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PMC:1564426 / 39022-46074 JSONTXT

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craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21897 0-3 PR_EXT:000004122 denotes Apc
T21898 8-21 UBERON:0002073 denotes Hair Follicle
T21899 8-35 GO:0031069 denotes Hair Follicle Morphogenesis
T21900 54-67 UBERON:0002073 denotes hair follicle
T21901 54-79 GO:0001942 denotes hair follicle development
T21902 133-141 UBERON_EXT:placode denotes placodes
T21903 157-167 UBERON:0000483 denotes epithelium
T21904 171-179 GO_EXT:reaction_or_response denotes response
T21905 193-199 UBERON_EXT:skin_or_dermis denotes dermal
T21906 256-265 CHEBI:36357 denotes molecules
T21907 290-297 UBERON_EXT:placode denotes placode
T21908 363-384 GO:0016055 denotes Wnt signaling pathway
T21909 392-398 UBERON:0002067 denotes dermis
T21910 441-447 UBERON_EXT:skin_or_dermis denotes dermal
T21911 483-493 UBERON:0000483 denotes epithelial
T21912 494-503 PR_EXT:000002198 denotes β-catenin
T21913 504-513 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21914 518-528 GO:0010467 denotes expression
T21915 532-542 CHEBI_SO_EXT:N_terminus_or_N_terminal_region denotes N-terminal
T21916 543-552 SO_EXT:sequence_truncation_process denotes truncated
T21917 589-598 PR_EXT:000002198 denotes β-catenin
T21918 610-620 GO:0010467 denotes expression
T21919 624-628 PR_EXT:000009751 denotes Lef1
T21920 646-655 UBERON_EXT:follicle denotes follicles
T21921 664-669 NCBITaxon:10088 denotes mouse
T21922 674-679 NCBITaxon_UBERON_EXT:chick denotes chick
T21923 680-684 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T21924 706-721 GO_EXT:negative_regulation denotes down-regulation
T21925 725-734 PR_EXT:000002198 denotes β-catenin
T21926 735-744 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21927 754-758 PR_EXT:000009751 denotes Lef1
T21928 778-788 GO:0010467 denotes expression
T21929 796-805 CHEBI_EXT:35222 denotes inhibitor
T21930 806-810 PR_EXT:000006499 denotes Dkk1
T21931 826-834 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T21932 838-847 PR_EXT:000002198 denotes β-catenin
T21933 851-860 UBERON:0007376 denotes epidermis
T21934 881-890 UBERON:0010419 denotes vibrissae
T21935 900-906 UBERON:0010509 denotes pelage
T21936 907-916 UBERON_EXT:follicle denotes follicles
T21937 920-924 NCBITaxon:10088 denotes mice
T21938 951-954 PR_EXT:000009454 denotes K14
T21939 962-965 PR_EXT:000004122 denotes Apc
T21940 974-992 UBERON:0000924 denotes embryonic ectoderm
T21941 1061-1073 UBERON:0005086 denotes hair placode
T21942 1089-1097 UBERON_EXT:follicle denotes follicle
T21943 1098-1111 GO:0009653 denotes morphogenesis
T21944 1183-1193 UBERON:0008281 denotes tooth buds
T21945 1264-1274 UBERON:0000483 denotes epithelial
T21946 1275-1284 PR_EXT:000002198 denotes β-catenin
T21947 1285-1294 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T21948 1302-1309 UBERON_EXT:placode denotes placode
T21949 1344-1347 PR_EXT:000004122 denotes Apc
T21950 1351-1367 _FRAGMENT denotes specification of
T21951 1389-1399 GO:0048866 denotes stem cells
T21952 1378-1388 _FRAGMENT denotes ectodermal
T21953 1394-1399 GO:0001715 denotes cells
T21954 1368-1388 UBERON:0000924 denotes embryonic ectodermal
T21955 1368-1377 _FRAGMENT denotes embryonic
T21956 1389-1399 CL:0002322 denotes stem cells
T21957 1394-1399 CL:0000221 denotes cells
T21958 1394-1399 CL_GO_EXT:cell denotes cells
T21959 1413-1426 UBERON:0002073 denotes hair follicle
T21960 1446-1449 PR_EXT:000004122 denotes Apc
T21961 1453-1468 GO_EXT:negative_regulation denotes down-regulation
T21962 1472-1481 PR_EXT:000002198 denotes β-catenin
T21963 1491-1494 PR_EXT:000004122 denotes Apc
T21964 1528-1538 GO:0010467 denotes expression
T21965 1542-1551 PR_EXT:000002198 denotes β-catenin
T21966 1555-1565 UBERON:0000924 denotes ectodermal
T21967 1555-1571 CL:0000221 denotes ectodermal cells
T21968 1566-1571 CL_GO_EXT:cell denotes cells
T21969 1583-1595 UBERON:0005086 denotes hair placode
T21970 1583-1605 GO:0060789 denotes hair placode formation
T21971 1631-1641 UBERON_EXT:follicle denotes follicular
T21972 1642-1648 GO_EXT:biological_growth_entity_or_process denotes growth
T21973 1664-1673 UBERON:0000922 denotes embryonic
T21974 1674-1683 UBERON:0007376 denotes epidermis
T21975 1699-1707 UBERON:0013623 denotes footpads
T21976 1724-1728 UBERON:0001037 denotes hair
T21977 1837-1843 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T21978 1844-1848 NCBITaxon:10088 denotes mice
T21979 1878-1881 PR_EXT:000009454 denotes K14
T21980 1891-1901 SO_EXT:transgenic_entity denotes transgenic
T21981 1902-1906 NCBITaxon:10088 denotes mice
T21982 1907-1917 GO:0010467 denotes expressing
T21983 1925-1934 PR_EXT:000002198 denotes β-catenin
T21984 1945-1952 GO:0065007 denotes control
T21985 1956-1959 PR_EXT:000009454 denotes K14
T21986 1960-1968 SO_EXT:0000167 denotes promoter
T21987 1978-1981 PR_EXT:000009454 denotes K14
T21988 1982-1986 PR_EXT:000009751 denotes Lef1
T21989 1987-1997 SO_EXT:transgenic_entity denotes transgenic
T21990 1998-2002 NCBITaxon:10088 denotes mice
T21991 2027-2033 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T21992 2034-2038 NCBITaxon:10088 denotes mice
T21993 2073-2076 PR_EXT:000009454 denotes K14
T21994 2077-2081 PR_EXT:000009751 denotes Lef1
T21995 2082-2086 NCBITaxon:10088 denotes mice
T21996 2096-2099 PR_EXT:000009454 denotes K14
T21997 2109-2119 SO_EXT:transgenic_entity denotes transgenic
T21998 2120-2124 NCBITaxon:10088 denotes mice
T21999 2146-2152 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22000 2153-2157 NCBITaxon:10088 denotes mice
T22001 2218-2221 PR_EXT:000009454 denotes K14
T22002 2237-2240 PR_EXT:000009454 denotes K14
T22003 2250-2260 SO_EXT:transgenic_entity denotes transgenic
T22004 2261-2265 NCBITaxon:10088 denotes mice
T22005 2283-2289 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22006 2290-2294 NCBITaxon:10088 denotes mice
T22007 2320-2329 UBERON:0010166 denotes hair coat
T22008 2362-2370 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T22009 2371-2376 UBERON:0001037 denotes hairs
T22010 2406-2409 PR_EXT:000009454 denotes K14
T22011 2410-2414 PR_EXT:000009751 denotes Lef1
T22012 2415-2419 NCBITaxon:10088 denotes mice
T22013 2432-2435 PR_EXT:000009454 denotes K14
T22014 2445-2449 NCBITaxon:10088 denotes mice
T22015 2451-2460 UBERON:0000922 denotes embryonic
T22016 2451-2460 _FRAGMENT denotes embryonic
T22017 2475-2488 GO:0048598 denotes morphogenesis
T22018 2461-2474 UBERON:0002073 denotes hair follicle
T22019 2461-2488 GO:0031069 denotes hair follicle morphogenesis
T22020 2514-2518 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22021 2544-2551 GO:0007567 denotes natally
T22022 2675-2678 PR_EXT:000009454 denotes K14
T22023 2679-2687 SO_EXT:0000167 denotes promoter
T22024 2720-2730 GO:0010467 denotes expression
T22025 2822-2832 GO:0010467 denotes expression
T22026 2836-2844 SO_EXT:0000167 denotes promoter
T22027 2845-2854 SO_EXT:0000902 denotes transgene
T22028 2855-2864 SO_EXT:engineered_biological_sequence denotes construct
T22029 2868-2878 SO_EXT:transgenic_entity denotes transgenic
T22030 2879-2883 NCBITaxon:10088 denotes mice
T22031 2945-2961 SO_EXT:0000366 denotes integration site
T22032 2969-2978 SO_EXT:0000902 denotes transgene
T22033 2986-2991 NCBITaxon:10088 denotes mouse
T22034 2992-2998 SO_EXT:0001026 denotes genome
T22035 3017-3040 SO_EXT:0000366 denotes location of integration
T22036 3046-3061 GO_EXT:transcription denotes transcriptional
T22037 3088-3097 SO_EXT:0000902 denotes transgene
T22038 3185-3198 GO:0009790 denotes embryogenesis
T22039 3235-3245 GO:0010467 denotes expression
T22040 3253-3256 PR_EXT:000009454 denotes K14
T22041 3266-3275 SO_EXT:0000902 denotes transgene
T22042 3302-3310 SO_EXT:0000167 denotes promoter
T22043 3338-3351 GO_SO_EXT:sequence_rearrangement_process denotes recombination
T22044 3369-3373 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22045 3377-3380 PR_EXT:000009454 denotes K14
T22046 3385-3395 SO_EXT:transgenic_entity denotes transgenic
T22047 3396-3400 NCBITaxon:10088 denotes mice
T22048 3429-3432 PR_EXT:000009454 denotes K14
T22049 3446-3456 SO_EXT:sequence_truncation_entity_or_process denotes truncation
T22050 3464-3467 PR_EXT:000004122 denotes Apc
T22051 3468-3472 SO_EXT:0000704 denotes gene
T22052 3540-3553 UBERON:0002073 denotes hair follicle
T22053 3540-3566 GO:0031069 denotes hair follicle morphgenesis
T22054 3625-3635 SO_EXT:transgenic_entity denotes transgenic
T22055 3650-3660 GO:0010467 denotes expression
T22056 3664-3673 SO_EXT:0000902 denotes transgene
T22057 3693-3707 _FRAGMENT denotes basal cells of
T22058 3712-3721 CL:0002187 denotes epidermis
T22059 3699-3704 CL_GO_EXT:cell denotes cells
T22060 3699-3707 _FRAGMENT denotes cells of
T22061 3730-3751 CL:0002561 denotes ORS of hair follicles
T22062 3712-3721 UBERON:0007376 denotes epidermis
T22063 3730-3751 UBERON:0005942 denotes ORS of hair follicles
T22064 3763-3766 PR_EXT:000009454 denotes K14
T22065 3767-3775 SO_EXT:0000167 denotes promoter
T22066 3791-3801 GO:0010467 denotes expression
T22067 3805-3814 SO_EXT:0000902 denotes transgene
T22068 3849-3852 PR_EXT:000009454 denotes K14
T22069 3853-3863 GO:0010467 denotes expressing
T22070 3864-3869 CL_GO_EXT:cell denotes cells
T22071 3881-3894 GO_RO_EXT:developmental_differentiation_process denotes differentiate
T22072 3923-3926 PR_EXT:000009454 denotes K14
T22073 3940-3948 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T22074 3952-3955 PR_EXT:000004122 denotes Apc
T22075 3972-3975 PR_EXT:000004122 denotes Apc
T22076 3976-3984 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T22077 3997-4000 PR_EXT:000009454 denotes K14
T22078 4001-4009 SO_EXT:0000167 denotes promoter
T22079 4017-4022 CL_GO_EXT:cell denotes cells
T22080 4045-4049 CL_GO_EXT:cell denotes cell
T22081 4045-4056 UBERON:0000119 denotes cell layers
T22082 4079-4082 PR_EXT:000009454 denotes K14
T22083 4083-4091 SO_EXT:0000167 denotes promoter
T22084 4142-4162 UBERON:0010402 denotes suprabasal epidermis
T22085 4178-4188 UBERON:0000483 denotes epithelium
T22086 4196-4209 UBERON:0002073 denotes hair follicle
T22087 4228-4237 PR_EXT:000002198 denotes β-catenin
T22088 4251-4270 UBERON_EXT:cell_clump_or_cluster_or_group_or_mass_or_population denotes population of cells
T22089 4265-4270 CL_GO_EXT:cell denotes cells
T22090 4365-4374 PR_EXT:000002198 denotes β-catenin
T22091 4375-4385 GO:0010467 denotes expression
T22092 4396-4398 PR_EXT:000009450 denotes K1
T22093 4403-4405 PR_EXT:keratin_6 denotes K6
T22094 4415-4429 GO_PATO_RO_EXT:developmental_differentiation_process_or_quality denotes differentiated
T22095 4430-4435 CL_GO_EXT:cell denotes cells
T22096 4443-4448 GO:0007567 denotes natal
T22097 4449-4455 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22098 4456-4460 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22099 4505-4508 PR_EXT:000004122 denotes Apc
T22100 4540-4549 PR_EXT:000002198 denotes β-catenin
T22101 4568-4571 PR_EXT:000009454 denotes K14
T22102 4572-4582 GO:0010467 denotes expressing
T22103 4605-4614 PR_EXT:000002198 denotes β-catenin
T22104 4615-4625 GO:0010467 denotes expression
T22105 4642-4646 CL_GO_EXT:cell denotes cell
T22106 4642-4665 GO:0001709 denotes cell fate determination
T22107 4689-4700 CL:0000646 denotes basal cells
T22108 4695-4700 CL_GO_EXT:cell denotes cells
T22109 4785-4788 PR_EXT:000004122 denotes Apc
T22110 4829-4844 GO_EXT:negative_regulation denotes down-regulation
T22111 4848-4857 PR_EXT:000002198 denotes β-catenin
T22112 4944-4950 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22113 4951-4955 NCBITaxon:10088 denotes mice
T22114 4978-4988 SO_EXT:transgenic_entity denotes transgenic
T22115 4989-4993 NCBITaxon:10088 denotes mice
T22116 5067-5080 UBERON:0002073 denotes hair follicle
T22117 5067-5094 GO:0031069 denotes hair follicle morphogenesis
T22118 5096-5099 PR_EXT:000009454 denotes K14
T22119 5115-5118 PR_EXT:000004122 denotes Apc
T22120 5148-5158 UBERON:0008281 denotes tooth buds
T22121 5170-5184 UBERON:0002073 denotes hair follicles
T22122 5251-5261 UBERON:0000483 denotes epithelium
T22123 5266-5276 UBERON:0003104 denotes mesenchyme
T22124 5322-5332 UBERON:0008281 denotes tooth buds
T22125 5342-5349 NCBITaxon:33208 denotes animals
T22126 5353-5363 GO:0010467 denotes expressing
T22127 5364-5368 PR_EXT:000009751 denotes Lef1
T22128 5415-5420 GO:0007567 denotes birth
T22129 5447-5450 PR_EXT:000004122 denotes Apc
T22130 5481-5490 UBERON:0000922 denotes embryonic
T22131 5481-5490 _FRAGMENT denotes embryonic
T22132 5497-5508 GO:0009790 denotes development
T22133 5491-5496 UBERON:0001091 denotes tooth
T22134 5540-5543 PR_EXT:000014841 denotes Shh
T22135 5544-5554 GO:0010467 denotes expression
T22136 5564-5573 UBERON:0000922 denotes embryonic
T22137 5574-5589 UBERON:0002424 denotes oral epithelium
T22138 5652-5662 UBERON:0008281 denotes tooth buds
T22139 5717-5722 UBERON:0001091 denotes teeth
T22140 5750-5756 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22141 5757-5761 NCBITaxon:10088 denotes mice
T22142 5771-5776 UBERON:0001091 denotes tooth
T22143 5802-5807 UBERON:0001091 denotes tooth
T22144 5834-5840 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22145 5841-5845 NCBITaxon:10088 denotes mice
T22146 5879-5889 SO_EXT:transgenic_entity denotes transgenic
T22147 5890-5894 NCBITaxon:10088 denotes mice
T22148 5903-5910 GO:0007567 denotes natally
T22149 5911-5917 GO_EXT:fatality_or_lethality denotes lethal
T22150 5931-5937 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22151 5938-5942 NCBITaxon:10088 denotes mice
T22152 6020-6026 UBERON:0000062 denotes organs
T22153 6033-6037 NCBITaxon:10088 denotes mice
T22154 6067-6076 GO_EXT:fatality_or_lethality denotes lethality
T22155 6109-6116 SO_EXT:sequence_altered_entity denotes mutants
T22156 6180-6184 CHEBI_EXT:33290 denotes food
T22157 6194-6201 UBERON:0000945 denotes stomach
T22158 6221-6228 SO_EXT:sequence_altered_entity denotes mutants
T22159 6240-6244 GO:0016265 denotes died
T22160 6260-6266 UBERON_EXT:skin_or_dermis denotes Dermal
T22161 6267-6270 CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue denotes fat
T22162 6290-6296 SO_EXT:sequence_altered_entity_or_alteration_process denotes mutant
T22163 6297-6301 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22164 6372-6377 UBERON:0001091 denotes teeth
T22165 6407-6414 SO_EXT:sequence_altered_entity denotes mutants
T22166 6441-6445 NCBITaxon_UBERON_EXT:pup denotes pups
T22167 6457-6463 GO:0001967 denotes nursed
T22168 6508-6513 UBERON:0001091 denotes teeth
T22169 6542-6547 GO:0016265 denotes death
T22170 6603-6608 UBERON:0001091 denotes teeth
T22171 6613-6627 UBERON:0001911 denotes mammary glands
T22172 6650-6654 NCBITaxon:10088 denotes mice
T22173 6668-6672 PR_EXT:000009751 denotes Lef1
T22174 6689-6699 GO:0010467 denotes expressing
T22175 6700-6704 PR_EXT:000006499 denotes Dkk1
T22176 6823-6832 UBERON:0008281 denotes tooth bud
T22177 6872-6877 UBERON:0001091 denotes teeth
T22178 6882-6886 NCBITaxon:10088 denotes mice
T22179 6921-6925 UBERON:0000104 denotes life
T22180 6985-6994 PR_EXT:000002198 denotes β-catenin
T22181 7012-7016 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T22182 7021-7026 UBERON:0001091 denotes tooth
R5945 T21951 T21950 _lexicallyChainedTo stem cells,specification of
R5946 T21952 T21950 _lexicallyChainedTo ectodermal,specification of
R5947 T21953 T21952 _lexicallyChainedTo cells,ectodermal
R5948 T21956 T21955 _lexicallyChainedTo stem cells,embryonic
R5949 T21957 T21952 _lexicallyChainedTo cells,ectodermal
R5950 T22017 T22016 _lexicallyChainedTo morphogenesis,embryonic
R5951 T22058 T22057 _lexicallyChainedTo epidermis,basal cells of
R5952 T22061 T22060 _lexicallyChainedTo ORS of hair follicles,cells of
R5953 T22132 T22131 _lexicallyChainedTo development,embryonic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21686 0-3 PR:000004122 denotes Apc
T21687 8-21 UBERON:0002073 denotes Hair Follicle
T21688 8-35 GO:0031069 denotes Hair Follicle Morphogenesis
T21689 54-67 UBERON:0002073 denotes hair follicle
T21690 54-79 GO:0001942 denotes hair follicle development
T21691 157-167 UBERON:0000483 denotes epithelium
T21692 256-265 CHEBI:36357 denotes molecules
T21693 363-384 GO:0016055 denotes Wnt signaling pathway
T21694 392-398 UBERON:0002067 denotes dermis
T21695 483-493 UBERON:0000483 denotes epithelial
T21696 494-503 PR:000002198 denotes β-catenin
T21697 518-528 GO:0010467 denotes expression
T21698 589-598 PR:000002198 denotes β-catenin
T21699 610-620 GO:0010467 denotes expression
T21700 624-628 PR:000009751 denotes Lef1
T21701 664-669 NCBITaxon:10088 denotes mouse
T21702 725-734 PR:000002198 denotes β-catenin
T21703 754-758 PR:000009751 denotes Lef1
T21704 778-788 GO:0010467 denotes expression
T21705 796-805 CHEBI:35222 denotes inhibitor
T21706 806-810 PR:000006499 denotes Dkk1
T21707 838-847 PR:000002198 denotes β-catenin
T21708 851-860 UBERON:0007376 denotes epidermis
T21709 881-890 UBERON:0010419 denotes vibrissae
T21710 900-906 UBERON:0010509 denotes pelage
T21711 920-924 NCBITaxon:10088 denotes mice
T21712 951-954 PR:000009454 denotes K14
T21713 962-965 PR:000004122 denotes Apc
T21714 974-992 UBERON:0000924 denotes embryonic ectoderm
T21715 1061-1073 UBERON:0005086 denotes hair placode
T21716 1098-1111 GO:0009653 denotes morphogenesis
T21717 1183-1193 UBERON:0008281 denotes tooth buds
T21718 1264-1274 UBERON:0000483 denotes epithelial
T21719 1275-1284 PR:000002198 denotes β-catenin
T21720 1344-1347 PR:000004122 denotes Apc
T21721 1351-1367 _FRAGMENT denotes specification of
T21722 1389-1399 GO:0048866 denotes stem cells
T21723 1378-1388 _FRAGMENT denotes ectodermal
T21724 1394-1399 GO:0001715 denotes cells
T21725 1368-1388 UBERON:0000924 denotes embryonic ectodermal
T21726 1368-1377 _FRAGMENT denotes embryonic
T21727 1389-1399 CL:0002322 denotes stem cells
T21728 1394-1399 CL:0000221 denotes cells
T21729 1413-1426 UBERON:0002073 denotes hair follicle
T21730 1446-1449 PR:000004122 denotes Apc
T21731 1472-1481 PR:000002198 denotes β-catenin
T21732 1491-1494 PR:000004122 denotes Apc
T21733 1528-1538 GO:0010467 denotes expression
T21734 1542-1551 PR:000002198 denotes β-catenin
T21735 1555-1565 UBERON:0000924 denotes ectodermal
T21736 1555-1571 CL:0000221 denotes ectodermal cells
T21737 1583-1595 UBERON:0005086 denotes hair placode
T21738 1583-1605 GO:0060789 denotes hair placode formation
T21739 1664-1673 UBERON:0000922 denotes embryonic
T21740 1674-1683 UBERON:0007376 denotes epidermis
T21741 1699-1707 UBERON:0013623 denotes footpads
T21742 1724-1728 UBERON:0001037 denotes hair
T21743 1844-1848 NCBITaxon:10088 denotes mice
T21744 1878-1881 PR:000009454 denotes K14
T21745 1902-1906 NCBITaxon:10088 denotes mice
T21746 1907-1917 GO:0010467 denotes expressing
T21747 1925-1934 PR:000002198 denotes β-catenin
T21748 1945-1952 GO:0065007 denotes control
T21749 1956-1959 PR:000009454 denotes K14
T21750 1960-1968 SO:0000167 denotes promoter
T21751 1978-1981 PR:000009454 denotes K14
T21752 1982-1986 PR:000009751 denotes Lef1
T21753 1998-2002 NCBITaxon:10088 denotes mice
T21754 2034-2038 NCBITaxon:10088 denotes mice
T21755 2073-2076 PR:000009454 denotes K14
T21756 2077-2081 PR:000009751 denotes Lef1
T21757 2082-2086 NCBITaxon:10088 denotes mice
T21758 2096-2099 PR:000009454 denotes K14
T21759 2120-2124 NCBITaxon:10088 denotes mice
T21760 2153-2157 NCBITaxon:10088 denotes mice
T21761 2218-2221 PR:000009454 denotes K14
T21762 2237-2240 PR:000009454 denotes K14
T21763 2261-2265 NCBITaxon:10088 denotes mice
T21764 2290-2294 NCBITaxon:10088 denotes mice
T21765 2320-2329 UBERON:0010166 denotes hair coat
T21766 2371-2376 UBERON:0001037 denotes hairs
T21767 2406-2409 PR:000009454 denotes K14
T21768 2410-2414 PR:000009751 denotes Lef1
T21769 2415-2419 NCBITaxon:10088 denotes mice
T21770 2432-2435 PR:000009454 denotes K14
T21771 2445-2449 NCBITaxon:10088 denotes mice
T21772 2451-2460 UBERON:0000922 denotes embryonic
T21773 2451-2460 _FRAGMENT denotes embryonic
T21774 2475-2488 GO:0048598 denotes morphogenesis
T21775 2461-2474 UBERON:0002073 denotes hair follicle
T21776 2461-2488 GO:0031069 denotes hair follicle morphogenesis
T21777 2544-2551 GO:0007567 denotes natally
T21778 2675-2678 PR:000009454 denotes K14
T21779 2679-2687 SO:0000167 denotes promoter
T21780 2720-2730 GO:0010467 denotes expression
T21781 2822-2832 GO:0010467 denotes expression
T21782 2836-2844 SO:0000167 denotes promoter
T21783 2845-2854 SO:0000902 denotes transgene
T21784 2879-2883 NCBITaxon:10088 denotes mice
T21785 2945-2961 SO:0000366 denotes integration site
T21786 2969-2978 SO:0000902 denotes transgene
T21787 2986-2991 NCBITaxon:10088 denotes mouse
T21788 2992-2998 SO:0001026 denotes genome
T21789 3017-3040 SO:0000366 denotes location of integration
T21790 3088-3097 SO:0000902 denotes transgene
T21791 3185-3198 GO:0009790 denotes embryogenesis
T21792 3235-3245 GO:0010467 denotes expression
T21793 3253-3256 PR:000009454 denotes K14
T21794 3266-3275 SO:0000902 denotes transgene
T21795 3302-3310 SO:0000167 denotes promoter
T21796 3377-3380 PR:000009454 denotes K14
T21797 3396-3400 NCBITaxon:10088 denotes mice
T21798 3429-3432 PR:000009454 denotes K14
T21799 3464-3467 PR:000004122 denotes Apc
T21800 3468-3472 SO:0000704 denotes gene
T21801 3540-3553 UBERON:0002073 denotes hair follicle
T21802 3540-3566 GO:0031069 denotes hair follicle morphgenesis
T21803 3650-3660 GO:0010467 denotes expression
T21804 3664-3673 SO:0000902 denotes transgene
T21805 3693-3707 _FRAGMENT denotes basal cells of
T21806 3712-3721 CL:0002187 denotes epidermis
T21807 3699-3707 _FRAGMENT denotes cells of
T21808 3730-3751 CL:0002561 denotes ORS of hair follicles
T21809 3712-3721 UBERON:0007376 denotes epidermis
T21810 3730-3751 UBERON:0005942 denotes ORS of hair follicles
T21811 3763-3766 PR:000009454 denotes K14
T21812 3767-3775 SO:0000167 denotes promoter
T21813 3791-3801 GO:0010467 denotes expression
T21814 3805-3814 SO:0000902 denotes transgene
T21815 3849-3852 PR:000009454 denotes K14
T21816 3853-3863 GO:0010467 denotes expressing
T21817 3923-3926 PR:000009454 denotes K14
T21818 3952-3955 PR:000004122 denotes Apc
T21819 3972-3975 PR:000004122 denotes Apc
T21820 3997-4000 PR:000009454 denotes K14
T21821 4001-4009 SO:0000167 denotes promoter
T21822 4045-4056 UBERON:0000119 denotes cell layers
T21823 4079-4082 PR:000009454 denotes K14
T21824 4083-4091 SO:0000167 denotes promoter
T21825 4142-4162 UBERON:0010402 denotes suprabasal epidermis
T21826 4178-4188 UBERON:0000483 denotes epithelium
T21827 4196-4209 UBERON:0002073 denotes hair follicle
T21828 4228-4237 PR:000002198 denotes β-catenin
T21829 4365-4374 PR:000002198 denotes β-catenin
T21830 4375-4385 GO:0010467 denotes expression
T21831 4396-4398 PR:000009450 denotes K1
T21832 4443-4448 GO:0007567 denotes natal
T21833 4505-4508 PR:000004122 denotes Apc
T21834 4540-4549 PR:000002198 denotes β-catenin
T21835 4568-4571 PR:000009454 denotes K14
T21836 4572-4582 GO:0010467 denotes expressing
T21837 4605-4614 PR:000002198 denotes β-catenin
T21838 4615-4625 GO:0010467 denotes expression
T21839 4642-4665 GO:0001709 denotes cell fate determination
T21840 4689-4700 CL:0000646 denotes basal cells
T21841 4785-4788 PR:000004122 denotes Apc
T21842 4848-4857 PR:000002198 denotes β-catenin
T21843 4951-4955 NCBITaxon:10088 denotes mice
T21844 4989-4993 NCBITaxon:10088 denotes mice
T21845 5067-5080 UBERON:0002073 denotes hair follicle
T21846 5067-5094 GO:0031069 denotes hair follicle morphogenesis
T21847 5096-5099 PR:000009454 denotes K14
T21848 5115-5118 PR:000004122 denotes Apc
T21849 5148-5158 UBERON:0008281 denotes tooth buds
T21850 5170-5184 UBERON:0002073 denotes hair follicles
T21851 5251-5261 UBERON:0000483 denotes epithelium
T21852 5266-5276 UBERON:0003104 denotes mesenchyme
T21853 5322-5332 UBERON:0008281 denotes tooth buds
T21854 5342-5349 NCBITaxon:33208 denotes animals
T21855 5353-5363 GO:0010467 denotes expressing
T21856 5364-5368 PR:000009751 denotes Lef1
T21857 5415-5420 GO:0007567 denotes birth
T21858 5447-5450 PR:000004122 denotes Apc
T21859 5481-5490 UBERON:0000922 denotes embryonic
T21860 5481-5490 _FRAGMENT denotes embryonic
T21861 5497-5508 GO:0009790 denotes development
T21862 5491-5496 UBERON:0001091 denotes tooth
T21863 5540-5543 PR:000014841 denotes Shh
T21864 5544-5554 GO:0010467 denotes expression
T21865 5564-5573 UBERON:0000922 denotes embryonic
T21866 5574-5589 UBERON:0002424 denotes oral epithelium
T21867 5652-5662 UBERON:0008281 denotes tooth buds
T21868 5717-5722 UBERON:0001091 denotes teeth
T21869 5757-5761 NCBITaxon:10088 denotes mice
T21870 5771-5776 UBERON:0001091 denotes tooth
T21871 5802-5807 UBERON:0001091 denotes tooth
T21872 5841-5845 NCBITaxon:10088 denotes mice
T21873 5890-5894 NCBITaxon:10088 denotes mice
T21874 5903-5910 GO:0007567 denotes natally
T21875 5938-5942 NCBITaxon:10088 denotes mice
T21876 6020-6026 UBERON:0000062 denotes organs
T21877 6033-6037 NCBITaxon:10088 denotes mice
T21878 6180-6184 CHEBI:33290 denotes food
T21879 6194-6201 UBERON:0000945 denotes stomach
T21880 6240-6244 GO:0016265 denotes died
T21881 6372-6377 UBERON:0001091 denotes teeth
T21882 6457-6463 GO:0001967 denotes nursed
T21883 6508-6513 UBERON:0001091 denotes teeth
T21884 6542-6547 GO:0016265 denotes death
T21885 6603-6608 UBERON:0001091 denotes teeth
T21886 6613-6627 UBERON:0001911 denotes mammary glands
T21887 6650-6654 NCBITaxon:10088 denotes mice
T21888 6668-6672 PR:000009751 denotes Lef1
T21889 6689-6699 GO:0010467 denotes expressing
T21890 6700-6704 PR:000006499 denotes Dkk1
T21891 6823-6832 UBERON:0008281 denotes tooth bud
T21892 6872-6877 UBERON:0001091 denotes teeth
T21893 6882-6886 NCBITaxon:10088 denotes mice
T21894 6921-6925 UBERON:0000104 denotes life
T21895 6985-6994 PR:000002198 denotes β-catenin
T21896 7021-7026 UBERON:0001091 denotes tooth
R5936 T21722 T21721 _lexicallyChainedTo stem cells,specification of
R5937 T21723 T21721 _lexicallyChainedTo ectodermal,specification of
R5938 T21724 T21723 _lexicallyChainedTo cells,ectodermal
R5939 T21727 T21726 _lexicallyChainedTo stem cells,embryonic
R5940 T21728 T21723 _lexicallyChainedTo cells,ectodermal
R5941 T21774 T21773 _lexicallyChainedTo morphogenesis,embryonic
R5942 T21806 T21805 _lexicallyChainedTo epidermis,basal cells of
R5943 T21808 T21807 _lexicallyChainedTo ORS of hair follicles,cells of
R5944 T21861 T21860 _lexicallyChainedTo development,embryonic

craft-sa-dev

Id Subject Object Predicate Lexical cue
T22183 0-3 NN denotes Apc
T22184 22-35 NN denotes Morphogenesis
T22185 4-7 CC denotes and
T22186 8-12 NN denotes Hair
T22187 13-21 NN denotes Follicle
T22188 35-308 sentence denotes Current models of hair follicle development suggest that the establishment of a regular array of placodes in the surface epithelium in response to the first dermal message is achieved through the competing activities of molecules that promote or repress placode fate [24].
T22189 36-43 JJ denotes Current
T22190 44-50 NNS denotes models
T22191 80-87 VBP denotes suggest
T22192 51-53 IN denotes of
T22193 54-58 NN denotes hair
T22194 59-67 NN denotes follicle
T22195 68-79 NN denotes development
T22196 88-92 IN denotes that
T22197 211-219 VBN denotes achieved
T22198 93-96 DT denotes the
T22199 97-110 NN denotes establishment
T22200 111-113 IN denotes of
T22201 114-115 DT denotes a
T22202 124-129 NN denotes array
T22203 116-123 JJ denotes regular
T22204 130-132 IN denotes of
T22205 133-141 NNS denotes placodes
T22206 142-144 IN denotes in
T22207 145-148 DT denotes the
T22208 157-167 NN denotes epithelium
T22209 149-156 NN denotes surface
T22210 168-170 IN denotes in
T22211 171-179 NN denotes response
T22212 180-182 IN denotes to
T22213 183-186 DT denotes the
T22214 200-207 NN denotes message
T22215 187-192 JJ denotes first
T22216 193-199 JJ denotes dermal
T22217 208-210 VBZ denotes is
T22218 220-227 IN denotes through
T22219 228-231 DT denotes the
T22220 242-252 NNS denotes activities
T22221 232-241 VBG denotes competing
T22222 253-255 IN denotes of
T22223 256-265 NNS denotes molecules
T22224 266-270 WDT denotes that
T22225 271-278 VBP denotes promote
T22226 279-281 CC denotes or
T22227 282-289 VBP denotes repress
T22228 290-297 NN denotes placode
T22229 298-302 NN denotes fate
T22230 303-304 -LRB- denotes [
T22231 304-306 CD denotes 24
T22232 306-307 -RRB- denotes ]
T22233 307-308 . denotes .
T22234 308-455 sentence denotes There is accumulating evidence that activation of the Wnt signaling pathway in the dermis may be involved in establishing the first dermal signal.
T22235 309-314 EX denotes There
T22236 315-317 VBZ denotes is
T22237 318-330 VBG denotes accumulating
T22238 331-339 NN denotes evidence
T22239 340-344 IN denotes that
T22240 406-414 VBN denotes involved
T22241 345-355 NN denotes activation
T22242 356-358 IN denotes of
T22243 359-362 DT denotes the
T22244 377-384 NN denotes pathway
T22245 363-366 NN denotes Wnt
T22246 367-376 NN denotes signaling
T22247 385-387 IN denotes in
T22248 388-391 DT denotes the
T22249 392-398 NN denotes dermis
T22250 399-402 MD denotes may
T22251 403-405 VB denotes be
T22252 415-417 IN denotes in
T22253 418-430 VBG denotes establishing
T22254 431-434 DT denotes the
T22255 448-454 NN denotes signal
T22256 435-440 JJ denotes first
T22257 441-447 JJ denotes dermal
T22258 454-455 . denotes .
T22259 455-693 sentence denotes Experimental activation of epithelial β-catenin signaling (by expression of N-terminal–truncated, constitutively stabilized forms of β-catenin or ectopic expression of Lef1) induces ectopic follicles in both mouse and chick skin [25–27].
T22260 456-468 JJ denotes Experimental
T22261 469-479 NN denotes activation
T22262 630-637 VBZ denotes induces
T22263 480-482 IN denotes of
T22264 483-493 JJ denotes epithelial
T22265 504-513 NN denotes signaling
T22266 494-495 NN denotes β
T22267 496-503 NN denotes catenin
T22268 495-496 HYPH denotes -
T22269 514-515 -LRB- denotes (
T22270 515-517 IN denotes by
T22271 518-528 NN denotes expression
T22272 529-531 IN denotes of
T22273 532-533 NN denotes N
T22274 534-542 NN denotes terminal
T22275 533-534 HYPH denotes -
T22276 543-552 JJ denotes truncated
T22277 542-543 HYPH denotes –
T22278 580-585 NNS denotes forms
T22279 552-554 , denotes ,
T22280 554-568 RB denotes constitutively
T22281 569-579 VBN denotes stabilized
T22282 586-588 IN denotes of
T22283 589-590 NN denotes β
T22284 591-598 NN denotes catenin
T22285 590-591 HYPH denotes -
T22286 599-601 CC denotes or
T22287 602-609 JJ denotes ectopic
T22288 610-620 NN denotes expression
T22289 621-623 IN denotes of
T22290 624-628 NN denotes Lef1
T22291 628-629 -RRB- denotes )
T22292 638-645 JJ denotes ectopic
T22293 646-655 NNS denotes follicles
T22294 656-658 IN denotes in
T22295 659-663 CC denotes both
T22296 664-669 NN denotes mouse
T22297 680-684 NN denotes skin
T22298 670-673 CC denotes and
T22299 674-679 NN denotes chick
T22300 685-686 -LRB- denotes [
T22301 686-688 CD denotes 25
T22302 688-689 SYM denotes –
T22303 689-691 CD denotes 27
T22304 691-692 -RRB- denotes ]
T22305 692-693 . denotes .
T22306 693-933 sentence denotes Conversely, down-regulation of β-catenin signaling (through Lef1 knock-out, ectopic expression of Wnt inhibitor Dkk1 or conditional deletion of β-catenin in epidermis) results in loss of vibrissae and some pelage follicles in mice [28–30].
T22307 694-704 RB denotes Conversely
T22308 862-869 VBZ denotes results
T22309 704-706 , denotes ,
T22310 706-710 JJ denotes down
T22311 711-721 NN denotes regulation
T22312 710-711 HYPH denotes -
T22313 722-724 IN denotes of
T22314 725-726 NN denotes β
T22315 727-734 NN denotes catenin
T22316 726-727 HYPH denotes -
T22317 735-744 NN denotes signaling
T22318 745-746 -LRB- denotes (
T22319 746-753 IN denotes through
T22320 754-758 NN denotes Lef1
T22321 759-764 VB denotes knock
T22322 778-788 NN denotes expression
T22323 764-765 HYPH denotes -
T22324 765-768 RP denotes out
T22325 768-770 , denotes ,
T22326 770-777 JJ denotes ectopic
T22327 789-791 IN denotes of
T22328 792-795 NN denotes Wnt
T22329 796-805 NN denotes inhibitor
T22330 806-810 NN denotes Dkk1
T22331 811-813 CC denotes or
T22332 814-825 JJ denotes conditional
T22333 826-834 NN denotes deletion
T22334 835-837 IN denotes of
T22335 838-839 NN denotes β
T22336 840-847 NN denotes catenin
T22337 839-840 HYPH denotes -
T22338 848-850 IN denotes in
T22339 851-860 NN denotes epidermis
T22340 860-861 -RRB- denotes )
T22341 870-872 IN denotes in
T22342 873-877 NN denotes loss
T22343 878-880 IN denotes of
T22344 881-890 NNS denotes vibrissae
T22345 891-894 CC denotes and
T22346 895-899 DT denotes some
T22347 907-916 NNS denotes follicles
T22348 900-906 NN denotes pelage
T22349 917-919 IN denotes in
T22350 920-924 NNS denotes mice
T22351 925-926 -LRB- denotes [
T22352 926-928 CD denotes 28
T22353 928-929 SYM denotes –
T22354 929-931 CD denotes 30
T22355 931-932 -RRB- denotes ]
T22356 932-933 . denotes .
T22357 933-1427 sentence denotes Our finding that K14-driven Apc loss in embryonic ectoderm resulted in irregularly spaced and often tightly clustered abnormal hair placode initiation and follicle morphogenesis (Figures 4F, 5B, 5D, and 5F) as well as in the development of multiple tooth buds (Figure 4O and 4P), is in line with the effects seen in activation of epithelial β-catenin signaling during placode formation, indicating the role of Apc in specification of embryonic ectodermal stem cells to produce a hair follicle.
T22358 934-937 PRP$ denotes Our
T22359 938-945 NN denotes finding
T22360 1214-1216 VBZ denotes is
T22361 946-950 IN denotes that
T22362 993-1001 VBD denotes resulted
T22363 951-954 NN denotes K14
T22364 955-961 VBN denotes driven
T22365 954-955 HYPH denotes -
T22366 966-970 NN denotes loss
T22367 962-965 NN denotes Apc
T22368 971-973 IN denotes in
T22369 974-983 JJ denotes embryonic
T22370 984-992 NN denotes ectoderm
T22371 1002-1004 IN denotes in
T22372 1005-1016 RB denotes irregularly
T22373 1017-1023 VBN denotes spaced
T22374 1074-1084 NN denotes initiation
T22375 1024-1027 CC denotes and
T22376 1028-1033 RB denotes often
T22377 1042-1051 VBN denotes clustered
T22378 1034-1041 RB denotes tightly
T22379 1052-1060 JJ denotes abnormal
T22380 1061-1065 NN denotes hair
T22381 1066-1073 NN denotes placode
T22382 1085-1088 CC denotes and
T22383 1089-1097 NN denotes follicle
T22384 1098-1111 NN denotes morphogenesis
T22385 1112-1113 -LRB- denotes (
T22386 1121-1123 NN denotes 4F
T22387 1113-1120 NNS denotes Figures
T22388 1123-1125 , denotes ,
T22389 1125-1127 NN denotes 5B
T22390 1127-1129 , denotes ,
T22391 1129-1131 NN denotes 5D
T22392 1131-1133 , denotes ,
T22393 1133-1136 CC denotes and
T22394 1137-1139 NN denotes 5F
T22395 1139-1140 -RRB- denotes )
T22396 1141-1143 RB denotes as
T22397 1149-1151 IN denotes as
T22398 1144-1148 RB denotes well
T22399 1152-1154 IN denotes in
T22400 1155-1158 DT denotes the
T22401 1159-1170 NN denotes development
T22402 1171-1173 IN denotes of
T22403 1174-1182 JJ denotes multiple
T22404 1189-1193 NNS denotes buds
T22405 1183-1188 NN denotes tooth
T22406 1194-1195 -LRB- denotes (
T22407 1202-1204 NN denotes 4O
T22408 1195-1201 NN denotes Figure
T22409 1205-1208 CC denotes and
T22410 1209-1211 NN denotes 4P
T22411 1211-1212 -RRB- denotes )
T22412 1212-1214 , denotes ,
T22413 1217-1219 IN denotes in
T22414 1220-1224 NN denotes line
T22415 1225-1229 IN denotes with
T22416 1230-1233 DT denotes the
T22417 1234-1241 NNS denotes effects
T22418 1242-1246 VBN denotes seen
T22419 1247-1249 IN denotes in
T22420 1250-1260 NN denotes activation
T22421 1261-1263 IN denotes of
T22422 1264-1274 JJ denotes epithelial
T22423 1285-1294 NN denotes signaling
T22424 1275-1276 NN denotes β
T22425 1277-1284 NN denotes catenin
T22426 1276-1277 HYPH denotes -
T22427 1295-1301 IN denotes during
T22428 1302-1309 NN denotes placode
T22429 1310-1319 NN denotes formation
T22430 1319-1321 , denotes ,
T22431 1321-1331 VBG denotes indicating
T22432 1332-1335 DT denotes the
T22433 1336-1340 NN denotes role
T22434 1341-1343 IN denotes of
T22435 1344-1347 NN denotes Apc
T22436 1348-1350 IN denotes in
T22437 1351-1364 NN denotes specification
T22438 1365-1367 IN denotes of
T22439 1368-1377 JJ denotes embryonic
T22440 1394-1399 NNS denotes cells
T22441 1378-1388 JJ denotes ectodermal
T22442 1389-1393 NN denotes stem
T22443 1400-1402 TO denotes to
T22444 1403-1410 VB denotes produce
T22445 1411-1412 DT denotes a
T22446 1418-1426 NN denotes follicle
T22447 1413-1417 NN denotes hair
T22448 1426-1427 . denotes .
T22449 1427-1761 sentence denotes Given the role of Apc in down-regulation of β-catenin, loss of Apc would inevitably lead to altered expression of β-catenin in ectodermal cells during the hair placode formation, giving rise to aberrant follicular growth throughout the embryonic epidermis, including the footpads, where normally hairless (Figure 5B, 5D, 5F, and 5H).
T22450 1428-1433 VBN denotes Given
T22451 1512-1516 VB denotes lead
T22452 1434-1437 DT denotes the
T22453 1438-1442 NN denotes role
T22454 1443-1445 IN denotes of
T22455 1446-1449 NN denotes Apc
T22456 1450-1452 IN denotes in
T22457 1453-1457 RB denotes down
T22458 1458-1468 NN denotes regulation
T22459 1457-1458 HYPH denotes -
T22460 1469-1471 IN denotes of
T22461 1472-1473 NN denotes β
T22462 1474-1481 NN denotes catenin
T22463 1473-1474 HYPH denotes -
T22464 1481-1483 , denotes ,
T22465 1483-1487 NN denotes loss
T22466 1488-1490 IN denotes of
T22467 1491-1494 NNP denotes Apc
T22468 1495-1500 MD denotes would
T22469 1501-1511 RB denotes inevitably
T22470 1517-1519 IN denotes to
T22471 1520-1527 JJ denotes altered
T22472 1528-1538 NN denotes expression
T22473 1539-1541 IN denotes of
T22474 1542-1543 NN denotes β
T22475 1544-1551 NN denotes catenin
T22476 1543-1544 HYPH denotes -
T22477 1552-1554 IN denotes in
T22478 1555-1565 JJ denotes ectodermal
T22479 1566-1571 NNS denotes cells
T22480 1572-1578 IN denotes during
T22481 1579-1582 DT denotes the
T22482 1596-1605 NN denotes formation
T22483 1583-1587 NN denotes hair
T22484 1588-1595 NN denotes placode
T22485 1605-1607 , denotes ,
T22486 1607-1613 VBG denotes giving
T22487 1614-1618 NN denotes rise
T22488 1619-1621 IN denotes to
T22489 1622-1630 JJ denotes aberrant
T22490 1642-1648 NN denotes growth
T22491 1631-1641 JJ denotes follicular
T22492 1649-1659 IN denotes throughout
T22493 1660-1663 DT denotes the
T22494 1674-1683 NN denotes epidermis
T22495 1664-1673 JJ denotes embryonic
T22496 1683-1685 , denotes ,
T22497 1685-1694 VBG denotes including
T22498 1695-1698 DT denotes the
T22499 1699-1707 NNS denotes footpads
T22500 1707-1709 , denotes ,
T22501 1709-1714 WRB denotes where
T22502 1724-1732 JJ denotes hairless
T22503 1715-1723 RB denotes normally
T22504 1733-1734 -LRB- denotes (
T22505 1741-1743 NN denotes 5B
T22506 1734-1740 NN denotes Figure
T22507 1743-1745 , denotes ,
T22508 1745-1747 NN denotes 5D
T22509 1747-1749 , denotes ,
T22510 1749-1751 NN denotes 5F
T22511 1751-1753 , denotes ,
T22512 1753-1756 CC denotes and
T22513 1757-1759 NN denotes 5H
T22514 1759-1760 -RRB- denotes )
T22515 1760-1761 . denotes .
T22516 1761-2008 sentence denotes Of interest are the phenotypic similarities and differences between our KA mutant mice and the previously described K14-ΔN87βcat transgenic mice expressing stable β-catenin under the control of K14 promoter [25] and K14-Lef1 transgenic mice [27].
T22517 1762-1764 IN denotes Of
T22518 1774-1777 VBP denotes are
T22519 1765-1773 NN denotes interest
T22520 1778-1781 DT denotes the
T22521 1793-1805 NNS denotes similarities
T22522 1782-1792 JJ denotes phenotypic
T22523 1806-1809 CC denotes and
T22524 1810-1821 NNS denotes differences
T22525 1822-1829 IN denotes between
T22526 1830-1833 PRP$ denotes our
T22527 1844-1848 NNS denotes mice
T22528 1834-1836 NN denotes KA
T22529 1837-1843 JJ denotes mutant
T22530 1849-1852 CC denotes and
T22531 1853-1856 DT denotes the
T22532 1902-1906 NNS denotes mice
T22533 1857-1867 RB denotes previously
T22534 1868-1877 VBN denotes described
T22535 1878-1881 NN denotes K14
T22536 1882-1890 NN denotes ΔN87βcat
T22537 1881-1882 HYPH denotes -
T22538 1891-1901 JJ denotes transgenic
T22539 1907-1917 VBG denotes expressing
T22540 1918-1924 JJ denotes stable
T22541 1927-1934 NN denotes catenin
T22542 1925-1926 NN denotes β
T22543 1926-1927 HYPH denotes -
T22544 1935-1940 IN denotes under
T22545 1941-1944 DT denotes the
T22546 1945-1952 NN denotes control
T22547 1953-1955 IN denotes of
T22548 1956-1959 NN denotes K14
T22549 1960-1968 NN denotes promoter
T22550 1969-1970 -LRB- denotes [
T22551 1970-1972 CD denotes 25
T22552 1972-1973 -RRB- denotes ]
T22553 1974-1977 CC denotes and
T22554 1978-1981 NN denotes K14
T22555 1982-1986 NN denotes Lef1
T22556 1981-1982 HYPH denotes -
T22557 1998-2002 NNS denotes mice
T22558 1987-1997 JJ denotes transgenic
T22559 2003-2004 -LRB- denotes [
T22560 2004-2006 CD denotes 27
T22561 2006-2007 -RRB- denotes ]
T22562 2007-2008 . denotes .
T22563 2008-2125 sentence denotes Surprisingly, our mutant mice shared more similarities with the K14-Lef1 mice than the K14-ΔN87βcat transgenic mice.
T22564 2009-2021 RB denotes Surprisingly
T22565 2039-2045 VBD denotes shared
T22566 2021-2023 , denotes ,
T22567 2023-2026 PRP$ denotes our
T22568 2034-2038 NNS denotes mice
T22569 2027-2033 JJ denotes mutant
T22570 2046-2050 JJR denotes more
T22571 2051-2063 NNS denotes similarities
T22572 2064-2068 IN denotes with
T22573 2069-2072 DT denotes the
T22574 2082-2086 NNS denotes mice
T22575 2073-2076 NN denotes K14
T22576 2077-2081 NN denotes Lef1
T22577 2076-2077 HYPH denotes -
T22578 2087-2091 IN denotes than
T22579 2092-2095 DT denotes the
T22580 2120-2124 NNS denotes mice
T22581 2096-2099 NN denotes K14
T22582 2100-2108 NN denotes ΔN87βcat
T22583 2099-2100 HYPH denotes -
T22584 2109-2119 JJ denotes transgenic
T22585 2124-2125 . denotes .
T22586 2125-2266 sentence denotes For example, the KA mutant mice displayed the disoriented and short, curly whiskers seen in K14-Lef1but not in K14-ΔN87βcat transgenic mice.
T22587 2126-2129 IN denotes For
T22588 2158-2167 VBD denotes displayed
T22589 2130-2137 NN denotes example
T22590 2137-2139 , denotes ,
T22591 2139-2142 DT denotes the
T22592 2153-2157 NNS denotes mice
T22593 2143-2145 NN denotes KA
T22594 2146-2152 JJ denotes mutant
T22595 2168-2171 DT denotes the
T22596 2201-2209 NNS denotes whiskers
T22597 2172-2183 JJ denotes disoriented
T22598 2184-2187 CC denotes and
T22599 2188-2193 JJ denotes short
T22600 2193-2195 , denotes ,
T22601 2195-2200 JJ denotes curly
T22602 2210-2214 VBN denotes seen
T22603 2215-2217 IN denotes in
T22604 2218-2221 NN denotes K14
T22605 2222-2229 NN denotes Lef1but
T22606 2221-2222 HYPH denotes -
T22607 2230-2233 RB denotes not
T22608 2234-2236 IN denotes in
T22609 2237-2240 NN denotes K14
T22610 2241-2249 NN denotes ΔN87βcat
T22611 2240-2241 HYPH denotes -
T22612 2261-2265 NNS denotes mice
T22613 2250-2260 JJ denotes transgenic
T22614 2265-2266 . denotes .
T22615 2266-2552 sentence denotes In addition, KA mutant mice displayed a disorganized hair coat beginning with the emergence of neonatal hairs, similar to that observed in K14-Lef1 mice, whereas in K14-ΔN87βcat mice, embryonic hair follicle morphogenesis was unaffected and other skin changes only emerged postnatally.
T22616 2267-2269 IN denotes In
T22617 2295-2304 VBD denotes displayed
T22618 2270-2278 NN denotes addition
T22619 2278-2280 , denotes ,
T22620 2280-2282 NN denotes KA
T22621 2290-2294 NNS denotes mice
T22622 2283-2289 JJ denotes mutant
T22623 2305-2306 DT denotes a
T22624 2325-2329 NN denotes coat
T22625 2307-2319 JJ denotes disorganized
T22626 2320-2324 NN denotes hair
T22627 2330-2339 VBG denotes beginning
T22628 2340-2344 IN denotes with
T22629 2345-2348 DT denotes the
T22630 2349-2358 NN denotes emergence
T22631 2359-2361 IN denotes of
T22632 2362-2370 JJ denotes neonatal
T22633 2371-2376 NNS denotes hairs
T22634 2376-2378 , denotes ,
T22635 2378-2385 JJ denotes similar
T22636 2386-2388 IN denotes to
T22637 2389-2393 DT denotes that
T22638 2394-2402 VBN denotes observed
T22639 2403-2405 IN denotes in
T22640 2406-2409 NN denotes K14
T22641 2410-2414 NN denotes Lef1
T22642 2409-2410 HYPH denotes -
T22643 2415-2419 NNS denotes mice
T22644 2419-2421 , denotes ,
T22645 2421-2428 IN denotes whereas
T22646 2489-2492 VBD denotes was
T22647 2429-2431 IN denotes in
T22648 2432-2435 NN denotes K14
T22649 2436-2444 NN denotes ΔN87βcat
T22650 2435-2436 HYPH denotes -
T22651 2445-2449 NNS denotes mice
T22652 2449-2451 , denotes ,
T22653 2451-2460 JJ denotes embryonic
T22654 2475-2488 NN denotes morphogenesis
T22655 2461-2465 NN denotes hair
T22656 2466-2474 NN denotes follicle
T22657 2493-2503 JJ denotes unaffected
T22658 2504-2507 CC denotes and
T22659 2508-2513 JJ denotes other
T22660 2519-2526 NNS denotes changes
T22661 2514-2518 NN denotes skin
T22662 2532-2539 VBD denotes emerged
T22663 2527-2531 RB denotes only
T22664 2540-2551 RB denotes postnatally
T22665 2551-2552 . denotes .
T22666 2552-2657 sentence denotes The reason for this difference could be attributed to one or all of three possible contributing factors.
T22667 2553-2556 DT denotes The
T22668 2557-2563 NN denotes reason
T22669 2593-2603 VBN denotes attributed
T22670 2564-2567 IN denotes for
T22671 2568-2572 DT denotes this
T22672 2573-2583 NN denotes difference
T22673 2584-2589 MD denotes could
T22674 2590-2592 VB denotes be
T22675 2604-2606 IN denotes to
T22676 2607-2610 CD denotes one
T22677 2611-2613 CC denotes or
T22678 2614-2617 DT denotes all
T22679 2618-2620 IN denotes of
T22680 2621-2626 CD denotes three
T22681 2649-2656 NNS denotes factors
T22682 2627-2635 JJ denotes possible
T22683 2636-2648 VBG denotes contributing
T22684 2656-2657 . denotes .
T22685 2657-2884 sentence denotes (1) Although the K14 promoter itself is known to initiate the expression at E9.5 and elevated dramatically by E13.5–E14.5 [19,31], many factors could influence the expression of promoter/transgene construct in transgenic mice.
T22686 2658-2659 -LRB- denotes (
T22687 2659-2660 LS denotes 1
T22688 2808-2817 VB denotes influence
T22689 2660-2661 -RRB- denotes )
T22690 2662-2670 IN denotes Although
T22691 2698-2703 VBN denotes known
T22692 2671-2674 DT denotes the
T22693 2679-2687 NN denotes promoter
T22694 2675-2678 NN denotes K14
T22695 2688-2694 PRP denotes itself
T22696 2695-2697 VBZ denotes is
T22697 2704-2706 TO denotes to
T22698 2707-2715 VB denotes initiate
T22699 2716-2719 DT denotes the
T22700 2720-2730 NN denotes expression
T22701 2731-2733 IN denotes at
T22702 2734-2738 NN denotes E9.5
T22703 2739-2742 CC denotes and
T22704 2743-2751 VBN denotes elevated
T22705 2752-2764 RB denotes dramatically
T22706 2765-2767 IN denotes by
T22707 2768-2773 NN denotes E13.5
T22708 2773-2774 SYM denotes –
T22709 2774-2779 NN denotes E14.5
T22710 2780-2781 -LRB- denotes [
T22711 2784-2786 CD denotes 31
T22712 2781-2783 CD denotes 19
T22713 2783-2784 , denotes ,
T22714 2786-2787 -RRB- denotes ]
T22715 2787-2789 , denotes ,
T22716 2789-2793 JJ denotes many
T22717 2794-2801 NNS denotes factors
T22718 2802-2807 MD denotes could
T22719 2818-2821 DT denotes the
T22720 2822-2832 NN denotes expression
T22721 2833-2835 IN denotes of
T22722 2836-2844 NN denotes promoter
T22723 2845-2854 NN denotes transgene
T22724 2844-2845 HYPH denotes /
T22725 2855-2864 NN denotes construct
T22726 2865-2867 IN denotes in
T22727 2868-2878 JJ denotes transgenic
T22728 2879-2883 NNS denotes mice
T22729 2883-2884 . denotes .
T22730 2884-2999 sentence denotes One of the most important considerations has to do with the integration site of the transgene in the mouse genome.
T22731 2885-2888 CD denotes One
T22732 2926-2929 VBZ denotes has
T22733 2889-2891 IN denotes of
T22734 2892-2895 DT denotes the
T22735 2911-2925 NNS denotes considerations
T22736 2896-2900 RBS denotes most
T22737 2901-2910 JJ denotes important
T22738 2930-2932 TO denotes to
T22739 2933-2935 VB denotes do
T22740 2936-2940 IN denotes with
T22741 2941-2944 DT denotes the
T22742 2957-2961 NN denotes site
T22743 2945-2956 NN denotes integration
T22744 2962-2964 IN denotes of
T22745 2965-2968 DT denotes the
T22746 2969-2978 NN denotes transgene
T22747 2979-2981 IN denotes in
T22748 2982-2985 DT denotes the
T22749 2992-2998 NN denotes genome
T22750 2986-2991 NN denotes mouse
T22751 2998-2999 . denotes .
T22752 2999-3122 sentence denotes Depending on the location of integration, the transcriptional activity of even the same transgene could vary considerably.
T22753 3000-3009 VBG denotes Depending
T22754 3104-3108 VB denotes vary
T22755 3010-3012 IN denotes on
T22756 3013-3016 DT denotes the
T22757 3017-3025 NN denotes location
T22758 3026-3028 IN denotes of
T22759 3029-3040 NN denotes integration
T22760 3040-3042 , denotes ,
T22761 3042-3045 DT denotes the
T22762 3062-3070 NN denotes activity
T22763 3046-3061 JJ denotes transcriptional
T22764 3071-3073 IN denotes of
T22765 3074-3078 RB denotes even
T22766 3088-3097 NN denotes transgene
T22767 3079-3082 DT denotes the
T22768 3083-3087 JJ denotes same
T22769 3098-3103 MD denotes could
T22770 3109-3121 RB denotes considerably
T22771 3121-3122 . denotes .
T22772 3122-3311 sentence denotes It is possible that the apparent lack of ΔN87βcat function in embryogenesis could be due to the delayed or weak expression of the K14-ΔN87βcat transgene compared to the intrinsic promoter.
T22773 3123-3125 PRP denotes It
T22774 3126-3128 VBZ denotes is
T22775 3129-3137 JJ denotes possible
T22776 3138-3142 IN denotes that
T22777 3205-3207 VB denotes be
T22778 3143-3146 DT denotes the
T22779 3156-3160 NN denotes lack
T22780 3147-3155 JJ denotes apparent
T22781 3161-3163 IN denotes of
T22782 3164-3172 NN denotes ΔN87βcat
T22783 3173-3181 NN denotes function
T22784 3182-3184 IN denotes in
T22785 3185-3198 NN denotes embryogenesis
T22786 3199-3204 MD denotes could
T22787 3208-3211 IN denotes due
T22788 3212-3214 IN denotes to
T22789 3215-3218 DT denotes the
T22790 3235-3245 NN denotes expression
T22791 3219-3226 VBN denotes delayed
T22792 3227-3229 CC denotes or
T22793 3230-3234 JJ denotes weak
T22794 3246-3248 IN denotes of
T22795 3249-3252 DT denotes the
T22796 3266-3275 NN denotes transgene
T22797 3253-3256 NN denotes K14
T22798 3257-3265 NN denotes ΔN87βcat
T22799 3256-3257 HYPH denotes -
T22800 3276-3284 VBN denotes compared
T22801 3285-3287 IN denotes to
T22802 3288-3291 DT denotes the
T22803 3302-3310 NN denotes promoter
T22804 3292-3301 JJ denotes intrinsic
T22805 3310-3311 . denotes .
T22806 3311-3567 sentence denotes In contrast, Cre-mediated recombination is seen in E13.5 skin of K14-cre transgenic mice used in this study [16] and K14-cre–mediated truncation of the Apc gene is likely to have occurred by then, in time for the second wave of hair follicle morphgenesis.
T22807 3312-3314 IN denotes In
T22808 3355-3359 VBN denotes seen
T22809 3315-3323 NN denotes contrast
T22810 3323-3325 , denotes ,
T22811 3325-3328 NN denotes Cre
T22812 3329-3337 JJ denotes mediated
T22813 3328-3329 HYPH denotes -
T22814 3338-3351 NN denotes recombination
T22815 3352-3354 VBZ denotes is
T22816 3360-3362 IN denotes in
T22817 3363-3368 NN denotes E13.5
T22818 3369-3373 NN denotes skin
T22819 3374-3376 IN denotes of
T22820 3377-3380 NN denotes K14
T22821 3381-3384 NN denotes cre
T22822 3380-3381 HYPH denotes -
T22823 3396-3400 NNS denotes mice
T22824 3385-3395 JJ denotes transgenic
T22825 3401-3405 VBN denotes used
T22826 3406-3408 IN denotes in
T22827 3409-3413 DT denotes this
T22828 3414-3419 NN denotes study
T22829 3420-3421 -LRB- denotes [
T22830 3421-3423 CD denotes 16
T22831 3423-3424 -RRB- denotes ]
T22832 3425-3428 CC denotes and
T22833 3429-3432 NN denotes K14
T22834 3433-3436 NN denotes cre
T22835 3432-3433 HYPH denotes -
T22836 3437-3445 JJ denotes mediated
T22837 3436-3437 HYPH denotes –
T22838 3446-3456 NN denotes truncation
T22839 3473-3475 VBZ denotes is
T22840 3457-3459 IN denotes of
T22841 3460-3463 DT denotes the
T22842 3468-3472 NN denotes gene
T22843 3464-3467 NN denotes Apc
T22844 3476-3482 JJ denotes likely
T22845 3483-3485 TO denotes to
T22846 3491-3499 VBN denotes occurred
T22847 3486-3490 VB denotes have
T22848 3500-3502 IN denotes by
T22849 3503-3507 RB denotes then
T22850 3507-3509 , denotes ,
T22851 3509-3511 IN denotes in
T22852 3512-3516 NN denotes time
T22853 3517-3520 IN denotes for
T22854 3521-3524 DT denotes the
T22855 3532-3536 NN denotes wave
T22856 3525-3531 JJ denotes second
T22857 3537-3539 IN denotes of
T22858 3540-3544 NN denotes hair
T22859 3545-3553 NN denotes follicle
T22860 3554-3566 NN denotes morphgenesis
T22861 3566-3567 . denotes .
T22862 3567-3786 sentence denotes (2) Another important fact is that in the aforementioned transgenic model the overexpression of transgene is confined to the basal cells of the epidermis and the ORS of hair follicles, where the K14 promoter is active.
T22863 3568-3569 -LRB- denotes (
T22864 3569-3570 LS denotes 2
T22865 3595-3597 VBZ denotes is
T22866 3570-3571 -RRB- denotes )
T22867 3572-3579 DT denotes Another
T22868 3590-3594 NN denotes fact
T22869 3580-3589 JJ denotes important
T22870 3598-3602 IN denotes that
T22871 3677-3685 VBN denotes confined
T22872 3603-3605 IN denotes in
T22873 3606-3609 DT denotes the
T22874 3636-3641 NN denotes model
T22875 3610-3624 JJ denotes aforementioned
T22876 3625-3635 JJ denotes transgenic
T22877 3642-3645 DT denotes the
T22878 3646-3660 NN denotes overexpression
T22879 3661-3663 IN denotes of
T22880 3664-3673 NN denotes transgene
T22881 3674-3676 VBZ denotes is
T22882 3686-3688 IN denotes to
T22883 3689-3692 DT denotes the
T22884 3699-3704 NNS denotes cells
T22885 3693-3698 JJ denotes basal
T22886 3705-3707 IN denotes of
T22887 3708-3711 DT denotes the
T22888 3712-3721 NN denotes epidermis
T22889 3722-3725 CC denotes and
T22890 3726-3729 DT denotes the
T22891 3730-3733 NN denotes ORS
T22892 3734-3736 IN denotes of
T22893 3737-3741 NN denotes hair
T22894 3742-3751 NNS denotes follicles
T22895 3751-3753 , denotes ,
T22896 3753-3758 WRB denotes where
T22897 3776-3778 VBZ denotes is
T22898 3759-3762 DT denotes the
T22899 3767-3775 NN denotes promoter
T22900 3763-3766 NN denotes K14
T22901 3779-3785 JJ denotes active
T22902 3785-3786 . denotes .
T22903 3786-3895 sentence denotes The expression of transgene is hence transient and stops once K14-expressing cells terminally differentiate.
T22904 3787-3790 DT denotes The
T22905 3791-3801 NN denotes expression
T22906 3815-3817 VBZ denotes is
T22907 3802-3804 IN denotes of
T22908 3805-3814 NN denotes transgene
T22909 3818-3823 RB denotes hence
T22910 3824-3833 JJ denotes transient
T22911 3834-3837 CC denotes and
T22912 3838-3843 VBZ denotes stops
T22913 3844-3848 IN denotes once
T22914 3881-3894 VBP denotes differentiate
T22915 3849-3852 NN denotes K14
T22916 3853-3863 VBG denotes expressing
T22917 3852-3853 HYPH denotes -
T22918 3864-3869 NNS denotes cells
T22919 3870-3880 RB denotes terminally
T22920 3894-3895 . denotes .
T22921 3895-4111 sentence denotes In contrast, in our model, K14-cre–mediated deletion of Apc would result in Apc mutation not only in K14 promoter active cells, but remain so in all cell layers that derived from the K14 promoter active progenitors.
T22922 3896-3898 IN denotes In
T22923 3962-3968 VB denotes result
T22924 3899-3907 NN denotes contrast
T22925 3907-3909 , denotes ,
T22926 3909-3911 IN denotes in
T22927 3912-3915 PRP$ denotes our
T22928 3916-3921 NN denotes model
T22929 3921-3923 , denotes ,
T22930 3923-3926 NN denotes K14
T22931 3927-3930 NN denotes cre
T22932 3926-3927 HYPH denotes -
T22933 3931-3939 JJ denotes mediated
T22934 3930-3931 HYPH denotes –
T22935 3940-3948 NN denotes deletion
T22936 3949-3951 IN denotes of
T22937 3952-3955 NN denotes Apc
T22938 3956-3961 MD denotes would
T22939 3969-3971 IN denotes in
T22940 3972-3975 NN denotes Apc
T22941 3976-3984 NN denotes mutation
T22942 3985-3988 RB denotes not
T22943 3994-3996 IN denotes in
T22944 3989-3993 RB denotes only
T22945 3997-4000 NN denotes K14
T22946 4017-4022 NNS denotes cells
T22947 4001-4009 NN denotes promoter
T22948 4010-4016 JJ denotes active
T22949 4022-4024 , denotes ,
T22950 4024-4027 CC denotes but
T22951 4028-4034 VBP denotes remain
T22952 4035-4037 RB denotes so
T22953 4038-4040 IN denotes in
T22954 4041-4044 DT denotes all
T22955 4050-4056 NNS denotes layers
T22956 4045-4049 NN denotes cell
T22957 4057-4061 WDT denotes that
T22958 4062-4069 VBN denotes derived
T22959 4070-4074 IN denotes from
T22960 4075-4078 DT denotes the
T22961 4099-4110 NNS denotes progenitors
T22962 4079-4082 NN denotes K14
T22963 4083-4091 NN denotes promoter
T22964 4092-4098 JJ denotes active
T22965 4110-4111 . denotes .
T22966 4111-4210 sentence denotes These derivatives include the suprabasal epidermis and the entire epithelium of the hair follicle.
T22967 4112-4117 DT denotes These
T22968 4118-4129 NNS denotes derivatives
T22969 4130-4137 VBP denotes include
T22970 4138-4141 DT denotes the
T22971 4153-4162 NN denotes epidermis
T22972 4142-4152 JJ denotes suprabasal
T22973 4163-4166 CC denotes and
T22974 4167-4170 DT denotes the
T22975 4178-4188 NN denotes epithelium
T22976 4171-4177 JJ denotes entire
T22977 4189-4191 IN denotes of
T22978 4192-4195 DT denotes the
T22979 4201-4209 NN denotes follicle
T22980 4196-4200 NN denotes hair
T22981 4209-4210 . denotes .
T22982 4210-4324 sentence denotes Stabilization of β-catenin in a broader population of cells could account for some of the phenotypic differences.
T22983 4211-4224 NN denotes Stabilization
T22984 4277-4284 VB denotes account
T22985 4225-4227 IN denotes of
T22986 4228-4229 NN denotes β
T22987 4230-4237 NN denotes catenin
T22988 4229-4230 HYPH denotes -
T22989 4238-4240 IN denotes in
T22990 4241-4242 DT denotes a
T22991 4251-4261 NN denotes population
T22992 4243-4250 JJR denotes broader
T22993 4262-4264 IN denotes of
T22994 4265-4270 NNS denotes cells
T22995 4271-4276 MD denotes could
T22996 4285-4288 IN denotes for
T22997 4289-4293 DT denotes some
T22998 4294-4296 IN denotes of
T22999 4297-4300 DT denotes the
T23000 4312-4323 NNS denotes differences
T23001 4301-4311 JJ denotes phenotypic
T23002 4323-4324 . denotes .
T23003 4324-4461 sentence denotes However, we did not detect any elevated β-catenin expression in either K1- or K6-positive differentiated cells in postnatal mutant skin.
T23004 4325-4332 RB denotes However
T23005 4345-4351 VB denotes detect
T23006 4332-4334 , denotes ,
T23007 4334-4336 PRP denotes we
T23008 4337-4340 VBD denotes did
T23009 4341-4344 RB denotes not
T23010 4352-4355 DT denotes any
T23011 4375-4385 NN denotes expression
T23012 4356-4364 JJ denotes elevated
T23013 4365-4366 NN denotes β
T23014 4367-4374 NN denotes catenin
T23015 4366-4367 HYPH denotes -
T23016 4386-4388 IN denotes in
T23017 4389-4395 CC denotes either
T23018 4430-4435 NNS denotes cells
T23019 4396-4398 NN denotes K1
T23020 4406-4414 JJ denotes positive
T23021 4398-4399 HYPH denotes -
T23022 4400-4402 CC denotes or
T23023 4403-4405 NN denotes K6
T23024 4405-4406 HYPH denotes -
T23025 4415-4429 VBN denotes differentiated
T23026 4436-4438 IN denotes in
T23027 4439-4448 JJ denotes postnatal
T23028 4456-4460 NN denotes skin
T23029 4449-4455 JJ denotes mutant
T23030 4460-4461 . denotes .
T23031 4461-4701 sentence denotes This indicates that despite the absence of Apc and potential stabilization of β-catenin in derivatives of K14-expressing progenitors, elevated β-catenin expression, and subsequent cell fate determination may only take place in basal cells.
T23032 4462-4466 DT denotes This
T23033 4467-4476 VBZ denotes indicates
T23034 4477-4481 IN denotes that
T23035 4675-4679 VB denotes take
T23036 4482-4489 IN denotes despite
T23037 4490-4493 DT denotes the
T23038 4494-4501 NN denotes absence
T23039 4502-4504 IN denotes of
T23040 4505-4508 NN denotes Apc
T23041 4509-4512 CC denotes and
T23042 4513-4522 JJ denotes potential
T23043 4523-4536 NN denotes stabilization
T23044 4537-4539 IN denotes of
T23045 4540-4541 NN denotes β
T23046 4542-4549 NN denotes catenin
T23047 4541-4542 HYPH denotes -
T23048 4550-4552 IN denotes in
T23049 4553-4564 NNS denotes derivatives
T23050 4565-4567 IN denotes of
T23051 4568-4571 NN denotes K14
T23052 4572-4582 VBG denotes expressing
T23053 4571-4572 HYPH denotes -
T23054 4583-4594 NNS denotes progenitors
T23055 4594-4596 , denotes ,
T23056 4596-4604 JJ denotes elevated
T23057 4615-4625 NN denotes expression
T23058 4605-4606 NN denotes β
T23059 4607-4614 NN denotes catenin
T23060 4606-4607 HYPH denotes -
T23061 4625-4627 , denotes ,
T23062 4627-4630 CC denotes and
T23063 4631-4641 JJ denotes subsequent
T23064 4652-4665 NN denotes determination
T23065 4642-4646 NN denotes cell
T23066 4647-4651 NN denotes fate
T23067 4666-4669 MD denotes may
T23068 4670-4674 RB denotes only
T23069 4680-4685 NN denotes place
T23070 4686-4688 IN denotes in
T23071 4689-4694 JJ denotes basal
T23072 4695-4700 NNS denotes cells
T23073 4700-4701 . denotes .
T23074 4701-4916 sentence denotes (3) We cannot exclude the possibility that given the multifunctional properties of Apc, disruption of its functions other than down-regulation of β-catenin may also have contributed to the observed overt phenotype.
T23075 4702-4703 -LRB- denotes (
T23076 4703-4704 LS denotes 3
T23077 4716-4723 VB denotes exclude
T23078 4704-4705 -RRB- denotes )
T23079 4706-4708 PRP denotes We
T23080 4709-4712 MD denotes can
T23081 4712-4715 RB denotes not
T23082 4724-4727 DT denotes the
T23083 4728-4739 NN denotes possibility
T23084 4740-4744 IN denotes that
T23085 4872-4883 VBN denotes contributed
T23086 4745-4750 VBN denotes given
T23087 4751-4754 DT denotes the
T23088 4771-4781 NNS denotes properties
T23089 4755-4770 JJ denotes multifunctional
T23090 4782-4784 IN denotes of
T23091 4785-4788 NN denotes Apc
T23092 4788-4790 , denotes ,
T23093 4790-4800 NN denotes disruption
T23094 4801-4803 IN denotes of
T23095 4804-4807 PRP$ denotes its
T23096 4808-4817 NNS denotes functions
T23097 4818-4823 JJ denotes other
T23098 4824-4828 IN denotes than
T23099 4829-4833 RB denotes down
T23100 4834-4844 NN denotes regulation
T23101 4833-4834 HYPH denotes -
T23102 4845-4847 IN denotes of
T23103 4848-4849 NN denotes β
T23104 4850-4857 NN denotes catenin
T23105 4849-4850 HYPH denotes -
T23106 4858-4861 MD denotes may
T23107 4862-4866 RB denotes also
T23108 4867-4871 VB denotes have
T23109 4884-4886 IN denotes to
T23110 4887-4890 DT denotes the
T23111 4906-4915 NN denotes phenotype
T23112 4891-4899 VBN denotes observed
T23113 4900-4905 JJ denotes overt
T23114 4915-4916 . denotes .
T23115 4916-5042 sentence denotes While some features of our mutant mice were similar to these transgenic mice, other phenotypic aspects were largely distinct.
T23116 4917-4922 IN denotes While
T23117 4956-4960 VBD denotes were
T23118 4923-4927 DT denotes some
T23119 4928-4936 NNS denotes features
T23120 4937-4939 IN denotes of
T23121 4940-4943 PRP$ denotes our
T23122 4951-4955 NNS denotes mice
T23123 4944-4950 JJ denotes mutant
T23124 5020-5024 VBD denotes were
T23125 4961-4968 JJ denotes similar
T23126 4969-4971 IN denotes to
T23127 4972-4977 DT denotes these
T23128 4989-4993 NNS denotes mice
T23129 4978-4988 JJ denotes transgenic
T23130 4993-4995 , denotes ,
T23131 4995-5000 JJ denotes other
T23132 5012-5019 NNS denotes aspects
T23133 5001-5011 JJ denotes phenotypic
T23134 5025-5032 RB denotes largely
T23135 5033-5041 JJ denotes distinct
T23136 5041-5042 . denotes .
T23137 5042-5277 sentence denotes In addition to aberrant hair follicle morphogenesis, K14-driven loss of Apc caused formation of multiple tooth buds that, like hair follicles, were known to develop through inductive interactions between the epithelium and mesenchyme.
T23138 5043-5045 IN denotes In
T23139 5119-5125 VBD denotes caused
T23140 5046-5054 NN denotes addition
T23141 5055-5057 IN denotes to
T23142 5058-5066 JJ denotes aberrant
T23143 5081-5094 NN denotes morphogenesis
T23144 5067-5071 NN denotes hair
T23145 5072-5080 NN denotes follicle
T23146 5094-5096 , denotes ,
T23147 5096-5099 NN denotes K14
T23148 5100-5106 JJ denotes driven
T23149 5099-5100 HYPH denotes -
T23150 5107-5111 NN denotes loss
T23151 5112-5114 IN denotes of
T23152 5115-5118 NN denotes Apc
T23153 5126-5135 NN denotes formation
T23154 5136-5138 IN denotes of
T23155 5139-5147 JJ denotes multiple
T23156 5154-5158 NNS denotes buds
T23157 5148-5153 NN denotes tooth
T23158 5159-5163 WDT denotes that
T23159 5191-5196 VBN denotes known
T23160 5163-5165 , denotes ,
T23161 5165-5169 IN denotes like
T23162 5170-5174 NN denotes hair
T23163 5175-5184 NNS denotes follicles
T23164 5184-5186 , denotes ,
T23165 5186-5190 VBD denotes were
T23166 5197-5199 TO denotes to
T23167 5200-5207 VB denotes develop
T23168 5208-5215 IN denotes through
T23169 5216-5225 JJ denotes inductive
T23170 5226-5238 NNS denotes interactions
T23171 5239-5246 IN denotes between
T23172 5247-5250 DT denotes the
T23173 5251-5261 NN denotes epithelium
T23174 5262-5265 CC denotes and
T23175 5266-5276 NN denotes mesenchyme
T23176 5276-5277 . denotes .
T23177 5277-5609 sentence denotes This observation was similar to the ectopic tooth buds found in animals misexpressing Lef1 [27], but more severe and was also present at birth, indicating the effect of Apc loss during the initiation of embryonic tooth development, which was evident by aberrant Shh expression in E15.5 embryonic oral epithelium (unpublished data).
T23178 5278-5282 DT denotes This
T23179 5283-5294 NN denotes observation
T23180 5295-5298 VBD denotes was
T23181 5299-5306 JJ denotes similar
T23182 5307-5309 IN denotes to
T23183 5310-5313 DT denotes the
T23184 5328-5332 NNS denotes buds
T23185 5314-5321 JJ denotes ectopic
T23186 5322-5327 NN denotes tooth
T23187 5333-5338 VBN denotes found
T23188 5339-5341 IN denotes in
T23189 5342-5349 NNS denotes animals
T23190 5350-5363 VBG denotes misexpressing
T23191 5364-5368 NN denotes Lef1
T23192 5369-5370 -LRB- denotes [
T23193 5370-5372 CD denotes 27
T23194 5372-5373 -RRB- denotes ]
T23195 5373-5375 , denotes ,
T23196 5375-5378 CC denotes but
T23197 5379-5383 RBR denotes more
T23198 5384-5390 JJ denotes severe
T23199 5391-5394 CC denotes and
T23200 5395-5398 VBD denotes was
T23201 5399-5403 RB denotes also
T23202 5404-5411 JJ denotes present
T23203 5412-5414 IN denotes at
T23204 5415-5420 NN denotes birth
T23205 5420-5422 , denotes ,
T23206 5422-5432 VBG denotes indicating
T23207 5433-5436 DT denotes the
T23208 5437-5443 NN denotes effect
T23209 5444-5446 IN denotes of
T23210 5447-5450 NN denotes Apc
T23211 5451-5455 NN denotes loss
T23212 5456-5462 IN denotes during
T23213 5463-5466 DT denotes the
T23214 5467-5477 NN denotes initiation
T23215 5478-5480 IN denotes of
T23216 5481-5490 JJ denotes embryonic
T23217 5497-5508 NN denotes development
T23218 5491-5496 NN denotes tooth
T23219 5508-5510 , denotes ,
T23220 5510-5515 WDT denotes which
T23221 5516-5519 VBD denotes was
T23222 5520-5527 JJ denotes evident
T23223 5528-5530 IN denotes by
T23224 5531-5539 JJ denotes aberrant
T23225 5544-5554 NN denotes expression
T23226 5540-5543 NN denotes Shh
T23227 5555-5557 IN denotes in
T23228 5558-5563 NN denotes E15.5
T23229 5579-5589 NN denotes epithelium
T23230 5564-5573 JJ denotes embryonic
T23231 5574-5578 JJ denotes oral
T23232 5590-5591 -LRB- denotes (
T23233 5603-5607 NNS denotes data
T23234 5591-5602 JJ denotes unpublished
T23235 5607-5608 -RRB- denotes )
T23236 5608-5609 . denotes .
T23237 5609-5781 sentence denotes It should be noted that although multiple tooth buds were histologically visible (Figure 4O and 4P), these teeth never broke out and the KA mutant mice appeared toothless.
T23238 5610-5612 PRP denotes It
T23239 5623-5628 VBN denotes noted
T23240 5613-5619 MD denotes should
T23241 5620-5622 VB denotes be
T23242 5629-5633 IN denotes that
T23243 5729-5734 VBD denotes broke
T23244 5634-5642 IN denotes although
T23245 5663-5667 VBD denotes were
T23246 5643-5651 JJ denotes multiple
T23247 5658-5662 NNS denotes buds
T23248 5652-5657 NN denotes tooth
T23249 5668-5682 RB denotes histologically
T23250 5683-5690 JJ denotes visible
T23251 5691-5692 -LRB- denotes (
T23252 5699-5701 NN denotes 4O
T23253 5692-5698 NN denotes Figure
T23254 5702-5705 CC denotes and
T23255 5706-5708 NN denotes 4P
T23256 5708-5709 -RRB- denotes )
T23257 5709-5711 , denotes ,
T23258 5711-5716 DT denotes these
T23259 5717-5722 NNS denotes teeth
T23260 5723-5728 RB denotes never
T23261 5735-5738 RP denotes out
T23262 5739-5742 CC denotes and
T23263 5743-5746 DT denotes the
T23264 5757-5761 NNS denotes mice
T23265 5747-5749 NN denotes KA
T23266 5750-5756 JJ denotes mutant
T23267 5762-5770 VBD denotes appeared
T23268 5771-5780 JJ denotes toothless
T23269 5780-5781 . denotes .
T23270 5781-5846 sentence denotes This unusual severe tooth defect is unique to these mutant mice.
T23271 5782-5786 DT denotes This
T23272 5808-5814 NN denotes defect
T23273 5787-5794 JJ denotes unusual
T23274 5795-5801 JJ denotes severe
T23275 5802-5807 NN denotes tooth
T23276 5815-5817 VBZ denotes is
T23277 5818-5824 JJ denotes unique
T23278 5825-5827 IN denotes to
T23279 5828-5833 DT denotes these
T23280 5841-5845 NNS denotes mice
T23281 5834-5840 JJ denotes mutant
T23282 5845-5846 . denotes .
T23283 5846-5943 sentence denotes In addition, neither of the two transgenic mice was postnatally lethal as in the KA mutant mice.
T23284 5847-5849 IN denotes In
T23285 5895-5898 VBD denotes was
T23286 5850-5858 NN denotes addition
T23287 5858-5860 , denotes ,
T23288 5860-5867 DT denotes neither
T23289 5868-5870 IN denotes of
T23290 5871-5874 DT denotes the
T23291 5890-5894 NNS denotes mice
T23292 5875-5878 CD denotes two
T23293 5879-5889 JJ denotes transgenic
T23294 5899-5910 RB denotes postnatally
T23295 5911-5917 JJ denotes lethal
T23296 5918-5920 IN denotes as
T23297 5921-5923 IN denotes in
T23298 5924-5927 DT denotes the
T23299 5938-5942 NNS denotes mice
T23300 5928-5930 NN denotes KA
T23301 5931-5937 JJ denotes mutant
T23302 5942-5943 . denotes .
T23303 5943-6077 sentence denotes We did not find any obvious histopathological abnormalities in the internal organs of KA mice that could contribute to the lethality.
T23304 5944-5946 PRP denotes We
T23305 5955-5959 VB denotes find
T23306 5947-5950 VBD denotes did
T23307 5951-5954 RB denotes not
T23308 5960-5963 DT denotes any
T23309 5990-6003 NNS denotes abnormalities
T23310 5964-5971 JJ denotes obvious
T23311 5972-5989 JJ denotes histopathological
T23312 6004-6006 IN denotes in
T23313 6007-6010 DT denotes the
T23314 6020-6026 NNS denotes organs
T23315 6011-6019 JJ denotes internal
T23316 6027-6029 IN denotes of
T23317 6030-6032 NN denotes KA
T23318 6033-6037 NNS denotes mice
T23319 6038-6042 WDT denotes that
T23320 6049-6059 VB denotes contribute
T23321 6043-6048 MD denotes could
T23322 6060-6062 IN denotes to
T23323 6063-6066 DT denotes the
T23324 6067-6076 NN denotes lethality
T23325 6076-6077 . denotes .
T23326 6077-6259 sentence denotes However, the fact that all the mutants had lower weight (Figure 2F) with hardly any evidence of solid food in their stomach indicates that the mutants might have died of starvation.
T23327 6078-6085 RB denotes However
T23328 6202-6211 VBZ denotes indicates
T23329 6085-6087 , denotes ,
T23330 6087-6090 DT denotes the
T23331 6091-6095 NN denotes fact
T23332 6096-6100 IN denotes that
T23333 6117-6120 VBD denotes had
T23334 6101-6104 PDT denotes all
T23335 6109-6116 NNS denotes mutants
T23336 6105-6108 DT denotes the
T23337 6121-6126 JJR denotes lower
T23338 6127-6133 NN denotes weight
T23339 6134-6135 -LRB- denotes (
T23340 6142-6144 NN denotes 2F
T23341 6135-6141 NN denotes Figure
T23342 6144-6145 -RRB- denotes )
T23343 6146-6150 IN denotes with
T23344 6151-6157 RB denotes hardly
T23345 6162-6170 NN denotes evidence
T23346 6158-6161 DT denotes any
T23347 6171-6173 IN denotes of
T23348 6174-6179 JJ denotes solid
T23349 6180-6184 NN denotes food
T23350 6185-6187 IN denotes in
T23351 6188-6193 PRP$ denotes their
T23352 6194-6201 NN denotes stomach
T23353 6212-6216 IN denotes that
T23354 6240-6244 VBN denotes died
T23355 6217-6220 DT denotes the
T23356 6221-6228 NNS denotes mutants
T23357 6229-6234 MD denotes might
T23358 6235-6239 VB denotes have
T23359 6245-6247 IN denotes of
T23360 6248-6258 NN denotes starvation
T23361 6258-6259 . denotes .
T23362 6259-6378 sentence denotes Dermal fat was reduced in the mutant skin, possibly as a consequence of poor nutrition caused by the absence of teeth.
T23363 6260-6266 JJ denotes Dermal
T23364 6267-6270 NN denotes fat
T23365 6275-6282 VBN denotes reduced
T23366 6271-6274 VBD denotes was
T23367 6283-6285 IN denotes in
T23368 6286-6289 DT denotes the
T23369 6297-6301 NN denotes skin
T23370 6290-6296 JJ denotes mutant
T23371 6301-6303 , denotes ,
T23372 6303-6311 RB denotes possibly
T23373 6312-6314 IN denotes as
T23374 6315-6316 DT denotes a
T23375 6317-6328 NN denotes consequence
T23376 6329-6331 IN denotes of
T23377 6332-6336 JJ denotes poor
T23378 6337-6346 NN denotes nutrition
T23379 6347-6353 VBN denotes caused
T23380 6354-6356 IN denotes by
T23381 6357-6360 DT denotes the
T23382 6361-6368 NN denotes absence
T23383 6369-6371 IN denotes of
T23384 6372-6377 NNS denotes teeth
T23385 6377-6378 . denotes .
T23386 6378-6591 sentence denotes Since the weight loss in KA mutants started from P8–P10 while pups were still nursed by their mothers, starvation due to lack of teeth cannot be the sole cause of death, but is likely to be a contributing factor.
T23387 6379-6384 IN denotes Since
T23388 6415-6422 VBN denotes started
T23389 6385-6388 DT denotes the
T23390 6396-6400 NN denotes loss
T23391 6389-6395 NN denotes weight
T23392 6401-6403 IN denotes in
T23393 6404-6406 NN denotes KA
T23394 6407-6414 NNS denotes mutants
T23395 6521-6523 VB denotes be
T23396 6423-6427 IN denotes from
T23397 6428-6430 NN denotes P8
T23398 6430-6431 SYM denotes –
T23399 6431-6434 NN denotes P10
T23400 6435-6440 IN denotes while
T23401 6457-6463 VBN denotes nursed
T23402 6441-6445 NNS denotes pups
T23403 6446-6450 VBD denotes were
T23404 6451-6456 RB denotes still
T23405 6464-6466 IN denotes by
T23406 6467-6472 PRP$ denotes their
T23407 6473-6480 NNS denotes mothers
T23408 6480-6482 , denotes ,
T23409 6482-6492 NN denotes starvation
T23410 6493-6496 IN denotes due
T23411 6497-6499 IN denotes to
T23412 6500-6504 NN denotes lack
T23413 6505-6507 IN denotes of
T23414 6508-6513 NNS denotes teeth
T23415 6514-6517 MD denotes can
T23416 6517-6520 RB denotes not
T23417 6524-6527 DT denotes the
T23418 6533-6538 NN denotes cause
T23419 6528-6532 JJ denotes sole
T23420 6539-6541 IN denotes of
T23421 6542-6547 NN denotes death
T23422 6547-6549 , denotes ,
T23423 6549-6552 CC denotes but
T23424 6553-6555 VBZ denotes is
T23425 6556-6562 JJ denotes likely
T23426 6563-6565 TO denotes to
T23427 6566-6568 VB denotes be
T23428 6569-6570 DT denotes a
T23429 6584-6590 NN denotes factor
T23430 6571-6583 VBG denotes contributing
T23431 6590-6591 . denotes .
T23432 6591-6788 sentence denotes Absence of teeth and mammary glands have been observed in mice deficient in Lef1 and ectopically expressing Dkk1 [29,30] but their absence was due to the block in development before the bud stage.
T23433 6592-6599 NN denotes Absence
T23434 6638-6646 VBN denotes observed
T23435 6600-6602 IN denotes of
T23436 6603-6608 NNS denotes teeth
T23437 6609-6612 CC denotes and
T23438 6613-6620 JJ denotes mammary
T23439 6621-6627 NNS denotes glands
T23440 6628-6632 VBP denotes have
T23441 6633-6637 VBN denotes been
T23442 6647-6649 IN denotes in
T23443 6650-6654 NNS denotes mice
T23444 6655-6664 JJ denotes deficient
T23445 6665-6667 IN denotes in
T23446 6668-6672 NN denotes Lef1
T23447 6673-6676 CC denotes and
T23448 6677-6688 RB denotes ectopically
T23449 6689-6699 VBG denotes expressing
T23450 6700-6704 NN denotes Dkk1
T23451 6705-6706 -LRB- denotes [
T23452 6709-6711 CD denotes 30
T23453 6706-6708 CD denotes 29
T23454 6708-6709 , denotes ,
T23455 6711-6712 -RRB- denotes ]
T23456 6713-6716 CC denotes but
T23457 6717-6722 PRP$ denotes their
T23458 6723-6730 NN denotes absence
T23459 6731-6734 VBD denotes was
T23460 6735-6738 IN denotes due
T23461 6739-6741 IN denotes to
T23462 6742-6745 DT denotes the
T23463 6746-6751 NN denotes block
T23464 6752-6754 IN denotes in
T23465 6755-6766 NN denotes development
T23466 6767-6773 IN denotes before
T23467 6774-6777 DT denotes the
T23468 6782-6787 NN denotes stage
T23469 6778-6781 NN denotes bud
T23470 6787-6788 . denotes .
T23471 6788-6926 sentence denotes Hence, neither loss nor excess of tooth bud formation allows proper development of teeth for mice to have a healthy diet and normal life.
T23472 6789-6794 RB denotes Hence
T23473 6843-6849 VBZ denotes allows
T23474 6794-6796 , denotes ,
T23475 6796-6803 CC denotes neither
T23476 6804-6808 NN denotes loss
T23477 6809-6812 CC denotes nor
T23478 6813-6819 NN denotes excess
T23479 6820-6822 IN denotes of
T23480 6823-6828 JJ denotes tooth
T23481 6829-6832 NN denotes bud
T23482 6833-6842 NN denotes formation
T23483 6850-6856 JJ denotes proper
T23484 6857-6868 NN denotes development
T23485 6869-6871 IN denotes of
T23486 6872-6877 NNS denotes teeth
T23487 6878-6881 IN denotes for
T23488 6890-6894 VB denotes have
T23489 6882-6886 NNS denotes mice
T23490 6887-6889 TO denotes to
T23491 6895-6896 DT denotes a
T23492 6905-6909 NN denotes diet
T23493 6897-6904 JJ denotes healthy
T23494 6910-6913 CC denotes and
T23495 6914-6920 JJ denotes normal
T23496 6921-6925 NN denotes life
T23497 6925-6926 . denotes .
T23498 6926-7052 sentence denotes Mechanistic studies to understand how increased levels of β-catenin leads to altered skin and tooth phenotypes are under way.
T23499 6927-6938 JJ denotes Mechanistic
T23500 6939-6946 NNS denotes studies
T23501 7038-7041 VBP denotes are
T23502 6947-6949 TO denotes to
T23503 6950-6960 VB denotes understand
T23504 6961-6964 WRB denotes how
T23505 6995-7000 VBZ denotes leads
T23506 6965-6974 VBN denotes increased
T23507 6975-6981 NNS denotes levels
T23508 6982-6984 IN denotes of
T23509 6985-6986 NN denotes β
T23510 6987-6994 NN denotes catenin
T23511 6986-6987 HYPH denotes -
T23512 7001-7003 IN denotes to
T23513 7004-7011 JJ denotes altered
T23514 7027-7037 NNS denotes phenotypes
T23515 7012-7016 NN denotes skin
T23516 7017-7020 CC denotes and
T23517 7021-7026 NN denotes tooth
T23518 7042-7047 IN denotes under
T23519 7048-7051 NN denotes way
T23520 7051-7052 . denotes .
R5954 T22183 T22184 nmod Apc,Morphogenesis
R5955 T22185 T22183 cc and,Apc
R5956 T22186 T22187 compound Hair,Follicle
R5957 T22187 T22183 conj Follicle,Apc
R5958 T22189 T22190 amod Current,models
R5959 T22190 T22191 nsubj models,suggest
R5960 T22192 T22190 prep of,models
R5961 T22193 T22194 compound hair,follicle
R5962 T22194 T22195 compound follicle,development
R5963 T22195 T22192 pobj development,of
R5964 T22196 T22197 mark that,achieved
R5965 T22197 T22191 ccomp achieved,suggest
R5966 T22198 T22199 det the,establishment
R5967 T22199 T22197 nsubjpass establishment,achieved
R5968 T22200 T22199 prep of,establishment
R5969 T22201 T22202 det a,array
R5970 T22202 T22200 pobj array,of
R5971 T22203 T22202 amod regular,array
R5972 T22204 T22202 prep of,array
R5973 T22205 T22204 pobj placodes,of
R5974 T22206 T22202 prep in,array
R5975 T22207 T22208 det the,epithelium
R5976 T22208 T22206 pobj epithelium,in
R5977 T22209 T22208 compound surface,epithelium
R5978 T22210 T22199 prep in,establishment
R5979 T22211 T22210 pobj response,in
R5980 T22212 T22211 prep to,response
R5981 T22213 T22214 det the,message
R5982 T22214 T22212 pobj message,to
R5983 T22215 T22214 amod first,message
R5984 T22216 T22214 amod dermal,message
R5985 T22217 T22197 auxpass is,achieved
R5986 T22218 T22197 prep through,achieved
R5987 T22219 T22220 det the,activities
R5988 T22220 T22218 pobj activities,through
R5989 T22221 T22220 amod competing,activities
R5990 T22222 T22220 prep of,activities
R5991 T22223 T22222 pobj molecules,of
R5992 T22224 T22225 dep that,promote
R5993 T22225 T22223 relcl promote,molecules
R5994 T22226 T22225 cc or,promote
R5995 T22227 T22225 conj repress,promote
R5996 T22228 T22229 compound placode,fate
R5997 T22229 T22227 dobj fate,repress
R5998 T22230 T22231 punct [,24
R5999 T22231 T22191 parataxis 24,suggest
R6000 T22232 T22231 punct ],24
R6001 T22233 T22191 punct .,suggest
R6002 T22235 T22236 expl There,is
R6003 T22237 T22238 amod accumulating,evidence
R6004 T22238 T22236 attr evidence,is
R6005 T22239 T22240 mark that,involved
R6006 T22240 T22238 acl involved,evidence
R6007 T22241 T22240 nsubjpass activation,involved
R6008 T22242 T22241 prep of,activation
R6009 T22243 T22244 det the,pathway
R6010 T22244 T22242 pobj pathway,of
R6011 T22245 T22244 compound Wnt,pathway
R6012 T22246 T22244 compound signaling,pathway
R6013 T22247 T22241 prep in,activation
R6014 T22248 T22249 det the,dermis
R6015 T22249 T22247 pobj dermis,in
R6016 T22250 T22240 aux may,involved
R6017 T22251 T22240 auxpass be,involved
R6018 T22252 T22240 prep in,involved
R6019 T22253 T22252 pcomp establishing,in
R6020 T22254 T22255 det the,signal
R6021 T22255 T22253 dobj signal,establishing
R6022 T22256 T22255 amod first,signal
R6023 T22257 T22255 amod dermal,signal
R6024 T22258 T22236 punct .,is
R6025 T22260 T22261 amod Experimental,activation
R6026 T22261 T22262 nsubj activation,induces
R6027 T22263 T22261 prep of,activation
R6028 T22264 T22265 amod epithelial,signaling
R6029 T22265 T22263 pobj signaling,of
R6030 T22266 T22267 compound β,catenin
R6031 T22267 T22265 compound catenin,signaling
R6032 T22268 T22267 punct -,catenin
R6033 T22269 T22261 punct (,activation
R6034 T22270 T22261 prep by,activation
R6035 T22271 T22270 pobj expression,by
R6036 T22272 T22271 prep of,expression
R6037 T22273 T22274 compound N,terminal
R6038 T22274 T22276 npadvmod terminal,truncated
R6039 T22275 T22274 punct -,terminal
R6040 T22276 T22278 amod truncated,forms
R6041 T22277 T22276 punct –,truncated
R6042 T22278 T22272 pobj forms,of
R6043 T22279 T22278 punct ", ",forms
R6044 T22280 T22281 advmod constitutively,stabilized
R6045 T22281 T22278 amod stabilized,forms
R6046 T22282 T22278 prep of,forms
R6047 T22283 T22284 compound β,catenin
R6048 T22284 T22282 pobj catenin,of
R6049 T22285 T22284 punct -,catenin
R6050 T22286 T22271 cc or,expression
R6051 T22287 T22288 amod ectopic,expression
R6052 T22288 T22271 conj expression,expression
R6053 T22289 T22288 prep of,expression
R6054 T22290 T22289 pobj Lef1,of
R6055 T22291 T22262 punct ),induces
R6056 T22292 T22293 amod ectopic,follicles
R6057 T22293 T22262 dobj follicles,induces
R6058 T22294 T22262 prep in,induces
R6059 T22295 T22296 preconj both,mouse
R6060 T22296 T22297 nmod mouse,skin
R6061 T22297 T22294 pobj skin,in
R6062 T22298 T22296 cc and,mouse
R6063 T22299 T22296 conj chick,mouse
R6064 T22300 T22301 punct [,25
R6065 T22301 T22262 parataxis 25,induces
R6066 T22302 T22303 punct –,27
R6067 T22303 T22301 prep 27,25
R6068 T22304 T22301 punct ],25
R6069 T22305 T22262 punct .,induces
R6070 T22307 T22308 advmod Conversely,results
R6071 T22309 T22308 punct ", ",results
R6072 T22310 T22311 amod down,regulation
R6073 T22311 T22308 nsubj regulation,results
R6074 T22312 T22311 punct -,regulation
R6075 T22313 T22311 prep of,regulation
R6076 T22314 T22315 compound β,catenin
R6077 T22315 T22317 compound catenin,signaling
R6078 T22316 T22315 punct -,catenin
R6079 T22317 T22313 pobj signaling,of
R6080 T22318 T22311 punct (,regulation
R6081 T22319 T22311 prep through,regulation
R6082 T22320 T22321 npadvmod Lef1,knock
R6083 T22321 T22322 amod knock,expression
R6084 T22322 T22319 pobj expression,through
R6085 T22323 T22321 punct -,knock
R6086 T22324 T22321 prt out,knock
R6087 T22325 T22322 punct ", ",expression
R6088 T22326 T22322 amod ectopic,expression
R6089 T22327 T22322 prep of,expression
R6090 T22328 T22329 compound Wnt,inhibitor
R6091 T22329 T22327 pobj inhibitor,of
R6092 T22330 T22329 appos Dkk1,inhibitor
R6093 T22331 T22322 cc or,expression
R6094 T22332 T22333 amod conditional,deletion
R6095 T22333 T22322 conj deletion,expression
R6096 T22334 T22333 prep of,deletion
R6097 T22335 T22336 compound β,catenin
R6098 T22336 T22334 pobj catenin,of
R6099 T22337 T22336 punct -,catenin
R6100 T22338 T22333 prep in,deletion
R6101 T22339 T22338 pobj epidermis,in
R6102 T22340 T22308 punct ),results
R6103 T22341 T22308 prep in,results
R6104 T22342 T22341 pobj loss,in
R6105 T22343 T22342 prep of,loss
R6106 T22344 T22343 pobj vibrissae,of
R6107 T22345 T22344 cc and,vibrissae
R6108 T22346 T22347 det some,follicles
R6109 T22347 T22344 conj follicles,vibrissae
R6110 T22348 T22347 compound pelage,follicles
R6111 T22349 T22308 prep in,results
R6112 T22350 T22349 pobj mice,in
R6113 T22351 T22352 punct [,28
R6114 T22352 T22308 parataxis 28,results
R6115 T22353 T22354 punct –,30
R6116 T22354 T22352 prep 30,28
R6117 T22355 T22352 punct ],28
R6118 T22356 T22308 punct .,results
R6119 T22358 T22359 poss Our,finding
R6120 T22359 T22360 nsubj finding,is
R6121 T22361 T22362 mark that,resulted
R6122 T22362 T22359 acl resulted,finding
R6123 T22363 T22364 npadvmod K14,driven
R6124 T22364 T22366 amod driven,loss
R6125 T22365 T22364 punct -,driven
R6126 T22366 T22362 nsubj loss,resulted
R6127 T22367 T22366 compound Apc,loss
R6128 T22368 T22366 prep in,loss
R6129 T22369 T22370 amod embryonic,ectoderm
R6130 T22370 T22368 pobj ectoderm,in
R6131 T22371 T22362 prep in,resulted
R6132 T22372 T22373 advmod irregularly,spaced
R6133 T22373 T22374 amod spaced,initiation
R6134 T22374 T22371 pobj initiation,in
R6135 T22375 T22373 cc and,spaced
R6136 T22376 T22377 advmod often,clustered
R6137 T22377 T22373 conj clustered,spaced
R6138 T22378 T22377 advmod tightly,clustered
R6139 T22379 T22374 amod abnormal,initiation
R6140 T22380 T22374 compound hair,initiation
R6141 T22381 T22374 compound placode,initiation
R6142 T22382 T22374 cc and,initiation
R6143 T22383 T22384 compound follicle,morphogenesis
R6144 T22384 T22374 conj morphogenesis,initiation
R6145 T22385 T22386 punct (,4F
R6146 T22386 T22374 parataxis 4F,initiation
R6147 T22387 T22386 compound Figures,4F
R6148 T22388 T22386 punct ", ",4F
R6149 T22389 T22386 conj 5B,4F
R6150 T22390 T22389 punct ", ",5B
R6151 T22391 T22389 conj 5D,5B
R6152 T22392 T22391 punct ", ",5D
R6153 T22393 T22391 cc and,5D
R6154 T22394 T22391 conj 5F,5D
R6155 T22395 T22386 punct ),4F
R6156 T22396 T22397 advmod as,as
R6157 T22397 T22371 cc as,in
R6158 T22398 T22397 advmod well,as
R6159 T22399 T22371 conj in,in
R6160 T22400 T22401 det the,development
R6161 T22401 T22399 pobj development,in
R6162 T22402 T22401 prep of,development
R6163 T22403 T22404 amod multiple,buds
R6164 T22404 T22402 pobj buds,of
R6165 T22405 T22404 compound tooth,buds
R6166 T22406 T22407 punct (,4O
R6167 T22407 T22404 parataxis 4O,buds
R6168 T22408 T22407 compound Figure,4O
R6169 T22409 T22407 cc and,4O
R6170 T22410 T22407 conj 4P,4O
R6171 T22411 T22407 punct ),4O
R6172 T22412 T22360 punct ", ",is
R6173 T22413 T22360 prep in,is
R6174 T22414 T22413 pobj line,in
R6175 T22415 T22414 prep with,line
R6176 T22416 T22417 det the,effects
R6177 T22417 T22415 pobj effects,with
R6178 T22418 T22417 acl seen,effects
R6179 T22419 T22418 prep in,seen
R6180 T22420 T22419 pobj activation,in
R6181 T22421 T22420 prep of,activation
R6182 T22422 T22423 amod epithelial,signaling
R6183 T22423 T22421 pobj signaling,of
R6184 T22424 T22425 compound β,catenin
R6185 T22425 T22423 compound catenin,signaling
R6186 T22426 T22425 punct -,catenin
R6187 T22427 T22420 prep during,activation
R6188 T22428 T22429 compound placode,formation
R6189 T22429 T22427 pobj formation,during
R6190 T22430 T22360 punct ", ",is
R6191 T22431 T22360 advcl indicating,is
R6192 T22432 T22433 det the,role
R6193 T22433 T22431 dobj role,indicating
R6194 T22434 T22433 prep of,role
R6195 T22435 T22434 pobj Apc,of
R6196 T22436 T22433 prep in,role
R6197 T22437 T22436 pobj specification,in
R6198 T22438 T22437 prep of,specification
R6199 T22439 T22440 amod embryonic,cells
R6200 T22440 T22438 pobj cells,of
R6201 T22441 T22440 amod ectodermal,cells
R6202 T22442 T22440 compound stem,cells
R6203 T22443 T22444 aux to,produce
R6204 T22444 T22437 acl produce,specification
R6205 T22445 T22446 det a,follicle
R6206 T22446 T22444 dobj follicle,produce
R6207 T22447 T22446 compound hair,follicle
R6208 T22448 T22360 punct .,is
R6209 T22450 T22451 prep Given,lead
R6210 T22452 T22453 det the,role
R6211 T22453 T22450 pobj role,Given
R6212 T22454 T22453 prep of,role
R6213 T22455 T22454 pobj Apc,of
R6214 T22456 T22453 prep in,role
R6215 T22457 T22458 advmod down,regulation
R6216 T22458 T22456 pobj regulation,in
R6217 T22459 T22458 punct -,regulation
R6218 T22460 T22458 prep of,regulation
R6219 T22461 T22462 compound β,catenin
R6220 T22462 T22460 pobj catenin,of
R6221 T22463 T22462 punct -,catenin
R6222 T22464 T22451 punct ", ",lead
R6223 T22465 T22451 nsubj loss,lead
R6224 T22466 T22465 prep of,loss
R6225 T22467 T22466 pobj Apc,of
R6226 T22468 T22451 aux would,lead
R6227 T22469 T22451 advmod inevitably,lead
R6228 T22470 T22451 prep to,lead
R6229 T22471 T22472 amod altered,expression
R6230 T22472 T22470 pobj expression,to
R6231 T22473 T22472 prep of,expression
R6232 T22474 T22475 compound β,catenin
R6233 T22475 T22473 pobj catenin,of
R6234 T22476 T22475 punct -,catenin
R6235 T22477 T22451 prep in,lead
R6236 T22478 T22479 amod ectodermal,cells
R6237 T22479 T22477 pobj cells,in
R6238 T22480 T22451 prep during,lead
R6239 T22481 T22482 det the,formation
R6240 T22482 T22480 pobj formation,during
R6241 T22483 T22484 compound hair,placode
R6242 T22484 T22482 compound placode,formation
R6243 T22485 T22451 punct ", ",lead
R6244 T22486 T22451 advcl giving,lead
R6245 T22487 T22486 dobj rise,giving
R6246 T22488 T22486 prep to,giving
R6247 T22489 T22490 amod aberrant,growth
R6248 T22490 T22488 pobj growth,to
R6249 T22491 T22490 amod follicular,growth
R6250 T22492 T22486 prep throughout,giving
R6251 T22493 T22494 det the,epidermis
R6252 T22494 T22492 pobj epidermis,throughout
R6253 T22495 T22494 amod embryonic,epidermis
R6254 T22496 T22494 punct ", ",epidermis
R6255 T22497 T22494 prep including,epidermis
R6256 T22498 T22499 det the,footpads
R6257 T22499 T22497 pobj footpads,including
R6258 T22500 T22499 punct ", ",footpads
R6259 T22501 T22502 advmod where,hairless
R6260 T22502 T22499 relcl hairless,footpads
R6261 T22503 T22502 advmod normally,hairless
R6262 T22504 T22505 punct (,5B
R6263 T22505 T22451 parataxis 5B,lead
R6264 T22506 T22505 compound Figure,5B
R6265 T22507 T22505 punct ", ",5B
R6266 T22508 T22505 conj 5D,5B
R6267 T22509 T22508 punct ", ",5D
R6268 T22510 T22508 conj 5F,5D
R6269 T22511 T22510 punct ", ",5F
R6270 T22512 T22510 cc and,5F
R6271 T22513 T22510 conj 5H,5F
R6272 T22514 T22505 punct ),5B
R6273 T22515 T22451 punct .,lead
R6274 T22517 T22518 prep Of,are
R6275 T22519 T22517 pobj interest,Of
R6276 T22520 T22521 det the,similarities
R6277 T22521 T22518 nsubj similarities,are
R6278 T22522 T22521 amod phenotypic,similarities
R6279 T22523 T22521 cc and,similarities
R6280 T22524 T22521 conj differences,similarities
R6281 T22525 T22521 prep between,similarities
R6282 T22526 T22527 poss our,mice
R6283 T22527 T22525 pobj mice,between
R6284 T22528 T22527 nmod KA,mice
R6285 T22529 T22527 amod mutant,mice
R6286 T22530 T22527 cc and,mice
R6287 T22531 T22532 det the,mice
R6288 T22532 T22527 conj mice,mice
R6289 T22533 T22534 advmod previously,described
R6290 T22534 T22532 amod described,mice
R6291 T22535 T22536 nmod K14,ΔN87βcat
R6292 T22536 T22532 nmod ΔN87βcat,mice
R6293 T22537 T22536 punct -,ΔN87βcat
R6294 T22538 T22532 amod transgenic,mice
R6295 T22539 T22532 acl expressing,mice
R6296 T22540 T22541 amod stable,catenin
R6297 T22541 T22539 dobj catenin,expressing
R6298 T22542 T22541 compound β,catenin
R6299 T22543 T22541 punct -,catenin
R6300 T22544 T22539 prep under,expressing
R6301 T22545 T22546 det the,control
R6302 T22546 T22544 pobj control,under
R6303 T22547 T22546 prep of,control
R6304 T22548 T22549 compound K14,promoter
R6305 T22549 T22547 pobj promoter,of
R6306 T22550 T22551 punct [,25
R6307 T22551 T22549 parataxis 25,promoter
R6308 T22552 T22551 punct ],25
R6309 T22553 T22549 cc and,promoter
R6310 T22554 T22555 nmod K14,Lef1
R6311 T22555 T22557 nmod Lef1,mice
R6312 T22556 T22555 punct -,Lef1
R6313 T22557 T22549 conj mice,promoter
R6314 T22558 T22555 amod transgenic,Lef1
R6315 T22559 T22560 punct [,27
R6316 T22560 T22557 parataxis 27,mice
R6317 T22561 T22560 punct ],27
R6318 T22562 T22518 punct .,are
R6319 T22564 T22565 advmod Surprisingly,shared
R6320 T22566 T22565 punct ", ",shared
R6321 T22567 T22568 poss our,mice
R6322 T22568 T22565 nsubj mice,shared
R6323 T22569 T22568 amod mutant,mice
R6324 T22570 T22571 amod more,similarities
R6325 T22571 T22565 dobj similarities,shared
R6326 T22572 T22565 prep with,shared
R6327 T22573 T22574 det the,mice
R6328 T22574 T22572 pobj mice,with
R6329 T22575 T22576 compound K14,Lef1
R6330 T22576 T22574 compound Lef1,mice
R6331 T22577 T22576 punct -,Lef1
R6332 T22578 T22565 prep than,shared
R6333 T22579 T22580 det the,mice
R6334 T22580 T22578 pobj mice,than
R6335 T22581 T22582 nmod K14,ΔN87βcat
R6336 T22582 T22580 nmod ΔN87βcat,mice
R6337 T22583 T22582 punct -,ΔN87βcat
R6338 T22584 T22580 amod transgenic,mice
R6339 T22585 T22565 punct .,shared
R6340 T22587 T22588 prep For,displayed
R6341 T22589 T22587 pobj example,For
R6342 T22590 T22588 punct ", ",displayed
R6343 T22591 T22592 det the,mice
R6344 T22592 T22588 nsubj mice,displayed
R6345 T22593 T22592 nmod KA,mice
R6346 T22594 T22592 amod mutant,mice
R6347 T22595 T22596 det the,whiskers
R6348 T22596 T22588 dobj whiskers,displayed
R6349 T22597 T22596 amod disoriented,whiskers
R6350 T22598 T22597 cc and,disoriented
R6351 T22599 T22597 conj short,disoriented
R6352 T22600 T22596 punct ", ",whiskers
R6353 T22601 T22596 amod curly,whiskers
R6354 T22602 T22596 acl seen,whiskers
R6355 T22603 T22602 prep in,seen
R6356 T22604 T22605 compound K14,Lef1but
R6357 T22605 T22603 pobj Lef1but,in
R6358 T22606 T22605 punct -,Lef1but
R6359 T22607 T22603 neg not,in
R6360 T22608 T22603 prep in,in
R6361 T22609 T22610 nmod K14,ΔN87βcat
R6362 T22610 T22612 nmod ΔN87βcat,mice
R6363 T22611 T22610 punct -,ΔN87βcat
R6364 T22612 T22608 pobj mice,in
R6365 T22613 T22612 amod transgenic,mice
R6366 T22614 T22588 punct .,displayed
R6367 T22616 T22617 prep In,displayed
R6368 T22618 T22616 pobj addition,In
R6369 T22619 T22617 punct ", ",displayed
R6370 T22620 T22621 nmod KA,mice
R6371 T22621 T22617 nsubj mice,displayed
R6372 T22622 T22621 amod mutant,mice
R6373 T22623 T22624 det a,coat
R6374 T22624 T22617 dobj coat,displayed
R6375 T22625 T22624 amod disorganized,coat
R6376 T22626 T22624 compound hair,coat
R6377 T22627 T22624 acl beginning,coat
R6378 T22628 T22627 prep with,beginning
R6379 T22629 T22630 det the,emergence
R6380 T22630 T22628 pobj emergence,with
R6381 T22631 T22630 prep of,emergence
R6382 T22632 T22633 amod neonatal,hairs
R6383 T22633 T22631 pobj hairs,of
R6384 T22634 T22633 punct ", ",hairs
R6385 T22635 T22633 amod similar,hairs
R6386 T22636 T22635 prep to,similar
R6387 T22637 T22636 pobj that,to
R6388 T22638 T22637 acl observed,that
R6389 T22639 T22638 prep in,observed
R6390 T22640 T22641 compound K14,Lef1
R6391 T22641 T22643 compound Lef1,mice
R6392 T22642 T22641 punct -,Lef1
R6393 T22643 T22639 pobj mice,in
R6394 T22644 T22617 punct ", ",displayed
R6395 T22645 T22646 mark whereas,was
R6396 T22646 T22617 advcl was,displayed
R6397 T22647 T22646 prep in,was
R6398 T22648 T22649 compound K14,ΔN87βcat
R6399 T22649 T22651 compound ΔN87βcat,mice
R6400 T22650 T22649 punct -,ΔN87βcat
R6401 T22651 T22647 pobj mice,in
R6402 T22652 T22646 punct ", ",was
R6403 T22653 T22654 amod embryonic,morphogenesis
R6404 T22654 T22646 nsubj morphogenesis,was
R6405 T22655 T22656 compound hair,follicle
R6406 T22656 T22654 compound follicle,morphogenesis
R6407 T22657 T22646 acomp unaffected,was
R6408 T22658 T22646 cc and,was
R6409 T22659 T22660 amod other,changes
R6410 T22660 T22662 nsubj changes,emerged
R6411 T22661 T22660 compound skin,changes
R6412 T22662 T22646 conj emerged,was
R6413 T22663 T22662 advmod only,emerged
R6414 T22664 T22662 advmod postnatally,emerged
R6415 T22665 T22617 punct .,displayed
R6416 T22667 T22668 det The,reason
R6417 T22668 T22669 nsubjpass reason,attributed
R6418 T22670 T22668 prep for,reason
R6419 T22671 T22672 det this,difference
R6420 T22672 T22670 pobj difference,for
R6421 T22673 T22669 aux could,attributed
R6422 T22674 T22669 auxpass be,attributed
R6423 T22675 T22669 prep to,attributed
R6424 T22676 T22675 pobj one,to
R6425 T22677 T22676 cc or,one
R6426 T22678 T22676 conj all,one
R6427 T22679 T22676 prep of,one
R6428 T22680 T22681 nummod three,factors
R6429 T22681 T22679 pobj factors,of
R6430 T22682 T22681 amod possible,factors
R6431 T22683 T22681 amod contributing,factors
R6432 T22684 T22669 punct .,attributed
R6433 T22686 T22687 punct (,1
R6434 T22687 T22688 meta 1,influence
R6435 T22689 T22687 punct ),1
R6436 T22690 T22691 mark Although,known
R6437 T22691 T22688 advcl known,influence
R6438 T22692 T22693 det the,promoter
R6439 T22693 T22691 nsubjpass promoter,known
R6440 T22694 T22693 compound K14,promoter
R6441 T22695 T22693 appos itself,promoter
R6442 T22696 T22691 auxpass is,known
R6443 T22697 T22698 aux to,initiate
R6444 T22698 T22691 xcomp initiate,known
R6445 T22699 T22700 det the,expression
R6446 T22700 T22698 dobj expression,initiate
R6447 T22701 T22698 prep at,initiate
R6448 T22702 T22701 pobj E9.5,at
R6449 T22703 T22691 cc and,known
R6450 T22704 T22691 conj elevated,known
R6451 T22705 T22704 advmod dramatically,elevated
R6452 T22706 T22704 prep by,elevated
R6453 T22707 T22706 pobj E13.5,by
R6454 T22708 T22709 punct –,E14.5
R6455 T22709 T22707 prep E14.5,E13.5
R6456 T22710 T22711 punct [,31
R6457 T22711 T22704 parataxis 31,elevated
R6458 T22712 T22711 nummod 19,31
R6459 T22713 T22711 punct ",",31
R6460 T22714 T22711 punct ],31
R6461 T22715 T22688 punct ", ",influence
R6462 T22716 T22717 amod many,factors
R6463 T22717 T22688 nsubj factors,influence
R6464 T22718 T22688 aux could,influence
R6465 T22719 T22720 det the,expression
R6466 T22720 T22688 dobj expression,influence
R6467 T22721 T22720 prep of,expression
R6468 T22722 T22723 compound promoter,transgene
R6469 T22723 T22725 compound transgene,construct
R6470 T22724 T22723 punct /,transgene
R6471 T22725 T22721 pobj construct,of
R6472 T22726 T22688 prep in,influence
R6473 T22727 T22728 amod transgenic,mice
R6474 T22728 T22726 pobj mice,in
R6475 T22729 T22688 punct .,influence
R6476 T22731 T22732 nsubj One,has
R6477 T22733 T22731 prep of,One
R6478 T22734 T22735 det the,considerations
R6479 T22735 T22733 pobj considerations,of
R6480 T22736 T22737 advmod most,important
R6481 T22737 T22735 amod important,considerations
R6482 T22738 T22739 aux to,do
R6483 T22739 T22732 xcomp do,has
R6484 T22740 T22739 prep with,do
R6485 T22741 T22742 det the,site
R6486 T22742 T22740 pobj site,with
R6487 T22743 T22742 compound integration,site
R6488 T22744 T22742 prep of,site
R6489 T22745 T22746 det the,transgene
R6490 T22746 T22744 pobj transgene,of
R6491 T22747 T22739 prep in,do
R6492 T22748 T22749 det the,genome
R6493 T22749 T22747 pobj genome,in
R6494 T22750 T22749 compound mouse,genome
R6495 T22751 T22732 punct .,has
R6496 T22753 T22754 prep Depending,vary
R6497 T22755 T22753 prep on,Depending
R6498 T22756 T22757 det the,location
R6499 T22757 T22755 pobj location,on
R6500 T22758 T22757 prep of,location
R6501 T22759 T22758 pobj integration,of
R6502 T22760 T22754 punct ", ",vary
R6503 T22761 T22762 det the,activity
R6504 T22762 T22754 nsubj activity,vary
R6505 T22763 T22762 amod transcriptional,activity
R6506 T22764 T22762 prep of,activity
R6507 T22765 T22766 advmod even,transgene
R6508 T22766 T22764 pobj transgene,of
R6509 T22767 T22766 det the,transgene
R6510 T22768 T22766 amod same,transgene
R6511 T22769 T22754 aux could,vary
R6512 T22770 T22754 advmod considerably,vary
R6513 T22771 T22754 punct .,vary
R6514 T22773 T22774 nsubj It,is
R6515 T22775 T22774 acomp possible,is
R6516 T22776 T22777 mark that,be
R6517 T22777 T22774 ccomp be,is
R6518 T22778 T22779 det the,lack
R6519 T22779 T22777 nsubj lack,be
R6520 T22780 T22779 amod apparent,lack
R6521 T22781 T22779 prep of,lack
R6522 T22782 T22783 compound ΔN87βcat,function
R6523 T22783 T22781 pobj function,of
R6524 T22784 T22779 prep in,lack
R6525 T22785 T22784 pobj embryogenesis,in
R6526 T22786 T22777 aux could,be
R6527 T22787 T22777 prep due,be
R6528 T22788 T22787 pcomp to,due
R6529 T22789 T22790 det the,expression
R6530 T22790 T22787 pobj expression,due
R6531 T22791 T22790 amod delayed,expression
R6532 T22792 T22791 cc or,delayed
R6533 T22793 T22791 conj weak,delayed
R6534 T22794 T22790 prep of,expression
R6535 T22795 T22796 det the,transgene
R6536 T22796 T22794 pobj transgene,of
R6537 T22797 T22798 compound K14,ΔN87βcat
R6538 T22798 T22796 compound ΔN87βcat,transgene
R6539 T22799 T22798 punct -,ΔN87βcat
R6540 T22800 T22790 prep compared,expression
R6541 T22801 T22800 prep to,compared
R6542 T22802 T22803 det the,promoter
R6543 T22803 T22801 pobj promoter,to
R6544 T22804 T22803 amod intrinsic,promoter
R6545 T22805 T22774 punct .,is
R6546 T22807 T22808 prep In,seen
R6547 T22809 T22807 pobj contrast,In
R6548 T22810 T22808 punct ", ",seen
R6549 T22811 T22812 npadvmod Cre,mediated
R6550 T22812 T22814 amod mediated,recombination
R6551 T22813 T22812 punct -,mediated
R6552 T22814 T22808 nsubjpass recombination,seen
R6553 T22815 T22808 auxpass is,seen
R6554 T22816 T22808 prep in,seen
R6555 T22817 T22818 compound E13.5,skin
R6556 T22818 T22816 pobj skin,in
R6557 T22819 T22818 prep of,skin
R6558 T22820 T22821 nmod K14,cre
R6559 T22821 T22823 nmod cre,mice
R6560 T22822 T22821 punct -,cre
R6561 T22823 T22819 pobj mice,of
R6562 T22824 T22823 amod transgenic,mice
R6563 T22825 T22823 acl used,mice
R6564 T22826 T22825 prep in,used
R6565 T22827 T22828 det this,study
R6566 T22828 T22826 pobj study,in
R6567 T22829 T22830 punct [,16
R6568 T22830 T22808 parataxis 16,seen
R6569 T22831 T22830 punct ],16
R6570 T22832 T22808 cc and,seen
R6571 T22833 T22834 compound K14,cre
R6572 T22834 T22836 npadvmod cre,mediated
R6573 T22835 T22834 punct -,cre
R6574 T22836 T22838 amod mediated,truncation
R6575 T22837 T22836 punct –,mediated
R6576 T22838 T22839 nsubj truncation,is
R6577 T22839 T22808 conj is,seen
R6578 T22840 T22838 prep of,truncation
R6579 T22841 T22842 det the,gene
R6580 T22842 T22840 pobj gene,of
R6581 T22843 T22842 compound Apc,gene
R6582 T22844 T22839 acomp likely,is
R6583 T22845 T22846 aux to,occurred
R6584 T22846 T22844 xcomp occurred,likely
R6585 T22847 T22846 aux have,occurred
R6586 T22848 T22846 prep by,occurred
R6587 T22849 T22848 pcomp then,by
R6588 T22850 T22846 punct ", ",occurred
R6589 T22851 T22846 prep in,occurred
R6590 T22852 T22851 pobj time,in
R6591 T22853 T22852 prep for,time
R6592 T22854 T22855 det the,wave
R6593 T22855 T22853 pobj wave,for
R6594 T22856 T22855 amod second,wave
R6595 T22857 T22855 prep of,wave
R6596 T22858 T22859 compound hair,follicle
R6597 T22859 T22860 compound follicle,morphgenesis
R6598 T22860 T22857 pobj morphgenesis,of
R6599 T22861 T22808 punct .,seen
R6600 T22863 T22864 punct (,2
R6601 T22864 T22865 meta 2,is
R6602 T22866 T22864 punct ),2
R6603 T22867 T22868 det Another,fact
R6604 T22868 T22865 nsubj fact,is
R6605 T22869 T22868 amod important,fact
R6606 T22870 T22871 mark that,confined
R6607 T22871 T22865 ccomp confined,is
R6608 T22872 T22871 prep in,confined
R6609 T22873 T22874 det the,model
R6610 T22874 T22872 pobj model,in
R6611 T22875 T22874 amod aforementioned,model
R6612 T22876 T22874 amod transgenic,model
R6613 T22877 T22878 det the,overexpression
R6614 T22878 T22871 nsubjpass overexpression,confined
R6615 T22879 T22878 prep of,overexpression
R6616 T22880 T22879 pobj transgene,of
R6617 T22881 T22871 auxpass is,confined
R6618 T22882 T22871 prep to,confined
R6619 T22883 T22884 det the,cells
R6620 T22884 T22882 pobj cells,to
R6621 T22885 T22884 amod basal,cells
R6622 T22886 T22884 prep of,cells
R6623 T22887 T22888 det the,epidermis
R6624 T22888 T22886 pobj epidermis,of
R6625 T22889 T22884 cc and,cells
R6626 T22890 T22891 det the,ORS
R6627 T22891 T22884 conj ORS,cells
R6628 T22892 T22891 prep of,ORS
R6629 T22893 T22894 compound hair,follicles
R6630 T22894 T22892 pobj follicles,of
R6631 T22895 T22884 punct ", ",cells
R6632 T22896 T22897 advmod where,is
R6633 T22897 T22884 relcl is,cells
R6634 T22898 T22899 det the,promoter
R6635 T22899 T22897 nsubj promoter,is
R6636 T22900 T22899 compound K14,promoter
R6637 T22901 T22897 acomp active,is
R6638 T22902 T22865 punct .,is
R6639 T22904 T22905 det The,expression
R6640 T22905 T22906 nsubj expression,is
R6641 T22907 T22905 prep of,expression
R6642 T22908 T22907 pobj transgene,of
R6643 T22909 T22906 advmod hence,is
R6644 T22910 T22906 acomp transient,is
R6645 T22911 T22906 cc and,is
R6646 T22912 T22906 conj stops,is
R6647 T22913 T22914 mark once,differentiate
R6648 T22914 T22912 advcl differentiate,stops
R6649 T22915 T22916 npadvmod K14,expressing
R6650 T22916 T22918 amod expressing,cells
R6651 T22917 T22916 punct -,expressing
R6652 T22918 T22914 nsubj cells,differentiate
R6653 T22919 T22914 advmod terminally,differentiate
R6654 T22920 T22906 punct .,is
R6655 T22922 T22923 prep In,result
R6656 T22924 T22922 pobj contrast,In
R6657 T22925 T22923 punct ", ",result
R6658 T22926 T22923 prep in,result
R6659 T22927 T22928 poss our,model
R6660 T22928 T22926 pobj model,in
R6661 T22929 T22923 punct ", ",result
R6662 T22930 T22931 compound K14,cre
R6663 T22931 T22933 npadvmod cre,mediated
R6664 T22932 T22931 punct -,cre
R6665 T22933 T22935 amod mediated,deletion
R6666 T22934 T22933 punct –,mediated
R6667 T22935 T22923 nsubj deletion,result
R6668 T22936 T22935 prep of,deletion
R6669 T22937 T22936 pobj Apc,of
R6670 T22938 T22923 aux would,result
R6671 T22939 T22923 prep in,result
R6672 T22940 T22941 compound Apc,mutation
R6673 T22941 T22939 pobj mutation,in
R6674 T22942 T22943 preconj not,in
R6675 T22943 T22923 prep in,result
R6676 T22944 T22942 advmod only,not
R6677 T22945 T22946 nmod K14,cells
R6678 T22946 T22943 pobj cells,in
R6679 T22947 T22946 nmod promoter,cells
R6680 T22948 T22946 amod active,cells
R6681 T22949 T22923 punct ", ",result
R6682 T22950 T22923 cc but,result
R6683 T22951 T22923 conj remain,result
R6684 T22952 T22951 advmod so,remain
R6685 T22953 T22951 prep in,remain
R6686 T22954 T22955 det all,layers
R6687 T22955 T22953 pobj layers,in
R6688 T22956 T22955 compound cell,layers
R6689 T22957 T22958 dep that,derived
R6690 T22958 T22955 relcl derived,layers
R6691 T22959 T22958 prep from,derived
R6692 T22960 T22961 det the,progenitors
R6693 T22961 T22959 pobj progenitors,from
R6694 T22962 T22963 nmod K14,promoter
R6695 T22963 T22961 nmod promoter,progenitors
R6696 T22964 T22961 amod active,progenitors
R6697 T22965 T22923 punct .,result
R6698 T22967 T22968 det These,derivatives
R6699 T22968 T22969 nsubj derivatives,include
R6700 T22970 T22971 det the,epidermis
R6701 T22971 T22969 dobj epidermis,include
R6702 T22972 T22971 amod suprabasal,epidermis
R6703 T22973 T22971 cc and,epidermis
R6704 T22974 T22975 det the,epithelium
R6705 T22975 T22971 conj epithelium,epidermis
R6706 T22976 T22975 amod entire,epithelium
R6707 T22977 T22975 prep of,epithelium
R6708 T22978 T22979 det the,follicle
R6709 T22979 T22977 pobj follicle,of
R6710 T22980 T22979 compound hair,follicle
R6711 T22981 T22969 punct .,include
R6712 T22983 T22984 nsubj Stabilization,account
R6713 T22985 T22983 prep of,Stabilization
R6714 T22986 T22987 compound β,catenin
R6715 T22987 T22985 pobj catenin,of
R6716 T22988 T22987 punct -,catenin
R6717 T22989 T22983 prep in,Stabilization
R6718 T22990 T22991 det a,population
R6719 T22991 T22989 pobj population,in
R6720 T22992 T22991 amod broader,population
R6721 T22993 T22991 prep of,population
R6722 T22994 T22993 pobj cells,of
R6723 T22995 T22984 aux could,account
R6724 T22996 T22984 prep for,account
R6725 T22997 T22996 pobj some,for
R6726 T22998 T22997 prep of,some
R6727 T22999 T23000 det the,differences
R6728 T23000 T22998 pobj differences,of
R6729 T23001 T23000 amod phenotypic,differences
R6730 T23002 T22984 punct .,account
R6731 T23004 T23005 advmod However,detect
R6732 T23006 T23005 punct ", ",detect
R6733 T23007 T23005 nsubj we,detect
R6734 T23008 T23005 aux did,detect
R6735 T23009 T23005 neg not,detect
R6736 T23010 T23011 det any,expression
R6737 T23011 T23005 dobj expression,detect
R6738 T23012 T23011 amod elevated,expression
R6739 T23013 T23014 compound β,catenin
R6740 T23014 T23011 compound catenin,expression
R6741 T23015 T23014 punct -,catenin
R6742 T23016 T23005 prep in,detect
R6743 T23017 T23018 preconj either,cells
R6744 T23018 T23016 pobj cells,in
R6745 T23019 T23020 npadvmod K1,positive
R6746 T23020 T23018 amod positive,cells
R6747 T23021 T23019 punct -,K1
R6748 T23022 T23019 cc or,K1
R6749 T23023 T23019 conj K6,K1
R6750 T23024 T23020 punct -,positive
R6751 T23025 T23018 amod differentiated,cells
R6752 T23026 T23005 prep in,detect
R6753 T23027 T23028 amod postnatal,skin
R6754 T23028 T23026 pobj skin,in
R6755 T23029 T23028 amod mutant,skin
R6756 T23030 T23005 punct .,detect
R6757 T23032 T23033 nsubj This,indicates
R6758 T23034 T23035 mark that,take
R6759 T23035 T23033 ccomp take,indicates
R6760 T23036 T23035 prep despite,take
R6761 T23037 T23038 det the,absence
R6762 T23038 T23036 pobj absence,despite
R6763 T23039 T23038 prep of,absence
R6764 T23040 T23039 pobj Apc,of
R6765 T23041 T23038 cc and,absence
R6766 T23042 T23043 amod potential,stabilization
R6767 T23043 T23038 conj stabilization,absence
R6768 T23044 T23043 prep of,stabilization
R6769 T23045 T23046 compound β,catenin
R6770 T23046 T23044 pobj catenin,of
R6771 T23047 T23046 punct -,catenin
R6772 T23048 T23038 prep in,absence
R6773 T23049 T23048 pobj derivatives,in
R6774 T23050 T23049 prep of,derivatives
R6775 T23051 T23052 npadvmod K14,expressing
R6776 T23052 T23054 amod expressing,progenitors
R6777 T23053 T23052 punct -,expressing
R6778 T23054 T23050 pobj progenitors,of
R6779 T23055 T23035 punct ", ",take
R6780 T23056 T23057 amod elevated,expression
R6781 T23057 T23035 nsubj expression,take
R6782 T23058 T23059 compound β,catenin
R6783 T23059 T23057 compound catenin,expression
R6784 T23060 T23059 punct -,catenin
R6785 T23061 T23057 punct ", ",expression
R6786 T23062 T23057 cc and,expression
R6787 T23063 T23064 amod subsequent,determination
R6788 T23064 T23057 conj determination,expression
R6789 T23065 T23066 compound cell,fate
R6790 T23066 T23064 compound fate,determination
R6791 T23067 T23035 aux may,take
R6792 T23068 T23035 advmod only,take
R6793 T23069 T23035 dobj place,take
R6794 T23070 T23035 prep in,take
R6795 T23071 T23072 amod basal,cells
R6796 T23072 T23070 pobj cells,in
R6797 T23073 T23033 punct .,indicates
R6798 T23075 T23076 punct (,3
R6799 T23076 T23077 meta 3,exclude
R6800 T23078 T23076 punct ),3
R6801 T23079 T23077 nsubj We,exclude
R6802 T23080 T23077 aux can,exclude
R6803 T23081 T23077 neg not,exclude
R6804 T23082 T23083 det the,possibility
R6805 T23083 T23077 dobj possibility,exclude
R6806 T23084 T23085 mark that,contributed
R6807 T23085 T23083 acl contributed,possibility
R6808 T23086 T23085 prep given,contributed
R6809 T23087 T23088 det the,properties
R6810 T23088 T23086 pobj properties,given
R6811 T23089 T23088 amod multifunctional,properties
R6812 T23090 T23088 prep of,properties
R6813 T23091 T23090 pobj Apc,of
R6814 T23092 T23085 punct ", ",contributed
R6815 T23093 T23085 nsubj disruption,contributed
R6816 T23094 T23093 prep of,disruption
R6817 T23095 T23096 poss its,functions
R6818 T23096 T23094 pobj functions,of
R6819 T23097 T23096 amod other,functions
R6820 T23098 T23097 prep than,other
R6821 T23099 T23100 advmod down,regulation
R6822 T23100 T23098 pobj regulation,than
R6823 T23101 T23100 punct -,regulation
R6824 T23102 T23100 prep of,regulation
R6825 T23103 T23104 compound β,catenin
R6826 T23104 T23102 pobj catenin,of
R6827 T23105 T23104 punct -,catenin
R6828 T23106 T23085 aux may,contributed
R6829 T23107 T23085 advmod also,contributed
R6830 T23108 T23085 aux have,contributed
R6831 T23109 T23085 prep to,contributed
R6832 T23110 T23111 det the,phenotype
R6833 T23111 T23109 pobj phenotype,to
R6834 T23112 T23111 amod observed,phenotype
R6835 T23113 T23111 amod overt,phenotype
R6836 T23114 T23077 punct .,exclude
R6837 T23116 T23117 mark While,were
R6838 T23117 T23124 advcl were,were
R6839 T23118 T23119 det some,features
R6840 T23119 T23117 nsubj features,were
R6841 T23120 T23119 prep of,features
R6842 T23121 T23122 poss our,mice
R6843 T23122 T23120 pobj mice,of
R6844 T23123 T23122 amod mutant,mice
R6845 T23125 T23117 acomp similar,were
R6846 T23126 T23125 prep to,similar
R6847 T23127 T23128 det these,mice
R6848 T23128 T23126 pobj mice,to
R6849 T23129 T23128 amod transgenic,mice
R6850 T23130 T23124 punct ", ",were
R6851 T23131 T23132 amod other,aspects
R6852 T23132 T23124 nsubj aspects,were
R6853 T23133 T23132 amod phenotypic,aspects
R6854 T23134 T23135 advmod largely,distinct
R6855 T23135 T23124 acomp distinct,were
R6856 T23136 T23124 punct .,were
R6857 T23138 T23139 prep In,caused
R6858 T23140 T23138 pobj addition,In
R6859 T23141 T23140 prep to,addition
R6860 T23142 T23143 amod aberrant,morphogenesis
R6861 T23143 T23141 pobj morphogenesis,to
R6862 T23144 T23145 compound hair,follicle
R6863 T23145 T23143 compound follicle,morphogenesis
R6864 T23146 T23139 punct ", ",caused
R6865 T23147 T23148 npadvmod K14,driven
R6866 T23148 T23150 amod driven,loss
R6867 T23149 T23148 punct -,driven
R6868 T23150 T23139 nsubj loss,caused
R6869 T23151 T23150 prep of,loss
R6870 T23152 T23151 pobj Apc,of
R6871 T23153 T23139 dobj formation,caused
R6872 T23154 T23153 prep of,formation
R6873 T23155 T23156 amod multiple,buds
R6874 T23156 T23154 pobj buds,of
R6875 T23157 T23156 compound tooth,buds
R6876 T23158 T23159 dep that,known
R6877 T23159 T23156 relcl known,buds
R6878 T23160 T23159 punct ", ",known
R6879 T23161 T23159 prep like,known
R6880 T23162 T23163 compound hair,follicles
R6881 T23163 T23161 pobj follicles,like
R6882 T23164 T23159 punct ", ",known
R6883 T23165 T23159 auxpass were,known
R6884 T23166 T23167 aux to,develop
R6885 T23167 T23159 xcomp develop,known
R6886 T23168 T23167 prep through,develop
R6887 T23169 T23170 amod inductive,interactions
R6888 T23170 T23168 pobj interactions,through
R6889 T23171 T23170 prep between,interactions
R6890 T23172 T23173 det the,epithelium
R6891 T23173 T23171 pobj epithelium,between
R6892 T23174 T23173 cc and,epithelium
R6893 T23175 T23173 conj mesenchyme,epithelium
R6894 T23176 T23139 punct .,caused
R6895 T23178 T23179 det This,observation
R6896 T23179 T23180 nsubj observation,was
R6897 T23181 T23180 acomp similar,was
R6898 T23182 T23181 prep to,similar
R6899 T23183 T23184 det the,buds
R6900 T23184 T23182 pobj buds,to
R6901 T23185 T23184 amod ectopic,buds
R6902 T23186 T23184 compound tooth,buds
R6903 T23187 T23184 acl found,buds
R6904 T23188 T23187 prep in,found
R6905 T23189 T23188 pobj animals,in
R6906 T23190 T23189 acl misexpressing,animals
R6907 T23191 T23190 dobj Lef1,misexpressing
R6908 T23192 T23193 punct [,27
R6909 T23193 T23187 parataxis 27,found
R6910 T23194 T23193 punct ],27
R6911 T23195 T23181 punct ", ",similar
R6912 T23196 T23181 cc but,similar
R6913 T23197 T23198 advmod more,severe
R6914 T23198 T23181 conj severe,similar
R6915 T23199 T23180 cc and,was
R6916 T23200 T23180 conj was,was
R6917 T23201 T23200 advmod also,was
R6918 T23202 T23200 acomp present,was
R6919 T23203 T23200 prep at,was
R6920 T23204 T23203 pobj birth,at
R6921 T23205 T23200 punct ", ",was
R6922 T23206 T23200 advcl indicating,was
R6923 T23207 T23208 det the,effect
R6924 T23208 T23206 dobj effect,indicating
R6925 T23209 T23208 prep of,effect
R6926 T23210 T23211 compound Apc,loss
R6927 T23211 T23209 pobj loss,of
R6928 T23212 T23211 prep during,loss
R6929 T23213 T23214 det the,initiation
R6930 T23214 T23212 pobj initiation,during
R6931 T23215 T23214 prep of,initiation
R6932 T23216 T23217 amod embryonic,development
R6933 T23217 T23215 pobj development,of
R6934 T23218 T23217 compound tooth,development
R6935 T23219 T23208 punct ", ",effect
R6936 T23220 T23221 dep which,was
R6937 T23221 T23208 relcl was,effect
R6938 T23222 T23221 acomp evident,was
R6939 T23223 T23221 prep by,was
R6940 T23224 T23225 amod aberrant,expression
R6941 T23225 T23223 pobj expression,by
R6942 T23226 T23225 compound Shh,expression
R6943 T23227 T23225 prep in,expression
R6944 T23228 T23229 nmod E15.5,epithelium
R6945 T23229 T23227 pobj epithelium,in
R6946 T23230 T23229 amod embryonic,epithelium
R6947 T23231 T23229 amod oral,epithelium
R6948 T23232 T23233 punct (,data
R6949 T23233 T23206 meta data,indicating
R6950 T23234 T23233 amod unpublished,data
R6951 T23235 T23233 punct ),data
R6952 T23236 T23180 punct .,was
R6953 T23238 T23239 nsubjpass It,noted
R6954 T23240 T23239 aux should,noted
R6955 T23241 T23239 auxpass be,noted
R6956 T23242 T23243 mark that,broke
R6957 T23243 T23239 ccomp broke,noted
R6958 T23244 T23245 mark although,were
R6959 T23245 T23243 advcl were,broke
R6960 T23246 T23247 amod multiple,buds
R6961 T23247 T23245 nsubj buds,were
R6962 T23248 T23247 compound tooth,buds
R6963 T23249 T23250 advmod histologically,visible
R6964 T23250 T23245 acomp visible,were
R6965 T23251 T23252 punct (,4O
R6966 T23252 T23245 parataxis 4O,were
R6967 T23253 T23252 compound Figure,4O
R6968 T23254 T23252 cc and,4O
R6969 T23255 T23252 conj 4P,4O
R6970 T23256 T23252 punct ),4O
R6971 T23257 T23243 punct ", ",broke
R6972 T23258 T23259 det these,teeth
R6973 T23259 T23243 nsubj teeth,broke
R6974 T23260 T23243 neg never,broke
R6975 T23261 T23243 prt out,broke
R6976 T23262 T23243 cc and,broke
R6977 T23263 T23264 det the,mice
R6978 T23264 T23267 nsubj mice,appeared
R6979 T23265 T23264 nmod KA,mice
R6980 T23266 T23264 amod mutant,mice
R6981 T23267 T23243 conj appeared,broke
R6982 T23268 T23267 oprd toothless,appeared
R6983 T23375 T23373 pobj consequence,as
R6984 T23376 T23375 prep of,consequence
R6985 T23377 T23378 amod poor,nutrition
R6986 T23378 T23376 pobj nutrition,of
R6987 T23379 T23378 acl caused,nutrition
R6988 T23380 T23379 agent by,caused
R6989 T23381 T23382 det the,absence
R6990 T23269 T23239 punct .,noted
R6991 T23382 T23380 pobj absence,by
R6992 T23383 T23382 prep of,absence
R6993 T23271 T23272 det This,defect
R6994 T23384 T23383 pobj teeth,of
R6995 T23385 T23365 punct .,reduced
R6996 T23272 T23276 nsubj defect,is
R6997 T23273 T23272 amod unusual,defect
R6998 T23387 T23388 mark Since,started
R6999 T23274 T23272 amod severe,defect
R7000 T23275 T23272 compound tooth,defect
R7001 T23388 T23395 advcl started,be
R7002 T23277 T23276 acomp unique,is
R7003 T23278 T23277 prep to,unique
R7004 T23279 T23280 det these,mice
R7005 T23389 T23390 det the,loss
R7006 T23280 T23278 pobj mice,to
R7007 T23281 T23280 amod mutant,mice
R7008 T23390 T23388 nsubj loss,started
R7009 T23282 T23276 punct .,is
R7010 T23284 T23285 prep In,was
R7011 T23391 T23390 compound weight,loss
R7012 T23392 T23390 prep in,loss
R7013 T23286 T23284 pobj addition,In
R7014 T23287 T23285 punct ", ",was
R7015 T23393 T23394 compound KA,mutants
R7016 T23288 T23285 nsubj neither,was
R7017 T23289 T23288 prep of,neither
R7018 T23290 T23291 det the,mice
R7019 T23394 T23392 pobj mutants,in
R7020 T23291 T23289 pobj mice,of
R7021 T23292 T23291 nummod two,mice
R7022 T23293 T23291 amod transgenic,mice
R7023 T23396 T23388 prep from,started
R7024 T23294 T23295 advmod postnatally,lethal
R7025 T23295 T23285 acomp lethal,was
R7026 T23296 T23285 prep as,was
R7027 T23297 T23296 prep in,as
R7028 T23298 T23299 det the,mice
R7029 T23299 T23297 pobj mice,in
R7030 T23397 T23396 pobj P8,from
R7031 T23300 T23299 nmod KA,mice
R7032 T23301 T23299 amod mutant,mice
R7033 T23302 T23285 punct .,was
R7034 T23398 T23399 punct –,P10
R7035 T23399 T23397 prep P10,P8
R7036 T23304 T23305 nsubj We,find
R7037 T23306 T23305 aux did,find
R7038 T23307 T23305 neg not,find
R7039 T23308 T23309 det any,abnormalities
R7040 T23400 T23401 mark while,nursed
R7041 T23309 T23305 dobj abnormalities,find
R7042 T23310 T23309 amod obvious,abnormalities
R7043 T23311 T23309 amod histopathological,abnormalities
R7044 T23312 T23309 prep in,abnormalities
R7045 T23401 T23388 advcl nursed,started
R7046 T23313 T23314 det the,organs
R7047 T23314 T23312 pobj organs,in
R7048 T23315 T23314 amod internal,organs
R7049 T23402 T23401 nsubjpass pups,nursed
R7050 T23316 T23314 prep of,organs
R7051 T23317 T23318 compound KA,mice
R7052 T23318 T23316 pobj mice,of
R7053 T23403 T23401 auxpass were,nursed
R7054 T23319 T23320 dep that,contribute
R7055 T23320 T23309 relcl contribute,abnormalities
R7056 T23321 T23320 aux could,contribute
R7057 T23404 T23401 advmod still,nursed
R7058 T23322 T23320 prep to,contribute
R7059 T23323 T23324 det the,lethality
R7060 T23405 T23401 agent by,nursed
R7061 T23324 T23322 pobj lethality,to
R7062 T23325 T23305 punct .,find
R7063 T23406 T23407 poss their,mothers
R7064 T23327 T23328 advmod However,indicates
R7065 T23407 T23405 pobj mothers,by
R7066 T23329 T23328 punct ", ",indicates
R7067 T23330 T23331 det the,fact
R7068 T23331 T23328 nsubj fact,indicates
R7069 T23408 T23395 punct ", ",be
R7070 T23332 T23333 mark that,had
R7071 T23333 T23331 acl had,fact
R7072 T23334 T23335 predet all,mutants
R7073 T23409 T23395 nsubj starvation,be
R7074 T23335 T23333 nsubj mutants,had
R7075 T23336 T23335 det the,mutants
R7076 T23337 T23338 amod lower,weight
R7077 T23338 T23333 dobj weight,had
R7078 T23339 T23340 punct (,2F
R7079 T23340 T23338 parataxis 2F,weight
R7080 T23410 T23409 prep due,starvation
R7081 T23341 T23340 compound Figure,2F
R7082 T23342 T23340 punct ),2F
R7083 T23343 T23338 prep with,weight
R7084 T23411 T23410 pcomp to,due
R7085 T23344 T23345 advmod hardly,evidence
R7086 T23345 T23343 pobj evidence,with
R7087 T23412 T23410 pobj lack,due
R7088 T23346 T23345 det any,evidence
R7089 T23347 T23345 prep of,evidence
R7090 T23348 T23349 amod solid,food
R7091 T23349 T23347 pobj food,of
R7092 T23413 T23412 prep of,lack
R7093 T23350 T23345 prep in,evidence
R7094 T23351 T23352 poss their,stomach
R7095 T23352 T23350 pobj stomach,in
R7096 T23414 T23413 pobj teeth,of
R7097 T23353 T23354 mark that,died
R7098 T23354 T23328 ccomp died,indicates
R7099 T23355 T23356 det the,mutants
R7100 T23415 T23395 aux can,be
R7101 T23356 T23354 nsubj mutants,died
R7102 T23357 T23354 aux might,died
R7103 T23358 T23354 aux have,died
R7104 T23416 T23395 neg not,be
R7105 T23359 T23354 prep of,died
R7106 T23360 T23359 pobj starvation,of
R7107 T23361 T23328 punct .,indicates
R7108 T23417 T23418 det the,cause
R7109 T23418 T23395 attr cause,be
R7110 T23363 T23364 amod Dermal,fat
R7111 T23419 T23418 amod sole,cause
R7112 T23364 T23365 nsubjpass fat,reduced
R7113 T23420 T23418 prep of,cause
R7114 T23366 T23365 auxpass was,reduced
R7115 T23367 T23365 prep in,reduced
R7116 T23421 T23420 pobj death,of
R7117 T23368 T23369 det the,skin
R7118 T23369 T23367 pobj skin,in
R7119 T23370 T23369 amod mutant,skin
R7120 T23422 T23395 punct ", ",be
R7121 T23371 T23365 punct ", ",reduced
R7122 T23372 T23373 advmod possibly,as
R7123 T23423 T23395 cc but,be
R7124 T23373 T23365 prep as,reduced
R7125 T23374 T23375 det a,consequence
R7126 T23424 T23395 conj is,be
R7127 T23425 T23424 acomp likely,is
R7128 T23426 T23427 aux to,be
R7129 T23427 T23425 xcomp be,likely
R7130 T23428 T23429 det a,factor
R7131 T23481 T23482 compound bud,formation
R7132 T23482 T23479 pobj formation,of
R7133 T23483 T23484 amod proper,development
R7134 T23429 T23427 attr factor,be
R7135 T23484 T23473 dobj development,allows
R7136 T23485 T23484 prep of,development
R7137 T23486 T23485 pobj teeth,of
R7138 T23430 T23429 amod contributing,factor
R7139 T23487 T23488 mark for,have
R7140 T23488 T23473 advcl have,allows
R7141 T23489 T23488 nsubj mice,have
R7142 T23431 T23395 punct .,be
R7143 T23490 T23488 aux to,have
R7144 T23491 T23492 det a,diet
R7145 T23433 T23434 nsubjpass Absence,observed
R7146 T23492 T23488 dobj diet,have
R7147 T23493 T23492 amod healthy,diet
R7148 T23494 T23492 cc and,diet
R7149 T23435 T23433 prep of,Absence
R7150 T23495 T23496 amod normal,life
R7151 T23496 T23492 conj life,diet
R7152 T23497 T23473 punct .,allows
R7153 T23499 T23500 amod Mechanistic,studies
R7154 T23436 T23435 pobj teeth,of
R7155 T23500 T23501 nsubj studies,are
R7156 T23437 T23436 cc and,teeth
R7157 T23502 T23503 aux to,understand
R7158 T23503 T23500 advcl understand,studies
R7159 T23504 T23505 advmod how,leads
R7160 T23438 T23439 amod mammary,glands
R7161 T23505 T23503 ccomp leads,understand
R7162 T23506 T23507 amod increased,levels
R7163 T23507 T23505 nsubj levels,leads
R7164 T23439 T23436 conj glands,teeth
R7165 T23508 T23507 prep of,levels
R7166 T23509 T23510 compound β,catenin
R7167 T23440 T23434 aux have,observed
R7168 T23510 T23508 pobj catenin,of
R7169 T23511 T23510 punct -,catenin
R7170 T23512 T23505 prep to,leads
R7171 T23441 T23434 auxpass been,observed
R7172 T23513 T23514 amod altered,phenotypes
R7173 T23514 T23512 pobj phenotypes,to
R7174 T23515 T23514 nmod skin,phenotypes
R7175 T23442 T23434 prep in,observed
R7176 T23516 T23515 cc and,skin
R7177 T23517 T23515 conj tooth,skin
R7178 T23518 T23501 prep under,are
R7179 T23443 T23442 pobj mice,in
R7180 T23519 T23518 pobj way,under
R7181 T23520 T23501 punct .,are
R7182 T23444 T23443 amod deficient,mice
R7183 T23445 T23444 prep in,deficient
R7184 T23446 T23445 pobj Lef1,in
R7185 T23447 T23444 cc and,deficient
R7186 T23448 T23449 advmod ectopically,expressing
R7187 T23449 T23444 conj expressing,deficient
R7188 T23450 T23449 dobj Dkk1,expressing
R7189 T23451 T23452 punct [,30
R7190 T23452 T23434 parataxis 30,observed
R7191 T23453 T23452 nummod 29,30
R7192 T23454 T23452 punct ",",30
R7193 T23455 T23452 punct ],30
R7194 T23456 T23434 cc but,observed
R7195 T23457 T23458 poss their,absence
R7196 T23458 T23459 nsubj absence,was
R7197 T23459 T23434 conj was,observed
R7198 T23460 T23459 prep due,was
R7199 T23461 T23460 pcomp to,due
R7200 T23462 T23463 det the,block
R7201 T23463 T23460 pobj block,due
R7202 T23464 T23463 prep in,block
R7203 T23465 T23464 pobj development,in
R7204 T23466 T23463 prep before,block
R7205 T23467 T23468 det the,stage
R7206 T23468 T23466 pobj stage,before
R7207 T23469 T23468 compound bud,stage
R7208 T23470 T23459 punct .,was
R7209 T23472 T23473 advmod Hence,allows
R7210 T23474 T23473 punct ", ",allows
R7211 T23475 T23476 preconj neither,loss
R7212 T23476 T23473 nsubj loss,allows
R7213 T23477 T23476 cc nor,loss
R7214 T23478 T23476 conj excess,loss
R7215 T23479 T23476 prep of,loss
R7216 T23480 T23481 amod tooth,bud

2_test

Id Subject Object Predicate Lexical cue
17002498-11841536-85593519 304-306 11841536 denotes 24
17002498-9845363-85593520 686-688 9845363 denotes 25
17002498-10409498-85593520 686-688 10409498 denotes 25
17002498-7537238-85593520 686-688 7537238 denotes 25
17002498-11371349-85593521 926-928 11371349 denotes 28
17002498-12015971-85593521 926-928 12015971 denotes 28
17002498-7958926-85593521 926-928 7958926 denotes 28
17002498-9845363-85593522 1970-1972 9845363 denotes 25
17002498-7537238-85593523 2004-2006 7537238 denotes 27
17002498-7525178-85593524 2781-2783 7525178 denotes 19
17002498-8990189-85593525 2784-2786 8990189 denotes 31
17002498-11694875-85593526 3421-3423 11694875 denotes 16
17002498-7537238-85593527 5370-5372 7537238 denotes 27
17002498-12015971-85593528 6706-6708 12015971 denotes 29
17002498-7958926-85593529 6709-6711 7958926 denotes 30
T58138 304-306 11841536 denotes 24
T2579 686-688 9845363 denotes 25
T26992 686-688 10409498 denotes 25
T7229 686-688 7537238 denotes 25
T24052 926-928 11371349 denotes 28
T27200 926-928 12015971 denotes 28
T60441 926-928 7958926 denotes 28
T55311 1970-1972 9845363 denotes 25
T47275 2004-2006 7537238 denotes 27
T44354 2781-2783 7525178 denotes 19
T70725 2784-2786 8990189 denotes 31
T26365 3421-3423 11694875 denotes 16
T95890 5370-5372 7537238 denotes 27
T41351 6706-6708 12015971 denotes 29
T13746 6709-6711 7958926 denotes 30