PMC:1540739 / 16527-17736
Annnotations
craft-sa-dev
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12164 | 0-2 | TO | denotes | To |
T12165 | 3-7 | VB | denotes | test |
T12166 | 29-38 | VBD | denotes | performed |
T12167 | 8-12 | DT | denotes | this |
T12168 | 13-24 | NN | denotes | possibility |
T12169 | 24-26 | , | denotes | , |
T12170 | 26-28 | PRP | denotes | we |
T12171 | 39-43 | NN | denotes | RMCE |
T12172 | 44-48 | IN | denotes | with |
T12173 | 49-50 | DT | denotes | a |
T12174 | 62-66 | NN | denotes | gene |
T12175 | 51-54 | NN | denotes | p53 |
T12176 | 55-61 | NN | denotes | fusion |
T12177 | 67-69 | IN | denotes | in |
T12178 | 114-121 | VBN | denotes | deleted |
T12179 | 70-75 | WDT | denotes | which |
T12180 | 76-79 | DT | denotes | the |
T12181 | 97-103 | NN | denotes | domain |
T12182 | 80-83 | NN | denotes | p53 |
T12183 | 84-91 | NN | denotes | proline |
T12184 | 92-96 | JJ | denotes | rich |
T12185 | 91-92 | HYPH | denotes | - |
T12186 | 104-105 | -LRB- | denotes | ( |
T12187 | 105-108 | NN | denotes | PRD |
T12188 | 108-109 | -RRB- | denotes | ) |
T12189 | 110-113 | VBD | denotes | was |
T12190 | 122-123 | -LRB- | denotes | ( |
T12191 | 123-128 | NN | denotes | p53ΔP |
T12192 | 128-129 | -RRB- | denotes | ) |
T12193 | 129-131 | , | denotes | , |
T12194 | 131-134 | CC | denotes | and |
T12195 | 135-138 | DT | denotes | the |
T12196 | 139-144 | NN | denotes | p53ΔP |
T12197 | 149-154 | VBN | denotes | fused |
T12198 | 145-148 | VBD | denotes | was |
T12199 | 155-157 | IN | denotes | to |
T12200 | 158-161 | NN | denotes | GFP |
T12201 | 161-162 | . | denotes | . |
T12202 | 162-293 | sentence | denotes | We used this mutant because deleting the proline-rich domain decreases stability and compromises DNA-damage responses in vivo (5). |
T12203 | 163-165 | PRP | denotes | We |
T12204 | 166-170 | VBD | denotes | used |
T12205 | 171-175 | DT | denotes | this |
T12206 | 176-182 | NN | denotes | mutant |
T12207 | 183-190 | IN | denotes | because |
T12208 | 224-233 | VBZ | denotes | decreases |
T12209 | 191-199 | VBG | denotes | deleting |
T12210 | 200-203 | DT | denotes | the |
T12211 | 217-223 | NN | denotes | domain |
T12212 | 204-211 | NN | denotes | proline |
T12213 | 212-216 | JJ | denotes | rich |
T12214 | 211-212 | HYPH | denotes | - |
T12215 | 234-243 | NN | denotes | stability |
T12216 | 244-247 | CC | denotes | and |
T12217 | 248-259 | VBZ | denotes | compromises |
T12218 | 260-263 | NN | denotes | DNA |
T12219 | 264-270 | NN | denotes | damage |
T12220 | 263-264 | HYPH | denotes | - |
T12221 | 271-280 | NNS | denotes | responses |
T12222 | 281-283 | FW | denotes | in |
T12223 | 284-288 | FW | denotes | vivo |
T12224 | 289-290 | -LRB- | denotes | ( |
T12225 | 290-291 | CD | denotes | 5 |
T12226 | 291-292 | -RRB- | denotes | ) |
T12227 | 292-293 | . | denotes | . |
T12228 | 293-388 | sentence | denotes | According to our hypothesis, this hypomorphic mutant should not prevent embryonic development. |
T12229 | 294-303 | VBG | denotes | According |
T12230 | 358-365 | VB | denotes | prevent |
T12231 | 304-306 | IN | denotes | to |
T12232 | 307-310 | PRP$ | denotes | our |
T12233 | 311-321 | NN | denotes | hypothesis |
T12234 | 321-323 | , | denotes | , |
T12235 | 323-327 | DT | denotes | this |
T12236 | 340-346 | NN | denotes | mutant |
T12237 | 328-339 | JJ | denotes | hypomorphic |
T12238 | 347-353 | MD | denotes | should |
T12239 | 354-357 | RB | denotes | not |
T12240 | 366-375 | JJ | denotes | embryonic |
T12241 | 376-387 | NN | denotes | development |
T12242 | 387-388 | . | denotes | . |
T12243 | 388-575 | sentence | denotes | RMCE with a p53ΔPGFP replacement plasmid was again very efficient and western blots revealed an additional band of the predicted molecular weight only in p53+/ΔPGFP ES cells (Figure 3B). |
T12244 | 389-393 | NN | denotes | RMCE |
T12245 | 430-433 | VBD | denotes | was |
T12246 | 394-398 | IN | denotes | with |
T12247 | 399-400 | DT | denotes | a |
T12248 | 422-429 | NN | denotes | plasmid |
T12249 | 401-409 | NN | denotes | p53ΔPGFP |
T12250 | 410-421 | NN | denotes | replacement |
T12251 | 434-439 | RB | denotes | again |
T12252 | 440-444 | RB | denotes | very |
T12253 | 445-454 | JJ | denotes | efficient |
T12254 | 455-458 | CC | denotes | and |
T12255 | 459-466 | NNP | denotes | western |
T12256 | 467-472 | NNS | denotes | blots |
T12257 | 473-481 | VBD | denotes | revealed |
T12258 | 482-484 | DT | denotes | an |
T12259 | 496-500 | NN | denotes | band |
T12260 | 485-495 | JJ | denotes | additional |
T12261 | 501-503 | IN | denotes | of |
T12262 | 504-507 | DT | denotes | the |
T12263 | 528-534 | NN | denotes | weight |
T12264 | 508-517 | VBN | denotes | predicted |
T12265 | 518-527 | JJ | denotes | molecular |
T12266 | 535-539 | RB | denotes | only |
T12267 | 540-542 | IN | denotes | in |
T12268 | 543-546 | NN | denotes | p53 |
T12269 | 548-553 | NN | denotes | ΔPGFP |
T12270 | 546-547 | SYM | denotes | + |
T12271 | 547-548 | HYPH | denotes | / |
T12272 | 557-562 | NNS | denotes | cells |
T12273 | 554-556 | NN | denotes | ES |
T12274 | 563-564 | -LRB- | denotes | ( |
T12275 | 571-573 | NN | denotes | 3B |
T12276 | 564-570 | NN | denotes | Figure |
T12277 | 573-574 | -RRB- | denotes | ) |
T12278 | 574-575 | . | denotes | . |
T12279 | 575-727 | sentence | denotes | As expected, the PRD deletion correlated with lower expression levels: p53ΔPGFP was much less abundant than p53WT in all p53+/ΔPGFP clones (Figure 3B). |
T12280 | 576-578 | IN | denotes | As |
T12281 | 579-587 | VBN | denotes | expected |
T12282 | 606-616 | VBD | denotes | correlated |
T12283 | 587-589 | , | denotes | , |
T12284 | 589-592 | DT | denotes | the |
T12285 | 597-605 | NN | denotes | deletion |
T12286 | 593-596 | NN | denotes | PRD |
T12287 | 656-659 | VBD | denotes | was |
T12288 | 617-621 | IN | denotes | with |
T12289 | 622-627 | JJR | denotes | lower |
T12290 | 639-645 | NNS | denotes | levels |
T12291 | 628-638 | NN | denotes | expression |
T12292 | 645-647 | : | denotes | : |
T12293 | 647-655 | NN | denotes | p53ΔPGFP |
T12294 | 660-664 | RB | denotes | much |
T12295 | 665-669 | RBR | denotes | less |
T12296 | 670-678 | JJ | denotes | abundant |
T12297 | 679-683 | IN | denotes | than |
T12298 | 684-689 | NN | denotes | p53WT |
T12299 | 690-692 | IN | denotes | in |
T12300 | 693-696 | DT | denotes | all |
T12301 | 708-714 | NNS | denotes | clones |
T12302 | 697-700 | NN | denotes | p53 |
T12303 | 702-707 | NN | denotes | ΔPGFP |
T12304 | 700-701 | SYM | denotes | + |
T12305 | 701-702 | HYPH | denotes | / |
T12306 | 715-716 | -LRB- | denotes | ( |
T12307 | 723-725 | NN | denotes | 3B |
T12308 | 716-722 | NN | denotes | Figure |
T12309 | 725-726 | -RRB- | denotes | ) |
T12310 | 726-727 | . | denotes | . |
T12311 | 727-858 | sentence | denotes | We next determined whether p53+/ΔPGFP ES cells could generate chimeric mice and transmit the modified allele through the germline. |
T12312 | 728-730 | PRP | denotes | We |
T12313 | 736-746 | VBD | denotes | determined |
T12314 | 731-735 | RB | denotes | next |
T12315 | 747-754 | IN | denotes | whether |
T12316 | 781-789 | VB | denotes | generate |
T12317 | 755-758 | NN | denotes | p53 |
T12318 | 760-765 | NN | denotes | ΔPGFP |
T12319 | 758-759 | SYM | denotes | + |
T12320 | 759-760 | HYPH | denotes | / |
T12321 | 769-774 | NNS | denotes | cells |
T12322 | 766-768 | NN | denotes | ES |
T12323 | 775-780 | MD | denotes | could |
T12324 | 790-798 | JJ | denotes | chimeric |
T12325 | 799-803 | NNS | denotes | mice |
T12326 | 804-807 | CC | denotes | and |
T12327 | 808-816 | VB | denotes | transmit |
T12328 | 817-820 | DT | denotes | the |
T12329 | 830-836 | NN | denotes | allele |
T12330 | 821-829 | VBN | denotes | modified |
T12331 | 837-844 | IN | denotes | through |
T12332 | 845-848 | DT | denotes | the |
T12333 | 849-857 | NN | denotes | germline |
T12334 | 857-858 | . | denotes | . |
T12335 | 858-966 | sentence | denotes | Two p53+/ΔPGFP ES cell clones were injected into blastocysts and highly chimeric (>80%) mice were obtained. |
T12336 | 859-862 | CD | denotes | Two |
T12337 | 882-888 | NNS | denotes | clones |
T12338 | 863-866 | NN | denotes | p53 |
T12339 | 868-873 | NN | denotes | ΔPGFP |
T12340 | 866-867 | SYM | denotes | + |
T12341 | 867-868 | HYPH | denotes | / |
T12342 | 874-876 | NN | denotes | ES |
T12343 | 877-881 | NN | denotes | cell |
T12344 | 894-902 | VBN | denotes | injected |
T12345 | 889-893 | VBD | denotes | were |
T12346 | 903-907 | IN | denotes | into |
T12347 | 908-919 | NNS | denotes | blastocysts |
T12348 | 920-923 | CC | denotes | and |
T12349 | 924-930 | RB | denotes | highly |
T12350 | 931-939 | JJ | denotes | chimeric |
T12351 | 944-945 | NN | denotes | % |
T12352 | 940-941 | -LRB- | denotes | ( |
T12353 | 941-942 | SYM | denotes | > |
T12354 | 942-944 | CD | denotes | 80 |
T12355 | 947-951 | NNS | denotes | mice |
T12356 | 945-946 | -RRB- | denotes | ) |
T12357 | 957-965 | VBN | denotes | obtained |
T12358 | 952-956 | VBD | denotes | were |
T12359 | 965-966 | . | denotes | . |
T12360 | 966-1054 | sentence | denotes | Heterozygote pups were recovered from the mating the chimeras with WT mice (Figure 3C). |
T12361 | 967-979 | NN | denotes | Heterozygote |
T12362 | 980-984 | NNS | denotes | pups |
T12363 | 990-999 | VBN | denotes | recovered |
T12364 | 985-989 | VBD | denotes | were |
T12365 | 1000-1004 | IN | denotes | from |
T12366 | 1005-1008 | DT | denotes | the |
T12367 | 1009-1015 | NN | denotes | mating |
T12368 | 1016-1019 | DT | denotes | the |
T12369 | 1020-1028 | NNS | denotes | chimeras |
T12370 | 1029-1033 | IN | denotes | with |
T12371 | 1034-1036 | NN | denotes | WT |
T12372 | 1037-1041 | NNS | denotes | mice |
T12373 | 1042-1043 | -LRB- | denotes | ( |
T12374 | 1050-1052 | NN | denotes | 3C |
T12375 | 1043-1049 | NN | denotes | Figure |
T12376 | 1052-1053 | -RRB- | denotes | ) |
T12377 | 1053-1054 | . | denotes | . |
T12378 | 1054-1209 | sentence | denotes | These data demonstrate that marker-free RMCE is very efficient in ES cells and allows germline transmission of a targeted mutation (see Figure 1, path A). |
T12379 | 1055-1060 | DT | denotes | These |
T12380 | 1061-1065 | NNS | denotes | data |
T12381 | 1066-1077 | VBP | denotes | demonstrate |
T12382 | 1078-1082 | IN | denotes | that |
T12383 | 1100-1102 | VBZ | denotes | is |
T12384 | 1083-1089 | NN | denotes | marker |
T12385 | 1090-1094 | JJ | denotes | free |
T12386 | 1089-1090 | HYPH | denotes | - |
T12387 | 1095-1099 | NN | denotes | RMCE |
T12388 | 1103-1107 | RB | denotes | very |
T12389 | 1108-1117 | JJ | denotes | efficient |
T12390 | 1118-1120 | IN | denotes | in |
T12391 | 1121-1123 | NN | denotes | ES |
T12392 | 1124-1129 | NNS | denotes | cells |
T12393 | 1130-1133 | CC | denotes | and |
T12394 | 1134-1140 | VBZ | denotes | allows |
T12395 | 1141-1149 | NN | denotes | germline |
T12396 | 1150-1162 | NN | denotes | transmission |
T12397 | 1163-1165 | IN | denotes | of |
T12398 | 1166-1167 | DT | denotes | a |
T12399 | 1177-1185 | NN | denotes | mutation |
T12400 | 1168-1176 | VBN | denotes | targeted |
T12401 | 1186-1187 | -LRB- | denotes | ( |
T12402 | 1187-1190 | VB | denotes | see |
T12403 | 1191-1197 | NN | denotes | Figure |
T12404 | 1198-1199 | CD | denotes | 1 |
T12405 | 1199-1201 | , | denotes | , |
T12406 | 1201-1205 | NN | denotes | path |
T12407 | 1206-1207 | NN | denotes | A |
T12408 | 1207-1208 | -RRB- | denotes | ) |
T12409 | 1208-1209 | . | denotes | . |
R3050 | T12167 | T12168 | det | this,possibility |
R3056 | T12168 | T12165 | dobj | possibility,test |
R3060 | T12169 | T12166 | punct | ", ",performed |
R3064 | T12170 | T12166 | nsubj | we,performed |
R3067 | T12171 | T12166 | dobj | RMCE,performed |
R3071 | T12172 | T12166 | prep | with,performed |
R3076 | T12173 | T12174 | det | a,gene |
R3078 | T12174 | T12172 | pobj | gene,with |
R3080 | T12175 | T12176 | compound | p53,fusion |
R3087 | T12176 | T12174 | compound | fusion,gene |
R3091 | T12177 | T12178 | prep | in,deleted |
R3095 | T12178 | T12174 | advcl | deleted,gene |
R3098 | T12179 | T12177 | pobj | which,in |
R3102 | T12180 | T12181 | det | the,domain |
R3104 | T12181 | T12178 | nsubjpass | domain,deleted |
R3108 | T12182 | T12181 | nmod | p53,domain |
R3112 | T12183 | T12184 | npadvmod | proline,rich |
R3116 | T12184 | T12181 | amod | rich,domain |
R3119 | T12185 | T12184 | punct | -,rich |
R3123 | T12186 | T12181 | punct | (,domain |
R3126 | T12187 | T12181 | appos | PRD,domain |
R3131 | T12188 | T12178 | punct | ),deleted |
R3137 | T12189 | T12178 | auxpass | was,deleted |
R3141 | T12190 | T12191 | punct | (,p53ΔP |
R3145 | T12191 | T12178 | parataxis | p53ΔP,deleted |
R3149 | T12192 | T12191 | punct | ),p53ΔP |
R3152 | T12193 | T12178 | punct | ", ",deleted |
R3156 | T12194 | T12178 | cc | and,deleted |
R3159 | T12195 | T12196 | det | the,p53ΔP |
R3160 | T12164 | T12165 | aux | To,test |
R3161 | T12165 | T12166 | advcl | test,performed |
R3162 | T12196 | T12197 | nsubjpass | p53ΔP,fused |
R3163 | T12197 | T12178 | conj | fused,deleted |
R3164 | T12198 | T12197 | auxpass | was,fused |
R3165 | T12273 | T12272 | compound | ES,cells |
R3166 | T12274 | T12275 | punct | (,3B |
R3167 | T12199 | T12197 | prep | to,fused |
R3168 | T12275 | T12257 | parataxis | 3B,revealed |
R3169 | T12276 | T12275 | compound | Figure,3B |
R3170 | T12277 | T12275 | punct | ),3B |
R3171 | T12200 | T12199 | pobj | GFP,to |
R3172 | T12278 | T12257 | punct | .,revealed |
R3173 | T12201 | T12166 | punct | .,performed |
R3174 | T12280 | T12281 | mark | As,expected |
R3175 | T12203 | T12204 | nsubj | We,used |
R3176 | T12281 | T12282 | advcl | expected,correlated |
R3177 | T12282 | T12287 | ccomp | correlated,was |
R3178 | T12283 | T12282 | punct | ", ",correlated |
R3179 | T12205 | T12206 | det | this,mutant |
R3180 | T12284 | T12285 | det | the,deletion |
R3181 | T12285 | T12282 | nsubj | deletion,correlated |
R3182 | T12286 | T12285 | compound | PRD,deletion |
R3183 | T12206 | T12204 | dobj | mutant,used |
R3184 | T12288 | T12282 | prep | with,correlated |
R3185 | T12289 | T12290 | amod | lower,levels |
R3186 | T12290 | T12288 | pobj | levels,with |
R3187 | T12291 | T12290 | compound | expression,levels |
R3188 | T12292 | T12287 | punct | : ,was |
R3189 | T12207 | T12208 | mark | because,decreases |
R3190 | T12293 | T12287 | nsubj | p53ΔPGFP,was |
R3191 | T12294 | T12295 | advmod | much,less |
R3192 | T12295 | T12296 | advmod | less,abundant |
R3193 | T12208 | T12204 | advcl | decreases,used |
R3194 | T12296 | T12287 | acomp | abundant,was |
R3195 | T12297 | T12296 | prep | than,abundant |
R3196 | T12298 | T12297 | pobj | p53WT,than |
R3197 | T12209 | T12208 | csubj | deleting,decreases |
R3198 | T12299 | T12298 | prep | in,p53WT |
R3199 | T12300 | T12301 | det | all,clones |
R3200 | T12301 | T12299 | pobj | clones,in |
R3201 | T12210 | T12211 | det | the,domain |
R3202 | T12302 | T12303 | nmod | p53,ΔPGFP |
R3203 | T12303 | T12301 | compound | ΔPGFP,clones |
R3204 | T12304 | T12303 | punct | +,ΔPGFP |
R3205 | T12211 | T12209 | dobj | domain,deleting |
R3206 | T12305 | T12303 | punct | /,ΔPGFP |
R3207 | T12306 | T12307 | punct | (,3B |
R3208 | T12307 | T12287 | parataxis | 3B,was |
R3209 | T12212 | T12213 | npadvmod | proline,rich |
R3210 | T12308 | T12307 | compound | Figure,3B |
R3211 | T12309 | T12307 | punct | ),3B |
R3212 | T12310 | T12287 | punct | .,was |
R3213 | T12213 | T12211 | amod | rich,domain |
R3214 | T12312 | T12313 | nsubj | We,determined |
R3215 | T12214 | T12213 | punct | -,rich |
R3216 | T12314 | T12313 | advmod | next,determined |
R3217 | T12315 | T12316 | mark | whether,generate |
R3218 | T12215 | T12208 | dobj | stability,decreases |
R3219 | T12316 | T12313 | ccomp | generate,determined |
R3220 | T12317 | T12318 | nmod | p53,ΔPGFP |
R3221 | T12216 | T12208 | cc | and,decreases |
R3222 | T12318 | T12321 | compound | ΔPGFP,cells |
R3223 | T12217 | T12208 | conj | compromises,decreases |
R3224 | T12319 | T12318 | punct | +,ΔPGFP |
R3225 | T12218 | T12219 | compound | DNA,damage |
R3226 | T12320 | T12318 | punct | /,ΔPGFP |
R3227 | T12321 | T12316 | nsubj | cells,generate |
R3228 | T12219 | T12221 | compound | damage,responses |
R3229 | T12322 | T12321 | compound | ES,cells |
R3230 | T12220 | T12219 | punct | -,damage |
R3231 | T12323 | T12316 | aux | could,generate |
R3232 | T12324 | T12325 | amod | chimeric,mice |
R3233 | T12325 | T12316 | dobj | mice,generate |
R3234 | T12326 | T12316 | cc | and,generate |
R3235 | T12221 | T12217 | dobj | responses,compromises |
R3236 | T12327 | T12316 | conj | transmit,generate |
R3237 | T12328 | T12329 | det | the,allele |
R3238 | T12329 | T12327 | dobj | allele,transmit |
R3239 | T12330 | T12329 | amod | modified,allele |
R3240 | T12331 | T12327 | prep | through,transmit |
R3241 | T12332 | T12333 | det | the,germline |
R3242 | T12222 | T12223 | advmod | in,vivo |
R3243 | T12333 | T12331 | pobj | germline,through |
R3244 | T12334 | T12313 | punct | .,determined |
R3245 | T12223 | T12217 | advmod | vivo,compromises |
R3246 | T12336 | T12337 | nummod | Two,clones |
R3247 | T12337 | T12344 | nsubjpass | clones,injected |
R3248 | T12338 | T12339 | nmod | p53,ΔPGFP |
R3249 | T12224 | T12225 | punct | (,5 |
R3250 | T12339 | T12337 | compound | ΔPGFP,clones |
R3251 | T12340 | T12339 | punct | +,ΔPGFP |
R3252 | T12341 | T12339 | punct | /,ΔPGFP |
R3253 | T12225 | T12217 | parataxis | 5,compromises |
R3254 | T12342 | T12343 | compound | ES,cell |
R3255 | T12343 | T12337 | compound | cell,clones |
R3256 | T12226 | T12225 | punct | ),5 |
R3257 | T12345 | T12344 | auxpass | were,injected |
R3258 | T12346 | T12344 | prep | into,injected |
R3259 | T12227 | T12204 | punct | .,used |
R3260 | T12347 | T12346 | pobj | blastocysts,into |
R3261 | T12348 | T12344 | cc | and,injected |
R3262 | T12349 | T12350 | advmod | highly,chimeric |
R3263 | T12229 | T12230 | prep | According,prevent |
R3264 | T12350 | T12351 | amod | chimeric,% |
R3265 | T12351 | T12355 | amod | %,mice |
R3266 | T12352 | T12351 | punct | (,% |
R3267 | T12353 | T12351 | punct | >,% |
R3268 | T12231 | T12229 | prep | to,According |
R3269 | T12354 | T12351 | nummod | 80,% |
R3270 | T12355 | T12357 | nsubjpass | mice,obtained |
R3271 | T12356 | T12351 | punct | ),% |
R3272 | T12357 | T12344 | conj | obtained,injected |
R3273 | T12232 | T12233 | poss | our,hypothesis |
R3274 | T12358 | T12357 | auxpass | were,obtained |
R3275 | T12359 | T12357 | punct | .,obtained |
R3276 | T12233 | T12231 | pobj | hypothesis,to |
R3277 | T12361 | T12362 | compound | Heterozygote,pups |
R3278 | T12362 | T12363 | nsubjpass | pups,recovered |
R3279 | T12234 | T12230 | punct | ", ",prevent |
R3280 | T12364 | T12363 | auxpass | were,recovered |
R3281 | T12365 | T12363 | prep | from,recovered |
R3282 | T12235 | T12236 | det | this,mutant |
R3283 | T12366 | T12367 | det | the,mating |
R3284 | T12367 | T12365 | pobj | mating,from |
R3285 | T12236 | T12230 | nsubj | mutant,prevent |
R3286 | T12237 | T12236 | amod | hypomorphic,mutant |
R3287 | T12368 | T12369 | det | the,chimeras |
R3288 | T12369 | T12367 | nmod | chimeras,mating |
R3289 | T12370 | T12367 | prep | with,mating |
R3290 | T12371 | T12372 | compound | WT,mice |
R3291 | T12372 | T12370 | pobj | mice,with |
R3292 | T12373 | T12374 | punct | (,3C |
R3293 | T12374 | T12363 | parataxis | 3C,recovered |
R3294 | T12238 | T12230 | aux | should,prevent |
R3295 | T12375 | T12374 | compound | Figure,3C |
R3296 | T12376 | T12374 | punct | ),3C |
R3297 | T12377 | T12363 | punct | .,recovered |
R3298 | T12239 | T12230 | neg | not,prevent |
R3299 | T12240 | T12241 | amod | embryonic,development |
R3300 | T12241 | T12230 | dobj | development,prevent |
R3301 | T12242 | T12230 | punct | .,prevent |
R3302 | T12379 | T12380 | det | These,data |
R3303 | T12380 | T12381 | nsubj | data,demonstrate |
R3304 | T12244 | T12245 | nsubj | RMCE,was |
R3305 | T12382 | T12383 | mark | that,is |
R3306 | T12383 | T12381 | ccomp | is,demonstrate |
R3307 | T12384 | T12385 | npadvmod | marker,free |
R3308 | T12246 | T12244 | prep | with,RMCE |
R3309 | T12385 | T12387 | amod | free,RMCE |
R3310 | T12386 | T12385 | punct | -,free |
R3311 | T12387 | T12383 | nsubj | RMCE,is |
R3312 | T12388 | T12389 | advmod | very,efficient |
R3313 | T12247 | T12248 | det | a,plasmid |
R3314 | T12389 | T12383 | acomp | efficient,is |
R3315 | T12390 | T12383 | prep | in,is |
R3316 | T12391 | T12392 | compound | ES,cells |
R3317 | T12248 | T12246 | pobj | plasmid,with |
R3318 | T12392 | T12390 | pobj | cells,in |
R3319 | T12393 | T12383 | cc | and,is |
R3320 | T12394 | T12383 | conj | allows,is |
R3321 | T12249 | T12248 | compound | p53ΔPGFP,plasmid |
R3322 | T12395 | T12396 | compound | germline,transmission |
R3323 | T12396 | T12394 | dobj | transmission,allows |
R3324 | T12397 | T12396 | prep | of,transmission |
R3325 | T12250 | T12248 | compound | replacement,plasmid |
R3326 | T12398 | T12399 | det | a,mutation |
R3327 | T12399 | T12397 | pobj | mutation,of |
R3328 | T12251 | T12245 | advmod | again,was |
R3329 | T12400 | T12399 | amod | targeted,mutation |
R3330 | T12401 | T12402 | punct | (,see |
R3331 | T12402 | T12394 | parataxis | see,allows |
R3332 | T12252 | T12253 | advmod | very,efficient |
R3333 | T12403 | T12402 | dobj | Figure,see |
R3334 | T12404 | T12403 | nummod | 1,Figure |
R3335 | T12405 | T12403 | punct | ", ",Figure |
R3336 | T12253 | T12245 | acomp | efficient,was |
R3337 | T12406 | T12407 | compound | path,A |
R3338 | T12407 | T12403 | appos | A,Figure |
R3339 | T12254 | T12245 | cc | and,was |
R3340 | T12408 | T12402 | punct | ),see |
R3341 | T12409 | T12381 | punct | .,demonstrate |
R3343 | T12255 | T12256 | compound | western,blots |
R3347 | T12256 | T12257 | nsubj | blots,revealed |
R3351 | T12257 | T12245 | conj | revealed,was |
R3355 | T12258 | T12259 | det | an,band |
R3359 | T12259 | T12257 | dobj | band,revealed |
R3363 | T12260 | T12259 | amod | additional,band |
R3367 | T12261 | T12259 | prep | of,band |
R3371 | T12262 | T12263 | det | the,weight |
R3375 | T12263 | T12261 | pobj | weight,of |
R3378 | T12264 | T12263 | amod | predicted,weight |
R3380 | T12265 | T12263 | amod | molecular,weight |
R3383 | T12266 | T12267 | advmod | only,in |
R3384 | T12267 | T12257 | prep | in,revealed |
R3387 | T12268 | T12269 | nmod | p53,ΔPGFP |
R3390 | T12269 | T12272 | compound | ΔPGFP,cells |
R3397 | T12270 | T12269 | punct | +,ΔPGFP |
R3401 | T12271 | T12269 | punct | /,ΔPGFP |
R3405 | T12272 | T12267 | pobj | cells,in |
craft-ca-core-ex-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11496 | 51-54 | PR_EXT:000003035 | denotes | p53 |
T11497 | 55-66 | SO_EXT:fusion_gene_or_gene_fusion | denotes | fusion gene |
T11498 | 80-83 | PR_EXT:000003035 | denotes | p53 |
T11499 | 84-91 | CHEBI_SO_EXT:proline | denotes | proline |
T11500 | 97-103 | SO_EXT:0000417 | denotes | domain |
T11501 | 114-121 | SO_EXT:sequence_deletion_process | denotes | deleted |
T11502 | 123-126 | PR_EXT:000003035 | denotes | p53 |
T11503 | 139-142 | PR_EXT:000003035 | denotes | p53 |
T11504 | 149-154 | SO_EXT:sequence_fusion_process | denotes | fused |
T11505 | 176-182 | SO_EXT:sequence_altered_entity | denotes | mutant |
T11506 | 191-199 | SO_EXT:sequence_deletion_process | denotes | deleting |
T11507 | 204-211 | CHEBI_SO_EXT:proline | denotes | proline |
T11508 | 217-223 | SO_EXT:0000417 | denotes | domain |
T11509 | 260-263 | CHEBI_SO_EXT:DNA | denotes | DNA |
T11510 | 271-280 | GO_EXT:reaction_or_response | denotes | responses |
T11511 | 340-346 | SO_EXT:sequence_altered_entity | denotes | mutant |
T11512 | 366-375 | UBERON:0000922 | denotes | embryonic |
T11513 | 366-387 | GO:0009790 | denotes | embryonic development |
T11514 | 401-404 | PR_EXT:000003035 | denotes | p53 |
T11515 | 410-421 | SO_EXT:sequence_substitution_entity_or_process | denotes | replacement |
T11516 | 422-429 | SO_EXT:0000155 | denotes | plasmid |
T11517 | 518-527 | CHEBI_EXT:polyatomic_entity_or_group | denotes | molecular |
T11518 | 543-546 | PR_EXT:000003035 | denotes | p53 |
T11519 | 546-547 | SO_EXT:normal_or_wild_type_or_present | denotes | + |
T11520 | 554-562 | CL:0002322 | denotes | ES cells |
T11521 | 557-562 | CL_GO_EXT:cell | denotes | cells |
T11522 | 597-605 | SO_EXT:sequence_deletion_entity_or_process | denotes | deletion |
T11523 | 628-638 | GO:0010467 | denotes | expression |
T11524 | 647-650 | PR_EXT:000003035 | denotes | p53 |
T11525 | 684-687 | PR_EXT:000003035 | denotes | p53 |
T11526 | 687-689 | SO_EXT:wild_type_entity_or_quality | denotes | WT |
T11527 | 697-700 | PR_EXT:000003035 | denotes | p53 |
T11528 | 700-701 | SO_EXT:normal_or_wild_type_or_present | denotes | + |
T11529 | 708-714 | SO_EXT:sequence_cloned_entity | denotes | clones |
T11530 | 755-758 | PR_EXT:000003035 | denotes | p53 |
T11531 | 758-759 | SO_EXT:normal_or_wild_type_or_present | denotes | + |
T11532 | 766-774 | CL:0002322 | denotes | ES cells |
T11533 | 769-774 | CL_GO_EXT:cell | denotes | cells |
T11534 | 799-803 | NCBITaxon:10088 | denotes | mice |
T11535 | 821-829 | SO_EXT:sequence_alteration_process | denotes | modified |
T11536 | 830-836 | SO_EXT:0001023 | denotes | allele |
T11537 | 863-866 | PR_EXT:000003035 | denotes | p53 |
T11538 | 866-867 | SO_EXT:normal_or_wild_type_or_present | denotes | + |
T11539 | 874-881 | CL:0002322 | denotes | ES cell |
T11540 | 877-881 | CL_GO_EXT:cell | denotes | cell |
T11541 | 882-888 | SO_EXT:sequence_cloned_entity | denotes | clones |
T11542 | 908-919 | UBERON:0000358 | denotes | blastocysts |
T11543 | 947-951 | NCBITaxon:10088 | denotes | mice |
T11544 | 980-984 | NCBITaxon_UBERON_EXT:pup | denotes | pups |
T11545 | 1009-1015 | GO:0007618 | denotes | mating |
T11546 | 1034-1036 | SO_EXT:wild_type_entity_or_quality | denotes | WT |
T11547 | 1037-1041 | NCBITaxon:10088 | denotes | mice |
T11548 | 1083-1089 | CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag | denotes | marker |
T11549 | 1121-1129 | CL:0002322 | denotes | ES cells |
T11550 | 1124-1129 | CL_GO_EXT:cell | denotes | cells |
T11551 | 1177-1185 | SO_EXT:sequence_alteration_entity_or_process | denotes | mutation |
craft-ca-core-dev
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T11304 | 51-54 | PR:000003035 | denotes | p53 |
T11305 | 80-83 | PR:000003035 | denotes | p53 |
T11306 | 97-103 | SO:0000417 | denotes | domain |
T11307 | 123-126 | PR:000003035 | denotes | p53 |
T11308 | 139-142 | PR:000003035 | denotes | p53 |
T11309 | 217-223 | SO:0000417 | denotes | domain |
T11310 | 366-375 | UBERON:0000922 | denotes | embryonic |
T11311 | 366-387 | GO:0009790 | denotes | embryonic development |
T11312 | 401-404 | PR:000003035 | denotes | p53 |
T11313 | 422-429 | SO:0000155 | denotes | plasmid |
T11314 | 543-546 | PR:000003035 | denotes | p53 |
T11315 | 554-562 | CL:0002322 | denotes | ES cells |
T11316 | 628-638 | GO:0010467 | denotes | expression |
T11317 | 647-650 | PR:000003035 | denotes | p53 |
T11318 | 684-687 | PR:000003035 | denotes | p53 |
T11319 | 697-700 | PR:000003035 | denotes | p53 |
T11322 | 799-803 | NCBITaxon:10088 | denotes | mice |
T11323 | 830-836 | SO:0001023 | denotes | allele |
T11324 | 863-866 | PR:000003035 | denotes | p53 |
T11325 | 874-881 | CL:0002322 | denotes | ES cell |
T11326 | 908-919 | UBERON:0000358 | denotes | blastocysts |
T11327 | 947-951 | NCBITaxon:10088 | denotes | mice |
T11328 | 1009-1015 | GO:0007618 | denotes | mating |
T11329 | 1037-1041 | NCBITaxon:10088 | denotes | mice |
T11330 | 1121-1129 | CL:0002322 | denotes | ES cells |
T11320 | 755-758 | PR:000003035 | denotes | p53 |
T11321 | 766-774 | CL:0002322 | denotes | ES cells |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
16870721-16616333-76660906 | 290-291 | 16616333 | denotes | 5 |