PMC:1540739 / 1375-1565 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T2614","span":{"begin":0,"end":190},"obj":"sentence"},{"id":"T2615","span":{"begin":1,"end":3},"obj":"IN"},{"id":"T2616","span":{"begin":44,"end":50},"obj":"VBN"},{"id":"T2617","span":{"begin":4,"end":10},"obj":"JJ"},{"id":"T2618","span":{"begin":11,"end":16},"obj":"NNS"},{"id":"T2619","span":{"begin":16,"end":18},"obj":","},{"id":"T2620","span":{"begin":18,"end":22},"obj":"DT"},{"id":"T2621","span":{"begin":23,"end":25},"obj":"IN"},{"id":"T2622","span":{"begin":26,"end":31},"obj":"DT"},{"id":"T2623","span":{"begin":32,"end":38},"obj":"NNS"},{"id":"T2624","span":{"begin":39,"end":43},"obj":"VBD"},{"id":"T2625","span":{"begin":51,"end":53},"obj":"FW"},{"id":"T2626","span":{"begin":54,"end":58},"obj":"FW"},{"id":"T2627","span":{"begin":59,"end":61},"obj":"IN"},{"id":"T2628","span":{"begin":62,"end":71},"obj":"VBG"},{"id":"T2629","span":{"begin":72,"end":78},"obj":"JJ"},{"id":"T2630","span":{"begin":79,"end":88},"obj":"NNS"},{"id":"T2631","span":{"begin":89,"end":91},"obj":"IN"},{"id":"T2632","span":{"begin":92,"end":95},"obj":"DT"},{"id":"T2633","span":{"begin":100,"end":105},"obj":"NN"},{"id":"T2634","span":{"begin":96,"end":99},"obj":"NN"},{"id":"T2635","span":{"begin":106,"end":111},"obj":"VBG"},{"id":"T2636","span":{"begin":112,"end":122},"obj":"JJ"},{"id":"T2637","span":{"begin":123,"end":136},"obj":"NN"},{"id":"T2638","span":{"begin":137,"end":139},"obj":"IN"},{"id":"T2639","span":{"begin":140,"end":149},"obj":"JJ"},{"id":"T2640","span":{"begin":150,"end":154},"obj":"NN"},{"id":"T2641","span":{"begin":160,"end":165},"obj":"NNS"},{"id":"T2642","span":{"begin":155,"end":156},"obj":"-LRB-"},{"id":"T2643","span":{"begin":156,"end":158},"obj":"NN"},{"id":"T2644","span":{"begin":158,"end":159},"obj":"-RRB-"},{"id":"T2645","span":{"begin":166,"end":168},"obj":"TO"},{"id":"T2646","span":{"begin":169,"end":177},"obj":"VB"},{"id":"T2647","span":{"begin":178,"end":184},"obj":"JJ"},{"id":"T2648","span":{"begin":185,"end":189},"obj":"NNS"},{"id":"T2649","span":{"begin":189,"end":190},"obj":"."}],"relations":[{"id":"R244","pred":"prep","subj":"T2615","obj":"T2616"},{"id":"R245","pred":"amod","subj":"T2617","obj":"T2618"},{"id":"R246","pred":"pobj","subj":"T2618","obj":"T2615"},{"id":"R247","pred":"punct","subj":"T2619","obj":"T2616"},{"id":"R248","pred":"nsubjpass","subj":"T2620","obj":"T2616"},{"id":"R249","pred":"prep","subj":"T2621","obj":"T2620"},{"id":"R250","pred":"det","subj":"T2622","obj":"T2623"},{"id":"R251","pred":"pobj","subj":"T2623","obj":"T2621"},{"id":"R252","pred":"auxpass","subj":"T2624","obj":"T2616"},{"id":"R253","pred":"advmod","subj":"T2625","obj":"T2626"},{"id":"R254","pred":"advmod","subj":"T2626","obj":"T2616"},{"id":"R255","pred":"prep","subj":"T2627","obj":"T2616"},{"id":"R256","pred":"pcomp","subj":"T2628","obj":"T2627"},{"id":"R257","pred":"amod","subj":"T2629","obj":"T2630"},{"id":"R258","pred":"dobj","subj":"T2630","obj":"T2628"},{"id":"R259","pred":"prep","subj":"T2631","obj":"T2628"},{"id":"R260","pred":"det","subj":"T2632","obj":"T2633"},{"id":"R261","pred":"pobj","subj":"T2633","obj":"T2631"},{"id":"R263","pred":"compound","subj":"T2634","obj":"T2633"},{"id":"R265","pred":"advcl","subj":"T2635","obj":"T2628"},{"id":"R268","pred":"amod","subj":"T2636","obj":"T2637"},{"id":"R270","pred":"dobj","subj":"T2637","obj":"T2635"},{"id":"R274","pred":"prep","subj":"T2638","obj":"T2635"},{"id":"R277","pred":"amod","subj":"T2639","obj":"T2640"},{"id":"R281","pred":"nmod","subj":"T2640","obj":"T2641"},{"id":"R283","pred":"pobj","subj":"T2641","obj":"T2638"},{"id":"R285","pred":"punct","subj":"T2642","obj":"T2640"},{"id":"R288","pred":"appos","subj":"T2643","obj":"T2640"},{"id":"R293","pred":"punct","subj":"T2644","obj":"T2641"},{"id":"R296","pred":"aux","subj":"T2645","obj":"T2646"},{"id":"R303","pred":"advcl","subj":"T2646","obj":"T2635"},{"id":"R305","pred":"amod","subj":"T2647","obj":"T2648"},{"id":"R311","pred":"dobj","subj":"T2648","obj":"T2646"},{"id":"R313","pred":"punct","subj":"T2649","obj":"T2616"}],"text":" In recent years, some of these models were tested in vivo by targeting subtle mutations at the p53 locus using homologous recombination in embryonic stem (ES) cells to generate mutant mice."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2425","span":{"begin":79,"end":88},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T2426","span":{"begin":96,"end":99},"obj":"PR_EXT:000003035"},{"id":"T2427","span":{"begin":123,"end":136},"obj":"GO_SO_EXT:sequence_rearrangement_process"},{"id":"T2428","span":{"begin":140,"end":149},"obj":"UBERON:0000922"},{"id":"T2429","span":{"begin":140,"end":154},"obj":"_FRAGMENT"},{"id":"T2430","span":{"begin":160,"end":165},"obj":"CL:0002322"},{"id":"T2431","span":{"begin":156,"end":158},"obj":"_FRAGMENT"},{"id":"T2432","span":{"begin":160,"end":165},"obj":"CL_GO_EXT:cell"},{"id":"T2433","span":{"begin":178,"end":184},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T2434","span":{"begin":185,"end":189},"obj":"NCBITaxon:10088"}],"relations":[{"id":"R200","pred":"_lexicallyChainedTo","subj":"T2430","obj":"T2429"},{"id":"R201","pred":"_lexicallyChainedTo","subj":"T2430","obj":"T2431"}],"text":" In recent years, some of these models were tested in vivo by targeting subtle mutations at the p53 locus using homologous recombination in embryonic stem (ES) cells to generate mutant mice."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T2338","span":{"begin":96,"end":99},"obj":"PR:000003035"},{"id":"T2339","span":{"begin":140,"end":149},"obj":"UBERON:0000922"},{"id":"T2340","span":{"begin":140,"end":154},"obj":"_FRAGMENT"},{"id":"T2341","span":{"begin":160,"end":165},"obj":"CL:0002322"},{"id":"T2342","span":{"begin":156,"end":158},"obj":"_FRAGMENT"},{"id":"T2343","span":{"begin":185,"end":189},"obj":"NCBITaxon:10088"}],"relations":[{"id":"R196","pred":"_lexicallyChainedTo","subj":"T2341","obj":"T2340"},{"id":"R197","pred":"_lexicallyChainedTo","subj":"T2341","obj":"T2342"}],"text":" In recent years, some of these models were tested in vivo by targeting subtle mutations at the p53 locus using homologous recombination in embryonic stem (ES) cells to generate mutant mice."}