PMC:1570465 / 1953-2880
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1570465","sourcedb":"PMC","sourceid":"1570465","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1570465","text":"The biological problems addressed by motif finding are complex and varied, and no single currently existing method can solve them completely (e.g., see [1,2]). For DNA sequences, motif finding is often applied to sets of sequences from a single genome that have been identified as possessing a common motif, either through DNA microarray studies [3], ChIP-chip experiments [4] or protein binding microarrays [5]. An orthogonal approach, which attempts to identify regulatory sites among a set of orthologous genes across genomes of varying phylogenetic distance, is adopted by [6-10]. For protein sequences, and especially in the case of divergent sequence motifs, it is particularly useful to incorporate amino acid substitution matrices [11,12]. Often, motif finding methods are either tailor-made to a specific variant of the motif finding problem, or perform very differently when presented with a diverse set of instances.","tracks":[{"project":"2_test","denotations":[{"id":"16916460-15637633-1687050","span":{"begin":153,"end":154},"obj":"15637633"},{"id":"16916460-16284194-1687051","span":{"begin":155,"end":156},"obj":"16284194"},{"id":"16916460-10391217-1687052","span":{"begin":347,"end":348},"obj":"10391217"},{"id":"16916460-12399584-1687053","span":{"begin":374,"end":375},"obj":"12399584"},{"id":"16916460-15543148-1687054","span":{"begin":409,"end":410},"obj":"15543148"},{"id":"16916460-10854408-1687055","span":{"begin":578,"end":579},"obj":"10854408"},{"id":"16916460-12775844-1687055","span":{"begin":578,"end":579},"obj":"12775844"},{"id":"16916460-11160901-1687055","span":{"begin":578,"end":579},"obj":"11160901"},{"id":"16916460-11997340-1687055","span":{"begin":578,"end":579},"obj":"11997340"},{"id":"16916460-12748633-1687055","span":{"begin":578,"end":579},"obj":"12748633"},{"id":"16916460-1438297-1687056","span":{"begin":743,"end":745},"obj":"1438297"}],"attributes":[{"subj":"16916460-15637633-1687050","pred":"source","obj":"2_test"},{"subj":"16916460-16284194-1687051","pred":"source","obj":"2_test"},{"subj":"16916460-10391217-1687052","pred":"source","obj":"2_test"},{"subj":"16916460-12399584-1687053","pred":"source","obj":"2_test"},{"subj":"16916460-15543148-1687054","pred":"source","obj":"2_test"},{"subj":"16916460-10854408-1687055","pred":"source","obj":"2_test"},{"subj":"16916460-12775844-1687055","pred":"source","obj":"2_test"},{"subj":"16916460-11160901-1687055","pred":"source","obj":"2_test"},{"subj":"16916460-11997340-1687055","pred":"source","obj":"2_test"},{"subj":"16916460-12748633-1687055","pred":"source","obj":"2_test"},{"subj":"16916460-1438297-1687056","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93c4","default":true}]}]}}