PMC:1540429 / 10260-10738 JSONTXT

{"project":"2_test","denotations":[{"id":"16722558-10902194-1694717","span":{"begin":378,"end":379},"obj":"10902194"}],"text":"Another type of objective function emphasizes the likelihood that most, if not all, sequences are potentially bound by the transcription factor. That means a prediction having multiple binding sites in one sequence and none in the others is much less significant than a prediction having a balanced number of binding sites in each sequence. This idea is designed into ANN-Spec [6] and Weeder [7]. The objective function, named sequence specificity, is defined in [7] as follows."}