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PMC:1564426 / 39058-43938 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21900 18-31 UBERON:0002073 denotes hair follicle
T21901 18-43 GO:0001942 denotes hair follicle development
T21902 97-105 UBERON_EXT:placode denotes placodes
T21903 121-131 UBERON:0000483 denotes epithelium
T21904 135-143 GO_EXT:reaction_or_response denotes response
T21905 157-163 UBERON_EXT:skin_or_dermis denotes dermal
T21906 220-229 CHEBI:36357 denotes molecules
T21907 254-261 UBERON_EXT:placode denotes placode
T21908 327-348 GO:0016055 denotes Wnt signaling pathway
T21909 356-362 UBERON:0002067 denotes dermis
T21910 405-411 UBERON_EXT:skin_or_dermis denotes dermal
T21911 447-457 UBERON:0000483 denotes epithelial
T21912 458-467 PR_EXT:000002198 denotes β-catenin
T21913 468-477 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21914 482-492 GO:0010467 denotes expression
T21915 496-506 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T21916 507-516 SO_EXT:sequence_truncation_process denotes truncated
T21917 553-562 PR_EXT:000002198 denotes β-catenin
T21918 574-584 GO:0010467 denotes expression
T21919 588-592 PR_EXT:000009751 denotes Lef1
T21920 610-619 UBERON_EXT:follicle denotes follicles
T21921 628-633 NCBITaxon:10088 denotes mouse
T21922 638-643 NCBITaxon_UBERON_EXT:chick denotes chick
T21923 644-648 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T21924 670-685 GO_EXT:negative_regulation denotes down-regulation
T21925 689-698 PR_EXT:000002198 denotes β-catenin
T21926 699-708 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21927 718-722 PR_EXT:000009751 denotes Lef1
T21928 742-752 GO:0010467 denotes expression
T21929 760-769 CHEBI_EXT:35222 denotes inhibitor
T21930 770-774 PR_EXT:000006499 denotes Dkk1
T21931 790-798 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T21932 802-811 PR_EXT:000002198 denotes β-catenin
T21933 815-824 UBERON:0007376 denotes epidermis
T21934 845-854 UBERON:0010419 denotes vibrissae
T21935 864-870 UBERON:0010509 denotes pelage
T21936 871-880 UBERON_EXT:follicle denotes follicles
T21937 884-888 NCBITaxon:10088 denotes mice
T21938 915-918 PR_EXT:000009454 denotes K14
T21939 926-929 PR_EXT:000004122 denotes Apc
T21940 938-956 UBERON:0000924 denotes embryonic ectoderm
T21941 1025-1037 UBERON:0005086 denotes hair placode
T21942 1053-1061 UBERON_EXT:follicle denotes follicle
T21943 1062-1075 GO:0009653 denotes morphogenesis
T21944 1147-1157 UBERON:0008281 denotes tooth buds
T21945 1228-1238 UBERON:0000483 denotes epithelial
T21946 1239-1248 PR_EXT:000002198 denotes β-catenin
T21947 1249-1258 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21948 1266-1273 UBERON_EXT:placode denotes placode
T21949 1308-1311 PR_EXT:000004122 denotes Apc
T21950 1315-1331 _FRAGMENT denotes specification of
T21951 1353-1363 GO:0048866 denotes stem cells
T21952 1342-1352 _FRAGMENT denotes ectodermal
T21953 1358-1363 GO:0001715 denotes cells
T21954 1332-1352 UBERON:0000924 denotes embryonic ectodermal
T21955 1332-1341 _FRAGMENT denotes embryonic
T21956 1353-1363 CL:0002322 denotes stem cells
T21957 1358-1363 CL:0000221 denotes cells
T21958 1358-1363 CL_GO_EXT:cell denotes cells
T21959 1377-1390 UBERON:0002073 denotes hair follicle
T21960 1410-1413 PR_EXT:000004122 denotes Apc
T21961 1417-1432 GO_EXT:negative_regulation denotes down-regulation
T21962 1436-1445 PR_EXT:000002198 denotes β-catenin
T21963 1455-1458 PR_EXT:000004122 denotes Apc
T21964 1492-1502 GO:0010467 denotes expression
T21965 1506-1515 PR_EXT:000002198 denotes β-catenin
T21966 1519-1529 UBERON:0000924 denotes ectodermal
T21967 1519-1535 CL:0000221 denotes ectodermal cells
T21968 1530-1535 CL_GO_EXT:cell denotes cells
T21969 1547-1559 UBERON:0005086 denotes hair placode
T21970 1547-1569 GO:0060789 denotes hair placode formation
T21971 1595-1605 UBERON_EXT:follicle denotes follicular
T21972 1606-1612 GO_EXT:biological_growth_entity_or_process denotes growth
T21973 1628-1637 UBERON:0000922 denotes embryonic
T21974 1638-1647 UBERON:0007376 denotes epidermis
T21975 1663-1671 UBERON:0013623 denotes footpads
T21976 1688-1692 UBERON:0001037 denotes hair
T21977 1801-1807 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T21978 1808-1812 NCBITaxon:10088 denotes mice
T21979 1842-1845 PR_EXT:000009454 denotes K14
T21980 1855-1865 SO_EXT:transgenic_entity denotes transgenic
T21981 1866-1870 NCBITaxon:10088 denotes mice
T21982 1871-1881 GO:0010467 denotes expressing
T21983 1889-1898 PR_EXT:000002198 denotes β-catenin
T21984 1909-1916 GO:0065007 denotes control
T21985 1920-1923 PR_EXT:000009454 denotes K14
T21986 1924-1932 SO_EXT:0000167 denotes promoter
T21987 1942-1945 PR_EXT:000009454 denotes K14
T21988 1946-1950 PR_EXT:000009751 denotes Lef1
T21989 1951-1961 SO_EXT:transgenic_entity denotes transgenic
T21990 1962-1966 NCBITaxon:10088 denotes mice
T21991 1991-1997 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T21992 1998-2002 NCBITaxon:10088 denotes mice
T21993 2037-2040 PR_EXT:000009454 denotes K14
T21994 2041-2045 PR_EXT:000009751 denotes Lef1
T21995 2046-2050 NCBITaxon:10088 denotes mice
T21996 2060-2063 PR_EXT:000009454 denotes K14
T21997 2073-2083 SO_EXT:transgenic_entity denotes transgenic
T21998 2084-2088 NCBITaxon:10088 denotes mice
T21999 2110-2116 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22000 2117-2121 NCBITaxon:10088 denotes mice
T22001 2182-2185 PR_EXT:000009454 denotes K14
T22002 2201-2204 PR_EXT:000009454 denotes K14
T22003 2214-2224 SO_EXT:transgenic_entity denotes transgenic
T22004 2225-2229 NCBITaxon:10088 denotes mice
T22005 2247-2253 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22006 2254-2258 NCBITaxon:10088 denotes mice
T22007 2284-2293 UBERON:0010166 denotes hair coat
T22008 2326-2334 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T22009 2335-2340 UBERON:0001037 denotes hairs
T22010 2370-2373 PR_EXT:000009454 denotes K14
T22011 2374-2378 PR_EXT:000009751 denotes Lef1
T22012 2379-2383 NCBITaxon:10088 denotes mice
T22013 2396-2399 PR_EXT:000009454 denotes K14
T22014 2409-2413 NCBITaxon:10088 denotes mice
T22015 2415-2424 UBERON:0000922 denotes embryonic
T22016 2415-2424 _FRAGMENT denotes embryonic
T22017 2439-2452 GO:0048598 denotes morphogenesis
T22018 2425-2438 UBERON:0002073 denotes hair follicle
T22019 2425-2452 GO:0031069 denotes hair follicle morphogenesis
T22020 2478-2482 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22021 2508-2515 GO:0007567 denotes natally
T22022 2639-2642 PR_EXT:000009454 denotes K14
T22023 2643-2651 SO_EXT:0000167 denotes promoter
T22024 2684-2694 GO:0010467 denotes expression
T22025 2786-2796 GO:0010467 denotes expression
T22026 2800-2808 SO_EXT:0000167 denotes promoter
T22027 2809-2818 SO_EXT:0000902 denotes transgene
T22028 2819-2828 SO_EXT:engineered_biological_sequence denotes construct
T22029 2832-2842 SO_EXT:transgenic_entity denotes transgenic
T22030 2843-2847 NCBITaxon:10088 denotes mice
T22031 2909-2925 SO_EXT:0000366 denotes integration site
T22032 2933-2942 SO_EXT:0000902 denotes transgene
T22033 2950-2955 NCBITaxon:10088 denotes mouse
T22034 2956-2962 SO_EXT:0001026 denotes genome
T22035 2981-3004 SO_EXT:0000366 denotes location of integration
T22036 3010-3025 GO_EXT:transcription denotes transcriptional
T22037 3052-3061 SO_EXT:0000902 denotes transgene
T22038 3149-3162 GO:0009790 denotes embryogenesis
T22039 3199-3209 GO:0010467 denotes expression
T22040 3217-3220 PR_EXT:000009454 denotes K14
T22041 3230-3239 SO_EXT:0000902 denotes transgene
T22042 3266-3274 SO_EXT:0000167 denotes promoter
T22043 3302-3315 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T22044 3333-3337 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22045 3341-3344 PR_EXT:000009454 denotes K14
T22046 3349-3359 SO_EXT:transgenic_entity denotes transgenic
T22047 3360-3364 NCBITaxon:10088 denotes mice
T22048 3393-3396 PR_EXT:000009454 denotes K14
T22049 3410-3420 SO_EXT:sequence_truncation_entity_or_process denotes truncation
T22050 3428-3431 PR_EXT:000004122 denotes Apc
T22051 3432-3436 SO_EXT:0000704 denotes gene
T22052 3504-3517 UBERON:0002073 denotes hair follicle
T22053 3504-3530 GO:0031069 denotes hair follicle morphgenesis
T22054 3589-3599 SO_EXT:transgenic_entity denotes transgenic
T22055 3614-3624 GO:0010467 denotes expression
T22056 3628-3637 SO_EXT:0000902 denotes transgene
T22057 3657-3671 _FRAGMENT denotes basal cells of
T22058 3676-3685 CL:0002187 denotes epidermis
T22059 3663-3668 CL_GO_EXT:cell denotes cells
T22060 3663-3671 _FRAGMENT denotes cells of
T22061 3694-3715 CL:0002561 denotes ORS of hair follicles
T22062 3676-3685 UBERON:0007376 denotes epidermis
T22063 3694-3715 UBERON:0005942 denotes ORS of hair follicles
T22064 3727-3730 PR_EXT:000009454 denotes K14
T22065 3731-3739 SO_EXT:0000167 denotes promoter
T22066 3755-3765 GO:0010467 denotes expression
T22067 3769-3778 SO_EXT:0000902 denotes transgene
T22068 3813-3816 PR_EXT:000009454 denotes K14
T22069 3817-3827 GO:0010467 denotes expressing
T22070 3828-3833 CL_GO_EXT:cell denotes cells
T22071 3845-3858 GO_RO_EXT:developmental_differentiation_process denotes differentiate
T22072 3887-3890 PR_EXT:000009454 denotes K14
T22073 3904-3912 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T22074 3916-3919 PR_EXT:000004122 denotes Apc
T22075 3936-3939 PR_EXT:000004122 denotes Apc
T22076 3940-3948 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T22077 3961-3964 PR_EXT:000009454 denotes K14
T22078 3965-3973 SO_EXT:0000167 denotes promoter
T22079 3981-3986 CL_GO_EXT:cell denotes cells
T22080 4009-4013 CL_GO_EXT:cell denotes cell
T22081 4009-4020 UBERON:0000119 denotes cell layers
T22082 4043-4046 PR_EXT:000009454 denotes K14
T22083 4047-4055 SO_EXT:0000167 denotes promoter
T22084 4106-4126 UBERON:0010402 denotes suprabasal epidermis
T22085 4142-4152 UBERON:0000483 denotes epithelium
T22086 4160-4173 UBERON:0002073 denotes hair follicle
T22087 4192-4201 PR_EXT:000002198 denotes β-catenin
T22088 4215-4234 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes population of cells
T22089 4229-4234 CL_GO_EXT:cell denotes cells
T22090 4329-4338 PR_EXT:000002198 denotes β-catenin
T22091 4339-4349 GO:0010467 denotes expression
T22092 4360-4362 PR_EXT:000009450 denotes K1
T22093 4367-4369 PR_EXT:keratin_6 denotes K6
T22094 4379-4393 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T22095 4394-4399 CL_GO_EXT:cell denotes cells
T22096 4407-4412 GO:0007567 denotes natal
T22097 4413-4419 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22098 4420-4424 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22099 4469-4472 PR_EXT:000004122 denotes Apc
T22100 4504-4513 PR_EXT:000002198 denotes β-catenin
T22101 4532-4535 PR_EXT:000009454 denotes K14
T22102 4536-4546 GO:0010467 denotes expressing
T22103 4569-4578 PR_EXT:000002198 denotes β-catenin
T22104 4579-4589 GO:0010467 denotes expression
T22105 4606-4610 CL_GO_EXT:cell denotes cell
T22106 4606-4629 GO:0001709 denotes cell fate determination
T22107 4653-4664 CL:0000646 denotes basal cells
T22108 4659-4664 CL_GO_EXT:cell denotes cells
T22109 4749-4752 PR_EXT:000004122 denotes Apc
T22110 4793-4808 GO_EXT:negative_regulation denotes down-regulation
T22111 4812-4821 PR_EXT:000002198 denotes β-catenin
R5945 T21951 T21950 _lexicallyChainedTo stem cells,specification of
R5946 T21952 T21950 _lexicallyChainedTo ectodermal,specification of
R5947 T21953 T21952 _lexicallyChainedTo cells,ectodermal
R5948 T21956 T21955 _lexicallyChainedTo stem cells,embryonic
R5949 T21957 T21952 _lexicallyChainedTo cells,ectodermal
R5950 T22017 T22016 _lexicallyChainedTo morphogenesis,embryonic
R5951 T22058 T22057 _lexicallyChainedTo epidermis,basal cells of
R5952 T22061 T22060 _lexicallyChainedTo ORS of hair follicles,cells of

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21689 18-31 UBERON:0002073 denotes hair follicle
T21690 18-43 GO:0001942 denotes hair follicle development
T21691 121-131 UBERON:0000483 denotes epithelium
T21692 220-229 CHEBI:36357 denotes molecules
T21693 327-348 GO:0016055 denotes Wnt signaling pathway
T21694 356-362 UBERON:0002067 denotes dermis
T21695 447-457 UBERON:0000483 denotes epithelial
T21696 458-467 PR:000002198 denotes β-catenin
T21697 482-492 GO:0010467 denotes expression
T21698 553-562 PR:000002198 denotes β-catenin
T21699 574-584 GO:0010467 denotes expression
T21700 588-592 PR:000009751 denotes Lef1
T21701 628-633 NCBITaxon:10088 denotes mouse
T21702 689-698 PR:000002198 denotes β-catenin
T21703 718-722 PR:000009751 denotes Lef1
T21704 742-752 GO:0010467 denotes expression
T21705 760-769 CHEBI:35222 denotes inhibitor
T21706 770-774 PR:000006499 denotes Dkk1
T21707 802-811 PR:000002198 denotes β-catenin
T21708 815-824 UBERON:0007376 denotes epidermis
T21709 845-854 UBERON:0010419 denotes vibrissae
T21710 864-870 UBERON:0010509 denotes pelage
T21711 884-888 NCBITaxon:10088 denotes mice
T21712 915-918 PR:000009454 denotes K14
T21713 926-929 PR:000004122 denotes Apc
T21714 938-956 UBERON:0000924 denotes embryonic ectoderm
T21715 1025-1037 UBERON:0005086 denotes hair placode
T21716 1062-1075 GO:0009653 denotes morphogenesis
T21717 1147-1157 UBERON:0008281 denotes tooth buds
T21718 1228-1238 UBERON:0000483 denotes epithelial
T21719 1239-1248 PR:000002198 denotes β-catenin
T21720 1308-1311 PR:000004122 denotes Apc
T21721 1315-1331 _FRAGMENT denotes specification of
T21722 1353-1363 GO:0048866 denotes stem cells
T21723 1342-1352 _FRAGMENT denotes ectodermal
T21724 1358-1363 GO:0001715 denotes cells
T21725 1332-1352 UBERON:0000924 denotes embryonic ectodermal
T21726 1332-1341 _FRAGMENT denotes embryonic
T21727 1353-1363 CL:0002322 denotes stem cells
T21728 1358-1363 CL:0000221 denotes cells
T21729 1377-1390 UBERON:0002073 denotes hair follicle
T21730 1410-1413 PR:000004122 denotes Apc
T21731 1436-1445 PR:000002198 denotes β-catenin
T21732 1455-1458 PR:000004122 denotes Apc
T21733 1492-1502 GO:0010467 denotes expression
T21734 1506-1515 PR:000002198 denotes β-catenin
T21735 1519-1529 UBERON:0000924 denotes ectodermal
T21736 1519-1535 CL:0000221 denotes ectodermal cells
T21737 1547-1559 UBERON:0005086 denotes hair placode
T21738 1547-1569 GO:0060789 denotes hair placode formation
T21739 1628-1637 UBERON:0000922 denotes embryonic
T21740 1638-1647 UBERON:0007376 denotes epidermis
T21741 1663-1671 UBERON:0013623 denotes footpads
T21742 1688-1692 UBERON:0001037 denotes hair
T21743 1808-1812 NCBITaxon:10088 denotes mice
T21744 1842-1845 PR:000009454 denotes K14
T21745 1866-1870 NCBITaxon:10088 denotes mice
T21746 1871-1881 GO:0010467 denotes expressing
T21747 1889-1898 PR:000002198 denotes β-catenin
T21748 1909-1916 GO:0065007 denotes control
T21749 1920-1923 PR:000009454 denotes K14
T21750 1924-1932 SO:0000167 denotes promoter
T21751 1942-1945 PR:000009454 denotes K14
T21752 1946-1950 PR:000009751 denotes Lef1
T21753 1962-1966 NCBITaxon:10088 denotes mice
T21754 1998-2002 NCBITaxon:10088 denotes mice
T21755 2037-2040 PR:000009454 denotes K14
T21756 2041-2045 PR:000009751 denotes Lef1
T21757 2046-2050 NCBITaxon:10088 denotes mice
T21758 2060-2063 PR:000009454 denotes K14
T21759 2084-2088 NCBITaxon:10088 denotes mice
T21760 2117-2121 NCBITaxon:10088 denotes mice
T21761 2182-2185 PR:000009454 denotes K14
T21762 2201-2204 PR:000009454 denotes K14
T21763 2225-2229 NCBITaxon:10088 denotes mice
T21764 2254-2258 NCBITaxon:10088 denotes mice
T21765 2284-2293 UBERON:0010166 denotes hair coat
T21766 2335-2340 UBERON:0001037 denotes hairs
T21767 2370-2373 PR:000009454 denotes K14
T21768 2374-2378 PR:000009751 denotes Lef1
T21769 2379-2383 NCBITaxon:10088 denotes mice
T21770 2396-2399 PR:000009454 denotes K14
T21771 2409-2413 NCBITaxon:10088 denotes mice
T21772 2415-2424 UBERON:0000922 denotes embryonic
T21773 2415-2424 _FRAGMENT denotes embryonic
T21774 2439-2452 GO:0048598 denotes morphogenesis
T21775 2425-2438 UBERON:0002073 denotes hair follicle
T21776 2425-2452 GO:0031069 denotes hair follicle morphogenesis
T21777 2508-2515 GO:0007567 denotes natally
T21778 2639-2642 PR:000009454 denotes K14
T21779 2643-2651 SO:0000167 denotes promoter
T21780 2684-2694 GO:0010467 denotes expression
T21781 2786-2796 GO:0010467 denotes expression
T21782 2800-2808 SO:0000167 denotes promoter
T21783 2809-2818 SO:0000902 denotes transgene
T21784 2843-2847 NCBITaxon:10088 denotes mice
T21785 2909-2925 SO:0000366 denotes integration site
T21786 2933-2942 SO:0000902 denotes transgene
T21787 2950-2955 NCBITaxon:10088 denotes mouse
T21788 2956-2962 SO:0001026 denotes genome
T21789 2981-3004 SO:0000366 denotes location of integration
T21790 3052-3061 SO:0000902 denotes transgene
T21791 3149-3162 GO:0009790 denotes embryogenesis
T21792 3199-3209 GO:0010467 denotes expression
T21793 3217-3220 PR:000009454 denotes K14
T21794 3230-3239 SO:0000902 denotes transgene
T21795 3266-3274 SO:0000167 denotes promoter
T21796 3341-3344 PR:000009454 denotes K14
T21797 3360-3364 NCBITaxon:10088 denotes mice
T21798 3393-3396 PR:000009454 denotes K14
T21799 3428-3431 PR:000004122 denotes Apc
T21800 3432-3436 SO:0000704 denotes gene
T21801 3504-3517 UBERON:0002073 denotes hair follicle
T21802 3504-3530 GO:0031069 denotes hair follicle morphgenesis
T21803 3614-3624 GO:0010467 denotes expression
T21804 3628-3637 SO:0000902 denotes transgene
T21805 3657-3671 _FRAGMENT denotes basal cells of
T21806 3676-3685 CL:0002187 denotes epidermis
T21807 3663-3671 _FRAGMENT denotes cells of
T21808 3694-3715 CL:0002561 denotes ORS of hair follicles
T21809 3676-3685 UBERON:0007376 denotes epidermis
T21810 3694-3715 UBERON:0005942 denotes ORS of hair follicles
T21811 3727-3730 PR:000009454 denotes K14
T21812 3731-3739 SO:0000167 denotes promoter
T21813 3755-3765 GO:0010467 denotes expression
T21814 3769-3778 SO:0000902 denotes transgene
T21815 3813-3816 PR:000009454 denotes K14
T21816 3817-3827 GO:0010467 denotes expressing
T21817 3887-3890 PR:000009454 denotes K14
T21818 3916-3919 PR:000004122 denotes Apc
T21819 3936-3939 PR:000004122 denotes Apc
T21820 3961-3964 PR:000009454 denotes K14
T21821 3965-3973 SO:0000167 denotes promoter
T21822 4009-4020 UBERON:0000119 denotes cell layers
T21823 4043-4046 PR:000009454 denotes K14
T21824 4047-4055 SO:0000167 denotes promoter
T21825 4106-4126 UBERON:0010402 denotes suprabasal epidermis
T21826 4142-4152 UBERON:0000483 denotes epithelium
T21827 4160-4173 UBERON:0002073 denotes hair follicle
T21828 4192-4201 PR:000002198 denotes β-catenin
T21829 4329-4338 PR:000002198 denotes β-catenin
T21830 4339-4349 GO:0010467 denotes expression
T21831 4360-4362 PR:000009450 denotes K1
T21832 4407-4412 GO:0007567 denotes natal
T21833 4469-4472 PR:000004122 denotes Apc
T21834 4504-4513 PR:000002198 denotes β-catenin
T21835 4532-4535 PR:000009454 denotes K14
T21836 4536-4546 GO:0010467 denotes expressing
T21837 4569-4578 PR:000002198 denotes β-catenin
T21838 4579-4589 GO:0010467 denotes expression
T21839 4606-4629 GO:0001709 denotes cell fate determination
T21840 4653-4664 CL:0000646 denotes basal cells
T21841 4749-4752 PR:000004122 denotes Apc
T21842 4812-4821 PR:000002198 denotes β-catenin
R5936 T21722 T21721 _lexicallyChainedTo stem cells,specification of
R5937 T21723 T21721 _lexicallyChainedTo ectodermal,specification of
R5938 T21724 T21723 _lexicallyChainedTo cells,ectodermal
R5939 T21727 T21726 _lexicallyChainedTo stem cells,embryonic
R5940 T21728 T21723 _lexicallyChainedTo cells,ectodermal
R5941 T21774 T21773 _lexicallyChainedTo morphogenesis,embryonic
R5942 T21806 T21805 _lexicallyChainedTo epidermis,basal cells of
R5943 T21808 T21807 _lexicallyChainedTo ORS of hair follicles,cells of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T22189 0-7 JJ denotes Current
T22190 8-14 NNS denotes models
T22191 44-51 VBP denotes suggest
T22192 15-17 IN denotes of
T22193 18-22 NN denotes hair
T22194 23-31 NN denotes follicle
T22195 32-43 NN denotes development
T22196 52-56 IN denotes that
T22197 175-183 VBN denotes achieved
T22198 57-60 DT denotes the
T22199 61-74 NN denotes establishment
T22200 75-77 IN denotes of
T22201 78-79 DT denotes a
T22202 88-93 NN denotes array
T22203 80-87 JJ denotes regular
T22204 94-96 IN denotes of
T22205 97-105 NNS denotes placodes
T22206 106-108 IN denotes in
T22207 109-112 DT denotes the
T22208 121-131 NN denotes epithelium
T22209 113-120 NN denotes surface
T22210 132-134 IN denotes in
T22211 135-143 NN denotes response
T22212 144-146 IN denotes to
T22213 147-150 DT denotes the
T22214 164-171 NN denotes message
T22215 151-156 JJ denotes first
T22216 157-163 JJ denotes dermal
T22217 172-174 VBZ denotes is
T22218 184-191 IN denotes through
T22219 192-195 DT denotes the
T22220 206-216 NNS denotes activities
T22221 196-205 VBG denotes competing
T22222 217-219 IN denotes of
T22223 220-229 NNS denotes molecules
T22224 230-234 WDT denotes that
T22225 235-242 VBP denotes promote
T22226 243-245 CC denotes or
T22227 246-253 VBP denotes repress
T22228 254-261 NN denotes placode
T22229 262-266 NN denotes fate
T22230 267-268 -LRB- denotes [
T22231 268-270 CD denotes 24
T22232 270-271 -RRB- denotes ]
T22233 271-272 . denotes .
T22234 272-419 sentence denotes There is accumulating evidence that activation of the Wnt signaling pathway in the dermis may be involved in establishing the first dermal signal.
T22235 273-278 EX denotes There
T22236 279-281 VBZ denotes is
T22237 282-294 VBG denotes accumulating
T22238 295-303 NN denotes evidence
T22239 304-308 IN denotes that
T22240 370-378 VBN denotes involved
T22241 309-319 NN denotes activation
T22242 320-322 IN denotes of
T22243 323-326 DT denotes the
T22244 341-348 NN denotes pathway
T22245 327-330 NN denotes Wnt
T22246 331-340 NN denotes signaling
T22247 349-351 IN denotes in
T22248 352-355 DT denotes the
T22249 356-362 NN denotes dermis
T22250 363-366 MD denotes may
T22251 367-369 VB denotes be
T22252 379-381 IN denotes in
T22253 382-394 VBG denotes establishing
T22254 395-398 DT denotes the
T22255 412-418 NN denotes signal
T22256 399-404 JJ denotes first
T22257 405-411 JJ denotes dermal
T22258 418-419 . denotes .
T22259 419-657 sentence denotes Experimental activation of epithelial β-catenin signaling (by expression of N-terminal–truncated, constitutively stabilized forms of β-catenin or ectopic expression of Lef1) induces ectopic follicles in both mouse and chick skin [25–27].
T22260 420-432 JJ denotes Experimental
T22261 433-443 NN denotes activation
T22262 594-601 VBZ denotes induces
T22263 444-446 IN denotes of
T22264 447-457 JJ denotes epithelial
T22265 468-477 NN denotes signaling
T22266 458-459 NN denotes β
T22267 460-467 NN denotes catenin
T22268 459-460 HYPH denotes -
T22269 478-479 -LRB- denotes (
T22270 479-481 IN denotes by
T22271 482-492 NN denotes expression
T22272 493-495 IN denotes of
T22273 496-497 NN denotes N
T22274 498-506 NN denotes terminal
T22275 497-498 HYPH denotes -
T22276 507-516 JJ denotes truncated
T22277 506-507 HYPH denotes –
T22278 544-549 NNS denotes forms
T22279 516-518 , denotes ,
T22280 518-532 RB denotes constitutively
T22281 533-543 VBN denotes stabilized
T22282 550-552 IN denotes of
T22283 553-554 NN denotes β
T22284 555-562 NN denotes catenin
T22285 554-555 HYPH denotes -
T22286 563-565 CC denotes or
T22287 566-573 JJ denotes ectopic
T22288 574-584 NN denotes expression
T22289 585-587 IN denotes of
T22290 588-592 NN denotes Lef1
T22291 592-593 -RRB- denotes )
T22292 602-609 JJ denotes ectopic
T22293 610-619 NNS denotes follicles
T22294 620-622 IN denotes in
T22295 623-627 CC denotes both
T22296 628-633 NN denotes mouse
T22297 644-648 NN denotes skin
T22298 634-637 CC denotes and
T22299 638-643 NN denotes chick
T22300 649-650 -LRB- denotes [
T22301 650-652 CD denotes 25
T22302 652-653 SYM denotes –
T22303 653-655 CD denotes 27
T22304 655-656 -RRB- denotes ]
T22305 656-657 . denotes .
T22306 657-897 sentence denotes Conversely, down-regulation of β-catenin signaling (through Lef1 knock-out, ectopic expression of Wnt inhibitor Dkk1 or conditional deletion of β-catenin in epidermis) results in loss of vibrissae and some pelage follicles in mice [28–30].
T22307 658-668 RB denotes Conversely
T22308 826-833 VBZ denotes results
T22309 668-670 , denotes ,
T22310 670-674 JJ denotes down
T22311 675-685 NN denotes regulation
T22312 674-675 HYPH denotes -
T22313 686-688 IN denotes of
T22314 689-690 NN denotes β
T22315 691-698 NN denotes catenin
T22316 690-691 HYPH denotes -
T22317 699-708 NN denotes signaling
T22318 709-710 -LRB- denotes (
T22319 710-717 IN denotes through
T22320 718-722 NN denotes Lef1
T22321 723-728 VB denotes knock
T22322 742-752 NN denotes expression
T22323 728-729 HYPH denotes -
T22324 729-732 RP denotes out
T22325 732-734 , denotes ,
T22326 734-741 JJ denotes ectopic
T22327 753-755 IN denotes of
T22328 756-759 NN denotes Wnt
T22329 760-769 NN denotes inhibitor
T22330 770-774 NN denotes Dkk1
T22331 775-777 CC denotes or
T22332 778-789 JJ denotes conditional
T22333 790-798 NN denotes deletion
T22334 799-801 IN denotes of
T22335 802-803 NN denotes β
T22336 804-811 NN denotes catenin
T22337 803-804 HYPH denotes -
T22338 812-814 IN denotes in
T22339 815-824 NN denotes epidermis
T22340 824-825 -RRB- denotes )
T22341 834-836 IN denotes in
T22342 837-841 NN denotes loss
T22343 842-844 IN denotes of
T22344 845-854 NNS denotes vibrissae
T22345 855-858 CC denotes and
T22346 859-863 DT denotes some
T22347 871-880 NNS denotes follicles
T22348 864-870 NN denotes pelage
T22349 881-883 IN denotes in
T22350 884-888 NNS denotes mice
T22351 889-890 -LRB- denotes [
T22352 890-892 CD denotes 28
T22353 892-893 SYM denotes –
T22354 893-895 CD denotes 30
T22355 895-896 -RRB- denotes ]
T22356 896-897 . denotes .
T22357 897-1391 sentence denotes Our finding that K14-driven Apc loss in embryonic ectoderm resulted in irregularly spaced and often tightly clustered abnormal hair placode initiation and follicle morphogenesis (Figures 4F, 5B, 5D, and 5F) as well as in the development of multiple tooth buds (Figure 4O and 4P), is in line with the effects seen in activation of epithelial β-catenin signaling during placode formation, indicating the role of Apc in specification of embryonic ectodermal stem cells to produce a hair follicle.
T22358 898-901 PRP$ denotes Our
T22359 902-909 NN denotes finding
T22360 1178-1180 VBZ denotes is
T22361 910-914 IN denotes that
T22362 957-965 VBD denotes resulted
T22363 915-918 NN denotes K14
T22364 919-925 VBN denotes driven
T22365 918-919 HYPH denotes -
T22366 930-934 NN denotes loss
T22367 926-929 NN denotes Apc
T22368 935-937 IN denotes in
T22369 938-947 JJ denotes embryonic
T22370 948-956 NN denotes ectoderm
T22371 966-968 IN denotes in
T22372 969-980 RB denotes irregularly
T22373 981-987 VBN denotes spaced
T22374 1038-1048 NN denotes initiation
T22375 988-991 CC denotes and
T22376 992-997 RB denotes often
T22377 1006-1015 VBN denotes clustered
T22378 998-1005 RB denotes tightly
T22379 1016-1024 JJ denotes abnormal
T22380 1025-1029 NN denotes hair
T22381 1030-1037 NN denotes placode
T22382 1049-1052 CC denotes and
T22383 1053-1061 NN denotes follicle
T22384 1062-1075 NN denotes morphogenesis
T22385 1076-1077 -LRB- denotes (
T22386 1085-1087 NN denotes 4F
T22387 1077-1084 NNS denotes Figures
T22388 1087-1089 , denotes ,
T22389 1089-1091 NN denotes 5B
T22390 1091-1093 , denotes ,
T22391 1093-1095 NN denotes 5D
T22392 1095-1097 , denotes ,
T22393 1097-1100 CC denotes and
T22394 1101-1103 NN denotes 5F
T22395 1103-1104 -RRB- denotes )
T22396 1105-1107 RB denotes as
T22397 1113-1115 IN denotes as
T22398 1108-1112 RB denotes well
T22399 1116-1118 IN denotes in
T22400 1119-1122 DT denotes the
T22401 1123-1134 NN denotes development
T22402 1135-1137 IN denotes of
T22403 1138-1146 JJ denotes multiple
T22404 1153-1157 NNS denotes buds
T22405 1147-1152 NN denotes tooth
T22406 1158-1159 -LRB- denotes (
T22407 1166-1168 NN denotes 4O
T22408 1159-1165 NN denotes Figure
T22409 1169-1172 CC denotes and
T22410 1173-1175 NN denotes 4P
T22411 1175-1176 -RRB- denotes )
T22412 1176-1178 , denotes ,
T22413 1181-1183 IN denotes in
T22414 1184-1188 NN denotes line
T22415 1189-1193 IN denotes with
T22416 1194-1197 DT denotes the
T22417 1198-1205 NNS denotes effects
T22418 1206-1210 VBN denotes seen
T22419 1211-1213 IN denotes in
T22420 1214-1224 NN denotes activation
T22421 1225-1227 IN denotes of
T22422 1228-1238 JJ denotes epithelial
T22423 1249-1258 NN denotes signaling
T22424 1239-1240 NN denotes β
T22425 1241-1248 NN denotes catenin
T22426 1240-1241 HYPH denotes -
T22427 1259-1265 IN denotes during
T22428 1266-1273 NN denotes placode
T22429 1274-1283 NN denotes formation
T22430 1283-1285 , denotes ,
T22431 1285-1295 VBG denotes indicating
T22432 1296-1299 DT denotes the
T22433 1300-1304 NN denotes role
T22434 1305-1307 IN denotes of
T22435 1308-1311 NN denotes Apc
T22436 1312-1314 IN denotes in
T22437 1315-1328 NN denotes specification
T22438 1329-1331 IN denotes of
T22439 1332-1341 JJ denotes embryonic
T22440 1358-1363 NNS denotes cells
T22441 1342-1352 JJ denotes ectodermal
T22442 1353-1357 NN denotes stem
T22443 1364-1366 TO denotes to
T22444 1367-1374 VB denotes produce
T22445 1375-1376 DT denotes a
T22446 1382-1390 NN denotes follicle
T22447 1377-1381 NN denotes hair
T22448 1390-1391 . denotes .
T22449 1391-1725 sentence denotes Given the role of Apc in down-regulation of β-catenin, loss of Apc would inevitably lead to altered expression of β-catenin in ectodermal cells during the hair placode formation, giving rise to aberrant follicular growth throughout the embryonic epidermis, including the footpads, where normally hairless (Figure 5B, 5D, 5F, and 5H).
T22450 1392-1397 VBN denotes Given
T22451 1476-1480 VB denotes lead
T22452 1398-1401 DT denotes the
T22453 1402-1406 NN denotes role
T22454 1407-1409 IN denotes of
T22455 1410-1413 NN denotes Apc
T22456 1414-1416 IN denotes in
T22457 1417-1421 RB denotes down
T22458 1422-1432 NN denotes regulation
T22459 1421-1422 HYPH denotes -
T22460 1433-1435 IN denotes of
T22461 1436-1437 NN denotes β
T22462 1438-1445 NN denotes catenin
T22463 1437-1438 HYPH denotes -
T22464 1445-1447 , denotes ,
T22465 1447-1451 NN denotes loss
T22466 1452-1454 IN denotes of
T22467 1455-1458 NNP denotes Apc
T22468 1459-1464 MD denotes would
T22469 1465-1475 RB denotes inevitably
T22470 1481-1483 IN denotes to
T22471 1484-1491 JJ denotes altered
T22472 1492-1502 NN denotes expression
T22473 1503-1505 IN denotes of
T22474 1506-1507 NN denotes β
T22475 1508-1515 NN denotes catenin
T22476 1507-1508 HYPH denotes -
T22477 1516-1518 IN denotes in
T22478 1519-1529 JJ denotes ectodermal
T22479 1530-1535 NNS denotes cells
T22480 1536-1542 IN denotes during
T22481 1543-1546 DT denotes the
T22482 1560-1569 NN denotes formation
T22483 1547-1551 NN denotes hair
T22484 1552-1559 NN denotes placode
T22485 1569-1571 , denotes ,
T22486 1571-1577 VBG denotes giving
T22487 1578-1582 NN denotes rise
T22488 1583-1585 IN denotes to
T22489 1586-1594 JJ denotes aberrant
T22490 1606-1612 NN denotes growth
T22491 1595-1605 JJ denotes follicular
T22492 1613-1623 IN denotes throughout
T22493 1624-1627 DT denotes the
T22494 1638-1647 NN denotes epidermis
T22495 1628-1637 JJ denotes embryonic
T22496 1647-1649 , denotes ,
T22497 1649-1658 VBG denotes including
T22498 1659-1662 DT denotes the
T22499 1663-1671 NNS denotes footpads
T22500 1671-1673 , denotes ,
T22501 1673-1678 WRB denotes where
T22502 1688-1696 JJ denotes hairless
T22503 1679-1687 RB denotes normally
T22504 1697-1698 -LRB- denotes (
T22505 1705-1707 NN denotes 5B
T22506 1698-1704 NN denotes Figure
T22507 1707-1709 , denotes ,
T22508 1709-1711 NN denotes 5D
T22509 1711-1713 , denotes ,
T22510 1713-1715 NN denotes 5F
T22511 1715-1717 , denotes ,
T22512 1717-1720 CC denotes and
T22513 1721-1723 NN denotes 5H
T22514 1723-1724 -RRB- denotes )
T22515 1724-1725 . denotes .
T22516 1725-1972 sentence denotes Of interest are the phenotypic similarities and differences between our KA mutant mice and the previously described K14-ΔN87βcat transgenic mice expressing stable β-catenin under the control of K14 promoter [25] and K14-Lef1 transgenic mice [27].
T22517 1726-1728 IN denotes Of
T22518 1738-1741 VBP denotes are
T22519 1729-1737 NN denotes interest
T22520 1742-1745 DT denotes the
T22521 1757-1769 NNS denotes similarities
T22522 1746-1756 JJ denotes phenotypic
T22523 1770-1773 CC denotes and
T22524 1774-1785 NNS denotes differences
T22525 1786-1793 IN denotes between
T22526 1794-1797 PRP$ denotes our
T22527 1808-1812 NNS denotes mice
T22528 1798-1800 NN denotes KA
T22529 1801-1807 JJ denotes mutant
T22530 1813-1816 CC denotes and
T22531 1817-1820 DT denotes the
T22532 1866-1870 NNS denotes mice
T22533 1821-1831 RB denotes previously
T22534 1832-1841 VBN denotes described
T22535 1842-1845 NN denotes K14
T22536 1846-1854 NN denotes ΔN87βcat
T22537 1845-1846 HYPH denotes -
T22538 1855-1865 JJ denotes transgenic
T22539 1871-1881 VBG denotes expressing
T22540 1882-1888 JJ denotes stable
T22541 1891-1898 NN denotes catenin
T22542 1889-1890 NN denotes β
T22543 1890-1891 HYPH denotes -
T22544 1899-1904 IN denotes under
T22545 1905-1908 DT denotes the
T22546 1909-1916 NN denotes control
T22547 1917-1919 IN denotes of
T22548 1920-1923 NN denotes K14
T22549 1924-1932 NN denotes promoter
T22550 1933-1934 -LRB- denotes [
T22551 1934-1936 CD denotes 25
T22552 1936-1937 -RRB- denotes ]
T22553 1938-1941 CC denotes and
T22554 1942-1945 NN denotes K14
T22555 1946-1950 NN denotes Lef1
T22556 1945-1946 HYPH denotes -
T22557 1962-1966 NNS denotes mice
T22558 1951-1961 JJ denotes transgenic
T22559 1967-1968 -LRB- denotes [
T22560 1968-1970 CD denotes 27
T22561 1970-1971 -RRB- denotes ]
T22562 1971-1972 . denotes .
T22563 1972-2089 sentence denotes Surprisingly, our mutant mice shared more similarities with the K14-Lef1 mice than the K14-ΔN87βcat transgenic mice.
T22564 1973-1985 RB denotes Surprisingly
T22565 2003-2009 VBD denotes shared
T22566 1985-1987 , denotes ,
T22567 1987-1990 PRP$ denotes our
T22568 1998-2002 NNS denotes mice
T22569 1991-1997 JJ denotes mutant
T22570 2010-2014 JJR denotes more
T22571 2015-2027 NNS denotes similarities
T22572 2028-2032 IN denotes with
T22573 2033-2036 DT denotes the
T22574 2046-2050 NNS denotes mice
T22575 2037-2040 NN denotes K14
T22576 2041-2045 NN denotes Lef1
T22577 2040-2041 HYPH denotes -
T22578 2051-2055 IN denotes than
T22579 2056-2059 DT denotes the
T22580 2084-2088 NNS denotes mice
T22581 2060-2063 NN denotes K14
T22582 2064-2072 NN denotes ΔN87βcat
T22583 2063-2064 HYPH denotes -
T22584 2073-2083 JJ denotes transgenic
T22585 2088-2089 . denotes .
T22586 2089-2230 sentence denotes For example, the KA mutant mice displayed the disoriented and short, curly whiskers seen in K14-Lef1but not in K14-ΔN87βcat transgenic mice.
T22587 2090-2093 IN denotes For
T22588 2122-2131 VBD denotes displayed
T22589 2094-2101 NN denotes example
T22590 2101-2103 , denotes ,
T22591 2103-2106 DT denotes the
T22592 2117-2121 NNS denotes mice
T22593 2107-2109 NN denotes KA
T22594 2110-2116 JJ denotes mutant
T22595 2132-2135 DT denotes the
T22596 2165-2173 NNS denotes whiskers
T22597 2136-2147 JJ denotes disoriented
T22598 2148-2151 CC denotes and
T22599 2152-2157 JJ denotes short
T22600 2157-2159 , denotes ,
T22601 2159-2164 JJ denotes curly
T22602 2174-2178 VBN denotes seen
T22603 2179-2181 IN denotes in
T22604 2182-2185 NN denotes K14
T22605 2186-2193 NN denotes Lef1but
T22606 2185-2186 HYPH denotes -
T22607 2194-2197 RB denotes not
T22608 2198-2200 IN denotes in
T22609 2201-2204 NN denotes K14
T22610 2205-2213 NN denotes ΔN87βcat
T22611 2204-2205 HYPH denotes -
T22612 2225-2229 NNS denotes mice
T22613 2214-2224 JJ denotes transgenic
T22614 2229-2230 . denotes .
T22615 2230-2516 sentence denotes In addition, KA mutant mice displayed a disorganized hair coat beginning with the emergence of neonatal hairs, similar to that observed in K14-Lef1 mice, whereas in K14-ΔN87βcat mice, embryonic hair follicle morphogenesis was unaffected and other skin changes only emerged postnatally.
T22616 2231-2233 IN denotes In
T22617 2259-2268 VBD denotes displayed
T22618 2234-2242 NN denotes addition
T22619 2242-2244 , denotes ,
T22620 2244-2246 NN denotes KA
T22621 2254-2258 NNS denotes mice
T22622 2247-2253 JJ denotes mutant
T22623 2269-2270 DT denotes a
T22624 2289-2293 NN denotes coat
T22625 2271-2283 JJ denotes disorganized
T22626 2284-2288 NN denotes hair
T22627 2294-2303 VBG denotes beginning
T22628 2304-2308 IN denotes with
T22629 2309-2312 DT denotes the
T22630 2313-2322 NN denotes emergence
T22631 2323-2325 IN denotes of
T22632 2326-2334 JJ denotes neonatal
T22633 2335-2340 NNS denotes hairs
T22634 2340-2342 , denotes ,
T22635 2342-2349 JJ denotes similar
T22636 2350-2352 IN denotes to
T22637 2353-2357 DT denotes that
T22638 2358-2366 VBN denotes observed
T22639 2367-2369 IN denotes in
T22640 2370-2373 NN denotes K14
T22641 2374-2378 NN denotes Lef1
T22642 2373-2374 HYPH denotes -
T22643 2379-2383 NNS denotes mice
T22644 2383-2385 , denotes ,
T22645 2385-2392 IN denotes whereas
T22646 2453-2456 VBD denotes was
T22647 2393-2395 IN denotes in
T22648 2396-2399 NN denotes K14
T22649 2400-2408 NN denotes ΔN87βcat
T22650 2399-2400 HYPH denotes -
T22651 2409-2413 NNS denotes mice
T22652 2413-2415 , denotes ,
T22653 2415-2424 JJ denotes embryonic
T22654 2439-2452 NN denotes morphogenesis
T22655 2425-2429 NN denotes hair
T22656 2430-2438 NN denotes follicle
T22657 2457-2467 JJ denotes unaffected
T22658 2468-2471 CC denotes and
T22659 2472-2477 JJ denotes other
T22660 2483-2490 NNS denotes changes
T22661 2478-2482 NN denotes skin
T22662 2496-2503 VBD denotes emerged
T22663 2491-2495 RB denotes only
T22664 2504-2515 RB denotes postnatally
T22665 2515-2516 . denotes .
T22666 2516-2621 sentence denotes The reason for this difference could be attributed to one or all of three possible contributing factors.
T22667 2517-2520 DT denotes The
T22668 2521-2527 NN denotes reason
T22669 2557-2567 VBN denotes attributed
T22670 2528-2531 IN denotes for
T22671 2532-2536 DT denotes this
T22672 2537-2547 NN denotes difference
T22673 2548-2553 MD denotes could
T22674 2554-2556 VB denotes be
T22675 2568-2570 IN denotes to
T22676 2571-2574 CD denotes one
T22677 2575-2577 CC denotes or
T22678 2578-2581 DT denotes all
T22679 2582-2584 IN denotes of
T22680 2585-2590 CD denotes three
T22681 2613-2620 NNS denotes factors
T22682 2591-2599 JJ denotes possible
T22683 2600-2612 VBG denotes contributing
T22684 2620-2621 . denotes .
T22685 2621-2848 sentence denotes (1) Although the K14 promoter itself is known to initiate the expression at E9.5 and elevated dramatically by E13.5–E14.5 [19,31], many factors could influence the expression of promoter/transgene construct in transgenic mice.
T22686 2622-2623 -LRB- denotes (
T22687 2623-2624 LS denotes 1
T22688 2772-2781 VB denotes influence
T22689 2624-2625 -RRB- denotes )
T22690 2626-2634 IN denotes Although
T22691 2662-2667 VBN denotes known
T22692 2635-2638 DT denotes the
T22693 2643-2651 NN denotes promoter
T22694 2639-2642 NN denotes K14
T22695 2652-2658 PRP denotes itself
T22696 2659-2661 VBZ denotes is
T22697 2668-2670 TO denotes to
T22698 2671-2679 VB denotes initiate
T22699 2680-2683 DT denotes the
T22700 2684-2694 NN denotes expression
T22701 2695-2697 IN denotes at
T22702 2698-2702 NN denotes E9.5
T22703 2703-2706 CC denotes and
T22704 2707-2715 VBN denotes elevated
T22705 2716-2728 RB denotes dramatically
T22706 2729-2731 IN denotes by
T22707 2732-2737 NN denotes E13.5
T22708 2737-2738 SYM denotes –
T22709 2738-2743 NN denotes E14.5
T22710 2744-2745 -LRB- denotes [
T22711 2748-2750 CD denotes 31
T22712 2745-2747 CD denotes 19
T22713 2747-2748 , denotes ,
T22714 2750-2751 -RRB- denotes ]
T22715 2751-2753 , denotes ,
T22716 2753-2757 JJ denotes many
T22717 2758-2765 NNS denotes factors
T22718 2766-2771 MD denotes could
T22719 2782-2785 DT denotes the
T22720 2786-2796 NN denotes expression
T22721 2797-2799 IN denotes of
T22722 2800-2808 NN denotes promoter
T22723 2809-2818 NN denotes transgene
T22724 2808-2809 HYPH denotes /
T22725 2819-2828 NN denotes construct
T22726 2829-2831 IN denotes in
T22727 2832-2842 JJ denotes transgenic
T22728 2843-2847 NNS denotes mice
T22729 2847-2848 . denotes .
T22730 2848-2963 sentence denotes One of the most important considerations has to do with the integration site of the transgene in the mouse genome.
T22731 2849-2852 CD denotes One
T22732 2890-2893 VBZ denotes has
T22733 2853-2855 IN denotes of
T22734 2856-2859 DT denotes the
T22735 2875-2889 NNS denotes considerations
T22736 2860-2864 RBS denotes most
T22737 2865-2874 JJ denotes important
T22738 2894-2896 TO denotes to
T22739 2897-2899 VB denotes do
T22740 2900-2904 IN denotes with
T22741 2905-2908 DT denotes the
T22742 2921-2925 NN denotes site
T22743 2909-2920 NN denotes integration
T22744 2926-2928 IN denotes of
T22745 2929-2932 DT denotes the
T22746 2933-2942 NN denotes transgene
T22747 2943-2945 IN denotes in
T22748 2946-2949 DT denotes the
T22749 2956-2962 NN denotes genome
T22750 2950-2955 NN denotes mouse
T22751 2962-2963 . denotes .
T22752 2963-3086 sentence denotes Depending on the location of integration, the transcriptional activity of even the same transgene could vary considerably.
T22753 2964-2973 VBG denotes Depending
T22754 3068-3072 VB denotes vary
T22755 2974-2976 IN denotes on
T22756 2977-2980 DT denotes the
T22757 2981-2989 NN denotes location
T22758 2990-2992 IN denotes of
T22759 2993-3004 NN denotes integration
T22760 3004-3006 , denotes ,
T22761 3006-3009 DT denotes the
T22762 3026-3034 NN denotes activity
T22763 3010-3025 JJ denotes transcriptional
T22764 3035-3037 IN denotes of
T22765 3038-3042 RB denotes even
T22766 3052-3061 NN denotes transgene
T22767 3043-3046 DT denotes the
T22768 3047-3051 JJ denotes same
T22769 3062-3067 MD denotes could
T22770 3073-3085 RB denotes considerably
T22771 3085-3086 . denotes .
T22772 3086-3275 sentence denotes It is possible that the apparent lack of ΔN87βcat function in embryogenesis could be due to the delayed or weak expression of the K14-ΔN87βcat transgene compared to the intrinsic promoter.
T22773 3087-3089 PRP denotes It
T22774 3090-3092 VBZ denotes is
T22775 3093-3101 JJ denotes possible
T22776 3102-3106 IN denotes that
T22777 3169-3171 VB denotes be
T22778 3107-3110 DT denotes the
T22779 3120-3124 NN denotes lack
T22780 3111-3119 JJ denotes apparent
T22781 3125-3127 IN denotes of
T22782 3128-3136 NN denotes ΔN87βcat
T22783 3137-3145 NN denotes function
T22784 3146-3148 IN denotes in
T22785 3149-3162 NN denotes embryogenesis
T22786 3163-3168 MD denotes could
T22787 3172-3175 IN denotes due
T22788 3176-3178 IN denotes to
T22789 3179-3182 DT denotes the
T22790 3199-3209 NN denotes expression
T22791 3183-3190 VBN denotes delayed
T22792 3191-3193 CC denotes or
T22793 3194-3198 JJ denotes weak
T22794 3210-3212 IN denotes of
T22795 3213-3216 DT denotes the
T22796 3230-3239 NN denotes transgene
T22797 3217-3220 NN denotes K14
T22798 3221-3229 NN denotes ΔN87βcat
T22799 3220-3221 HYPH denotes -
T22800 3240-3248 VBN denotes compared
T22801 3249-3251 IN denotes to
T22802 3252-3255 DT denotes the
T22803 3266-3274 NN denotes promoter
T22804 3256-3265 JJ denotes intrinsic
T22805 3274-3275 . denotes .
T22806 3275-3531 sentence denotes In contrast, Cre-mediated recombination is seen in E13.5 skin of K14-cre transgenic mice used in this study [16] and K14-cre–mediated truncation of the Apc gene is likely to have occurred by then, in time for the second wave of hair follicle morphgenesis.
T22807 3276-3278 IN denotes In
T22808 3319-3323 VBN denotes seen
T22809 3279-3287 NN denotes contrast
T22810 3287-3289 , denotes ,
T22811 3289-3292 NN denotes Cre
T22812 3293-3301 JJ denotes mediated
T22813 3292-3293 HYPH denotes -
T22814 3302-3315 NN denotes recombination
T22815 3316-3318 VBZ denotes is
T22816 3324-3326 IN denotes in
T22817 3327-3332 NN denotes E13.5
T22818 3333-3337 NN denotes skin
T22819 3338-3340 IN denotes of
T22820 3341-3344 NN denotes K14
T22821 3345-3348 NN denotes cre
T22822 3344-3345 HYPH denotes -
T22823 3360-3364 NNS denotes mice
T22824 3349-3359 JJ denotes transgenic
T22825 3365-3369 VBN denotes used
T22826 3370-3372 IN denotes in
T22827 3373-3377 DT denotes this
T22828 3378-3383 NN denotes study
T22829 3384-3385 -LRB- denotes [
T22830 3385-3387 CD denotes 16
T22831 3387-3388 -RRB- denotes ]
T22832 3389-3392 CC denotes and
T22833 3393-3396 NN denotes K14
T22834 3397-3400 NN denotes cre
T22835 3396-3397 HYPH denotes -
T22836 3401-3409 JJ denotes mediated
T22837 3400-3401 HYPH denotes –
T22838 3410-3420 NN denotes truncation
T22839 3437-3439 VBZ denotes is
T22840 3421-3423 IN denotes of
T22841 3424-3427 DT denotes the
T22842 3432-3436 NN denotes gene
T22843 3428-3431 NN denotes Apc
T22844 3440-3446 JJ denotes likely
T22845 3447-3449 TO denotes to
T22846 3455-3463 VBN denotes occurred
T22847 3450-3454 VB denotes have
T22848 3464-3466 IN denotes by
T22849 3467-3471 RB denotes then
T22850 3471-3473 , denotes ,
T22851 3473-3475 IN denotes in
T22852 3476-3480 NN denotes time
T22853 3481-3484 IN denotes for
T22854 3485-3488 DT denotes the
T22855 3496-3500 NN denotes wave
T22856 3489-3495 JJ denotes second
T22857 3501-3503 IN denotes of
T22858 3504-3508 NN denotes hair
T22859 3509-3517 NN denotes follicle
T22860 3518-3530 NN denotes morphgenesis
T22861 3530-3531 . denotes .
T22862 3531-3750 sentence denotes (2) Another important fact is that in the aforementioned transgenic model the overexpression of transgene is confined to the basal cells of the epidermis and the ORS of hair follicles, where the K14 promoter is active.
T22863 3532-3533 -LRB- denotes (
T22864 3533-3534 LS denotes 2
T22865 3559-3561 VBZ denotes is
T22866 3534-3535 -RRB- denotes )
T22867 3536-3543 DT denotes Another
T22868 3554-3558 NN denotes fact
T22869 3544-3553 JJ denotes important
T22870 3562-3566 IN denotes that
T22871 3641-3649 VBN denotes confined
T22872 3567-3569 IN denotes in
T22873 3570-3573 DT denotes the
T22874 3600-3605 NN denotes model
T22875 3574-3588 JJ denotes aforementioned
T22876 3589-3599 JJ denotes transgenic
T22877 3606-3609 DT denotes the
T22878 3610-3624 NN denotes overexpression
T22879 3625-3627 IN denotes of
T22880 3628-3637 NN denotes transgene
T22881 3638-3640 VBZ denotes is
T22882 3650-3652 IN denotes to
T22883 3653-3656 DT denotes the
T22884 3663-3668 NNS denotes cells
T22885 3657-3662 JJ denotes basal
T22886 3669-3671 IN denotes of
T22887 3672-3675 DT denotes the
T22888 3676-3685 NN denotes epidermis
T22889 3686-3689 CC denotes and
T22890 3690-3693 DT denotes the
T22891 3694-3697 NN denotes ORS
T22892 3698-3700 IN denotes of
T22893 3701-3705 NN denotes hair
T22894 3706-3715 NNS denotes follicles
T22895 3715-3717 , denotes ,
T22896 3717-3722 WRB denotes where
T22897 3740-3742 VBZ denotes is
T22898 3723-3726 DT denotes the
T22899 3731-3739 NN denotes promoter
T22900 3727-3730 NN denotes K14
T22901 3743-3749 JJ denotes active
T22902 3749-3750 . denotes .
T22903 3750-3859 sentence denotes The expression of transgene is hence transient and stops once K14-expressing cells terminally differentiate.
T22904 3751-3754 DT denotes The
T22905 3755-3765 NN denotes expression
T22906 3779-3781 VBZ denotes is
T22907 3766-3768 IN denotes of
T22908 3769-3778 NN denotes transgene
T22909 3782-3787 RB denotes hence
T22910 3788-3797 JJ denotes transient
T22911 3798-3801 CC denotes and
T22912 3802-3807 VBZ denotes stops
T22913 3808-3812 IN denotes once
T22914 3845-3858 VBP denotes differentiate
T22915 3813-3816 NN denotes K14
T22916 3817-3827 VBG denotes expressing
T22917 3816-3817 HYPH denotes -
T22918 3828-3833 NNS denotes cells
T22919 3834-3844 RB denotes terminally
T22920 3858-3859 . denotes .
T22921 3859-4075 sentence denotes In contrast, in our model, K14-cre–mediated deletion of Apc would result in Apc mutation not only in K14 promoter active cells, but remain so in all cell layers that derived from the K14 promoter active progenitors.
T22922 3860-3862 IN denotes In
T22923 3926-3932 VB denotes result
T22924 3863-3871 NN denotes contrast
T22925 3871-3873 , denotes ,
T22926 3873-3875 IN denotes in
T22927 3876-3879 PRP$ denotes our
T22928 3880-3885 NN denotes model
T22929 3885-3887 , denotes ,
T22930 3887-3890 NN denotes K14
T22931 3891-3894 NN denotes cre
T22932 3890-3891 HYPH denotes -
T22933 3895-3903 JJ denotes mediated
T22934 3894-3895 HYPH denotes –
T22935 3904-3912 NN denotes deletion
T22936 3913-3915 IN denotes of
T22937 3916-3919 NN denotes Apc
T22938 3920-3925 MD denotes would
T22939 3933-3935 IN denotes in
T22940 3936-3939 NN denotes Apc
T22941 3940-3948 NN denotes mutation
T22942 3949-3952 RB denotes not
T22943 3958-3960 IN denotes in
T22944 3953-3957 RB denotes only
T22945 3961-3964 NN denotes K14
T22946 3981-3986 NNS denotes cells
T22947 3965-3973 NN denotes promoter
T22948 3974-3980 JJ denotes active
T22949 3986-3988 , denotes ,
T22950 3988-3991 CC denotes but
T22951 3992-3998 VBP denotes remain
T22952 3999-4001 RB denotes so
T22953 4002-4004 IN denotes in
T22954 4005-4008 DT denotes all
T22955 4014-4020 NNS denotes layers
T22956 4009-4013 NN denotes cell
T22957 4021-4025 WDT denotes that
T22958 4026-4033 VBN denotes derived
T22959 4034-4038 IN denotes from
T22960 4039-4042 DT denotes the
T22961 4063-4074 NNS denotes progenitors
T22962 4043-4046 NN denotes K14
T22963 4047-4055 NN denotes promoter
T22964 4056-4062 JJ denotes active
T22965 4074-4075 . denotes .
T22966 4075-4174 sentence denotes These derivatives include the suprabasal epidermis and the entire epithelium of the hair follicle.
T22967 4076-4081 DT denotes These
T22968 4082-4093 NNS denotes derivatives
T22969 4094-4101 VBP denotes include
T22970 4102-4105 DT denotes the
T22971 4117-4126 NN denotes epidermis
T22972 4106-4116 JJ denotes suprabasal
T22973 4127-4130 CC denotes and
T22974 4131-4134 DT denotes the
T22975 4142-4152 NN denotes epithelium
T22976 4135-4141 JJ denotes entire
T22977 4153-4155 IN denotes of
T22978 4156-4159 DT denotes the
T22979 4165-4173 NN denotes follicle
T22980 4160-4164 NN denotes hair
T22981 4173-4174 . denotes .
T22982 4174-4288 sentence denotes Stabilization of β-catenin in a broader population of cells could account for some of the phenotypic differences.
T22983 4175-4188 NN denotes Stabilization
T22984 4241-4248 VB denotes account
T22985 4189-4191 IN denotes of
T22986 4192-4193 NN denotes β
T22987 4194-4201 NN denotes catenin
T22988 4193-4194 HYPH denotes -
T22989 4202-4204 IN denotes in
T22990 4205-4206 DT denotes a
T22991 4215-4225 NN denotes population
T22992 4207-4214 JJR denotes broader
T22993 4226-4228 IN denotes of
T22994 4229-4234 NNS denotes cells
T22995 4235-4240 MD denotes could
T22996 4249-4252 IN denotes for
T22997 4253-4257 DT denotes some
T22998 4258-4260 IN denotes of
T22999 4261-4264 DT denotes the
T23000 4276-4287 NNS denotes differences
T23001 4265-4275 JJ denotes phenotypic
T23002 4287-4288 . denotes .
T23003 4288-4425 sentence denotes However, we did not detect any elevated β-catenin expression in either K1- or K6-positive differentiated cells in postnatal mutant skin.
T23004 4289-4296 RB denotes However
T23005 4309-4315 VB denotes detect
T23006 4296-4298 , denotes ,
T23007 4298-4300 PRP denotes we
T23008 4301-4304 VBD denotes did
T23009 4305-4308 RB denotes not
T23010 4316-4319 DT denotes any
T23011 4339-4349 NN denotes expression
T23012 4320-4328 JJ denotes elevated
T23013 4329-4330 NN denotes β
T23014 4331-4338 NN denotes catenin
T23015 4330-4331 HYPH denotes -
T23016 4350-4352 IN denotes in
T23017 4353-4359 CC denotes either
T23018 4394-4399 NNS denotes cells
T23019 4360-4362 NN denotes K1
T23020 4370-4378 JJ denotes positive
T23021 4362-4363 HYPH denotes -
T23022 4364-4366 CC denotes or
T23023 4367-4369 NN denotes K6
T23024 4369-4370 HYPH denotes -
T23025 4379-4393 VBN denotes differentiated
T23026 4400-4402 IN denotes in
T23027 4403-4412 JJ denotes postnatal
T23028 4420-4424 NN denotes skin
T23029 4413-4419 JJ denotes mutant
T23030 4424-4425 . denotes .
T23031 4425-4665 sentence denotes This indicates that despite the absence of Apc and potential stabilization of β-catenin in derivatives of K14-expressing progenitors, elevated β-catenin expression, and subsequent cell fate determination may only take place in basal cells.
T23032 4426-4430 DT denotes This
T23033 4431-4440 VBZ denotes indicates
T23034 4441-4445 IN denotes that
T23035 4639-4643 VB denotes take
T23036 4446-4453 IN denotes despite
T23037 4454-4457 DT denotes the
T23038 4458-4465 NN denotes absence
T23039 4466-4468 IN denotes of
T23040 4469-4472 NN denotes Apc
T23041 4473-4476 CC denotes and
T23042 4477-4486 JJ denotes potential
T23043 4487-4500 NN denotes stabilization
T23044 4501-4503 IN denotes of
T23045 4504-4505 NN denotes β
T23046 4506-4513 NN denotes catenin
T23047 4505-4506 HYPH denotes -
T23048 4514-4516 IN denotes in
T23049 4517-4528 NNS denotes derivatives
T23050 4529-4531 IN denotes of
T23051 4532-4535 NN denotes K14
T23052 4536-4546 VBG denotes expressing
T23053 4535-4536 HYPH denotes -
T23054 4547-4558 NNS denotes progenitors
T23055 4558-4560 , denotes ,
T23056 4560-4568 JJ denotes elevated
T23057 4579-4589 NN denotes expression
T23058 4569-4570 NN denotes β
T23059 4571-4578 NN denotes catenin
T23060 4570-4571 HYPH denotes -
T23061 4589-4591 , denotes ,
T23062 4591-4594 CC denotes and
T23063 4595-4605 JJ denotes subsequent
T23064 4616-4629 NN denotes determination
T23065 4606-4610 NN denotes cell
T23066 4611-4615 NN denotes fate
T23067 4630-4633 MD denotes may
T23068 4634-4638 RB denotes only
T23069 4644-4649 NN denotes place
T23070 4650-4652 IN denotes in
T23071 4653-4658 JJ denotes basal
T23072 4659-4664 NNS denotes cells
T23073 4664-4665 . denotes .
T23074 4665-4880 sentence denotes (3) We cannot exclude the possibility that given the multifunctional properties of Apc, disruption of its functions other than down-regulation of β-catenin may also have contributed to the observed overt phenotype.
T23075 4666-4667 -LRB- denotes (
T23076 4667-4668 LS denotes 3
T23077 4680-4687 VB denotes exclude
T23078 4668-4669 -RRB- denotes )
T23079 4670-4672 PRP denotes We
T23080 4673-4676 MD denotes can
T23081 4676-4679 RB denotes not
T23082 4688-4691 DT denotes the
T23083 4692-4703 NN denotes possibility
T23084 4704-4708 IN denotes that
T23085 4836-4847 VBN denotes contributed
T23086 4709-4714 VBN denotes given
T23087 4715-4718 DT denotes the
T23088 4735-4745 NNS denotes properties
T23089 4719-4734 JJ denotes multifunctional
T23090 4746-4748 IN denotes of
T23091 4749-4752 NN denotes Apc
T23092 4752-4754 , denotes ,
T23093 4754-4764 NN denotes disruption
T23094 4765-4767 IN denotes of
T23095 4768-4771 PRP$ denotes its
T23096 4772-4781 NNS denotes functions
T23097 4782-4787 JJ denotes other
T23098 4788-4792 IN denotes than
T23099 4793-4797 RB denotes down
T23100 4798-4808 NN denotes regulation
T23101 4797-4798 HYPH denotes -
T23102 4809-4811 IN denotes of
T23103 4812-4813 NN denotes β
T23104 4814-4821 NN denotes catenin
T23105 4813-4814 HYPH denotes -
T23106 4822-4825 MD denotes may
T23107 4826-4830 RB denotes also
T23108 4831-4835 VB denotes have
T23109 4848-4850 IN denotes to
T23110 4851-4854 DT denotes the
T23111 4870-4879 NN denotes phenotype
T23112 4855-4863 VBN denotes observed
T23113 4864-4869 JJ denotes overt
T23114 4879-4880 . denotes .
R5958 T22189 T22190 amod Current,models
R5959 T22190 T22191 nsubj models,suggest
R5960 T22192 T22190 prep of,models
R5961 T22193 T22194 compound hair,follicle
R5962 T22194 T22195 compound follicle,development
R5963 T22195 T22192 pobj development,of
R5964 T22196 T22197 mark that,achieved
R5965 T22197 T22191 ccomp achieved,suggest
R5966 T22198 T22199 det the,establishment
R5967 T22199 T22197 nsubjpass establishment,achieved
R5968 T22200 T22199 prep of,establishment
R5969 T22201 T22202 det a,array
R5970 T22202 T22200 pobj array,of
R5971 T22203 T22202 amod regular,array
R5972 T22204 T22202 prep of,array
R5973 T22205 T22204 pobj placodes,of
R5974 T22206 T22202 prep in,array
R5975 T22207 T22208 det the,epithelium
R5976 T22208 T22206 pobj epithelium,in
R5977 T22209 T22208 compound surface,epithelium
R5978 T22210 T22199 prep in,establishment
R5979 T22211 T22210 pobj response,in
R5980 T22212 T22211 prep to,response
R5981 T22213 T22214 det the,message
R5982 T22214 T22212 pobj message,to
R5983 T22215 T22214 amod first,message
R5984 T22216 T22214 amod dermal,message
R5985 T22217 T22197 auxpass is,achieved
R5986 T22218 T22197 prep through,achieved
R5987 T22219 T22220 det the,activities
R5988 T22220 T22218 pobj activities,through
R5989 T22221 T22220 amod competing,activities
R5990 T22222 T22220 prep of,activities
R5991 T22223 T22222 pobj molecules,of
R5992 T22224 T22225 dep that,promote
R5993 T22225 T22223 relcl promote,molecules
R5994 T22226 T22225 cc or,promote
R5995 T22227 T22225 conj repress,promote
R5996 T22228 T22229 compound placode,fate
R5997 T22229 T22227 dobj fate,repress
R5998 T22230 T22231 punct [,24
R5999 T22231 T22191 parataxis 24,suggest
R6000 T22232 T22231 punct ],24
R6001 T22233 T22191 punct .,suggest
R6002 T22235 T22236 expl There,is
R6003 T22237 T22238 amod accumulating,evidence
R6004 T22238 T22236 attr evidence,is
R6005 T22239 T22240 mark that,involved
R6006 T22240 T22238 acl involved,evidence
R6007 T22241 T22240 nsubjpass activation,involved
R6008 T22242 T22241 prep of,activation
R6009 T22243 T22244 det the,pathway
R6010 T22244 T22242 pobj pathway,of
R6011 T22245 T22244 compound Wnt,pathway
R6012 T22246 T22244 compound signaling,pathway
R6013 T22247 T22241 prep in,activation
R6014 T22248 T22249 det the,dermis
R6015 T22249 T22247 pobj dermis,in
R6016 T22250 T22240 aux may,involved
R6017 T22251 T22240 auxpass be,involved
R6018 T22252 T22240 prep in,involved
R6019 T22253 T22252 pcomp establishing,in
R6020 T22254 T22255 det the,signal
R6021 T22255 T22253 dobj signal,establishing
R6022 T22256 T22255 amod first,signal
R6023 T22257 T22255 amod dermal,signal
R6024 T22258 T22236 punct .,is
R6025 T22260 T22261 amod Experimental,activation
R6026 T22261 T22262 nsubj activation,induces
R6027 T22263 T22261 prep of,activation
R6028 T22264 T22265 amod epithelial,signaling
R6029 T22265 T22263 pobj signaling,of
R6030 T22266 T22267 compound β,catenin
R6031 T22267 T22265 compound catenin,signaling
R6032 T22268 T22267 punct -,catenin
R6033 T22269 T22261 punct (,activation
R6034 T22270 T22261 prep by,activation
R6035 T22271 T22270 pobj expression,by
R6036 T22272 T22271 prep of,expression
R6037 T22273 T22274 compound N,terminal
R6038 T22274 T22276 npadvmod terminal,truncated
R6039 T22275 T22274 punct -,terminal
R6040 T22276 T22278 amod truncated,forms
R6041 T22277 T22276 punct –,truncated
R6042 T22278 T22272 pobj forms,of
R6043 T22279 T22278 punct ", ",forms
R6044 T22280 T22281 advmod constitutively,stabilized
R6045 T22281 T22278 amod stabilized,forms
R6046 T22282 T22278 prep of,forms
R6047 T22283 T22284 compound β,catenin
R6048 T22284 T22282 pobj catenin,of
R6049 T22285 T22284 punct -,catenin
R6050 T22286 T22271 cc or,expression
R6051 T22287 T22288 amod ectopic,expression
R6052 T22288 T22271 conj expression,expression
R6053 T22289 T22288 prep of,expression
R6054 T22290 T22289 pobj Lef1,of
R6055 T22291 T22262 punct ),induces
R6056 T22292 T22293 amod ectopic,follicles
R6057 T22293 T22262 dobj follicles,induces
R6058 T22294 T22262 prep in,induces
R6059 T22295 T22296 preconj both,mouse
R6060 T22296 T22297 nmod mouse,skin
R6061 T22297 T22294 pobj skin,in
R6062 T22298 T22296 cc and,mouse
R6063 T22299 T22296 conj chick,mouse
R6064 T22300 T22301 punct [,25
R6065 T22301 T22262 parataxis 25,induces
R6066 T22302 T22303 punct –,27
R6067 T22303 T22301 prep 27,25
R6068 T22304 T22301 punct ],25
R6069 T22305 T22262 punct .,induces
R6070 T22307 T22308 advmod Conversely,results
R6071 T22309 T22308 punct ", ",results
R6072 T22310 T22311 amod down,regulation
R6073 T22311 T22308 nsubj regulation,results
R6074 T22312 T22311 punct -,regulation
R6075 T22313 T22311 prep of,regulation
R6076 T22314 T22315 compound β,catenin
R6077 T22315 T22317 compound catenin,signaling
R6078 T22316 T22315 punct -,catenin
R6079 T22317 T22313 pobj signaling,of
R6080 T22318 T22311 punct (,regulation
R6081 T22319 T22311 prep through,regulation
R6082 T22320 T22321 npadvmod Lef1,knock
R6083 T22321 T22322 amod knock,expression
R6084 T22322 T22319 pobj expression,through
R6085 T22323 T22321 punct -,knock
R6086 T22324 T22321 prt out,knock
R6087 T22325 T22322 punct ", ",expression
R6088 T22326 T22322 amod ectopic,expression
R6089 T22327 T22322 prep of,expression
R6090 T22328 T22329 compound Wnt,inhibitor
R6091 T22329 T22327 pobj inhibitor,of
R6092 T22330 T22329 appos Dkk1,inhibitor
R6093 T22331 T22322 cc or,expression
R6094 T22332 T22333 amod conditional,deletion
R6095 T22333 T22322 conj deletion,expression
R6096 T22334 T22333 prep of,deletion
R6097 T22335 T22336 compound β,catenin
R6098 T22336 T22334 pobj catenin,of
R6099 T22337 T22336 punct -,catenin
R6100 T22338 T22333 prep in,deletion
R6101 T22339 T22338 pobj epidermis,in
R6102 T22340 T22308 punct ),results
R6103 T22341 T22308 prep in,results
R6104 T22342 T22341 pobj loss,in
R6105 T22343 T22342 prep of,loss
R6106 T22344 T22343 pobj vibrissae,of
R6107 T22345 T22344 cc and,vibrissae
R6108 T22346 T22347 det some,follicles
R6109 T22347 T22344 conj follicles,vibrissae
R6110 T22348 T22347 compound pelage,follicles
R6111 T22349 T22308 prep in,results
R6112 T22350 T22349 pobj mice,in
R6113 T22351 T22352 punct [,28
R6114 T22352 T22308 parataxis 28,results
R6115 T22353 T22354 punct –,30
R6116 T22354 T22352 prep 30,28
R6117 T22355 T22352 punct ],28
R6118 T22356 T22308 punct .,results
R6119 T22358 T22359 poss Our,finding
R6120 T22359 T22360 nsubj finding,is
R6121 T22361 T22362 mark that,resulted
R6122 T22362 T22359 acl resulted,finding
R6123 T22363 T22364 npadvmod K14,driven
R6124 T22364 T22366 amod driven,loss
R6125 T22365 T22364 punct -,driven
R6126 T22366 T22362 nsubj loss,resulted
R6127 T22367 T22366 compound Apc,loss
R6128 T22368 T22366 prep in,loss
R6129 T22369 T22370 amod embryonic,ectoderm
R6130 T22370 T22368 pobj ectoderm,in
R6131 T22371 T22362 prep in,resulted
R6132 T22372 T22373 advmod irregularly,spaced
R6133 T22373 T22374 amod spaced,initiation
R6134 T22374 T22371 pobj initiation,in
R6135 T22375 T22373 cc and,spaced
R6136 T22376 T22377 advmod often,clustered
R6137 T22377 T22373 conj clustered,spaced
R6138 T22378 T22377 advmod tightly,clustered
R6139 T22379 T22374 amod abnormal,initiation
R6140 T22380 T22374 compound hair,initiation
R6141 T22381 T22374 compound placode,initiation
R6142 T22382 T22374 cc and,initiation
R6143 T22383 T22384 compound follicle,morphogenesis
R6144 T22384 T22374 conj morphogenesis,initiation
R6145 T22385 T22386 punct (,4F
R6146 T22386 T22374 parataxis 4F,initiation
R6147 T22387 T22386 compound Figures,4F
R6148 T22388 T22386 punct ", ",4F
R6149 T22389 T22386 conj 5B,4F
R6150 T22390 T22389 punct ", ",5B
R6151 T22391 T22389 conj 5D,5B
R6152 T22392 T22391 punct ", ",5D
R6153 T22393 T22391 cc and,5D
R6154 T22394 T22391 conj 5F,5D
R6155 T22395 T22386 punct ),4F
R6156 T22396 T22397 advmod as,as
R6157 T22397 T22371 cc as,in
R6158 T22398 T22397 advmod well,as
R6159 T22399 T22371 conj in,in
R6160 T22400 T22401 det the,development
R6161 T22401 T22399 pobj development,in
R6162 T22402 T22401 prep of,development
R6163 T22403 T22404 amod multiple,buds
R6164 T22404 T22402 pobj buds,of
R6165 T22405 T22404 compound tooth,buds
R6166 T22406 T22407 punct (,4O
R6167 T22407 T22404 parataxis 4O,buds
R6168 T22408 T22407 compound Figure,4O
R6169 T22409 T22407 cc and,4O
R6170 T22410 T22407 conj 4P,4O
R6171 T22411 T22407 punct ),4O
R6172 T22412 T22360 punct ", ",is
R6173 T22413 T22360 prep in,is
R6174 T22414 T22413 pobj line,in
R6175 T22415 T22414 prep with,line
R6176 T22416 T22417 det the,effects
R6177 T22417 T22415 pobj effects,with
R6178 T22418 T22417 acl seen,effects
R6179 T22419 T22418 prep in,seen
R6180 T22420 T22419 pobj activation,in
R6181 T22421 T22420 prep of,activation
R6182 T22422 T22423 amod epithelial,signaling
R6183 T22423 T22421 pobj signaling,of
R6184 T22424 T22425 compound β,catenin
R6185 T22425 T22423 compound catenin,signaling
R6186 T22426 T22425 punct -,catenin
R6187 T22427 T22420 prep during,activation
R6188 T22428 T22429 compound placode,formation
R6189 T22429 T22427 pobj formation,during
R6190 T22430 T22360 punct ", ",is
R6191 T22431 T22360 advcl indicating,is
R6192 T22432 T22433 det the,role
R6193 T22433 T22431 dobj role,indicating
R6194 T22434 T22433 prep of,role
R6195 T22435 T22434 pobj Apc,of
R6196 T22436 T22433 prep in,role
R6197 T22437 T22436 pobj specification,in
R6198 T22438 T22437 prep of,specification
R6199 T22439 T22440 amod embryonic,cells
R6200 T22440 T22438 pobj cells,of
R6201 T22441 T22440 amod ectodermal,cells
R6202 T22442 T22440 compound stem,cells
R6203 T22443 T22444 aux to,produce
R6204 T22444 T22437 acl produce,specification
R6205 T22445 T22446 det a,follicle
R6206 T22446 T22444 dobj follicle,produce
R6207 T22447 T22446 compound hair,follicle
R6208 T22448 T22360 punct .,is
R6209 T22450 T22451 prep Given,lead
R6210 T22452 T22453 det the,role
R6211 T22453 T22450 pobj role,Given
R6212 T22454 T22453 prep of,role
R6213 T22455 T22454 pobj Apc,of
R6214 T22456 T22453 prep in,role
R6215 T22457 T22458 advmod down,regulation
R6216 T22458 T22456 pobj regulation,in
R6217 T22459 T22458 punct -,regulation
R6218 T22460 T22458 prep of,regulation
R6219 T22461 T22462 compound β,catenin
R6220 T22462 T22460 pobj catenin,of
R6221 T22463 T22462 punct -,catenin
R6222 T22464 T22451 punct ", ",lead
R6223 T22465 T22451 nsubj loss,lead
R6224 T22466 T22465 prep of,loss
R6225 T22467 T22466 pobj Apc,of
R6226 T22468 T22451 aux would,lead
R6227 T22469 T22451 advmod inevitably,lead
R6228 T22470 T22451 prep to,lead
R6229 T22471 T22472 amod altered,expression
R6230 T22472 T22470 pobj expression,to
R6231 T22473 T22472 prep of,expression
R6232 T22474 T22475 compound β,catenin
R6233 T22475 T22473 pobj catenin,of
R6234 T22476 T22475 punct -,catenin
R6235 T22477 T22451 prep in,lead
R6236 T22478 T22479 amod ectodermal,cells
R6237 T22479 T22477 pobj cells,in
R6238 T22480 T22451 prep during,lead
R6239 T22481 T22482 det the,formation
R6240 T22482 T22480 pobj formation,during
R6241 T22483 T22484 compound hair,placode
R6242 T22484 T22482 compound placode,formation
R6243 T22485 T22451 punct ", ",lead
R6244 T22486 T22451 advcl giving,lead
R6245 T22487 T22486 dobj rise,giving
R6246 T22488 T22486 prep to,giving
R6247 T22489 T22490 amod aberrant,growth
R6248 T22490 T22488 pobj growth,to
R6249 T22491 T22490 amod follicular,growth
R6250 T22492 T22486 prep throughout,giving
R6251 T22493 T22494 det the,epidermis
R6252 T22494 T22492 pobj epidermis,throughout
R6253 T22495 T22494 amod embryonic,epidermis
R6254 T22496 T22494 punct ", ",epidermis
R6255 T22497 T22494 prep including,epidermis
R6256 T22498 T22499 det the,footpads
R6257 T22499 T22497 pobj footpads,including
R6258 T22500 T22499 punct ", ",footpads
R6259 T22501 T22502 advmod where,hairless
R6260 T22502 T22499 relcl hairless,footpads
R6261 T22503 T22502 advmod normally,hairless
R6262 T22504 T22505 punct (,5B
R6263 T22505 T22451 parataxis 5B,lead
R6264 T22506 T22505 compound Figure,5B
R6265 T22507 T22505 punct ", ",5B
R6266 T22508 T22505 conj 5D,5B
R6267 T22509 T22508 punct ", ",5D
R6268 T22510 T22508 conj 5F,5D
R6269 T22511 T22510 punct ", ",5F
R6270 T22512 T22510 cc and,5F
R6271 T22513 T22510 conj 5H,5F
R6272 T22514 T22505 punct ),5B
R6273 T22515 T22451 punct .,lead
R6274 T22517 T22518 prep Of,are
R6275 T22519 T22517 pobj interest,Of
R6276 T22520 T22521 det the,similarities
R6277 T22521 T22518 nsubj similarities,are
R6278 T22522 T22521 amod phenotypic,similarities
R6279 T22523 T22521 cc and,similarities
R6280 T22524 T22521 conj differences,similarities
R6281 T22525 T22521 prep between,similarities
R6282 T22526 T22527 poss our,mice
R6283 T22527 T22525 pobj mice,between
R6284 T22528 T22527 nmod KA,mice
R6285 T22529 T22527 amod mutant,mice
R6286 T22530 T22527 cc and,mice
R6287 T22531 T22532 det the,mice
R6288 T22532 T22527 conj mice,mice
R6289 T22533 T22534 advmod previously,described
R6290 T22534 T22532 amod described,mice
R6291 T22535 T22536 nmod K14,ΔN87βcat
R6292 T22536 T22532 nmod ΔN87βcat,mice
R6293 T22537 T22536 punct -,ΔN87βcat
R6294 T22538 T22532 amod transgenic,mice
R6295 T22539 T22532 acl expressing,mice
R6296 T22540 T22541 amod stable,catenin
R6297 T22541 T22539 dobj catenin,expressing
R6298 T22542 T22541 compound β,catenin
R6299 T22543 T22541 punct -,catenin
R6300 T22544 T22539 prep under,expressing
R6301 T22545 T22546 det the,control
R6302 T22546 T22544 pobj control,under
R6303 T22547 T22546 prep of,control
R6304 T22548 T22549 compound K14,promoter
R6305 T22549 T22547 pobj promoter,of
R6306 T22550 T22551 punct [,25
R6307 T22551 T22549 parataxis 25,promoter
R6308 T22552 T22551 punct ],25
R6309 T22553 T22549 cc and,promoter
R6310 T22554 T22555 nmod K14,Lef1
R6311 T22555 T22557 nmod Lef1,mice
R6312 T22556 T22555 punct -,Lef1
R6313 T22557 T22549 conj mice,promoter
R6314 T22558 T22555 amod transgenic,Lef1
R6315 T22559 T22560 punct [,27
R6316 T22560 T22557 parataxis 27,mice
R6317 T22561 T22560 punct ],27
R6318 T22562 T22518 punct .,are
R6319 T22564 T22565 advmod Surprisingly,shared
R6320 T22566 T22565 punct ", ",shared
R6321 T22567 T22568 poss our,mice
R6322 T22568 T22565 nsubj mice,shared
R6323 T22569 T22568 amod mutant,mice
R6324 T22570 T22571 amod more,similarities
R6325 T22571 T22565 dobj similarities,shared
R6326 T22572 T22565 prep with,shared
R6327 T22573 T22574 det the,mice
R6328 T22574 T22572 pobj mice,with
R6329 T22575 T22576 compound K14,Lef1
R6330 T22576 T22574 compound Lef1,mice
R6331 T22577 T22576 punct -,Lef1
R6332 T22578 T22565 prep than,shared
R6333 T22579 T22580 det the,mice
R6334 T22580 T22578 pobj mice,than
R6335 T22581 T22582 nmod K14,ΔN87βcat
R6336 T22582 T22580 nmod ΔN87βcat,mice
R6337 T22583 T22582 punct -,ΔN87βcat
R6338 T22584 T22580 amod transgenic,mice
R6339 T22585 T22565 punct .,shared
R6340 T22587 T22588 prep For,displayed
R6341 T22589 T22587 pobj example,For
R6342 T22590 T22588 punct ", ",displayed
R6343 T22591 T22592 det the,mice
R6344 T22592 T22588 nsubj mice,displayed
R6345 T22593 T22592 nmod KA,mice
R6346 T22594 T22592 amod mutant,mice
R6347 T22595 T22596 det the,whiskers
R6348 T22596 T22588 dobj whiskers,displayed
R6349 T22597 T22596 amod disoriented,whiskers
R6350 T22598 T22597 cc and,disoriented
R6351 T22599 T22597 conj short,disoriented
R6352 T22600 T22596 punct ", ",whiskers
R6353 T22601 T22596 amod curly,whiskers
R6354 T22602 T22596 acl seen,whiskers
R6355 T22603 T22602 prep in,seen
R6356 T22604 T22605 compound K14,Lef1but
R6357 T22605 T22603 pobj Lef1but,in
R6358 T22606 T22605 punct -,Lef1but
R6359 T22607 T22603 neg not,in
R6360 T22608 T22603 prep in,in
R6361 T22609 T22610 nmod K14,ΔN87βcat
R6362 T22610 T22612 nmod ΔN87βcat,mice
R6363 T22611 T22610 punct -,ΔN87βcat
R6364 T22612 T22608 pobj mice,in
R6365 T22613 T22612 amod transgenic,mice
R6366 T22614 T22588 punct .,displayed
R6367 T22616 T22617 prep In,displayed
R6368 T22618 T22616 pobj addition,In
R6369 T22619 T22617 punct ", ",displayed
R6370 T22620 T22621 nmod KA,mice
R6371 T22621 T22617 nsubj mice,displayed
R6372 T22622 T22621 amod mutant,mice
R6373 T22623 T22624 det a,coat
R6374 T22624 T22617 dobj coat,displayed
R6375 T22625 T22624 amod disorganized,coat
R6376 T22626 T22624 compound hair,coat
R6377 T22627 T22624 acl beginning,coat
R6378 T22628 T22627 prep with,beginning
R6379 T22629 T22630 det the,emergence
R6380 T22630 T22628 pobj emergence,with
R6381 T22631 T22630 prep of,emergence
R6382 T22632 T22633 amod neonatal,hairs
R6383 T22633 T22631 pobj hairs,of
R6384 T22634 T22633 punct ", ",hairs
R6385 T22635 T22633 amod similar,hairs
R6386 T22636 T22635 prep to,similar
R6387 T22637 T22636 pobj that,to
R6388 T22638 T22637 acl observed,that
R6389 T22639 T22638 prep in,observed
R6390 T22640 T22641 compound K14,Lef1
R6391 T22641 T22643 compound Lef1,mice
R6392 T22642 T22641 punct -,Lef1
R6393 T22643 T22639 pobj mice,in
R6394 T22644 T22617 punct ", ",displayed
R6395 T22645 T22646 mark whereas,was
R6396 T22646 T22617 advcl was,displayed
R6397 T22647 T22646 prep in,was
R6398 T22648 T22649 compound K14,ΔN87βcat
R6399 T22649 T22651 compound ΔN87βcat,mice
R6400 T22650 T22649 punct -,ΔN87βcat
R6401 T22651 T22647 pobj mice,in
R6402 T22652 T22646 punct ", ",was
R6403 T22653 T22654 amod embryonic,morphogenesis
R6404 T22654 T22646 nsubj morphogenesis,was
R6405 T22655 T22656 compound hair,follicle
R6406 T22656 T22654 compound follicle,morphogenesis
R6407 T22657 T22646 acomp unaffected,was
R6408 T22658 T22646 cc and,was
R6409 T22659 T22660 amod other,changes
R6410 T22660 T22662 nsubj changes,emerged
R6411 T22661 T22660 compound skin,changes
R6412 T22662 T22646 conj emerged,was
R6413 T22663 T22662 advmod only,emerged
R6414 T22664 T22662 advmod postnatally,emerged
R6415 T22665 T22617 punct .,displayed
R6416 T22667 T22668 det The,reason
R6417 T22668 T22669 nsubjpass reason,attributed
R6418 T22670 T22668 prep for,reason
R6419 T22671 T22672 det this,difference
R6420 T22672 T22670 pobj difference,for
R6421 T22673 T22669 aux could,attributed
R6422 T22674 T22669 auxpass be,attributed
R6423 T22675 T22669 prep to,attributed
R6424 T22676 T22675 pobj one,to
R6425 T22677 T22676 cc or,one
R6426 T22678 T22676 conj all,one
R6427 T22679 T22676 prep of,one
R6428 T22680 T22681 nummod three,factors
R6429 T22681 T22679 pobj factors,of
R6430 T22682 T22681 amod possible,factors
R6431 T22683 T22681 amod contributing,factors
R6432 T22684 T22669 punct .,attributed
R6433 T22686 T22687 punct (,1
R6434 T22687 T22688 meta 1,influence
R6435 T22689 T22687 punct ),1
R6436 T22690 T22691 mark Although,known
R6437 T22691 T22688 advcl known,influence
R6438 T22692 T22693 det the,promoter
R6439 T22693 T22691 nsubjpass promoter,known
R6440 T22694 T22693 compound K14,promoter
R6441 T22695 T22693 appos itself,promoter
R6442 T22696 T22691 auxpass is,known
R6443 T22697 T22698 aux to,initiate
R6444 T22698 T22691 xcomp initiate,known
R6445 T22699 T22700 det the,expression
R6446 T22700 T22698 dobj expression,initiate
R6447 T22701 T22698 prep at,initiate
R6448 T22702 T22701 pobj E9.5,at
R6449 T22703 T22691 cc and,known
R6450 T22704 T22691 conj elevated,known
R6451 T22705 T22704 advmod dramatically,elevated
R6452 T22706 T22704 prep by,elevated
R6453 T22707 T22706 pobj E13.5,by
R6454 T22708 T22709 punct –,E14.5
R6455 T22709 T22707 prep E14.5,E13.5
R6456 T22710 T22711 punct [,31
R6457 T22711 T22704 parataxis 31,elevated
R6458 T22712 T22711 nummod 19,31
R6459 T22713 T22711 punct ",",31
R6460 T22714 T22711 punct ],31
R6461 T22715 T22688 punct ", ",influence
R6462 T22716 T22717 amod many,factors
R6463 T22717 T22688 nsubj factors,influence
R6464 T22718 T22688 aux could,influence
R6465 T22719 T22720 det the,expression
R6466 T22720 T22688 dobj expression,influence
R6467 T22721 T22720 prep of,expression
R6468 T22722 T22723 compound promoter,transgene
R6469 T22723 T22725 compound transgene,construct
R6470 T22724 T22723 punct /,transgene
R6471 T22725 T22721 pobj construct,of
R6472 T22726 T22688 prep in,influence
R6473 T22727 T22728 amod transgenic,mice
R6474 T22728 T22726 pobj mice,in
R6475 T22729 T22688 punct .,influence
R6476 T22731 T22732 nsubj One,has
R6477 T22733 T22731 prep of,One
R6478 T22734 T22735 det the,considerations
R6479 T22735 T22733 pobj considerations,of
R6480 T22736 T22737 advmod most,important
R6481 T22737 T22735 amod important,considerations
R6482 T22738 T22739 aux to,do
R6483 T22739 T22732 xcomp do,has
R6484 T22740 T22739 prep with,do
R6485 T22741 T22742 det the,site
R6486 T22742 T22740 pobj site,with
R6487 T22743 T22742 compound integration,site
R6488 T22744 T22742 prep of,site
R6489 T22745 T22746 det the,transgene
R6490 T22746 T22744 pobj transgene,of
R6491 T22747 T22739 prep in,do
R6492 T22748 T22749 det the,genome
R6493 T22749 T22747 pobj genome,in
R6494 T22750 T22749 compound mouse,genome
R6495 T22751 T22732 punct .,has
R6496 T22753 T22754 prep Depending,vary
R6497 T22755 T22753 prep on,Depending
R6498 T22756 T22757 det the,location
R6499 T22757 T22755 pobj location,on
R6500 T22758 T22757 prep of,location
R6501 T22759 T22758 pobj integration,of
R6502 T22760 T22754 punct ", ",vary
R6503 T22761 T22762 det the,activity
R6504 T22762 T22754 nsubj activity,vary
R6505 T22763 T22762 amod transcriptional,activity
R6506 T22764 T22762 prep of,activity
R6507 T22765 T22766 advmod even,transgene
R6508 T22766 T22764 pobj transgene,of
R6509 T22767 T22766 det the,transgene
R6510 T22768 T22766 amod same,transgene
R6511 T22769 T22754 aux could,vary
R6512 T22770 T22754 advmod considerably,vary
R6513 T22771 T22754 punct .,vary
R6514 T22773 T22774 nsubj It,is
R6515 T22775 T22774 acomp possible,is
R6516 T22776 T22777 mark that,be
R6517 T22777 T22774 ccomp be,is
R6518 T22778 T22779 det the,lack
R6519 T22779 T22777 nsubj lack,be
R6520 T22780 T22779 amod apparent,lack
R6521 T22781 T22779 prep of,lack
R6522 T22782 T22783 compound ΔN87βcat,function
R6523 T22783 T22781 pobj function,of
R6524 T22784 T22779 prep in,lack
R6525 T22785 T22784 pobj embryogenesis,in
R6526 T22786 T22777 aux could,be
R6527 T22787 T22777 prep due,be
R6528 T22788 T22787 pcomp to,due
R6529 T22789 T22790 det the,expression
R6530 T22790 T22787 pobj expression,due
R6531 T22791 T22790 amod delayed,expression
R6532 T22792 T22791 cc or,delayed
R6533 T22793 T22791 conj weak,delayed
R6534 T22794 T22790 prep of,expression
R6535 T22795 T22796 det the,transgene
R6536 T22796 T22794 pobj transgene,of
R6537 T22797 T22798 compound K14,ΔN87βcat
R6538 T22798 T22796 compound ΔN87βcat,transgene
R6539 T22799 T22798 punct -,ΔN87βcat
R6540 T22800 T22790 prep compared,expression
R6541 T22801 T22800 prep to,compared
R6542 T22802 T22803 det the,promoter
R6543 T22803 T22801 pobj promoter,to
R6544 T22804 T22803 amod intrinsic,promoter
R6545 T22805 T22774 punct .,is
R6546 T22807 T22808 prep In,seen
R6547 T22809 T22807 pobj contrast,In
R6548 T22810 T22808 punct ", ",seen
R6549 T22811 T22812 npadvmod Cre,mediated
R6550 T22812 T22814 amod mediated,recombination
R6551 T22813 T22812 punct -,mediated
R6552 T22814 T22808 nsubjpass recombination,seen
R6553 T22815 T22808 auxpass is,seen
R6554 T22816 T22808 prep in,seen
R6555 T22817 T22818 compound E13.5,skin
R6556 T22818 T22816 pobj skin,in
R6557 T22819 T22818 prep of,skin
R6558 T22820 T22821 nmod K14,cre
R6559 T22821 T22823 nmod cre,mice
R6560 T22822 T22821 punct -,cre
R6561 T22823 T22819 pobj mice,of
R6562 T22824 T22823 amod transgenic,mice
R6563 T22825 T22823 acl used,mice
R6564 T22826 T22825 prep in,used
R6565 T22827 T22828 det this,study
R6566 T22828 T22826 pobj study,in
R6567 T22829 T22830 punct [,16
R6568 T22830 T22808 parataxis 16,seen
R6569 T22831 T22830 punct ],16
R6570 T22832 T22808 cc and,seen
R6571 T22833 T22834 compound K14,cre
R6572 T22834 T22836 npadvmod cre,mediated
R6573 T22835 T22834 punct -,cre
R6574 T22836 T22838 amod mediated,truncation
R6575 T22837 T22836 punct –,mediated
R6576 T22838 T22839 nsubj truncation,is
R6577 T22839 T22808 conj is,seen
R6578 T22840 T22838 prep of,truncation
R6579 T22841 T22842 det the,gene
R6580 T22842 T22840 pobj gene,of
R6581 T22843 T22842 compound Apc,gene
R6582 T22844 T22839 acomp likely,is
R6583 T22845 T22846 aux to,occurred
R6584 T22846 T22844 xcomp occurred,likely
R6585 T22847 T22846 aux have,occurred
R6586 T22848 T22846 prep by,occurred
R6587 T22849 T22848 pcomp then,by
R6588 T22850 T22846 punct ", ",occurred
R6589 T22851 T22846 prep in,occurred
R6590 T22852 T22851 pobj time,in
R6591 T22853 T22852 prep for,time
R6592 T22854 T22855 det the,wave
R6593 T22855 T22853 pobj wave,for
R6594 T22856 T22855 amod second,wave
R6595 T22857 T22855 prep of,wave
R6596 T22858 T22859 compound hair,follicle
R6597 T22859 T22860 compound follicle,morphgenesis
R6598 T22860 T22857 pobj morphgenesis,of
R6599 T22861 T22808 punct .,seen
R6600 T22863 T22864 punct (,2
R6601 T22864 T22865 meta 2,is
R6602 T22866 T22864 punct ),2
R6603 T22867 T22868 det Another,fact
R6604 T22868 T22865 nsubj fact,is
R6605 T22869 T22868 amod important,fact
R6606 T22870 T22871 mark that,confined
R6607 T22871 T22865 ccomp confined,is
R6608 T22872 T22871 prep in,confined
R6609 T22873 T22874 det the,model
R6610 T22874 T22872 pobj model,in
R6611 T22875 T22874 amod aforementioned,model
R6612 T22876 T22874 amod transgenic,model
R6613 T22877 T22878 det the,overexpression
R6614 T22878 T22871 nsubjpass overexpression,confined
R6615 T22879 T22878 prep of,overexpression
R6616 T22880 T22879 pobj transgene,of
R6617 T22881 T22871 auxpass is,confined
R6618 T22882 T22871 prep to,confined
R6619 T22883 T22884 det the,cells
R6620 T22884 T22882 pobj cells,to
R6621 T22885 T22884 amod basal,cells
R6622 T22886 T22884 prep of,cells
R6623 T22887 T22888 det the,epidermis
R6624 T22888 T22886 pobj epidermis,of
R6625 T22889 T22884 cc and,cells
R6626 T22890 T22891 det the,ORS
R6627 T22891 T22884 conj ORS,cells
R6628 T22892 T22891 prep of,ORS
R6629 T22893 T22894 compound hair,follicles
R6630 T22894 T22892 pobj follicles,of
R6631 T22895 T22884 punct ", ",cells
R6632 T22896 T22897 advmod where,is
R6633 T22897 T22884 relcl is,cells
R6634 T22898 T22899 det the,promoter
R6635 T22899 T22897 nsubj promoter,is
R6636 T22900 T22899 compound K14,promoter
R6637 T22901 T22897 acomp active,is
R6638 T22902 T22865 punct .,is
R6639 T22904 T22905 det The,expression
R6640 T22905 T22906 nsubj expression,is
R6641 T22907 T22905 prep of,expression
R6642 T22908 T22907 pobj transgene,of
R6643 T22909 T22906 advmod hence,is
R6644 T22910 T22906 acomp transient,is
R6645 T22911 T22906 cc and,is
R6646 T22912 T22906 conj stops,is
R6647 T22913 T22914 mark once,differentiate
R6648 T22914 T22912 advcl differentiate,stops
R6649 T22915 T22916 npadvmod K14,expressing
R6650 T22916 T22918 amod expressing,cells
R6651 T22917 T22916 punct -,expressing
R6652 T22918 T22914 nsubj cells,differentiate
R6653 T22919 T22914 advmod terminally,differentiate
R6654 T22920 T22906 punct .,is
R6655 T22922 T22923 prep In,result
R6656 T22924 T22922 pobj contrast,In
R6657 T22925 T22923 punct ", ",result
R6658 T22926 T22923 prep in,result
R6659 T22927 T22928 poss our,model
R6660 T22928 T22926 pobj model,in
R6661 T22929 T22923 punct ", ",result
R6662 T22930 T22931 compound K14,cre
R6663 T22931 T22933 npadvmod cre,mediated
R6664 T22932 T22931 punct -,cre
R6665 T22933 T22935 amod mediated,deletion
R6666 T22934 T22933 punct –,mediated
R6667 T22935 T22923 nsubj deletion,result
R6668 T22936 T22935 prep of,deletion
R6669 T22937 T22936 pobj Apc,of
R6670 T22938 T22923 aux would,result
R6671 T22939 T22923 prep in,result
R6672 T22940 T22941 compound Apc,mutation
R6673 T22941 T22939 pobj mutation,in
R6674 T22942 T22943 preconj not,in
R6675 T22943 T22923 prep in,result
R6676 T22944 T22942 advmod only,not
R6677 T22945 T22946 nmod K14,cells
R6678 T22946 T22943 pobj cells,in
R6679 T22947 T22946 nmod promoter,cells
R6680 T22948 T22946 amod active,cells
R6681 T22949 T22923 punct ", ",result
R6682 T22950 T22923 cc but,result
R6683 T22951 T22923 conj remain,result
R6684 T22952 T22951 advmod so,remain
R6685 T22953 T22951 prep in,remain
R6686 T22954 T22955 det all,layers
R6687 T22955 T22953 pobj layers,in
R6688 T22956 T22955 compound cell,layers
R6689 T22957 T22958 dep that,derived
R6690 T22958 T22955 relcl derived,layers
R6691 T22959 T22958 prep from,derived
R6692 T22960 T22961 det the,progenitors
R6693 T22961 T22959 pobj progenitors,from
R6694 T22962 T22963 nmod K14,promoter
R6695 T22963 T22961 nmod promoter,progenitors
R6696 T22964 T22961 amod active,progenitors
R6697 T22965 T22923 punct .,result
R6698 T22967 T22968 det These,derivatives
R6699 T22968 T22969 nsubj derivatives,include
R6700 T22970 T22971 det the,epidermis
R6701 T22971 T22969 dobj epidermis,include
R6702 T22972 T22971 amod suprabasal,epidermis
R6703 T22973 T22971 cc and,epidermis
R6704 T22974 T22975 det the,epithelium
R6705 T22975 T22971 conj epithelium,epidermis
R6706 T22976 T22975 amod entire,epithelium
R6707 T22977 T22975 prep of,epithelium
R6708 T22978 T22979 det the,follicle
R6709 T22979 T22977 pobj follicle,of
R6710 T22980 T22979 compound hair,follicle
R6711 T22981 T22969 punct .,include
R6712 T22983 T22984 nsubj Stabilization,account
R6713 T22985 T22983 prep of,Stabilization
R6714 T22986 T22987 compound β,catenin
R6715 T22987 T22985 pobj catenin,of
R6716 T22988 T22987 punct -,catenin
R6717 T22989 T22983 prep in,Stabilization
R6718 T22990 T22991 det a,population
R6719 T22991 T22989 pobj population,in
R6720 T22992 T22991 amod broader,population
R6721 T22993 T22991 prep of,population
R6722 T22994 T22993 pobj cells,of
R6723 T22995 T22984 aux could,account
R6724 T22996 T22984 prep for,account
R6725 T22997 T22996 pobj some,for
R6726 T22998 T22997 prep of,some
R6727 T22999 T23000 det the,differences
R6728 T23000 T22998 pobj differences,of
R6729 T23001 T23000 amod phenotypic,differences
R6730 T23002 T22984 punct .,account
R6731 T23004 T23005 advmod However,detect
R6732 T23006 T23005 punct ", ",detect
R6733 T23007 T23005 nsubj we,detect
R6734 T23008 T23005 aux did,detect
R6735 T23009 T23005 neg not,detect
R6736 T23010 T23011 det any,expression
R6737 T23011 T23005 dobj expression,detect
R6738 T23012 T23011 amod elevated,expression
R6739 T23013 T23014 compound β,catenin
R6740 T23014 T23011 compound catenin,expression
R6741 T23015 T23014 punct -,catenin
R6742 T23016 T23005 prep in,detect
R6743 T23017 T23018 preconj either,cells
R6744 T23018 T23016 pobj cells,in
R6745 T23019 T23020 npadvmod K1,positive
R6746 T23020 T23018 amod positive,cells
R6747 T23021 T23019 punct -,K1
R6748 T23022 T23019 cc or,K1
R6749 T23023 T23019 conj K6,K1
R6750 T23024 T23020 punct -,positive
R6751 T23025 T23018 amod differentiated,cells
R6752 T23026 T23005 prep in,detect
R6753 T23027 T23028 amod postnatal,skin
R6754 T23028 T23026 pobj skin,in
R6755 T23029 T23028 amod mutant,skin
R6756 T23030 T23005 punct .,detect
R6757 T23032 T23033 nsubj This,indicates
R6758 T23034 T23035 mark that,take
R6759 T23035 T23033 ccomp take,indicates
R6760 T23036 T23035 prep despite,take
R6761 T23037 T23038 det the,absence
R6762 T23038 T23036 pobj absence,despite
R6763 T23039 T23038 prep of,absence
R6764 T23040 T23039 pobj Apc,of
R6765 T23041 T23038 cc and,absence
R6766 T23042 T23043 amod potential,stabilization
R6767 T23043 T23038 conj stabilization,absence
R6768 T23044 T23043 prep of,stabilization
R6769 T23045 T23046 compound β,catenin
R6770 T23046 T23044 pobj catenin,of
R6771 T23047 T23046 punct -,catenin
R6772 T23048 T23038 prep in,absence
R6773 T23049 T23048 pobj derivatives,in
R6774 T23050 T23049 prep of,derivatives
R6775 T23051 T23052 npadvmod K14,expressing
R6776 T23052 T23054 amod expressing,progenitors
R6777 T23053 T23052 punct -,expressing
R6778 T23054 T23050 pobj progenitors,of
R6779 T23055 T23035 punct ", ",take
R6780 T23056 T23057 amod elevated,expression
R6781 T23057 T23035 nsubj expression,take
R6782 T23058 T23059 compound β,catenin
R6783 T23059 T23057 compound catenin,expression
R6784 T23060 T23059 punct -,catenin
R6785 T23061 T23057 punct ", ",expression
R6786 T23062 T23057 cc and,expression
R6787 T23063 T23064 amod subsequent,determination
R6788 T23064 T23057 conj determination,expression
R6789 T23065 T23066 compound cell,fate
R6790 T23066 T23064 compound fate,determination
R6791 T23067 T23035 aux may,take
R6792 T23068 T23035 advmod only,take
R6793 T23069 T23035 dobj place,take
R6794 T23070 T23035 prep in,take
R6795 T23071 T23072 amod basal,cells
R6796 T23072 T23070 pobj cells,in
R6797 T23073 T23033 punct .,indicates
R6798 T23075 T23076 punct (,3
R6799 T23076 T23077 meta 3,exclude
R6800 T23078 T23076 punct ),3
R6801 T23079 T23077 nsubj We,exclude
R6802 T23080 T23077 aux can,exclude
R6803 T23081 T23077 neg not,exclude
R6804 T23082 T23083 det the,possibility
R6805 T23083 T23077 dobj possibility,exclude
R6806 T23084 T23085 mark that,contributed
R6807 T23085 T23083 acl contributed,possibility
R6808 T23086 T23085 prep given,contributed
R6809 T23087 T23088 det the,properties
R6810 T23088 T23086 pobj properties,given
R6811 T23089 T23088 amod multifunctional,properties
R6812 T23090 T23088 prep of,properties
R6813 T23091 T23090 pobj Apc,of
R6814 T23092 T23085 punct ", ",contributed
R6815 T23093 T23085 nsubj disruption,contributed
R6816 T23094 T23093 prep of,disruption
R6817 T23095 T23096 poss its,functions
R6818 T23096 T23094 pobj functions,of
R6819 T23097 T23096 amod other,functions
R6820 T23098 T23097 prep than,other
R6821 T23099 T23100 advmod down,regulation
R6822 T23100 T23098 pobj regulation,than
R6823 T23101 T23100 punct -,regulation
R6824 T23102 T23100 prep of,regulation
R6825 T23103 T23104 compound β,catenin
R6826 T23104 T23102 pobj catenin,of
R6827 T23105 T23104 punct -,catenin
R6828 T23106 T23085 aux may,contributed
R6829 T23107 T23085 advmod also,contributed
R6830 T23108 T23085 aux have,contributed
R6831 T23109 T23085 prep to,contributed
R6832 T23110 T23111 det the,phenotype
R6833 T23111 T23109 pobj phenotype,to
R6834 T23112 T23111 amod observed,phenotype
R6835 T23113 T23111 amod overt,phenotype
R6836 T23114 T23077 punct .,exclude

2_test

Id Subject Object Predicate Lexical cue
17002498-11841536-85593519 268-270 11841536 denotes 24
17002498-9845363-85593520 650-652 9845363 denotes 25
17002498-10409498-85593520 650-652 10409498 denotes 25
17002498-7537238-85593520 650-652 7537238 denotes 25
17002498-11371349-85593521 890-892 11371349 denotes 28
17002498-12015971-85593521 890-892 12015971 denotes 28
17002498-7958926-85593521 890-892 7958926 denotes 28
17002498-9845363-85593522 1934-1936 9845363 denotes 25
17002498-7537238-85593523 1968-1970 7537238 denotes 27
17002498-7525178-85593524 2745-2747 7525178 denotes 19
17002498-8990189-85593525 2748-2750 8990189 denotes 31
17002498-11694875-85593526 3385-3387 11694875 denotes 16
T58138 268-270 11841536 denotes 24
T2579 650-652 9845363 denotes 25
T26992 650-652 10409498 denotes 25
T7229 650-652 7537238 denotes 25
T24052 890-892 11371349 denotes 28
T27200 890-892 12015971 denotes 28
T60441 890-892 7958926 denotes 28
T55311 1934-1936 9845363 denotes 25
T47275 1968-1970 7537238 denotes 27
T44354 2745-2747 7525178 denotes 19
T70725 2748-2750 8990189 denotes 31
T26365 3385-3387 11694875 denotes 16