PMC:1540739 / 223-614 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1540739","sourcedb":"PMC","sourceid":"1540739","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1540739","text":"logous recombination in ES cells to generate mutant mice. Although informative, this approach is inefficient, slow and expensive. To facilitate targeting at the p53 locus, we developed an improved Recombinase-Mediated Cassette Exchange (RMCE) method. Our approach enables efficient targeting in ES cells to facilitate the production of mutant mice. But more importantly, the approach was Ada","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T481","span":{"begin":7,"end":20},"obj":"NN"},{"id":"T482","span":{"begin":21,"end":23},"obj":"IN"},{"id":"T483","span":{"begin":24,"end":26},"obj":"NN"},{"id":"T484","span":{"begin":27,"end":32},"obj":"NNS"},{"id":"T485","span":{"begin":33,"end":35},"obj":"TO"},{"id":"T486","span":{"begin":36,"end":44},"obj":"VB"},{"id":"T487","span":{"begin":45,"end":51},"obj":"JJ"},{"id":"T488","span":{"begin":52,"end":56},"obj":"NNS"},{"id":"T489","span":{"begin":56,"end":57},"obj":"."},{"id":"T490","span":{"begin":57,"end":129},"obj":"sentence"},{"id":"T491","span":{"begin":58,"end":66},"obj":"IN"},{"id":"T492","span":{"begin":67,"end":78},"obj":"JJ"},{"id":"T493","span":{"begin":94,"end":96},"obj":"VBZ"},{"id":"T494","span":{"begin":78,"end":80},"obj":","},{"id":"T495","span":{"begin":80,"end":84},"obj":"DT"},{"id":"T496","span":{"begin":85,"end":93},"obj":"NN"},{"id":"T497","span":{"begin":97,"end":108},"obj":"JJ"},{"id":"T498","span":{"begin":108,"end":110},"obj":","},{"id":"T499","span":{"begin":110,"end":114},"obj":"JJ"},{"id":"T500","span":{"begin":115,"end":118},"obj":"CC"},{"id":"T501","span":{"begin":119,"end":128},"obj":"JJ"},{"id":"T502","span":{"begin":128,"end":129},"obj":"."},{"id":"T503","span":{"begin":129,"end":250},"obj":"sentence"},{"id":"T504","span":{"begin":130,"end":132},"obj":"TO"},{"id":"T505","span":{"begin":133,"end":143},"obj":"VB"},{"id":"T506","span":{"begin":175,"end":184},"obj":"VBD"},{"id":"T507","span":{"begin":144,"end":153},"obj":"NN"},{"id":"T508","span":{"begin":154,"end":156},"obj":"IN"},{"id":"T509","span":{"begin":157,"end":160},"obj":"DT"},{"id":"T510","span":{"begin":165,"end":170},"obj":"NN"},{"id":"T511","span":{"begin":161,"end":164},"obj":"NN"},{"id":"T512","span":{"begin":170,"end":172},"obj":","},{"id":"T513","span":{"begin":172,"end":174},"obj":"PRP"},{"id":"T514","span":{"begin":185,"end":187},"obj":"DT"},{"id":"T515","span":{"begin":243,"end":249},"obj":"NN"},{"id":"T516","span":{"begin":188,"end":196},"obj":"VBN"},{"id":"T517","span":{"begin":197,"end":208},"obj":"NN"},{"id":"T518","span":{"begin":209,"end":217},"obj":"JJ"},{"id":"T519","span":{"begin":208,"end":209},"obj":"HYPH"},{"id":"T520","span":{"begin":227,"end":235},"obj":"NNP"},{"id":"T521","span":{"begin":218,"end":226},"obj":"NNP"},{"id":"T522","span":{"begin":236,"end":237},"obj":"-LRB-"},{"id":"T523","span":{"begin":237,"end":241},"obj":"NN"},{"id":"T524","span":{"begin":241,"end":242},"obj":"-RRB-"},{"id":"T525","span":{"begin":249,"end":250},"obj":"."},{"id":"T526","span":{"begin":250,"end":348},"obj":"sentence"},{"id":"T527","span":{"begin":251,"end":254},"obj":"PRP$"},{"id":"T528","span":{"begin":255,"end":263},"obj":"NN"},{"id":"T529","span":{"begin":264,"end":271},"obj":"VBZ"},{"id":"T530","span":{"begin":272,"end":281},"obj":"JJ"},{"id":"T531","span":{"begin":282,"end":291},"obj":"NN"},{"id":"T532","span":{"begin":292,"end":294},"obj":"IN"},{"id":"T533","span":{"begin":295,"end":297},"obj":"NN"},{"id":"T534","span":{"begin":298,"end":303},"obj":"NNS"},{"id":"T535","span":{"begin":304,"end":306},"obj":"TO"},{"id":"T536","span":{"begin":307,"end":317},"obj":"VB"},{"id":"T537","span":{"begin":318,"end":321},"obj":"DT"},{"id":"T538","span":{"begin":322,"end":332},"obj":"NN"},{"id":"T539","span":{"begin":333,"end":335},"obj":"IN"},{"id":"T540","span":{"begin":336,"end":342},"obj":"JJ"},{"id":"T541","span":{"begin":343,"end":347},"obj":"NNS"},{"id":"T542","span":{"begin":347,"end":348},"obj":"."},{"id":"T544","span":{"begin":349,"end":352},"obj":"CC"},{"id":"T546","span":{"begin":353,"end":357},"obj":"RBR"},{"id":"T547","span":{"begin":358,"end":369},"obj":"RB"},{"id":"T548","span":{"begin":369,"end":371},"obj":","},{"id":"T549","span":{"begin":371,"end":374},"obj":"DT"},{"id":"T550","span":{"begin":375,"end":383},"obj":"NN"},{"id":"T551","span":{"begin":384,"end":387},"obj":"VBD"}],"relations":[{"id":"R42","pred":"compound","subj":"T483","obj":"T484"},{"id":"R43","pred":"pobj","subj":"T484","obj":"T482"},{"id":"R44","pred":"aux","subj":"T485","obj":"T486"},{"id":"R46","pred":"amod","subj":"T487","obj":"T488"},{"id":"R47","pred":"dobj","subj":"T488","obj":"T486"},{"id":"R49","pred":"mark","subj":"T491","obj":"T492"},{"id":"R50","pred":"advcl","subj":"T492","obj":"T493"},{"id":"R51","pred":"punct","subj":"T494","obj":"T493"},{"id":"R52","pred":"det","subj":"T495","obj":"T496"},{"id":"R53","pred":"nsubj","subj":"T496","obj":"T493"},{"id":"R54","pred":"acomp","subj":"T497","obj":"T493"},{"id":"R55","pred":"punct","subj":"T498","obj":"T497"},{"id":"R56","pred":"conj","subj":"T499","obj":"T497"},{"id":"R57","pred":"cc","subj":"T500","obj":"T499"},{"id":"R58","pred":"conj","subj":"T501","obj":"T499"},{"id":"R59","pred":"punct","subj":"T502","obj":"T493"},{"id":"R60","pred":"aux","subj":"T504","obj":"T505"},{"id":"R61","pred":"advcl","subj":"T505","obj":"T506"},{"id":"R62","pred":"dobj","subj":"T507","obj":"T505"},{"id":"R63","pred":"prep","subj":"T508","obj":"T505"},{"id":"R64","pred":"det","subj":"T509","obj":"T510"},{"id":"R65","pred":"pobj","subj":"T510","obj":"T508"},{"id":"R66","pred":"compound","subj":"T511","obj":"T510"},{"id":"R67","pred":"punct","subj":"T512","obj":"T506"},{"id":"R68","pred":"nsubj","subj":"T513","obj":"T506"},{"id":"R69","pred":"det","subj":"T514","obj":"T515"},{"id":"R70","pred":"dobj","subj":"T515","obj":"T506"},{"id":"R71","pred":"amod","subj":"T516","obj":"T515"},{"id":"R72","pred":"npadvmod","subj":"T517","obj":"T518"},{"id":"R73","pred":"amod","subj":"T518","obj":"T520"},{"id":"R74","pred":"punct","subj":"T519","obj":"T518"},{"id":"R75","pred":"nmod","subj":"T520","obj":"T515"},{"id":"R76","pred":"nmod","subj":"T521","obj":"T520"},{"id":"R77","pred":"punct","subj":"T522","obj":"T520"},{"id":"R78","pred":"appos","subj":"T523","obj":"T520"},{"id":"R79","pred":"punct","subj":"T524","obj":"T515"},{"id":"R80","pred":"punct","subj":"T525","obj":"T506"},{"id":"R81","pred":"poss","subj":"T527","obj":"T528"},{"id":"R82","pred":"nsubj","subj":"T528","obj":"T529"},{"id":"R83","pred":"amod","subj":"T530","obj":"T531"},{"id":"R84","pred":"dobj","subj":"T531","obj":"T529"},{"id":"R85","pred":"prep","subj":"T532","obj":"T531"},{"id":"R86","pred":"compound","subj":"T533","obj":"T534"},{"id":"R87","pred":"pobj","subj":"T534","obj":"T532"},{"id":"R88","pred":"aux","subj":"T535","obj":"T536"},{"id":"R89","pred":"xcomp","subj":"T536","obj":"T529"},{"id":"R90","pred":"det","subj":"T537","obj":"T538"},{"id":"R91","pred":"dobj","subj":"T538","obj":"T536"},{"id":"R92","pred":"prep","subj":"T539","obj":"T538"},{"id":"R93","pred":"amod","subj":"T540","obj":"T541"},{"id":"R94","pred":"pobj","subj":"T541","obj":"T539"},{"id":"R95","pred":"punct","subj":"T542","obj":"T529"},{"id":"R97","pred":"advmod","subj":"T546","obj":"T547"},{"id":"R100","pred":"det","subj":"T549","obj":"T550"}],"attributes":[{"subj":"T481","pred":"source","obj":"craft-sa-dev"},{"subj":"T482","pred":"source","obj":"craft-sa-dev"},{"subj":"T483","pred":"source","obj":"craft-sa-dev"},{"subj":"T484","pred":"source","obj":"craft-sa-dev"},{"subj":"T485","pred":"source","obj":"craft-sa-dev"},{"subj":"T486","pred":"source","obj":"craft-sa-dev"},{"subj":"T487","pred":"source","obj":"craft-sa-dev"},{"subj":"T488","pred":"source","obj":"craft-sa-dev"},{"subj":"T489","pred":"source","obj":"craft-sa-dev"},{"subj":"T490","pred":"source","obj":"craft-sa-dev"},{"subj":"T491","pred":"source","obj":"craft-sa-dev"},{"subj":"T492","pred":"source","obj":"craft-sa-dev"},{"subj":"T493","pred":"source","obj":"craft-sa-dev"},{"subj":"T494","pred":"source","obj":"craft-sa-dev"},{"subj":"T495","pred":"source","obj":"craft-sa-dev"},{"subj":"T496","pred":"source","obj":"craft-sa-dev"},{"subj":"T497","pred":"source","obj":"craft-sa-dev"},{"subj":"T498","pred":"source","obj":"craft-sa-dev"},{"subj":"T499","pred":"source","obj":"craft-sa-dev"},{"subj":"T500","pred":"source","obj":"craft-sa-dev"},{"subj":"T501","pred":"source","obj":"craft-sa-dev"},{"subj":"T502","pred":"source","obj":"craft-sa-dev"},{"subj":"T503","pred":"source","obj":"craft-sa-dev"},{"subj":"T504","pred":"source","obj":"craft-sa-dev"},{"subj":"T505","pred":"source","obj":"craft-sa-dev"},{"subj":"T506","pred":"source","obj":"craft-sa-dev"},{"subj":"T507","pred":"source","obj":"craft-sa-dev"},{"subj":"T508","pred":"source","obj":"craft-sa-dev"},{"subj":"T509","pred":"source","obj":"craft-sa-dev"},{"subj":"T510","pred":"source","obj":"craft-sa-dev"},{"subj":"T511","pred":"source","obj":"craft-sa-dev"},{"subj":"T512","pred":"source","obj":"craft-sa-dev"},{"subj":"T513","pred":"source","obj":"craft-sa-dev"},{"subj":"T514","pred":"source","obj":"craft-sa-dev"},{"subj":"T515","pred":"source","obj":"craft-sa-dev"},{"subj":"T516","pred":"source","obj":"craft-sa-dev"},{"subj":"T517","pred":"source","obj":"craft-sa-dev"},{"subj":"T518","pred":"source","obj":"craft-sa-dev"},{"subj":"T519","pred":"source","obj":"craft-sa-dev"},{"subj":"T520","pred":"source","obj":"craft-sa-dev"},{"subj":"T521","pred":"source","obj":"craft-sa-dev"},{"subj":"T522","pred":"source","obj":"craft-sa-dev"},{"subj":"T523","pred":"source","obj":"craft-sa-dev"},{"subj":"T524","pred":"source","obj":"craft-sa-dev"},{"subj":"T525","pred":"source","obj":"craft-sa-dev"},{"subj":"T526","pred":"source","obj":"craft-sa-dev"},{"subj":"T527","pred":"source","obj":"craft-sa-dev"},{"subj":"T528","pred":"source","obj":"craft-sa-dev"},{"subj":"T529","pred":"source","obj":"craft-sa-dev"},{"subj":"T530","pred":"source","obj":"craft-sa-dev"},{"subj":"T531","pred":"source","obj":"craft-sa-dev"},{"subj":"T532","pred":"source","obj":"craft-sa-dev"},{"subj":"T533","pred":"source","obj":"craft-sa-dev"},{"subj":"T534","pred":"source","obj":"craft-sa-dev"},{"subj":"T535","pred":"source","obj":"craft-sa-dev"},{"subj":"T536","pred":"source","obj":"craft-sa-dev"},{"subj":"T537","pred":"source","obj":"craft-sa-dev"},{"subj":"T538","pred":"source","obj":"craft-sa-dev"},{"subj":"T539","pred":"source","obj":"craft-sa-dev"},{"subj":"T540","pred":"source","obj":"craft-sa-dev"},{"subj":"T541","pred":"source","obj":"craft-sa-dev"},{"subj":"T542","pred":"source","obj":"craft-sa-dev"},{"subj":"T544","pred":"source","obj":"craft-sa-dev"},{"subj":"T546","pred":"source","obj":"craft-sa-dev"},{"subj":"T547","pred":"source","obj":"craft-sa-dev"},{"subj":"T548","pred":"source","obj":"craft-sa-dev"},{"subj":"T549","pred":"source","obj":"craft-sa-dev"},{"subj":"T550","pred":"source","obj":"craft-sa-dev"},{"subj":"T551","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T413","span":{"begin":7,"end":20},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T414","span":{"begin":24,"end":32},"obj":"CL:0002322"},{"id":"T415","span":{"begin":27,"end":32},"obj":"CL_GO_EXT:cell"},{"id":"T416","span":{"begin":45,"end":51},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T417","span":{"begin":52,"end":56},"obj":"NCBITaxon:10088"},{"id":"T418","span":{"begin":161,"end":164},"obj":"PR_EXT:000003035"},{"id":"T419","span":{"begin":197,"end":208},"obj":"GO_EXT:recombinase"},{"id":"T420","span":{"begin":218,"end":226},"obj":"SO_EXT:0005853"},{"id":"T421","span":{"begin":227,"end":235},"obj":"SO_EXT:sequence_substitution_process"},{"id":"T422","span":{"begin":295,"end":303},"obj":"CL:0002322"},{"id":"T423","span":{"begin":298,"end":303},"obj":"CL_GO_EXT:cell"},{"id":"T424","span":{"begin":336,"end":342},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T425","span":{"begin":343,"end":347},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T413","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T414","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T415","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T416","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T417","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T418","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T419","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T420","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T421","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T422","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T423","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T424","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T425","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T391","span":{"begin":24,"end":32},"obj":"CL:0002322"},{"id":"T392","span":{"begin":52,"end":56},"obj":"NCBITaxon:10088"},{"id":"T393","span":{"begin":161,"end":164},"obj":"PR:000003035"},{"id":"T394","span":{"begin":218,"end":226},"obj":"SO:0005853"},{"id":"T395","span":{"begin":295,"end":303},"obj":"CL:0002322"},{"id":"T396","span":{"begin":343,"end":347},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T391","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T392","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T393","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T394","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T395","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T396","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#93a3ec","default":true},{"id":"craft-ca-core-ex-dev","color":"#bdec93"},{"id":"craft-ca-core-dev","color":"#ec93d7"}]}]}}