242 PR_EXT:000007164 denotes Xpd
T8530 21271-21276 GO:0005675 denotes TFIIH
T8531 21291-21294 PR_EXT:000007164 denotes Xpd
T8532 21314-21317 PR_EXT:000007164 denotes Xpd
T8533 21351-21354 PR_EXT:000007164 denotes Xpd
T8534 21368-21371 PR_EXT:000007164 denotes Xpd
T8535 21379-21384 CL_GO_EXT:cell denotes cells
T8536 21426-21446 PR_EXT:000008317 denotes p62 subunit of TFIIH
T8537 21441-21446 GO:0005675 denotes TFIIH
T8538 21532-21536 CL_GO_EXT:cell denotes cell
T8539 21543-21551 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T8540 21568-21570 SO_EXT:wild_type_entity_or_quality denotes wt
T8541 21571-21576 CL_GO_EXT:cell denotes cells
T8542 21581-21589 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T8543 21607-21610 PR_EXT:000007164 denotes Xpd
T8544 21618-21623 CL_GO_EXT:cell denotes cells
T8545 21652-21655 PR_EXT:000007164 denotes Xpd
T8546 21662-21667 CL_GO_EXT:cell denotes cells
T8547 21692-21694 SO_EXT:wild_type_entity_or_quality denotes wt
T8548 21695-21700 CL_GO_EXT:cell denotes cells
T8549 21705-21713 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T8550 21737-21740 PR_EXT:000007164 denotes Xpd
T8551 21750-21755 CL_GO_EXT:cell denotes cells
T8552 21785-21787 SO_EXT:wild_type_entity_or_quality denotes wt
T8553 21788-21793 CL_GO_EXT:cell denotes cells
T8554 21798-21806 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelled
T8555 21830-21833 PR_EXT:000007164 denotes Xpd
T8556 21841-21846 CL_GO_EXT:cell denotes cells
T8557 21930-21936 GO:0005634 denotes nuclei
T8558 21941-21945 CL_GO_EXT:cell denotes cell
T8559 21975-21983 SO_EXT:genotype_or_entity_with_genotype denotes genotype
T8560 22003-22008 CL_GO_EXT:cell denotes cells
T8561 22080-22082 SO_EXT:wild_type_entity_or_quality denotes wt
T8562 22157-22159 SO_EXT:wild_type_entity_or_quality denotes wt
T8563 22178-22182 CL_GO_EXT:cell denotes cell
T9207 9755-9758 PR_EXT:000007164 denotes Xpd
T9208 9767-9770 PR_EXT:000007164 denotes Xpd
T9209 9809-9812 PR_EXT:000007164 denotes Xpd
T9210 9822-9829 UBERON:0000922 denotes Embryos
T9237 16166-16169 PR_EXT:000007164 denotes Xpd
T9238 16172-16179 SO_EXT:0001023 denotes allelic
T9239 16191-16195 NCBITaxon:10088 denotes Mice
T9240 16200-16205 CL_GO_EXT:cell denotes Cells
T9264 31591-31599 SO_EXT:genotype_or_entity_with_genotype denotes Genotype
T9265 31627-31630 PR_EXT:000007164 denotes XPD
T9266 31670-31677 SO_EXT:0001023 denotes allelic
T9267 31738-31744 SO_EXT:0001023 denotes allele
T9268 31777-31783 SO_EXT:0001023 denotes allele
T9269 31826-31830 SO_EXT:null_sequence_entity denotes null
T9270 31891-31894 PR_EXT:000007164 denotes XPD
T9271 31895-31903 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T9272 31947-31954 SO_EXT:0001023 denotes allelic
T9273 32007-32014 SO_EXT:0001023 denotes alleles
T9274 32119-32123 SO_EXT:sequence_nullness denotes null
T9275 32124-32130 SO_EXT:0001023 denotes allele
T9276 32277-32283 SO_EXT:0001023 denotes allele
T9277 32317-32324 CHEBI_PR_EXT:protein denotes protein
T9278 32338-32346 GO_EXT:0004386 denotes helicase
T9279 32347-32354 SO_EXT:0000417 denotes domains
T6334 34018-34024 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T6335 34025-34029 NCBITaxon:10088 denotes mice
T6336 34045-34048 PR_EXT:000007164 denotes Xpd
T6337 34053-34056 PR_EXT:000007164 denotes XPD
T6338 34067-34070 PR_EXT:000007164 denotes Xpd
T6339 34077-34081 NCBITaxon:10088 denotes mice
T6340 34175-34185 SO_EXT:engineered_biological_sequence denotes constructs
T6341 34190-34193 PR_EXT:000007164 denotes Xpd
T6572 35088-35093 GO:0005675 denotes TFIIH
T6573 35094-35102 MOP:0000780 denotes incision
T6574 35103-35111 SO_EXT:sequence_deletion_process denotes excision
T6575 35286-35288 SO_EXT:wild_type_entity_or_quality denotes wt
T6576 35296-35299 PR_EXT:000007164 denotes Xpd
T6577 35312-35315 PR_EXT:000007164 denotes Xpd
T6578 35333-35336 PR_EXT:000007164 denotes Xpd
T6579 35343-35347 CL_GO_EXT:cell denotes cell
T6580 35418-35421 PR_EXT:000007164 denotes Xpd
T6581 35429-35434 CL_GO_EXT:cell denotes cells
T6582 35591-35595 CL_GO_EXT:cell denotes cell
T6583 35624-35632 MOP:0000780 denotes incision
T6584 35633-35641 SO_EXT:sequence_deletion_process denotes excision
T6585 35658-35669 GO_SO_EXT:sequence_rearrangement_process denotes recombinant
T6586 35670-35675 GO:0005675 denotes TFIIH
T6757 35775-35784 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labelling
T2539 14552-14556 UBERON_EXT:body denotes body
T2540 14670-14677 SO_EXT:sequence_rescue_process denotes rescued
T2541 14703-14706 PR_EXT:000007164 denotes Xpd
T2542 14716-14720 NCBITaxon:10088 denotes mice
T2543 14754-14763 UBERON:0000104 denotes life span
T2544 14815-14818 PR_EXT:000007164 denotes Xpd
T2545 14826-14830 NCBITaxon:10088 denotes mice
T2546 16242-16248 GO_EXT:fatality_or_lethality denotes lethal
T2547 16249-16252 PR_EXT:000007164 denotes Xpd
T2548 16258-16264 SO_EXT:0001023 denotes allele
T2549 16334-16337 PR_EXT:000007164 denotes Xpd
T2550 16341-16347 SO_EXT:0001023 denotes allele
T2551 16384-16387 PR_EXT:000007164 denotes Xpd
T2552 16395-16399 NCBITaxon:10088 denotes mice
T2553 16443-16450 NCBITaxon:33208 denotes animals
T2554 16467-16470 PR_EXT:000007164 denotes Xpd
T2555 16477-16483 SO_EXT:0001023 denotes allele
T2556 16500-16506 GO_EXT:fatality_or_lethality denotes lethal
T2557 16507-16510 PR_EXT:000007164 denotes Xpd
T2558 16515-16521 SO_EXT:0001023 denotes allele
T2559 16522-16529 SO_EXT:sequence_rescue_process denotes rescued
T2560 16530-16539 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T2561 16559-16563 UBERON:0001037 denotes hair
T2562 16636-16644 CHEBI_SO_EXT:cysteine denotes cysteine
T2563 16654-16662 CHEBI_SO_EXT:cysteine denotes cysteine
T2564 16706-16708 SO_EXT:wild_type_entity_or_quality denotes wt
T2565 16733-16739 GO:0007568 denotes ageing
T2566 16771-16776 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T1913 11280-11283 PR_EXT:000007164 denotes Xpd
T1914 11293-11297 NCBITaxon:10088 denotes mice
T1915 11313-11317 UBERON:0001037 denotes hair
T1916 11345-11349 UBERON:0001037 denotes hair
T1917 11345-11355 GO:0042633 denotes hair cycle
T1918 11380-11384 UBERON:0001137 denotes back
T1919 11407-11415 CHEBI:10545 denotes electron
T1920 11439-11442 PR_EXT:000007164 denotes Xpd
T1921 11452-11456 UBERON:0001037 denotes hair
T1922 11533-11538 UBERON:0001037 denotes hairs
T1923 11592-11602 CHEBI_SO_EXT:amino_acid denotes Amino acid
T1924 11627-11635 CHEBI_SO_EXT:cysteine denotes cysteine
T1925 11650-11654 UBERON:0001037 denotes hair
T1926 11662-11665 PR_EXT:000007164 denotes Xpd
T1927 11675-11679 NCBITaxon:10088 denotes mice
T1928 11714-11717 PR_EXT:000007164 denotes Xpd
T1929 11725-11732 NCBITaxon:33208 denotes animals
T1930 11757-11759 SO_EXT:wild_type_entity_or_quality denotes wt
T1931 11796-11799 PR_EXT:000007164 denotes Xpd
T1932 11849-11858 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneous
T1933 11905-11908 PR_EXT:000007164 denotes Xpd
T1934 11916-11920 NCBITaxon:10088 denotes mice
T1935 13216-13225 UBERON:0007376 denotes epidermis
T1936 13267-13275 _FRAGMENT denotes layer of
T1937 13290-13295 UBERON:0000119 denotes cells
T1938 13280-13289 GO:0005634 denotes nucleated
T1939 13280-13295 CL:0002242 denotes nucleated cells
T1940 13290-13295 CL_GO_EXT:cell denotes cells
T1941 13342-13351 GO:0070268 denotes cornified
T1942 13342-13357 UBERON:0002027 denotes cornified layer
T1943 13394-13409 UBERON:0001821 denotes sebacious gland
T1944 13456-13460 UBERON:0001037 denotes hair
T1945 13482-13486 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T1946 13490-13493 PR_EXT:000007164 denotes Xpd
T1947 13503-13507 NCBITaxon:10088 denotes mice
T1948 13560-13564 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T1949 13673-13676 PR_EXT:000007164 denotes Xpd
T1950 13684-13688 NCBITaxon:10088 denotes mice
T1951 13714-13721 SO_EXT:sequence_rescue_process denotes rescued
T1952 13747-13750 PR_EXT:000007164 denotes Xpd
T3225 18973-18979 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3226 18980-18985 GO:0005675 denotes TFIIH
T3227 19009-19020 SO_EXT:sequence_alteration_entity_or_process denotes alterations
T3228 19042-19045 PR_EXT:000007164 denotes XPD
T3229 19059-19062 PR_EXT:000007164 denotes XPD
T3230 19077-19080 PR_EXT:000007164 denotes XPD
T3231 19123-19126 GO:0006289 denotes NER
T3232 19165-19171 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3233 19172-19187 GO:0005675 denotes TFIIH complexes
T3234 19253-19260 SO_EXT:0001023 denotes allelic
T3235 19298-19303 CL_GO_EXT:cell denotes cells
T3236 19366-19372 GO:0006281 denotes repair
T3237 19421-19427 NCBITaxon:33208 denotes animal
T3238 22273-22274 GO:0006283 denotes t
T3239 22277-22278 PR_EXT:000007164 denotes X
T3240 22278-22279 PR_EXT:000008317 denotes p
T3241 22279-22280 PR_EXT:000005265 denotes d
T3242 22290-22293 PR_EXT:000007164 denotes Xpd
T3243 22306-22307 PR_EXT:000007164 denotes d
T3244 22307-22309 CL_GO_EXT:cell denotes es
T3245 22309-22310 PR_EXT:000007164 denotes p
T3246 22314-22315 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes d
T3247 22316-22317 CL_GO_EXT:cell denotes c
T3248 22321-22322 GO:0005634 denotes e
T3249 22325-22328 CHEBI_SO_EXT:mRNA denotes RNA
T3250 22384-22389 GO:0005675 denotes TFIIH
T3251 22422-22425 PR_EXT:000007164 denotes Xpd
T3252 22440-22443 PR_EXT:000007164 denotes Xpd
T3253 22452-22457 CL_GO_EXT:cell denotes cells
T3254 22562-22567 GO:0005675 denotes TFIIH
T3255 22586-22597 CL:0000057 denotes fibroblasts
T3256 22635-22637 SO_EXT:wild_type_entity_or_quality denotes wt
T3257 22693-22703 GO:0010467 denotes expression
T3258 22707-22711 CHEBI_SO_EXT:mRNA denotes mRNA
T3259 22721-22724 PR_EXT:000007164 denotes Xpd
T3260 22728-22734 SO_EXT:0001023 denotes allele
T3261 22751-22753 SO_EXT:wild_type_entity_or_quality denotes wt
T3262 22754-22760 SO_EXT:0001023 denotes allele
T3263 22774-22779 GO:0005675 denotes TFIIH
T3264 22780-22787 CHEBI_PR_EXT:protein denotes protein
T3265 22826-22831 NCBITaxon:10088 denotes mouse
T3266 22832-22835 PR_EXT:000007164 denotes Xpd
T3304 23999-24005 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T3305 24006-24013 SO_EXT:0001023 denotes alleles
T3306 24068-24072 UBERON:0001037 denotes hair
T3307 24127-24130 PR_EXT:000007164 denotes Xpd
T3308 24131-24138 SO_EXT:0001023 denotes alleles
T3309 24180-24185 GO:0005675 denotes TFIIH
T3310 24198-24202 NCBITaxon:10088 denotes mice
T3311 24207-24212 CL_GO_EXT:cell denotes cells
R245 T505 T504 _lexicallyChainedTo factor,transcription
R1225 T1937 T1936 _lexicallyChainedTo cells,layer of
R3174 T4710 T4709 _lexicallyChainedTo cells,differentiation of
R3175 T4713 T4712 _lexicallyChainedTo cells,enucleating
R3176 T4751 T4750 _lexicallyChainedTo cells,differentiation of
R3177 T4755 T4754 _lexicallyChainedTo cells,hair-shaft
R3178 T4783 T4782 _lexicallyChainedTo cells,ontogenesis of
R3179 T4787 T4786 _lexicallyChainedTo cells,hair-shaft
R3564 T5293 T5292 _lexicallyChainedTo DNA damage,transcription-coupled repair of
R4648 T6759 T6758 _lexicallyChainedTo TFIIH,p62 subunit of

2_test

Id Subject Object Predicate Lexical cue
17020410-8023851-84795120 2410-2411 8023851 denotes 2
17020410-6589607-84795121 2439-2440 6589607 denotes 3
17020410-8692963-84795122 2486-2487 8692963 denotes 4
17020410-7909321-84795123 2520-2521 7909321 denotes 5
17020410-15220921-84795124 3479-3480 15220921 denotes 6
17020410-8465201-84795125 3481-3482 8465201 denotes 7
17020410-11709541-84795126 3708-3709 11709541 denotes 8
17020410-11443545-84795126 3708-3709 11443545 denotes 8
17020410-11185579-84795127 3912-3914 11185579 denotes 11
17020410-1308368-84795128 4144-4146 1308368 denotes 12
17020410-11369901-84795128 4144-4146 11369901 denotes 12
17020410-10892338-84795128 4144-4146 10892338 denotes 12
17020410-11950998-84795128 4144-4146 11950998 denotes 12
17020410-11369901-84795129 4259-4261 11369901 denotes 13
17020410-11242112-84795130 4332-4334 11242112 denotes 16
17020410-12393803-84795131 4335-4337 12393803 denotes 17
17020410-15226750-84795132 4501-4503 15226750 denotes 18
17020410-9238033-84795133 4779-4781 9238033 denotes 19
17020410-10447254-84795134 4782-4784 10447254 denotes 20
17020410-9238033-84795135 5002-5004 9238033 denotes 19
17020410-11709541-84795136 5303-5304 11709541 denotes 8
17020410-11950998-84795137 5517-5519 11950998 denotes 15
17020410-9651581-84795138 5520-5522 9651581 denotes 21
17020410-9426063-84795139 7025-7027 9426063 denotes 22
17020410-16904611-84795140 7531-7533 16904611 denotes 23
17020410-9651581-84795141 11253-11255 9651581 denotes 21
17020410-9651581-84795142 11922-11924 9651581 denotes 21
17020410-11734544-84795143 13662-13664 11734544 denotes 24
17020410-11950998-84795144 13690-13692 11950998 denotes 15
17020410-1308368-84795145 13994-13996 1308368 denotes 12
17020410-11369901-84795146 13997-13999 11369901 denotes 13
17020410-11950998-84795147 14000-14002 11950998 denotes 15
17020410-16904611-84795148 14003-14005 16904611 denotes 23
17020410-11950998-84795149 14229-14231 11950998 denotes 15
17020410-9238033-84795150 18514-18516 9238033 denotes 19
17020410-7825573-84795151 18517-18519 7825573 denotes 25
17020410-16904611-84795152 18628-18630 16904611 denotes 23
17020410-11242112-84795153 22673-22675 11242112 denotes 16
17020410-12393803-84795154 22676-22678 12393803 denotes 17
17020410-11242112-84795155 27285-27287 11242112 denotes 16
17020410-11734544-84795156 27288-27290 11734544 denotes 24
17020410-8253091-84795157 29019-29021 8253091 denotes 26
17020410-12820975-84795158 29205-29207 12820975 denotes 27
17020410-12820975-84795159 29734-29736 12820975 denotes 27
17020410-9238033-84795160 29884-29886 9238033 denotes 19
17020410-11709541-84795161 30869-30870 11709541 denotes 8
17020410-11709541-84795162 31318-31319 11709541 denotes 8
17020410-9285782-84795163 32787-32789 9285782 denotes 28
17020410-12940920-84795164 33160-33162 12940920 denotes 29
17020410-9651581-84795165 34113-34115 9651581 denotes 21
17020410-9426063-84795166 34116-34118 9426063 denotes 22
17020410-9651581-84795167 34536-34538 9651581 denotes 21
17020410-11950998-84795168 34728-34730 11950998 denotes 15
17020410-9651581-84795169 35201-35203 9651581 denotes 21
17020410-12531012-84795170 35204-35206 12531012 denotes 30
17020410-9651581-84795171 35493-35495 9651581 denotes 21
17020410-12820975-84795172 35726-35728 12820975 denotes 27
17020410-11242112-84795173 35900-35902 11242112 denotes 16
17020410-12393803-84795174 35903-35905 12393803 denotes 17
T80536 2410-2411 8023851 denotes 2
T45327 2439-2440 6589607 denotes 3
T57048 2486-2487 8692963 denotes 4
T8272 2520-2521 7909321 denotes 5
T92258 3479-3480 15220921 denotes 6
T31924 3481-3482 8465201 denotes 7
T49919 3708-3709 11709541 denotes 8
T59412 3708-3709 11443545 denotes 8
T88110 3912-3914 11185579 denotes 11
T43502 4144-4146 1308368 denotes 12
T79694 4144-4146 11369901 denotes 12
T70430 4144-4146 10892338 denotes 12
T83742 4144-4146 11950998 denotes 12
T54985 4259-4261 11369901 denotes 13
T87059 4332-4334 11242112 denotes 16
T94780 4335-4337 12393803 denotes 17
T90963 4501-4503 15226750 denotes 18
T56327 4779-4781 9238033 denotes 19
T63905 4782-4784 10447254 denotes 20
T81319 5002-5004 9238033 denotes 19
T90035 5303-5304 11709541 denotes 8
T24869 5517-5519 11950998 denotes 15
T77326 5520-5522 9651581 denotes 21
T67903 7025-7027 9426063 denotes 22
T71501 7531-7533 16904611 denotes 23
T21650 11253-11255 9651581 denotes 21
T11080 11922-11924 9651581 denotes 21
T41145 13662-13664 11734544 denotes 24
T48844 13690-13692 11950998 denotes 15
T26954 13994-13996 1308368 denotes 12
T75835 13997-13999 11369901 denotes 13
T66273 14000-14002 11950998 denotes 15
T85538 14003-14005 16904611 denotes 23
T96771 14229-14231 11950998 denotes 15
T77924 18514-18516 9238033 denotes 19
T64659 18517-18519 7825573 denotes 25
T30893 18628-18630 16904611 denotes 23
T9600 22673-22675 11242112 denotes 16
T46580 22676-22678 12393803 denotes 17
T86483 27285-27287 11242112 denotes 16
T92993 27288-27290 11734544 denotes 24
T41376 29019-29021 8253091 denotes 26
T97368 29205-29207 12820975 denotes 27
T95008 29734-29736 12820975 denotes 27
T14991 29884-29886 9238033 denotes 19
T71740 30869-30870 11709541 denotes 8
T95120 31318-31319 11709541 denotes 8
T66252 32787-32789 9285782 denotes 28
T609 33160-33162 12940920 denotes 29
T86762 34113-34115 9651581 denotes 21
T68945 34116-34118 9426063 denotes 22
T30574 34536-34538 9651581 denotes 21
T65613 34728-34730 11950998 denotes 15
T19802 35201-35203 9651581 denotes 21
T38157 35204-35206 12531012 denotes 30
T62073 35493-35495 9651581 denotes 21
T15235 35726-35728 12820975 denotes 27
T99220 35900-35902 11242112 denotes 16
T28976 35903-35905 12393803 denotes 17