PMC:1540739 / 3087-3223 JSONTXT

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{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2473","span":{"begin":43,"end":52},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T2474","span":{"begin":80,"end":89},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T2475","span":{"begin":117,"end":127},"obj":"GO:0010467"},{"id":"T2476","span":{"begin":128,"end":135},"obj":"SO_EXT:0001023"}],"text":" However, modeling most disease-associated mutations requires generating subtle mutations, not knock-outs or reduced expression alleles."}

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