PMC:1564426 / 56688-57366 JSONTXT

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T30401","span":{"begin":0,"end":6},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T30402","span":{"begin":7,"end":11},"obj":"NCBITaxon:10088"},{"id":"T30403","span":{"begin":55,"end":61},"obj":"GO_EXT:killing"},{"id":"T30404","span":{"begin":81,"end":84},"obj":"CHEBI:16526"},{"id":"T30405","span":{"begin":97,"end":101},"obj":"NCBITaxon:10088"},{"id":"T30406","span":{"begin":129,"end":133},"obj":"UBERON_EXT:zone_of_skin_or_skin_of_body"},{"id":"T30407","span":{"begin":168,"end":176},"obj":"CHEBI_EXT:nitrogen"},{"id":"T30408","span":{"begin":214,"end":221},"obj":"CHEBI_EXT:33893"},{"id":"T30409","span":{"begin":249,"end":258},"obj":"CHEBI_EXT:polyatomic_entity_or_group"},{"id":"T30410","span":{"begin":320,"end":328},"obj":"CHEBI:75958"},{"id":"T30411","span":{"begin":388,"end":392},"obj":"NCBITaxon:10088"},{"id":"T30412","span":{"begin":444,"end":451},"obj":"UBERON:0000479"},{"id":"T30413","span":{"begin":488,"end":497},"obj":"CHEBI_EXT:polyatomic_entity_or_group"},{"id":"T30414","span":{"begin":521,"end":531},"obj":"UBERON:0000468"},{"id":"T30415","span":{"begin":553,"end":561},"obj":"CHEBI:75958"},{"id":"T30416","span":{"begin":598,"end":604},"obj":"NCBITaxon:9989"}],"text":"Mutant mice and age-matching littermates were humanely killed at various ages by CO2 inhalation. Mice were skinned and pieces of skin were either snap-frozen in liquid nitrogen or immediately homogenized in Trizol reagent and stored at −80 °C until molecular analysis, or fixed flat on a piece of paper towel in Bouin's solution for histological and immunohistochemical examinations. The mice were then dissected for gross examination, various tissues were similarly collected for future molecular analyses, and then the whole body was fixed in Bouin's solution. The samples were then submitted to Rodent Histopathological Core for processing and histopathological examinations."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T30363","span":{"begin":7,"end":11},"obj":"NCBITaxon:10088"},{"id":"T30364","span":{"begin":81,"end":84},"obj":"CHEBI:16526"},{"id":"T30365","span":{"begin":97,"end":101},"obj":"NCBITaxon:10088"},{"id":"T30366","span":{"begin":214,"end":221},"obj":"CHEBI:33893"},{"id":"T30367","span":{"begin":320,"end":328},"obj":"CHEBI:75958"},{"id":"T30368","span":{"begin":388,"end":392},"obj":"NCBITaxon:10088"},{"id":"T30369","span":{"begin":444,"end":451},"obj":"UBERON:0000479"},{"id":"T30370","span":{"begin":521,"end":531},"obj":"UBERON:0000468"},{"id":"T30371","span":{"begin":553,"end":561},"obj":"CHEBI:75958"},{"id":"T30372","span":{"begin":598,"end":604},"obj":"NCBITaxon:9989"}],"text":"Mutant mice and age-matching littermates were humanely killed at various ages by CO2 inhalation. Mice were skinned and pieces of skin were either snap-frozen in liquid nitrogen or immediately homogenized in Trizol reagent and stored at −80 °C until molecular analysis, or fixed flat on a piece of paper towel in Bouin's solution for histological and immunohistochemical examinations. The mice were then dissected for gross examination, various tissues were similarly collected for future molecular analyses, and then the whole body was fixed in Bouin's solution. The samples were then submitted to Rodent Histopathological Core for processing and histopathological examinations."}

{"project":"craft-sa-dev","denotations":[{"id":"T30455","span":{"begin":0,"end":6},"obj":"JJ"},{"id":"T30456","span":{"begin":7,"end":11},"obj":"NNS"},{"id":"T30457","span":{"begin":55,"end":61},"obj":"VBN"},{"id":"T30458","span":{"begin":12,"end":15},"obj":"CC"},{"id":"T30459","span":{"begin":16,"end":19},"obj":"NN"},{"id":"T30460","span":{"begin":20,"end":28},"obj":"JJ"},{"id":"T30461","span":{"begin":19,"end":20},"obj":"HYPH"},{"id":"T30462","span":{"begin":29,"end":40},"obj":"NNS"},{"id":"T30463","span":{"begin":41,"end":45},"obj":"VBD"},{"id":"T30464","span":{"begin":46,"end":54},"obj":"RB"},{"id":"T30465","span":{"begin":62,"end":64},"obj":"IN"},{"id":"T30466","span":{"begin":65,"end":72},"obj":"JJ"},{"id":"T30467","span":{"begin":73,"end":77},"obj":"NNS"},{"id":"T30468","span":{"begin":78,"end":80},"obj":"IN"},{"id":"T30469","span":{"begin":81,"end":84},"obj":"NN"},{"id":"T30470","span":{"begin":85,"end":95},"obj":"NN"},{"id":"T30471","span":{"begin":95,"end":96},"obj":"."},{"id":"T30472","span":{"begin":96,"end":383},"obj":"sentence"},{"id":"T30473","span":{"begin":97,"end":101},"obj":"NNS"},{"id":"T30474","span":{"begin":107,"end":114},"obj":"VBN"},{"id":"T30475","span":{"begin":102,"end":106},"obj":"VBD"},{"id":"T30476","span":{"begin":115,"end":118},"obj":"CC"},{"id":"T30477","span":{"begin":119,"end":125},"obj":"NNS"},{"id":"T30478","span":{"begin":151,"end":157},"obj":"VBN"},{"id":"T30479","span":{"begin":126,"end":128},"obj":"IN"},{"id":"T30480","span":{"begin":129,"end":133},"obj":"NN"},{"id":"T30481","span":{"begin":134,"end":138},"obj":"VBD"},{"id":"T30482","span":{"begin":139,"end":145},"obj":"CC"},{"id":"T30483","span":{"begin":146,"end":150},"obj":"NN"},{"id":"T30484","span":{"begin":150,"end":151},"obj":"HYPH"},{"id":"T30485","span":{"begin":158,"end":160},"obj":"IN"},{"id":"T30486","span":{"begin":161,"end":167},"obj":"JJ"},{"id":"T30487","span":{"begin":168,"end":176},"obj":"NN"},{"id":"T30488","span":{"begin":177,"end":179},"obj":"CC"},{"id":"T30489","span":{"begin":180,"end":191},"obj":"RB"},{"id":"T30490","span":{"begin":192,"end":203},"obj":"VBN"},{"id":"T30491","span":{"begin":204,"end":206},"obj":"IN"},{"id":"T30492","span":{"begin":207,"end":213},"obj":"NNP"},{"id":"T30493","span":{"begin":214,"end":221},"obj":"NN"},{"id":"T30494","span":{"begin":222,"end":225},"obj":"CC"},{"id":"T30495","span":{"begin":226,"end":232},"obj":"VBN"},{"id":"T30496","span":{"begin":233,"end":235},"obj":"IN"},{"id":"T30497","span":{"begin":236,"end":237},"obj":"SYM"},{"id":"T30498","span":{"begin":237,"end":239},"obj":"CD"},{"id":"T30499","span":{"begin":240,"end":242},"obj":"NNS"},{"id":"T30500","span":{"begin":243,"end":248},"obj":"IN"},{"id":"T30501","span":{"begin":249,"end":258},"obj":"JJ"},{"id":"T30502","span":{"begin":259,"end":267},"obj":"NN"},{"id":"T30503","span":{"begin":267,"end":269},"obj":","},{"id":"T30504","span":{"begin":269,"end":271},"obj":"CC"},{"id":"T30505","span":{"begin":272,"end":277},"obj":"VBN"},{"id":"T30506","span":{"begin":278,"end":282},"obj":"JJ"},{"id":"T30507","span":{"begin":283,"end":285},"obj":"IN"},{"id":"T30508","span":{"begin":286,"end":287},"obj":"DT"},{"id":"T30509","span":{"begin":288,"end":293},"obj":"NN"},{"id":"T30510","span":{"begin":294,"end":296},"obj":"IN"},{"id":"T30511","span":{"begin":297,"end":302},"obj":"NN"},{"id":"T30512","span":{"begin":303,"end":308},"obj":"NN"},{"id":"T30513","span":{"begin":309,"end":311},"obj":"IN"},{"id":"T30514","span":{"begin":312,"end":317},"obj":"NNP"},{"id":"T30515","span":{"begin":320,"end":328},"obj":"NN"},{"id":"T30516","span":{"begin":317,"end":319},"obj":"POS"},{"id":"T30517","span":{"begin":329,"end":332},"obj":"IN"},{"id":"T30518","span":{"begin":333,"end":345},"obj":"JJ"},{"id":"T30519","span":{"begin":370,"end":382},"obj":"NNS"},{"id":"T30520","span":{"begin":346,"end":349},"obj":"CC"},{"id":"T30521","span":{"begin":350,"end":369},"obj":"JJ"},{"id":"T30522","span":{"begin":382,"end":383},"obj":"."},{"id":"T30523","span":{"begin":383,"end":562},"obj":"sentence"},{"id":"T30524","span":{"begin":384,"end":387},"obj":"DT"},{"id":"T30525","span":{"begin":388,"end":392},"obj":"NNS"},{"id":"T30526","span":{"begin":403,"end":412},"obj":"VBN"},{"id":"T30527","span":{"begin":393,"end":397},"obj":"VBD"},{"id":"T30528","span":{"begin":398,"end":402},"obj":"RB"},{"id":"T30529","span":{"begin":413,"end":416},"obj":"IN"},{"id":"T30530","span":{"begin":417,"end":422},"obj":"JJ"},{"id":"T30531","span":{"begin":423,"end":434},"obj":"NN"},{"id":"T30532","span":{"begin":434,"end":436},"obj":","},{"id":"T30533","span":{"begin":436,"end":443},"obj":"JJ"},{"id":"T30534","span":{"begin":444,"end":451},"obj":"NNS"},{"id":"T30535","span":{"begin":467,"end":476},"obj":"VBN"},{"id":"T30536","span":{"begin":452,"end":456},"obj":"VBD"},{"id":"T30537","span":{"begin":457,"end":466},"obj":"RB"},{"id":"T30538","span":{"begin":477,"end":480},"obj":"IN"},{"id":"T30539","span":{"begin":481,"end":487},"obj":"JJ"},{"id":"T30540","span":{"begin":498,"end":506},"obj":"NNS"},{"id":"T30541","span":{"begin":488,"end":497},"obj":"JJ"},{"id":"T30542","span":{"begin":506,"end":508},"obj":","},{"id":"T30543","span":{"begin":508,"end":511},"obj":"CC"},{"id":"T30544","span":{"begin":512,"end":516},"obj":"RB"},{"id":"T30545","span":{"begin":536,"end":541},"obj":"VBN"},{"id":"T30546","span":{"begin":517,"end":520},"obj":"DT"},{"id":"T30547","span":{"begin":527,"end":531},"obj":"NN"},{"id":"T30548","span":{"begin":521,"end":526},"obj":"JJ"},{"id":"T30549","span":{"begin":532,"end":535},"obj":"VBD"},{"id":"T30550","span":{"begin":542,"end":544},"obj":"IN"},{"id":"T30551","span":{"begin":545,"end":550},"obj":"NNP"},{"id":"T30552","span":{"begin":553,"end":561},"obj":"NN"},{"id":"T30553","span":{"begin":550,"end":552},"obj":"POS"},{"id":"T30554","span":{"begin":561,"end":562},"obj":"."},{"id":"T30555","span":{"begin":562,"end":678},"obj":"sentence"},{"id":"T30556","span":{"begin":563,"end":566},"obj":"DT"},{"id":"T30557","span":{"begin":567,"end":574},"obj":"NNS"},{"id":"T30558","span":{"begin":585,"end":594},"obj":"VBN"},{"id":"T30559","span":{"begin":575,"end":579},"obj":"VBD"},{"id":"T30560","span":{"begin":580,"end":584},"obj":"RB"},{"id":"T30561","span":{"begin":595,"end":597},"obj":"IN"},{"id":"T30562","span":{"begin":598,"end":604},"obj":"NNP"},{"id":"T30563","span":{"begin":623,"end":627},"obj":"NNP"},{"id":"T30564","span":{"begin":605,"end":622},"obj":"NNP"},{"id":"T30565","span":{"begin":628,"end":631},"obj":"IN"},{"id":"T30566","span":{"begin":632,"end":642},"obj":"NN"},{"id":"T30567","span":{"begin":643,"end":646},"obj":"CC"},{"id":"T30568","span":{"begin":647,"end":664},"obj":"JJ"},{"id":"T30569","span":{"begin":665,"end":677},"obj":"NNS"},{"id":"T30570","span":{"begin":677,"end":678},"obj":"."}],"relations":[{"id":"R9151","pred":"amod","subj":"T30455","obj":"T30456"},{"id":"R9152","pred":"nsubjpass","subj":"T30456","obj":"T30457"},{"id":"R9153","pred":"cc","subj":"T30458","obj":"T30456"},{"id":"R9154","pred":"npadvmod","subj":"T30459","obj":"T30460"},{"id":"R9155","pred":"amod","subj":"T30460","obj":"T30462"},{"id":"R9156","pred":"punct","subj":"T30461","obj":"T30460"},{"id":"R9157","pred":"conj","subj":"T30462","obj":"T30456"},{"id":"R9158","pred":"auxpass","subj":"T30463","obj":"T30457"},{"id":"R9159","pred":"advmod","subj":"T30464","obj":"T30457"},{"id":"R9160","pred":"prep","subj":"T30465","obj":"T30457"},{"id":"R9161","pred":"amod","subj":"T30466","obj":"T30467"},{"id":"R9162","pred":"pobj","subj":"T30467","obj":"T30465"},{"id":"R9163","pred":"prep","subj":"T30468","obj":"T30457"},{"id":"R9164","pred":"compound","subj":"T30469","obj":"T30470"},{"id":"R9165","pred":"pobj","subj":"T30470","obj":"T30468"},{"id":"R9166","pred":"punct","subj":"T30471","obj":"T30457"},{"id":"R9167","pred":"nsubjpass","subj":"T30473","obj":"T30474"},{"id":"R9168","pred":"auxpass","subj":"T30475","obj":"T30474"},{"id":"R9169","pred":"cc","subj":"T30476","obj":"T30474"},{"id":"R9170","pred":"nsubj","subj":"T30477","obj":"T30478"},{"id":"R9171","pred":"conj","subj":"T30478","obj":"T30474"},{"id":"R9172","pred":"prep","subj":"T30479","obj":"T30477"},{"id":"R9173","pred":"pobj","subj":"T30480","obj":"T30479"},{"id":"R9174","pred":"aux","subj":"T30481","obj":"T30478"},{"id":"R9175","pred":"preconj","subj":"T30482","obj":"T30478"},{"id":"R9176","pred":"dep","subj":"T30483","obj":"T30478"},{"id":"R9177","pred":"punct","subj":"T30484","obj":"T30478"},{"id":"R9178","pred":"prep","subj":"T30485","obj":"T30478"},{"id":"R9179","pred":"amod","subj":"T30486","obj":"T30487"},{"id":"R9180","pred":"pobj","subj":"T30487","obj":"T30485"},{"id":"R9181","pred":"cc","subj":"T30488","obj":"T30478"},{"id":"R9182","pred":"advmod","subj":"T30489","obj":"T30490"},{"id":"R9183","pred":"conj","subj":"T30490","obj":"T30478"},{"id":"R9184","pred":"prep","subj":"T30491","obj":"T30490"},{"id":"R9185","pred":"compound","subj":"T30492","obj":"T30493"},{"id":"R9186","pred":"pobj","subj":"T30493","obj":"T30491"},{"id":"R9187","pred":"cc","subj":"T30494","obj":"T30478"},{"id":"R9188","pred":"conj","subj":"T30495","obj":"T30478"},{"id":"R9189","pred":"prep","subj":"T30496","obj":"T30495"},{"id":"R9190","pred":"punct","subj":"T30497","obj":"T30498"},{"id":"R9191","pred":"nummod","subj":"T30498","obj":"T30499"},{"id":"R9192","pred":"pobj","subj":"T30499","obj":"T30496"},{"id":"R9193","pred":"prep","subj":"T30500","obj":"T30495"},{"id":"R9194","pred":"amod","subj":"T30501","obj":"T30502"},{"id":"R9195","pred":"pobj","subj":"T30502","obj":"T30500"},{"id":"R9196","pred":"punct","subj":"T30503","obj":"T30495"},{"id":"R9197","pred":"cc","subj":"T30504","obj":"T30495"},{"id":"R9198","pred":"conj","subj":"T30505","obj":"T30495"},{"id":"R9199","pred":"oprd","subj":"T30506","obj":"T30505"},{"id":"R9200","pred":"prep","subj":"T30507","obj":"T30505"},{"id":"R9201","pred":"det","subj":"T30508","obj":"T30509"},{"id":"R9202","pred":"pobj","subj":"T30509","obj":"T30507"},{"id":"R9203","pred":"prep","subj":"T30510","obj":"T30509"},{"id":"R9204","pred":"compound","subj":"T30511","obj":"T30512"},{"id":"R9205","pred":"pobj","subj":"T30512","obj":"T30510"},{"id":"R9206","pred":"prep","subj":"T30513","obj":"T30505"},{"id":"R9207","pred":"poss","subj":"T30514","obj":"T30515"},{"id":"R9208","pred":"pobj","subj":"T30515","obj":"T30513"},{"id":"R9209","pred":"case","subj":"T30516","obj":"T30514"},{"id":"R9210","pred":"prep","subj":"T30517","obj":"T30505"},{"id":"R9211","pred":"amod","subj":"T30518","obj":"T30519"},{"id":"R9212","pred":"pobj","subj":"T30519","obj":"T30517"},{"id":"R9213","pred":"cc","subj":"T30520","obj":"T30518"},{"id":"R9214","pred":"conj","subj":"T30521","obj":"T30518"},{"id":"R9215","pred":"punct","subj":"T30522","obj":"T30478"},{"id":"R9216","pred":"det","subj":"T30524","obj":"T30525"},{"id":"R9217","pred":"nsubjpass","subj":"T30525","obj":"T30526"},{"id":"R9218","pred":"auxpass","subj":"T30527","obj":"T30526"},{"id":"R9219","pred":"advmod","subj":"T30528","obj":"T30526"},{"id":"R9220","pred":"prep","subj":"T30529","obj":"T30526"},{"id":"R9221","pred":"amod","subj":"T30530","obj":"T30531"},{"id":"R9222","pred":"pobj","subj":"T30531","obj":"T30529"},{"id":"R9223","pred":"punct","subj":"T30532","obj":"T30526"},{"id":"R9224","pred":"amod","subj":"T30533","obj":"T30534"},{"id":"R9225","pred":"nsubjpass","subj":"T30534","obj":"T30535"},{"id":"R9226","pred":"conj","subj":"T30535","obj":"T30526"},{"id":"R9227","pred":"auxpass","subj":"T30536","obj":"T30535"},{"id":"R9228","pred":"advmod","subj":"T30537","obj":"T30535"},{"id":"R9229","pred":"prep","subj":"T30538","obj":"T30535"},{"id":"R9230","pred":"amod","subj":"T30539","obj":"T30540"},{"id":"R9231","pred":"pobj","subj":"T30540","obj":"T30538"},{"id":"R9232","pred":"amod","subj":"T30541","obj":"T30540"},{"id":"R9233","pred":"punct","subj":"T30542","obj":"T30535"},{"id":"R9234","pred":"cc","subj":"T30543","obj":"T30535"},{"id":"R9235","pred":"advmod","subj":"T30544","obj":"T30545"},{"id":"R9236","pred":"conj","subj":"T30545","obj":"T30535"},{"id":"R9237","pred":"det","subj":"T30546","obj":"T30547"},{"id":"R9238","pred":"nsubjpass","subj":"T30547","obj":"T30545"},{"id":"R9239","pred":"amod","subj":"T30548","obj":"T30547"},{"id":"R9240","pred":"auxpass","subj":"T30549","obj":"T30545"},{"id":"R9241","pred":"prep","subj":"T30550","obj":"T30545"},{"id":"R9242","pred":"poss","subj":"T30551","obj":"T30552"},{"id":"R9243","pred":"pobj","subj":"T30552","obj":"T30550"},{"id":"R9244","pred":"case","subj":"T30553","obj":"T30551"},{"id":"R9245","pred":"punct","subj":"T30554","obj":"T30545"},{"id":"R9246","pred":"det","subj":"T30556","obj":"T30557"},{"id":"R9247","pred":"nsubjpass","subj":"T30557","obj":"T30558"},{"id":"R9248","pred":"auxpass","subj":"T30559","obj":"T30558"},{"id":"R9249","pred":"advmod","subj":"T30560","obj":"T30558"},{"id":"R9250","pred":"prep","subj":"T30561","obj":"T30558"},{"id":"R9251","pred":"compound","subj":"T30562","obj":"T30563"},{"id":"R9252","pred":"pobj","subj":"T30563","obj":"T30561"},{"id":"R9253","pred":"compound","subj":"T30564","obj":"T30563"},{"id":"R9254","pred":"prep","subj":"T30565","obj":"T30558"},{"id":"R9255","pred":"pobj","subj":"T30566","obj":"T30565"},{"id":"R9256","pred":"cc","subj":"T30567","obj":"T30566"},{"id":"R9257","pred":"amod","subj":"T30568","obj":"T30569"},{"id":"R9258","pred":"conj","subj":"T30569","obj":"T30566"},{"id":"R9259","pred":"punct","subj":"T30570","obj":"T30558"}],"text":"Mutant mice and age-matching littermates were humanely killed at various ages by CO2 inhalation. Mice were skinned and pieces of skin were either snap-frozen in liquid nitrogen or immediately homogenized in Trizol reagent and stored at −80 °C until molecular analysis, or fixed flat on a piece of paper towel in Bouin's solution for histological and immunohistochemical examinations. The mice were then dissected for gross examination, various tissues were similarly collected for future molecular analyses, and then the whole body was fixed in Bouin's solution. The samples were then submitted to Rodent Histopathological Core for processing and histopathological examinations."}