PMC:1540739 / 388-760 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T506","span":{"begin":10,"end":19},"obj":"VBD"},{"id":"T510","span":{"begin":0,"end":5},"obj":"NN"},{"id":"T512","span":{"begin":5,"end":7},"obj":","},{"id":"T513","span":{"begin":7,"end":9},"obj":"PRP"},{"id":"T514","span":{"begin":20,"end":22},"obj":"DT"},{"id":"T515","span":{"begin":78,"end":84},"obj":"NN"},{"id":"T516","span":{"begin":23,"end":31},"obj":"VBN"},{"id":"T517","span":{"begin":32,"end":43},"obj":"NN"},{"id":"T518","span":{"begin":44,"end":52},"obj":"JJ"},{"id":"T519","span":{"begin":43,"end":44},"obj":"HYPH"},{"id":"T520","span":{"begin":62,"end":70},"obj":"NNP"},{"id":"T521","span":{"begin":53,"end":61},"obj":"NNP"},{"id":"T522","span":{"begin":71,"end":72},"obj":"-LRB-"},{"id":"T523","span":{"begin":72,"end":76},"obj":"NN"},{"id":"T524","span":{"begin":76,"end":77},"obj":"-RRB-"},{"id":"T525","span":{"begin":84,"end":85},"obj":"."},{"id":"T526","span":{"begin":85,"end":183},"obj":"sentence"},{"id":"T527","span":{"begin":86,"end":89},"obj":"PRP$"},{"id":"T528","span":{"begin":90,"end":98},"obj":"NN"},{"id":"T529","span":{"begin":99,"end":106},"obj":"VBZ"},{"id":"T530","span":{"begin":107,"end":116},"obj":"JJ"},{"id":"T531","span":{"begin":117,"end":126},"obj":"NN"},{"id":"T532","span":{"begin":127,"end":129},"obj":"IN"},{"id":"T533","span":{"begin":130,"end":132},"obj":"NN"},{"id":"T534","span":{"begin":133,"end":138},"obj":"NNS"},{"id":"T535","span":{"begin":139,"end":141},"obj":"TO"},{"id":"T536","span":{"begin":142,"end":152},"obj":"VB"},{"id":"T537","span":{"begin":153,"end":156},"obj":"DT"},{"id":"T538","span":{"begin":157,"end":167},"obj":"NN"},{"id":"T539","span":{"begin":168,"end":170},"obj":"IN"},{"id":"T540","span":{"begin":171,"end":177},"obj":"JJ"},{"id":"T541","span":{"begin":178,"end":182},"obj":"NNS"},{"id":"T542","span":{"begin":182,"end":183},"obj":"."},{"id":"T543","span":{"begin":183,"end":300},"obj":"sentence"},{"id":"T544","span":{"begin":184,"end":187},"obj":"CC"},{"id":"T545","span":{"begin":223,"end":230},"obj":"VBN"},{"id":"T546","span":{"begin":188,"end":192},"obj":"RBR"},{"id":"T547","span":{"begin":193,"end":204},"obj":"RB"},{"id":"T548","span":{"begin":204,"end":206},"obj":","},{"id":"T549","span":{"begin":206,"end":209},"obj":"DT"},{"id":"T550","span":{"begin":210,"end":218},"obj":"NN"},{"id":"T551","span":{"begin":219,"end":222},"obj":"VBD"},{"id":"T552","span":{"begin":231,"end":234},"obj":"IN"},{"id":"T553","span":{"begin":235,"end":244},"obj":"NN"},{"id":"T554","span":{"begin":245,"end":247},"obj":"IN"},{"id":"T555","span":{"begin":248,"end":255},"obj":"JJ"},{"id":"T556","span":{"begin":256,"end":261},"obj":"NNS"},{"id":"T557","span":{"begin":262,"end":264},"obj":"TO"},{"id":"T558","span":{"begin":265,"end":275},"obj":"VB"},{"id":"T559","span":{"begin":276,"end":287},"obj":"NN"},{"id":"T560","span":{"begin":288,"end":289},"obj":"-LRB-"},{"id":"T561","span":{"begin":289,"end":293},"obj":"NN"},{"id":"T562","span":{"begin":294,"end":298},"obj":"NN"},{"id":"T563","span":{"begin":293,"end":294},"obj":"HYPH"},{"id":"T564","span":{"begin":298,"end":299},"obj":"-RRB-"},{"id":"T565","span":{"begin":299,"end":300},"obj":"."},{"id":"T567","span":{"begin":301,"end":303},"obj":"PRP"},{"id":"T568","span":{"begin":304,"end":311},"obj":"VBP"},{"id":"T569","span":{"begin":312,"end":317},"obj":"NN"},{"id":"T570","span":{"begin":317,"end":318},"obj":"HYPH"},{"id":"T571","span":{"begin":318,"end":320},"obj":"IN"},{"id":"T572","span":{"begin":320,"end":321},"obj":"HYPH"},{"id":"T573","span":{"begin":321,"end":328},"obj":"NN"},{"id":"T574","span":{"begin":329,"end":332},"obj":"IN"},{"id":"T575","span":{"begin":333,"end":337},"obj":"DT"},{"id":"T576","span":{"begin":338,"end":340},"obj":"IN"},{"id":"T577","span":{"begin":341,"end":344},"obj":"DT"},{"id":"T578","span":{"begin":349,"end":354},"obj":"NN"},{"id":"T579","span":{"begin":345,"end":348},"obj":"NN"},{"id":"T580","span":{"begin":354,"end":356},"obj":","},{"id":"T581","span":{"begin":356,"end":358},"obj":"IN"},{"id":"T582","span":{"begin":359,"end":366},"obj":"VBG"}],"relations":[{"id":"R67","pred":"punct","subj":"T512","obj":"T506"},{"id":"R68","pred":"nsubj","subj":"T513","obj":"T506"},{"id":"R69","pred":"det","subj":"T514","obj":"T515"},{"id":"R70","pred":"dobj","subj":"T515","obj":"T506"},{"id":"R71","pred":"amod","subj":"T516","obj":"T515"},{"id":"R72","pred":"npadvmod","subj":"T517","obj":"T518"},{"id":"R73","pred":"amod","subj":"T518","obj":"T520"},{"id":"R74","pred":"punct","subj":"T519","obj":"T518"},{"id":"R75","pred":"nmod","subj":"T520","obj":"T515"},{"id":"R76","pred":"nmod","subj":"T521","obj":"T520"},{"id":"R77","pred":"punct","subj":"T522","obj":"T520"},{"id":"R78","pred":"appos","subj":"T523","obj":"T520"},{"id":"R79","pred":"punct","subj":"T524","obj":"T515"},{"id":"R80","pred":"punct","subj":"T525","obj":"T506"},{"id":"R81","pred":"poss","subj":"T527","obj":"T528"},{"id":"R82","pred":"nsubj","subj":"T528","obj":"T529"},{"id":"R83","pred":"amod","subj":"T530","obj":"T531"},{"id":"R84","pred":"dobj","subj":"T531","obj":"T529"},{"id":"R85","pred":"prep","subj":"T532","obj":"T531"},{"id":"R86","pred":"compound","subj":"T533","obj":"T534"},{"id":"R87","pred":"pobj","subj":"T534","obj":"T532"},{"id":"R88","pred":"aux","subj":"T535","obj":"T536"},{"id":"R89","pred":"xcomp","subj":"T536","obj":"T529"},{"id":"R90","pred":"det","subj":"T537","obj":"T538"},{"id":"R91","pred":"dobj","subj":"T538","obj":"T536"},{"id":"R92","pred":"prep","subj":"T539","obj":"T538"},{"id":"R93","pred":"amod","subj":"T540","obj":"T541"},{"id":"R94","pred":"pobj","subj":"T541","obj":"T539"},{"id":"R95","pred":"punct","subj":"T542","obj":"T529"},{"id":"R96","pred":"cc","subj":"T544","obj":"T545"},{"id":"R97","pred":"advmod","subj":"T546","obj":"T547"},{"id":"R98","pred":"advmod","subj":"T547","obj":"T545"},{"id":"R99","pred":"punct","subj":"T548","obj":"T545"},{"id":"R100","pred":"det","subj":"T549","obj":"T550"},{"id":"R101","pred":"nsubjpass","subj":"T550","obj":"T545"},{"id":"R102","pred":"auxpass","subj":"T551","obj":"T545"},{"id":"R103","pred":"prep","subj":"T552","obj":"T545"},{"id":"R104","pred":"pobj","subj":"T553","obj":"T552"},{"id":"R105","pred":"prep","subj":"T554","obj":"T545"},{"id":"R106","pred":"amod","subj":"T555","obj":"T556"},{"id":"R107","pred":"pobj","subj":"T556","obj":"T554"},{"id":"R108","pred":"aux","subj":"T557","obj":"T558"},{"id":"R109","pred":"advcl","subj":"T558","obj":"T545"},{"id":"R110","pred":"dobj","subj":"T559","obj":"T558"},{"id":"R111","pred":"punct","subj":"T560","obj":"T559"},{"id":"R112","pred":"compound","subj":"T561","obj":"T562"},{"id":"R113","pred":"appos","subj":"T562","obj":"T559"},{"id":"R114","pred":"punct","subj":"T563","obj":"T562"},{"id":"R115","pred":"punct","subj":"T564","obj":"T545"},{"id":"R116","pred":"punct","subj":"T565","obj":"T545"},{"id":"R117","pred":"nsubj","subj":"T567","obj":"T568"},{"id":"R118","pred":"dobj","subj":"T569","obj":"T568"},{"id":"R119","pred":"punct","subj":"T570","obj":"T569"},{"id":"R120","pred":"prep","subj":"T571","obj":"T569"},{"id":"R121","pred":"punct","subj":"T572","obj":"T571"},{"id":"R122","pred":"pobj","subj":"T573","obj":"T571"},{"id":"R123","pred":"prep","subj":"T574","obj":"T568"},{"id":"R124","pred":"pobj","subj":"T575","obj":"T574"},{"id":"R125","pred":"prep","subj":"T576","obj":"T568"},{"id":"R126","pred":"det","subj":"T577","obj":"T578"},{"id":"R127","pred":"pobj","subj":"T578","obj":"T576"},{"id":"R128","pred":"compound","subj":"T579","obj":"T578"},{"id":"R129","pred":"punct","subj":"T580","obj":"T568"},{"id":"R130","pred":"prep","subj":"T581","obj":"T568"},{"id":"R131","pred":"pcomp","subj":"T582","obj":"T581"}],"text":"locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Our approach enables efficient targeting in ES cells to facilitate the production of mutant mice. But more importantly, the approach was Adapted for targeting in Somatic cells to Accelerate Phenotyping (RMCE-ASAP). We provide proof-of-concept for this at the p53 locus, by showing effic"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T419","span":{"begin":32,"end":43},"obj":"GO_EXT:recombinase"},{"id":"T420","span":{"begin":53,"end":61},"obj":"SO_EXT:0005853"},{"id":"T421","span":{"begin":62,"end":70},"obj":"SO_EXT:sequence_substitution_process"},{"id":"T422","span":{"begin":130,"end":138},"obj":"CL:0002322"},{"id":"T423","span":{"begin":133,"end":138},"obj":"CL_GO_EXT:cell"},{"id":"T424","span":{"begin":171,"end":177},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T425","span":{"begin":178,"end":182},"obj":"NCBITaxon:10088"},{"id":"T426","span":{"begin":248,"end":261},"obj":"CL:0002371"},{"id":"T427","span":{"begin":256,"end":261},"obj":"CL_GO_EXT:cell"},{"id":"T428","span":{"begin":345,"end":348},"obj":"PR_EXT:000003035"}],"text":"locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Our approach enables efficient targeting in ES cells to facilitate the production of mutant mice. But more importantly, the approach was Adapted for targeting in Somatic cells to Accelerate Phenotyping (RMCE-ASAP). We provide proof-of-concept for this at the p53 locus, by showing effic"}

{"project":"craft-ca-core-dev","denotations":[{"id":"T394","span":{"begin":53,"end":61},"obj":"SO:0005853"},{"id":"T395","span":{"begin":130,"end":138},"obj":"CL:0002322"},{"id":"T396","span":{"begin":178,"end":182},"obj":"NCBITaxon:10088"},{"id":"T397","span":{"begin":248,"end":261},"obj":"CL:0002371"},{"id":"T398","span":{"begin":345,"end":348},"obj":"PR:000003035"}],"text":"locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Our approach enables efficient targeting in ES cells to facilitate the production of mutant mice. But more importantly, the approach was Adapted for targeting in Somatic cells to Accelerate Phenotyping (RMCE-ASAP). We provide proof-of-concept for this at the p53 locus, by showing effic"}