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PMC:1564426 / 4546-5733 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2278 21-24 PR_EXT:000004122 denotes APC
T2279 46-51 NCBITaxon:9606 denotes human
T2280 52-62 UBERON:0012652 denotes colorectal
T2281 109-115 UBERON:0000479 denotes tissue
T2282 193-220 GO:0030111 denotes regulation of Wnt signaling
T2283 224-233 UBERON:0000922 denotes embryonic
T2284 224-251 GO:0009880 denotes embryonic pattern formation
T2285 256-272 _FRAGMENT denotes morphogenesis of
T2286 278-284 GO:0009887 denotes organs
T2287 278-284 UBERON:0000062 denotes organs
T2288 315-318 PR_EXT:000004122 denotes APC
T2289 346-353 UBERON:0001155 denotes colonic
T2290 354-361 UBERON:0000479 denotes tissues
T2291 424-430 NCBITaxon:9606 denotes humans
T2292 471-474 PR_EXT:000004122 denotes Apc
T2293 504-508 NCBITaxon:10088 denotes mice
T2294 530-533 PR_EXT:000004122 denotes Apc
T2295 534-542 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2296 552-563 SO_EXT:0000704 denotes genetically
T2297 564-572 SO_EXT:sequence_alteration_process denotes modified
T2298 573-578 NCBITaxon:10088 denotes mouse
T2299 591-594 PR_EXT:000004122 denotes Apc
T2300 679-695 UBERON:0005409 denotes gastrointestinal
T2301 745-750 NCBITaxon:10088 denotes Mouse
T2302 751-758 UBERON:0000922 denotes embryos
T2303 787-794 SO_EXT:0000704 denotes genetic
T2304 795-807 SO_EXT:sequence_alteration_entity_or_process denotes modification
T2306 819-832 GO:0009790 denotes embryogenesis
T2307 879-891 GO:0007369 denotes gastrulation
T2308 948-951 PR_EXT:000004122 denotes Apc
T2309 986-993 UBERON:0000479 denotes tissues
T2310 1011-1016 NCBITaxon:10088 denotes mouse
T2311 1053-1061 SO_EXT:sequence_alteration_process denotes modified
T2312 1062-1068 SO_EXT:0001023 denotes allele
T2313 1073-1077 GO:0007618 denotes mate
T2314 1088-1093 NCBITaxon:10088 denotes mouse
T2315 1122-1134 SO_EXT:sequence_alteration_entity_or_process denotes modification
T2316 1154-1160 SO_EXT:0001023 denotes allele
T2317 1173-1177 CL_GO_EXT:cell denotes cell
T2305 808-811 GO:0016265 denotes die
R244 T2286 T2285 _lexicallyChainedTo organs,morphogenesis of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2128 21-24 PR:000004122 denotes APC
T2129 46-51 NCBITaxon:9606 denotes human
T2130 52-62 UBERON:0012652 denotes colorectal
T2131 109-115 UBERON:0000479 denotes tissue
T2132 193-220 GO:0030111 denotes regulation of Wnt signaling
T2133 224-233 UBERON:0000922 denotes embryonic
T2134 224-251 GO:0009880 denotes embryonic pattern formation
T2135 256-272 _FRAGMENT denotes morphogenesis of
T2136 278-284 GO:0009887 denotes organs
T2137 278-284 UBERON:0000062 denotes organs
T2138 315-318 PR:000004122 denotes APC
T2139 346-353 UBERON:0001155 denotes colonic
T2140 354-361 UBERON:0000479 denotes tissues
T2141 424-430 NCBITaxon:9606 denotes humans
T2142 471-474 PR:000004122 denotes Apc
T2143 504-508 NCBITaxon:10088 denotes mice
T2144 530-533 PR:000004122 denotes Apc
T2145 552-563 SO:0000704 denotes genetically
T2146 573-578 NCBITaxon:10088 denotes mouse
T2147 591-594 PR:000004122 denotes Apc
T2148 679-695 UBERON:0005409 denotes gastrointestinal
T2149 745-750 NCBITaxon:10088 denotes Mouse
T2150 751-758 UBERON:0000922 denotes embryos
T2151 787-794 SO:0000704 denotes genetic
T2152 808-811 GO:0016265 denotes die
T2153 819-832 GO:0009790 denotes embryogenesis
T2154 879-891 GO:0007369 denotes gastrulation
T2155 948-951 PR:000004122 denotes Apc
T2156 986-993 UBERON:0000479 denotes tissues
T2157 1011-1016 NCBITaxon:10088 denotes mouse
T2158 1062-1068 SO:0001023 denotes allele
T2159 1073-1077 GO:0007618 denotes mate
T2160 1088-1093 NCBITaxon:10088 denotes mouse
T2161 1154-1160 SO:0001023 denotes allele
R238 T2136 T2135 _lexicallyChainedTo organs,morphogenesis of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T2696 0-8 IN denotes Although
T2697 70-72 VBZ denotes is
T2698 9-12 DT denotes the
T2699 13-17 NN denotes role
T2700 18-20 IN denotes of
T2701 21-24 NN denotes APC
T2702 25-27 IN denotes in
T2703 28-31 DT denotes the
T2704 32-42 NN denotes initiation
T2705 43-45 IN denotes of
T2706 46-51 JJ denotes human
T2707 63-69 NN denotes cancer
T2708 52-62 JJ denotes colorectal
T2709 157-167 VBN denotes understood
T2710 73-77 RB denotes well
T2711 78-89 JJ denotes established
T2712 89-91 , denotes ,
T2713 91-94 PRP$ denotes its
T2714 95-99 NN denotes role
T2715 100-102 IN denotes in
T2716 103-108 JJ denotes other
T2717 134-143 NNS denotes processes
T2718 109-115 NN denotes tissue
T2719 116-119 CC denotes and
T2720 120-133 JJ denotes developmental
T2721 144-147 VBP denotes are
T2722 148-151 RB denotes not
T2723 152-156 RB denotes well
T2724 167-168 . denotes .
T2725 168-431 sentence denotes Given the importance of regulation of Wnt signaling in embryonic pattern formation and morphogenesis of many organs, mechanistic understanding of APC in development and in extracolonic tissues becomes critical to better assess potential adverse events in humans.
T2726 169-174 VBN denotes Given
T2727 362-369 VBZ denotes becomes
T2728 175-178 DT denotes the
T2729 179-189 NN denotes importance
T2730 190-192 IN denotes of
T2731 193-203 NN denotes regulation
T2732 204-206 IN denotes of
T2733 207-210 NN denotes Wnt
T2734 211-220 NN denotes signaling
T2735 221-223 IN denotes in
T2736 224-233 JJ denotes embryonic
T2737 242-251 NN denotes formation
T2738 234-241 NN denotes pattern
T2739 252-255 CC denotes and
T2740 256-269 NN denotes morphogenesis
T2741 270-272 IN denotes of
T2742 273-277 JJ denotes many
T2743 278-284 NNS denotes organs
T2744 284-286 , denotes ,
T2745 286-297 JJ denotes mechanistic
T2746 298-311 NN denotes understanding
T2747 312-314 IN denotes of
T2748 315-318 NN denotes APC
T2749 319-321 IN denotes in
T2750 322-333 NN denotes development
T2751 334-337 CC denotes and
T2752 338-340 IN denotes in
T2753 341-353 JJ denotes extracolonic
T2754 354-361 NNS denotes tissues
T2755 370-378 JJ denotes critical
T2756 379-381 TO denotes to
T2757 389-395 VB denotes assess
T2758 382-388 RBR denotes better
T2759 396-405 JJ denotes potential
T2760 414-420 NNS denotes events
T2761 406-413 JJ denotes adverse
T2762 421-423 IN denotes in
T2763 424-430 NNS denotes humans
T2764 430-431 . denotes .
T2765 431-543 sentence denotes One approach to understand the role of Apc in development is to develop mice with an inactivating Apc mutation.
T2766 432-435 CD denotes One
T2767 436-444 NN denotes approach
T2768 490-492 VBZ denotes is
T2769 445-447 TO denotes to
T2770 448-458 VB denotes understand
T2771 459-462 DT denotes the
T2772 463-467 NN denotes role
T2773 468-470 IN denotes of
T2774 471-474 NN denotes Apc
T2775 475-477 IN denotes in
T2776 478-489 NN denotes development
T2777 493-495 TO denotes to
T2778 496-503 VB denotes develop
T2779 504-508 NNS denotes mice
T2780 509-513 IN denotes with
T2781 514-516 DT denotes an
T2782 534-542 NN denotes mutation
T2783 517-529 VBG denotes inactivating
T2784 530-533 NN denotes Apc
T2785 542-543 . denotes .
T2786 543-622 sentence denotes Several genetically modified mouse strains for Apc have been described [7–10].
T2787 544-551 JJ denotes Several
T2788 579-586 NNS denotes strains
T2789 552-563 RB denotes genetically
T2790 564-572 VBN denotes modified
T2791 573-578 NN denotes mouse
T2792 605-614 VBN denotes described
T2793 587-590 IN denotes for
T2794 591-594 NN denotes Apc
T2795 595-599 VBP denotes have
T2796 600-604 VBN denotes been
T2797 615-616 -LRB- denotes [
T2798 616-617 CD denotes 7
T2799 617-618 SYM denotes –
T2800 618-620 CD denotes 10
T2801 620-621 -RRB- denotes ]
T2802 621-622 . denotes .
T2803 622-744 sentence denotes Most of these models, in the heterozygous state, show a gastrointestinal and other tumor predisposition phenotype [7–10].
T2804 623-627 JJS denotes Most
T2805 672-676 VBP denotes show
T2806 628-630 IN denotes of
T2807 631-636 DT denotes these
T2808 637-643 NNS denotes models
T2809 643-645 , denotes ,
T2810 645-647 IN denotes in
T2811 648-651 DT denotes the
T2812 665-670 NN denotes state
T2813 652-664 JJ denotes heterozygous
T2814 670-672 , denotes ,
T2815 677-678 DT denotes a
T2816 727-736 NN denotes phenotype
T2817 679-695 JJ denotes gastrointestinal
T2818 706-711 NN denotes tumor
T2819 696-699 CC denotes and
T2820 700-705 JJ denotes other
T2821 712-726 NN denotes predisposition
T2822 737-738 -LRB- denotes [
T2823 738-739 CD denotes 7
T2824 739-740 SYM denotes –
T2825 740-742 CD denotes 10
T2826 742-743 -RRB- denotes ]
T2827 743-744 . denotes .
T2828 744-899 sentence denotes Mouse embryos that are homozygous for the genetic modification die during embryogenesis, and some of the models do not survive beyond gastrulation [8,11].
T2829 745-750 NN denotes Mouse
T2830 751-758 NNS denotes embryos
T2831 808-811 VBP denotes die
T2832 759-763 WDT denotes that
T2833 764-767 VBP denotes are
T2834 768-778 JJ denotes homozygous
T2835 779-782 IN denotes for
T2836 783-786 DT denotes the
T2837 795-807 NN denotes modification
T2838 787-794 JJ denotes genetic
T2839 812-818 IN denotes during
T2840 819-832 NN denotes embryogenesis
T2841 832-834 , denotes ,
T2842 834-837 CC denotes and
T2843 838-842 DT denotes some
T2844 864-871 VB denotes survive
T2845 843-845 IN denotes of
T2846 846-849 DT denotes the
T2847 850-856 NNS denotes models
T2848 857-859 VBP denotes do
T2849 860-863 RB denotes not
T2850 872-878 IN denotes beyond
T2851 879-891 NN denotes gastrulation
T2852 892-893 -LRB- denotes [
T2853 895-897 CD denotes 11
T2854 893-894 CD denotes 8
T2855 894-895 , denotes ,
T2856 897-898 -RRB- denotes ]
T2857 898-899 . denotes .
T2858 899-1187 sentence denotes An alternate approach to understand the role of Apc in development and/or in specific tissues is to generate a mouse strain that carries a conditionally modified allele and mate it with a mouse strain that facilitates the modification of the conditional allele in specific cell lineages.
T2859 900-902 DT denotes An
T2860 913-921 NN denotes approach
T2861 903-912 JJ denotes alternate
T2862 994-996 VBZ denotes is
T2863 922-924 TO denotes to
T2864 925-935 VB denotes understand
T2865 936-939 DT denotes the
T2866 940-944 NN denotes role
T2867 945-947 IN denotes of
T2868 948-951 NN denotes Apc
T2869 952-954 IN denotes in
T2870 955-966 NN denotes development
T2871 967-970 CC denotes and
T2872 970-971 HYPH denotes /
T2873 971-973 CC denotes or
T2874 974-976 IN denotes in
T2875 977-985 JJ denotes specific
T2876 986-993 NNS denotes tissues
T2877 997-999 TO denotes to
T2878 1000-1008 VB denotes generate
T2879 1009-1010 DT denotes a
T2880 1017-1023 NN denotes strain
T2881 1011-1016 NN denotes mouse
T2882 1024-1028 WDT denotes that
T2883 1029-1036 VBZ denotes carries
T2884 1037-1038 DT denotes a
T2885 1062-1068 NN denotes allele
T2886 1039-1052 RB denotes conditionally
T2887 1053-1061 VBN denotes modified
T2888 1069-1072 CC denotes and
T2889 1073-1077 VB denotes mate
T2890 1078-1080 PRP denotes it
T2891 1081-1085 IN denotes with
T2892 1086-1087 DT denotes a
T2893 1094-1100 NN denotes strain
T2894 1088-1093 NN denotes mouse
T2895 1101-1105 WDT denotes that
T2896 1106-1117 VBZ denotes facilitates
T2897 1118-1121 DT denotes the
T2898 1122-1134 NN denotes modification
T2899 1135-1137 IN denotes of
T2900 1138-1141 DT denotes the
T2901 1154-1160 NN denotes allele
T2902 1142-1153 JJ denotes conditional
T2903 1161-1163 IN denotes in
T2904 1164-1172 JJ denotes specific
T2905 1178-1186 NNS denotes lineages
T2906 1173-1177 NN denotes cell
T2907 1186-1187 . denotes .
R551 T2696 T2697 mark Although,is
R553 T2697 T2709 advcl is,understood
R554 T2698 T2699 det the,role
R555 T2699 T2697 nsubj role,is
R557 T2700 T2699 prep of,role
R558 T2701 T2700 pobj APC,of
R559 T2702 T2699 prep in,role
R561 T2703 T2704 det the,initiation
R562 T2704 T2702 pobj initiation,in
R563 T2705 T2704 prep of,initiation
R564 T2706 T2707 amod human,cancer
R566 T2707 T2705 pobj cancer,of
R567 T2708 T2707 amod colorectal,cancer
R569 T2710 T2711 advmod well,established
R573 T2711 T2697 acomp established,is
R574 T2817 T2818 amod gastrointestinal,tumor
R575 T2712 T2709 punct ", ",understood
R576 T2713 T2714 poss its,role
R577 T2714 T2709 nsubjpass role,understood
R578 T2715 T2714 prep in,role
R579 T2716 T2717 amod other,processes
R580 T2717 T2715 pobj processes,in
R581 T2818 T2821 compound tumor,predisposition
R582 T2718 T2717 nmod tissue,processes
R583 T2719 T2718 cc and,tissue
R584 T2720 T2718 conj developmental,tissue
R585 T2819 T2817 cc and,gastrointestinal
R586 T2721 T2709 auxpass are,understood
R587 T2722 T2709 neg not,understood
R588 T2723 T2709 advmod well,understood
R589 T2820 T2817 conj other,gastrointestinal
R590 T2724 T2709 punct .,understood
R591 T2726 T2727 prep Given,becomes
R592 T2821 T2816 compound predisposition,phenotype
R593 T2728 T2729 det the,importance
R594 T2729 T2726 pobj importance,Given
R595 T2822 T2823 punct [,7
R596 T2730 T2729 prep of,importance
R597 T2731 T2730 pobj regulation,of
R598 T2732 T2731 prep of,regulation
R599 T2733 T2734 compound Wnt,signaling
R600 T2734 T2732 pobj signaling,of
R601 T2735 T2729 prep in,importance
R602 T2823 T2805 parataxis 7,show
R603 T2736 T2737 amod embryonic,formation
R604 T2737 T2735 pobj formation,in
R605 T2738 T2737 compound pattern,formation
R606 T2824 T2825 punct –,10
R607 T2739 T2737 cc and,formation
R608 T2740 T2737 conj morphogenesis,formation
R609 T2741 T2740 prep of,morphogenesis
R610 T2825 T2823 prep 10,7
R611 T2742 T2743 amod many,organs
R612 T2826 T2823 punct ],7
R613 T2827 T2805 punct .,show
R614 T2743 T2741 pobj organs,of
R615 T2744 T2727 punct ", ",becomes
R616 T2829 T2830 compound Mouse,embryos
R617 T2745 T2746 amod mechanistic,understanding
R618 T2746 T2727 nsubj understanding,becomes
R619 T2747 T2746 prep of,understanding
R620 T2748 T2747 pobj APC,of
R621 T2830 T2831 nsubj embryos,die
R622 T2749 T2748 prep in,APC
R623 T2750 T2749 pobj development,in
R624 T2751 T2749 cc and,in
R625 T2832 T2833 dep that,are
R626 T2752 T2749 conj in,in
R627 T2753 T2754 amod extracolonic,tissues
R628 T2754 T2752 pobj tissues,in
R629 T2755 T2727 acomp critical,becomes
R630 T2756 T2757 aux to,assess
R631 T2833 T2830 relcl are,embryos
R632 T2834 T2833 acomp homozygous,are
R633 T2757 T2755 xcomp assess,critical
R634 T2835 T2834 prep for,homozygous
R635 T2758 T2757 advmod better,assess
R636 T2836 T2837 det the,modification
R637 T2759 T2760 amod potential,events
R638 T2760 T2757 dobj events,assess
R639 T2761 T2760 amod adverse,events
R640 T2762 T2757 prep in,assess
R641 T2837 T2835 pobj modification,for
R642 T2763 T2762 pobj humans,in
R643 T2764 T2727 punct .,becomes
R644 T2838 T2837 amod genetic,modification
R645 T2766 T2767 nummod One,approach
R646 T2767 T2768 nsubj approach,is
R647 T2839 T2831 prep during,die
R648 T2769 T2770 aux to,understand
R649 T2840 T2839 pobj embryogenesis,during
R650 T2770 T2767 advcl understand,approach
R651 T2771 T2772 det the,role
R652 T2772 T2770 dobj role,understand
R653 T2773 T2772 prep of,role
R654 T2774 T2773 pobj Apc,of
R655 T2775 T2772 prep in,role
R656 T2841 T2831 punct ", ",die
R657 T2776 T2775 pobj development,in
R658 T2777 T2778 aux to,develop
R659 T2778 T2768 xcomp develop,is
R660 T2779 T2778 dobj mice,develop
R661 T2842 T2831 cc and,die
R662 T2780 T2779 prep with,mice
R663 T2781 T2782 det an,mutation
R664 T2843 T2844 nsubj some,survive
R665 T2782 T2780 pobj mutation,with
R666 T2783 T2782 amod inactivating,mutation
R667 T2784 T2782 compound Apc,mutation
R668 T2844 T2831 conj survive,die
R669 T2785 T2768 punct .,is
R670 T2787 T2788 amod Several,strains
R671 T2788 T2792 nsubjpass strains,described
R672 T2845 T2843 prep of,some
R673 T2789 T2790 advmod genetically,modified
R674 T2790 T2788 amod modified,strains
R675 T2791 T2788 compound mouse,strains
R676 T2846 T2847 det the,models
R677 T2793 T2788 prep for,strains
R678 T2794 T2793 pobj Apc,for
R679 T2847 T2845 pobj models,of
R680 T2795 T2792 aux have,described
R681 T2796 T2792 auxpass been,described
R682 T2797 T2798 punct [,7
R683 T2848 T2844 aux do,survive
R684 T2798 T2792 parataxis 7,described
R685 T2799 T2800 punct –,10
R686 T2800 T2798 prep 10,7
R687 T2801 T2798 punct ],7
R688 T2849 T2844 neg not,survive
R689 T2802 T2792 punct .,described
R690 T2850 T2844 prep beyond,survive
R691 T2804 T2805 nsubj Most,show
R692 T2806 T2804 prep of,Most
R693 T2851 T2850 pobj gastrulation,beyond
R694 T2807 T2808 det these,models
R695 T2808 T2806 pobj models,of
R696 T2809 T2804 punct ", ",Most
R697 T2810 T2804 prep in,Most
R698 T2852 T2853 punct [,11
R699 T2811 T2812 det the,state
R700 T2812 T2810 pobj state,in
R701 T2813 T2812 amod heterozygous,state
R702 T2853 T2844 parataxis 11,survive
R703 T2814 T2805 punct ", ",show
R704 T2815 T2816 det a,phenotype
R705 T2816 T2805 dobj phenotype,show
R706 T2854 T2853 nummod 8,11
R707 T2855 T2853 punct ",",11
R708 T2856 T2853 punct ],11
R712 T2857 T2844 punct .,survive
R714 T2859 T2860 det An,approach
R719 T2860 T2862 nsubj approach,is
R722 T2861 T2860 amod alternate,approach
R726 T2863 T2864 aux to,understand
R731 T2864 T2860 advcl understand,approach
R733 T2865 T2866 det the,role
R736 T2866 T2864 dobj role,understand
R741 T2867 T2866 prep of,role
R744 T2868 T2867 pobj Apc,of
R746 T2869 T2866 prep in,role
R751 T2870 T2869 pobj development,in
R755 T2871 T2869 cc and,in
R762 T2872 T2871 punct /,and
R766 T2873 T2871 cc or,and
R770 T2874 T2869 conj in,in
R774 T2875 T2876 amod specific,tissues
R778 T2876 T2874 pobj tissues,in
R780 T2877 T2878 aux to,generate
R784 T2878 T2862 xcomp generate,is
R788 T2879 T2880 det a,strain
R792 T2880 T2878 dobj strain,generate
R795 T2881 T2880 compound mouse,strain
R799 T2882 T2883 dep that,carries
R803 T2883 T2880 relcl carries,strain
R811 T2884 T2885 det a,allele
R815 T2885 T2883 dobj allele,carries
R819 T2886 T2887 advmod conditionally,modified
R823 T2887 T2885 amod modified,allele
R826 T2888 T2878 cc and,generate
R827 T2889 T2878 conj mate,generate
R829 T2890 T2889 dobj it,mate
R833 T2891 T2889 prep with,mate
R836 T2892 T2893 det a,strain
R839 T2893 T2891 pobj strain,with
R842 T2894 T2893 compound mouse,strain
R845 T2895 T2896 dep that,facilitates
R846 T2896 T2893 relcl facilitates,strain
R847 T2897 T2898 det the,modification
R851 T2898 T2896 dobj modification,facilitates
R854 T2899 T2898 prep of,modification
R857 T2900 T2901 det the,allele
R864 T2901 T2899 pobj allele,of
R869 T2902 T2901 amod conditional,allele
R873 T2903 T2898 prep in,modification
R876 T2904 T2905 amod specific,lineages
R880 T2905 T2903 pobj lineages,in
R884 T2906 T2905 compound cell,lineages
R888 T2907 T2862 punct .,is

2_test

Id Subject Object Predicate Lexical cue
17002498-7753829-85593496 616-617 7753829 denotes 7
17002498-7576992-85593496 616-617 7576992 denotes 7
17002498-9054624-85593496 616-617 9054624 denotes 7
17002498-8090754-85593496 616-617 8090754 denotes 7
17002498-9054624-85593497 738-739 9054624 denotes 7
17002498-7753829-85593497 738-739 7753829 denotes 7
17002498-7576992-85593497 738-739 7576992 denotes 7
17002498-8090754-85593497 738-739 8090754 denotes 7
17002498-7753829-85593498 893-894 7753829 denotes 8
17002498-12645927-85593499 895-897 12645927 denotes 11
T45080 616-617 9054624 denotes 7
T40102 616-617 7753829 denotes 7
T88630 616-617 7576992 denotes 7
T58268 616-617 8090754 denotes 7
T41070 738-739 9054624 denotes 7
T43862 738-739 7753829 denotes 7
T10199 738-739 7576992 denotes 7
T88104 738-739 8090754 denotes 7
T81088 893-894 7753829 denotes 8
T78076 895-897 12645927 denotes 11