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normal thymus is a lobulated lymphoid organ, each lobule clearly showing the two distinct TEC compartments, an outer cortex and an inner medulla (Figure 6). There were no major differences in the histology of thymus between the ages P3 to P17 in phenotypically normal littermates. As shown in the H\u0026E staining of thymus, the cortex was formed of dense lymphoid tissue that lacks nodules (Figure 6A). Since the stroma of the medulla is less heavily infiltrated with lymphocytes than the cortex, the medulla stained more lightly than the cortex. In normal mice, the thymus retains its size until the young adult age and regresses thereafter by atrophy. In the normal young mice we examined (P3–P17), it is evident that thymocytes were mitotically active in the cortex as determined by BrdU immunostaining (Figure 6B). Immunohistochemistry of normal thymus from P3 to P17 mice showed a similar staining pattern for K14 in that its expression was restricted to a small population of TECs in the inner medullary region and in the keratinocytes in Hassall's corpuscles (Figure 6D). Diffuse cytoplasmic staining for β-catenin was also detected in the medullary epithelial cells (Figure 6C). In contrast to K14 expression, diffuse staining for K8 was observed in epithelial cells both in the medulla and cortex (Figure S3). K1 staining was not detected in young mice at P3 but in older mice it was detected in differentiated keratinocytes in some of Hassall's corpuscles (Figure S3)."}