PMC:1564426 / 13915-15245 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1564426","sourcedb":"PMC","sourceid":"1564426","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1564426","text":"Figure 2 Postnatal Mortality and Stunted Growth in K14-cre; ApcCKO/CKO Mutant Mice\nAnimals whose genotype is either heterozygous or homozygous for the wild-type Apc allele are referred to as normal (N); those whose genotype are K14-cre; ApcCKO/CKO and show the presence of K14-cre–recombined mutant Apc allele are called mutant (M).\n(A) Two P3 mutant mice, M1 and M2, and their normal littermates, showing size variation among mutants.\n(B) P8 mutant mouse (right) and a normal littermate. Note sparseness of hair coat and abnormal ears.\n(C–D) Vibrissae of whisker pads are short and oddly angled in a P12 mutant mouse (C), relative to control (D). Note the lack of incisors in the mutant.\n(E) A P17 mutant mouse (right) with its littermate. Its bare forehead, dorsal median line, and abnormal ears are evident.\n(F) Growth curve of mutants and normal littermates. Mutants exhibit stunted growth, which became more prominent as they aged, and weigh significantly less than littermates from P8 (p \u003c 0.05).\n(G) Comparison of mutant and normal thymus from P3 mice. The mutant thymus (left) is dramatically smaller for its age compared to the normal littermate (right). The scale bar equals 1 mm.\n(H) Skeletal preparations of normal (left) and mutant (right), showing differences in development of both incisor (I) and molar (M) teeth.","divisions":[{"label":"label","span":{"begin":0,"end":8}},{"label":"title","span":{"begin":10,"end":83}},{"label":"p","span":{"begin":84,"end":333}},{"label":"p","span":{"begin":334,"end":436}},{"label":"p","span":{"begin":437,"end":537}},{"label":"p","span":{"begin":538,"end":689}},{"label":"p","span":{"begin":690,"end":811}},{"label":"p","span":{"begin":812,"end":1003}},{"label":"p","span":{"begin":1004,"end":1191}}],"tracks":[]}