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2_test

Id Subject Object Predicate Lexical cue
16507151-3226317-4304428 1743-1744 3226317 denotes 1
16507151-3192274-4304428 1743-1744 3192274 denotes 1
16507151-16171986-4304428 1743-1744 16171986 denotes 1
16507151-1563036-4304429 1859-1860 1563036 denotes 4
16507151-6857175-4304430 2007-2008 6857175 denotes 5
16507151-1734904-4304431 2213-2214 1734904 denotes 6
16507151-3608230-4304432 2215-2216 3608230 denotes 7
16507151-11959763-4304433 2368-2369 11959763 denotes 8
16507151-15286392-4304434 3024-3025 15286392 denotes 9
16507151-16171986-4304435 3124-3125 16171986 denotes 3
16507151-15286392-4304436 3126-3127 15286392 denotes 9
16507151-6857175-4304437 3214-3215 6857175 denotes 5
16507151-2070561-4304438 3216-3218 2070561 denotes 10
16507151-3608230-4304439 3265-3266 3608230 denotes 7
16507151-2070561-4304440 3267-3269 2070561 denotes 10
16507151-1571479-4304441 3270-3272 1571479 denotes 11
16507151-2070561-4304442 3460-3462 2070561 denotes 10
16507151-1571479-4304443 3516-3518 1571479 denotes 11
16507151-1870982-4304444 7056-7058 1870982 denotes 12
16507151-6999296-4304445 9211-9213 6999296 denotes 14
16507151-8026530-4304446 12855-12857 8026530 denotes 15
16507151-11959763-4304447 14161-14162 11959763 denotes 8
16507151-3608230-4304448 14411-14412 3608230 denotes 7
16507151-2070561-4304449 14413-14415 2070561 denotes 10
16507151-1571479-4304450 14416-14418 1571479 denotes 11
16507151-12594249-4304451 14732-14734 12594249 denotes 16
16507151-12594249-4304452 14753-14755 12594249 denotes 16
16507151-11433381-4304453 14776-14778 11433381 denotes 17
16507151-15210771-4304454 15084-15086 15210771 denotes 18
16507151-15210771-4304455 15291-15293 15210771 denotes 18
16507151-15529344-4304456 15442-15444 15529344 denotes 19
16507151-15507872-4304457 16143-16145 15507872 denotes 20
16507151-12517969-4304457 16143-16145 12517969 denotes 20
16507151-10934166-4304457 16143-16145 10934166 denotes 20
16507151-12794840-4304458 16369-16371 12794840 denotes 23
16507151-11555626-4304459 16538-16540 11555626 denotes 24
16507151-15529344-4304460 17816-17818 15529344 denotes 19

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T488 18-26 CHEBI_PR_EXT:collagen denotes collagen
T489 53-57 GO_PATO_EXT:aging_or_agedness denotes aged
T490 70-76 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T491 77-81 NCBITaxon:10088 denotes mice
T492 92-100 CHEBI_PR_EXT:collagen denotes Collagen
T493 122-126 NCBITaxon:10088 denotes mice
T494 164-170 UBERON:0002405 denotes immune
T495 246-254 CHEBI_PR_EXT:collagen denotes collagen
T496 290-295 SO_EXT:0000704 denotes genic
T497 364-375 GO:0065007 denotes controlling
T498 376-381 SO_EXT:0000704 denotes genes
T499 433-437 GO_PATO_EXT:aging_or_agedness denotes aged
T500 438-443 NCBITaxon_UBERON_EXT:woman denotes women
T501 489-496 SO_EXT:0000704 denotes genetic
T502 518-526 CHEBI_PR_EXT:collagen denotes collagen
T503 557-561 GO_PATO_EXT:aging_or_agedness denotes aged
T504 562-568 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T505 569-573 NCBITaxon:10088 denotes mice
T506 615-624 SO_EXT:0001024 denotes haplotype
T507 631-635 NCBITaxon:10088 denotes mice
T508 671-683 GO:0000003 denotes reproductive
T509 794-800 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T510 801-805 NCBITaxon:10088 denotes mice
T511 827-833 SO_EXT:0001026 denotes genome
T512 858-872 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T513 873-880 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T514 911-935 SO_EXT:0000771 denotes quantitative trait locus
T515 1000-1010 GO_SO_EXT:chromosome denotes chromosome
T516 1039-1048 GO_PATO_EXT:biological_localization_process_or_quality denotes localizes
T517 1062-1073 GO:0065007 denotes controlling
T518 1074-1083 GO:0007565 denotes pregnancy
T519 1108-1132 SO_EXT:0000771 denotes quantitative trait locus
T520 1235-1245 GO_SO_EXT:chromosome denotes chromosome
T521 1285-1309 SO_EXT:0000771 denotes quantitative trait locus
T522 1326-1334 CHEBI_PR_EXT:collagen denotes collagen
T523 1326-1342 PR_EXT:000003266 denotes collagen type II
T524 1343-1351 GO:0042571 denotes antibody
T525 1377-1387 GO_SO_EXT:chromosome denotes chromosome
T526 1426-1430 SO_EXT:0000704 denotes gene
T527 1436-1443 GO:0065007 denotes control
T528 1457-1461 GO_PATO_EXT:aging_or_agedness denotes aged
T529 1474-1481 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T530 1534-1543 GO:0007565 denotes pregnancy
T1793 1621-1624 NCBITaxon:9606 denotes man
T1794 1629-1637 CHEBI_PR_EXT:collagen denotes collagen
T1795 1665-1669 NCBITaxon:10088 denotes mice
T1796 1787-1792 NCBITaxon_UBERON_EXT:woman denotes women
T1797 1796-1808 GO:0000003 denotes reproductive
T1798 1854-1857 NCBITaxon_UBERON_EXT:man denotes men
T1799 1901-1907 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1800 1931-1938 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T1801 1996-2005 GO:0007565 denotes pregnancy
T1802 2133-2142 GO:0007565 denotes pregnancy
T1803 2172-2178 GO:0007567 denotes partum
T1804 2258-2263 NCBITaxon_UBERON_EXT:woman denotes women
T1805 2288-2297 GO:0007565 denotes pregnancy
T1806 2362-2366 UBERON:0000104 denotes life
T1807 2381-2387 NCBITaxon:33208 denotes animal
T1808 2438-2443 SO_EXT:0000704 denotes genes
T1809 2464-2469 NCBITaxon:9606 denotes human
T1810 2487-2491 NCBITaxon:10088 denotes mice
T1811 2556-2561 NCBITaxon:9606 denotes human
T1812 2626-2631 SO_EXT:0000704 denotes genes
T1813 2819-2823 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T1814 2828-2834 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1815 2849-2853 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes Male
T1816 2854-2858 NCBITaxon:10088 denotes mice
T1817 2888-2895 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T1819 2988-2996 CHEBI_GO_EXT:hormone denotes hormonal
T1820 3001-3011 GO_PATO_EXT:biological_behavior denotes behavioral
T1821 3109-3115 NCBITaxon:33208 denotes animal
T1822 3130-3139 GO:0007565 denotes Pregnancy
T1823 3143-3147 NCBITaxon:10088 denotes mice
T1824 3154-3163 GO:0007565 denotes pregnancy
T1825 3167-3172 NCBITaxon_UBERON_EXT:woman denotes women
T1826 3257-3263 GO:0007567 denotes partum
T1827 3275-3284 GO:0007565 denotes Pregnancy
T1828 3313-3317 NCBITaxon:10088 denotes mice
T1829 3358-3366 CHEBI_EXT:50114 denotes estrogen
T1830 3389-3395 GO:0007567 denotes partum
T1831 3450-3458 CHEBI_EXT:50114 denotes estrogen
T1832 3498-3507 CHEBI_PR_EXT:prolactin denotes prolactin
T1833 3540-3549 GO:0007565 denotes pregnancy
T1834 3605-3609 UBERON:0000104 denotes life
T1835 3702-3707 NCBITaxon_UBERON_EXT:woman denotes women
T1836 3740-3748 NCBITaxon_UBERON_EXT:child denotes children
T1837 3817-3823 NCBITaxon:33208 denotes animal
T1838 3870-3876 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1839 3877-3881 NCBITaxon:10088 denotes mice
T1840 3914-3926 GO:0000003 denotes reproductive
T1841 4057-4063 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1842 4064-4068 NCBITaxon:10088 denotes mice
T1843 4172-4179 SO_EXT:0000704 denotes genetic
T1844 4180-4187 GO:0065007 denotes control
T1845 4198-4202 GO_PATO_EXT:aging_or_agedness denotes aged
T1846 4203-4210 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T2714 4518-4522 NCBITaxon:10088 denotes mice
T2715 4528-4532 GO_EXT:breeding denotes bred
T2716 4583-4589 NCBITaxon:33208 denotes animal
T2717 4610-4616 NCBITaxon:33208 denotes animal
T2718 4684-4691 NCBITaxon:33208 denotes animals
T2719 4697-4700 GO:0007631 denotes fed
T2720 4726-4732 NCBITaxon:9989 denotes rodent
T2721 4733-4737 CHEBI_EXT:33290 denotes chow
T2722 4763-4771 GO_EXT:breeding denotes breeding
T2723 4772-4776 CHEBI_EXT:33290 denotes food
T2724 4781-4785 NCBITaxon:10114 denotes rats
T2725 4790-4794 NCBITaxon:10088 denotes mice
T2726 4832-4837 CHEBI:15377 denotes water
T2727 4892-4896 NCBITaxon:10088 denotes mice
T2728 5012-5018 NCBITaxon:33208 denotes Animal
T2729 5091-5097 UBERON:0000922 denotes embryo
T2730 5098-5106 GO_EXT:biological_movement_or_translocation_process denotes transfer
T2731 5121-5133 GO:0000003 denotes reproduction
T3123 5399-5403 NCBITaxon:10088 denotes mice
T3124 5420-5424 GO:0007618 denotes mate
T3125 5445-5450 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T3126 5463-5469 GO:0007618 denotes mating
T3127 5482-5485 GO:0042611 denotes MHC
T3128 5487-5519 GO:0042611 denotes major histocompatibility complex
T3129 5536-5540 GO:0007618 denotes mate
T3130 5558-5563 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes males
T3131 5575-5581 GO:0007618 denotes mating
T3132 5594-5597 GO:0042611 denotes MHC
T3133 5620-5631 GO:0007565 denotes pregnancies
T3134 5655-5661 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T3135 5662-5666 NCBITaxon:10088 denotes mice
T3681 5720-5724 NCBITaxon:10088 denotes mice
T3682 5743-5754 UBERON_EXT:zone_of_skin_or_skin_of_body denotes cutaneously
T3683 5774-5778 UBERON:0002415 denotes tail
T3684 5791-5794 NCBITaxon:10114 denotes rat
T3685 5795-5803 CHEBI_PR_EXT:collagen denotes collagen
T3686 5795-5811 PR_EXT:000003266 denotes collagen type II
T3687 5813-5816 PR_EXT:000003266 denotes CII
T3688 5838-5849 CHEBI:15366 denotes acetic acid
T3689 5900-5908 CHEBI_EXT:60809 denotes adjuvant
T3690 5986-5989 PR_EXT:000003266 denotes CII
T3691 6010-6021 CHEBI:15366 denotes acetic acid
T3692 6074-6082 CHEBI_EXT:60809 denotes adjuvant
T3693 6211-6218 NCBITaxon:33208 denotes Animals
T3694 6358-6363 NCBITaxon:10088 denotes mouse
T3695 6465-6470 UBERON:0004905 denotes joint
T3696 6476-6488 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T3697 6501-6507 UBERON:0004905 denotes joints
T3698 6524-6536 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T3699 6551-6554 UBERON_EXT:paw denotes paw
T3700 6562-6571 UBERON:0001447 denotes anklebone
T3701 6578-6581 UBERON_EXT:paw denotes paw
T3702 6649-6653 UBERON_EXT:paw denotes paws
T3703 6723-6729 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T3704 6864-6871 NCBITaxon:33208 denotes animals
T4703 6874-6888 SO_EXT:microsatellite_unit_or_region denotes Microsatellite
T4704 6921-6925 UBERON:0002415 denotes Tail
T4705 6962-6969 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T4706 6993-6996 CHEBI_SO_EXT:DNA denotes DNA
T4707 7089-7092 CHEBI_SO_EXT:DNA denotes DNA
T4708 7116-7121 NCBITaxon:10088 denotes mouse
T4709 7135-7142 CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process denotes labeled
T4710 7143-7157 SO_EXT:microsatellite_unit_or_region denotes microsatellite
T4711 7158-7165 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4712 7211-7218 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4713 7246-7252 SO_EXT:0001026 denotes genome
T4714 7286-7290 NCBITaxon:10088 denotes mice
T4715 7311-7318 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4716 7332-7343 GO_SO_EXT:chromosome denotes chromosomes
T4717 7359-7371 GO:0000806 denotes Y chromosome
T4718 7361-7371 GO_SO_EXT:chromosome denotes chromosome
T4719 7399-7406 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T4720 7499-7502 CHEBI_SO_EXT:DNA denotes DNA
T4721 7510-7513 CHEBI:32588 denotes KCl
T4722 7521-7525 CHEBI:9754 denotes Tris
T4723 7526-7529 CHEBI:17883 denotes HCl
T4724 7537-7546 CHEBI:62946 denotes (NH4)2SO4
T4725 7553-7558 CHEBI:6636 denotes MgCl2
T4726 7565-7577 CHEBI:9750 denotes Triton X-100
T4727 7652-7658 SO_EXT:0000112 denotes primer
T4728 7665-7670 CHEBI_EXT:dNTP denotes dNTPs
T4729 7728-7731 NCBITaxon:271 denotes Taq
T4730 7732-7735 CHEBI_SO_EXT:DNA denotes DNA
T4731 7732-7746 GO_EXT:0034061 denotes DNA Polymerase
T4732 7821-7824 CHEBI_SO_EXT:DNA denotes DNA
T4733 7826-7838 GO_EXT:macromolecule_denaturation denotes denaturation
T4734 7862-7871 GO:0097617 denotes annealing
T4735 7896-7910 MOP:0000629 denotes polymerization
T4736 8063-8075 SO_EXT:0000006 denotes PCR products
T4737 8229-8236 SO_EXT:0000704 denotes Genetic
T4738 8407-8412 NCBITaxon:10088 denotes mouse
T4739 8413-8419 SO_EXT:0001026 denotes genome
T4740 8444-8450 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T4741 8465-8471 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T5418 9016-9022 CHEBI_GO_SO_EXT:enzyme denotes Enzyme
T5419 9054-9059 UBERON:0007023 denotes adult
T5420 9060-9066 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T5421 9067-9071 NCBITaxon:10088 denotes mice
T5422 9077-9087 GO_EXT:killing denotes sacrificed
T5423 9112-9116 UBERON:0001977 denotes sera
T5424 9138-9141 PR_EXT:000003266 denotes CII
T5425 9142-9150 GO:0042571 denotes antibody
T5426 9226-9229 PR_EXT:000003266 denotes CII
T5427 9245-9252 MOP:0000779 denotes coupled
T5428 9295-9301 NCBITaxon:27592 denotes Bovine
T5429 9302-9307 UBERON:0001977 denotes serum
T5430 9302-9315 PR_EXT:000003918 denotes serum albumin
T5431 9323-9331 CHEBI_EXT:chemical_substance_or_polyatomic_entity denotes Chemical
T5432 9420-9424 UBERON:0001977 denotes sera
T5433 9435-9440 NCBITaxon:10088 denotes mouse
T5434 9446-9449 PR_EXT:000003266 denotes CII
T5435 9450-9460 GO:0042571 denotes antibodies
T5436 9468-9472 UBERON:0001977 denotes sera
T5437 9537-9540 PR_EXT:000003266 denotes CII
T5438 9550-9553 GO:0071735 denotes IgG
T5439 9581-9591 GO_EXT:0004601 denotes peroxidase
T5440 9592-9602 MOP:0000779 denotes conjugated
T5441 9603-9607 NCBITaxon:9925 denotes goat
T5442 9618-9621 GO:0071735 denotes IgG
T5878 9800-9806 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T5879 9807-9811 NCBITaxon:10088 denotes mice
T5880 9878-9885 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T5881 9946-9950 NCBITaxon:10088 denotes mice
T5882 10132-10136 NCBITaxon:10088 denotes mice
T5883 10190-10193 UBERON_EXT:paw denotes paw
T5884 10205-10209 NCBITaxon:10088 denotes mice
T5885 10342-10345 PR_EXT:000003266 denotes CII
T5886 10468-10474 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T5887 10475-10479 NCBITaxon:10088 denotes mice
T6394 10496-10505 GO:0007565 denotes Pregnancy
T6395 10576-10582 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6396 10583-10587 NCBITaxon:10088 denotes mice
T6397 10597-10604 SO_EXT:0000704 denotes genetic
T6398 10721-10727 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6399 10728-10732 NCBITaxon:10088 denotes mice
T6400 10815-10826 GO:0007565 denotes pregnancies
T6401 10875-10878 PR_EXT:000003266 denotes CII
T6402 10985-10996 GO:0007565 denotes pregnancies
T6403 11115-11119 NCBITaxon:10088 denotes mice
T6404 11134-11138 NCBITaxon:10088 denotes mice
T6405 11169-11180 GO:0007565 denotes pregnancies
T6406 11229-11233 NCBITaxon:10088 denotes mice
T6407 11264-11273 GO:0007565 denotes pregnancy
T6408 11341-11347 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6409 11348-11352 NCBITaxon:10088 denotes mice
T6410 11373-11381 GO:0007565 denotes pregnant
T6411 11387-11390 GO:0042611 denotes MHC
T6412 11423-11429 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6413 11430-11434 NCBITaxon:10088 denotes mice
T6414 11455-11463 GO:0007565 denotes pregnant
T6415 11469-11472 GO:0042611 denotes MHC
T6842 11544-11550 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T6843 11551-11555 NCBITaxon:10088 denotes mice
T6844 11560-11567 SO_EXT:0000704 denotes genetic
T6845 11610-11634 SO_EXT:0000771 denotes quantitative trait locus
T6846 11636-11639 SO_EXT:0000771 denotes QTL
T6847 11664-11674 GO_SO_EXT:chromosome denotes chromosome
T6848 11906-11909 SO_EXT:0000771 denotes QTL
T6849 11997-12007 GO_SO_EXT:chromosome denotes chromosome
T6850 12044-12047 SO_EXT:0000771 denotes QTL
T6851 12067-12070 PR_EXT:000003266 denotes CII
T6852 12071-12079 GO:0042571 denotes antibody
T6853 12104-12114 GO_SO_EXT:chromosome denotes chromosome
T8924 12185-12188 GO:0042611 denotes MHC
T8925 12217-12221 NCBITaxon:10088 denotes mice
T8926 12267-12272 NCBITaxon:10088 denotes mouse
T8927 12298-12303 NCBITaxon:10088 denotes mouse
T8928 12316-12325 SO_EXT:0001024 denotes haplotype
T8929 12360-12365 NCBITaxon:10088 denotes mouse
T8930 12413-12421 GO_EXT:breeding denotes breeding
T8931 12438-12442 NCBITaxon:10088 denotes mice
T8932 12494-12501 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T8933 12521-12528 SO_EXT:0000704 denotes genetic
T8934 12538-12550 GO:0000003 denotes reproduction
T8935 12594-12602 GO_EXT:breeding denotes breeding
T8936 12828-12840 GO:0042613 denotes MHC class II
T8937 12828-12847 PR_EXT:000001821 denotes MHC class II A beta
T8938 12848-12853 SO_EXT:0000704 denotes genes
T8939 12900-12912 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T8940 12924-12928 NCBITaxon:10088 denotes mice
T8941 13003-13010 SO_EXT:0000704 denotes genetic
T8942 13011-13018 GO:0065007 denotes control
T8943 13035-13039 GO_PATO_EXT:aging_or_agedness denotes aged
T8944 13052-13059 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes females
T8945 13083-13088 NCBITaxon:9606 denotes human
T8946 13181-13185 NCBITaxon:10088 denotes mice
T8947 13204-13216 GO:0000003 denotes reproductive
T8948 13417-13421 NCBITaxon:10088 denotes mice
T8949 13449-13453 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T8950 13454-13458 NCBITaxon:10088 denotes mice
T8951 13510-13514 NCBITaxon:10088 denotes mice
T8952 13548-13553 NCBITaxon_UBERON_EXT:woman denotes women
T8953 13744-13755 SO_EXT:polymorphism denotes polymorphic
T8954 13756-13761 SO_EXT:0000704 denotes genes
T8955 13937-13941 UBERON:0000104 denotes life
T8956 14016-14021 NCBITaxon_UBERON_EXT:woman denotes women
T8957 14077-14086 GO:0007565 denotes pregnancy
T8958 14155-14159 UBERON:0000104 denotes life
T8959 14225-14234 GO:0007565 denotes pregnancy
T8960 14344-14348 NCBITaxon:10088 denotes mice
T8961 14353-14359 NCBITaxon:9606 denotes humans
T8962 14401-14409 GO:0007567 denotes delivery
T8963 14569-14580 GO_SO_EXT:chromosome denotes chromosomes
T8964 14620-14623 PR_EXT:000003266 denotes CII
T8965 14632-14642 GO_SO_EXT:chromosome denotes chromosome
T8966 14703-14713 GO_SO_EXT:chromosome denotes chromosome
T8967 14851-14861 GO_SO_EXT:chromosome denotes chromosome
T8968 14932-14937 PR_EXT:000001852 denotes Ctla4
T8969 14939-14944 PR_EXT:000001852 denotes CD152
T8970 14946-14950 SO_EXT:0000704 denotes gene
T8971 15212-15224 SO_EXT:polymorphism denotes polymorphism
T8972 15259-15264 SO_EXT:0000704 denotes genes
T8973 15391-15394 PR_EXT:000003266 denotes CII
T8974 15395-15403 GO:0042571 denotes antibody
T8975 15395-15414 GO_EXT:antibody_or_immunoglobulin_biosynthesis_or_production denotes antibody production
T8976 15427-15437 GO_SO_EXT:chromosome denotes chromosome
T8977 15594-15597 SO_EXT:0000771 denotes QTL
T8978 15620-15630 GO_SO_EXT:chromosome denotes chromosome
T8979 15710-15720 GO_SO_EXT:chromosome denotes chromosome
T10207 17566-17570 UBERON:0000104 denotes life
T10208 17644-17654 GO_SO_EXT:chromosome denotes chromosome
T10209 17673-17683 GO_SO_EXT:chromosome denotes chromosome
T10210 17702-17712 GO_SO_EXT:chromosome denotes chromosome
T10211 17745-17748 PR_EXT:000003266 denotes CII
T2711 4263-4267 NCBITaxon:10088 denotes Mice
T2712 4281-4285 NCBITaxon:10088 denotes mice
T2713 4383-4387 NCBITaxon:10088 denotes mice
T3116 5186-5192 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T3117 5193-5197 NCBITaxon:10088 denotes mice
T3118 5284-5288 NCBITaxon:10088 denotes mice
T3119 5313-5325 GO:0000003 denotes reproductive
T3120 5343-5349 NCBITaxon:33208 denotes animal
T3121 5359-5365 GO:0007618 denotes mating
T3122 5392-5398 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T1818 2979-2986 SO_EXT:0000704 denotes genetic
T8980 15789-15799 GO_SO_EXT:chromosome denotes chromosome
T8981 15877-15880 SO_EXT:0000771 denotes QTL
T8982 15923-15933 GO_SO_EXT:chromosome denotes chromosome
T8983 15967-15972 SO_EXT:0000704 denotes genes
T8984 16032-16050 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes part of chromosome
T8985 16086-16098 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammation
T8986 16155-16158 SO_EXT:0000771 denotes QTL
T8987 16163-16175 CHEBI:37396 denotes proteoglycan
T8988 16205-16211 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T8989 16264-16274 GO_SO_EXT:chromosome denotes chromosome
T8990 16378-16383 NCBITaxon:10088 denotes mouse
T8991 16384-16394 GO_SO_EXT:chromosome denotes chromosome
T8992 16415-16420 SO_EXT:0000704 denotes genes
T8993 16437-16446 SO_EXT:biological_conservation_process_or_quality denotes conserved
T8994 16452-16457 NCBITaxon:9606 denotes human
T8995 16458-16468 GO_SO_EXT:chromosome denotes chromosome
T8996 16486-16491 NCBITaxon:9606 denotes human
T8997 16584-16591 SO_EXT:0000853 denotes homolog
T8998 16592-16595 NCBITaxon:10114 denotes rat
T8999 16596-16606 GO_SO_EXT:chromosome denotes chromosome
T9000 16617-16626 GO:0065007 denotes regulates
T9001 16775-16778 SO_EXT:0000771 denotes QTL
T9002 16809-16818 GO:0007565 denotes pregnancy
T9003 16884-16894 GO_SO_EXT:chromosome denotes chromosome
T9004 17045-17050 SO_EXT:0000704 denotes genes
T9005 17094-17098 NCBITaxon:10088 denotes mice
T9006 17137-17147 GO:0007567 denotes deliveries
T9007 17151-17157 PATO_UBERON_EXT:female_or_bearer_of_femaleness denotes female
T9008 17158-17162 NCBITaxon:10088 denotes mice
T9009 17169-17178 GO:0007565 denotes pregnancy
T9010 17188-17192 NCBITaxon:10088 denotes mice
T9011 17218-17229 GO:0007565 denotes pregnancies
T9012 17243-17255 UBERON:0010148 denotes vaginal plug
T9013 17291-17300 GO:0007565 denotes pregnancy
T9014 17347-17359 GO_PATO_EXT:inflammatory_process_or_quality denotes inflammatory
T9015 17399-17406 SO_EXT:0000704 denotes gene(s)

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T465 77-81 NCBITaxon:10088 denotes mice
T466 122-126 NCBITaxon:10088 denotes mice
T467 164-170 UBERON:0002405 denotes immune
T468 290-295 SO:0000704 denotes genic
T469 364-375 GO:0065007 denotes controlling
T470 376-381 SO:0000704 denotes genes
T471 489-496 SO:0000704 denotes genetic
T472 569-573 NCBITaxon:10088 denotes mice
T473 615-624 SO:0001024 denotes haplotype
T474 631-635 NCBITaxon:10088 denotes mice
T475 671-683 GO:0000003 denotes reproductive
T476 801-805 NCBITaxon:10088 denotes mice
T477 827-833 SO:0001026 denotes genome
T478 911-935 SO:0000771 denotes quantitative trait locus
T479 1062-1073 GO:0065007 denotes controlling
T480 1074-1083 GO:0007565 denotes pregnancy
T481 1108-1132 SO:0000771 denotes quantitative trait locus
T482 1285-1309 SO:0000771 denotes quantitative trait locus
T483 1326-1342 PR:000003266 denotes collagen type II
T484 1343-1351 GO:0042571 denotes antibody
T485 1426-1430 SO:0000704 denotes gene
T486 1436-1443 GO:0065007 denotes control
T487 1534-1543 GO:0007565 denotes pregnancy
T1759 1621-1624 NCBITaxon:9606 denotes man
T1760 1665-1669 NCBITaxon:10088 denotes mice
T1761 1796-1808 GO:0000003 denotes reproductive
T1762 1996-2005 GO:0007565 denotes pregnancy
T1763 2133-2142 GO:0007565 denotes pregnancy
T1764 2172-2178 GO:0007567 denotes partum
T1765 2288-2297 GO:0007565 denotes pregnancy
T1766 2362-2366 UBERON:0000104 denotes life
T1767 2381-2387 NCBITaxon:33208 denotes animal
T1768 2438-2443 SO:0000704 denotes genes
T1769 2464-2469 NCBITaxon:9606 denotes human
T1770 2487-2491 NCBITaxon:10088 denotes mice
T1771 2556-2561 NCBITaxon:9606 denotes human
T1784 3450-3458 CHEBI:50114 denotes estrogen
T1785 3540-3549 GO:0007565 denotes pregnancy
T1786 3605-3609 UBERON:0000104 denotes life
T1787 3817-3823 NCBITaxon:33208 denotes animal
T1788 3877-3881 NCBITaxon:10088 denotes mice
T1789 3914-3926 GO:0000003 denotes reproductive
T1790 4064-4068 NCBITaxon:10088 denotes mice
T1791 4172-4179 SO:0000704 denotes genetic
T1792 4180-4187 GO:0065007 denotes control
T2705 4790-4794 NCBITaxon:10088 denotes mice
T2706 4832-4837 CHEBI:15377 denotes water
T2707 4892-4896 NCBITaxon:10088 denotes mice
T2708 5012-5018 NCBITaxon:33208 denotes Animal
T2709 5091-5097 UBERON:0000922 denotes embryo
T2710 5121-5133 GO:0000003 denotes reproduction
T3665 5720-5724 NCBITaxon:10088 denotes mice
T3666 5774-5778 UBERON:0002415 denotes tail
T3667 5791-5794 NCBITaxon:10114 denotes rat
T3668 5795-5811 PR:000003266 denotes collagen type II
T3669 5813-5816 PR:000003266 denotes CII
T3670 5838-5849 CHEBI:15366 denotes acetic acid
T3671 5900-5908 CHEBI:60809 denotes adjuvant
T3672 5986-5989 PR:000003266 denotes CII
T3673 6010-6021 CHEBI:15366 denotes acetic acid
T3674 6074-6082 CHEBI:60809 denotes adjuvant
T3675 6211-6218 NCBITaxon:33208 denotes Animals
T3676 6358-6363 NCBITaxon:10088 denotes mouse
T3677 6465-6470 UBERON:0004905 denotes joint
T3678 6501-6507 UBERON:0004905 denotes joints
T3679 6562-6571 UBERON:0001447 denotes anklebone
T3680 6864-6871 NCBITaxon:33208 denotes animals
T4684 6921-6925 UBERON:0002415 denotes Tail
T4685 7116-7121 NCBITaxon:10088 denotes mouse
T4686 7246-7252 SO:0001026 denotes genome
T4687 7286-7290 NCBITaxon:10088 denotes mice
T4688 7359-7371 GO:0000806 denotes Y chromosome
T4689 7510-7513 CHEBI:32588 denotes KCl
T4690 7521-7525 CHEBI:9754 denotes Tris
T4691 7526-7529 CHEBI:17883 denotes HCl
T4692 7537-7546 CHEBI:62946 denotes (NH4)2SO4
T4693 7553-7558 CHEBI:6636 denotes MgCl2
T4694 7565-7577 CHEBI:9750 denotes Triton X-100
T4695 7652-7658 SO:0000112 denotes primer
T4696 7728-7731 NCBITaxon:271 denotes Taq
T4697 7862-7871 GO:0097617 denotes annealing
T4698 7896-7910 MOP:0000629 denotes polymerization
T4699 8063-8075 SO:0000006 denotes PCR products
T4700 8229-8236 SO:0000704 denotes Genetic
T4701 8407-8412 NCBITaxon:10088 denotes mouse
T4702 8413-8419 SO:0001026 denotes genome
T5400 9112-9116 UBERON:0001977 denotes sera
T5401 9138-9141 PR:000003266 denotes CII
T5402 9142-9150 GO:0042571 denotes antibody
T5403 9226-9229 PR:000003266 denotes CII
T5404 9245-9252 MOP:0000779 denotes coupled
T5405 9295-9301 NCBITaxon:27592 denotes Bovine
T5406 9302-9307 UBERON:0001977 denotes serum
T5407 9302-9315 PR:000003918 denotes serum albumin
T5408 9420-9424 UBERON:0001977 denotes sera
T5409 9435-9440 NCBITaxon:10088 denotes mouse
T5410 9446-9449 PR:000003266 denotes CII
T5411 9450-9460 GO:0042571 denotes antibodies
T5412 9468-9472 UBERON:0001977 denotes sera
T5413 9537-9540 PR:000003266 denotes CII
T5414 9550-9553 GO:0071735 denotes IgG
T5415 9592-9602 MOP:0000779 denotes conjugated
T5416 9603-9607 NCBITaxon:9925 denotes goat
T5417 9618-9621 GO:0071735 denotes IgG
T5872 9807-9811 NCBITaxon:10088 denotes mice
T5873 9946-9950 NCBITaxon:10088 denotes mice
T5874 10132-10136 NCBITaxon:10088 denotes mice
T5875 10205-10209 NCBITaxon:10088 denotes mice
T5876 10342-10345 PR:000003266 denotes CII
T5877 10475-10479 NCBITaxon:10088 denotes mice
T6376 10496-10505 GO:0007565 denotes Pregnancy
T6377 10583-10587 NCBITaxon:10088 denotes mice
T6378 10597-10604 SO:0000704 denotes genetic
T6379 10728-10732 NCBITaxon:10088 denotes mice
T6380 10815-10826 GO:0007565 denotes pregnancies
T6381 10875-10878 PR:000003266 denotes CII
T6382 10985-10996 GO:0007565 denotes pregnancies
T6383 11115-11119 NCBITaxon:10088 denotes mice
T6384 11134-11138 NCBITaxon:10088 denotes mice
T6385 11169-11180 GO:0007565 denotes pregnancies
T6386 11229-11233 NCBITaxon:10088 denotes mice
T6387 11264-11273 GO:0007565 denotes pregnancy
T6388 11348-11352 NCBITaxon:10088 denotes mice
T6389 11373-11381 GO:0007565 denotes pregnant
T6390 11387-11390 GO:0042611 denotes MHC
T6391 11430-11434 NCBITaxon:10088 denotes mice
T6392 11455-11463 GO:0007565 denotes pregnant
T6393 11469-11472 GO:0042611 denotes MHC
T6834 11551-11555 NCBITaxon:10088 denotes mice
T6835 11560-11567 SO:0000704 denotes genetic
T6836 11610-11634 SO:0000771 denotes quantitative trait locus
T6837 11636-11639 SO:0000771 denotes QTL
T6838 11906-11909 SO:0000771 denotes QTL
T6839 12044-12047 SO:0000771 denotes QTL
T6840 12067-12070 PR:000003266 denotes CII
T6841 12071-12079 GO:0042571 denotes antibody
T8864 12185-12188 GO:0042611 denotes MHC
T8865 12217-12221 NCBITaxon:10088 denotes mice
T8866 12267-12272 NCBITaxon:10088 denotes mouse
T8867 12298-12303 NCBITaxon:10088 denotes mouse
T8868 12316-12325 SO:0001024 denotes haplotype
T8869 12360-12365 NCBITaxon:10088 denotes mouse
T8870 12438-12442 NCBITaxon:10088 denotes mice
T8871 12521-12528 SO:0000704 denotes genetic
T8872 12538-12550 GO:0000003 denotes reproduction
T8873 12828-12840 GO:0042613 denotes MHC class II
T8874 12828-12847 PR:000001821 denotes MHC class II A beta
T8875 12848-12853 SO:0000704 denotes genes
T8876 12924-12928 NCBITaxon:10088 denotes mice
T8877 13003-13010 SO:0000704 denotes genetic
T8878 13011-13018 GO:0065007 denotes control
T8879 13083-13088 NCBITaxon:9606 denotes human
T8880 13181-13185 NCBITaxon:10088 denotes mice
T8881 13204-13216 GO:0000003 denotes reproductive
T8882 13417-13421 NCBITaxon:10088 denotes mice
T8883 13454-13458 NCBITaxon:10088 denotes mice
T8884 13510-13514 NCBITaxon:10088 denotes mice
T8885 13756-13761 SO:0000704 denotes genes
T8886 13937-13941 UBERON:0000104 denotes life
T8887 14077-14086 GO:0007565 denotes pregnancy
T8888 14155-14159 UBERON:0000104 denotes life
T8889 14225-14234 GO:0007565 denotes pregnancy
T8890 14344-14348 NCBITaxon:10088 denotes mice
T8891 14353-14359 NCBITaxon:9606 denotes humans
T8892 14401-14409 GO:0007567 denotes delivery
T8893 14620-14623 PR:000003266 denotes CII
T8894 14932-14937 PR:000001852 denotes Ctla4
T8895 14939-14944 PR:000001852 denotes CD152
T8896 14946-14950 SO:0000704 denotes gene
T8897 15259-15264 SO:0000704 denotes genes
T8898 15391-15394 PR:000003266 denotes CII
T8899 15395-15403 GO:0042571 denotes antibody
T8900 15594-15597 SO:0000771 denotes QTL
T8901 15877-15880 SO:0000771 denotes QTL
T8902 15967-15972 SO:0000704 denotes genes
T8903 16155-16158 SO:0000771 denotes QTL
T8904 16163-16175 CHEBI:37396 denotes proteoglycan
T8905 16378-16383 NCBITaxon:10088 denotes mouse
T8906 16415-16420 SO:0000704 denotes genes
T8907 16452-16457 NCBITaxon:9606 denotes human
T8908 16486-16491 NCBITaxon:9606 denotes human
T8909 16584-16591 SO:0000853 denotes homolog
T8910 16592-16595 NCBITaxon:10114 denotes rat
T8911 16617-16626 GO:0065007 denotes regulates
T8912 16775-16778 SO:0000771 denotes QTL
T8913 16809-16818 GO:0007565 denotes pregnancy
T8914 17045-17050 SO:0000704 denotes genes
T8915 17094-17098 NCBITaxon:10088 denotes mice
T8916 17137-17147 GO:0007567 denotes deliveries
T8917 17158-17162 NCBITaxon:10088 denotes mice
T8918 17169-17178 GO:0007565 denotes pregnancy
T8919 17188-17192 NCBITaxon:10088 denotes mice
T8920 17218-17229 GO:0007565 denotes pregnancies
T8921 17243-17255 UBERON:0010148 denotes vaginal plug
T8922 17291-17300 GO:0007565 denotes pregnancy
T8923 17399-17406 SO:0000704 denotes gene(s)
T10205 17566-17570 UBERON:0000104 denotes life
T10206 17745-17748 PR:000003266 denotes CII
T2693 4263-4267 NCBITaxon:10088 denotes Mice
T2694 4281-4285 NCBITaxon:10088 denotes mice
T2695 4383-4387 NCBITaxon:10088 denotes mice
T2696 4518-4522 NCBITaxon:10088 denotes mice
T2697 4583-4589 NCBITaxon:33208 denotes animal
T2698 4610-4616 NCBITaxon:33208 denotes animal
T2699 4684-4691 NCBITaxon:33208 denotes animals
T2700 4697-4700 GO:0007631 denotes fed
T2701 4726-4732 NCBITaxon:9989 denotes rodent
T2702 4733-4737 CHEBI:33290 denotes chow
T2703 4772-4776 CHEBI:33290 denotes food
T2704 4781-4785 NCBITaxon:10114 denotes rats
T3101 5193-5197 NCBITaxon:10088 denotes mice
T3102 5284-5288 NCBITaxon:10088 denotes mice
T3103 5313-5325 GO:0000003 denotes reproductive
T3104 5343-5349 NCBITaxon:33208 denotes animal
T3105 5359-5365 GO:0007618 denotes mating
T3106 5399-5403 NCBITaxon:10088 denotes mice
T3107 5420-5424 GO:0007618 denotes mate
T3108 5463-5469 GO:0007618 denotes mating
T3109 5482-5485 GO:0042611 denotes MHC
T3110 5487-5519 GO:0042611 denotes major histocompatibility complex
T3111 5536-5540 GO:0007618 denotes mate
T3112 5575-5581 GO:0007618 denotes mating
T3113 5594-5597 GO:0042611 denotes MHC
T3114 5620-5631 GO:0007565 denotes pregnancies
T3115 5662-5666 NCBITaxon:10088 denotes mice
T5398 9054-9059 UBERON:0007023 denotes adult
T5399 9067-9071 NCBITaxon:10088 denotes mice
T1772 2626-2631 SO:0000704 denotes genes
T1773 2854-2858 NCBITaxon:10088 denotes mice
T1774 2979-2986 SO:0000704 denotes genetic
T1775 3109-3115 NCBITaxon:33208 denotes animal
T1776 3130-3139 GO:0007565 denotes Pregnancy
T1777 3143-3147 NCBITaxon:10088 denotes mice
T1778 3154-3163 GO:0007565 denotes pregnancy
T1779 3257-3263 GO:0007567 denotes partum
T1780 3275-3284 GO:0007565 denotes Pregnancy
T1781 3313-3317 NCBITaxon:10088 denotes mice
T1782 3358-3366 CHEBI:50114 denotes estrogen
T1783 3389-3395 GO:0007567 denotes partum

craft-sa-dev

Id Subject Object Predicate Lexical cue
T532 0-81 sentence denotes Identification of collagen-induced arthritis loci in aged multiparous female mice
T533 15-17 IN denotes of
T534 18-26 NN denotes collagen
T535 27-34 VBN denotes induced
T536 26-27 HYPH denotes -
T537 45-49 NNS denotes loci
T538 35-44 NN denotes arthritis
T539 50-52 IN denotes in
T540 53-57 JJ denotes aged
T541 77-81 NNS denotes mice
T542 58-69 JJ denotes multiparous
T543 70-76 JJ denotes female
T544 81-82 sentence denotes
T545 92-239 sentence denotes Collagen-induced arthritis in mice is one of the most commonly used autoimmune experimental models, with many similarities to rheumatoid arthritis.
T546 92-100 NN denotes Collagen
T547 101-108 VBN denotes induced
T548 100-101 HYPH denotes -
T549 109-118 NN denotes arthritis
T550 127-129 VBZ denotes is
T551 119-121 IN denotes in
T552 122-126 NNS denotes mice
T553 130-133 CD denotes one
T554 134-136 IN denotes of
T555 137-140 DT denotes the
T556 184-190 NNS denotes models
T557 141-145 RBS denotes most
T558 146-154 RB denotes commonly
T559 155-159 VBN denotes used
T560 160-170 JJ denotes autoimmune
T561 171-183 JJ denotes experimental
T562 190-192 , denotes ,
T563 192-196 IN denotes with
T564 197-201 JJ denotes many
T565 202-214 NNS denotes similarities
T566 215-217 IN denotes to
T567 218-228 JJ denotes rheumatoid
T568 229-238 NN denotes arthritis
T569 238-239 . denotes .
T570 239-382 sentence denotes Since collagen-induced arthritis is a complex polygenic disease there is a need for identification of several major disease-controlling genes.
T571 240-245 IN denotes Since
T572 273-275 VBZ denotes is
T573 246-254 NN denotes collagen
T574 255-262 VBN denotes induced
T575 254-255 HYPH denotes -
T576 263-272 NN denotes arthritis
T577 310-312 VBZ denotes is
T578 276-277 DT denotes a
T579 296-303 NN denotes disease
T580 278-285 JJ denotes complex
T581 286-295 JJ denotes polygenic
T582 304-309 EX denotes there
T583 313-314 DT denotes a
T584 315-319 NN denotes need
T585 320-323 IN denotes for
T586 324-338 NN denotes identification
T587 339-341 IN denotes of
T588 342-349 JJ denotes several
T589 376-381 NNS denotes genes
T590 350-355 JJ denotes major
T591 356-363 NN denotes disease
T592 364-375 VBG denotes controlling
T593 363-364 HYPH denotes -
T594 381-382 . denotes .
T595 382-626 sentence denotes Because rheumatoid arthritis particularly affects aged women, we have in the present study identified new genetic regions critical for collagen-induced arthritis by studying aged female mice of a cross between NFR/N and B10.Q (H-2q haplotype).
T596 383-390 IN denotes Because
T597 425-432 VBZ denotes affects
T598 391-401 JJ denotes rheumatoid
T599 402-411 NN denotes arthritis
T600 412-424 RB denotes particularly
T601 474-484 VBN denotes identified
T602 433-437 JJ denotes aged
T603 438-443 NNS denotes women
T604 443-445 , denotes ,
T605 445-447 PRP denotes we
T606 448-452 VBP denotes have
T607 453-455 IN denotes in
T608 456-459 DT denotes the
T609 468-473 NN denotes study
T610 460-467 JJ denotes present
T611 485-488 JJ denotes new
T612 497-504 NNS denotes regions
T613 489-496 JJ denotes genetic
T614 505-513 JJ denotes critical
T615 514-517 IN denotes for
T616 518-526 NN denotes collagen
T617 527-534 VBN denotes induced
T618 526-527 HYPH denotes -
T619 535-544 NN denotes arthritis
T620 545-547 IN denotes by
T621 548-556 VBG denotes studying
T622 557-561 JJ denotes aged
T623 569-573 NNS denotes mice
T624 562-568 JJ denotes female
T625 574-576 IN denotes of
T626 577-578 DT denotes a
T627 579-584 NN denotes cross
T628 585-592 IN denotes between
T629 593-596 NN denotes NFR
T630 597-598 NN denotes N
T631 596-597 HYPH denotes /
T632 599-602 CC denotes and
T633 603-608 NN denotes B10.Q
T634 609-610 -LRB- denotes (
T635 615-624 NN denotes haplotype
T636 610-611 NN denotes H
T637 612-614 NN denotes 2q
T638 611-612 HYPH denotes -
T639 624-625 -RRB- denotes )
T640 625-626 . denotes .
T641 626-778 sentence denotes The mice in the present study had different reproductive histories, which did not significantly affect the onset, incidence or severity of the disease.
T642 627-630 DT denotes The
T643 631-635 NNS denotes mice
T644 657-660 VBD denotes had
T645 636-638 IN denotes in
T646 639-642 DT denotes the
T647 651-656 NN denotes study
T648 643-650 JJ denotes present
T649 661-670 JJ denotes different
T650 684-693 NNS denotes histories
T651 671-683 JJ denotes reproductive
T652 693-695 , denotes ,
T653 695-700 WDT denotes which
T654 723-729 VB denotes affect
T655 701-704 VBD denotes did
T656 705-708 RB denotes not
T657 709-722 RB denotes significantly
T658 730-733 DT denotes the
T659 734-739 NN denotes onset
T660 739-741 , denotes ,
T661 741-750 NN denotes incidence
T662 751-753 CC denotes or
T663 754-762 NN denotes severity
T664 763-765 IN denotes of
T665 766-769 DT denotes the
T666 770-777 NN denotes disease
T667 777-778 . denotes .
T668 778-881 sentence denotes A total of 200 female mice were used in a total genome-wide screening with 125 microsatellite markers.
T669 779-780 DT denotes A
T670 781-786 NN denotes total
T671 811-815 VBN denotes used
T672 787-789 IN denotes of
T673 790-793 CD denotes 200
T674 801-805 NNS denotes mice
T675 794-800 JJ denotes female
T676 806-810 VBD denotes were
T677 816-818 IN denotes in
T678 819-820 DT denotes a
T679 839-848 NN denotes screening
T680 821-826 JJ denotes total
T681 827-833 NN denotes genome
T682 834-838 JJ denotes wide
T683 833-834 HYPH denotes -
T684 849-853 IN denotes with
T685 854-857 CD denotes 125
T686 873-880 NNS denotes markers
T687 858-872 NN denotes microsatellite
T688 880-881 . denotes .
T689 881-1092 sentence denotes We found one new significant quantitative trait locus affecting the arthritis incidence, severity and day of onset on chromosome 11 (denoted Cia40), which colocalizes with a locus controlling pregnancy failure.
T690 882-884 PRP denotes We
T691 885-890 VBD denotes found
T692 891-894 CD denotes one
T693 930-935 NN denotes locus
T694 895-898 JJ denotes new
T695 899-910 JJ denotes significant
T696 911-923 JJ denotes quantitative
T697 924-929 NN denotes trait
T698 936-945 VBG denotes affecting
T699 946-949 DT denotes the
T700 960-969 NN denotes incidence
T701 950-959 NN denotes arthritis
T702 969-971 , denotes ,
T703 971-979 NN denotes severity
T704 980-983 CC denotes and
T705 984-987 NN denotes day
T706 988-990 IN denotes of
T707 991-996 NN denotes onset
T708 997-999 IN denotes on
T709 1000-1010 NN denotes chromosome
T710 1011-1013 CD denotes 11
T711 1014-1015 -LRB- denotes (
T712 1015-1022 VBN denotes denoted
T713 1023-1028 NN denotes Cia40
T714 1028-1029 -RRB- denotes )
T715 1029-1031 , denotes ,
T716 1031-1036 WDT denotes which
T717 1037-1048 VBZ denotes colocalizes
T718 1049-1053 IN denotes with
T719 1054-1055 DT denotes a
T720 1084-1091 NN denotes failure
T721 1056-1061 NN denotes locus
T722 1062-1073 VBG denotes controlling
T723 1074-1083 NN denotes pregnancy
T724 1091-1092 . denotes .
T725 1092-1248 sentence denotes Furthermore, a quantitative trait locus of suggestive significance associated with the incidence, severity and day of onset was identified on chromosome 1.
T726 1093-1104 RB denotes Furthermore
T727 1221-1231 VBN denotes identified
T728 1104-1106 , denotes ,
T729 1106-1107 DT denotes a
T730 1127-1132 NN denotes locus
T731 1108-1120 JJ denotes quantitative
T732 1121-1126 NN denotes trait
T733 1133-1135 IN denotes of
T734 1136-1146 JJ denotes suggestive
T735 1147-1159 NN denotes significance
T736 1160-1170 VBN denotes associated
T737 1171-1175 IN denotes with
T738 1176-1179 DT denotes the
T739 1180-1189 NN denotes incidence
T740 1189-1191 , denotes ,
T741 1191-1199 NN denotes severity
T742 1200-1203 CC denotes and
T743 1204-1207 NN denotes day
T744 1208-1210 IN denotes of
T745 1211-1216 NN denotes onset
T746 1217-1220 VBD denotes was
T747 1232-1234 IN denotes on
T748 1235-1245 NN denotes chromosome
T749 1246-1247 CD denotes 1
T750 1247-1248 . denotes .
T751 1248-1391 sentence denotes Finally, a suggestively significant quantitative trait locus associated with collagen type II antibody titers was identified on chromosome 13.
T752 1249-1256 RB denotes Finally
T753 1363-1373 VBN denotes identified
T754 1256-1258 , denotes ,
T755 1258-1259 DT denotes a
T756 1304-1309 NN denotes locus
T757 1260-1272 RB denotes suggestively
T758 1273-1284 JJ denotes significant
T759 1285-1297 JJ denotes quantitative
T760 1298-1303 NN denotes trait
T761 1310-1320 VBN denotes associated
T762 1321-1325 IN denotes with
T763 1326-1334 NN denotes collagen
T764 1352-1358 NNS denotes titers
T765 1335-1339 NN denotes type
T766 1340-1342 CD denotes II
T767 1343-1351 NN denotes antibody
T768 1359-1362 VBD denotes was
T769 1374-1376 IN denotes on
T770 1377-1387 NN denotes chromosome
T771 1388-1390 CD denotes 13
T772 1390-1391 . denotes .
T773 1391-1552 sentence denotes This study indicates that several gene loci control arthritis in aged multiparous females, and that at least one of these loci coincides with pregnancy failure.
T774 1392-1396 DT denotes This
T775 1397-1402 NN denotes study
T776 1403-1412 VBZ denotes indicates
T777 1413-1417 IN denotes that
T778 1436-1443 VBP denotes control
T779 1418-1425 JJ denotes several
T780 1431-1435 NNS denotes loci
T781 1426-1430 NN denotes gene
T782 1444-1453 NN denotes arthritis
T783 1454-1456 IN denotes in
T784 1457-1461 JJ denotes aged
T785 1474-1481 NNS denotes females
T786 1462-1473 JJ denotes multiparous
T787 1481-1483 , denotes ,
T788 1483-1486 CC denotes and
T789 1487-1491 IN denotes that
T790 1519-1528 VBZ denotes coincides
T791 1492-1494 RB denotes at
T792 1495-1500 RBS denotes least
T793 1501-1504 CD denotes one
T794 1505-1507 IN denotes of
T795 1508-1513 DT denotes these
T796 1514-1518 NNS denotes loci
T797 1529-1533 IN denotes with
T798 1534-1543 NN denotes pregnancy
T799 1544-1551 NN denotes failure
T800 1551-1552 . denotes .
T1878 1742-1743 -LRB- denotes [
T1847 1567-1570 DT denotes The
T1848 1571-1583 NNS denotes similarities
T1849 1670-1673 VBP denotes are
T1850 1584-1591 IN denotes between
T1851 1592-1602 JJ denotes rheumatoid
T1852 1603-1612 NN denotes arthritis
T1853 1613-1614 -LRB- denotes (
T1854 1614-1616 NN denotes RA
T1855 1616-1617 -RRB- denotes )
T1856 1618-1620 IN denotes in
T1857 1621-1624 NN denotes man
T1858 1625-1628 CC denotes and
T1859 1629-1637 NN denotes collagen
T1860 1638-1645 VBN denotes induced
T1861 1637-1638 HYPH denotes -
T1862 1646-1655 NN denotes arthritis
T1863 1656-1657 -LRB- denotes (
T1864 1657-1660 NN denotes CIA
T1865 1660-1661 -RRB- denotes )
T1866 1662-1664 IN denotes in
T1867 1665-1669 NNS denotes mice
T1868 1674-1678 RB denotes well
T1869 1679-1690 VBN denotes established
T1870 1690-1692 , denotes ,
T1871 1692-1700 IN denotes although
T1872 1736-1741 VBP denotes exist
T1873 1701-1712 NNS denotes differences
T1874 1713-1715 IN denotes in
T1875 1716-1719 DT denotes the
T1876 1728-1735 NN denotes pattern
T1877 1720-1727 NN denotes disease
T1879 1743-1744 CD denotes 1
T1880 1744-1745 SYM denotes -
T1881 1745-1746 CD denotes 3
T1882 1746-1747 -RRB- denotes ]
T1883 1747-1748 . denotes .
T1884 1748-1862 sentence denotes Characteristic of RA is the fact that women of reproductive age are more susceptible to the disease than men [4].
T1885 1749-1763 JJ denotes Characteristic
T1886 1770-1772 VBZ denotes is
T1887 1764-1766 IN denotes of
T1888 1767-1769 NN denotes RA
T1889 1773-1776 DT denotes the
T1890 1777-1781 NN denotes fact
T1891 1782-1786 IN denotes that
T1892 1813-1816 VBP denotes are
T1893 1787-1792 NNS denotes women
T1894 1793-1795 IN denotes of
T1895 1796-1808 JJ denotes reproductive
T1896 1809-1812 NN denotes age
T1897 1817-1821 RBR denotes more
T1898 1822-1833 JJ denotes susceptible
T1899 1834-1836 IN denotes to
T1900 1837-1840 DT denotes the
T1901 1841-1848 NN denotes disease
T1902 1849-1853 IN denotes than
T1903 1854-1857 NNS denotes men
T1904 1858-1859 -LRB- denotes [
T1905 1859-1860 CD denotes 4
T1906 1860-1861 -RRB- denotes ]
T1907 1861-1862 . denotes .
T1908 1862-2010 sentence denotes It has also been reported that 75% of female patients (23 out of 31 females) with RA exhibit clinical remission during the course of pregnancy [5].
T1909 1863-1865 PRP denotes It
T1910 1880-1888 VBN denotes reported
T1911 1866-1869 VBZ denotes has
T1912 1870-1874 RB denotes also
T1913 1875-1879 VBN denotes been
T1914 1889-1893 IN denotes that
T1915 1948-1955 VBP denotes exhibit
T1916 1894-1896 CD denotes 75
T1917 1896-1897 NN denotes %
T1918 1898-1900 IN denotes of
T1919 1901-1907 JJ denotes female
T1920 1908-1916 NNS denotes patients
T1921 1917-1918 -LRB- denotes (
T1922 1931-1938 NNS denotes females
T1923 1918-1920 CD denotes 23
T1924 1928-1930 CD denotes 31
T1925 1921-1924 IN denotes out
T1926 1925-1927 IN denotes of
T1927 1938-1939 -RRB- denotes )
T1928 1940-1944 IN denotes with
T1929 1945-1947 NN denotes RA
T1930 1956-1964 JJ denotes clinical
T1931 1965-1974 NN denotes remission
T1932 1975-1981 IN denotes during
T1933 1982-1985 DT denotes the
T1934 1986-1992 NN denotes course
T1935 1993-1995 IN denotes of
T1936 1996-2005 NN denotes pregnancy
T1937 2006-2007 -LRB- denotes [
T1938 2007-2008 CD denotes 5
T1939 2008-2009 -RRB- denotes ]
T1940 2009-2010 . denotes .
T1941 2010-2096 sentence denotes On the other hand, it has been suggested that the onset of RA is postponed by parity.
T1942 2011-2013 IN denotes On
T1943 2042-2051 VBN denotes suggested
T1944 2014-2017 DT denotes the
T1945 2024-2028 NN denotes hand
T1946 2018-2023 JJ denotes other
T1947 2028-2030 , denotes ,
T1948 2030-2032 PRP denotes it
T1949 2033-2036 VBZ denotes has
T1950 2037-2041 VBN denotes been
T1951 2052-2056 IN denotes that
T1952 2076-2085 VBN denotes postponed
T1953 2057-2060 DT denotes the
T1954 2061-2066 NN denotes onset
T1955 2067-2069 IN denotes of
T1956 2070-2072 NN denotes RA
T1957 2073-2075 VBZ denotes is
T1958 2086-2088 IN denotes by
T1959 2089-2095 NN denotes parity
T1960 2095-2096 . denotes .
T1961 2096-2218 sentence denotes The risk of onset is reduced during pregnancy, while in the first year postpartum the chance of onset is increased [6,7].
T1962 2097-2100 DT denotes The
T1963 2101-2105 NN denotes risk
T1964 2118-2125 VBN denotes reduced
T1965 2106-2108 IN denotes of
T1966 2109-2114 NN denotes onset
T1967 2115-2117 VBZ denotes is
T1968 2126-2132 IN denotes during
T1969 2133-2142 NN denotes pregnancy
T1970 2142-2144 , denotes ,
T1971 2144-2149 IN denotes while
T1972 2202-2211 VBN denotes increased
T1973 2150-2152 IN denotes in
T1974 2153-2156 DT denotes the
T1975 2163-2167 NN denotes year
T1976 2157-2162 JJ denotes first
T1977 2168-2178 RB denotes postpartum
T1978 2179-2182 DT denotes the
T1979 2183-2189 NN denotes chance
T1980 2190-2192 IN denotes of
T1981 2193-2198 NN denotes onset
T1982 2199-2201 VBZ denotes is
T1983 2212-2213 -LRB- denotes [
T1984 2215-2216 CD denotes 7
T1985 2213-2214 CD denotes 6
T1986 2214-2215 , denotes ,
T1987 2216-2217 -RRB- denotes ]
T1988 2217-2218 . denotes .
T1989 2218-2371 sentence denotes The results of a recent study of RA in women, however, indicate that pregnancy history does not increase the incidence of the disease later in life [8].
T1990 2219-2222 DT denotes The
T1991 2223-2230 NNS denotes results
T1992 2274-2282 VBP denotes indicate
T1993 2231-2233 IN denotes of
T1994 2234-2235 DT denotes a
T1995 2243-2248 NN denotes study
T1996 2236-2242 JJ denotes recent
T1997 2249-2251 IN denotes of
T1998 2252-2254 NN denotes RA
T1999 2255-2257 IN denotes in
T2000 2258-2263 NNS denotes women
T2001 2263-2265 , denotes ,
T2002 2265-2272 RB denotes however
T2003 2272-2274 , denotes ,
T2004 2283-2287 IN denotes that
T2005 2315-2323 VB denotes increase
T2006 2288-2297 NN denotes pregnancy
T2007 2298-2305 NN denotes history
T2008 2306-2310 VBZ denotes does
T2009 2311-2314 RB denotes not
T2010 2324-2327 DT denotes the
T2011 2328-2337 NN denotes incidence
T2012 2338-2340 IN denotes of
T2013 2341-2344 DT denotes the
T2014 2345-2352 NN denotes disease
T2015 2353-2358 RB denotes later
T2016 2359-2361 IN denotes in
T2017 2362-2366 NN denotes life
T2018 2367-2368 -LRB- denotes [
T2019 2368-2369 CD denotes 8
T2020 2369-2370 -RRB- denotes ]
T2021 2370-2371 . denotes .
T2022 2371-2479 sentence denotes Adequate animal models are useful tools for the identification of genes involved in complex human diseases.
T2023 2372-2380 JJ denotes Adequate
T2024 2388-2394 NNS denotes models
T2025 2381-2387 NN denotes animal
T2026 2395-2398 VBP denotes are
T2027 2399-2405 JJ denotes useful
T2028 2406-2411 NNS denotes tools
T2029 2412-2415 IN denotes for
T2030 2416-2419 DT denotes the
T2031 2420-2434 NN denotes identification
T2032 2435-2437 IN denotes of
T2033 2438-2443 NNS denotes genes
T2034 2444-2452 VBN denotes involved
T2035 2453-2455 IN denotes in
T2036 2456-2463 JJ denotes complex
T2037 2470-2478 NNS denotes diseases
T2038 2464-2469 JJ denotes human
T2039 2478-2479 . denotes .
T2040 2479-2669 sentence denotes CIA in mice shares both immunological and pathological characteristics with human RA and is one of the most used models for the identification of genes and mechanisms involved in arthritis.
T2041 2480-2483 NN denotes CIA
T2042 2492-2498 VBZ denotes shares
T2043 2484-2486 IN denotes in
T2044 2487-2491 NNS denotes mice
T2045 2499-2503 CC denotes both
T2046 2504-2517 JJ denotes immunological
T2047 2535-2550 NNS denotes characteristics
T2048 2518-2521 CC denotes and
T2049 2522-2534 JJ denotes pathological
T2050 2551-2555 IN denotes with
T2051 2556-2561 JJ denotes human
T2052 2562-2564 NN denotes RA
T2053 2565-2568 CC denotes and
T2054 2569-2571 VBZ denotes is
T2055 2572-2575 CD denotes one
T2056 2576-2578 IN denotes of
T2057 2579-2582 DT denotes the
T2058 2593-2599 NNS denotes models
T2059 2583-2587 RBS denotes most
T2060 2588-2592 VBN denotes used
T2061 2600-2603 IN denotes for
T2062 2604-2607 DT denotes the
T2063 2608-2622 NN denotes identification
T2064 2623-2625 IN denotes of
T2065 2626-2631 NNS denotes genes
T2066 2632-2635 CC denotes and
T2067 2636-2646 NNS denotes mechanisms
T2068 2647-2655 VBN denotes involved
T2069 2656-2658 IN denotes in
T2070 2659-2668 NN denotes arthritis
T2071 2668-2669 . denotes .
T2072 2669-2848 sentence denotes The incidence of CIA is sex dependent, like the incidence in RA, although different species and different variants of the disease could lead to both male and female predominance.
T2073 2670-2673 DT denotes The
T2074 2674-2683 NN denotes incidence
T2075 2691-2693 VBZ denotes is
T2076 2684-2686 IN denotes of
T2077 2687-2690 NN denotes CIA
T2078 2694-2697 NN denotes sex
T2079 2698-2707 JJ denotes dependent
T2080 2707-2709 , denotes ,
T2081 2709-2713 IN denotes like
T2082 2714-2717 DT denotes the
T2083 2718-2727 NN denotes incidence
T2084 2728-2730 IN denotes in
T2085 2731-2733 NN denotes RA
T2086 2733-2735 , denotes ,
T2087 2735-2743 IN denotes although
T2088 2806-2810 VB denotes lead
T2089 2744-2753 JJ denotes different
T2090 2754-2761 NNS denotes species
T2091 2762-2765 CC denotes and
T2092 2766-2775 JJ denotes different
T2093 2776-2784 NNS denotes variants
T2094 2785-2787 IN denotes of
T2095 2788-2791 DT denotes the
T2096 2792-2799 NN denotes disease
T2097 2800-2805 MD denotes could
T2098 2811-2813 IN denotes to
T2099 2814-2818 CC denotes both
T2100 2819-2823 JJ denotes male
T2101 2835-2847 NN denotes predominance
T2102 2824-2827 CC denotes and
T2103 2828-2834 JJ denotes female
T2104 2847-2848 . denotes .
T2105 2848-2896 sentence denotes Male mice are more often affected than females.
T2106 2849-2853 JJ denotes Male
T2107 2854-2858 NNS denotes mice
T2108 2874-2882 VBN denotes affected
T2109 2859-2862 VBP denotes are
T2110 2863-2867 RBR denotes more
T2111 2868-2873 RB denotes often
T2112 2883-2887 IN denotes than
T2113 2888-2895 NNS denotes females
T2114 2895-2896 . denotes .
T2115 2896-3027 sentence denotes Gender differences in CIA susceptibility are dependent on many factors, including genetic, hormonal and behavioral influences [9].
T2116 2897-2903 NN denotes Gender
T2117 2904-2915 NNS denotes differences
T2118 2938-2941 VBP denotes are
T2119 2916-2918 IN denotes in
T2120 2919-2922 NN denotes CIA
T2121 2923-2937 NN denotes susceptibility
T2122 2942-2951 JJ denotes dependent
T2123 2952-2954 IN denotes on
T2124 2955-2959 JJ denotes many
T2125 2960-2967 NNS denotes factors
T2126 2967-2969 , denotes ,
T2127 2969-2978 VBG denotes including
T2128 2979-2986 JJ denotes genetic
T2129 3012-3022 NNS denotes influences
T2130 2986-2988 , denotes ,
T2131 2988-2996 JJ denotes hormonal
T2132 2997-3000 CC denotes and
T2133 3001-3011 JJ denotes behavioral
T2134 3023-3024 -LRB- denotes [
T2135 3024-3025 CD denotes 9
T2136 3025-3026 -RRB- denotes ]
T2137 3026-3027 . denotes .
T2138 3027-3129 sentence denotes However, isolated factors are remarkably consistent between RA and the different animal models [3,9].
T2139 3028-3035 RB denotes However
T2140 3054-3057 VBP denotes are
T2141 3035-3037 , denotes ,
T2142 3037-3045 VBN denotes isolated
T2143 3046-3053 NNS denotes factors
T2144 3058-3068 RB denotes remarkably
T2145 3069-3079 JJ denotes consistent
T2146 3080-3087 IN denotes between
T2147 3088-3090 NN denotes RA
T2148 3091-3094 CC denotes and
T2149 3095-3098 DT denotes the
T2150 3116-3122 NNS denotes models
T2151 3099-3108 JJ denotes different
T2152 3109-3115 NN denotes animal
T2153 3123-3124 -LRB- denotes [
T2154 3126-3127 CD denotes 9
T2155 3124-3125 CD denotes 3
T2156 3125-3126 , denotes ,
T2157 3127-3128 -RRB- denotes ]
T2158 3128-3129 . denotes .
T2159 3129-3274 sentence denotes Pregnancy in mice, like pregnancy in women, normally causes remission of arthritis [5,10], while exacerbation often occurs postpartum [7,10,11].
T2160 3130-3139 NN denotes Pregnancy
T2161 3183-3189 VBZ denotes causes
T2162 3140-3142 IN denotes in
T2163 3143-3147 NNS denotes mice
T2164 3147-3149 , denotes ,
T2165 3149-3153 IN denotes like
T2166 3154-3163 NN denotes pregnancy
T2167 3164-3166 IN denotes in
T2168 3167-3172 NNS denotes women
T2169 3172-3174 , denotes ,
T2170 3174-3182 RB denotes normally
T2171 3190-3199 NN denotes remission
T2172 3200-3202 IN denotes of
T2173 3203-3212 NN denotes arthritis
T2174 3213-3214 -LRB- denotes [
T2175 3216-3218 CD denotes 10
T2176 3214-3215 CD denotes 5
T2177 3215-3216 , denotes ,
T2178 3218-3219 -RRB- denotes ]
T2179 3219-3221 , denotes ,
T2180 3221-3226 IN denotes while
T2181 3246-3252 VBZ denotes occurs
T2182 3227-3239 NN denotes exacerbation
T2183 3240-3245 RB denotes often
T2184 3253-3263 RB denotes postpartum
T2185 3264-3265 -LRB- denotes [
T2186 3270-3272 CD denotes 11
T2187 3265-3266 CD denotes 7
T2188 3266-3267 , denotes ,
T2189 3267-3269 CD denotes 10
T2190 3269-3270 , denotes ,
T2191 3272-3273 -RRB- denotes ]
T2192 3273-3274 . denotes .
T2193 3274-3520 sentence denotes Pregnancy-induced remission of CIA in mice appears to be caused by the increase in estrogen levels, while the postpartum exacerbation can be explained by the dramatic drop in estrogen [10], possibly together with increased prolactin levels [11].
T2194 3275-3284 NN denotes Pregnancy
T2195 3285-3292 VBN denotes induced
T2196 3284-3285 HYPH denotes -
T2197 3293-3302 NN denotes remission
T2198 3318-3325 VBZ denotes appears
T2199 3303-3305 IN denotes of
T2200 3306-3309 NN denotes CIA
T2201 3310-3312 IN denotes in
T2202 3313-3317 NNS denotes mice
T2203 3326-3328 TO denotes to
T2204 3332-3338 VBN denotes caused
T2205 3329-3331 VB denotes be
T2206 3339-3341 IN denotes by
T2207 3342-3345 DT denotes the
T2208 3346-3354 NN denotes increase
T2209 3355-3357 IN denotes in
T2210 3358-3366 NN denotes estrogen
T2211 3367-3373 NNS denotes levels
T2212 3373-3375 , denotes ,
T2213 3375-3380 IN denotes while
T2214 3416-3425 VBN denotes explained
T2215 3381-3384 DT denotes the
T2216 3396-3408 NN denotes exacerbation
T2217 3385-3395 NN denotes postpartum
T2218 3409-3412 MD denotes can
T2219 3413-3415 VB denotes be
T2220 3426-3428 IN denotes by
T2221 3429-3432 DT denotes the
T2222 3442-3446 NN denotes drop
T2223 3433-3441 JJ denotes dramatic
T2224 3447-3449 IN denotes in
T2225 3450-3458 NN denotes estrogen
T2226 3459-3460 -LRB- denotes [
T2227 3460-3462 CD denotes 10
T2228 3462-3463 -RRB- denotes ]
T2229 3463-3465 , denotes ,
T2230 3465-3473 RB denotes possibly
T2231 3474-3482 RB denotes together
T2232 3483-3487 IN denotes with
T2233 3488-3497 VBN denotes increased
T2234 3508-3514 NNS denotes levels
T2235 3498-3507 NN denotes prolactin
T2236 3515-3516 -LRB- denotes [
T2237 3516-3518 CD denotes 11
T2238 3518-3519 -RRB- denotes ]
T2239 3519-3520 . denotes .
T2240 3520-3661 sentence denotes To what extent the pregnancy history (parity) affects the incidence of CIA later in life has, to our knowledge, not previously been studied.
T2241 3521-3523 IN denotes To
T2242 3567-3574 VBZ denotes affects
T2243 3524-3528 WDT denotes what
T2244 3529-3535 NN denotes extent
T2245 3536-3539 DT denotes the
T2246 3550-3557 NN denotes history
T2247 3540-3549 NN denotes pregnancy
T2248 3558-3559 -LRB- denotes (
T2249 3559-3565 NN denotes parity
T2250 3565-3566 -RRB- denotes )
T2251 3653-3660 VBN denotes studied
T2252 3575-3578 DT denotes the
T2253 3579-3588 NN denotes incidence
T2254 3589-3591 IN denotes of
T2255 3592-3595 NN denotes CIA
T2256 3596-3601 RB denotes later
T2257 3602-3604 IN denotes in
T2258 3605-3609 NN denotes life
T2259 3610-3613 VBZ denotes has
T2260 3613-3615 , denotes ,
T2261 3615-3617 IN denotes to
T2262 3618-3621 PRP$ denotes our
T2263 3622-3631 NN denotes knowledge
T2264 3631-3633 , denotes ,
T2265 3633-3636 RB denotes not
T2266 3637-3647 RB denotes previously
T2267 3648-3652 VBN denotes been
T2268 3660-3661 . denotes .
T2269 3661-3831 sentence denotes Importantly, RA occurs predominantly in women, many of which have had several children, and it is therefore appropriate to also mimic this situation using animal models.
T2270 3662-3673 RB denotes Importantly
T2271 3678-3684 VBZ denotes occurs
T2272 3673-3675 , denotes ,
T2273 3675-3677 NN denotes RA
T2274 3685-3698 RB denotes predominantly
T2275 3699-3701 IN denotes in
T2276 3702-3707 NNS denotes women
T2277 3707-3709 , denotes ,
T2278 3709-3713 JJ denotes many
T2279 3728-3731 VBN denotes had
T2280 3714-3716 IN denotes of
T2281 3717-3722 WDT denotes which
T2282 3723-3727 VBP denotes have
T2283 3732-3739 JJ denotes several
T2284 3740-3748 NNS denotes children
T2285 3748-3750 , denotes ,
T2286 3750-3753 CC denotes and
T2287 3754-3756 PRP denotes it
T2288 3757-3759 VBZ denotes is
T2289 3760-3769 RB denotes therefore
T2290 3770-3781 JJ denotes appropriate
T2291 3782-3784 TO denotes to
T2292 3790-3795 VB denotes mimic
T2293 3785-3789 RB denotes also
T2294 3796-3800 DT denotes this
T2295 3801-3810 NN denotes situation
T2296 3811-3816 VBG denotes using
T2297 3817-3823 NN denotes animal
T2298 3824-3830 NNS denotes models
T2299 3830-3831 . denotes .
T2300 3831-4041 sentence denotes In the present paper we have analyzed female mice that previously had undergone a reproductive study (Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson Å, Holmdahl R, Mattsson R, unpublished data).
T2301 3832-3834 IN denotes In
T2302 3861-3869 VBN denotes analyzed
T2303 3835-3838 DT denotes the
T2304 3847-3852 NN denotes paper
T2305 3839-3846 JJ denotes present
T2306 3853-3855 PRP denotes we
T2307 3856-3860 VBP denotes have
T2308 3870-3876 JJ denotes female
T2309 3877-3881 NNS denotes mice
T2310 3882-3886 WDT denotes that
T2311 3902-3911 VBN denotes undergone
T2312 3887-3897 RB denotes previously
T2313 3898-3901 VBD denotes had
T2314 3912-3913 DT denotes a
T2315 3927-3932 NN denotes study
T2316 3914-3926 JJ denotes reproductive
T2317 3933-3934 -LRB- denotes (
T2318 3934-3943 NNP denotes Liljander
T2319 3944-3945 NNP denotes M
T2320 3945-3947 , denotes ,
T2321 3947-3956 NNP denotes Sällström
T2322 3957-3959 NNP denotes MA
T2323 3959-3961 , denotes ,
T2324 3961-3970 NNP denotes Andersson
T2325 3971-3972 NNP denotes S
T2326 3972-3974 , denotes ,
T2327 3974-3982 NNP denotes Wernhoff
T2328 3983-3984 NNP denotes P
T2329 3984-3986 , denotes ,
T2330 3986-3995 NNP denotes Andersson
T2331 3996-3997 NNP denotes Å
T2332 3997-3999 , denotes ,
T2333 3999-4007 NNP denotes Holmdahl
T2334 4008-4009 NNP denotes R
T2335 4009-4011 , denotes ,
T2336 4011-4019 NNP denotes Mattsson
T2337 4020-4021 NNP denotes R
T2338 4021-4023 , denotes ,
T2339 4023-4034 JJ denotes unpublished
T2340 4035-4039 NNS denotes data
T2341 4039-4040 -RRB- denotes )
T2342 4040-4041 . denotes .
T2343 4041-4238 sentence denotes A total of 200 female mice (ten months of age) of the N2 backcross between NFR/N and C57BL/B10.Q (B10.Q) were used to analyze the genetic control of CIA in aged females with a multiparous history.
T2344 4042-4043 DT denotes A
T2345 4044-4049 NN denotes total
T2346 4152-4156 VBN denotes used
T2347 4050-4052 IN denotes of
T2348 4053-4056 CD denotes 200
T2349 4064-4068 NNS denotes mice
T2350 4057-4063 JJ denotes female
T2351 4069-4070 -LRB- denotes (
T2352 4074-4080 NNS denotes months
T2353 4070-4073 CD denotes ten
T2354 4081-4083 IN denotes of
T2355 4084-4087 NN denotes age
T2356 4087-4088 -RRB- denotes )
T2357 4089-4091 IN denotes of
T2358 4092-4095 DT denotes the
T2359 4099-4108 NN denotes backcross
T2360 4096-4098 NN denotes N2
T2361 4109-4116 IN denotes between
T2362 4117-4120 NN denotes NFR
T2363 4121-4122 NN denotes N
T2364 4120-4121 HYPH denotes /
T2365 4123-4126 CC denotes and
T2366 4127-4132 NN denotes C57BL
T2367 4133-4138 NN denotes B10.Q
T2368 4132-4133 HYPH denotes /
T2369 4139-4140 -LRB- denotes (
T2370 4140-4145 NN denotes B10.Q
T2371 4145-4146 -RRB- denotes )
T2372 4147-4151 VBD denotes were
T2373 4157-4159 TO denotes to
T2374 4160-4167 VB denotes analyze
T2375 4168-4171 DT denotes the
T2376 4180-4187 NN denotes control
T2377 4172-4179 JJ denotes genetic
T2378 4188-4190 IN denotes of
T2379 4191-4194 NN denotes CIA
T2380 4195-4197 IN denotes in
T2381 4198-4202 JJ denotes aged
T2382 4203-4210 NNS denotes females
T2383 4211-4215 IN denotes with
T2384 4216-4217 DT denotes a
T2385 4230-4237 NN denotes history
T2386 4218-4229 JJ denotes multiparous
T2387 4237-4238 . denotes .
T2732 4263-4267 NNS denotes Mice
T2733 4267-4461 sentence denotes Inbred NFR/N mice were originally obtained from the National Institute of Health (Bethesda, MD, USA) and the B10.Q mice were originally bought from The Jackson Laboratory (Bar Harbor, ME, USA).
T2734 4268-4274 VBN denotes Inbred
T2735 4281-4285 NNS denotes mice
T2736 4275-4278 NN denotes NFR
T2737 4279-4280 NN denotes N
T2738 4278-4279 HYPH denotes /
T2739 4302-4310 VBN denotes obtained
T2740 4286-4290 VBD denotes were
T2741 4291-4301 RB denotes originally
T2742 4311-4315 IN denotes from
T2743 4316-4319 DT denotes the
T2744 4329-4338 NNP denotes Institute
T2745 4320-4328 NNP denotes National
T2746 4339-4341 IN denotes of
T2747 4342-4348 NNP denotes Health
T2748 4349-4350 -LRB- denotes (
T2749 4350-4358 NNP denotes Bethesda
T2750 4358-4360 , denotes ,
T2751 4360-4362 NNP denotes MD
T2752 4362-4364 , denotes ,
T2753 4364-4367 NNP denotes USA
T2754 4367-4368 -RRB- denotes )
T2755 4369-4372 CC denotes and
T2756 4373-4376 DT denotes the
T2757 4383-4387 NNS denotes mice
T2758 4377-4382 NN denotes B10.Q
T2759 4404-4410 VBN denotes bought
T2760 4388-4392 VBD denotes were
T2761 4393-4403 RB denotes originally
T2762 4411-4415 IN denotes from
T2763 4416-4419 DT denotes The
T2764 4428-4438 NNP denotes Laboratory
T2765 4420-4427 NNP denotes Jackson
T2766 4439-4440 -LRB- denotes (
T2767 4444-4450 NNP denotes Harbor
T2768 4440-4443 NNP denotes Bar
T2769 4450-4452 , denotes ,
T2770 4452-4454 NNP denotes ME
T2771 4454-4456 , denotes ,
T2772 4456-4459 NNP denotes USA
T2773 4459-4460 -RRB- denotes )
T2774 4460-4461 . denotes .
T2775 4461-4679 sentence denotes (B10Q × NFR/N)F1 hybrids and (B10.Q × NFR/N) × B10.Q N2 mice were bred in individual ventilated cages in the BMC Barrier animal facility and at the animal house of the Department of Pathology, Lund University, Sweden.
T2776 4462-4463 -LRB- denotes (
T2777 4479-4486 NNS denotes hybrids
T2778 4463-4467 NN denotes B10Q
T2779 4476-4478 NN denotes F1
T2780 4468-4469 HYPH denotes ×
T2781 4470-4473 NN denotes NFR
T2782 4474-4475 NN denotes N
T2783 4473-4474 HYPH denotes /
T2784 4475-4476 -RRB- denotes )
T2785 4528-4532 VBN denotes bred
T2786 4487-4490 CC denotes and
T2787 4491-4492 -LRB- denotes (
T2788 4518-4522 NNS denotes mice
T2789 4492-4497 NN denotes B10.Q
T2790 4498-4499 SYM denotes ×
T2791 4500-4503 NN denotes NFR
T2792 4504-4505 NN denotes N
T2793 4503-4504 HYPH denotes /
T2794 4505-4506 -RRB- denotes )
T2795 4507-4508 SYM denotes ×
T2796 4509-4514 NN denotes B10.Q
T2797 4515-4517 NN denotes N2
T2798 4523-4527 VBD denotes were
T2799 4533-4535 IN denotes in
T2800 4536-4546 JJ denotes individual
T2801 4558-4563 NNS denotes cages
T2802 4547-4557 VBN denotes ventilated
T2803 4564-4566 IN denotes in
T2804 4567-4570 DT denotes the
T2805 4590-4598 NN denotes facility
T2806 4571-4574 NN denotes BMC
T2807 4575-4582 NN denotes Barrier
T2808 4583-4589 NN denotes animal
T2809 4599-4602 CC denotes and
T2810 4603-4605 IN denotes at
T2811 4606-4609 DT denotes the
T2812 4617-4622 NN denotes house
T2813 4610-4616 NN denotes animal
T2814 4623-4625 IN denotes of
T2815 4626-4629 DT denotes the
T2816 4630-4640 NNP denotes Department
T2817 4641-4643 IN denotes of
T2818 4644-4653 NNP denotes Pathology
T2819 4653-4655 , denotes ,
T2820 4655-4659 NNP denotes Lund
T2821 4660-4670 NNP denotes University
T2822 4670-4672 , denotes ,
T2823 4672-4678 NNP denotes Sweden
T2824 4678-4679 . denotes .
T2825 4679-4887 sentence denotes The animals were fed ad libitum with standard rodent chow (LAB FOR R36, irradiated breeding food for rats and mice; Lactamin AB, Stockholm, Sweden) and water in a photoperiod of 12 hours:12 hours light:dark.
T2826 4680-4683 DT denotes The
T2827 4684-4691 NNS denotes animals
T2828 4697-4700 VBN denotes fed
T2829 4692-4696 VBD denotes were
T2830 4701-4703 FW denotes ad
T2831 4704-4711 FW denotes libitum
T2832 4712-4716 IN denotes with
T2833 4717-4725 JJ denotes standard
T2834 4733-4737 NN denotes chow
T2835 4726-4732 NN denotes rodent
T2836 4738-4739 -LRB- denotes (
T2837 4805-4807 NNP denotes AB
T2838 4739-4742 NN denotes LAB
T2839 4747-4750 NN denotes R36
T2840 4743-4746 NN denotes FOR
T2841 4750-4752 , denotes ,
T2842 4752-4762 VBN denotes irradiated
T2843 4772-4776 NN denotes food
T2844 4763-4771 VBG denotes breeding
T2845 4777-4780 IN denotes for
T2846 4781-4785 NNS denotes rats
T2847 4786-4789 CC denotes and
T2848 4790-4794 NNS denotes mice
T2849 4794-4795 : denotes ;
T2850 4796-4804 NNP denotes Lactamin
T2851 4807-4809 , denotes ,
T2852 4809-4818 NNP denotes Stockholm
T2853 4818-4820 , denotes ,
T2854 4820-4826 NNP denotes Sweden
T2855 4826-4827 -RRB- denotes )
T2856 4828-4831 CC denotes and
T2857 4832-4837 NN denotes water
T2858 4838-4840 IN denotes in
T2859 4841-4842 DT denotes a
T2860 4843-4854 NN denotes photoperiod
T2861 4855-4857 IN denotes of
T2862 4858-4860 CD denotes 12
T2863 4861-4866 NNS denotes hours
T2864 4866-4867 SYM denotes :
T2865 4870-4875 NNS denotes hours
T2866 4867-4869 CD denotes 12
T2867 4876-4881 NN denotes light
T2868 4881-4882 SYM denotes :
T2869 4882-4886 NN denotes dark
T2870 4886-4887 . denotes .
T2871 4887-5056 sentence denotes The mice used in the present study had clean health monitoring protocols according to the Federation of European Laboratory Animal Sciences Association recommendations.
T2872 4888-4891 DT denotes The
T2873 4892-4896 NNS denotes mice
T2874 4923-4926 VBD denotes had
T2875 4897-4901 VBN denotes used
T2876 4902-4904 IN denotes in
T2877 4905-4908 DT denotes the
T2878 4917-4922 NN denotes study
T2879 4909-4916 JJ denotes present
T2880 4927-4932 JJ denotes clean
T2881 4951-4960 NNS denotes protocols
T2882 4933-4939 NN denotes health
T2883 4940-4950 NN denotes monitoring
T2884 4961-4970 VBG denotes according
T2885 4971-4973 IN denotes to
T2886 4974-4977 DT denotes the
T2887 4978-4988 NNP denotes Federation
T2888 5028-5039 NNP denotes Association
T2889 4989-4991 IN denotes of
T2890 4992-5000 NNP denotes European
T2891 5019-5027 NNPS denotes Sciences
T2892 5001-5011 NNP denotes Laboratory
T2893 5012-5018 NNP denotes Animal
T2894 5040-5055 NNS denotes recommendations
T2895 5055-5056 . denotes .
T2896 5056-5149 sentence denotes Ethical permissions were M125-04 (embryo transfer) and M290-03 (reproduction and arthritis).
T2897 5057-5064 JJ denotes Ethical
T2898 5065-5076 NNS denotes permissions
T2899 5077-5081 VBD denotes were
T2900 5082-5086 NN denotes M125
T2901 5086-5087 HYPH denotes -
T2902 5087-5089 CD denotes 04
T2903 5090-5091 -LRB- denotes (
T2904 5098-5106 NN denotes transfer
T2905 5091-5097 NN denotes embryo
T2906 5106-5107 -RRB- denotes )
T2907 5108-5111 CC denotes and
T2908 5112-5116 NN denotes M290
T2909 5116-5117 HYPH denotes -
T2910 5117-5119 CD denotes 03
T2911 5120-5121 -LRB- denotes (
T2912 5121-5133 NN denotes reproduction
T2913 5134-5137 CC denotes and
T2914 5138-5147 NN denotes arthritis
T2915 5147-5148 -RRB- denotes )
T2916 5148-5149 . denotes .
T3136 5151-5163 JJ denotes Experimental
T3137 5164-5170 NN denotes design
T3138 5170-5279 sentence denotes A total of 200 female mice (approximately ten months old) of N2 backcross (B10.Q × NFR/N) × B10.Q were used.
T3139 5171-5172 DT denotes A
T3140 5173-5178 NN denotes total
T3141 5274-5278 VBN denotes used
T3142 5179-5181 IN denotes of
T3143 5182-5185 CD denotes 200
T3144 5193-5197 NNS denotes mice
T3145 5186-5192 JJ denotes female
T3146 5198-5199 -LRB- denotes (
T3147 5199-5212 RB denotes approximately
T3148 5213-5216 CD denotes ten
T3149 5217-5223 NNS denotes months
T3150 5224-5227 JJ denotes old
T3151 5227-5228 -RRB- denotes )
T3152 5229-5231 IN denotes of
T3153 5232-5234 NN denotes N2
T3154 5235-5244 NN denotes backcross
T3155 5245-5246 -LRB- denotes (
T3156 5246-5251 NN denotes B10.Q
T3157 5252-5253 HYPH denotes ×
T3158 5254-5257 NN denotes NFR
T3159 5258-5259 NN denotes N
T3160 5257-5258 HYPH denotes /
T3161 5259-5260 -RRB- denotes )
T3162 5261-5262 HYPH denotes ×
T3163 5263-5268 NN denotes B10.Q
T3164 5269-5273 VBD denotes were
T3165 5278-5279 . denotes .
T3166 5279-5380 sentence denotes The mice had earlier undergone a reproductive study where each animal had four mating opportunities.
T3167 5280-5283 DT denotes The
T3168 5284-5288 NNS denotes mice
T3169 5289-5292 VBD denotes had
T3170 5293-5300 RBR denotes earlier
T3171 5301-5310 VBN denotes undergone
T3172 5311-5312 DT denotes a
T3173 5326-5331 NN denotes study
T3174 5313-5325 JJ denotes reproductive
T3175 5332-5337 WRB denotes where
T3176 5350-5353 VBD denotes had
T3177 5338-5342 DT denotes each
T3178 5343-5349 NN denotes animal
T3179 5354-5358 CD denotes four
T3180 5366-5379 NNS denotes opportunities
T3181 5359-5365 NN denotes mating
T3182 5379-5380 . denotes .
T3183 5380-5599 sentence denotes First, the female mice were allowed to mate twice with B10.RIII males (allogeneic mating by means of MHC (major histocompatibility complex) and finally to mate twice with B10.Q males (syngeneic mating by means of MHC).
T3184 5381-5386 RB denotes First
T3185 5409-5416 VBN denotes allowed
T3186 5386-5388 , denotes ,
T3187 5388-5391 DT denotes the
T3188 5399-5403 NNS denotes mice
T3189 5392-5398 JJ denotes female
T3190 5404-5408 VBD denotes were
T3191 5417-5419 TO denotes to
T3192 5420-5424 VB denotes mate
T3193 5425-5430 RB denotes twice
T3194 5431-5435 IN denotes with
T3195 5436-5444 NN denotes B10.RIII
T3196 5445-5450 NNS denotes males
T3197 5451-5452 -LRB- denotes (
T3198 5463-5469 NN denotes mating
T3199 5452-5462 JJ denotes allogeneic
T3200 5470-5472 IN denotes by
T3201 5473-5478 NNS denotes means
T3202 5479-5481 IN denotes of
T3203 5482-5485 NN denotes MHC
T3204 5486-5487 -LRB- denotes (
T3205 5487-5492 JJ denotes major
T3206 5512-5519 NN denotes complex
T3207 5493-5511 NN denotes histocompatibility
T3208 5519-5520 -RRB- denotes )
T3209 5521-5524 CC denotes and
T3210 5525-5532 RB denotes finally
T3211 5536-5540 VB denotes mate
T3212 5533-5535 TO denotes to
T3213 5541-5546 RB denotes twice
T3214 5547-5551 IN denotes with
T3215 5552-5557 NN denotes B10.Q
T3216 5558-5563 NNS denotes males
T3217 5564-5565 -LRB- denotes (
T3218 5575-5581 NN denotes mating
T3219 5565-5574 JJ denotes syngeneic
T3220 5582-5584 IN denotes by
T3221 5585-5590 NNS denotes means
T3222 5591-5593 IN denotes of
T3223 5594-5597 NN denotes MHC
T3224 5597-5598 -RRB- denotes )
T3225 5598-5599 . denotes .
T3226 5599-5667 sentence denotes After four possible pregnancies CIA was induced to the female mice.
T3227 5600-5605 IN denotes After
T3228 5640-5647 VBN denotes induced
T3229 5606-5610 CD denotes four
T3230 5620-5631 NNS denotes pregnancies
T3231 5611-5619 JJ denotes possible
T3232 5632-5635 NN denotes CIA
T3233 5636-5639 VBD denotes was
T3234 5648-5650 IN denotes to
T3235 5651-5654 DT denotes the
T3236 5662-5666 NNS denotes mice
T3237 5655-5661 JJ denotes female
T3238 5666-5667 . denotes .
T3705 5669-5678 NN denotes Induction
T3706 5679-5682 CC denotes and
T3707 5683-5693 NN denotes evaluation
T3708 5694-5696 IN denotes of
T3709 5697-5700 NN denotes CIA
T3710 5700-5948 sentence denotes To induce CIA, the mice were immunized subcutaneously at the base of the tail with 100 μg rat collagen type II (CII) emulsified in 0.1 M acetic acid combined with an equal amount of complete Freud's adjuvant (Difco Laboratories, Detroit, MI, USA).
T3711 5701-5703 TO denotes To
T3712 5704-5710 VB denotes induce
T3713 5730-5739 VBN denotes immunized
T3714 5711-5714 NN denotes CIA
T3715 5714-5716 , denotes ,
T3716 5716-5719 DT denotes the
T3717 5720-5724 NNS denotes mice
T3718 5725-5729 VBD denotes were
T3719 5740-5754 RB denotes subcutaneously
T3720 5755-5757 IN denotes at
T3721 5758-5761 DT denotes the
T3722 5762-5766 NN denotes base
T3723 5767-5769 IN denotes of
T3724 5770-5773 DT denotes the
T3725 5774-5778 NN denotes tail
T3726 5779-5783 IN denotes with
T3727 5784-5787 CD denotes 100
T3728 5788-5790 NN denotes μg
T3729 5804-5808 NN denotes type
T3730 5791-5794 NN denotes rat
T3731 5795-5803 NN denotes collagen
T3732 5809-5811 CD denotes II
T3733 5812-5813 -LRB- denotes (
T3734 5813-5816 NN denotes CII
T3735 5816-5817 -RRB- denotes )
T3736 5818-5828 VBN denotes emulsified
T3737 5829-5831 IN denotes in
T3738 5832-5835 CD denotes 0.1
T3739 5836-5837 NN denotes M
T3740 5845-5849 NN denotes acid
T3741 5838-5844 JJ denotes acetic
T3742 5850-5858 VBN denotes combined
T3743 5859-5863 IN denotes with
T3744 5864-5866 DT denotes an
T3745 5873-5879 NN denotes amount
T3746 5867-5872 JJ denotes equal
T3747 5880-5882 IN denotes of
T3748 5883-5891 JJ denotes complete
T3749 5900-5908 NN denotes adjuvant
T3750 5892-5897 NNP denotes Freud
T3751 5897-5899 POS denotes 's
T3752 5909-5910 -LRB- denotes (
T3753 5916-5928 NNP denotes Laboratories
T3754 5910-5915 NNP denotes Difco
T3755 5928-5930 , denotes ,
T3756 5930-5937 NNP denotes Detroit
T3757 5937-5939 , denotes ,
T3758 5939-5941 NNP denotes MI
T3759 5941-5943 , denotes ,
T3760 5943-5946 NNP denotes USA
T3761 5946-5947 -RRB- denotes )
T3762 5947-5948 . denotes .
T3763 5948-6128 sentence denotes A booster injection containing 50 μg CII emulsified in 0.1 M acetic acid combined with an equal amount of Freud's incomplete adjuvant (Difco Laboratories) was given after 30 days.
T3764 5949-5950 DT denotes A
T3765 5959-5968 NN denotes injection
T3766 5951-5958 NN denotes booster
T3767 6108-6113 VBN denotes given
T3768 5969-5979 VBG denotes containing
T3769 5980-5982 CD denotes 50
T3770 5983-5985 NN denotes μg
T3771 5986-5989 NN denotes CII
T3772 5990-6000 VBN denotes emulsified
T3773 6001-6003 IN denotes in
T3774 6004-6007 CD denotes 0.1
T3775 6008-6009 NN denotes M
T3776 6017-6021 NN denotes acid
T3777 6010-6016 JJ denotes acetic
T3778 6022-6030 VBN denotes combined
T3779 6031-6035 IN denotes with
T3780 6036-6038 DT denotes an
T3781 6045-6051 NN denotes amount
T3782 6039-6044 JJ denotes equal
T3783 6052-6054 IN denotes of
T3784 6055-6060 NNP denotes Freud
T3785 6074-6082 NN denotes adjuvant
T3786 6060-6062 POS denotes 's
T3787 6063-6073 JJ denotes incomplete
T3788 6083-6084 -LRB- denotes (
T3789 6090-6102 NNP denotes Laboratories
T3790 6084-6089 NNP denotes Difco
T3791 6102-6103 -RRB- denotes )
T3792 6104-6107 VBD denotes was
T3793 6114-6119 IN denotes after
T3794 6120-6122 CD denotes 30
T3795 6123-6127 NNS denotes days
T3796 6127-6128 . denotes .
T3797 6128-6210 sentence denotes The clinical scoring of arthritis commenced 25 days after the first immunization.
T3798 6129-6132 DT denotes The
T3799 6142-6149 NN denotes scoring
T3800 6133-6141 JJ denotes clinical
T3801 6163-6172 VBD denotes commenced
T3802 6150-6152 IN denotes of
T3803 6153-6162 NN denotes arthritis
T3804 6173-6175 CD denotes 25
T3805 6176-6180 NNS denotes days
T3806 6181-6186 IN denotes after
T3807 6187-6190 DT denotes the
T3808 6197-6209 NN denotes immunization
T3809 6191-6196 JJ denotes first
T3810 6209-6210 . denotes .
T3811 6210-6316 sentence denotes Animals were examined for clinical signs of CIA three times per week and were graded on a 12-point scale.
T3812 6211-6218 NNS denotes Animals
T3813 6224-6232 VBN denotes examined
T3814 6219-6223 VBD denotes were
T3815 6233-6236 IN denotes for
T3816 6237-6245 JJ denotes clinical
T3817 6246-6251 NNS denotes signs
T3818 6252-6254 IN denotes of
T3819 6255-6258 NN denotes CIA
T3820 6259-6264 CD denotes three
T3821 6265-6270 NNS denotes times
T3822 6271-6274 IN denotes per
T3823 6275-6279 NN denotes week
T3824 6280-6283 CC denotes and
T3825 6284-6288 VBD denotes were
T3826 6289-6295 VBN denotes graded
T3827 6296-6298 IN denotes on
T3828 6299-6300 DT denotes a
T3829 6310-6315 NN denotes scale
T3830 6301-6303 CD denotes 12
T3831 6304-6309 NN denotes point
T3832 6303-6304 HYPH denotes -
T3833 6315-6316 . denotes .
T3834 6316-6572 sentence denotes The arthritis index was assigned to each mouse using the following criteria: 0 = no visible sign of arthritis, 1 = redness and swelling in a single joint, 2 = inflammation in multiple joints, and 3 = severe inflammation in the entire paw and/or anklebone.
T3835 6317-6320 DT denotes The
T3836 6331-6336 NN denotes index
T3837 6321-6330 NN denotes arthritis
T3838 6341-6349 VBN denotes assigned
T3839 6337-6340 VBD denotes was
T3840 6409-6413 NN denotes sign
T3841 6350-6352 IN denotes to
T3842 6353-6357 DT denotes each
T3843 6358-6363 NN denotes mouse
T3844 6364-6369 VBG denotes using
T3845 6370-6373 DT denotes the
T3846 6384-6392 NNS denotes criteria
T3847 6374-6383 VBG denotes following
T3848 6392-6394 : denotes :
T3849 6394-6395 CD denotes 0
T3850 6396-6397 SYM denotes =
T3851 6398-6400 DT denotes no
T3852 6401-6408 JJ denotes visible
T3853 6414-6416 IN denotes of
T3854 6417-6426 NN denotes arthritis
T3855 6426-6428 , denotes ,
T3856 6428-6429 CD denotes 1
T3857 6432-6439 NN denotes redness
T3858 6430-6431 SYM denotes =
T3859 6440-6443 CC denotes and
T3860 6444-6452 NN denotes swelling
T3861 6453-6455 IN denotes in
T3862 6456-6457 DT denotes a
T3863 6465-6470 NN denotes joint
T3864 6458-6464 JJ denotes single
T3865 6470-6472 , denotes ,
T3866 6472-6473 CD denotes 2
T3867 6476-6488 NN denotes inflammation
T3868 6474-6475 SYM denotes =
T3869 6489-6491 IN denotes in
T3870 6492-6500 JJ denotes multiple
T3871 6501-6507 NNS denotes joints
T3872 6507-6509 , denotes ,
T3873 6509-6512 CC denotes and
T3874 6513-6514 CD denotes 3
T3875 6524-6536 NN denotes inflammation
T3876 6515-6516 SYM denotes =
T3877 6517-6523 JJ denotes severe
T3878 6537-6539 IN denotes in
T3879 6540-6543 DT denotes the
T3880 6551-6554 NN denotes paw
T3881 6544-6550 JJ denotes entire
T3882 6555-6558 CC denotes and
T3883 6558-6559 HYPH denotes /
T3884 6559-6561 CC denotes or
T3885 6562-6571 NN denotes anklebone
T3886 6571-6572 . denotes .
T3887 6572-6654 sentence denotes Each paw was given the scores 0–3, with the index being the sum of all four paws.
T3888 6573-6577 DT denotes Each
T3889 6578-6581 NN denotes paw
T3890 6586-6591 VBN denotes given
T3891 6582-6585 VBD denotes was
T3892 6592-6595 DT denotes the
T3893 6596-6602 NNS denotes scores
T3894 6603-6604 CD denotes 0
T3895 6604-6605 SYM denotes –
T3896 6605-6606 CD denotes 3
T3897 6606-6608 , denotes ,
T3898 6608-6612 IN denotes with
T3899 6613-6616 DT denotes the
T3900 6617-6622 NN denotes index
T3901 6623-6628 VBG denotes being
T3902 6629-6632 DT denotes the
T3903 6633-6636 NN denotes sum
T3904 6637-6639 IN denotes of
T3905 6640-6643 DT denotes all
T3906 6649-6653 NNS denotes paws
T3907 6644-6648 CD denotes four
T3908 6653-6654 . denotes .
T3909 6654-6730 sentence denotes The severity trait is the maximum score observed in each individual female.
T3910 6655-6658 DT denotes The
T3911 6668-6673 NN denotes trait
T3912 6659-6667 NN denotes severity
T3913 6674-6676 VBZ denotes is
T3914 6677-6680 DT denotes the
T3915 6689-6694 NN denotes score
T3916 6681-6688 JJ denotes maximum
T3917 6695-6703 VBN denotes observed
T3918 6704-6706 IN denotes in
T3919 6707-6711 DT denotes each
T3920 6723-6729 NN denotes female
T3921 6712-6722 JJ denotes individual
T3922 6729-6730 . denotes .
T3923 6730-6872 sentence denotes The onset is the number of days calculated from the first immunization to the first clinical signs of arthritis excluding unaffected animals.
T3924 6731-6734 DT denotes The
T3925 6735-6740 NN denotes onset
T3926 6741-6743 VBZ denotes is
T3927 6744-6747 DT denotes the
T3928 6748-6754 NN denotes number
T3929 6755-6757 IN denotes of
T3930 6758-6762 NNS denotes days
T3931 6763-6773 VBN denotes calculated
T3932 6774-6778 IN denotes from
T3933 6779-6782 DT denotes the
T3934 6789-6801 NN denotes immunization
T3935 6783-6788 JJ denotes first
T3936 6802-6804 IN denotes to
T3937 6805-6808 DT denotes the
T3938 6824-6829 NNS denotes signs
T3939 6809-6814 JJ denotes first
T3940 6815-6823 JJ denotes clinical
T3941 6830-6832 IN denotes of
T3942 6833-6842 NN denotes arthritis
T3943 6843-6852 VBG denotes excluding
T3944 6853-6863 JJ denotes unaffected
T3945 6864-6871 NNS denotes animals
T3946 6871-6872 . denotes .
T4742 6874-6888 NN denotes Microsatellite
T4743 6889-6899 NN denotes genotyping
T4744 6900-6903 CC denotes and
T4745 6904-6911 NN denotes linkage
T4746 6912-6920 NN denotes analysis
T4747 6920-6992 sentence denotes Tail biopsies were collected from all N2 females and the F0 generation.
T4748 6921-6925 NN denotes Tail
T4749 6926-6934 NNS denotes biopsies
T4750 6940-6949 VBN denotes collected
T4751 6935-6939 VBD denotes were
T4752 6950-6954 IN denotes from
T4753 6955-6958 DT denotes all
T4754 6962-6969 NNS denotes females
T4755 6959-6961 NN denotes N2
T4756 6970-6973 CC denotes and
T4757 6974-6977 DT denotes the
T4758 6981-6991 NN denotes generation
T4759 6978-6980 NN denotes F0
T4760 6991-6992 . denotes .
T4761 6992-7060 sentence denotes DNA was isolated according to a previously described protocol [12].
T4762 6993-6996 NN denotes DNA
T4763 7001-7009 VBN denotes isolated
T4764 6997-7000 VBD denotes was
T4765 7010-7019 VBG denotes according
T4766 7020-7022 IN denotes to
T4767 7023-7024 DT denotes a
T4768 7046-7054 NN denotes protocol
T4769 7025-7035 RB denotes previously
T4770 7036-7045 VBN denotes described
T4771 7055-7056 -LRB- denotes [
T4772 7056-7058 CD denotes 12
T4773 7058-7059 -RRB- denotes ]
T4774 7059-7060 . denotes .
T4775 7060-7253 sentence denotes After screening of parental DNA with approximately 450 mouse fluorescence-labeled microsatellite markers (INTERACTIVA, Ulm, Germany), 125 informative markers were selected covering the genome.
T4776 7061-7066 IN denotes After
T4777 7233-7241 VBG denotes covering
T4778 7067-7076 NN denotes screening
T4779 7077-7079 IN denotes of
T4780 7080-7088 JJ denotes parental
T4781 7089-7092 NN denotes DNA
T4782 7093-7097 IN denotes with
T4783 7098-7111 RB denotes approximately
T4784 7112-7115 CD denotes 450
T4785 7158-7165 NNS denotes markers
T4786 7116-7121 NN denotes mouse
T4787 7122-7134 NN denotes fluorescence
T4788 7135-7142 VBN denotes labeled
T4789 7134-7135 HYPH denotes -
T4790 7143-7157 NN denotes microsatellite
T4791 7166-7167 -LRB- denotes (
T4792 7167-7178 NNP denotes INTERACTIVA
T4793 7178-7180 , denotes ,
T4794 7180-7183 NNP denotes Ulm
T4795 7183-7185 , denotes ,
T4796 7185-7192 NNP denotes Germany
T4797 7192-7193 -RRB- denotes )
T4798 7193-7195 , denotes ,
T4799 7195-7198 CD denotes 125
T4800 7211-7218 NNS denotes markers
T4801 7199-7210 JJ denotes informative
T4802 7219-7223 VBD denotes were
T4803 7224-7232 VBN denotes selected
T4804 7242-7245 DT denotes the
T4805 7246-7252 NN denotes genome
T4806 7252-7253 . denotes .
T4807 7253-7372 sentence denotes Two hundred and thirty-seven N2 mice were genotyped with markers covering all chromosomes except for the Y chromosome.
T4808 7254-7257 CD denotes Two
T4809 7258-7265 CD denotes hundred
T4810 7286-7290 NNS denotes mice
T4811 7266-7269 CC denotes and
T4812 7270-7276 CD denotes thirty
T4813 7277-7282 CD denotes seven
T4814 7276-7277 HYPH denotes -
T4815 7283-7285 NN denotes N2
T4816 7296-7305 VBN denotes genotyped
T4817 7291-7295 VBD denotes were
T4818 7306-7310 IN denotes with
T4819 7311-7318 NNS denotes markers
T4820 7319-7327 VBG denotes covering
T4821 7328-7331 DT denotes all
T4822 7332-7343 NNS denotes chromosomes
T4823 7344-7350 IN denotes except
T4824 7351-7354 IN denotes for
T4825 7355-7358 DT denotes the
T4826 7361-7371 NN denotes chromosome
T4827 7359-7360 NN denotes Y
T4828 7371-7372 . denotes .
T4829 7372-7774 sentence denotes PCR amplification for the markers was performed in a final volume of 10 μl in a 96-well V-bottom microtiter plate using 20 ng DNA, 10 mM KCl, 20 mM Tris–HCl, 10 mM (NH4)2SO4, 2 mM MgCl2, 0.1% Triton X-100, pH 8.8 (New England BioLabs Inc., Ipswich, MA, USA), 3 μM (10 pmol) each primer, 2 mM dNTPs (Advanced Biotechnologies, Epsom, Surrey, UK) and 0.25 U Taq DNA Polymerase (New England BioLabs Inc.).
T4830 7373-7376 NN denotes PCR
T4831 7377-7390 NN denotes amplification
T4832 7411-7420 VBN denotes performed
T4833 7391-7394 IN denotes for
T4834 7395-7398 DT denotes the
T4835 7399-7406 NNS denotes markers
T4836 7407-7410 VBD denotes was
T4837 7421-7423 IN denotes in
T4838 7424-7425 DT denotes a
T4839 7432-7438 NN denotes volume
T4840 7426-7431 JJ denotes final
T4841 7439-7441 IN denotes of
T4842 7442-7444 CD denotes 10
T4843 7445-7447 NN denotes μl
T4844 7448-7450 IN denotes in
T4845 7451-7452 DT denotes a
T4846 7481-7486 NN denotes plate
T4847 7453-7455 CD denotes 96
T4848 7456-7460 NN denotes well
T4849 7455-7456 HYPH denotes -
T4850 7461-7462 NN denotes V
T4851 7463-7469 NN denotes bottom
T4852 7462-7463 HYPH denotes -
T4853 7470-7480 NN denotes microtiter
T4854 7487-7492 VBG denotes using
T4855 7493-7495 CD denotes 20
T4856 7496-7498 NN denotes ng
T4857 7499-7502 NN denotes DNA
T4858 7502-7504 , denotes ,
T4859 7504-7506 CD denotes 10
T4860 7507-7509 NN denotes mM
T4861 7510-7513 NN denotes KCl
T4862 7513-7515 , denotes ,
T4863 7515-7517 CD denotes 20
T4864 7518-7520 NN denotes mM
T4865 7526-7529 NN denotes HCl
T4866 7521-7525 NN denotes Tris
T4867 7525-7526 HYPH denotes –
T4868 7529-7531 , denotes ,
T4869 7531-7533 CD denotes 10
T4870 7534-7536 NN denotes mM
T4871 7542-7546 NN denotes 2SO4
T4872 7537-7538 -LRB- denotes (
T4873 7538-7541 NN denotes NH4
T4874 7541-7542 -RRB- denotes )
T4875 7546-7548 , denotes ,
T4876 7548-7549 CD denotes 2
T4877 7550-7552 NN denotes mM
T4878 7553-7558 NN denotes MgCl2
T4879 7558-7560 , denotes ,
T4880 7560-7563 CD denotes 0.1
T4881 7563-7564 NN denotes %
T4882 7572-7573 NN denotes X
T4883 7565-7571 NN denotes Triton
T4884 7573-7574 HYPH denotes -
T4885 7574-7577 CD denotes 100
T4886 7577-7579 , denotes ,
T4887 7579-7581 NN denotes pH
T4888 7582-7585 CD denotes 8.8
T4889 7586-7587 -LRB- denotes (
T4890 7607-7611 NNP denotes Inc.
T4891 7587-7590 NNP denotes New
T4892 7591-7598 NNP denotes England
T4893 7599-7606 NNP denotes BioLabs
T4894 7611-7613 , denotes ,
T4895 7613-7620 NNP denotes Ipswich
T4896 7620-7622 , denotes ,
T4897 7622-7624 NNP denotes MA
T4898 7624-7626 , denotes ,
T4899 7626-7629 NNP denotes USA
T4900 7629-7630 -RRB- denotes )
T4901 7630-7632 , denotes ,
T4902 7632-7633 CD denotes 3
T4903 7634-7636 NN denotes μM
T4904 7652-7658 NN denotes primer
T4905 7637-7638 -LRB- denotes (
T4906 7641-7645 NN denotes pmol
T4907 7638-7640 CD denotes 10
T4908 7645-7646 -RRB- denotes )
T4909 7647-7651 DT denotes each
T4910 7658-7660 , denotes ,
T4911 7660-7661 CD denotes 2
T4912 7662-7664 NN denotes mM
T4913 7665-7670 NNS denotes dNTPs
T4914 7671-7672 -LRB- denotes (
T4915 7681-7696 NNP denotes Biotechnologies
T4916 7672-7680 NNP denotes Advanced
T4917 7696-7698 , denotes ,
T4918 7698-7703 NNP denotes Epsom
T4919 7703-7705 , denotes ,
T4920 7705-7711 NNP denotes Surrey
T4921 7711-7713 , denotes ,
T4922 7713-7715 NNP denotes UK
T4923 7715-7716 -RRB- denotes )
T4924 7717-7720 CC denotes and
T4925 7721-7725 CD denotes 0.25
T4926 7726-7727 NN denotes U
T4927 7736-7746 NN denotes Polymerase
T4928 7728-7731 NN denotes Taq
T4929 7732-7735 NN denotes DNA
T4930 7747-7748 -LRB- denotes (
T4931 7768-7772 NNP denotes Inc.
T4932 7748-7751 NNP denotes New
T4933 7752-7759 NNP denotes England
T4934 7760-7767 NNP denotes BioLabs
T4935 7772-7773 -RRB- denotes )
T4936 7773-7774 . denotes .
T4937 7774-8058 sentence denotes The following program was used to amplify the DNA: denaturation at 95°C for 3 minutes, annealing at 56°C for 45 seconds, polymerization at 72°C for 1 minute, 30 cycles of 95°C for 30 seconds, 56°C for 45 seconds and 72°C for 1 minute, and a final extension step of 7 minutes at 72°C.
T4938 7775-7778 DT denotes The
T4939 7789-7796 NN denotes program
T4940 7779-7788 VBG denotes following
T4941 7801-7805 VBN denotes used
T4942 7797-7800 VBD denotes was
T4943 7806-7808 TO denotes to
T4944 7809-7816 VB denotes amplify
T4945 7817-7820 DT denotes the
T4946 7821-7824 NN denotes DNA
T4947 7824-7826 : denotes :
T4948 7826-7838 NN denotes denaturation
T4949 7839-7841 IN denotes at
T4950 7842-7844 CD denotes 95
T4951 7844-7846 NN denotes °C
T4952 7847-7850 IN denotes for
T4953 7851-7852 CD denotes 3
T4954 7853-7860 NNS denotes minutes
T4955 7860-7862 , denotes ,
T4956 7862-7871 VBG denotes annealing
T4957 7872-7874 IN denotes at
T4958 7875-7877 CD denotes 56
T4959 7877-7879 NN denotes °C
T4960 7880-7883 IN denotes for
T4961 7884-7886 CD denotes 45
T4962 7887-7894 NNS denotes seconds
T4963 7894-7896 , denotes ,
T4964 7896-7910 NN denotes polymerization
T4965 7911-7913 IN denotes at
T4966 7914-7916 CD denotes 72
T4967 7916-7918 NN denotes °C
T4968 7919-7922 IN denotes for
T4969 7923-7924 CD denotes 1
T4970 7925-7931 NN denotes minute
T4971 7931-7933 , denotes ,
T4972 7933-7935 CD denotes 30
T4973 7936-7942 NNS denotes cycles
T4974 7943-7945 IN denotes of
T4975 7946-7948 CD denotes 95
T4976 7948-7950 NN denotes °C
T4977 7951-7954 IN denotes for
T4978 7955-7957 CD denotes 30
T4979 7958-7965 NNS denotes seconds
T4980 7965-7967 , denotes ,
T4981 7967-7969 CD denotes 56
T4982 7969-7971 NN denotes °C
T4983 7972-7975 IN denotes for
T4984 7976-7978 CD denotes 45
T4985 7979-7986 NNS denotes seconds
T4986 7987-7990 CC denotes and
T4987 7991-7993 CD denotes 72
T4988 7993-7995 NN denotes °C
T4989 7996-7999 IN denotes for
T4990 8000-8001 CD denotes 1
T4991 8002-8008 NN denotes minute
T4992 8008-8010 , denotes ,
T4993 8010-8013 CC denotes and
T4994 8014-8015 DT denotes a
T4995 8032-8036 NN denotes step
T4996 8016-8021 JJ denotes final
T4997 8022-8031 NN denotes extension
T4998 8037-8039 IN denotes of
T4999 8040-8041 CD denotes 7
T5000 8042-8049 NNS denotes minutes
T5001 8050-8052 IN denotes at
T5002 8053-8055 CD denotes 72
T5003 8055-8057 NN denotes °C
T5004 8057-8058 . denotes .
T5005 8058-8204 sentence denotes The PCR products were analyzed on a MegaBACE™ 1000 (Amersham Pharmacia Biotech Inc Piscataway, NJ, USA) according to the manufacturer's protocol.
T5006 8059-8062 DT denotes The
T5007 8067-8075 NNS denotes products
T5008 8063-8066 NN denotes PCR
T5009 8081-8089 VBN denotes analyzed
T5010 8076-8080 VBD denotes were
T5011 8090-8092 IN denotes on
T5012 8093-8094 DT denotes a
T5013 8095-8103 NNP denotes MegaBACE
T5014 8103-8104 SYM denotes ™
T5015 8105-8109 CD denotes 1000
T5016 8110-8111 -LRB- denotes (
T5017 8138-8141 NNP denotes Inc
T5018 8111-8119 NNP denotes Amersham
T5019 8120-8129 NNP denotes Pharmacia
T5020 8130-8137 NNP denotes Biotech
T5021 8142-8152 NNP denotes Piscataway
T5022 8152-8154 , denotes ,
T5023 8154-8156 NNP denotes NJ
T5024 8156-8158 , denotes ,
T5025 8158-8161 NNP denotes USA
T5026 8161-8162 -RRB- denotes )
T5027 8163-8172 VBG denotes according
T5028 8173-8175 IN denotes to
T5029 8176-8179 DT denotes the
T5030 8180-8192 NN denotes manufacturer
T5031 8195-8203 NN denotes protocol
T5032 8192-8194 POS denotes 's
T5033 8203-8204 . denotes .
T5034 8204-8283 sentence denotes Data were analyzed with Genetic Profiler 1.1 (Amersham Pharmacia Biotech Inc).
T5035 8205-8209 NNS denotes Data
T5036 8215-8223 VBN denotes analyzed
T5037 8210-8214 VBD denotes were
T5038 8224-8228 IN denotes with
T5039 8229-8236 JJ denotes Genetic
T5040 8237-8245 NN denotes Profiler
T5041 8246-8249 CD denotes 1.1
T5042 8250-8251 -LRB- denotes (
T5043 8278-8281 NNP denotes Inc
T5044 8251-8259 NNP denotes Amersham
T5045 8260-8269 NNP denotes Pharmacia
T5046 8270-8277 NNP denotes Biotech
T5047 8281-8282 -RRB- denotes )
T5048 8282-8283 . denotes .
T5049 8283-8384 sentence denotes Map Manager QTXb20 free software [13] was used to perform linkage analysis and the permutation test.
T5050 8284-8287 NNP denotes Map
T5051 8296-8302 NNP denotes QTXb20
T5052 8288-8295 NNP denotes Manager
T5053 8308-8316 NN denotes software
T5054 8303-8307 JJ denotes free
T5055 8326-8330 VBN denotes used
T5056 8317-8318 -LRB- denotes [
T5057 8318-8320 CD denotes 13
T5058 8320-8321 -RRB- denotes ]
T5059 8322-8325 VBD denotes was
T5060 8331-8333 TO denotes to
T5061 8334-8341 VB denotes perform
T5062 8342-8349 NN denotes linkage
T5063 8350-8358 NN denotes analysis
T5064 8359-8362 CC denotes and
T5065 8363-8366 DT denotes the
T5066 8379-8383 NN denotes test
T5067 8367-8378 NN denotes permutation
T5068 8383-8384 . denotes .
T5069 8384-8460 sentence denotes Ninety percent of the mouse genome was within a 20 cM intermarker distance.
T5070 8385-8391 CD denotes Ninety
T5071 8392-8399 NN denotes percent
T5072 8420-8423 VBD denotes was
T5073 8400-8402 IN denotes of
T5074 8403-8406 DT denotes the
T5075 8413-8419 NN denotes genome
T5076 8407-8412 NN denotes mouse
T5077 8424-8430 IN denotes within
T5078 8431-8432 DT denotes a
T5079 8451-8459 NN denotes distance
T5080 8433-8435 CD denotes 20
T5081 8436-8438 NN denotes cM
T5082 8439-8450 NN denotes intermarker
T5083 8459-8460 . denotes .
T5084 8460-8591 sentence denotes The marker map was generated using the Kosambis map function and 1,000 permutations were performed for every phenotype (P < 0.05).
T5085 8461-8464 DT denotes The
T5086 8472-8475 NN denotes map
T5087 8465-8471 NN denotes marker
T5088 8480-8489 VBN denotes generated
T5089 8476-8479 VBD denotes was
T5090 8490-8495 VBG denotes using
T5091 8496-8499 DT denotes the
T5092 8513-8521 NN denotes function
T5093 8500-8508 NNP denotes Kosambis
T5094 8509-8512 NN denotes map
T5095 8522-8525 CC denotes and
T5096 8526-8531 CD denotes 1,000
T5097 8532-8544 NNS denotes permutations
T5098 8550-8559 VBN denotes performed
T5099 8545-8549 VBD denotes were
T5100 8560-8563 IN denotes for
T5101 8564-8569 DT denotes every
T5102 8570-8579 NN denotes phenotype
T5103 8580-8581 -LRB- denotes (
T5104 8585-8589 CD denotes 0.05
T5105 8581-8582 NN denotes P
T5106 8583-8584 SYM denotes <
T5107 8589-8590 -RRB- denotes )
T5108 8590-8591 . denotes .
T5109 8591-8699 sentence denotes The permutation tests were carried out to establish empirical significance thresholds for the interactions.
T5110 8592-8595 DT denotes The
T5111 8608-8613 NNS denotes tests
T5112 8596-8607 NN denotes permutation
T5113 8619-8626 VBN denotes carried
T5114 8614-8618 VBD denotes were
T5115 8627-8630 RP denotes out
T5116 8631-8633 TO denotes to
T5117 8634-8643 VB denotes establish
T5118 8644-8653 JJ denotes empirical
T5119 8654-8666 NN denotes significance
T5120 8667-8677 NNS denotes thresholds
T5121 8678-8681 IN denotes for
T5122 8682-8685 DT denotes the
T5123 8686-8698 NNS denotes interactions
T5124 8698-8699 . denotes .
T5125 8699-8888 sentence denotes A threshold equal to or above the 37th percentile (P = 0.63) was considered suggestively significant, and the level for the significant threshold was set to the 95th percentile (P = 0.05).
T5126 8700-8701 DT denotes A
T5127 8702-8711 NN denotes threshold
T5128 8765-8775 VBN denotes considered
T5129 8712-8717 JJ denotes equal
T5130 8718-8720 IN denotes to
T5131 8721-8723 CC denotes or
T5132 8724-8729 IN denotes above
T5133 8739-8749 NN denotes percentile
T5134 8730-8733 DT denotes the
T5135 8734-8738 JJ denotes 37th
T5136 8750-8751 -LRB- denotes (
T5137 8755-8759 CD denotes 0.63
T5138 8751-8752 NN denotes P
T5139 8753-8754 SYM denotes =
T5140 8759-8760 -RRB- denotes )
T5141 8761-8764 VBD denotes was
T5142 8776-8788 RB denotes suggestively
T5143 8789-8800 JJ denotes significant
T5144 8800-8802 , denotes ,
T5145 8802-8805 CC denotes and
T5146 8806-8809 DT denotes the
T5147 8810-8815 NN denotes level
T5148 8850-8853 VBN denotes set
T5149 8816-8819 IN denotes for
T5150 8820-8823 DT denotes the
T5151 8836-8845 NN denotes threshold
T5152 8824-8835 JJ denotes significant
T5153 8846-8849 VBD denotes was
T5154 8854-8856 IN denotes to
T5155 8857-8860 DT denotes the
T5156 8866-8876 NN denotes percentile
T5157 8861-8865 JJ denotes 95th
T5158 8877-8878 -LRB- denotes (
T5159 8882-8886 CD denotes 0.05
T5160 8878-8879 NN denotes P
T5161 8880-8881 SYM denotes =
T5162 8886-8887 -RRB- denotes )
T5163 8887-8888 . denotes .
T5164 8888-9014 sentence denotes Interval mapping was made with a 2 cM increase under the additive regression model in order to calculate the test statistics.
T5165 8889-8897 JJ denotes Interval
T5166 8898-8905 NN denotes mapping
T5167 8910-8914 VBN denotes made
T5168 8906-8909 VBD denotes was
T5169 8915-8919 IN denotes with
T5170 8920-8921 DT denotes a
T5171 8927-8935 NN denotes increase
T5172 8922-8923 CD denotes 2
T5173 8924-8926 NN denotes cM
T5174 8936-8941 IN denotes under
T5175 8942-8945 DT denotes the
T5176 8966-8971 NN denotes model
T5177 8946-8954 JJ denotes additive
T5178 8955-8965 NN denotes regression
T5179 8972-8974 IN denotes in
T5180 8975-8980 NN denotes order
T5181 8981-8983 TO denotes to
T5182 8984-8993 VB denotes calculate
T5183 8994-8997 DT denotes the
T5184 9003-9013 NNS denotes statistics
T5185 8998-9002 NN denotes test
T5186 9013-9014 . denotes .
T5443 9016-9022 NN denotes Enzyme
T5444 9023-9029 VBN denotes linked
T5445 9022-9023 HYPH denotes -
T5446 9044-9049 NN denotes assay
T5447 9030-9043 NN denotes immunosorbent
T5448 9049-9132 sentence denotes The adult female mice were sacrificed at 15 months of age and sera were collected.
T5449 9050-9053 DT denotes The
T5450 9067-9071 NNS denotes mice
T5451 9054-9059 JJ denotes adult
T5452 9060-9066 JJ denotes female
T5453 9077-9087 VBN denotes sacrificed
T5454 9072-9076 VBD denotes were
T5455 9088-9090 IN denotes at
T5456 9091-9093 CD denotes 15
T5457 9094-9100 NNS denotes months
T5458 9101-9103 IN denotes of
T5459 9104-9107 NN denotes age
T5460 9108-9111 CC denotes and
T5461 9112-9116 NNS denotes sera
T5462 9122-9131 VBN denotes collected
T5463 9117-9121 VBD denotes were
T5464 9131-9132 . denotes .
T5465 9132-9215 sentence denotes Anti-CII antibody titers in sera were analyzed by a sandwich ELISA technique [14].
T5466 9133-9141 JJ denotes Anti-CII
T5467 9151-9157 NNS denotes titers
T5468 9142-9150 NN denotes antibody
T5469 9171-9179 VBN denotes analyzed
T5470 9158-9160 IN denotes in
T5471 9161-9165 NNS denotes sera
T5472 9166-9170 VBD denotes were
T5473 9180-9182 IN denotes by
T5474 9183-9184 DT denotes a
T5475 9200-9209 NN denotes technique
T5476 9185-9193 NN denotes sandwich
T5477 9194-9199 NN denotes ELISA
T5478 9210-9211 -LRB- denotes [
T5479 9211-9213 CD denotes 14
T5480 9213-9214 -RRB- denotes ]
T5481 9214-9215 . denotes .
T5482 9215-9294 sentence denotes In brief, CII (10 μg/ml) was coupled to immunosorbent plates overnight at 4°C.
T5483 9216-9218 IN denotes In
T5484 9245-9252 VBN denotes coupled
T5485 9219-9224 JJ denotes brief
T5486 9224-9226 , denotes ,
T5487 9226-9229 NN denotes CII
T5488 9230-9231 -LRB- denotes (
T5489 9234-9236 NN denotes μg
T5490 9231-9233 CD denotes 10
T5491 9236-9237 SYM denotes /
T5492 9237-9239 NN denotes ml
T5493 9239-9240 -RRB- denotes )
T5494 9241-9244 VBD denotes was
T5495 9253-9255 IN denotes to
T5496 9256-9269 NN denotes immunosorbent
T5497 9270-9276 NNS denotes plates
T5498 9277-9286 RB denotes overnight
T5499 9287-9289 IN denotes at
T5500 9290-9291 CD denotes 4
T5501 9291-9293 NN denotes °C
T5502 9293-9294 . denotes .
T5503 9294-9520 sentence denotes Bovine serum albumin (Sigma Chemical St Louis, MO, USA) was used for blocking, and thereafter different dilutions of control sera (purified mouse anti-CII antibodies), test sera, and positive and negative controls were added.
T5504 9295-9301 JJ denotes Bovine
T5505 9308-9315 NN denotes albumin
T5506 9302-9307 NN denotes serum
T5507 9355-9359 VBN denotes used
T5508 9316-9317 -LRB- denotes (
T5509 9323-9331 NNP denotes Chemical
T5510 9317-9322 NNP denotes Sigma
T5511 9332-9334 NNP denotes St
T5512 9335-9340 NNP denotes Louis
T5513 9340-9342 , denotes ,
T5514 9342-9344 NNP denotes MO
T5515 9344-9346 , denotes ,
T5516 9346-9349 NNP denotes USA
T5517 9349-9350 -RRB- denotes )
T5518 9351-9354 VBD denotes was
T5519 9360-9363 IN denotes for
T5520 9364-9372 NN denotes blocking
T5521 9372-9374 , denotes ,
T5522 9374-9377 CC denotes and
T5523 9378-9388 RB denotes thereafter
T5524 9514-9519 VBN denotes added
T5525 9389-9398 JJ denotes different
T5526 9399-9408 NNS denotes dilutions
T5527 9409-9411 IN denotes of
T5528 9412-9419 NN denotes control
T5529 9420-9424 NNS denotes sera
T5530 9425-9426 -LRB- denotes (
T5531 9450-9460 NNS denotes antibodies
T5532 9426-9434 VBN denotes purified
T5533 9435-9440 NN denotes mouse
T5534 9441-9449 JJ denotes anti-CII
T5535 9460-9461 -RRB- denotes )
T5536 9461-9463 , denotes ,
T5537 9463-9467 NN denotes test
T5538 9468-9472 NNS denotes sera
T5539 9472-9474 , denotes ,
T5540 9474-9477 CC denotes and
T5541 9478-9486 JJ denotes positive
T5542 9500-9508 NNS denotes controls
T5543 9487-9490 CC denotes and
T5544 9491-9499 JJ denotes negative
T5545 9509-9513 VBD denotes were
T5546 9519-9520 . denotes .
T5547 9520-9622 sentence denotes The presence of CII-specific IgG was visualized by means of peroxidase-conjugated goat antimouse IgG.
T5548 9521-9524 DT denotes The
T5549 9525-9533 NN denotes presence
T5550 9558-9568 VBN denotes visualized
T5551 9534-9536 IN denotes of
T5552 9537-9540 NN denotes CII
T5553 9541-9549 JJ denotes specific
T5554 9540-9541 HYPH denotes -
T5555 9550-9553 NN denotes IgG
T5556 9554-9557 VBD denotes was
T5557 9569-9571 IN denotes by
T5558 9572-9577 NNS denotes means
T5559 9578-9580 IN denotes of
T5560 9581-9591 NN denotes peroxidase
T5561 9592-9602 VBN denotes conjugated
T5562 9591-9592 HYPH denotes -
T5563 9618-9621 NN denotes IgG
T5564 9603-9607 NN denotes goat
T5565 9608-9617 JJ denotes antimouse
T5566 9621-9622 . denotes .
T5629 9754-9756 CC denotes or
T5630 9757-9764 NNP denotes Student
T5631 9778-9782 NN denotes test
T5632 9764-9766 POS denotes 's
T5633 9767-9775 JJ denotes unpaired
T5634 9776-9777 NN denotes t
T5635 9782-9783 . denotes .
T5888 9794-9797 NN denotes NFR
T5889 9798-9799 NN denotes N
T5890 9797-9798 HYPH denotes /
T5891 9807-9811 NNS denotes mice
T5892 9800-9806 JJ denotes female
T5893 9812-9816 VBP denotes show
T5894 9817-9824 VBN denotes delayed
T5895 9825-9830 NN denotes onset
T5896 9831-9834 CC denotes and
T5897 9835-9840 JJR denotes lower
T5898 9841-9850 NN denotes incidence
T5899 9851-9853 IN denotes of
T5900 9854-9857 NN denotes CIA
T5901 9858-9866 VBN denotes compared
T5902 9867-9871 IN denotes with
T5903 9872-9877 NN denotes B10.Q
T5904 9878-9885 NNS denotes females
T5905 9885-10045 sentence denotes The onset of the disease was significantly delayed in NFR/N mice, which resulted in lower incidence in the initial phase of the disease (Table 1 and Figure 1).
T5906 9886-9889 DT denotes The
T5907 9890-9895 NN denotes onset
T5908 9929-9936 VBN denotes delayed
T5909 9896-9898 IN denotes of
T5910 9899-9902 DT denotes the
T5911 9903-9910 NN denotes disease
T5912 9911-9914 VBD denotes was
T5913 9915-9928 RB denotes significantly
T5914 9937-9939 IN denotes in
T5915 9940-9943 NN denotes NFR
T5916 9944-9945 NN denotes N
T5917 9943-9944 HYPH denotes /
T5918 9946-9950 NNS denotes mice
T5919 9950-9952 , denotes ,
T5920 9952-9957 WDT denotes which
T5921 9958-9966 VBD denotes resulted
T5922 9967-9969 IN denotes in
T5923 9970-9975 JJR denotes lower
T5924 9976-9985 NN denotes incidence
T5925 9986-9988 IN denotes in
T5926 9989-9992 DT denotes the
T5927 10001-10006 NN denotes phase
T5928 9993-10000 JJ denotes initial
T5929 10007-10009 IN denotes of
T5930 10010-10013 DT denotes the
T5931 10014-10021 NN denotes disease
T5932 10022-10023 -LRB- denotes (
T5933 10023-10028 NN denotes Table
T5934 10029-10030 CD denotes 1
T5935 10031-10034 CC denotes and
T5936 10035-10041 NN denotes Figure
T5937 10042-10043 CD denotes 1
T5938 10043-10044 -RRB- denotes )
T5939 10044-10045 . denotes .
T5940 10045-10210 sentence denotes The appearance of the arthritis was slightly different between the two strains, NFR/N mice showing a higher frequency of swelling of the entire paw than B10.Q mice.
T5941 10046-10049 DT denotes The
T5942 10050-10060 NN denotes appearance
T5943 10078-10081 VBD denotes was
T5944 10061-10063 IN denotes of
T5945 10064-10067 DT denotes the
T5946 10068-10077 NN denotes arthritis
T5947 10082-10090 RB denotes slightly
T5948 10091-10100 JJ denotes different
T5949 10101-10108 IN denotes between
T5950 10109-10112 DT denotes the
T5951 10117-10124 NNS denotes strains
T5952 10113-10116 CD denotes two
T5953 10124-10126 , denotes ,
T5954 10126-10129 NN denotes NFR
T5955 10130-10131 NN denotes N
T5956 10129-10130 HYPH denotes /
T5957 10132-10136 NNS denotes mice
T5958 10137-10144 VBG denotes showing
T5959 10145-10146 DT denotes a
T5960 10154-10163 NN denotes frequency
T5961 10147-10153 JJR denotes higher
T5962 10164-10166 IN denotes of
T5963 10167-10175 NN denotes swelling
T5964 10176-10178 IN denotes of
T5965 10179-10182 DT denotes the
T5966 10190-10193 NN denotes paw
T5967 10183-10189 JJ denotes entire
T5968 10194-10198 IN denotes than
T5969 10199-10204 NN denotes B10.Q
T5970 10205-10209 NNS denotes mice
T5971 10209-10210 . denotes .
T5972 10210-10323 sentence denotes Later in the disease course the differences in CIA frequency and severity between the strains were less obvious.
T5973 10211-10216 RBR denotes Later
T5974 10305-10309 VBD denotes were
T5975 10217-10219 IN denotes in
T5976 10220-10223 DT denotes the
T5977 10232-10238 NN denotes course
T5978 10224-10231 NN denotes disease
T5979 10239-10242 DT denotes the
T5980 10243-10254 NNS denotes differences
T5981 10255-10257 IN denotes in
T5982 10258-10261 NN denotes CIA
T5983 10262-10271 NN denotes frequency
T5984 10272-10275 CC denotes and
T5985 10276-10284 NN denotes severity
T5986 10285-10292 IN denotes between
T5987 10293-10296 DT denotes the
T5988 10297-10304 NNS denotes strains
T5989 10310-10314 RBR denotes less
T5990 10315-10322 JJ denotes obvious
T5991 10322-10323 . denotes .
T5992 10323-10494 sentence denotes However, the anti-CII titers 100 days after primary immunization (and 70 days after the booster) differed significantly between NFR/N and B10.Q female mice (see Table 1).
T5993 10324-10331 RB denotes However
T5994 10421-10429 VBD denotes differed
T5995 10331-10333 , denotes ,
T5996 10333-10336 DT denotes the
T5997 10346-10352 NNS denotes titers
T5998 10337-10345 JJ denotes anti-CII
T5999 10353-10356 CD denotes 100
T6000 10357-10361 NNS denotes days
T6001 10362-10367 IN denotes after
T6002 10368-10375 JJ denotes primary
T6003 10376-10388 NN denotes immunization
T6004 10389-10390 -LRB- denotes (
T6005 10390-10393 CC denotes and
T6006 10394-10396 CD denotes 70
T6007 10397-10401 NNS denotes days
T6008 10402-10407 IN denotes after
T6009 10408-10411 DT denotes the
T6010 10412-10419 NN denotes booster
T6011 10419-10420 -RRB- denotes )
T6012 10430-10443 RB denotes significantly
T6013 10444-10451 IN denotes between
T6014 10452-10455 NN denotes NFR
T6015 10456-10457 NN denotes N
T6016 10455-10456 HYPH denotes /
T6017 10475-10479 NNS denotes mice
T6018 10458-10461 CC denotes and
T6019 10462-10467 NN denotes B10.Q
T6020 10468-10474 JJ denotes female
T6021 10480-10481 -LRB- denotes (
T6022 10481-10484 VB denotes see
T6023 10485-10490 NN denotes Table
T6024 10491-10492 CD denotes 1
T6025 10492-10493 -RRB- denotes )
T6026 10493-10494 . denotes .
T6416 10496-10505 NN denotes Pregnancy
T6417 10506-10513 NN denotes history
T6418 10537-10543 VB denotes affect
T6419 10514-10518 VBZ denotes does
T6420 10519-10522 RB denotes not
T6421 10523-10536 RB denotes significantly
T6422 10544-10553 NN denotes incidence
T6423 10554-10556 CC denotes or
T6424 10557-10565 NN denotes severity
T6425 10566-10568 IN denotes of
T6426 10569-10572 NN denotes CIA
T6427 10573-10575 IN denotes in
T6428 10576-10582 JJ denotes female
T6429 10583-10587 NNS denotes mice
T6430 10588-10590 IN denotes of
T6431 10591-10596 JJ denotes mixed
T6432 10605-10615 NN denotes background
T6433 10597-10604 JJ denotes genetic
T6434 10615-10879 sentence denotes Table 2 presents the results of arthritic incidence, arthritis onset and maximum arthritic score for the female mice of the N2 generation, (NFR/N × B10.Q) × B10.Q, grouped according to the number of pregnancies they had experienced prior to immunization with CII.
T6435 10616-10621 NN denotes Table
T6436 10624-10632 VBZ denotes presents
T6437 10622-10623 CD denotes 2
T6438 10633-10636 DT denotes the
T6439 10637-10644 NNS denotes results
T6440 10645-10647 IN denotes of
T6441 10648-10657 JJ denotes arthritic
T6442 10658-10667 NN denotes incidence
T6443 10667-10669 , denotes ,
T6444 10669-10678 NN denotes arthritis
T6445 10679-10684 NN denotes onset
T6446 10685-10688 CC denotes and
T6447 10689-10696 JJ denotes maximum
T6448 10707-10712 NN denotes score
T6449 10697-10706 JJ denotes arthritic
T6450 10713-10716 IN denotes for
T6451 10717-10720 DT denotes the
T6452 10728-10732 NNS denotes mice
T6453 10721-10727 JJ denotes female
T6454 10733-10735 IN denotes of
T6455 10736-10739 DT denotes the
T6456 10743-10753 NN denotes generation
T6457 10740-10742 NN denotes N2
T6458 10753-10755 , denotes ,
T6459 10755-10756 -LRB- denotes (
T6460 10760-10761 NN denotes N
T6461 10756-10759 NN denotes NFR
T6462 10759-10760 HYPH denotes /
T6463 10762-10763 HYPH denotes ×
T6464 10764-10769 NN denotes B10.Q
T6465 10769-10770 -RRB- denotes )
T6466 10771-10772 HYPH denotes ×
T6467 10773-10778 NN denotes B10.Q
T6468 10778-10780 , denotes ,
T6469 10780-10787 VBN denotes grouped
T6470 10788-10797 VBG denotes according
T6471 10798-10800 IN denotes to
T6472 10801-10804 DT denotes the
T6473 10805-10811 NN denotes number
T6474 10812-10814 IN denotes of
T6475 10815-10826 NNS denotes pregnancies
T6476 10827-10831 PRP denotes they
T6477 10836-10847 VBN denotes experienced
T6478 10832-10835 VBD denotes had
T6479 10848-10853 JJ denotes prior
T6480 10854-10856 IN denotes to
T6481 10857-10869 NN denotes immunization
T6482 10870-10874 IN denotes with
T6483 10875-10878 NN denotes CII
T6484 10878-10879 . denotes .
T6485 10879-11056 sentence denotes There was no significant difference in the incidence or severity of arthritis depending on the number of pregnancies that had been passed prior to the induction of the disease.
T6486 10880-10885 EX denotes There
T6487 10886-10889 VBD denotes was
T6488 10890-10892 DT denotes no
T6489 10905-10915 NN denotes difference
T6490 10893-10904 JJ denotes significant
T6491 10916-10918 IN denotes in
T6492 10919-10922 DT denotes the
T6493 10923-10932 NN denotes incidence
T6494 10933-10935 CC denotes or
T6495 10936-10944 NN denotes severity
T6496 10945-10947 IN denotes of
T6497 10948-10957 NN denotes arthritis
T6498 10958-10967 VBG denotes depending
T6499 10968-10970 IN denotes on
T6500 10971-10974 DT denotes the
T6501 10975-10981 NN denotes number
T6502 10982-10984 IN denotes of
T6503 10985-10996 NNS denotes pregnancies
T6504 10997-11001 WDT denotes that
T6505 11011-11017 VBN denotes passed
T6506 11002-11005 VBD denotes had
T6507 11006-11010 VBN denotes been
T6508 11018-11023 JJ denotes prior
T6509 11024-11026 IN denotes to
T6510 11027-11030 DT denotes the
T6511 11031-11040 NN denotes induction
T6512 11041-11043 IN denotes of
T6513 11044-11047 DT denotes the
T6514 11048-11055 NN denotes disease
T6515 11055-11056 . denotes .
T6516 11056-11181 sentence denotes We observed a trend towards lower severity in multiparous mice compared with mice with a history of zero to two pregnancies.
T6517 11057-11059 PRP denotes We
T6518 11060-11068 VBD denotes observed
T6519 11069-11070 DT denotes a
T6520 11071-11076 NN denotes trend
T6521 11077-11084 IN denotes towards
T6522 11085-11090 JJR denotes lower
T6523 11091-11099 NN denotes severity
T6524 11100-11102 IN denotes in
T6525 11103-11114 JJ denotes multiparous
T6526 11115-11119 NNS denotes mice
T6527 11120-11128 VBN denotes compared
T6528 11129-11133 IN denotes with
T6529 11134-11138 NNS denotes mice
T6530 11139-11143 IN denotes with
T6531 11144-11145 DT denotes a
T6532 11146-11153 NN denotes history
T6533 11154-11156 IN denotes of
T6534 11157-11161 CD denotes zero
T6535 11165-11168 CD denotes two
T6536 11162-11164 IN denotes to
T6537 11169-11180 NNS denotes pregnancies
T6538 11180-11181 . denotes .
T6539 11181-11274 sentence denotes The onset of diseases, however, was earlier in mice that had passed more than one pregnancy.
T6540 11182-11185 DT denotes The
T6541 11186-11191 NN denotes onset
T6542 11214-11217 VBD denotes was
T6543 11192-11194 IN denotes of
T6544 11195-11203 NNS denotes diseases
T6545 11203-11205 , denotes ,
T6546 11205-11212 RB denotes however
T6547 11212-11214 , denotes ,
T6548 11218-11225 JJR denotes earlier
T6549 11226-11228 IN denotes in
T6550 11229-11233 NNS denotes mice
T6551 11234-11238 WDT denotes that
T6552 11243-11249 VBN denotes passed
T6553 11239-11242 VBD denotes had
T6554 11250-11254 JJR denotes more
T6555 11260-11263 CD denotes one
T6556 11255-11259 IN denotes than
T6557 11264-11273 NN denotes pregnancy
T6558 11273-11274 . denotes .
T6559 11274-11495 sentence denotes There was no difference in the development of the disease between female mice that have only been pregnant with MHC mismatched males (B10.RIII) and female mice that only have been pregnant with MHC matched males (B10.Q).
T6560 11275-11280 EX denotes There
T6561 11281-11284 VBD denotes was
T6562 11285-11287 DT denotes no
T6563 11288-11298 NN denotes difference
T6564 11299-11301 IN denotes in
T6565 11302-11305 DT denotes the
T6566 11306-11317 NN denotes development
T6567 11318-11320 IN denotes of
T6568 11321-11324 DT denotes the
T6569 11325-11332 NN denotes disease
T6570 11333-11340 IN denotes between
T6571 11341-11347 JJ denotes female
T6572 11348-11352 NNS denotes mice
T6573 11353-11357 WDT denotes that
T6574 11368-11372 VBN denotes been
T6575 11358-11362 VBP denotes have
T6576 11363-11367 RB denotes only
T6577 11373-11381 JJ denotes pregnant
T6578 11382-11386 IN denotes with
T6579 11387-11390 NN denotes MHC
T6580 11391-11401 VBN denotes mismatched
T6581 11402-11407 NNS denotes males
T6582 11408-11409 -LRB- denotes (
T6583 11409-11417 NN denotes B10.RIII
T6584 11417-11418 -RRB- denotes )
T6585 11419-11422 CC denotes and
T6586 11423-11429 JJ denotes female
T6587 11430-11434 NNS denotes mice
T6588 11435-11439 WDT denotes that
T6589 11450-11454 VBN denotes been
T6590 11440-11444 RB denotes only
T6591 11445-11449 VBP denotes have
T6592 11455-11463 JJ denotes pregnant
T6593 11464-11468 IN denotes with
T6594 11469-11472 NN denotes MHC
T6595 11473-11480 VBN denotes matched
T6596 11481-11486 NNS denotes males
T6597 11487-11488 -LRB- denotes (
T6598 11488-11493 NN denotes B10.Q
T6599 11493-11494 -RRB- denotes )
T6600 11494-11495 . denotes .
T6854 11497-11500 JJ denotes New
T6855 11501-11505 NNS denotes loci
T6856 11506-11516 VBN denotes associated
T6857 11517-11521 IN denotes with
T6858 11522-11525 NN denotes CIA
T6859 11526-11528 IN denotes in
T6860 11529-11539 VBN denotes identified
T6861 11551-11555 NNS denotes mice
T6862 11540-11543 JJ denotes old
T6863 11544-11550 JJ denotes female
T6864 11555-11701 sentence denotes The genetic linkage analysis revealed one significant quantitative trait locus (QTL) located at 64–70 cM on chromosome 11 (Table 3 and Figure 2).
T6865 11556-11559 DT denotes The
T6866 11576-11584 NN denotes analysis
T6867 11560-11567 JJ denotes genetic
T6868 11568-11575 NN denotes linkage
T6869 11585-11593 VBD denotes revealed
T6870 11594-11597 CD denotes one
T6871 11629-11634 NN denotes locus
T6872 11598-11609 JJ denotes significant
T6873 11610-11622 JJ denotes quantitative
T6874 11623-11628 NN denotes trait
T6875 11635-11636 -LRB- denotes (
T6876 11636-11639 NN denotes QTL
T6877 11639-11640 -RRB- denotes )
T6878 11641-11648 VBN denotes located
T6879 11649-11651 IN denotes at
T6880 11652-11654 CD denotes 64
T6881 11655-11657 CD denotes 70
T6882 11654-11655 SYM denotes –
T6883 11658-11660 NN denotes cM
T6884 11661-11663 IN denotes on
T6885 11664-11674 NN denotes chromosome
T6886 11675-11677 CD denotes 11
T6887 11678-11679 -LRB- denotes (
T6888 11679-11684 NN denotes Table
T6889 11685-11686 CD denotes 3
T6890 11687-11690 CC denotes and
T6891 11691-11697 NN denotes Figure
T6892 11698-11699 CD denotes 2
T6893 11699-11700 -RRB- denotes )
T6894 11700-11701 . denotes .
T6895 11701-11897 sentence denotes This locus (denoted Cia40) gave significant LOD scores for the traits incidence (LOD = 4.1) and 'day of onset' (LOD = 4.0), and a suggestive LOD score for the trait 'arthritis score' (LOD = 3.3).
T6896 11702-11706 DT denotes This
T6897 11707-11712 NN denotes locus
T6898 11729-11733 VBD denotes gave
T6899 11713-11714 -LRB- denotes (
T6900 11714-11721 VBN denotes denoted
T6901 11722-11727 NN denotes Cia40
T6902 11727-11728 -RRB- denotes )
T6903 11734-11745 JJ denotes significant
T6904 11750-11756 NNS denotes scores
T6905 11746-11749 NN denotes LOD
T6906 11757-11760 IN denotes for
T6907 11761-11764 DT denotes the
T6908 11772-11781 NN denotes incidence
T6909 11765-11771 NNS denotes traits
T6910 11782-11783 -LRB- denotes (
T6911 11789-11792 CD denotes 4.1
T6912 11783-11786 NN denotes LOD
T6913 11787-11788 SYM denotes =
T6914 11792-11793 -RRB- denotes )
T6915 11794-11797 CC denotes and
T6916 11798-11799 `` denotes '
T6917 11799-11802 NN denotes day
T6918 11803-11805 IN denotes of
T6919 11806-11811 NN denotes onset
T6920 11811-11812 '' denotes '
T6921 11813-11814 -LRB- denotes (
T6922 11820-11823 CD denotes 4.0
T6923 11814-11817 NN denotes LOD
T6924 11818-11819 SYM denotes =
T6925 11823-11824 -RRB- denotes )
T6926 11824-11826 , denotes ,
T6927 11826-11829 CC denotes and
T6928 11830-11831 DT denotes a
T6929 11847-11852 NN denotes score
T6930 11832-11842 JJ denotes suggestive
T6931 11843-11846 NN denotes LOD
T6932 11853-11856 IN denotes for
T6933 11857-11860 DT denotes the
T6934 11878-11883 NN denotes score
T6935 11861-11866 NN denotes trait
T6936 11867-11868 `` denotes '
T6937 11868-11877 NN denotes arthritis
T6938 11883-11884 '' denotes '
T6939 11885-11886 -LRB- denotes (
T6940 11892-11895 CD denotes 3.3
T6941 11886-11889 NN denotes LOD
T6942 11890-11891 SYM denotes =
T6943 11895-11896 -RRB- denotes )
T6944 11896-11897 . denotes .
T6945 11897-12021 sentence denotes Another QTL of suggestive significance for the incidence of disease was identified around 27 cM on chromosome 1 (Figure 2).
T6946 11898-11905 DT denotes Another
T6947 11906-11909 NN denotes QTL
T6948 11970-11980 VBN denotes identified
T6949 11910-11912 IN denotes of
T6950 11913-11923 JJ denotes suggestive
T6951 11924-11936 NN denotes significance
T6952 11937-11940 IN denotes for
T6953 11941-11944 DT denotes the
T6954 11945-11954 NN denotes incidence
T6955 11955-11957 IN denotes of
T6956 11958-11965 NN denotes disease
T6957 11966-11969 VBD denotes was
T6958 11981-11987 IN denotes around
T6959 11988-11990 CD denotes 27
T6960 11991-11993 NN denotes cM
T6961 11994-11996 IN denotes on
T6962 11997-12007 NN denotes chromosome
T6963 12008-12009 CD denotes 1
T6964 12010-12011 -LRB- denotes (
T6965 12011-12017 NN denotes Figure
T6966 12018-12019 CD denotes 2
T6967 12019-12020 -RRB- denotes )
T6968 12020-12021 . denotes .
T6969 12021-12129 sentence denotes Finally, a suggestive QTL for the trait anti-CII antibody titer was identified on chromosome 13 (Figure 2).
T6970 12022-12029 RB denotes Finally
T6971 12090-12100 VBN denotes identified
T6972 12029-12031 , denotes ,
T6973 12031-12032 DT denotes a
T6974 12044-12047 NN denotes QTL
T6975 12033-12043 JJ denotes suggestive
T6976 12048-12051 IN denotes for
T6977 12052-12055 DT denotes the
T6978 12056-12061 NN denotes trait
T6979 12062-12070 JJ denotes anti-CII
T6980 12080-12085 NN denotes titer
T6981 12071-12079 NN denotes antibody
T6982 12086-12089 VBD denotes was
T6983 12101-12103 IN denotes on
T6984 12104-12114 NN denotes chromosome
T6985 12115-12117 CD denotes 13
T6986 12118-12119 -LRB- denotes (
T6987 12119-12125 NN denotes Figure
T6988 12126-12127 CD denotes 2
T6989 12127-12128 -RRB- denotes )
T6990 12128-12129 . denotes .
T9016 12142-12150 IN denotes Although
T9017 12151-12159 VBG denotes carrying
T9018 12222-12225 VBP denotes are
T9019 12160-12163 DT denotes the
T9020 12189-12195 NN denotes region
T9021 12164-12168 JJ denotes same
T9022 12169-12172 NN denotes CIA
T9023 12173-12184 JJ denotes susceptible
T9024 12172-12173 HYPH denotes -
T9025 12185-12188 NN denotes MHC
T9026 12195-12197 , denotes ,
T9027 12197-12200 DT denotes the
T9028 12217-12221 NNS denotes mice
T9029 12201-12204 NN denotes NFR
T9030 12205-12206 NN denotes N
T9031 12204-12205 HYPH denotes /
T9032 12207-12210 CC denotes and
T9033 12211-12216 NN denotes B10.Q
T9034 12226-12235 JJ denotes different
T9035 12236-12238 IN denotes in
T9036 12239-12246 JJ denotes several
T9037 12247-12255 NNS denotes respects
T9038 12255-12256 . denotes .
T9039 12256-12433 sentence denotes The NFR/N mouse, which is an inbred NMRI mouse of the H-2q haplotype, is larger in size than the B10.Q mouse and is also known for its extraordinarily good breeding properties.
T9040 12257-12260 DT denotes The
T9041 12267-12272 NN denotes mouse
T9042 12261-12264 NN denotes NFR
T9043 12265-12266 NN denotes N
T9044 12264-12265 HYPH denotes /
T9045 12327-12329 VBZ denotes is
T9046 12272-12274 , denotes ,
T9047 12274-12279 WDT denotes which
T9048 12280-12282 VBZ denotes is
T9049 12283-12285 DT denotes an
T9050 12298-12303 NN denotes mouse
T9051 12286-12292 JJ denotes inbred
T9052 12293-12297 NN denotes NMRI
T9053 12304-12306 IN denotes of
T9054 12307-12310 DT denotes the
T9055 12316-12325 NN denotes haplotype
T9056 12311-12312 NN denotes H
T9057 12313-12315 NN denotes 2q
T9058 12312-12313 HYPH denotes -
T9059 12325-12327 , denotes ,
T9060 12330-12336 JJR denotes larger
T9061 12337-12339 IN denotes in
T9062 12340-12344 NN denotes size
T9063 12345-12349 IN denotes than
T9064 12350-12353 DT denotes the
T9065 12360-12365 NN denotes mouse
T9066 12354-12359 NN denotes B10.Q
T9067 12366-12369 CC denotes and
T9068 12370-12372 VBZ denotes is
T9069 12378-12383 VBN denotes known
T9070 12373-12377 RB denotes also
T9071 12384-12387 IN denotes for
T9072 12388-12391 PRP$ denotes its
T9073 12422-12432 NNS denotes properties
T9074 12392-12407 RB denotes extraordinarily
T9075 12408-12412 JJ denotes good
T9076 12413-12421 NN denotes breeding
T9077 12432-12433 . denotes .
T9078 12433-12739 sentence denotes The mice used in the present study, (NFR/N × B10.Q) × B10.Q females, first underwent a genetic study of reproduction, in which a number of loci associated with breeding performance were identified (Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson Å, Holmdahl R, Mattsson R; unpublished data).
T9079 12434-12437 DT denotes The
T9080 12438-12442 NNS denotes mice
T9081 12509-12518 VBD denotes underwent
T9082 12443-12447 VBN denotes used
T9083 12448-12450 IN denotes in
T9084 12451-12454 DT denotes the
T9085 12463-12468 NN denotes study
T9086 12455-12462 JJ denotes present
T9087 12468-12470 , denotes ,
T9088 12470-12471 -LRB- denotes (
T9089 12475-12476 NN denotes N
T9090 12471-12474 NN denotes NFR
T9091 12474-12475 HYPH denotes /
T9092 12494-12501 NNS denotes females
T9093 12477-12478 SYM denotes ×
T9094 12479-12484 NN denotes B10.Q
T9095 12484-12485 -RRB- denotes )
T9096 12486-12487 SYM denotes ×
T9097 12488-12493 NN denotes B10.Q
T9098 12501-12503 , denotes ,
T9099 12503-12508 RB denotes first
T9100 12519-12520 DT denotes a
T9101 12529-12534 NN denotes study
T9102 12521-12528 JJ denotes genetic
T9103 12535-12537 IN denotes of
T9104 12538-12550 NN denotes reproduction
T9105 12550-12552 , denotes ,
T9106 12552-12554 IN denotes in
T9107 12620-12630 VBN denotes identified
T9108 12555-12560 WDT denotes which
T9109 12561-12562 DT denotes a
T9110 12563-12569 NN denotes number
T9111 12570-12572 IN denotes of
T9112 12573-12577 NNS denotes loci
T9113 12578-12588 VBN denotes associated
T9114 12589-12593 IN denotes with
T9115 12594-12602 NN denotes breeding
T9116 12603-12614 NN denotes performance
T9117 12615-12619 VBD denotes were
T9118 12631-12632 -LRB- denotes (
T9119 12632-12641 NNP denotes Liljander
T9120 12642-12643 NNP denotes M
T9121 12643-12645 , denotes ,
T9122 12645-12654 NNP denotes Sällström
T9123 12655-12657 NNP denotes MA
T9124 12657-12659 , denotes ,
T9125 12659-12668 NNP denotes Andersson
T9126 12669-12670 NNP denotes S
T9127 12670-12672 , denotes ,
T9128 12672-12680 NNP denotes Wernhoff
T9129 12681-12682 NNP denotes P
T9130 12682-12684 , denotes ,
T9131 12684-12693 NNP denotes Andersson
T9132 12694-12695 NNP denotes Å
T9133 12695-12697 , denotes ,
T9134 12697-12705 NNP denotes Holmdahl
T9135 12706-12707 NNP denotes R
T9136 12707-12709 , denotes ,
T9137 12709-12717 NNP denotes Mattsson
T9138 12718-12719 NNP denotes R
T9139 12719-12720 : denotes ;
T9140 12721-12732 JJ denotes unpublished
T9141 12733-12737 NNS denotes data
T9142 12737-12738 -RRB- denotes )
T9143 12738-12739 . denotes .
T9144 12739-12945 sentence denotes Since the parental strains differ in susceptibility to CIA, in spite of both having the MHC class II A beta genes [15], we wanted to test the susceptibility to inflammatory disease in mice from this cross.
T9145 12740-12745 IN denotes Since
T9146 12767-12773 VBP denotes differ
T9147 12746-12749 DT denotes the
T9148 12759-12766 NNS denotes strains
T9149 12750-12758 JJ denotes parental
T9150 12863-12869 VBD denotes wanted
T9151 12774-12776 IN denotes in
T9152 12777-12791 NN denotes susceptibility
T9153 12792-12794 IN denotes to
T9154 12795-12798 NN denotes CIA
T9155 12798-12800 , denotes ,
T9156 12800-12802 IN denotes in
T9157 12803-12808 NN denotes spite
T9158 12809-12811 IN denotes of
T9159 12812-12816 DT denotes both
T9160 12817-12823 VBG denotes having
T9161 12824-12827 DT denotes the
T9162 12848-12853 NNS denotes genes
T9163 12828-12831 NN denotes MHC
T9164 12832-12837 NN denotes class
T9165 12841-12842 NN denotes A
T9166 12838-12840 CD denotes II
T9167 12843-12847 NN denotes beta
T9168 12854-12855 -LRB- denotes [
T9169 12855-12857 CD denotes 15
T9170 12857-12858 -RRB- denotes ]
T9171 12858-12860 , denotes ,
T9172 12860-12862 PRP denotes we
T9173 12870-12872 TO denotes to
T9174 12873-12877 VB denotes test
T9175 12878-12881 DT denotes the
T9176 12882-12896 NN denotes susceptibility
T9177 12897-12899 IN denotes to
T9178 12900-12912 JJ denotes inflammatory
T9179 12913-12920 NN denotes disease
T9180 12921-12923 IN denotes in
T9181 12924-12928 NNS denotes mice
T9182 12929-12933 IN denotes from
T9183 12934-12938 DT denotes this
T9184 12939-12944 NN denotes cross
T9185 12944-12945 . denotes .
T9186 12945-13092 sentence denotes In fact, this situation gave an opportunity to study the genetic control of arthritis in aged multiparous females, a common situation in human RA.
T9187 12946-12948 IN denotes In
T9188 12970-12974 VBD denotes gave
T9189 12949-12953 NN denotes fact
T9190 12953-12955 , denotes ,
T9191 12955-12959 DT denotes this
T9192 12960-12969 NN denotes situation
T9193 12975-12977 DT denotes an
T9194 12978-12989 NN denotes opportunity
T9195 12990-12992 TO denotes to
T9196 12993-12998 VB denotes study
T9197 12999-13002 DT denotes the
T9198 13011-13018 NN denotes control
T9199 13003-13010 JJ denotes genetic
T9200 13019-13021 IN denotes of
T9201 13022-13031 NN denotes arthritis
T9202 13032-13034 IN denotes in
T9203 13035-13039 JJ denotes aged
T9204 13052-13059 NNS denotes females
T9205 13040-13051 JJ denotes multiparous
T9206 13059-13061 , denotes ,
T9207 13061-13062 DT denotes a
T9208 13070-13079 NN denotes situation
T9209 13063-13069 JJ denotes common
T9210 13080-13082 IN denotes in
T9211 13083-13088 JJ denotes human
T9212 13089-13091 NN denotes RA
T9213 13091-13092 . denotes .
T9214 13092-13162 sentence denotes This susceptibility was important to investigate for various reasons.
T9215 13093-13097 DT denotes This
T9216 13098-13112 NN denotes susceptibility
T9217 13113-13116 VBD denotes was
T9218 13117-13126 JJ denotes important
T9219 13127-13129 TO denotes to
T9220 13130-13141 VB denotes investigate
T9221 13142-13145 IN denotes for
T9222 13146-13153 JJ denotes various
T9223 13154-13161 NNS denotes reasons
T9224 13161-13162 . denotes .
T9225 13162-13326 sentence denotes The fact that the mice differed in their reproductive history made it possible to analyze whether this would significantly affect the incidence or severity of CIA.
T9226 13163-13166 DT denotes The
T9227 13167-13171 NN denotes fact
T9228 13225-13229 VBD denotes made
T9229 13172-13176 IN denotes that
T9230 13186-13194 VBD denotes differed
T9231 13177-13180 DT denotes the
T9232 13181-13185 NNS denotes mice
T9233 13195-13197 IN denotes in
T9234 13198-13203 PRP$ denotes their
T9235 13217-13224 NN denotes history
T9236 13204-13216 JJ denotes reproductive
T9237 13230-13232 PRP denotes it
T9238 13233-13241 JJ denotes possible
T9239 13242-13244 TO denotes to
T9240 13245-13252 VB denotes analyze
T9241 13253-13260 IN denotes whether
T9242 13286-13292 VB denotes affect
T9243 13261-13265 DT denotes this
T9244 13266-13271 MD denotes would
T9245 13272-13285 RB denotes significantly
T9246 13293-13296 DT denotes the
T9247 13297-13306 NN denotes incidence
T9248 13307-13309 CC denotes or
T9249 13310-13318 NN denotes severity
T9250 13319-13321 IN denotes of
T9251 13322-13325 NN denotes CIA
T9252 13325-13326 . denotes .
T9253 13326-13459 sentence denotes Second, almost all the linkage analyses performed for detection of CIA-associated loci in mice have been carried out with male mice.
T9254 13327-13333 RB denotes Second
T9255 13432-13439 VBN denotes carried
T9256 13333-13335 , denotes ,
T9257 13335-13341 RB denotes almost
T9258 13358-13366 NNS denotes analyses
T9259 13342-13345 PDT denotes all
T9260 13346-13349 DT denotes the
T9261 13350-13357 NN denotes linkage
T9262 13367-13376 VBN denotes performed
T9263 13377-13380 IN denotes for
T9264 13381-13390 NN denotes detection
T9265 13391-13393 IN denotes of
T9266 13394-13397 NN denotes CIA
T9267 13398-13408 VBN denotes associated
T9268 13397-13398 HYPH denotes -
T9269 13409-13413 NNS denotes loci
T9270 13414-13416 IN denotes in
T9271 13417-13421 NNS denotes mice
T9272 13422-13426 VBP denotes have
T9273 13427-13431 VBN denotes been
T9274 13440-13443 RP denotes out
T9275 13444-13448 IN denotes with
T9276 13449-13453 JJ denotes male
T9277 13454-13458 NNS denotes mice
T9278 13458-13459 . denotes .
T9279 13459-13579 sentence denotes Another reason is that the use of old multiparous mice mimicked the RA situation (older women is the major risk group).
T9280 13460-13467 DT denotes Another
T9281 13468-13474 NN denotes reason
T9282 13475-13477 VBZ denotes is
T9283 13478-13482 IN denotes that
T9284 13515-13523 VBD denotes mimicked
T9285 13483-13486 DT denotes the
T9286 13487-13490 NN denotes use
T9287 13491-13493 IN denotes of
T9288 13494-13497 JJ denotes old
T9289 13510-13514 NNS denotes mice
T9290 13498-13509 JJ denotes multiparous
T9291 13524-13527 DT denotes the
T9292 13531-13540 NN denotes situation
T9293 13528-13530 NN denotes RA
T9294 13541-13542 -LRB- denotes (
T9295 13554-13556 VBZ denotes is
T9296 13542-13547 JJR denotes older
T9297 13548-13553 NNS denotes women
T9298 13557-13560 DT denotes the
T9299 13572-13577 NN denotes group
T9300 13561-13566 JJ denotes major
T9301 13567-13571 NN denotes risk
T9302 13577-13578 -RRB- denotes )
T9303 13578-13579 . denotes .
T9304 13579-13792 sentence denotes Finally, the NFR/N strain had not previously been used in linkage analyses for detection of CIA-associated loci, which opened (up) the possibility of detecting new polymorphic genes of importance in this disease.
T9305 13580-13587 RB denotes Finally
T9306 13630-13634 VBN denotes used
T9307 13587-13589 , denotes ,
T9308 13589-13592 DT denotes the
T9309 13599-13605 NN denotes strain
T9310 13593-13596 NN denotes NFR
T9311 13597-13598 NN denotes N
T9312 13596-13597 HYPH denotes /
T9313 13606-13609 VBD denotes had
T9314 13610-13613 RB denotes not
T9315 13614-13624 RB denotes previously
T9316 13625-13629 VBN denotes been
T9317 13635-13637 IN denotes in
T9318 13638-13645 NN denotes linkage
T9319 13646-13654 NNS denotes analyses
T9320 13655-13658 IN denotes for
T9321 13659-13668 NN denotes detection
T9322 13669-13671 IN denotes of
T9323 13672-13675 NN denotes CIA
T9324 13676-13686 VBN denotes associated
T9325 13675-13676 HYPH denotes -
T9326 13687-13691 NNS denotes loci
T9327 13691-13693 , denotes ,
T9328 13693-13698 WDT denotes which
T9329 13699-13705 VBN denotes opened
T9330 13706-13707 -LRB- denotes (
T9331 13707-13709 RP denotes up
T9332 13709-13710 -RRB- denotes )
T9333 13711-13714 DT denotes the
T9334 13715-13726 NN denotes possibility
T9335 13727-13729 IN denotes of
T9336 13730-13739 VBG denotes detecting
T9337 13740-13743 JJ denotes new
T9338 13756-13761 NNS denotes genes
T9339 13744-13755 JJ denotes polymorphic
T9340 13762-13764 IN denotes of
T9341 13765-13775 NN denotes importance
T9342 13776-13778 IN denotes in
T9343 13779-13783 DT denotes this
T9344 13784-13791 NN denotes disease
T9345 13791-13792 . denotes .
T9346 13792-13952 sentence denotes The first conclusion from the present paper is that multiparity does not negatively influence the incidence or severity of CIA induced later in life (Table 2).
T9347 13793-13796 DT denotes The
T9348 13803-13813 NN denotes conclusion
T9349 13797-13802 JJ denotes first
T9350 13837-13839 VBZ denotes is
T9351 13814-13818 IN denotes from
T9352 13819-13822 DT denotes the
T9353 13831-13836 NN denotes paper
T9354 13823-13830 JJ denotes present
T9355 13840-13844 IN denotes that
T9356 13877-13886 VB denotes influence
T9357 13845-13856 NN denotes multiparity
T9358 13857-13861 VBZ denotes does
T9359 13862-13865 RB denotes not
T9360 13866-13876 RB denotes negatively
T9361 13887-13890 DT denotes the
T9362 13891-13900 NN denotes incidence
T9363 13901-13903 CC denotes or
T9364 13904-13912 NN denotes severity
T9365 13913-13915 IN denotes of
T9366 13916-13919 NN denotes CIA
T9367 13920-13927 VBN denotes induced
T9368 13928-13933 RB denotes later
T9369 13934-13936 IN denotes in
T9370 13937-13941 NN denotes life
T9371 13942-13943 -LRB- denotes (
T9372 13943-13948 NN denotes Table
T9373 13949-13950 CD denotes 2
T9374 13950-13951 -RRB- denotes )
T9375 13951-13952 . denotes .
T9376 13952-14164 sentence denotes This is in agreement with results from a recent study of RA in women, which similarly indicates that previous experience of pregnancy does not negatively affect the incidence or severity of RA later in life [8].
T9377 13953-13957 DT denotes This
T9378 13958-13960 VBZ denotes is
T9379 13961-13963 IN denotes in
T9380 13964-13973 NN denotes agreement
T9381 13974-13978 IN denotes with
T9382 13979-13986 NNS denotes results
T9383 13987-13991 IN denotes from
T9384 13992-13993 DT denotes a
T9385 14001-14006 NN denotes study
T9386 13994-14000 JJ denotes recent
T9387 14007-14009 IN denotes of
T9388 14010-14012 NN denotes RA
T9389 14013-14015 IN denotes in
T9390 14016-14021 NNS denotes women
T9391 14021-14023 , denotes ,
T9392 14023-14028 WDT denotes which
T9393 14039-14048 VBZ denotes indicates
T9394 14029-14038 RB denotes similarly
T9395 14049-14053 IN denotes that
T9396 14107-14113 VB denotes affect
T9397 14054-14062 JJ denotes previous
T9398 14063-14073 NN denotes experience
T9399 14074-14076 IN denotes of
T9400 14077-14086 NN denotes pregnancy
T9401 14087-14091 VBZ denotes does
T9402 14092-14095 RB denotes not
T9403 14096-14106 RB denotes negatively
T9404 14114-14117 DT denotes the
T9405 14118-14127 NN denotes incidence
T9406 14128-14130 CC denotes or
T9407 14131-14139 NN denotes severity
T9408 14140-14142 IN denotes of
T9409 14143-14145 NN denotes RA
T9410 14146-14151 RB denotes later
T9411 14152-14154 IN denotes in
T9412 14155-14159 NN denotes life
T9413 14160-14161 -LRB- denotes [
T9414 14161-14162 CD denotes 8
T9415 14162-14163 -RRB- denotes ]
T9416 14163-14164 . denotes .
T9417 14164-14271 sentence denotes It is worth noting that the situation is quite different if pregnancy is entered during ongoing arthritis.
T9418 14165-14167 PRP denotes It
T9419 14168-14170 VBZ denotes is
T9420 14171-14176 JJ denotes worth
T9421 14177-14183 VBG denotes noting
T9422 14184-14188 IN denotes that
T9423 14203-14205 VBZ denotes is
T9424 14189-14192 DT denotes the
T9425 14193-14202 NN denotes situation
T9426 14206-14211 RB denotes quite
T9427 14212-14221 JJ denotes different
T9428 14222-14224 IN denotes if
T9429 14238-14245 VBN denotes entered
T9430 14225-14234 NN denotes pregnancy
T9431 14235-14237 VBZ denotes is
T9432 14246-14252 IN denotes during
T9433 14253-14260 JJ denotes ongoing
T9434 14261-14270 NN denotes arthritis
T9435 14270-14271 . denotes .
T9436 14271-14420 sentence denotes This will normally lead to a temporary remission of the disease in both mice and humans, followed by an exacerbation phase after delivery [7,10,11].
T9437 14272-14276 DT denotes This
T9438 14291-14295 VB denotes lead
T9439 14277-14281 MD denotes will
T9440 14282-14290 RB denotes normally
T9441 14296-14298 IN denotes to
T9442 14299-14300 DT denotes a
T9443 14311-14320 NN denotes remission
T9444 14301-14310 JJ denotes temporary
T9445 14321-14323 IN denotes of
T9446 14324-14327 DT denotes the
T9447 14328-14335 NN denotes disease
T9448 14336-14338 IN denotes in
T9449 14339-14343 CC denotes both
T9450 14344-14348 NNS denotes mice
T9451 14349-14352 CC denotes and
T9452 14353-14359 NNS denotes humans
T9453 14359-14361 , denotes ,
T9454 14361-14369 VBN denotes followed
T9455 14370-14372 IN denotes by
T9456 14373-14375 DT denotes an
T9457 14389-14394 NN denotes phase
T9458 14376-14388 NN denotes exacerbation
T9459 14395-14400 IN denotes after
T9460 14401-14409 NN denotes delivery
T9461 14410-14411 -LRB- denotes [
T9462 14416-14418 CD denotes 11
T9463 14411-14412 CD denotes 7
T9464 14412-14413 , denotes ,
T9465 14413-14415 CD denotes 10
T9466 14415-14416 , denotes ,
T9467 14418-14419 -RRB- denotes ]
T9468 14419-14420 . denotes .
T9469 14420-14647 sentence denotes The second conclusion from this study is that loci of possible importance for CIA have been detected, two associated with arthritis susceptibility (chromosomes 1 and 11) and one associated with anti-CII titers (chromosome 13).
T9470 14421-14424 DT denotes The
T9471 14432-14442 NN denotes conclusion
T9472 14425-14431 JJ denotes second
T9473 14459-14461 VBZ denotes is
T9474 14443-14447 IN denotes from
T9475 14448-14452 DT denotes this
T9476 14453-14458 NN denotes study
T9477 14462-14466 IN denotes that
T9478 14513-14521 VBN denotes detected
T9479 14467-14471 NNS denotes loci
T9480 14472-14474 IN denotes of
T9481 14475-14483 JJ denotes possible
T9482 14484-14494 NN denotes importance
T9483 14495-14498 IN denotes for
T9484 14499-14502 NN denotes CIA
T9485 14503-14507 VBP denotes have
T9486 14508-14512 VBN denotes been
T9487 14521-14523 , denotes ,
T9488 14523-14526 CD denotes two
T9489 14527-14537 VBN denotes associated
T9490 14538-14542 IN denotes with
T9491 14543-14552 NN denotes arthritis
T9492 14553-14567 NN denotes susceptibility
T9493 14568-14569 -LRB- denotes (
T9494 14569-14580 NNS denotes chromosomes
T9495 14581-14582 CD denotes 1
T9496 14583-14586 CC denotes and
T9497 14587-14589 CD denotes 11
T9498 14589-14590 -RRB- denotes )
T9499 14591-14594 CC denotes and
T9500 14595-14598 CD denotes one
T9501 14599-14609 VBN denotes associated
T9502 14610-14614 IN denotes with
T9503 14615-14623 JJ denotes anti-CII
T9504 14624-14630 NNS denotes titers
T9505 14631-14632 -LRB- denotes (
T9506 14632-14642 NN denotes chromosome
T9507 14643-14645 CD denotes 13
T9508 14645-14646 -RRB- denotes )
T9509 14646-14647 . denotes .
T9510 14647-14780 sentence denotes Some arthritis loci have previously been identified on chromosome 1: Cia15 at 8 cM [16], Cia20 at 44 cM [16] and Cia9 at 92 cM [17].
T9511 14648-14652 DT denotes Some
T9512 14663-14667 NNS denotes loci
T9513 14653-14662 NN denotes arthritis
T9514 14689-14699 VBN denotes identified
T9515 14668-14672 VBP denotes have
T9516 14673-14683 RB denotes previously
T9517 14684-14688 VBN denotes been
T9518 14700-14702 IN denotes on
T9519 14703-14713 NN denotes chromosome
T9520 14714-14715 CD denotes 1
T9521 14715-14717 : denotes :
T9522 14717-14722 NN denotes Cia15
T9523 14723-14725 IN denotes at
T9524 14726-14727 CD denotes 8
T9525 14728-14730 NN denotes cM
T9526 14731-14732 -LRB- denotes [
T9527 14732-14734 CD denotes 16
T9528 14734-14735 -RRB- denotes ]
T9529 14735-14737 , denotes ,
T9530 14737-14742 NN denotes Cia20
T9531 14743-14745 IN denotes at
T9532 14746-14748 CD denotes 44
T9533 14749-14751 NN denotes cM
T9534 14752-14753 -LRB- denotes [
T9535 14753-14755 CD denotes 16
T9536 14755-14756 -RRB- denotes ]
T9537 14757-14760 CC denotes and
T9538 14761-14765 NN denotes Cia9
T9539 14766-14768 IN denotes at
T9540 14769-14771 CD denotes 92
T9541 14772-14774 NN denotes cM
T9542 14775-14776 -LRB- denotes [
T9543 14776-14778 CD denotes 17
T9544 14778-14779 -RRB- denotes ]
T9545 14779-14780 . denotes .
T9546 14780-14885 sentence denotes However, none of these loci appears to be close to the locus found on chromosome 1 in the present study.
T9547 14781-14788 RB denotes However
T9548 14809-14816 VBZ denotes appears
T9549 14788-14790 , denotes ,
T9550 14790-14794 NN denotes none
T9551 14795-14797 IN denotes of
T9552 14798-14803 DT denotes these
T9553 14804-14808 NNS denotes loci
T9554 14817-14819 TO denotes to
T9555 14820-14822 VB denotes be
T9556 14823-14828 RB denotes close
T9557 14829-14831 IN denotes to
T9558 14832-14835 DT denotes the
T9559 14836-14841 NN denotes locus
T9560 14842-14847 VBN denotes found
T9561 14848-14850 IN denotes on
T9562 14851-14861 NN denotes chromosome
T9563 14862-14863 CD denotes 1
T9564 14864-14866 IN denotes in
T9565 14867-14870 DT denotes the
T9566 14879-14884 NN denotes study
T9567 14871-14878 JJ denotes present
T9568 14884-14885 . denotes .
T9569 14885-15088 sentence denotes The newly identified Cia40 locus includes the Ctla4 (CD152) gene, which is a strong candidate associated with spontaneous diabetes identified in crosses between C57Bl and nonobese diabetic strains [18].
T9570 14886-14889 DT denotes The
T9571 14913-14918 NN denotes locus
T9572 14890-14895 RB denotes newly
T9573 14896-14906 VBN denotes identified
T9574 14907-14912 NN denotes Cia40
T9575 14919-14927 VBZ denotes includes
T9576 14928-14931 DT denotes the
T9577 14946-14950 NN denotes gene
T9578 14932-14937 NN denotes Ctla4
T9579 14938-14939 -LRB- denotes (
T9580 14939-14944 NN denotes CD152
T9581 14944-14945 -RRB- denotes )
T9582 14950-14952 , denotes ,
T9583 14952-14957 WDT denotes which
T9584 14958-14960 VBZ denotes is
T9585 14961-14962 DT denotes a
T9586 14970-14979 NN denotes candidate
T9587 14963-14969 JJ denotes strong
T9588 14980-14990 VBN denotes associated
T9589 14991-14995 IN denotes with
T9590 14996-15007 JJ denotes spontaneous
T9591 15008-15016 NN denotes diabetes
T9592 15017-15027 VBN denotes identified
T9593 15028-15030 IN denotes in
T9594 15031-15038 NNS denotes crosses
T9595 15039-15046 IN denotes between
T9596 15047-15052 NN denotes C57Bl
T9597 15053-15056 CC denotes and
T9598 15057-15065 JJ denotes nonobese
T9599 15075-15082 NNS denotes strains
T9600 15066-15074 JJ denotes diabetic
T9601 15083-15084 -LRB- denotes [
T9602 15084-15086 CD denotes 18
T9603 15086-15087 -RRB- denotes ]
T9604 15087-15088 . denotes .
T9605 15088-15295 sentence denotes Analyses of CIA in crosses of the same backgrounds, however, did not identify a linkage to this locus, suggesting that the polymorphism underlying Cia40 differs from the genes associated with diabetes [18].
T9606 15089-15097 NNS denotes Analyses
T9607 15158-15166 VB denotes identify
T9608 15098-15100 IN denotes of
T9609 15101-15104 NN denotes CIA
T9610 15105-15107 IN denotes in
T9611 15108-15115 NNS denotes crosses
T9612 15116-15118 IN denotes of
T9613 15119-15122 DT denotes the
T9614 15128-15139 NNS denotes backgrounds
T9615 15123-15127 JJ denotes same
T9616 15139-15141 , denotes ,
T9617 15141-15148 RB denotes however
T9618 15148-15150 , denotes ,
T9619 15150-15153 VBD denotes did
T9620 15154-15157 RB denotes not
T9621 15167-15168 DT denotes a
T9622 15169-15176 NN denotes linkage
T9623 15177-15179 IN denotes to
T9624 15180-15184 DT denotes this
T9625 15185-15190 NN denotes locus
T9626 15190-15192 , denotes ,
T9627 15192-15202 VBG denotes suggesting
T9628 15203-15207 IN denotes that
T9629 15242-15249 VBZ denotes differs
T9630 15208-15211 DT denotes the
T9631 15212-15224 NN denotes polymorphism
T9632 15225-15235 VBG denotes underlying
T9633 15236-15241 NN denotes Cia40
T9634 15250-15254 IN denotes from
T9635 15255-15258 DT denotes the
T9636 15259-15264 NNS denotes genes
T9637 15265-15275 VBN denotes associated
T9638 15276-15280 IN denotes with
T9639 15281-15289 NN denotes diabetes
T9640 15290-15291 -LRB- denotes [
T9641 15291-15293 CD denotes 18
T9642 15293-15294 -RRB- denotes ]
T9643 15294-15295 . denotes .
T9644 15295-15556 sentence denotes Interestingly, Bauer and colleagues previously identified a locus (Cia28) associated with anti-CII antibody production at 53 cM on chromosome 13 [19], which is approximately at the same position as where we find the linkage for this trait in the present study.
T9645 15296-15309 RB denotes Interestingly
T9646 15343-15353 VBD denotes identified
T9647 15309-15311 , denotes ,
T9648 15311-15316 NNP denotes Bauer
T9649 15317-15320 CC denotes and
T9650 15321-15331 NNS denotes colleagues
T9651 15332-15342 RB denotes previously
T9652 15354-15355 DT denotes a
T9653 15356-15361 NN denotes locus
T9654 15362-15363 -LRB- denotes (
T9655 15363-15368 NN denotes Cia28
T9656 15368-15369 -RRB- denotes )
T9657 15370-15380 VBN denotes associated
T9658 15381-15385 IN denotes with
T9659 15386-15394 JJ denotes anti-CII
T9660 15404-15414 NN denotes production
T9661 15395-15403 NN denotes antibody
T9662 15415-15417 IN denotes at
T9663 15418-15420 CD denotes 53
T9664 15421-15423 NN denotes cM
T9665 15424-15426 IN denotes on
T9666 15427-15437 NN denotes chromosome
T9667 15438-15440 CD denotes 13
T9668 15441-15442 -LRB- denotes [
T9669 15442-15444 CD denotes 19
T9670 15444-15445 -RRB- denotes ]
T9671 15445-15447 , denotes ,
T9672 15447-15452 WDT denotes which
T9673 15453-15455 VBZ denotes is
T9674 15456-15469 RB denotes approximately
T9675 15470-15472 IN denotes at
T9676 15473-15476 DT denotes the
T9677 15482-15490 NN denotes position
T9678 15477-15481 JJ denotes same
T9679 15491-15493 IN denotes as
T9680 15494-15499 WRB denotes where
T9681 15503-15507 VBP denotes find
T9682 15500-15502 PRP denotes we
T9683 15508-15511 DT denotes the
T9684 15512-15519 NN denotes linkage
T9685 15520-15523 IN denotes for
T9686 15524-15528 DT denotes this
T9687 15529-15534 NN denotes trait
T9688 15535-15537 IN denotes in
T9689 15538-15541 DT denotes the
T9690 15550-15555 NN denotes study
T9691 15542-15549 JJ denotes present
T9692 15555-15556 . denotes .
T9693 15556-15655 sentence denotes It is therefore most likely that the QTL we have identified on chromosome 13 is the same as Cia28.
T9694 15557-15559 PRP denotes It
T9695 15560-15562 VBZ denotes is
T9696 15563-15572 RB denotes therefore
T9697 15573-15577 RBS denotes most
T9698 15578-15584 JJ denotes likely
T9699 15585-15589 IN denotes that
T9700 15634-15636 VBZ denotes is
T9701 15590-15593 DT denotes the
T9702 15594-15597 NN denotes QTL
T9703 15598-15600 PRP denotes we
T9704 15606-15616 VBN denotes identified
T9705 15601-15605 VBP denotes have
T9706 15617-15619 IN denotes on
T9707 15620-15630 NN denotes chromosome
T9708 15631-15633 CD denotes 13
T9709 15637-15640 DT denotes the
T9710 15641-15645 JJ denotes same
T9711 15646-15648 IN denotes as
T9712 15649-15654 NN denotes Cia28
T9713 15654-15655 . denotes .
T9714 15655-15953 sentence denotes Since the possible new locus of potential interest on chromosome 1 was of suggestive significance, and since the locus identified on chromosome 13 probably is Cia28, we are now paying special attention to the significant QTL for CIA incidence detected at 60–70 cM on chromosome 11 (denoted Cia40).
T9715 15656-15661 IN denotes Since
T9716 15723-15726 VBD denotes was
T9717 15662-15665 DT denotes the
T9718 15679-15684 NN denotes locus
T9719 15666-15674 JJ denotes possible
T9720 15675-15678 JJ denotes new
T9721 15685-15687 IN denotes of
T9722 15688-15697 JJ denotes potential
T9723 15698-15706 NN denotes interest
T9724 15707-15709 IN denotes on
T9725 15710-15720 NN denotes chromosome
T9726 15721-15722 CD denotes 1
T9727 15833-15839 VBG denotes paying
T9728 15727-15729 IN denotes of
T9729 15730-15740 JJ denotes suggestive
T9730 15741-15753 NN denotes significance
T9731 15753-15755 , denotes ,
T9732 15755-15758 CC denotes and
T9733 15759-15764 IN denotes since
T9734 15812-15814 VBZ denotes is
T9735 15765-15768 DT denotes the
T9736 15769-15774 NN denotes locus
T9737 15775-15785 VBN denotes identified
T9738 15786-15788 IN denotes on
T9739 15789-15799 NN denotes chromosome
T9740 15800-15802 CD denotes 13
T9741 15803-15811 RB denotes probably
T9742 15815-15820 NN denotes Cia28
T9743 15820-15822 , denotes ,
T9744 15822-15824 PRP denotes we
T9745 15825-15828 VBP denotes are
T9746 15829-15832 RB denotes now
T9747 15840-15847 JJ denotes special
T9748 15848-15857 NN denotes attention
T9749 15858-15860 IN denotes to
T9750 15861-15864 DT denotes the
T9751 15877-15880 NN denotes QTL
T9752 15865-15876 JJ denotes significant
T9753 15881-15884 IN denotes for
T9754 15885-15888 NN denotes CIA
T9755 15889-15898 NN denotes incidence
T9756 15899-15907 VBN denotes detected
T9757 15908-15910 IN denotes at
T9758 15911-15913 CD denotes 60
T9759 15914-15916 CD denotes 70
T9760 15913-15914 SYM denotes –
T9761 15917-15919 NN denotes cM
T9762 15920-15922 IN denotes on
T9763 15923-15933 NN denotes chromosome
T9764 15934-15936 CD denotes 11
T9765 15937-15938 -LRB- denotes (
T9766 15938-15945 VBN denotes denoted
T9767 15946-15951 NN denotes Cia40
T9768 15951-15952 -RRB- denotes )
T9769 15952-15953 . denotes .
T9770 15953-16150 sentence denotes No other CIA genes have previously been typed in this region, but the central part of chromosome 11 is known to contain a number of inflammation loci, such as Eae22, Eae6b, Eae23 and Eae7 [20-22].
T9771 15954-15956 DT denotes No
T9772 15967-15972 NNS denotes genes
T9773 15957-15962 JJ denotes other
T9774 15963-15966 NN denotes CIA
T9775 15994-15999 VBN denotes typed
T9776 15973-15977 VBP denotes have
T9777 15978-15988 RB denotes previously
T9778 15989-15993 VBN denotes been
T9779 16000-16002 IN denotes in
T9780 16003-16007 DT denotes this
T9781 16008-16014 NN denotes region
T9782 16014-16016 , denotes ,
T9783 16016-16019 CC denotes but
T9784 16020-16023 DT denotes the
T9785 16032-16036 NN denotes part
T9786 16024-16031 JJ denotes central
T9787 16057-16062 VBN denotes known
T9788 16037-16039 IN denotes of
T9789 16040-16050 NN denotes chromosome
T9790 16051-16053 CD denotes 11
T9791 16054-16056 VBZ denotes is
T9792 16063-16065 TO denotes to
T9793 16066-16073 VB denotes contain
T9794 16074-16075 DT denotes a
T9795 16076-16082 NN denotes number
T9796 16083-16085 IN denotes of
T9797 16086-16098 NN denotes inflammation
T9798 16099-16103 NNS denotes loci
T9799 16103-16105 , denotes ,
T9800 16105-16109 JJ denotes such
T9801 16110-16112 IN denotes as
T9802 16113-16118 NN denotes Eae22
T9803 16118-16120 , denotes ,
T9804 16120-16125 NN denotes Eae6b
T9805 16125-16127 , denotes ,
T9806 16127-16132 NN denotes Eae23
T9807 16133-16136 CC denotes and
T9808 16137-16141 NN denotes Eae7
T9809 16142-16143 -LRB- denotes [
T9810 16143-16145 CD denotes 20
T9811 16145-16146 SYM denotes -
T9812 16146-16148 CD denotes 22
T9813 16148-16149 -RRB- denotes ]
T9814 16149-16150 . denotes .
T9815 16150-16278 sentence denotes One QTL for proteoglycan-induced arthritis, which was female specific for disease onset, have also been found on chromosome 11.
T9816 16151-16154 CD denotes One
T9817 16155-16158 NN denotes QTL
T9818 16255-16260 VBN denotes found
T9819 16159-16162 IN denotes for
T9820 16163-16175 NN denotes proteoglycan
T9821 16176-16183 VBN denotes induced
T9822 16175-16176 HYPH denotes -
T9823 16184-16193 NN denotes arthritis
T9824 16193-16195 , denotes ,
T9825 16195-16200 WDT denotes which
T9826 16201-16204 VBD denotes was
T9827 16205-16211 JJ denotes female
T9828 16212-16220 JJ denotes specific
T9829 16221-16224 IN denotes for
T9830 16225-16232 NN denotes disease
T9831 16233-16238 NN denotes onset
T9832 16238-16240 , denotes ,
T9833 16240-16244 VBP denotes have
T9834 16245-16249 RB denotes also
T9835 16250-16254 VBN denotes been
T9836 16261-16263 IN denotes on
T9837 16264-16274 NN denotes chromosome
T9838 16275-16277 CD denotes 11
T9839 16277-16278 . denotes .
T9840 16278-16373 sentence denotes Although this locus (Pgia28) is not located in the vicinity of Cia40, it is worth noting [23].
T9841 16279-16287 IN denotes Although
T9842 16315-16322 VBN denotes located
T9843 16288-16292 DT denotes this
T9844 16293-16298 NN denotes locus
T9845 16299-16300 -LRB- denotes (
T9846 16300-16306 NN denotes Pgia28
T9847 16306-16307 -RRB- denotes )
T9848 16308-16310 VBZ denotes is
T9849 16311-16314 RB denotes not
T9850 16352-16354 VBZ denotes is
T9851 16323-16325 IN denotes in
T9852 16326-16329 DT denotes the
T9853 16330-16338 NN denotes vicinity
T9854 16339-16341 IN denotes of
T9855 16342-16347 NN denotes Cia40
T9856 16347-16349 , denotes ,
T9857 16349-16351 PRP denotes it
T9858 16355-16360 JJ denotes worth
T9859 16361-16367 VBG denotes noting
T9860 16368-16369 -LRB- denotes [
T9861 16369-16371 CD denotes 23
T9862 16371-16372 -RRB- denotes ]
T9863 16372-16373 . denotes .
T9864 16373-16472 sentence denotes The mouse chromosome 11 contains several genes that are highly conserved with human chromosome 17.
T9865 16374-16377 DT denotes The
T9866 16384-16394 NN denotes chromosome
T9867 16378-16383 NN denotes mouse
T9868 16398-16406 VBZ denotes contains
T9869 16395-16397 CD denotes 11
T9870 16407-16414 JJ denotes several
T9871 16415-16420 NNS denotes genes
T9872 16421-16425 WDT denotes that
T9873 16426-16429 VBP denotes are
T9874 16430-16436 RB denotes highly
T9875 16437-16446 JJ denotes conserved
T9876 16447-16451 IN denotes with
T9877 16452-16457 JJ denotes human
T9878 16458-16468 NN denotes chromosome
T9879 16469-16471 CD denotes 17
T9880 16471-16472 . denotes .
T9881 16472-16542 sentence denotes Linkages for human RA have been found in this particular region [24].
T9882 16473-16481 NNS denotes Linkages
T9883 16505-16510 VBN denotes found
T9884 16482-16485 IN denotes for
T9885 16486-16491 JJ denotes human
T9886 16492-16494 NN denotes RA
T9887 16495-16499 VBP denotes have
T9888 16500-16504 VBN denotes been
T9889 16511-16513 IN denotes in
T9890 16514-16518 DT denotes this
T9891 16530-16536 NN denotes region
T9892 16519-16529 JJ denotes particular
T9893 16537-16538 -LRB- denotes [
T9894 16538-16540 CD denotes 24
T9895 16540-16541 -RRB- denotes ]
T9896 16541-16542 . denotes .
T9897 16542-16683 sentence denotes Another interesting locus is Cia5 on the homolog rat chromosome 10, which regulates the severity of CIA and pristane-induced arthritis [25].
T9898 16543-16550 DT denotes Another
T9899 16563-16568 NN denotes locus
T9900 16551-16562 JJ denotes interesting
T9901 16569-16571 VBZ denotes is
T9902 16572-16576 NN denotes Cia5
T9903 16577-16579 IN denotes on
T9904 16580-16583 DT denotes the
T9905 16584-16591 NN denotes homolog
T9906 16592-16595 NN denotes rat
T9907 16596-16606 NN denotes chromosome
T9908 16607-16609 CD denotes 10
T9909 16609-16611 , denotes ,
T9910 16611-16616 WDT denotes which
T9911 16617-16626 VBZ denotes regulates
T9912 16627-16630 DT denotes the
T9913 16631-16639 NN denotes severity
T9914 16640-16642 IN denotes of
T9915 16643-16646 NN denotes CIA
T9916 16647-16650 CC denotes and
T9917 16651-16659 NN denotes pristane
T9918 16660-16667 VBN denotes induced
T9919 16659-16660 HYPH denotes -
T9920 16668-16677 NN denotes arthritis
T9921 16678-16679 -LRB- denotes [
T9922 16679-16681 CD denotes 25
T9923 16681-16682 -RRB- denotes ]
T9924 16682-16683 . denotes .
T9925 16683-17007 sentence denotes Interestingly, from studies with the same cross, we have previously detected a significant QTL denoted Pregq2 for the trait 'pregnancy frequency' in the very same region as Cia40 (peak at 64–70 cM on chromosome 11) (Liljander M, Sällström MA, Andersson S, Wernhoff P, Andersson Å, Holmdahl R, Mattsson R, unpublished data).
T9926 16684-16697 RB denotes Interestingly
T9927 16752-16760 VBN denotes detected
T9928 16697-16699 , denotes ,
T9929 16699-16703 IN denotes from
T9930 16704-16711 NNS denotes studies
T9931 16712-16716 IN denotes with
T9932 16717-16720 DT denotes the
T9933 16726-16731 NN denotes cross
T9934 16721-16725 JJ denotes same
T9935 16731-16733 , denotes ,
T9936 16733-16735 PRP denotes we
T9937 16736-16740 VBP denotes have
T9938 16741-16751 RB denotes previously
T9939 16761-16762 DT denotes a
T9940 16775-16778 NN denotes QTL
T9941 16763-16774 JJ denotes significant
T9942 16779-16786 VBN denotes denoted
T9943 16787-16793 NN denotes Pregq2
T9944 16794-16797 IN denotes for
T9945 16798-16801 DT denotes the
T9946 16802-16807 NN denotes trait
T9947 16808-16809 `` denotes '
T9948 16809-16818 NN denotes pregnancy
T9949 16819-16828 NN denotes frequency
T9950 16828-16829 '' denotes '
T9951 16830-16832 IN denotes in
T9952 16833-16836 DT denotes the
T9953 16847-16853 NN denotes region
T9954 16837-16841 RB denotes very
T9955 16842-16846 JJ denotes same
T9956 16854-16856 IN denotes as
T9957 16857-16862 NN denotes Cia40
T9958 16863-16864 -LRB- denotes (
T9959 16864-16868 NN denotes peak
T9960 16869-16871 IN denotes at
T9961 16872-16874 CD denotes 64
T9962 16875-16877 CD denotes 70
T9963 16874-16875 SYM denotes –
T9964 16878-16880 NN denotes cM
T9965 16881-16883 IN denotes on
T9966 16884-16894 NN denotes chromosome
T9967 16895-16897 CD denotes 11
T9968 16897-16898 -RRB- denotes )
T9969 16899-16900 -LRB- denotes (
T9970 16900-16909 NNP denotes Liljander
T9971 16910-16911 NNP denotes M
T9972 16911-16913 , denotes ,
T9973 16913-16922 NNP denotes Sällström
T9974 16923-16925 NNP denotes MA
T9975 16925-16927 , denotes ,
T9976 16927-16936 NNP denotes Andersson
T9977 16937-16938 NNP denotes S
T9978 16938-16940 , denotes ,
T9979 16940-16948 NNP denotes Wernhoff
T9980 16949-16950 NNP denotes P
T9981 16950-16952 , denotes ,
T9982 16952-16961 NNP denotes Andersson
T9983 16962-16963 NNP denotes Å
T9984 16963-16965 , denotes ,
T9985 16965-16973 NNP denotes Holmdahl
T9986 16974-16975 NNP denotes R
T9987 16975-16977 , denotes ,
T9988 16977-16985 NNP denotes Mattsson
T9989 16986-16987 NNP denotes R
T9990 16987-16989 , denotes ,
T9991 16989-17000 JJ denotes unpublished
T9992 17001-17005 NNS denotes data
T9993 17005-17006 -RRB- denotes )
T9994 17006-17007 . denotes .
T9995 17007-17163 sentence denotes This means that this region contains genes affecting the CIA incidence in multiparous mice in addition to the rate of successful deliveries in female mice.
T9996 17008-17012 DT denotes This
T9997 17013-17018 VBZ denotes means
T9998 17019-17023 IN denotes that
T9999 17036-17044 VBZ denotes contains
T10000 17024-17028 DT denotes this
T10001 17029-17035 NN denotes region
T10002 17045-17050 NNS denotes genes
T10003 17051-17060 VBG denotes affecting
T10004 17061-17064 DT denotes the
T10005 17069-17078 NN denotes incidence
T10006 17065-17068 NN denotes CIA
T10007 17079-17081 IN denotes in
T10008 17082-17093 JJ denotes multiparous
T10009 17094-17098 NNS denotes mice
T10010 17099-17101 IN denotes in
T10011 17102-17110 NN denotes addition
T10012 17111-17113 IN denotes to
T10013 17114-17117 DT denotes the
T10014 17118-17122 NN denotes rate
T10015 17123-17125 IN denotes of
T10016 17126-17136 JJ denotes successful
T10017 17137-17147 NNS denotes deliveries
T10018 17148-17150 IN denotes in
T10019 17151-17157 JJ denotes female
T10020 17158-17162 NNS denotes mice
T10021 17162-17163 . denotes .
T10022 17163-17366 sentence denotes The 'pregnancy rate' in mice is defined as successful pregnancies per detected vaginal plug, a phenotype associated with early pregnancy failure, which in turn possibly could have an inflammatory cause.
T10023 17164-17167 DT denotes The
T10024 17179-17183 NN denotes rate
T10025 17168-17169 `` denotes '
T10026 17169-17178 NN denotes pregnancy
T10027 17196-17203 VBN denotes defined
T10028 17183-17184 '' denotes '
T10029 17185-17187 IN denotes in
T10030 17188-17192 NNS denotes mice
T10031 17193-17195 VBZ denotes is
T10032 17204-17206 IN denotes as
T10033 17207-17217 JJ denotes successful
T10034 17218-17229 NNS denotes pregnancies
T10035 17230-17233 IN denotes per
T10036 17234-17242 VBN denotes detected
T10037 17251-17255 NN denotes plug
T10038 17243-17250 JJ denotes vaginal
T10039 17255-17257 , denotes ,
T10040 17257-17258 DT denotes a
T10041 17259-17268 NN denotes phenotype
T10042 17269-17279 VBN denotes associated
T10043 17280-17284 IN denotes with
T10044 17285-17290 JJ denotes early
T10045 17301-17308 NN denotes failure
T10046 17291-17300 NN denotes pregnancy
T10047 17308-17310 , denotes ,
T10048 17310-17315 WDT denotes which
T10049 17339-17343 VB denotes have
T10050 17316-17318 IN denotes in
T10051 17319-17323 NN denotes turn
T10052 17324-17332 RB denotes possibly
T10053 17333-17338 MD denotes could
T10054 17344-17346 DT denotes an
T10055 17360-17365 NN denotes cause
T10056 17347-17359 JJ denotes inflammatory
T10057 17365-17366 . denotes .
T10058 17366-17439 sentence denotes We cannot exclude that the same gene(s) are affecting both these traits.
T10059 17367-17369 PRP denotes We
T10212 17452-17455 PRP$ denotes Our
T10213 17456-17463 NNS denotes results
T10214 17464-17468 VBP denotes show
T10215 17469-17473 IN denotes that
T10216 17506-17515 VB denotes influence
T10217 17474-17485 NN denotes multiparity
T10218 17486-17490 VBZ denotes does
T10219 17491-17494 RB denotes not
T10220 17495-17505 RB denotes negatively
T10221 17516-17519 DT denotes the
T10222 17520-17529 NN denotes incidence
T10223 17530-17532 CC denotes or
T10224 17533-17541 NN denotes severity
T10225 17542-17544 IN denotes of
T10226 17545-17548 NN denotes CIA
T10227 17549-17556 VBN denotes induced
T10228 17557-17562 RB denotes later
T10229 17563-17565 IN denotes in
T10230 17566-17570 NN denotes life
T10231 17570-17571 . denotes .
T10232 17571-17686 sentence denotes Furthermore, two new loci linked to CIA susceptibility were detected on chromosome 11 (Cia40) and on chromosome 1.
T10233 17572-17583 RB denotes Furthermore
T10234 17632-17640 VBN denotes detected
T10235 17583-17585 , denotes ,
T10236 17585-17588 CD denotes two
T10237 17593-17597 NNS denotes loci
T10238 17589-17592 JJ denotes new
T10239 17598-17604 VBN denotes linked
T10240 17605-17607 IN denotes to
T10241 17608-17611 NN denotes CIA
T10242 17612-17626 NN denotes susceptibility
T10243 17627-17631 VBD denotes were
T10244 17641-17643 IN denotes on
T10245 17644-17654 NN denotes chromosome
T10246 17655-17657 CD denotes 11
T10247 17658-17659 -LRB- denotes (
T10248 17659-17664 NN denotes Cia40
T10249 17664-17665 -RRB- denotes )
T10250 17666-17669 CC denotes and
T10251 17670-17672 IN denotes on
T10252 17673-17683 NN denotes chromosome
T10253 17684-17685 CD denotes 1
T10254 17685-17686 . denotes .
T10255 17686-17820 sentence denotes We detected on chromosome 13 a locus associated with anti-CII titers, which probably is the same as the recently reported Cia28 [19].
T10256 17687-17689 PRP denotes We
T10257 17690-17698 VBD denotes detected
T10258 17699-17701 IN denotes on
T10259 17702-17712 NN denotes chromosome
T10260 17713-17715 CD denotes 13
T10261 17716-17717 DT denotes a
T10262 17718-17723 NN denotes locus
T10263 17724-17734 VBN denotes associated
T10264 17735-17739 IN denotes with
T10265 17740-17748 JJ denotes anti-CII
T10266 17749-17755 NNS denotes titers
T10267 17755-17757 , denotes ,
T10268 17757-17762 WDT denotes which
T10269 17772-17774 VBZ denotes is
T10270 17763-17771 RB denotes probably
T10271 17775-17778 DT denotes the
T10272 17779-17783 JJ denotes same
T10273 17784-17786 IN denotes as
T10274 17787-17790 DT denotes the
T10275 17809-17814 NN denotes Cia28
T10276 17791-17799 RB denotes recently
T10277 17800-17808 VBN denotes reported
T10278 17815-17816 -LRB- denotes [
T10279 17816-17818 CD denotes 19
T10280 17818-17819 -RRB- denotes ]
T10281 17819-17820 . denotes .
T5619 9680-9689 JJ denotes different
T5620 9690-9702 JJ denotes experimental
T5621 9710-9713 VBD denotes was
T5622 9724-9729 VBG denotes using
T5623 9730-9733 DT denotes the
T5624 9749-9753 NN denotes test
T5625 9734-9738 NNP denotes Mann
T5626 9739-9746 NNP denotes Whitney
T5627 9738-9739 HYPH denotes -
T5628 9747-9748 NNP denotes U
T5610 9624-9635 JJ denotes Statistical
T5611 9636-9644 NN denotes analysis
T5612 9644-9783 sentence denotes Statistical comparison between the different experimental groups was performed using the Mann-Whitney U test or Student's unpaired t test.
T5613 9645-9656 JJ denotes Statistical
T5614 9657-9667 NN denotes comparison
T5615 9714-9723 VBN denotes performed
T5616 9668-9675 IN denotes between
T5617 9676-9679 DT denotes the
T5618 9703-9709 NNS denotes groups
T531 0-14 NN denotes Identification
T10060 17377-17384 VB denotes exclude
T10061 17370-17373 MD denotes can
T10062 17373-17376 RB denotes not
T10063 17385-17389 IN denotes that
T10064 17411-17420 VBG denotes affecting
T10065 17390-17393 DT denotes the
T10066 17399-17403 NN denotes gene
T10067 17394-17398 JJ denotes same
T10068 17403-17404 -LRB- denotes (
T10069 17404-17405 AFX denotes s
T10070 17405-17406 -RRB- denotes )
T10071 17407-17410 VBP denotes are
T10072 17421-17425 PDT denotes both
T10073 17432-17438 NNS denotes traits
T10074 17426-17431 DT denotes these
T10075 17438-17439 . denotes .
R3 T535 T537 amod induced,loci
R4 T536 T535 punct -,induced
R5 T537 T533 pobj loci,of
R6 T538 T537 compound arthritis,loci
R9 T541 T539 pobj mice,in
R10 T542 T541 amod multiparous,mice
R11 T543 T541 amod female,mice
R13 T547 T549 amod induced,arthritis
R14 T548 T547 punct -,induced
R21 T556 T554 pobj models,of
R22 T557 T558 advmod most,commonly
R23 T558 T559 advmod commonly,used
R24 T559 T556 amod used,models
R25 T560 T556 amod autoimmune,models
R26 T561 T556 amod experimental,models
R36 T572 T577 advcl is,is
R37 T573 T574 npadvmod collagen,induced
R39 T575 T574 punct -,induced
R40 T576 T572 nsubj arthritis,is
R42 T579 T572 attr disease,is
R43 T580 T579 amod complex,disease
R44 T581 T579 amod polygenic,disease
R52 T589 T587 pobj genes,of
R53 T590 T589 amod major,genes
R54 T591 T592 npadvmod disease,controlling
R56 T593 T592 punct -,controlling
R59 T597 T601 advcl affects,identified
R60 T598 T599 amod rheumatoid,arthritis
R61 T599 T597 nsubj arthritis,affects
R62 T600 T597 advmod particularly,affects
R70 T609 T607 pobj study,in
R71 T610 T609 amod present,study
R73 T612 T601 dobj regions,identified
R74 T613 T612 amod genetic,regions
R78 T617 T619 amod induced,arthritis
R79 T618 T617 punct -,induced
R84 T623 T621 dobj mice,studying
R85 T624 T623 amod female,mice
R91 T630 T628 pobj N,between
R92 T631 T630 punct /,N
R96 T635 T627 parataxis haplotype,cross
R97 T636 T637 compound H,2q
R99 T638 T637 punct -,2q
R106 T647 T645 pobj study,in
R107 T648 T647 amod present,study
R109 T650 T644 dobj histories,had
R110 T651 T650 amod reproductive,histories
R113 T654 T650 relcl affect,histories
R114 T655 T654 aux did,affect
R115 T656 T654 neg not,affect
R116 T657 T654 advmod significantly,affect
R131 T674 T672 pobj mice,of
R132 T675 T674 amod female,mice
R136 T679 T677 pobj screening,in
R137 T680 T679 amod total,screening
R138 T681 T682 npadvmod genome,wide
R140 T683 T682 punct -,wide
R143 T686 T684 pobj markers,with
R144 T687 T686 compound microsatellite,markers
R148 T693 T691 dobj locus,found
R149 T694 T693 amod new,locus
R150 T695 T693 amod significant,locus
R151 T696 T697 amod quantitative,trait
R152 T697 T693 compound trait,locus
R155 T700 T698 dobj incidence,affecting
R156 T701 T700 compound arthritis,incidence
R175 T720 T718 pobj failure,with
R176 T721 T722 npadvmod locus,controlling
R177 T722 T720 amod controlling,failure
R178 T723 T720 compound pregnancy,failure
R183 T730 T727 nsubjpass locus,identified
R184 T731 T732 amod quantitative,trait
R185 T732 T730 compound trait,locus
R207 T756 T753 nsubjpass locus,identified
R208 T757 T758 advmod suggestively,significant
R209 T758 T756 amod significant,locus
R210 T759 T760 amod quantitative,trait
R211 T760 T756 compound trait,locus
R215 T764 T762 pobj titers,with
R216 T765 T764 nmod type,titers
R217 T766 T765 nummod II,type
R218 T767 T764 compound antibody,titers
R227 T778 T776 advcl control,indicates
R228 T779 T780 amod several,loci
R230 T781 T780 compound gene,loci
R234 T785 T783 pobj females,in
R235 T786 T785 amod multiparous,females
R239 T790 T778 conj coincides,control
R240 T791 T792 advmod at,least
R241 T792 T793 advmod least,one
R242 T793 T790 nsubj one,coincides
R243 T794 T793 prep of,one
R244 T795 T796 det these,loci
R245 T796 T794 pobj loci,of
R262 T1860 T1862 amod induced,arthritis
R263 T1861 T1860 punct -,induced
R274 T1872 T1849 advcl exist,are
R275 T1873 T1872 nsubj differences,exist
R276 T1874 T1873 prep in,differences
R277 T1875 T1876 det the,pattern
R279 T1877 T1876 compound disease,pattern
R292 T1892 T1890 acl are,fact
R293 T1893 T1892 nsubj women,are
R294 T1894 T1893 prep of,women
R295 T1895 T1896 amod reproductive,age
R296 T1896 T1894 pobj age,of
R313 T1915 T1910 ccomp exhibit,reported
R314 T1916 T1917 nummod 75,%
R315 T1917 T1915 nsubj %,exhibit
R316 T1918 T1917 prep of,%
R317 T1919 T1920 amod female,patients
R318 T1920 T1918 pobj patients,of
R319 T1921 T1922 punct (,females
R320 T1922 T1920 parataxis females,patients
R321 T1923 T1924 quantmod 23,31
R323 T1925 T1924 quantmod out,31
R324 T1926 T1924 quantmod of,31
R325 T1927 T1922 punct ),females
R326 T1928 T1920 prep with,patients
R327 T1929 T1928 pobj RA,with
R341 T1945 T1942 pobj hand,On
R342 T1946 T1945 amod other,hand
R348 T1952 T1943 ccomp postponed,suggested
R349 T1953 T1954 det the,onset
R350 T1954 T1952 nsubjpass onset,postponed
R351 T1955 T1954 prep of,onset
R352 T1956 T1955 pobj RA,of
R353 T1957 T1952 auxpass is,postponed
R366 T1972 T1964 advcl increased,reduced
R367 T1973 T1972 prep in,increased
R368 T1974 T1975 det the,year
R370 T1976 T1975 amod first,year
R371 T1977 T1975 advmod postpartum,year
R372 T1978 T1979 det the,chance
R373 T1979 T1972 nsubjpass chance,increased
R374 T1980 T1979 prep of,chance
R375 T1981 T1980 pobj onset,of
R376 T1982 T1972 auxpass is,increased
R378 T1984 T1964 parataxis 7,reduced
R379 T1985 T1984 nummod 6,7
R380 T1986 T1984 punct ",",7
R387 T1995 T1993 pobj study,of
R388 T1996 T1995 amod recent,study
R397 T2005 T1992 ccomp increase,indicate
R398 T2006 T2007 compound pregnancy,history
R399 T2007 T2005 nsubj history,increase
R400 T2008 T2005 aux does,increase
R401 T2009 T2005 neg not,increase
R415 T2024 T2026 nsubj models,are
R416 T2025 T2024 compound animal,models
R427 T2037 T2035 pobj diseases,in
R428 T2038 T2037 amod human,diseases
R435 T2047 T2042 dobj characteristics,shares
R436 T2048 T2046 cc and,immunological
R437 T2049 T2046 conj pathological,immunological
R446 T2058 T2056 pobj models,of
R447 T2059 T2060 advmod most,used
R448 T2060 T2058 amod used,models
R474 T2088 T2075 advcl lead,is
R475 T2089 T2090 amod different,species
R476 T2090 T2088 nsubj species,lead
R477 T2091 T2090 cc and,species
R478 T2092 T2093 amod different,variants
R479 T2093 T2090 conj variants,species
R480 T2094 T2090 prep of,species
R481 T2095 T2096 det the,disease
R482 T2096 T2094 pobj disease,of
R483 T2097 T2088 aux could,lead
R487 T2101 T2098 pobj predominance,to
R488 T2102 T2100 cc and,male
R489 T2103 T2100 conj female,male
R511 T2129 T2127 pobj influences,including
R512 T2130 T2128 punct ", ",genetic
R513 T2131 T2128 conj hormonal,genetic
R514 T2132 T2131 cc and,hormonal
R515 T2133 T2131 conj behavioral,hormonal
R530 T2150 T2147 conj models,RA
R531 T2151 T2150 amod different,models
R532 T2152 T2150 compound animal,models
R534 T2154 T2140 parataxis 9,are
R535 T2155 T2154 nummod 3,9
R536 T2156 T2154 punct ",",9
R553 T2175 T2161 parataxis 10,causes
R554 T2176 T2175 nummod 5,10
R555 T2177 T2175 punct ",",10
R559 T2181 T2161 advcl occurs,causes
R560 T2182 T2181 nsubj exacerbation,occurs
R561 T2183 T2181 advmod often,occurs
R564 T2186 T2181 parataxis 11,occurs
R565 T2187 T2186 nummod 7,11
R566 T2188 T2186 punct ",",11
R567 T2189 T2186 nummod 10,11
R568 T2190 T2186 punct ",",11
R572 T2195 T2197 amod induced,remission
R573 T2196 T2195 punct -,induced
R580 T2204 T2198 xcomp caused,appears
R581 T2205 T2204 auxpass be,caused
R590 T2214 T2198 advcl explained,appears
R591 T2215 T2216 det the,exacerbation
R593 T2217 T2216 compound postpartum,exacerbation
R594 T2218 T2214 aux can,explained
R595 T2219 T2214 auxpass be,explained
R598 T2222 T2220 pobj drop,by
R599 T2223 T2222 amod dramatic,drop
R610 T2234 T2232 pobj levels,with
R611 T2235 T2234 compound prolactin,levels
R617 T2242 T2251 csubjpass affects,studied
R618 T2243 T2244 det what,extent
R619 T2244 T2241 pcomp extent,To
R620 T2245 T2246 det the,history
R622 T2247 T2246 compound pregnancy,history
R623 T2248 T2249 punct (,parity
R624 T2249 T2246 parataxis parity,history
R625 T2250 T2249 punct ),parity
R651 T2279 T2276 relcl had,women
R652 T2280 T2278 prep of,many
R653 T2281 T2280 pobj which,of
R654 T2282 T2279 aux have,had
R664 T2292 T2288 xcomp mimic,is
R665 T2293 T2292 advmod also,mimic
R674 T2304 T2301 pobj paper,In
R675 T2305 T2304 amod present,paper
R681 T2311 T2309 relcl undergone,mice
R682 T2312 T2311 advmod previously,undergone
R683 T2313 T2311 aux had,undergone
R685 T2315 T2311 dobj study,undergone
R686 T2316 T2315 amod reproductive,study
R717 T2349 T2347 pobj mice,of
R718 T2350 T2349 amod female,mice
R720 T2352 T2349 parataxis months,mice
R721 T2353 T2352 nummod ten,months
R727 T2359 T2357 pobj backcross,of
R728 T2360 T2359 compound N2,backcross
R731 T2363 T2361 pobj N,between
R732 T2364 T2363 punct /,N
R735 T2367 T2363 conj B10.Q,N
R736 T2368 T2367 punct /,B10.Q
R744 T2376 T2374 dobj control,analyze
R745 T2377 T2376 amod genetic,control
R753 T2385 T2383 pobj history,with
R754 T2386 T2385 amod multiparous,history
R756 T2734 T2735 amod Inbred,mice
R757 T2735 T2739 nsubjpass mice,obtained
R758 T2736 T2737 compound NFR,N
R759 T2737 T2735 compound N,mice
R761 T2740 T2739 auxpass were,obtained
R762 T2741 T2739 advmod originally,obtained
R763 T2742 T2739 prep from,obtained
R764 T2743 T2744 det the,Institute
R765 T2744 T2742 pobj Institute,from
R766 T2745 T2744 compound National,Institute
R767 T2746 T2744 prep of,Institute
R768 T2747 T2746 pobj Health,of
R769 T2748 T2749 punct (,Bethesda
R770 T2749 T2744 parataxis Bethesda,Institute
R771 T2750 T2749 punct ", ",Bethesda
R772 T2751 T2749 npadvmod MD,Bethesda
R773 T2752 T2749 punct ", ",Bethesda
R774 T2753 T2749 npadvmod USA,Bethesda
R775 T2754 T2749 punct ),Bethesda
R776 T2755 T2739 cc and,obtained
R777 T2756 T2757 det the,mice
R778 T2757 T2759 nsubjpass mice,bought
R779 T2758 T2757 compound B10.Q,mice
R780 T2759 T2739 conj bought,obtained
R781 T2760 T2759 auxpass were,bought
R782 T2761 T2759 advmod originally,bought
R783 T2762 T2759 prep from,bought
R784 T2763 T2764 det The,Laboratory
R785 T2764 T2762 pobj Laboratory,from
R786 T2765 T2764 compound Jackson,Laboratory
R787 T2766 T2767 punct (,Harbor
R788 T2767 T2764 parataxis Harbor,Laboratory
R789 T2768 T2767 compound Bar,Harbor
R790 T2769 T2767 punct ", ",Harbor
R791 T2770 T2767 npadvmod ME,Harbor
R792 T2771 T2767 punct ", ",Harbor
R793 T2772 T2767 npadvmod USA,Harbor
R794 T2773 T2767 punct ),Harbor
R795 T2774 T2759 punct .,bought
R796 T2776 T2777 punct (,hybrids
R797 T2777 T2785 nsubjpass hybrids,bred
R798 T2778 T2779 nmod B10Q,F1
R799 T2779 T2777 compound F1,hybrids
R802 T2782 T2778 appos N,B10Q
R803 T2783 T2782 punct /,N
R805 T2786 T2777 cc and,hybrids
R806 T2787 T2788 punct (,mice
R807 T2788 T2777 conj mice,hybrids
R808 T2789 T2788 nmod B10.Q,mice
R809 T2790 T2789 punct ×,B10.Q
R810 T2791 T2792 compound NFR,N
R811 T2792 T2789 appos N,B10.Q
R813 T2794 T2789 punct ),B10.Q
R814 T2795 T2789 punct ×,B10.Q
R815 T2796 T2797 compound B10.Q,N2
R816 T2797 T2789 appos N2,B10.Q
R817 T2798 T2785 auxpass were,bred
R818 T2799 T2785 prep in,bred
R819 T2800 T2801 amod individual,cages
R820 T2801 T2799 pobj cages,in
R821 T2802 T2801 amod ventilated,cages
R822 T2803 T2785 prep in,bred
R823 T2804 T2805 det the,facility
R824 T2805 T2803 pobj facility,in
R825 T2806 T2807 compound BMC,Barrier
R826 T2807 T2805 compound Barrier,facility
R827 T2808 T2805 compound animal,facility
R828 T2809 T2803 cc and,in
R829 T2810 T2803 conj at,in
R830 T2811 T2812 det the,house
R831 T2812 T2810 pobj house,at
R832 T2813 T2812 compound animal,house
R833 T2814 T2812 prep of,house
R834 T2815 T2816 det the,Department
R835 T2816 T2814 pobj Department,of
R836 T2817 T2816 prep of,Department
R837 T2818 T2817 pobj Pathology,of
R838 T2819 T2816 punct ", ",Department
R839 T2820 T2821 compound Lund,University
R840 T2821 T2816 npadvmod University,Department
R841 T2822 T2816 punct ", ",Department
R842 T2823 T2816 npadvmod Sweden,Department
R843 T2824 T2785 punct .,bred
R844 T2826 T2827 det The,animals
R845 T2827 T2828 nsubjpass animals,fed
R846 T2829 T2828 auxpass were,fed
R847 T2830 T2831 advmod ad,libitum
R848 T2831 T2828 advmod libitum,fed
R849 T2832 T2828 prep with,fed
R850 T2833 T2834 amod standard,chow
R851 T2834 T2832 pobj chow,with
R852 T2835 T2834 compound rodent,chow
R853 T2836 T2837 punct (,AB
R854 T2837 T2834 parataxis AB,chow
R855 T2838 T2839 compound LAB,R36
R856 T2839 T2837 dep R36,AB
R858 T2841 T2837 punct ", ",AB
R859 T2842 T2843 amod irradiated,food
R860 T2843 T2837 dep food,AB
R862 T2845 T2843 prep for,food
R863 T2846 T2845 pobj rats,for
R864 T2847 T2846 cc and,rats
R865 T2848 T2846 conj mice,rats
R866 T2849 T2837 punct ;,AB
R867 T2850 T2837 compound Lactamin,AB
R868 T2851 T2837 punct ", ",AB
R869 T2852 T2837 npadvmod Stockholm,AB
R870 T2853 T2837 punct ", ",AB
R871 T2854 T2837 npadvmod Sweden,AB
R872 T2855 T2837 punct ),AB
R873 T2856 T2834 cc and,chow
R874 T2857 T2834 conj water,chow
R875 T2858 T2828 prep in,fed
R876 T2859 T2860 det a,photoperiod
R877 T2860 T2858 pobj photoperiod,in
R878 T2861 T2860 prep of,photoperiod
R879 T2862 T2863 nummod 12,hours
R880 T2863 T2861 pobj hours,of
R881 T2864 T2865 punct :,hours
R882 T2865 T2863 prep hours,hours
R883 T2866 T2865 nummod 12,hours
R884 T2867 T2863 appos light,hours
R885 T2868 T2869 punct :,dark
R886 T2869 T2867 prep dark,light
R887 T2870 T2828 punct .,fed
R888 T2872 T2873 det The,mice
R889 T2873 T2874 nsubj mice,had
R890 T2875 T2873 acl used,mice
R891 T2876 T2875 prep in,used
R892 T2877 T2878 det the,study
R893 T2878 T2876 pobj study,in
R894 T2879 T2878 amod present,study
R895 T2880 T2881 amod clean,protocols
R896 T2881 T2874 dobj protocols,had
R897 T2882 T2883 compound health,monitoring
R898 T2883 T2881 compound monitoring,protocols
R899 T2884 T2874 prep according,had
R900 T2885 T2884 prep to,according
R901 T2886 T2887 det the,Federation
R902 T2887 T2888 nmod Federation,Association
R903 T2888 T2894 compound Association,recommendations
R904 T2889 T2887 prep of,Federation
R905 T2890 T2891 compound European,Sciences
R906 T2891 T2889 pobj Sciences,of
R909 T2894 T2885 pobj recommendations,to
R910 T2895 T2874 punct .,had
R911 T2897 T2898 amod Ethical,permissions
R912 T2898 T2899 nsubj permissions,were
R913 T2900 T2899 attr M125,were
R914 T2901 T2900 punct -,M125
R915 T2902 T2900 nummod 04,M125
R916 T2903 T2904 punct (,transfer
R917 T2904 T2900 parataxis transfer,M125
R918 T2905 T2904 compound embryo,transfer
R919 T2906 T2904 punct ),transfer
R920 T2907 T2900 cc and,M125
R921 T2908 T2900 conj M290,M125
R922 T2909 T2908 punct -,M290
R923 T2910 T2908 nummod 03,M290
R924 T2911 T2912 punct (,reproduction
R925 T2912 T2908 parataxis reproduction,M290
R926 T2913 T2912 cc and,reproduction
R927 T2914 T2912 conj arthritis,reproduction
R928 T2915 T2912 punct ),reproduction
R929 T2916 T2899 punct .,were
R930 T3136 T3137 amod Experimental,design
R931 T3139 T3140 det A,total
R932 T3140 T3141 nsubjpass total,used
R933 T3142 T3140 prep of,total
R934 T3143 T3144 nummod 200,mice
R935 T3144 T3142 pobj mice,of
R936 T3145 T3144 amod female,mice
R937 T3146 T3144 punct (,mice
R938 T3147 T3148 advmod approximately,ten
R939 T3148 T3149 nummod ten,months
R940 T3149 T3150 npadvmod months,old
R941 T3150 T3144 amod old,mice
R942 T3151 T3144 punct ),mice
R943 T3152 T3144 prep of,mice
R944 T3153 T3154 compound N2,backcross
R945 T3154 T3152 pobj backcross,of
R946 T3155 T3156 punct (,B10.Q
R947 T3156 T3154 appos B10.Q,backcross
R948 T3157 T3156 punct ×,B10.Q
R949 T3158 T3159 compound NFR,N
R950 T3159 T3156 appos N,B10.Q
R951 T3160 T3159 punct /,N
R952 T3161 T3156 punct ),B10.Q
R953 T3162 T3156 punct ×,B10.Q
R954 T3163 T3156 appos B10.Q,B10.Q
R955 T3164 T3141 auxpass were,used
R956 T3165 T3141 punct .,used
R957 T3167 T3168 det The,mice
R958 T3168 T3169 nsubj mice,had
R959 T3170 T3169 advmod earlier,had
R960 T3171 T3169 prep undergone,had
R961 T3172 T3173 det a,study
R962 T3173 T3171 pobj study,undergone
R963 T3174 T3173 amod reproductive,study
R964 T3175 T3176 advmod where,had
R965 T3176 T3173 relcl had,study
R966 T3177 T3178 det each,animal
R967 T3178 T3176 nsubj animal,had
R968 T3179 T3180 nummod four,opportunities
R969 T3180 T3176 dobj opportunities,had
R970 T3181 T3180 compound mating,opportunities
R971 T3182 T3169 punct .,had
R972 T3184 T3185 advmod First,allowed
R973 T3186 T3185 punct ", ",allowed
R974 T3187 T3188 det the,mice
R975 T3188 T3185 nsubjpass mice,allowed
R976 T3189 T3188 amod female,mice
R977 T3190 T3185 auxpass were,allowed
R978 T3191 T3192 aux to,mate
R979 T3192 T3185 xcomp mate,allowed
R980 T3193 T3192 advmod twice,mate
R981 T3194 T3192 prep with,mate
R982 T3195 T3196 compound B10.RIII,males
R983 T3196 T3194 pobj males,with
R984 T3197 T3198 punct (,mating
R985 T3198 T3192 parataxis mating,mate
R986 T3199 T3198 amod allogeneic,mating
R987 T3200 T3198 prep by,mating
R988 T3201 T3200 pobj means,by
R989 T3202 T3201 prep of,means
R990 T3203 T3202 pobj MHC,of
R991 T3204 T3203 punct (,MHC
R992 T3205 T3206 amod major,complex
R993 T3206 T3203 appos complex,MHC
R994 T3207 T3206 compound histocompatibility,complex
R995 T3208 T3198 punct ),mating
R996 T3209 T3192 cc and,mate
R997 T3210 T3211 advmod finally,mate
R998 T3211 T3192 conj mate,mate
R999 T3212 T3211 aux to,mate
R1000 T3213 T3211 advmod twice,mate
R1001 T3214 T3211 prep with,mate
R1002 T3215 T3216 compound B10.Q,males
R1003 T3216 T3214 pobj males,with
R1004 T3217 T3218 punct (,mating
R1005 T3218 T3211 parataxis mating,mate
R1006 T3219 T3218 amod syngeneic,mating
R1007 T3220 T3218 prep by,mating
R1008 T3221 T3220 pobj means,by
R1009 T3222 T3221 prep of,means
R1010 T3223 T3222 pobj MHC,of
R1011 T3224 T3218 punct ),mating
R1012 T3225 T3185 punct .,allowed
R1013 T3227 T3228 prep After,induced
R1014 T3229 T3230 nummod four,pregnancies
R1015 T3230 T3227 pobj pregnancies,After
R1016 T3231 T3230 amod possible,pregnancies
R1017 T3232 T3228 nsubjpass CIA,induced
R1018 T3233 T3228 auxpass was,induced
R1019 T3234 T3228 prep to,induced
R1020 T3235 T3236 det the,mice
R1021 T3236 T3234 pobj mice,to
R1022 T3237 T3236 amod female,mice
R1023 T3238 T3228 punct .,induced
R1024 T3706 T3705 cc and,Induction
R1025 T3707 T3705 conj evaluation,Induction
R1026 T3708 T3705 prep of,Induction
R1027 T3709 T3708 pobj CIA,of
R1028 T3711 T3712 aux To,induce
R1029 T3712 T3713 advcl induce,immunized
R1030 T3714 T3712 dobj CIA,induce
R1031 T3715 T3713 punct ", ",immunized
R1032 T3716 T3717 det the,mice
R1033 T3717 T3713 nsubjpass mice,immunized
R1034 T3718 T3713 auxpass were,immunized
R1035 T3719 T3713 advmod subcutaneously,immunized
R1036 T3720 T3713 prep at,immunized
R1037 T3721 T3722 det the,base
R1038 T3722 T3720 pobj base,at
R1039 T3723 T3722 prep of,base
R1040 T3724 T3725 det the,tail
R1041 T3725 T3723 pobj tail,of
R1042 T3726 T3713 prep with,immunized
R1043 T3727 T3728 nummod 100,μg
R1044 T3728 T3729 compound μg,type
R1045 T3729 T3726 pobj type,with
R1046 T3730 T3729 compound rat,type
R1047 T3731 T3729 compound collagen,type
R1048 T3732 T3729 nummod II,type
R1049 T3733 T3734 punct (,CII
R1050 T3734 T3729 parataxis CII,type
R1051 T3735 T3734 punct ),CII
R1052 T3736 T3729 acl emulsified,type
R1053 T3737 T3736 prep in,emulsified
R1054 T3738 T3739 nummod 0.1,M
R1055 T3739 T3740 nmod M,acid
R1056 T3740 T3737 pobj acid,in
R1057 T3741 T3740 amod acetic,acid
R1058 T3742 T3740 acl combined,acid
R1059 T3743 T3742 prep with,combined
R1060 T3744 T3745 det an,amount
R1061 T3745 T3743 pobj amount,with
R1062 T3746 T3745 amod equal,amount
R1063 T3747 T3745 prep of,amount
R1064 T3748 T3749 amod complete,adjuvant
R1065 T3749 T3747 pobj adjuvant,of
R1066 T3750 T3749 poss Freud,adjuvant
R1067 T3751 T3750 case 's,Freud
R1068 T3752 T3753 punct (,Laboratories
R1069 T3753 T3749 parataxis Laboratories,adjuvant
R1070 T3754 T3753 compound Difco,Laboratories
R1071 T3755 T3753 punct ", ",Laboratories
R1072 T3756 T3753 npadvmod Detroit,Laboratories
R1073 T3757 T3753 punct ", ",Laboratories
R1074 T3758 T3753 npadvmod MI,Laboratories
R1075 T3759 T3753 punct ", ",Laboratories
R1076 T3760 T3753 npadvmod USA,Laboratories
R1077 T3761 T3753 punct ),Laboratories
R1078 T3762 T3713 punct .,immunized
R1079 T3764 T3765 det A,injection
R1080 T3765 T3767 nsubjpass injection,given
R1081 T3766 T3765 compound booster,injection
R1082 T3768 T3765 acl containing,injection
R1083 T3769 T3770 nummod 50,μg
R1084 T3770 T3771 compound μg,CII
R1085 T3771 T3768 dobj CII,containing
R1086 T3772 T3771 acl emulsified,CII
R1087 T3773 T3772 prep in,emulsified
R1088 T3774 T3775 nummod 0.1,M
R1089 T3775 T3776 nmod M,acid
R1090 T3776 T3773 pobj acid,in
R1091 T3777 T3776 amod acetic,acid
R1092 T3778 T3776 acl combined,acid
R1093 T3779 T3778 prep with,combined
R1094 T3780 T3781 det an,amount
R1095 T3781 T3779 pobj amount,with
R1096 T3782 T3781 amod equal,amount
R1097 T3783 T3781 prep of,amount
R1098 T3784 T3785 poss Freud,adjuvant
R1099 T3785 T3783 pobj adjuvant,of
R1100 T3786 T3784 case 's,Freud
R1101 T3787 T3785 amod incomplete,adjuvant
R1102 T3788 T3789 punct (,Laboratories
R1103 T3789 T3785 parataxis Laboratories,adjuvant
R1104 T3790 T3789 compound Difco,Laboratories
R1105 T3791 T3789 punct ),Laboratories
R1106 T3792 T3767 auxpass was,given
R1107 T3793 T3767 prep after,given
R1108 T3794 T3795 nummod 30,days
R1109 T3795 T3793 pobj days,after
R1110 T3796 T3767 punct .,given
R1111 T3798 T3799 det The,scoring
R1112 T3799 T3801 nsubj scoring,commenced
R1113 T3800 T3799 amod clinical,scoring
R1114 T3802 T3799 prep of,scoring
R1115 T3803 T3802 pobj arthritis,of
R1116 T3804 T3805 nummod 25,days
R1117 T3805 T3806 npadvmod days,after
R1118 T3806 T3801 prep after,commenced
R1119 T3807 T3808 det the,immunization
R1120 T3808 T3806 pobj immunization,after
R1121 T3809 T3808 amod first,immunization
R1122 T3810 T3801 punct .,commenced
R1123 T3812 T3813 nsubjpass Animals,examined
R1124 T3814 T3813 auxpass were,examined
R1125 T3815 T3813 prep for,examined
R1126 T3816 T3817 amod clinical,signs
R1127 T3817 T3815 pobj signs,for
R1128 T3818 T3817 prep of,signs
R1129 T3819 T3818 pobj CIA,of
R1130 T3820 T3821 nummod three,times
R1131 T3821 T3813 npadvmod times,examined
R1132 T3822 T3821 prep per,times
R1133 T3823 T3822 pobj week,per
R1134 T3824 T3813 cc and,examined
R1135 T3825 T3826 auxpass were,graded
R1136 T3826 T3813 conj graded,examined
R1137 T3827 T3826 prep on,graded
R1138 T3828 T3829 det a,scale
R1139 T3829 T3827 pobj scale,on
R1140 T3830 T3831 nummod 12,point
R1141 T3831 T3829 compound point,scale
R1143 T3833 T3813 punct .,examined
R1144 T3835 T3836 det The,index
R1145 T3836 T3838 nsubjpass index,assigned
R1146 T3837 T3836 compound arthritis,index
R1147 T3838 T3840 ccomp assigned,sign
R1148 T3839 T3838 auxpass was,assigned
R1149 T3841 T3838 prep to,assigned
R1150 T3842 T3843 det each,mouse
R1151 T3843 T3841 pobj mouse,to
R1152 T3844 T3838 advcl using,assigned
R1153 T3845 T3846 det the,criteria
R1154 T3846 T3844 dobj criteria,using
R1155 T3847 T3846 amod following,criteria
R1156 T3848 T3840 punct : ,sign
R1157 T3849 T3840 nsubj 0,sign
R1158 T3850 T3840 punct =,sign
R1159 T3851 T3840 det no,sign
R1160 T3852 T3840 amod visible,sign
R1161 T3853 T3840 prep of,sign
R1162 T3854 T3853 pobj arthritis,of
R1163 T3855 T3840 punct ", ",sign
R1164 T3856 T3857 nsubj 1,redness
R1165 T3857 T3840 conj redness,sign
R1166 T3858 T3857 punct =,redness
R1167 T3859 T3857 cc and,redness
R1168 T3860 T3857 conj swelling,redness
R1169 T3861 T3857 prep in,redness
R1170 T3862 T3863 det a,joint
R1171 T3863 T3861 pobj joint,in
R1172 T3864 T3863 amod single,joint
R1173 T3865 T3857 punct ", ",redness
R1174 T3866 T3867 nsubj 2,inflammation
R1175 T3867 T3857 conj inflammation,redness
R1176 T3868 T3867 punct =,inflammation
R1177 T3869 T3867 prep in,inflammation
R1178 T3870 T3871 amod multiple,joints
R1179 T3871 T3869 pobj joints,in
R1180 T3872 T3867 punct ", ",inflammation
R1181 T3873 T3867 cc and,inflammation
R1182 T3874 T3875 nsubj 3,inflammation
R1183 T3875 T3867 conj inflammation,inflammation
R1184 T3876 T3875 punct =,inflammation
R1185 T3877 T3875 amod severe,inflammation
R1186 T3878 T3875 prep in,inflammation
R1187 T3879 T3880 det the,paw
R1188 T3880 T3878 pobj paw,in
R1189 T3881 T3880 amod entire,paw
R1190 T3882 T3880 cc and,paw
R1191 T3883 T3882 punct /,and
R1192 T3884 T3882 cc or,and
R1193 T3885 T3880 conj anklebone,paw
R1194 T3886 T3840 punct .,sign
R1195 T3888 T3889 det Each,paw
R1196 T3889 T3890 nsubjpass paw,given
R1197 T3891 T3890 auxpass was,given
R1198 T3892 T3893 det the,scores
R1199 T3893 T3890 dobj scores,given
R1200 T3894 T3893 appos 0,scores
R1201 T3895 T3896 punct –,3
R1202 T3896 T3894 prep 3,0
R1203 T3897 T3890 punct ", ",given
R1204 T3898 T3890 prep with,given
R1205 T3899 T3900 det the,index
R1206 T3900 T3901 nsubj index,being
R1207 T3901 T3898 pcomp being,with
R1208 T3902 T3903 det the,sum
R1209 T3903 T3901 attr sum,being
R1210 T3904 T3903 prep of,sum
R1211 T3905 T3906 det all,paws
R1212 T3906 T3904 pobj paws,of
R1213 T3907 T3906 nummod four,paws
R1214 T3908 T3890 punct .,given
R1215 T3910 T3911 det The,trait
R1216 T3911 T3913 nsubj trait,is
R1217 T3912 T3911 compound severity,trait
R1218 T3914 T3915 det the,score
R1219 T3915 T3913 attr score,is
R1220 T3916 T3915 amod maximum,score
R1221 T3917 T3915 acl observed,score
R1222 T3918 T3917 prep in,observed
R1223 T3919 T3920 det each,female
R1224 T3920 T3918 pobj female,in
R1225 T3921 T3920 amod individual,female
R1226 T3922 T3913 punct .,is
R1227 T3924 T3925 det The,onset
R1228 T3925 T3926 nsubj onset,is
R1229 T3927 T3928 det the,number
R1230 T3928 T3926 attr number,is
R1231 T3929 T3928 prep of,number
R1232 T3930 T3929 pobj days,of
R1233 T3931 T3928 acl calculated,number
R1234 T3932 T3931 prep from,calculated
R1235 T3933 T3934 det the,immunization
R1236 T3934 T3932 pobj immunization,from
R1237 T3935 T3934 amod first,immunization
R1238 T3936 T3932 prep to,from
R1239 T3937 T3938 det the,signs
R1240 T3938 T3936 pobj signs,to
R1241 T3939 T3938 amod first,signs
R1242 T3940 T3938 amod clinical,signs
R1243 T3941 T3938 prep of,signs
R1244 T3942 T3941 pobj arthritis,of
R1245 T3943 T3931 advcl excluding,calculated
R1246 T3944 T3945 amod unaffected,animals
R1247 T3945 T3943 dobj animals,excluding
R1248 T3946 T3926 punct .,is
R1249 T4742 T4743 compound Microsatellite,genotyping
R1250 T4744 T4743 cc and,genotyping
R1251 T4745 T4746 compound linkage,analysis
R1252 T4746 T4743 conj analysis,genotyping
R1253 T4748 T4749 compound Tail,biopsies
R1254 T4749 T4750 nsubjpass biopsies,collected
R1255 T4751 T4750 auxpass were,collected
R1256 T4752 T4750 prep from,collected
R1257 T4753 T4754 det all,females
R1258 T4754 T4752 pobj females,from
R1259 T4755 T4754 compound N2,females
R1260 T4756 T4754 cc and,females
R1261 T4757 T4758 det the,generation
R1262 T4758 T4754 conj generation,females
R1263 T4759 T4758 compound F0,generation
R1264 T4760 T4750 punct .,collected
R1265 T4762 T4763 nsubjpass DNA,isolated
R1266 T4764 T4763 auxpass was,isolated
R1267 T4765 T4763 prep according,isolated
R1268 T4766 T4765 prep to,according
R1269 T4767 T4768 det a,protocol
R1270 T4768 T4766 pobj protocol,to
R1271 T4769 T4770 advmod previously,described
R1272 T4770 T4768 amod described,protocol
R1273 T4771 T4772 punct [,12
R1274 T4772 T4763 parataxis 12,isolated
R1275 T4773 T4772 punct ],12
R1276 T4774 T4763 punct .,isolated
R1277 T4776 T4777 prep After,covering
R1278 T4778 T4776 pobj screening,After
R1279 T4779 T4778 prep of,screening
R1280 T4780 T4781 amod parental,DNA
R1281 T4781 T4779 pobj DNA,of
R1282 T4782 T4778 prep with,screening
R1283 T4783 T4784 advmod approximately,450
R1284 T4784 T4785 nummod 450,markers
R1285 T4785 T4782 pobj markers,with
R1286 T4786 T4785 nmod mouse,markers
R1287 T4787 T4788 npadvmod fluorescence,labeled
R1288 T4788 T4785 amod labeled,markers
R1290 T4790 T4785 compound microsatellite,markers
R1291 T4791 T4792 punct (,INTERACTIVA
R1292 T4792 T4785 parataxis INTERACTIVA,markers
R1293 T4793 T4792 punct ", ",INTERACTIVA
R1294 T4794 T4792 npadvmod Ulm,INTERACTIVA
R1295 T4795 T4792 punct ", ",INTERACTIVA
R1296 T4796 T4792 npadvmod Germany,INTERACTIVA
R1297 T4797 T4792 punct ),INTERACTIVA
R1298 T4798 T4777 punct ", ",covering
R1299 T4799 T4800 nummod 125,markers
R1300 T4800 T4777 nsubjpass markers,covering
R1301 T4801 T4800 amod informative,markers
R1302 T4802 T4777 auxpass were,covering
R1303 T4803 T4777 aux selected,covering
R1304 T4804 T4805 det the,genome
R1305 T4805 T4777 dobj genome,covering
R1306 T4806 T4777 punct .,covering
R1307 T4808 T4809 compound Two,hundred
R1308 T4809 T4810 nummod hundred,mice
R1309 T4810 T4816 nsubjpass mice,genotyped
R1310 T4811 T4809 cc and,hundred
R1311 T4812 T4813 compound thirty,seven
R1312 T4813 T4809 conj seven,hundred
R1314 T4815 T4810 compound N2,mice
R1315 T4817 T4816 auxpass were,genotyped
R1316 T4818 T4816 prep with,genotyped
R1317 T4819 T4818 pobj markers,with
R1318 T4820 T4819 acl covering,markers
R1319 T4821 T4822 det all,chromosomes
R1320 T4822 T4820 dobj chromosomes,covering
R1321 T4823 T4822 prep except,chromosomes
R1322 T4824 T4823 prep for,except
R1323 T4825 T4826 det the,chromosome
R1324 T4826 T4824 pobj chromosome,for
R1325 T4827 T4826 compound Y,chromosome
R1326 T4828 T4816 punct .,genotyped
R1327 T4830 T4831 compound PCR,amplification
R1328 T4831 T4832 nsubjpass amplification,performed
R1329 T4833 T4831 prep for,amplification
R1330 T4834 T4835 det the,markers
R1331 T4835 T4833 pobj markers,for
R1332 T4836 T4832 auxpass was,performed
R1333 T4837 T4832 prep in,performed
R1334 T4838 T4839 det a,volume
R1335 T4839 T4837 pobj volume,in
R1336 T4840 T4839 amod final,volume
R1337 T4841 T4839 prep of,volume
R1338 T4842 T4843 nummod 10,μl
R1339 T4843 T4841 pobj μl,of
R1340 T4844 T4832 prep in,performed
R1341 T4845 T4846 det a,plate
R1342 T4846 T4844 pobj plate,in
R1343 T4847 T4848 nummod 96,well
R1344 T4848 T4846 compound well,plate
R1346 T4850 T4851 compound V,bottom
R1347 T4851 T4846 compound bottom,plate
R1349 T4853 T4846 compound microtiter,plate
R1350 T4854 T4832 advcl using,performed
R1351 T4855 T4856 nummod 20,ng
R1352 T4856 T4857 compound ng,DNA
R1353 T4857 T4854 dobj DNA,using
R1354 T4858 T4857 punct ", ",DNA
R1355 T4859 T4860 nummod 10,mM
R1356 T4860 T4861 compound mM,KCl
R1357 T4861 T4857 conj KCl,DNA
R1358 T4862 T4861 punct ", ",KCl
R1359 T4863 T4864 nummod 20,mM
R1360 T4864 T4865 compound mM,HCl
R1361 T4865 T4861 conj HCl,KCl
R1362 T4866 T4865 compound Tris,HCl
R1363 T4867 T4865 punct –,HCl
R1364 T4868 T4865 punct ", ",HCl
R1365 T4869 T4870 nummod 10,mM
R1366 T4870 T4871 nmod mM,2SO4
R1367 T4871 T4865 conj 2SO4,HCl
R1368 T4872 T4873 punct (,NH4
R1369 T4873 T4870 parataxis NH4,mM
R1370 T4874 T4873 punct ),NH4
R1371 T4875 T4871 punct ", ",2SO4
R1372 T4876 T4877 nummod 2,mM
R1373 T4877 T4878 compound mM,MgCl2
R1374 T4878 T4871 conj MgCl2,2SO4
R1375 T4879 T4878 punct ", ",MgCl2
R1376 T4880 T4881 nummod 0.1,%
R1377 T4881 T4882 compound %,X
R1378 T4882 T4878 conj X,MgCl2
R1379 T4883 T4882 compound Triton,X
R1380 T4884 T4882 punct -,X
R1381 T4885 T4882 nummod 100,X
R1382 T4886 T4882 punct ", ",X
R1383 T4887 T4882 npadvmod pH,X
R1384 T4888 T4887 nummod 8.8,pH
R1385 T4889 T4890 punct (,Inc.
R1386 T4890 T4882 parataxis Inc.,X
R1387 T4891 T4892 compound New,England
R1388 T4892 T4890 compound England,Inc.
R1389 T4893 T4890 compound BioLabs,Inc.
R1390 T4894 T4890 punct ", ",Inc.
R1391 T4895 T4890 npadvmod Ipswich,Inc.
R1392 T4896 T4890 punct ", ",Inc.
R1393 T4897 T4890 npadvmod MA,Inc.
R1394 T4898 T4890 punct ", ",Inc.
R1395 T4899 T4890 npadvmod USA,Inc.
R1396 T4900 T4890 punct ),Inc.
R1397 T4901 T4882 punct ", ",X
R1398 T4902 T4903 nummod 3,μM
R1399 T4903 T4904 nmod μM,primer
R1400 T4904 T4882 conj primer,X
R1401 T4905 T4906 punct (,pmol
R1402 T4906 T4903 parataxis pmol,μM
R1404 T4908 T4906 punct ),pmol
R1405 T4909 T4904 det each,primer
R1406 T4910 T4904 punct ", ",primer
R1407 T4911 T4912 nummod 2,mM
R1408 T4912 T4913 compound mM,dNTPs
R1409 T4913 T4904 conj dNTPs,primer
R1410 T4914 T4915 punct (,Biotechnologies
R1411 T4915 T4913 parataxis Biotechnologies,dNTPs
R1412 T4916 T4915 compound Advanced,Biotechnologies
R1413 T4917 T4915 punct ", ",Biotechnologies
R1414 T4918 T4915 npadvmod Epsom,Biotechnologies
R1415 T4919 T4915 punct ", ",Biotechnologies
R1416 T4920 T4915 npadvmod Surrey,Biotechnologies
R1417 T4921 T4915 punct ", ",Biotechnologies
R1418 T4922 T4915 npadvmod UK,Biotechnologies
R1419 T4923 T4915 punct ),Biotechnologies
R1420 T4924 T4913 cc and,dNTPs
R1421 T4925 T4926 nummod 0.25,U
R1422 T4926 T4927 compound U,Polymerase
R1423 T4927 T4913 conj Polymerase,dNTPs
R1424 T4928 T4927 compound Taq,Polymerase
R1425 T4929 T4927 compound DNA,Polymerase
R1426 T4930 T4931 punct (,Inc.
R1427 T4931 T4927 parataxis Inc.,Polymerase
R1428 T4932 T4933 compound New,England
R1429 T4933 T4931 compound England,Inc.
R1430 T4934 T4931 compound BioLabs,Inc.
R1431 T4935 T4931 punct ),Inc.
R1432 T4936 T4832 punct .,performed
R1433 T4938 T4939 det The,program
R1434 T4939 T4941 nsubjpass program,used
R1435 T4940 T4939 amod following,program
R1436 T4942 T4941 auxpass was,used
R1437 T4943 T4944 aux to,amplify
R1438 T4944 T4941 advcl amplify,used
R1439 T4945 T4946 det the,DNA
R1440 T4946 T4944 dobj DNA,amplify
R1441 T4947 T4941 punct : ,used
R1442 T4948 T4941 dep denaturation,used
R1443 T4949 T4948 prep at,denaturation
R1444 T4950 T4951 nummod 95,°C
R1445 T4951 T4949 pobj °C,at
R1446 T4952 T4948 prep for,denaturation
R1447 T4953 T4954 nummod 3,minutes
R1448 T4954 T4952 pobj minutes,for
R1449 T4955 T4948 punct ", ",denaturation
R1450 T4956 T4948 conj annealing,denaturation
R1451 T4957 T4956 prep at,annealing
R1452 T4958 T4959 nummod 56,°C
R1453 T4959 T4957 pobj °C,at
R1454 T4960 T4956 prep for,annealing
R1455 T4961 T4962 nummod 45,seconds
R1456 T4962 T4960 pobj seconds,for
R1457 T4963 T4956 punct ", ",annealing
R1458 T4964 T4956 conj polymerization,annealing
R1459 T4965 T4964 prep at,polymerization
R1460 T4966 T4967 nummod 72,°C
R1461 T4967 T4965 pobj °C,at
R1462 T4968 T4964 prep for,polymerization
R1463 T4969 T4970 nummod 1,minute
R1464 T4970 T4968 pobj minute,for
R1465 T4971 T4964 punct ", ",polymerization
R1466 T4972 T4973 nummod 30,cycles
R1467 T4973 T4964 conj cycles,polymerization
R1468 T4974 T4973 prep of,cycles
R1469 T4975 T4976 nummod 95,°C
R1470 T4976 T4974 pobj °C,of
R1471 T4977 T4976 prep for,°C
R1472 T4978 T4979 nummod 30,seconds
R1473 T4979 T4977 pobj seconds,for
R1474 T4980 T4976 punct ", ",°C
R1475 T4981 T4982 nummod 56,°C
R1476 T4982 T4976 conj °C,°C
R1477 T4983 T4982 prep for,°C
R1478 T4984 T4985 nummod 45,seconds
R1479 T4985 T4983 pobj seconds,for
R1480 T4986 T4982 cc and,°C
R1481 T4987 T4988 nummod 72,°C
R1482 T4988 T4982 conj °C,°C
R1483 T4989 T4988 prep for,°C
R1484 T4990 T4991 nummod 1,minute
R1485 T4991 T4989 pobj minute,for
R1486 T4992 T4973 punct ", ",cycles
R1487 T4993 T4973 cc and,cycles
R1488 T4994 T4995 det a,step
R1489 T4995 T4973 conj step,cycles
R1490 T4996 T4995 amod final,step
R1491 T4997 T4995 compound extension,step
R1492 T4998 T4995 prep of,step
R1493 T4999 T5000 nummod 7,minutes
R1494 T5000 T4998 pobj minutes,of
R1495 T5001 T5000 prep at,minutes
R1496 T5002 T5003 nummod 72,°C
R1497 T5003 T5001 pobj °C,at
R1498 T5004 T4941 punct .,used
R1499 T5006 T5007 det The,products
R1500 T5007 T5009 nsubjpass products,analyzed
R1501 T5008 T5007 compound PCR,products
R1502 T5010 T5009 auxpass were,analyzed
R1503 T5011 T5009 prep on,analyzed
R1504 T5012 T5013 det a,MegaBACE
R1505 T5013 T5011 pobj MegaBACE,on
R1506 T5014 T5013 punct ™,MegaBACE
R1507 T5015 T5013 nummod 1000,MegaBACE
R1508 T5016 T5017 punct (,Inc
R1509 T5017 T5013 parataxis Inc,MegaBACE
R1510 T5018 T5017 compound Amersham,Inc
R1511 T5019 T5017 compound Pharmacia,Inc
R1512 T5020 T5017 compound Biotech,Inc
R1513 T5021 T5017 npadvmod Piscataway,Inc
R1514 T5022 T5017 punct ", ",Inc
R1515 T5023 T5017 npadvmod NJ,Inc
R1516 T5024 T5017 punct ", ",Inc
R1517 T5025 T5017 npadvmod USA,Inc
R1518 T5026 T5017 punct ),Inc
R1519 T5027 T5009 prep according,analyzed
R1520 T5028 T5027 prep to,according
R1521 T5029 T5030 det the,manufacturer
R1522 T5030 T5031 poss manufacturer,protocol
R1523 T5031 T5028 pobj protocol,to
R1524 T5032 T5030 case 's,manufacturer
R1525 T5033 T5009 punct .,analyzed
R1526 T5035 T5036 nsubjpass Data,analyzed
R1527 T5037 T5036 auxpass were,analyzed
R1528 T5038 T5036 prep with,analyzed
R1529 T5039 T5040 amod Genetic,Profiler
R1530 T5040 T5038 pobj Profiler,with
R1531 T5041 T5040 nummod 1.1,Profiler
R1532 T5042 T5043 punct (,Inc
R1533 T5043 T5040 parataxis Inc,Profiler
R1534 T5044 T5043 compound Amersham,Inc
R1535 T5045 T5043 compound Pharmacia,Inc
R1536 T5046 T5043 compound Biotech,Inc
R1537 T5047 T5043 punct ),Inc
R1538 T5048 T5036 punct .,analyzed
R1539 T5050 T5051 nmod Map,QTXb20
R1540 T5051 T5053 nmod QTXb20,software
R1541 T5052 T5051 nmod Manager,QTXb20
R1542 T5053 T5055 nsubjpass software,used
R1543 T5054 T5053 amod free,software
R1544 T5056 T5057 punct [,13
R1545 T5057 T5053 parataxis 13,software
R1546 T5058 T5057 punct ],13
R1547 T5059 T5055 auxpass was,used
R1548 T5060 T5061 aux to,perform
R1549 T5061 T5055 advcl perform,used
R1550 T5062 T5063 compound linkage,analysis
R1551 T5063 T5061 dobj analysis,perform
R1552 T5064 T5063 cc and,analysis
R1553 T5065 T5066 det the,test
R1554 T5066 T5063 conj test,analysis
R1555 T5067 T5066 compound permutation,test
R1556 T5068 T5055 punct .,used
R1557 T5070 T5071 nummod Ninety,percent
R1558 T5071 T5072 nsubj percent,was
R1559 T5073 T5071 prep of,percent
R1560 T5074 T5075 det the,genome
R1561 T5075 T5073 pobj genome,of
R1562 T5076 T5075 compound mouse,genome
R1563 T5077 T5072 prep within,was
R1564 T5078 T5079 det a,distance
R1565 T5079 T5077 pobj distance,within
R1566 T5080 T5081 nummod 20,cM
R1567 T5081 T5079 compound cM,distance
R1568 T5082 T5079 compound intermarker,distance
R1569 T5083 T5072 punct .,was
R1570 T5085 T5086 det The,map
R1571 T5086 T5088 nsubjpass map,generated
R1572 T5087 T5086 compound marker,map
R1573 T5089 T5088 auxpass was,generated
R1574 T5090 T5088 advcl using,generated
R1575 T5091 T5092 det the,function
R1576 T5092 T5090 dobj function,using
R1577 T5093 T5092 compound Kosambis,function
R1578 T5094 T5092 compound map,function
R1579 T5095 T5088 cc and,generated
R1580 T5096 T5097 nummod "1,000",permutations
R1581 T5097 T5098 nsubjpass permutations,performed
R1582 T5098 T5088 conj performed,generated
R1583 T5099 T5098 auxpass were,performed
R1584 T5100 T5098 prep for,performed
R1585 T5101 T5102 det every,phenotype
R1586 T5102 T5100 pobj phenotype,for
R1587 T5103 T5104 punct (,0.05
R1588 T5104 T5098 parataxis 0.05,performed
R1589 T5105 T5104 nsubj P,0.05
R1590 T5106 T5104 punct <,0.05
R1591 T5107 T5104 punct ),0.05
R1592 T5108 T5098 punct .,performed
R1593 T5110 T5111 det The,tests
R1594 T5111 T5113 nsubjpass tests,carried
R1595 T5112 T5111 compound permutation,tests
R1596 T5114 T5113 auxpass were,carried
R1597 T5115 T5113 prt out,carried
R1598 T5116 T5117 aux to,establish
R1599 T5117 T5113 advcl establish,carried
R1600 T5118 T5119 amod empirical,significance
R1601 T5119 T5120 compound significance,thresholds
R1602 T5120 T5117 dobj thresholds,establish
R1603 T5121 T5117 prep for,establish
R1604 T5122 T5123 det the,interactions
R1605 T5123 T5121 pobj interactions,for
R1606 T5124 T5113 punct .,carried
R1607 T5126 T5127 det A,threshold
R1608 T5127 T5128 nsubjpass threshold,considered
R1609 T5129 T5127 amod equal,threshold
R1610 T5130 T5129 prep to,equal
R1611 T5131 T5129 cc or,equal
R1612 T5132 T5133 prep above,percentile
R1613 T5133 T5129 conj percentile,equal
R1614 T5134 T5133 det the,percentile
R1615 T5135 T5133 amod 37th,percentile
R1616 T5136 T5137 punct (,0.63
R1617 T5137 T5127 parataxis 0.63,threshold
R1618 T5138 T5137 nsubj P,0.63
R1619 T5139 T5137 punct =,0.63
R1620 T5140 T5137 punct ),0.63
R1621 T5141 T5128 auxpass was,considered
R1622 T5142 T5143 advmod suggestively,significant
R1623 T5143 T5128 oprd significant,considered
R1624 T5144 T5128 punct ", ",considered
R1625 T5145 T5128 cc and,considered
R1626 T5146 T5147 det the,level
R1627 T5147 T5148 nsubjpass level,set
R1628 T5148 T5128 conj set,considered
R1629 T5149 T5147 prep for,level
R1630 T5150 T5151 det the,threshold
R1631 T5151 T5149 pobj threshold,for
R1633 T5153 T5148 auxpass was,set
R1634 T5154 T5148 prep to,set
R1635 T5155 T5156 det the,percentile
R1636 T5156 T5154 pobj percentile,to
R1637 T5157 T5156 amod 95th,percentile
R1638 T5158 T5159 punct (,0.05
R1639 T5159 T5148 parataxis 0.05,set
R1640 T5160 T5159 nsubj P,0.05
R1641 T5161 T5159 punct =,0.05
R1642 T5162 T5159 punct ),0.05
R1643 T5163 T5148 punct .,set
R1644 T5165 T5166 amod Interval,mapping
R1645 T5166 T5167 nsubjpass mapping,made
R1646 T5168 T5167 auxpass was,made
R1647 T5169 T5167 prep with,made
R1648 T5170 T5171 det a,increase
R1649 T5171 T5169 pobj increase,with
R1650 T5172 T5173 nummod 2,cM
R1651 T5173 T5171 compound cM,increase
R1652 T5174 T5167 prep under,made
R1653 T5175 T5176 det the,model
R1654 T5176 T5174 pobj model,under
R1655 T5177 T5176 amod additive,model
R1656 T5178 T5176 compound regression,model
R1657 T5179 T5167 prep in,made
R1658 T5180 T5179 pobj order,in
R1659 T5181 T5182 aux to,calculate
R1660 T5182 T5180 acl calculate,order
R1661 T5183 T5184 det the,statistics
R1662 T5184 T5182 dobj statistics,calculate
R1663 T5185 T5184 compound test,statistics
R1664 T5186 T5167 punct .,made
R1665 T5443 T5444 npadvmod Enzyme,linked
R1666 T5444 T5446 amod linked,assay
R1667 T5445 T5444 punct -,linked
R1668 T5447 T5446 compound immunosorbent,assay
R1669 T5449 T5450 det The,mice
R1670 T5450 T5453 nsubjpass mice,sacrificed
R1671 T5451 T5450 amod adult,mice
R1672 T5452 T5450 amod female,mice
R1673 T5454 T5453 auxpass were,sacrificed
R1674 T5455 T5453 prep at,sacrificed
R1675 T5456 T5457 nummod 15,months
R1676 T5457 T5455 pobj months,at
R1677 T5458 T5457 prep of,months
R1678 T5459 T5458 pobj age,of
R1679 T5460 T5453 cc and,sacrificed
R1680 T5461 T5462 nsubjpass sera,collected
R1681 T5462 T5453 conj collected,sacrificed
R1682 T5463 T5462 auxpass were,collected
R1683 T5464 T5462 punct .,collected
R1684 T5466 T5467 amod Anti-CII,titers
R1685 T5467 T5469 nsubjpass titers,analyzed
R1686 T5468 T5467 compound antibody,titers
R1687 T5470 T5467 prep in,titers
R1688 T5471 T5470 pobj sera,in
R1689 T5472 T5469 auxpass were,analyzed
R1690 T5473 T5469 prep by,analyzed
R1691 T5474 T5475 det a,technique
R1692 T5475 T5473 pobj technique,by
R1693 T5476 T5477 compound sandwich,ELISA
R1694 T5477 T5475 compound ELISA,technique
R1695 T5478 T5479 punct [,14
R1696 T5479 T5469 parataxis 14,analyzed
R1697 T5480 T5479 punct ],14
R1698 T5481 T5469 punct .,analyzed
R1699 T5483 T5484 prep In,coupled
R1700 T5485 T5483 amod brief,In
R1701 T5486 T5484 punct ", ",coupled
R1702 T5487 T5484 nsubjpass CII,coupled
R1703 T5488 T5489 punct (,μg
R1704 T5489 T5487 parataxis μg,CII
R1705 T5490 T5489 nummod 10,μg
R1706 T5491 T5492 punct /,ml
R1707 T5492 T5489 prep ml,μg
R1708 T5493 T5489 punct ),μg
R1709 T5494 T5484 auxpass was,coupled
R1710 T5495 T5484 prep to,coupled
R1711 T5496 T5497 compound immunosorbent,plates
R1712 T5497 T5495 pobj plates,to
R1713 T5498 T5484 advmod overnight,coupled
R1714 T5499 T5484 prep at,coupled
R1715 T5500 T5501 nummod 4,°C
R1716 T5501 T5499 pobj °C,at
R1717 T5502 T5484 punct .,coupled
R1718 T5504 T5505 amod Bovine,albumin
R1719 T5505 T5507 nsubjpass albumin,used
R1720 T5506 T5505 compound serum,albumin
R1721 T5508 T5509 punct (,Chemical
R1722 T5509 T5505 parataxis Chemical,albumin
R1723 T5510 T5509 compound Sigma,Chemical
R1724 T5511 T5512 compound St,Louis
R1725 T5512 T5509 npadvmod Louis,Chemical
R1726 T5513 T5509 punct ", ",Chemical
R1727 T5514 T5509 npadvmod MO,Chemical
R1728 T5515 T5509 punct ", ",Chemical
R1729 T5516 T5509 npadvmod USA,Chemical
R1730 T5517 T5509 punct ),Chemical
R1731 T5518 T5507 auxpass was,used
R1732 T5519 T5507 prep for,used
R1733 T5520 T5519 pobj blocking,for
R1734 T5521 T5507 punct ", ",used
R1735 T5522 T5507 cc and,used
R1736 T5523 T5524 advmod thereafter,added
R1737 T5524 T5507 conj added,used
R1738 T5525 T5526 amod different,dilutions
R1848 T5938 T5933 punct ),Table
R1739 T5526 T5524 nsubjpass dilutions,added
R1740 T5527 T5526 prep of,dilutions
R1741 T5528 T5529 compound control,sera
R1742 T5529 T5527 pobj sera,of
R1743 T5530 T5531 punct (,antibodies
R1744 T5531 T5529 parataxis antibodies,sera
R1748 T5535 T5531 punct ),antibodies
R1749 T5536 T5529 punct ", ",sera
R1750 T5537 T5538 compound test,sera
R1751 T5538 T5529 conj sera,sera
R1752 T5539 T5538 punct ", ",sera
R1753 T5540 T5538 cc and,sera
R1754 T5541 T5542 amod positive,controls
R1755 T5542 T5538 conj controls,sera
R1758 T5545 T5524 auxpass were,added
R1759 T5546 T5524 punct .,added
R1760 T5548 T5549 det The,presence
R1761 T5549 T5550 nsubjpass presence,visualized
R1762 T5551 T5549 prep of,presence
R1763 T5552 T5553 npadvmod CII,specific
R1764 T5553 T5555 amod specific,IgG
R1765 T5554 T5553 punct -,specific
R1766 T5555 T5551 pobj IgG,of
R1767 T5556 T5550 auxpass was,visualized
R1768 T5557 T5550 prep by,visualized
R1769 T5558 T5557 pobj means,by
R1770 T5559 T5558 prep of,means
R1771 T5560 T5561 npadvmod peroxidase,conjugated
R1772 T5561 T5563 amod conjugated,IgG
R1773 T5562 T5561 punct -,conjugated
R1774 T5563 T5559 pobj IgG,of
R1775 T5564 T5563 nmod goat,IgG
R1776 T5565 T5563 amod antimouse,IgG
R1777 T5566 T5550 punct .,visualized
R1801 T5888 T5889 nmod NFR,N
R1802 T5889 T5891 nmod N,mice
R1803 T5890 T5889 punct /,N
R1804 T5891 T5893 nsubj mice,show
R1805 T5892 T5891 amod female,mice
R1806 T5894 T5895 amod delayed,onset
R1807 T5895 T5893 dobj onset,show
R1808 T5896 T5895 cc and,onset
R1809 T5897 T5898 amod lower,incidence
R1810 T5898 T5895 conj incidence,onset
R1811 T5899 T5895 prep of,onset
R1812 T5900 T5899 pobj CIA,of
R1813 T5901 T5893 prep compared,show
R1814 T5902 T5901 prep with,compared
R1815 T5903 T5904 compound B10.Q,females
R1816 T5904 T5902 pobj females,with
R1817 T5906 T5907 det The,onset
R1818 T5907 T5908 nsubjpass onset,delayed
R1819 T5909 T5907 prep of,onset
R1820 T5910 T5911 det the,disease
R1821 T5911 T5909 pobj disease,of
R1822 T5912 T5908 auxpass was,delayed
R1823 T5913 T5908 advmod significantly,delayed
R1824 T5914 T5908 prep in,delayed
R1825 T5915 T5916 compound NFR,N
R1826 T5916 T5918 compound N,mice
R1827 T5917 T5916 punct /,N
R1828 T5918 T5914 pobj mice,in
R1829 T5919 T5908 punct ", ",delayed
R1830 T5920 T5921 dep which,resulted
R1831 T5921 T5908 advcl resulted,delayed
R1832 T5922 T5921 prep in,resulted
R1833 T5923 T5924 amod lower,incidence
R1834 T5924 T5922 pobj incidence,in
R1835 T5925 T5921 prep in,resulted
R1836 T5926 T5927 det the,phase
R1837 T5927 T5925 pobj phase,in
R1838 T5928 T5927 amod initial,phase
R1839 T5929 T5927 prep of,phase
R1840 T5930 T5931 det the,disease
R1841 T5931 T5929 pobj disease,of
R1842 T5932 T5933 punct (,Table
R1843 T5933 T5921 parataxis Table,resulted
R1844 T5934 T5933 nummod 1,Table
R1845 T5935 T5933 cc and,Table
R1846 T5936 T5933 conj Figure,Table
R1847 T5937 T5936 nummod 1,Figure
R1849 T5939 T5908 punct .,delayed
R1850 T5941 T5942 det The,appearance
R1851 T5942 T5943 nsubj appearance,was
R1852 T5944 T5942 prep of,appearance
R1853 T5945 T5946 det the,arthritis
R1854 T5946 T5944 pobj arthritis,of
R1855 T5947 T5948 advmod slightly,different
R1856 T5948 T5943 acomp different,was
R1857 T5949 T5943 prep between,was
R1858 T5950 T5951 det the,strains
R1859 T5951 T5949 pobj strains,between
R1860 T5952 T5951 nummod two,strains
R1861 T5953 T5943 punct ", ",was
R1862 T5954 T5955 compound NFR,N
R1863 T5955 T5957 compound N,mice
R1864 T5956 T5955 punct /,N
R1865 T5957 T5958 nsubj mice,showing
R1866 T5958 T5943 advcl showing,was
R1867 T5959 T5960 det a,frequency
R1868 T5960 T5958 dobj frequency,showing
R1869 T5961 T5960 amod higher,frequency
R1870 T5962 T5960 prep of,frequency
R1871 T5963 T5962 pobj swelling,of
R1872 T5964 T5963 prep of,swelling
R1873 T5965 T5966 det the,paw
R1874 T5966 T5964 pobj paw,of
R1875 T5967 T5966 amod entire,paw
R1876 T5968 T5960 prep than,frequency
R1877 T5969 T5970 compound B10.Q,mice
R1878 T5970 T5968 pobj mice,than
R1879 T5971 T5943 punct .,was
R1880 T5973 T5974 advmod Later,were
R1881 T5975 T5973 prep in,Later
R1882 T5976 T5977 det the,course
R1883 T5977 T5975 pobj course,in
R1884 T5978 T5977 compound disease,course
R1885 T5979 T5980 det the,differences
R1886 T5980 T5974 nsubj differences,were
R1887 T5981 T5980 prep in,differences
R1888 T5982 T5983 compound CIA,frequency
R1889 T5983 T5981 pobj frequency,in
R1890 T5984 T5983 cc and,frequency
R1891 T5985 T5983 conj severity,frequency
R1892 T5986 T5983 prep between,frequency
R1893 T5987 T5988 det the,strains
R1894 T5988 T5986 pobj strains,between
R1895 T5989 T5990 advmod less,obvious
R1896 T5990 T5974 acomp obvious,were
R1897 T5991 T5974 punct .,were
R1898 T5993 T5994 advmod However,differed
R1899 T5995 T5994 punct ", ",differed
R1900 T5996 T5997 det the,titers
R1901 T5997 T5994 nsubj titers,differed
R1902 T5998 T5997 amod anti-CII,titers
R1903 T5999 T6000 nummod 100,days
R1904 T6000 T6001 npadvmod days,after
R1905 T6001 T5994 prep after,differed
R1906 T6002 T6003 amod primary,immunization
R1907 T6003 T6001 pobj immunization,after
R1908 T6004 T6001 punct (,after
R1909 T6005 T6001 cc and,after
R1910 T6006 T6007 nummod 70,days
R1911 T6007 T6008 npadvmod days,after
R1912 T6008 T6001 conj after,after
R1913 T6009 T6010 det the,booster
R1914 T6010 T6008 pobj booster,after
R1915 T6011 T5994 punct ),differed
R1916 T6012 T5994 advmod significantly,differed
R1917 T6013 T5994 prep between,differed
R1918 T6014 T6015 nmod NFR,N
R1919 T6015 T6017 nmod N,mice
R1920 T6016 T6015 punct /,N
R1921 T6017 T6013 pobj mice,between
R1922 T6018 T6015 cc and,N
R1923 T6019 T6015 conj B10.Q,N
R1924 T6020 T6017 amod female,mice
R1925 T6021 T6022 punct (,see
R1926 T6022 T5994 parataxis see,differed
R1927 T6023 T6022 dobj Table,see
R1928 T6024 T6023 nummod 1,Table
R1929 T6025 T6022 punct ),see
R1930 T6026 T5994 punct .,differed
R1931 T6416 T6417 compound Pregnancy,history
R1932 T6417 T6418 nsubj history,affect
R1933 T6419 T6418 aux does,affect
R1934 T6420 T6418 neg not,affect
R1935 T6421 T6418 advmod significantly,affect
R1936 T6422 T6418 dobj incidence,affect
R1937 T6423 T6422 cc or,incidence
R1938 T6424 T6422 conj severity,incidence
R1939 T6425 T6422 prep of,incidence
R1940 T6426 T6425 pobj CIA,of
R1941 T6427 T6418 prep in,affect
R1942 T6428 T6429 amod female,mice
R1943 T6429 T6427 pobj mice,in
R1944 T6430 T6429 prep of,mice
R1945 T6431 T6432 amod mixed,background
R1946 T6432 T6430 pobj background,of
R1947 T6433 T6432 amod genetic,background
R1948 T6435 T6436 nsubj Table,presents
R1949 T6437 T6435 nummod 2,Table
R1950 T6438 T6439 det the,results
R1951 T6439 T6436 dobj results,presents
R1952 T6440 T6439 prep of,results
R1953 T6441 T6442 amod arthritic,incidence
R1954 T6442 T6440 pobj incidence,of
R1955 T6443 T6442 punct ", ",incidence
R1956 T6444 T6445 compound arthritis,onset
R1957 T6445 T6442 conj onset,incidence
R1958 T6446 T6445 cc and,onset
R1959 T6447 T6448 amod maximum,score
R1960 T6448 T6445 conj score,onset
R1961 T6449 T6448 amod arthritic,score
R1962 T6450 T6442 prep for,incidence
R1963 T6451 T6452 det the,mice
R1964 T6452 T6450 pobj mice,for
R1965 T6453 T6452 amod female,mice
R1966 T6454 T6452 prep of,mice
R1967 T6455 T6456 det the,generation
R1968 T6456 T6454 pobj generation,of
R1969 T6457 T6456 compound N2,generation
R1970 T6458 T6452 punct ", ",mice
R1971 T6459 T6460 punct (,N
R1972 T6460 T6452 appos N,mice
R1973 T6461 T6460 compound NFR,N
R1974 T6462 T6460 punct /,N
R1975 T6463 T6460 punct ×,N
R1976 T6464 T6460 appos B10.Q,N
R1977 T6465 T6460 punct ),N
R1978 T6466 T6460 punct ×,N
R1979 T6467 T6460 appos B10.Q,N
R1980 T6468 T6452 punct ", ",mice
R1981 T6469 T6452 acl grouped,mice
R1982 T6470 T6469 prep according,grouped
R1983 T6471 T6470 prep to,according
R1984 T6472 T6473 det the,number
R1985 T6473 T6471 pobj number,to
R1986 T6474 T6473 prep of,number
R1987 T6475 T6474 pobj pregnancies,of
R1988 T6476 T6477 nsubj they,experienced
R1989 T6477 T6473 advcl experienced,number
R1990 T6478 T6477 aux had,experienced
R1991 T6479 T6480 amod prior,to
R1992 T6480 T6477 prep to,experienced
R1993 T6481 T6480 pobj immunization,to
R1994 T6482 T6481 prep with,immunization
R1995 T6483 T6482 pobj CII,with
R1996 T6484 T6436 punct .,presents
R1997 T6486 T6487 expl There,was
R1998 T6488 T6489 det no,difference
R1999 T6489 T6487 attr difference,was
R2000 T6490 T6489 amod significant,difference
R2001 T6491 T6489 prep in,difference
R2002 T6492 T6493 det the,incidence
R2003 T6493 T6491 pobj incidence,in
R2004 T6494 T6493 cc or,incidence
R2005 T6495 T6493 conj severity,incidence
R2006 T6496 T6493 prep of,incidence
R2007 T6497 T6496 pobj arthritis,of
R2008 T6498 T6487 prep depending,was
R2009 T6499 T6498 prep on,depending
R2010 T6500 T6501 det the,number
R2011 T6501 T6499 pobj number,on
R2012 T6502 T6501 prep of,number
R2013 T6503 T6502 pobj pregnancies,of
R2014 T6504 T6505 dep that,passed
R2015 T6505 T6503 relcl passed,pregnancies
R2016 T6506 T6505 aux had,passed
R2017 T6507 T6505 auxpass been,passed
R2018 T6508 T6509 amod prior,to
R2019 T6509 T6505 prep to,passed
R2020 T6510 T6511 det the,induction
R2021 T6511 T6509 pobj induction,to
R2022 T6512 T6511 prep of,induction
R2023 T6513 T6514 det the,disease
R2024 T6514 T6512 pobj disease,of
R2025 T6515 T6487 punct .,was
R2026 T6517 T6518 nsubj We,observed
R2027 T6519 T6520 det a,trend
R2028 T6520 T6518 dobj trend,observed
R2029 T6521 T6520 prep towards,trend
R2030 T6522 T6523 amod lower,severity
R2031 T6523 T6521 pobj severity,towards
R2032 T6524 T6520 prep in,trend
R2033 T6525 T6526 amod multiparous,mice
R2034 T6526 T6524 pobj mice,in
R2035 T6527 T6520 prep compared,trend
R2036 T6528 T6527 prep with,compared
R2037 T6529 T6528 pobj mice,with
R2038 T6530 T6529 prep with,mice
R2039 T6531 T6532 det a,history
R2040 T6532 T6530 pobj history,with
R2041 T6533 T6532 prep of,history
R2042 T6534 T6535 quantmod zero,two
R2043 T6535 T6537 nummod two,pregnancies
R2044 T6536 T6535 quantmod to,two
R2045 T6537 T6533 pobj pregnancies,of
R2046 T6538 T6518 punct .,observed
R2047 T6540 T6541 det The,onset
R2048 T6541 T6542 nsubj onset,was
R2049 T6543 T6541 prep of,onset
R2050 T6544 T6543 pobj diseases,of
R2051 T6545 T6542 punct ", ",was
R2052 T6546 T6542 advmod however,was
R2053 T6547 T6542 punct ", ",was
R2054 T6548 T6542 acomp earlier,was
R2055 T6549 T6542 prep in,was
R2056 T6550 T6549 pobj mice,in
R2057 T6551 T6552 dep that,passed
R2058 T6552 T6550 relcl passed,mice
R2059 T6553 T6552 aux had,passed
R2060 T6554 T6555 amod more,one
R2061 T6555 T6557 nummod one,pregnancy
R2062 T6556 T6555 quantmod than,one
R2063 T6557 T6552 dobj pregnancy,passed
R2064 T6558 T6542 punct .,was
R2065 T6560 T6561 expl There,was
R2066 T6562 T6563 det no,difference
R2067 T6563 T6561 attr difference,was
R2068 T6564 T6563 prep in,difference
R2069 T6565 T6566 det the,development
R2070 T6566 T6564 pobj development,in
R2071 T6567 T6566 prep of,development
R2072 T6568 T6569 det the,disease
R2073 T6569 T6567 pobj disease,of
R2074 T6570 T6563 prep between,difference
R2075 T6571 T6572 amod female,mice
R2076 T6572 T6570 pobj mice,between
R2077 T6573 T6574 dep that,been
R2078 T6574 T6572 relcl been,mice
R2079 T6575 T6574 aux have,been
R2080 T6576 T6574 advmod only,been
R2081 T6577 T6574 acomp pregnant,been
R2082 T6578 T6577 prep with,pregnant
R2083 T6579 T6580 npadvmod MHC,mismatched
R2084 T6580 T6581 amod mismatched,males
R2085 T6581 T6578 pobj males,with
R2086 T6582 T6583 punct (,B10.RIII
R2087 T6583 T6581 parataxis B10.RIII,males
R2088 T6584 T6583 punct ),B10.RIII
R2089 T6585 T6572 cc and,mice
R2090 T6586 T6587 amod female,mice
R2091 T6587 T6572 conj mice,mice
R2092 T6588 T6589 dep that,been
R2093 T6589 T6587 relcl been,mice
R2094 T6590 T6589 advmod only,been
R2095 T6591 T6589 aux have,been
R2096 T6592 T6589 acomp pregnant,been
R2097 T6593 T6592 prep with,pregnant
R2098 T6594 T6595 npadvmod MHC,matched
R2099 T6595 T6596 amod matched,males
R2100 T6596 T6593 pobj males,with
R2101 T6597 T6598 punct (,B10.Q
R2102 T6598 T6596 parataxis B10.Q,males
R2103 T6599 T6598 punct ),B10.Q
R2104 T6600 T6561 punct .,was
R2105 T6854 T6855 amod New,loci
R2106 T6856 T6855 acl associated,loci
R2107 T6857 T6856 prep with,associated
R2108 T6858 T6857 pobj CIA,with
R2109 T6859 T6856 prep in,associated
R2110 T6860 T6861 amod identified,mice
R2111 T6861 T6859 pobj mice,in
R2112 T6862 T6861 amod old,mice
R2113 T6863 T6861 amod female,mice
R2114 T6865 T6866 det The,analysis
R2115 T6866 T6869 nsubj analysis,revealed
R2116 T6867 T6866 amod genetic,analysis
R2117 T6868 T6866 compound linkage,analysis
R2118 T6870 T6871 nummod one,locus
R2119 T6871 T6869 dobj locus,revealed
R2120 T6872 T6871 amod significant,locus
R2121 T6873 T6871 amod quantitative,locus
R2122 T6874 T6871 compound trait,locus
R2123 T6875 T6871 punct (,locus
R2124 T6876 T6871 appos QTL,locus
R2125 T6877 T6871 punct ),locus
R2126 T6878 T6871 acl located,locus
R2127 T6879 T6878 prep at,located
R2128 T6880 T6881 quantmod 64,70
R2129 T6881 T6883 nummod 70,cM
R2130 T6882 T6881 punct –,70
R2131 T6883 T6879 pobj cM,at
R2132 T6884 T6878 prep on,located
R2133 T6885 T6884 pobj chromosome,on
R2134 T6886 T6885 nummod 11,chromosome
R2135 T6887 T6888 punct (,Table
R2136 T6888 T6869 parataxis Table,revealed
R2137 T6889 T6888 nummod 3,Table
R2138 T6890 T6888 cc and,Table
R2139 T6891 T6888 conj Figure,Table
R2140 T6892 T6891 nummod 2,Figure
R2141 T6893 T6888 punct ),Table
R2142 T6894 T6869 punct .,revealed
R2143 T6896 T6897 det This,locus
R2144 T6897 T6898 nsubj locus,gave
R2145 T6899 T6897 punct (,locus
R2146 T6900 T6897 acl denoted,locus
R2147 T6901 T6900 oprd Cia40,denoted
R2148 T6902 T6898 punct ),gave
R2149 T6903 T6904 amod significant,scores
R2150 T6904 T6898 dobj scores,gave
R2151 T6905 T6904 compound LOD,scores
R2152 T6906 T6904 prep for,scores
R2153 T6907 T6908 det the,incidence
R2154 T6908 T6906 pobj incidence,for
R2155 T6909 T6908 compound traits,incidence
R2156 T6910 T6911 punct (,4.1
R2157 T6911 T6908 parataxis 4.1,incidence
R2158 T6912 T6911 nsubj LOD,4.1
R2159 T6913 T6911 punct =,4.1
R2160 T6914 T6911 punct ),4.1
R2161 T6915 T6908 cc and,incidence
R2162 T6916 T6917 punct ',day
R2163 T6917 T6908 conj day,incidence
R2164 T6918 T6917 prep of,day
R2165 T6919 T6918 pobj onset,of
R2166 T6920 T6917 punct ',day
R2167 T6921 T6922 punct (,4.0
R2168 T6922 T6917 parataxis 4.0,day
R2169 T6923 T6922 nsubj LOD,4.0
R2170 T6924 T6922 punct =,4.0
R2171 T6925 T6922 punct ),4.0
R2172 T6926 T6904 punct ", ",scores
R2173 T6927 T6904 cc and,scores
R2174 T6928 T6929 det a,score
R2175 T6929 T6904 conj score,scores
R2176 T6930 T6929 amod suggestive,score
R2177 T6931 T6929 compound LOD,score
R2178 T6932 T6929 prep for,score
R2179 T6933 T6934 det the,score
R2180 T6934 T6932 pobj score,for
R2181 T6935 T6934 nmod trait,score
R2182 T6936 T6934 punct ',score
R2183 T6937 T6934 compound arthritis,score
R2184 T6938 T6929 punct ',score
R2185 T6939 T6940 punct (,3.3
R2186 T6940 T6929 parataxis 3.3,score
R2187 T6941 T6940 nsubj LOD,3.3
R2188 T6942 T6940 punct =,3.3
R2189 T6943 T6940 punct ),3.3
R2190 T6944 T6898 punct .,gave
R2191 T6946 T6947 det Another,QTL
R2192 T6947 T6948 nsubjpass QTL,identified
R2193 T6949 T6947 prep of,QTL
R2194 T6950 T6951 amod suggestive,significance
R2195 T6951 T6949 pobj significance,of
R2196 T6952 T6951 prep for,significance
R2197 T6953 T6954 det the,incidence
R2198 T6954 T6952 pobj incidence,for
R2199 T6955 T6954 prep of,incidence
R2200 T6956 T6955 pobj disease,of
R2201 T6957 T6948 auxpass was,identified
R2202 T6958 T6948 prep around,identified
R2203 T6959 T6960 nummod 27,cM
R2204 T6960 T6958 pobj cM,around
R2205 T6961 T6948 prep on,identified
R2206 T6962 T6961 pobj chromosome,on
R2207 T6963 T6962 nummod 1,chromosome
R2208 T6964 T6965 punct (,Figure
R2209 T6965 T6948 parataxis Figure,identified
R2210 T6966 T6965 nummod 2,Figure
R2211 T6967 T6965 punct ),Figure
R2212 T6968 T6948 punct .,identified
R2213 T6970 T6971 advmod Finally,identified
R2214 T6972 T6971 punct ", ",identified
R2215 T6973 T6974 det a,QTL
R2216 T6974 T6971 nsubjpass QTL,identified
R2217 T6975 T6974 amod suggestive,QTL
R2218 T6976 T6974 prep for,QTL
R2219 T6977 T6978 det the,trait
R2220 T6978 T6976 pobj trait,for
R2221 T6979 T6980 amod anti-CII,titer
R2222 T6980 T6978 appos titer,trait
R2223 T6981 T6980 compound antibody,titer
R2224 T6982 T6971 auxpass was,identified
R2225 T6983 T6971 prep on,identified
R2226 T6984 T6983 pobj chromosome,on
R2227 T6985 T6984 nummod 13,chromosome
R2228 T6986 T6987 punct (,Figure
R2229 T6987 T6971 parataxis Figure,identified
R2230 T6988 T6987 nummod 2,Figure
R2231 T6989 T6987 punct ),Figure
R2232 T6990 T6971 punct .,identified
R2233 T9016 T9017 mark Although,carrying
R2234 T9017 T9018 advcl carrying,are
R2235 T9019 T9020 det the,region
R2236 T9020 T9017 dobj region,carrying
R2237 T9021 T9020 amod same,region
R2238 T9022 T9023 npadvmod CIA,susceptible
R2239 T9023 T9020 amod susceptible,region
R2241 T9025 T9020 compound MHC,region
R2242 T9026 T9018 punct ", ",are
R2243 T9027 T9028 det the,mice
R2244 T9028 T9018 nsubj mice,are
R2245 T9029 T9030 nmod NFR,N
R2246 T9030 T9028 nmod N,mice
R2248 T9032 T9030 cc and,N
R2249 T9033 T9030 conj B10.Q,N
R2250 T9034 T9018 acomp different,are
R2251 T9035 T9018 prep in,are
R2252 T9036 T9037 amod several,respects
R2253 T9037 T9035 pobj respects,in
R2254 T9038 T9018 punct .,are
R2255 T9040 T9041 det The,mouse
R2256 T9041 T9045 nsubj mouse,is
R2257 T9042 T9043 compound NFR,N
R2258 T9043 T9041 compound N,mouse
R2260 T9046 T9041 punct ", ",mouse
R2261 T9047 T9048 dep which,is
R2262 T9048 T9041 relcl is,mouse
R2263 T9049 T9050 det an,mouse
R2264 T9050 T9048 attr mouse,is
R2265 T9051 T9050 amod inbred,mouse
R2266 T9052 T9050 compound NMRI,mouse
R2267 T9053 T9050 prep of,mouse
R2268 T9054 T9055 det the,haplotype
R2269 T9055 T9053 pobj haplotype,of
R2270 T9056 T9057 compound H,2q
R2271 T9057 T9055 compound 2q,haplotype
R2273 T9059 T9045 punct ", ",is
R2274 T9060 T9045 acomp larger,is
R2275 T9061 T9060 prep in,larger
R2276 T9062 T9061 pobj size,in
R2277 T9063 T9060 prep than,larger
R2278 T9064 T9065 det the,mouse
R2279 T9065 T9063 pobj mouse,than
R2280 T9066 T9065 compound B10.Q,mouse
R2281 T9067 T9045 cc and,is
R2282 T9068 T9069 auxpass is,known
R2283 T9069 T9045 conj known,is
R2284 T9070 T9069 advmod also,known
R2285 T9071 T9069 prep for,known
R2286 T9072 T9073 poss its,properties
R2287 T9073 T9071 pobj properties,for
R2288 T9074 T9075 advmod extraordinarily,good
R2289 T9075 T9073 amod good,properties
R2290 T9076 T9073 compound breeding,properties
R2291 T9077 T9045 punct .,is
R2292 T9079 T9080 det The,mice
R2293 T9080 T9081 nsubj mice,underwent
R2294 T9082 T9080 acl used,mice
R2295 T9083 T9082 prep in,used
R2296 T9084 T9085 det the,study
R2297 T9085 T9083 pobj study,in
R2298 T9086 T9085 amod present,study
R2299 T9087 T9080 punct ", ",mice
R2300 T9088 T9089 punct (,N
R2301 T9089 T9092 nmod N,females
R2302 T9090 T9089 nmod NFR,N
R2303 T9091 T9089 punct /,N
R2304 T9092 T9080 appos females,mice
R2305 T9093 T9089 punct ×,N
R2306 T9094 T9089 appos B10.Q,N
R2307 T9095 T9089 punct ),N
R2308 T9096 T9089 punct ×,N
R2309 T9097 T9089 appos B10.Q,N
R2310 T9098 T9081 punct ", ",underwent
R2311 T9099 T9081 advmod first,underwent
R2312 T9100 T9101 det a,study
R2313 T9101 T9081 dobj study,underwent
R2314 T9102 T9101 amod genetic,study
R2315 T9103 T9101 prep of,study
R2316 T9104 T9103 pobj reproduction,of
R2317 T9105 T9101 punct ", ",study
R2318 T9106 T9107 prep in,identified
R2319 T9107 T9101 relcl identified,study
R2320 T9108 T9106 pobj which,in
R2321 T9109 T9110 det a,number
R2322 T9110 T9107 nsubjpass number,identified
R2323 T9111 T9110 prep of,number
R2324 T9112 T9111 pobj loci,of
R2325 T9113 T9112 acl associated,loci
R2326 T9114 T9113 prep with,associated
R2327 T9115 T9116 compound breeding,performance
R2328 T9116 T9114 pobj performance,with
R2329 T9117 T9107 auxpass were,identified
R2330 T9118 T9119 punct (,Liljander
R2331 T9119 T9081 meta Liljander,underwent
R2332 T9120 T9119 nmod M,Liljander
R2333 T9121 T9119 punct ", ",Liljander
R2334 T9122 T9119 nmod Sällström,Liljander
R2335 T9123 T9119 nmod MA,Liljander
R2336 T9124 T9119 punct ", ",Liljander
R2337 T9125 T9119 nmod Andersson,Liljander
R2338 T9126 T9119 nmod S,Liljander
R2339 T9127 T9119 punct ", ",Liljander
R2340 T9128 T9119 nmod Wernhoff,Liljander
R2341 T9129 T9119 nmod P,Liljander
R2342 T9130 T9119 punct ", ",Liljander
R2343 T9131 T9119 nmod Andersson,Liljander
R2344 T9132 T9119 nmod Å,Liljander
R2345 T9133 T9119 punct ", ",Liljander
R2346 T9134 T9119 nmod Holmdahl,Liljander
R2347 T9135 T9119 nmod R,Liljander
R2348 T9136 T9119 punct ", ",Liljander
R2349 T9137 T9119 nmod Mattsson,Liljander
R2350 T9138 T9119 nmod R,Liljander
R2351 T9139 T9119 punct ;,Liljander
R2352 T9140 T9119 amod unpublished,Liljander
R2353 T9141 T9119 nmod data,Liljander
R2354 T9142 T9119 punct ),Liljander
R2355 T9143 T9081 punct .,underwent
R2356 T9145 T9146 mark Since,differ
R2357 T9146 T9150 advcl differ,wanted
R2358 T9147 T9148 det the,strains
R2359 T9148 T9146 nsubj strains,differ
R2361 T9151 T9146 prep in,differ
R2362 T9152 T9151 pobj susceptibility,in
R2363 T9153 T9152 prep to,susceptibility
R2364 T9154 T9153 pobj CIA,to
R2365 T9155 T9146 punct ", ",differ
R2366 T9156 T9146 prep in,differ
R2367 T9157 T9156 pobj spite,in
R2368 T9158 T9157 prep of,spite
R2369 T9159 T9160 nsubj both,having
R2370 T9160 T9158 pcomp having,of
R2371 T9161 T9162 det the,genes
R2372 T9162 T9160 dobj genes,having
R2373 T9163 T9162 nmod MHC,genes
R2374 T9164 T9165 nmod class,A
R2375 T9165 T9162 compound A,genes
R2377 T9167 T9162 compound beta,genes
R2378 T9168 T9169 punct [,15
R2379 T9169 T9160 parataxis 15,having
R2380 T9170 T9169 punct ],15
R2381 T9171 T9150 punct ", ",wanted
R2382 T9172 T9150 nsubj we,wanted
R2383 T9173 T9174 aux to,test
R2384 T9174 T9150 xcomp test,wanted
R2385 T9175 T9176 det the,susceptibility
R2386 T9176 T9174 dobj susceptibility,test
R2387 T9177 T9176 prep to,susceptibility
R2388 T9178 T9179 amod inflammatory,disease
R2389 T9179 T9177 pobj disease,to
R2390 T9180 T9174 prep in,test
R2391 T9181 T9180 pobj mice,in
R2392 T9182 T9181 prep from,mice
R2393 T9183 T9184 det this,cross
R2394 T9184 T9182 pobj cross,from
R2395 T9185 T9150 punct .,wanted
R2396 T9187 T9188 prep In,gave
R2397 T9189 T9187 pobj fact,In
R2398 T9190 T9188 punct ", ",gave
R2399 T9191 T9192 det this,situation
R2400 T9192 T9188 nsubj situation,gave
R2401 T9193 T9194 det an,opportunity
R2402 T9194 T9188 dobj opportunity,gave
R2403 T9195 T9196 aux to,study
R2404 T9196 T9194 acl study,opportunity
R2405 T9197 T9198 det the,control
R2406 T9198 T9196 dobj control,study
R2407 T9199 T9198 amod genetic,control
R2408 T9200 T9198 prep of,control
R2409 T9201 T9200 pobj arthritis,of
R2410 T9202 T9196 prep in,study
R2411 T9203 T9204 amod aged,females
R2412 T9204 T9202 pobj females,in
R2413 T9205 T9204 amod multiparous,females
R2414 T9206 T9204 punct ", ",females
R2415 T9207 T9208 det a,situation
R2416 T9208 T9204 appos situation,females
R2417 T9209 T9208 amod common,situation
R2418 T9210 T9208 prep in,situation
R2419 T9211 T9212 amod human,RA
R2420 T9212 T9210 pobj RA,in
R2421 T9213 T9188 punct .,gave
R2422 T9215 T9216 det This,susceptibility
R2423 T9216 T9217 nsubj susceptibility,was
R2424 T9218 T9217 acomp important,was
R2425 T9219 T9220 aux to,investigate
R2426 T9220 T9218 advcl investigate,important
R2427 T9221 T9217 prep for,was
R2428 T9222 T9223 amod various,reasons
R2429 T9223 T9221 pobj reasons,for
R2430 T9224 T9217 punct .,was
R2431 T9226 T9227 det The,fact
R2432 T9227 T9228 nsubj fact,made
R2433 T9229 T9230 mark that,differed
R2434 T9230 T9227 acl differed,fact
R2435 T9231 T9232 det the,mice
R2436 T9232 T9230 nsubj mice,differed
R2437 T9233 T9230 prep in,differed
R2438 T9234 T9235 poss their,history
R2439 T9235 T9233 pobj history,in
R2440 T9236 T9235 amod reproductive,history
R2441 T9237 T9238 nsubj it,possible
R2442 T9238 T9228 ccomp possible,made
R2443 T9239 T9240 aux to,analyze
R2444 T9240 T9238 advcl analyze,possible
R2445 T9241 T9242 mark whether,affect
R2446 T9242 T9240 ccomp affect,analyze
R2447 T9243 T9242 nsubj this,affect
R2448 T9244 T9242 aux would,affect
R2449 T9245 T9242 advmod significantly,affect
R2450 T9246 T9247 det the,incidence
R2451 T9247 T9242 dobj incidence,affect
R2452 T9248 T9247 cc or,incidence
R2453 T9249 T9247 conj severity,incidence
R2454 T9250 T9247 prep of,incidence
R2455 T9251 T9250 pobj CIA,of
R2456 T9252 T9228 punct .,made
R2457 T9254 T9255 advmod Second,carried
R2458 T9256 T9255 punct ", ",carried
R2459 T9257 T9258 advmod almost,analyses
R2460 T9258 T9255 nsubjpass analyses,carried
R2461 T9259 T9258 predet all,analyses
R2462 T9260 T9258 det the,analyses
R2463 T9261 T9258 compound linkage,analyses
R2464 T9262 T9258 acl performed,analyses
R2465 T9263 T9262 prep for,performed
R2466 T9264 T9263 pobj detection,for
R2467 T9265 T9264 prep of,detection
R2468 T9266 T9267 npadvmod CIA,associated
R2469 T9267 T9269 amod associated,loci
R2470 T9268 T9267 punct -,associated
R2471 T9269 T9265 pobj loci,of
R2472 T9270 T9264 prep in,detection
R2473 T9271 T9270 pobj mice,in
R2474 T9272 T9255 aux have,carried
R2475 T9273 T9255 auxpass been,carried
R2476 T9274 T9255 prt out,carried
R2477 T9275 T9255 prep with,carried
R2478 T9276 T9277 amod male,mice
R2479 T9277 T9275 pobj mice,with
R2480 T9278 T9255 punct .,carried
R2481 T9280 T9281 det Another,reason
R2482 T9281 T9282 nsubj reason,is
R2483 T9283 T9284 mark that,mimicked
R2484 T9284 T9282 ccomp mimicked,is
R2485 T9285 T9286 det the,use
R2486 T9286 T9284 nsubj use,mimicked
R2487 T9287 T9286 prep of,use
R2488 T9288 T9289 amod old,mice
R2489 T9289 T9287 pobj mice,of
R2491 T9291 T9292 det the,situation
R2492 T9292 T9284 dobj situation,mimicked
R2493 T9293 T9292 compound RA,situation
R2494 T9294 T9295 punct (,is
R2495 T9295 T9284 parataxis is,mimicked
R2496 T9296 T9297 amod older,women
R2497 T9297 T9295 nsubj women,is
R2498 T9298 T9299 det the,group
R2499 T9299 T9295 attr group,is
R2500 T9300 T9301 amod major,risk
R2501 T9301 T9299 compound risk,group
R2502 T9302 T9295 punct ),is
R2503 T9303 T9282 punct .,is
R2504 T9305 T9306 advmod Finally,used
R2505 T9307 T9306 punct ", ",used
R2506 T9308 T9309 det the,strain
R2507 T9309 T9306 nsubjpass strain,used
R2508 T9310 T9311 compound NFR,N
R2509 T9311 T9309 compound N,strain
R2511 T9313 T9306 aux had,used
R2512 T9314 T9306 neg not,used
R2513 T9315 T9306 advmod previously,used
R2514 T9316 T9306 auxpass been,used
R2515 T9317 T9306 prep in,used
R2516 T9318 T9319 compound linkage,analyses
R2517 T9319 T9317 pobj analyses,in
R2518 T9320 T9306 prep for,used
R2519 T9321 T9320 pobj detection,for
R2520 T9322 T9321 prep of,detection
R2521 T9323 T9324 npadvmod CIA,associated
R2522 T9324 T9326 amod associated,loci
R2523 T9325 T9324 punct -,associated
R2524 T9326 T9322 pobj loci,of
R2525 T9327 T9306 punct ", ",used
R2526 T9328 T9329 dep which,opened
R2527 T9329 T9306 advcl opened,used
R2528 T9330 T9329 punct (,opened
R2529 T9331 T9329 prt up,opened
R2530 T9332 T9329 punct ),opened
R2531 T9333 T9334 det the,possibility
R2532 T9334 T9329 dobj possibility,opened
R2533 T9335 T9334 prep of,possibility
R2534 T9336 T9335 pcomp detecting,of
R2535 T9337 T9338 amod new,genes
R2536 T9338 T9336 dobj genes,detecting
R2537 T9339 T9338 amod polymorphic,genes
R2538 T9340 T9338 prep of,genes
R2539 T9341 T9340 pobj importance,of
R2540 T9342 T9336 prep in,detecting
R2541 T9343 T9344 det this,disease
R2542 T9344 T9342 pobj disease,in
R2543 T9345 T9306 punct .,used
R2544 T9347 T9348 det The,conclusion
R2545 T9348 T9350 nsubj conclusion,is
R2546 T9349 T9348 amod first,conclusion
R2547 T9351 T9348 prep from,conclusion
R2548 T9352 T9353 det the,paper
R2549 T9353 T9351 pobj paper,from
R2550 T9354 T9353 amod present,paper
R2551 T9355 T9356 mark that,influence
R2552 T9356 T9350 ccomp influence,is
R2553 T9357 T9356 nsubj multiparity,influence
R2554 T9358 T9356 aux does,influence
R2555 T9359 T9356 neg not,influence
R2556 T9360 T9356 advmod negatively,influence
R2557 T9361 T9362 det the,incidence
R2558 T9362 T9356 dobj incidence,influence
R2559 T9363 T9362 cc or,incidence
R2560 T9364 T9362 conj severity,incidence
R2561 T9365 T9362 prep of,incidence
R2562 T9366 T9365 pobj CIA,of
R2563 T9367 T9366 acl induced,CIA
R2564 T9368 T9367 advmod later,induced
R2565 T9369 T9368 prep in,later
R2566 T9370 T9369 pobj life,in
R2567 T9371 T9372 punct (,Table
R2568 T9372 T9356 parataxis Table,influence
R2569 T9373 T9372 nummod 2,Table
R2570 T9374 T9372 punct ),Table
R2571 T9375 T9350 punct .,is
R2572 T9377 T9378 nsubj This,is
R2573 T9379 T9378 prep in,is
R2574 T9380 T9379 pobj agreement,in
R2575 T9381 T9380 prep with,agreement
R2576 T9382 T9381 pobj results,with
R2577 T9383 T9382 prep from,results
R2578 T9384 T9385 det a,study
R2579 T9385 T9383 pobj study,from
R2580 T9386 T9385 amod recent,study
R2581 T9387 T9385 prep of,study
R2582 T9388 T9387 pobj RA,of
R2583 T9389 T9388 prep in,RA
R2584 T9390 T9389 pobj women,in
R2585 T9391 T9385 punct ", ",study
R2586 T9392 T9393 dep which,indicates
R2587 T9393 T9385 relcl indicates,study
R2588 T9394 T9393 advmod similarly,indicates
R2589 T9395 T9396 mark that,affect
R2590 T9396 T9393 ccomp affect,indicates
R2591 T9397 T9398 amod previous,experience
R2592 T9398 T9396 nsubj experience,affect
R2593 T9399 T9398 prep of,experience
R2594 T9400 T9399 pobj pregnancy,of
R2595 T9401 T9396 aux does,affect
R2596 T9402 T9396 neg not,affect
R2597 T9403 T9396 advmod negatively,affect
R2598 T9404 T9405 det the,incidence
R2599 T9405 T9396 dobj incidence,affect
R2600 T9406 T9405 cc or,incidence
R2601 T9407 T9405 conj severity,incidence
R2602 T9408 T9405 prep of,incidence
R2603 T9409 T9408 pobj RA,of
R2604 T9410 T9396 advmod later,affect
R2605 T9411 T9410 prep in,later
R2606 T9412 T9411 pobj life,in
R2607 T9413 T9414 punct [,8
R2608 T9414 T9378 parataxis 8,is
R2609 T9415 T9414 punct ],8
R2610 T9416 T9378 punct .,is
R2611 T9418 T9419 nsubj It,is
R2612 T9420 T9419 acomp worth,is
R2613 T9421 T9420 advcl noting,worth
R2614 T9422 T9423 mark that,is
R2615 T9423 T9419 ccomp is,is
R2616 T9424 T9425 det the,situation
R2617 T9425 T9423 nsubj situation,is
R2618 T9426 T9427 advmod quite,different
R2619 T9427 T9423 acomp different,is
R2620 T9428 T9429 mark if,entered
R2621 T9429 T9423 advcl entered,is
R2622 T9430 T9429 nsubjpass pregnancy,entered
R2623 T9431 T9429 auxpass is,entered
R2624 T9432 T9429 prep during,entered
R2625 T9433 T9434 amod ongoing,arthritis
R2626 T9434 T9432 pobj arthritis,during
R2627 T9435 T9419 punct .,is
R2628 T9437 T9438 nsubj This,lead
R2629 T9439 T9438 aux will,lead
R2630 T9440 T9438 advmod normally,lead
R2631 T9441 T9438 prep to,lead
R2632 T9442 T9443 det a,remission
R2633 T9443 T9441 pobj remission,to
R2634 T9444 T9443 amod temporary,remission
R2635 T9445 T9443 prep of,remission
R2636 T9446 T9447 det the,disease
R2637 T9447 T9445 pobj disease,of
R2638 T9448 T9443 prep in,remission
R2639 T9449 T9450 preconj both,mice
R2640 T9450 T9448 pobj mice,in
R2641 T9451 T9450 cc and,mice
R2642 T9530 T9522 conj Cia20,Cia15
R2643 T9452 T9450 conj humans,mice
R2644 T9531 T9530 prep at,Cia20
R2646 T9532 T9533 nummod 44,cM
R2647 T9533 T9531 pobj cM,at
R2648 T9534 T9535 punct [,16
R2649 T9454 T9443 acl followed,remission
R2650 T9535 T9530 parataxis 16,Cia20
R2651 T9536 T9535 punct ],16
R2652 T9455 T9454 agent by,followed
R2653 T9537 T9530 cc and,Cia20
R2654 T9538 T9530 conj Cia9,Cia20
R2655 T9539 T9538 prep at,Cia9
R2656 T9540 T9541 nummod 92,cM
R2657 T9541 T9539 pobj cM,at
R2658 T9542 T9543 punct [,17
R2659 T9456 T9457 det an,phase
R2660 T9543 T9538 parataxis 17,Cia9
R2661 T9544 T9543 punct ],17
R2662 T9545 T9514 punct .,identified
R2663 T9457 T9455 pobj phase,by
R2664 T9547 T9548 advmod However,appears
R2665 T9458 T9457 compound exacerbation,phase
R2666 T9549 T9548 punct ", ",appears
R2667 T9550 T9548 nsubj none,appears
R2668 T9459 T9457 prep after,phase
R2669 T9551 T9550 prep of,none
R2670 T9552 T9553 det these,loci
R2671 T9553 T9551 pobj loci,of
R2672 T9554 T9555 aux to,be
R2673 T9460 T9459 pobj delivery,after
R2674 T9555 T9548 xcomp be,appears
R2675 T9556 T9555 advmod close,be
R2676 T9461 T9462 punct [,11
R2677 T9557 T9556 prep to,close
R2678 T9558 T9559 det the,locus
R2679 T9559 T9557 pobj locus,to
R2680 T9462 T9438 parataxis 11,lead
R2681 T9560 T9559 acl found,locus
R2682 T9561 T9560 prep on,found
R2683 T9463 T9462 nummod 7,11
R2684 T9562 T9561 pobj chromosome,on
R2685 T9563 T9562 nummod 1,chromosome
R2686 T9564 T9560 prep in,found
R2687 T9565 T9566 det the,study
R2688 T9464 T9462 punct ",",11
R2689 T9566 T9564 pobj study,in
R2690 T9567 T9566 amod present,study
R2691 T9568 T9548 punct .,appears
R2692 T9465 T9462 nummod 10,11
R2693 T9570 T9571 det The,locus
R2694 T9571 T9575 nsubj locus,includes
R2695 T9466 T9462 punct ",",11
R2696 T9572 T9573 advmod newly,identified
R2697 T9573 T9571 amod identified,locus
R2698 T9574 T9571 compound Cia40,locus
R2699 T9467 T9462 punct ],11
R2700 T9576 T9577 det the,gene
R2701 T9468 T9438 punct .,lead
R2702 T9577 T9575 dobj gene,includes
R2703 T9578 T9577 nmod Ctla4,gene
R2704 T9579 T9580 punct (,CD152
R2705 T9470 T9471 det The,conclusion
R2706 T9580 T9578 parataxis CD152,Ctla4
R2707 T9581 T9580 punct ),CD152
R2708 T9582 T9577 punct ", ",gene
R2709 T9583 T9584 dep which,is
R2710 T9584 T9577 relcl is,gene
R2711 T9585 T9586 det a,candidate
R2712 T9586 T9584 attr candidate,is
R2713 T9471 T9473 nsubj conclusion,is
R2714 T9587 T9586 amod strong,candidate
R2715 T9588 T9586 acl associated,candidate
R2716 T9589 T9588 prep with,associated
R2717 T9472 T9471 amod second,conclusion
R2718 T9590 T9591 amod spontaneous,diabetes
R2719 T9591 T9589 pobj diabetes,with
R2720 T9592 T9586 acl identified,candidate
R2721 T9474 T9471 prep from,conclusion
R2722 T9593 T9592 prep in,identified
R2723 T9594 T9593 pobj crosses,in
R2724 T9595 T9594 prep between,crosses
R2725 T9596 T9595 pobj C57Bl,between
R2726 T9475 T9476 det this,study
R2727 T9597 T9596 cc and,C57Bl
R2728 T9476 T9474 pobj study,from
R2729 T9477 T9478 mark that,detected
R2730 T9598 T9599 amod nonobese,strains
R2731 T9478 T9473 ccomp detected,is
R2732 T9599 T9596 conj strains,C57Bl
R2733 T9600 T9599 amod diabetic,strains
R2734 T9601 T9602 punct [,18
R2735 T9479 T9478 nsubjpass loci,detected
R2736 T9602 T9575 parataxis 18,includes
R2737 T9480 T9479 prep of,loci
R2738 T9603 T9602 punct ],18
R2739 T9604 T9575 punct .,includes
R2740 T9606 T9607 nsubj Analyses,identify
R2741 T9481 T9482 amod possible,importance
R2742 T9608 T9606 prep of,Analyses
R2743 T9482 T9480 pobj importance,of
R2744 T9609 T9608 pobj CIA,of
R2745 T9610 T9606 prep in,Analyses
R2746 T9611 T9610 pobj crosses,in
R2747 T9483 T9482 prep for,importance
R2748 T9612 T9611 prep of,crosses
R2749 T9613 T9614 det the,backgrounds
R2750 T9614 T9612 pobj backgrounds,of
R2751 T9484 T9483 pobj CIA,for
R2752 T9615 T9614 amod same,backgrounds
R2753 T9616 T9607 punct ", ",identify
R2754 T9617 T9607 advmod however,identify
R2755 T9485 T9478 aux have,detected
R2756 T9618 T9607 punct ", ",identify
R2757 T9619 T9607 aux did,identify
R2758 T9620 T9607 neg not,identify
R2759 T9621 T9622 det a,linkage
R2760 T9622 T9607 dobj linkage,identify
R2761 T9623 T9622 prep to,linkage
R2762 T9486 T9478 auxpass been,detected
R2763 T9624 T9625 det this,locus
R2764 T9625 T9623 pobj locus,to
R2765 T9626 T9607 punct ", ",identify
R2766 T9487 T9478 punct ", ",detected
R2767 T9627 T9607 advcl suggesting,identify
R2768 T9628 T9629 mark that,differs
R2769 T9629 T9627 ccomp differs,suggesting
R2770 T9488 T9478 dobj two,detected
R2771 T9630 T9631 det the,polymorphism
R2772 T9631 T9629 nsubj polymorphism,differs
R2773 T9632 T9631 acl underlying,polymorphism
R2774 T9489 T9488 acl associated,two
R2775 T9633 T9632 dobj Cia40,underlying
R2776 T9634 T9629 prep from,differs
R2777 T9635 T9636 det the,genes
R2778 T9490 T9489 prep with,associated
R2779 T9491 T9492 compound arthritis,susceptibility
R2780 T9492 T9490 pobj susceptibility,with
R2781 T9493 T9488 punct (,two
R2782 T9494 T9495 nmod chromosomes,1
R2783 T9636 T9634 pobj genes,from
R2784 T9637 T9636 acl associated,genes
R2785 T9495 T9488 appos 1,two
R2786 T9638 T9637 prep with,associated
R2787 T9639 T9638 pobj diabetes,with
R2788 T9640 T9641 punct [,18
R2789 T9496 T9495 cc and,1
R2790 T9641 T9607 parataxis 18,identify
R2791 T9642 T9641 punct ],18
R2792 T9497 T9495 conj 11,1
R2793 T9643 T9607 punct .,identify
R2794 T9498 T9488 punct ),two
R2795 T9645 T9646 advmod Interestingly,identified
R2796 T9647 T9646 punct ", ",identified
R2797 T9499 T9488 cc and,two
R2798 T9648 T9646 nsubj Bauer,identified
R2799 T9649 T9648 cc and,Bauer
R2800 T9650 T9648 conj colleagues,Bauer
R2801 T9500 T9488 conj one,two
R2802 T9651 T9646 advmod previously,identified
R2803 T9652 T9653 det a,locus
R2804 T9501 T9500 acl associated,one
R2805 T9653 T9646 dobj locus,identified
R2806 T9654 T9655 punct (,Cia28
R2807 T9655 T9653 parataxis Cia28,locus
R2808 T9502 T9501 prep with,associated
R2809 T9656 T9655 punct ),Cia28
R2810 T9657 T9653 acl associated,locus
R2811 T9658 T9657 prep with,associated
R2812 T9659 T9660 amod anti-CII,production
R2813 T9660 T9658 pobj production,with
R2814 T9661 T9660 compound antibody,production
R2815 T9662 T9646 prep at,identified
R2816 T9503 T9504 amod anti-CII,titers
R2817 T9663 T9664 nummod 53,cM
R2818 T9664 T9662 pobj cM,at
R2819 T9665 T9664 prep on,cM
R2820 T9504 T9502 pobj titers,with
R2821 T9666 T9665 pobj chromosome,on
R2822 T9667 T9666 nummod 13,chromosome
R2823 T9668 T9669 punct [,19
R2824 T9505 T9500 punct (,one
R2825 T9669 T9666 parataxis 19,chromosome
R2826 T9670 T9669 punct ],19
R2827 T9671 T9664 punct ", ",cM
R2828 T9506 T9500 appos chromosome,one
R2829 T9672 T9673 dep which,is
R2830 T9673 T9664 relcl is,cM
R2831 T9507 T9506 nummod 13,chromosome
R2832 T9674 T9675 advmod approximately,at
R2833 T9675 T9673 prep at,is
R2834 T9676 T9677 det the,position
R2835 T9508 T9473 punct ),is
R2836 T9677 T9675 pobj position,at
R2837 T9678 T9677 amod same,position
R2838 T9509 T9473 punct .,is
R2839 T9679 T9677 prep as,position
R2840 T9680 T9681 advmod where,find
R2841 T9511 T9512 det Some,loci
R2842 T9681 T9679 pcomp find,as
R2843 T9512 T9514 nsubjpass loci,identified
R2844 T9682 T9681 nsubj we,find
R2845 T9683 T9684 det the,linkage
R2846 T9684 T9681 dobj linkage,find
R2847 T9513 T9512 compound arthritis,loci
R2848 T9685 T9684 prep for,linkage
R2849 T9515 T9514 aux have,identified
R2850 T9686 T9687 det this,trait
R2851 T9687 T9685 pobj trait,for
R2852 T9688 T9681 prep in,find
R2853 T9689 T9690 det the,study
R2854 T9516 T9514 advmod previously,identified
R2855 T9690 T9688 pobj study,in
R2856 T9691 T9690 amod present,study
R2857 T9517 T9514 auxpass been,identified
R2858 T9692 T9646 punct .,identified
R2859 T9518 T9514 prep on,identified
R2860 T9694 T9695 nsubj It,is
R2861 T9696 T9695 advmod therefore,is
R2862 T9519 T9518 pobj chromosome,on
R2863 T9697 T9698 advmod most,likely
R2864 T9698 T9695 acomp likely,is
R2865 T9699 T9700 mark that,is
R2866 T9700 T9695 ccomp is,is
R2867 T9701 T9702 det the,QTL
R2868 T9520 T9519 nummod 1,chromosome
R2869 T9702 T9700 nsubj QTL,is
R2870 T9703 T9704 nsubj we,identified
R2871 T9704 T9702 advcl identified,QTL
R2872 T9521 T9514 punct : ,identified
R2873 T9705 T9704 aux have,identified
R2874 T9706 T9704 prep on,identified
R2875 T9707 T9706 pobj chromosome,on
R2876 T9522 T9514 dep Cia15,identified
R2877 T9708 T9707 nummod 13,chromosome
R2878 T9709 T9710 det the,same
R2879 T9523 T9522 prep at,Cia15
R2880 T9710 T9700 attr same,is
R2881 T9711 T9710 prep as,same
R2882 T9712 T9711 pobj Cia28,as
R2883 T9524 T9525 nummod 8,cM
R2884 T9713 T9695 punct .,is
R2885 T9525 T9523 pobj cM,at
R2886 T9715 T9716 mark Since,was
R2887 T9716 T9727 advcl was,paying
R2888 T9717 T9718 det the,locus
R2889 T9526 T9527 punct [,16
R2890 T9718 T9716 nsubj locus,was
R2891 T9719 T9718 amod possible,locus
R2892 T9720 T9718 amod new,locus
R2893 T9527 T9522 parataxis 16,Cia15
R2894 T9721 T9718 prep of,locus
R2895 T9722 T9723 amod potential,interest
R2896 T9723 T9721 pobj interest,of
R2897 T9528 T9527 punct ],16
R2898 T9724 T9718 prep on,locus
R2899 T9725 T9724 pobj chromosome,on
R2900 T9529 T9522 punct ", ",Cia15
R2901 T9726 T9725 nummod 1,chromosome
R2902 T9728 T9716 prep of,was
R2903 T9742 T9734 attr Cia28,is
R2904 T9729 T9730 amod suggestive,significance
R2905 T9730 T9728 pobj significance,of
R2906 T9731 T9716 punct ", ",was
R2907 T9732 T9716 cc and,was
R2908 T9743 T9727 punct ", ",paying
R2910 T9734 T9716 conj is,was
R2911 T9735 T9736 det the,locus
R2912 T9744 T9727 nsubj we,paying
R2913 T9736 T9734 nsubj locus,is
R2914 T9737 T9736 acl identified,locus
R2915 T9738 T9737 prep on,identified
R2916 T9745 T9727 aux are,paying
R2917 T9739 T9738 pobj chromosome,on
R2918 T9740 T9739 nummod 13,chromosome
R2919 T9741 T9734 advmod probably,is
R2920 T9746 T9727 advmod now,paying
R2921 T9747 T9748 amod special,attention
R2922 T9748 T9727 dobj attention,paying
R2923 T9749 T9727 prep to,paying
R2924 T9848 T9842 auxpass is,located
R2925 T9849 T9842 neg not,located
R2927 T9851 T9842 prep in,located
R2929 T9852 T9853 det the,vicinity
R2930 T9853 T9851 pobj vicinity,in
R2931 T9752 T9751 amod significant,QTL
R2932 T9753 T9751 prep for,QTL
R2933 T9854 T9853 prep of,vicinity
R2934 T9855 T9854 pobj Cia40,of
R2935 T9856 T9850 punct ", ",is
R2936 T9754 T9755 compound CIA,incidence
R2937 T9857 T9850 nsubj it,is
R2938 T9858 T9850 acomp worth,is
R2939 T9859 T9858 advcl noting,worth
R2940 T9755 T9753 pobj incidence,for
R2941 T9860 T9861 punct [,23
R2942 T9861 T9850 parataxis 23,is
R2943 T9862 T9861 punct ],23
R2944 T9756 T9751 acl detected,QTL
R2945 T9863 T9850 punct .,is
R2946 T9757 T9756 prep at,detected
R2947 T9865 T9866 det The,chromosome
R2948 T9866 T9868 nsubj chromosome,contains
R2949 T9867 T9866 compound mouse,chromosome
R2950 T9758 T9759 quantmod 60,70
R2951 T9869 T9866 nummod 11,chromosome
R2952 T9870 T9871 amod several,genes
R2953 T9871 T9868 dobj genes,contains
R2954 T9759 T9761 nummod 70,cM
R2955 T9872 T9873 dep that,are
R2956 T9873 T9871 relcl are,genes
R2957 T9874 T9875 advmod highly,conserved
R2958 T9760 T9759 punct –,70
R2959 T9875 T9873 acomp conserved,are
R2960 T9876 T9875 prep with,conserved
R2961 T9761 T9757 pobj cM,at
R2962 T9877 T9878 amod human,chromosome
R2963 T9878 T9876 pobj chromosome,with
R2964 T9879 T9878 nummod 17,chromosome
R2965 T9880 T9868 punct .,contains
R2966 T9762 T9761 prep on,cM
R2967 T9882 T9883 nsubjpass Linkages,found
R2968 T9763 T9762 pobj chromosome,on
R2969 T9884 T9882 prep for,Linkages
R2970 T9885 T9886 amod human,RA
R2971 T9886 T9884 pobj RA,for
R2972 T9887 T9883 aux have,found
R2973 T9888 T9883 auxpass been,found
R2974 T9764 T9763 nummod 11,chromosome
R2975 T9889 T9883 prep in,found
R2976 T9890 T9891 det this,region
R2977 T9891 T9889 pobj region,in
R2978 T9892 T9891 amod particular,region
R2979 T9765 T9766 punct (,denoted
R2980 T9893 T9894 punct [,24
R2981 T9894 T9883 parataxis 24,found
R2982 T9766 T9756 parataxis denoted,detected
R2983 T9895 T9894 punct ],24
R2984 T9896 T9883 punct .,found
R2985 T9767 T9766 oprd Cia40,denoted
R2986 T9898 T9899 det Another,locus
R2987 T9899 T9901 nsubj locus,is
R2988 T9900 T9899 amod interesting,locus
R2989 T9768 T9766 punct ),denoted
R2990 T9902 T9901 attr Cia5,is
R2991 T9769 T9727 punct .,paying
R2992 T9903 T9901 prep on,is
R2993 T9904 T9905 det the,homolog
R2994 T9905 T9903 pobj homolog,on
R2995 T9771 T9772 det No,genes
R2996 T9906 T9907 compound rat,chromosome
R2997 T9907 T9905 appos chromosome,homolog
R2998 T9908 T9907 nummod 10,chromosome
R2999 T9909 T9905 punct ", ",homolog
R3000 T9772 T9775 nsubjpass genes,typed
R3001 T9910 T9911 dep which,regulates
R3002 T9911 T9905 relcl regulates,homolog
R3003 T9912 T9913 det the,severity
R3004 T9773 T9772 amod other,genes
R3005 T9913 T9911 dobj severity,regulates
R3006 T9914 T9913 prep of,severity
R3007 T9915 T9914 pobj CIA,of
R3008 T9774 T9772 compound CIA,genes
R3009 T9916 T9915 cc and,CIA
R3010 T9917 T9918 npadvmod pristane,induced
R3011 T9918 T9920 amod induced,arthritis
R3012 T9776 T9775 aux have,typed
R3013 T9919 T9918 punct -,induced
R3014 T9920 T9915 conj arthritis,CIA
R3015 T9921 T9922 punct [,25
R3016 T9922 T9901 parataxis 25,is
R3017 T9777 T9775 advmod previously,typed
R3018 T9923 T9922 punct ],25
R3019 T9924 T9901 punct .,is
R3020 T9778 T9775 auxpass been,typed
R3021 T9926 T9927 advmod Interestingly,detected
R3022 T9928 T9927 punct ", ",detected
R3023 T9929 T9927 prep from,detected
R3024 T9930 T9929 pobj studies,from
R3025 T9931 T9930 prep with,studies
R3026 T9779 T9775 prep in,typed
R3027 T9932 T9933 det the,cross
R3028 T9933 T9931 pobj cross,with
R3029 T9934 T9933 amod same,cross
R3030 T9780 T9781 det this,region
R3031 T9935 T9927 punct ", ",detected
R3032 T9936 T9927 nsubj we,detected
R3033 T9937 T9927 aux have,detected
R3034 T9781 T9779 pobj region,in
R3035 T9938 T9927 advmod previously,detected
R3036 T9939 T9940 det a,QTL
R3037 T9940 T9927 dobj QTL,detected
R3038 T9782 T9775 punct ", ",typed
R3039 T9941 T9940 amod significant,QTL
R3040 T9942 T9940 acl denoted,QTL
R3041 T9783 T9775 cc but,typed
R3042 T9784 T9785 det the,part
R3043 T9943 T9942 oprd Pregq2,denoted
R3044 T9944 T9940 prep for,QTL
R3045 T9785 T9787 nsubjpass part,known
R3046 T9945 T9946 det the,trait
R3047 T9946 T9944 pobj trait,for
R3048 T9947 T9946 punct ',trait
R3049 T9786 T9785 amod central,part
R3050 T9948 T9949 compound pregnancy,frequency
R3051 T9949 T9946 appos frequency,trait
R3052 T9950 T9927 punct ',detected
R3053 T9787 T9775 conj known,typed
R3054 T9951 T9927 prep in,detected
R3055 T9952 T9953 det the,region
R3056 T9788 T9785 prep of,part
R3057 T9953 T9951 pobj region,in
R3058 T9789 T9788 pobj chromosome,of
R3059 T9790 T9789 nummod 11,chromosome
R3060 T9791 T9787 auxpass is,known
R3061 T9954 T9955 advmod very,same
R3062 T9955 T9953 amod same,region
R3063 T9792 T9793 aux to,contain
R3064 T9956 T9953 prep as,region
R3065 T9957 T9956 pobj Cia40,as
R3066 T9958 T9959 punct (,peak
R3067 T9793 T9787 xcomp contain,known
R3068 T9959 T9927 parataxis peak,detected
R3069 T9960 T9959 prep at,peak
R3070 T9794 T9795 det a,number
R3071 T9961 T9962 quantmod 64,70
R3072 T9962 T9964 nummod 70,cM
R3073 T9795 T9793 dobj number,contain
R3074 T9796 T9795 prep of,number
R3075 T9963 T9962 punct –,70
R3076 T9964 T9960 pobj cM,at
R3077 T9965 T9964 prep on,cM
R3078 T9797 T9798 compound inflammation,loci
R3079 T9966 T9965 pobj chromosome,on
R3080 T9967 T9966 nummod 11,chromosome
R3081 T9968 T9959 punct ),peak
R3082 T9798 T9796 pobj loci,of
R3083 T9969 T9970 punct (,Liljander
R3084 T9970 T9927 meta Liljander,detected
R3085 T9799 T9798 punct ", ",loci
R3086 T9971 T9970 nmod M,Liljander
R3087 T9972 T9970 punct ", ",Liljander
R3088 T9973 T9970 nmod Sällström,Liljander
R3089 T9800 T9801 amod such,as
R3090 T9974 T9970 nmod MA,Liljander
R3091 T9975 T9970 punct ", ",Liljander
R3092 T9976 T9970 nmod Andersson,Liljander
R3093 T9801 T9798 prep as,loci
R3094 T9977 T9970 nmod S,Liljander
R3095 T9978 T9970 punct ", ",Liljander
R3096 T9802 T9801 pobj Eae22,as
R3097 T9979 T9970 nmod Wernhoff,Liljander
R3098 T9980 T9970 nmod P,Liljander
R3099 T9981 T9970 punct ", ",Liljander
R3100 T9803 T9802 punct ", ",Eae22
R3101 T9982 T9970 nmod Andersson,Liljander
R3102 T9983 T9970 nmod Å,Liljander
R3103 T9984 T9970 punct ", ",Liljander
R3104 T9804 T9802 conj Eae6b,Eae22
R3105 T9985 T9970 nmod Holmdahl,Liljander
R3106 T9986 T9970 nmod R,Liljander
R3107 T9805 T9804 punct ", ",Eae6b
R3108 T9987 T9970 punct ", ",Liljander
R3109 T9988 T9970 nmod Mattsson,Liljander
R3110 T9989 T9970 nmod R,Liljander
R3111 T9806 T9804 conj Eae23,Eae6b
R3112 T9990 T9970 punct ", ",Liljander
R3113 T9991 T9970 amod unpublished,Liljander
R3114 T9992 T9970 nmod data,Liljander
R3115 T9807 T9806 cc and,Eae23
R3116 T9993 T9970 punct ),Liljander
R3117 T9994 T9927 punct .,detected
R3118 T9808 T9806 conj Eae7,Eae23
R3119 T9996 T9997 nsubj This,means
R3120 T9809 T9810 punct [,20
R3121 T9998 T9999 mark that,contains
R3122 T9999 T9997 ccomp contains,means
R3123 T9810 T9787 parataxis 20,known
R3124 T10000 T10001 det this,region
R3125 T10001 T9999 nsubj region,contains
R3126 T10002 T9999 dobj genes,contains
R3127 T10003 T10002 acl affecting,genes
R3128 T10004 T10005 det the,incidence
R3129 T10005 T10003 dobj incidence,affecting
R3130 T9811 T9812 punct -,22
R3131 T10006 T10005 compound CIA,incidence
R3132 T10007 T10005 prep in,incidence
R3133 T10008 T10009 amod multiparous,mice
R3134 T9812 T9810 prep 22,20
R3135 T10009 T10007 pobj mice,in
R3136 T10010 T10003 prep in,affecting
R3137 T10011 T10010 pobj addition,in
R3138 T9813 T9810 punct ],20
R3139 T10012 T10011 prep to,addition
R3140 T10013 T10014 det the,rate
R3141 T9814 T9787 punct .,known
R3142 T10014 T10012 pobj rate,to
R3143 T10015 T10014 prep of,rate
R3144 T10016 T10017 amod successful,deliveries
R3145 T9816 T9817 nummod One,QTL
R3146 T10017 T10015 pobj deliveries,of
R3147 T10018 T10014 prep in,rate
R3148 T10019 T10020 amod female,mice
R3149 T10020 T10018 pobj mice,in
R3150 T9817 T9818 nsubjpass QTL,found
R3151 T10021 T9997 punct .,means
R3152 T10023 T10024 det The,rate
R3153 T9819 T9817 prep for,QTL
R3154 T10024 T10027 nsubjpass rate,defined
R3155 T10025 T10024 punct ',rate
R3156 T10026 T10024 compound pregnancy,rate
R3157 T9820 T9821 npadvmod proteoglycan,induced
R3158 T9821 T9823 amod induced,arthritis
R3159 T9822 T9821 punct -,induced
R3162 T9823 T9819 pobj arthritis,for
R3165 T9824 T9823 punct ", ",arthritis
R3169 T9825 T9826 dep which,was
R3172 T9826 T9823 relcl was,arthritis
R3175 T9827 T9828 amod female,specific
R3179 T9828 T9826 acomp specific,was
R3185 T9829 T9828 prep for,specific
R3189 T9830 T9831 compound disease,onset
R3193 T9831 T9829 pobj onset,for
R3197 T9832 T9818 punct ", ",found
R3200 T9833 T9818 aux have,found
R3202 T9834 T9818 advmod also,found
R3203 T9835 T9818 auxpass been,found
R3205 T9836 T9818 prep on,found
R3209 T9837 T9836 pobj chromosome,on
R3210 T10065 T10066 det the,gene
R3211 T10066 T10064 nsubj gene,affecting
R3212 T9838 T9837 nummod 11,chromosome
R3213 T10067 T10066 amod same,gene
R3214 T10068 T10066 punct (,gene
R3215 T10069 T10066 nmod s,gene
R3216 T9839 T9818 punct .,found
R3217 T10070 T10064 punct ),affecting
R3218 T10071 T10064 aux are,affecting
R3219 T10072 T10073 predet both,traits
R3220 T9841 T9842 mark Although,located
R3221 T10073 T10064 dobj traits,affecting
R3222 T10074 T10073 det these,traits
R3223 T10075 T10060 punct .,exclude
R3224 T9842 T9850 advcl located,is
R3225 T9843 T9844 det this,locus
R3226 T9844 T9842 nsubjpass locus,located
R3227 T9845 T9846 punct (,Pgia28
R3228 T9846 T9844 parataxis Pgia28,locus
R3229 T9847 T9846 punct ),Pgia28
R3233 T10216 T10214 ccomp influence,show
R3235 T10218 T10216 aux does,influence
R3236 T10219 T10216 neg not,influence
R3237 T10220 T10216 advmod negatively,influence
R3238 T10221 T10222 det the,incidence
R3239 T10222 T10216 dobj incidence,influence
R3240 T10223 T10222 cc or,incidence
R3241 T10224 T10222 conj severity,incidence
R3242 T10225 T10222 prep of,incidence
R3243 T10226 T10225 pobj CIA,of
R3244 T10227 T10222 acl induced,incidence
R3245 T10228 T10227 advmod later,induced
R3246 T10229 T10228 prep in,later
R3247 T10230 T10229 pobj life,in
R3248 T10231 T10214 punct .,show
R3249 T10233 T10234 advmod Furthermore,detected
R3250 T10235 T10234 punct ", ",detected
R3251 T10236 T10237 nummod two,loci
R3252 T10237 T10234 nsubjpass loci,detected
R3253 T10238 T10237 amod new,loci
R3254 T10239 T10237 acl linked,loci
R3255 T10240 T10239 prep to,linked
R3256 T10241 T10242 compound CIA,susceptibility
R3257 T10242 T10240 pobj susceptibility,to
R3258 T10243 T10234 auxpass were,detected
R3259 T10244 T10234 prep on,detected
R3260 T10245 T10244 pobj chromosome,on
R3261 T10246 T10245 nummod 11,chromosome
R3262 T10247 T10248 punct (,Cia40
R3263 T10248 T10245 parataxis Cia40,chromosome
R3264 T10249 T10248 punct ),Cia40
R3265 T10250 T10244 cc and,on
R3266 T10251 T10244 conj on,on
R3267 T10252 T10251 pobj chromosome,on
R3268 T10253 T10252 nummod 1,chromosome
R3269 T10254 T10234 punct .,detected
R3270 T10256 T10257 nsubj We,detected
R3271 T10258 T10257 prep on,detected
R3272 T10259 T10258 pobj chromosome,on
R3273 T10260 T10259 nummod 13,chromosome
R3274 T10261 T10262 det a,locus
R3275 T10262 T10257 dobj locus,detected
R3276 T10263 T10262 acl associated,locus
R3277 T10264 T10263 prep with,associated
R3278 T10265 T10266 amod anti-CII,titers
R3279 T10266 T10264 pobj titers,with
R3280 T10267 T10262 punct ", ",locus
R3281 T10268 T10269 dep which,is
R3282 T10269 T10262 relcl is,locus
R3283 T10270 T10269 advmod probably,is
R3284 T10271 T10272 det the,same
R3285 T10272 T10269 attr same,is
R3286 T10273 T10272 prep as,same
R3287 T10274 T10275 det the,Cia28
R3288 T10275 T10273 pobj Cia28,as
R3289 T10276 T10277 advmod recently,reported
R3290 T10277 T10275 amod reported,Cia28
R3291 T10278 T10279 punct [,19
R3292 T10279 T10257 parataxis 19,detected
R3293 T10280 T10279 punct ],19
R3294 T10281 T10257 punct .,detected
R1792 T5627 T5626 punct -,Whitney
R1778 T5610 T5611 amod Statistical,analysis
R1779 T5613 T5614 amod Statistical,comparison
R1780 T5614 T5615 nsubjpass comparison,performed
R1781 T5616 T5614 prep between,comparison
R1782 T5617 T5618 det the,groups
R1783 T5618 T5616 pobj groups,between
R1784 T5619 T5618 amod different,groups
R1785 T5620 T5618 amod experimental,groups
R1786 T5621 T5615 auxpass was,performed
R1787 T5622 T5615 advcl using,performed
R1788 T5623 T5624 det the,test
R1789 T5624 T5622 dobj test,using
R1790 T5625 T5626 compound Mann,Whitney
R1791 T5626 T5624 compound Whitney,test
R1793 T5628 T5624 compound U,test
R1794 T5629 T5624 cc or,test
R1795 T5630 T5631 poss Student,test
R1796 T5631 T5624 conj test,test
R1797 T5632 T5630 case 's,Student
R1798 T5633 T5631 amod unpaired,test
R1799 T5634 T5631 compound t,test
R1800 T5635 T5615 punct .,performed
R3230 T10212 T10213 poss Our,results
R3231 T10213 T10214 nsubj results,show
R3232 T10215 T10216 mark that,influence
R3234 T10217 T10216 nsubj multiparity,influence
R1745 T5532 T5531 amod purified,antibodies
R1746 T5533 T5531 nmod mouse,antibodies
R1747 T5534 T5531 amod anti-CII,antibodies
R1756 T5543 T5541 cc and,positive
R1757 T5544 T5541 conj negative,positive
R760 T2738 T2737 punct /,N
R800 T2780 T2778 punct ×,B10Q
R801 T2781 T2782 compound NFR,N
R804 T2784 T2778 punct ),B10Q
R812 T2793 T2792 punct /,N
R857 T2840 T2839 compound FOR,R36
R861 T2844 T2843 amod breeding,food
R907 T2892 T2893 compound Laboratory,Animal
R908 T2893 T2891 compound Animal,Sciences
R1142 T3832 T3831 punct -,point
R1 T533 T531 prep of,Identification
R2 T534 T535 npadvmod collagen,induced
R7 T539 T531 prep in,Identification
R8 T540 T541 amod aged,mice
R12 T546 T547 npadvmod Collagen,induced
R15 T549 T550 nsubj arthritis,is
R16 T551 T549 prep in,arthritis
R17 T552 T551 pobj mice,in
R18 T553 T550 attr one,is
R19 T554 T553 prep of,one
R20 T555 T556 det the,models
R27 T562 T553 punct ", ",one
R28 T563 T553 prep with,one
R29 T564 T565 amod many,similarities
R30 T565 T563 pobj similarities,with
R31 T566 T565 prep to,similarities
R32 T567 T568 amod rheumatoid,arthritis
R33 T568 T566 pobj arthritis,to
R34 T569 T550 punct .,is
R35 T571 T572 mark Since,is
R38 T574 T576 amod induced,arthritis
R41 T578 T579 det a,disease
R45 T582 T577 expl there,is
R46 T583 T584 det a,need
R47 T584 T577 attr need,is
R48 T585 T584 prep for,need
R49 T586 T585 pobj identification,for
R50 T587 T586 prep of,identification
R51 T588 T589 amod several,genes
R55 T592 T589 amod controlling,genes
R57 T594 T577 punct .,is
R58 T596 T597 mark Because,affects
R63 T602 T603 amod aged,women
R64 T603 T597 dobj women,affects
R65 T604 T601 punct ", ",identified
R66 T605 T601 nsubj we,identified
R67 T606 T601 aux have,identified
R68 T607 T601 prep in,identified
R69 T608 T609 det the,study
R72 T611 T612 amod new,regions
R75 T614 T612 amod critical,regions
R76 T615 T614 prep for,critical
R77 T616 T617 npadvmod collagen,induced
R80 T619 T615 pobj arthritis,for
R81 T620 T601 prep by,identified
R82 T621 T620 pcomp studying,by
R83 T622 T623 amod aged,mice
R86 T625 T623 prep of,mice
R87 T626 T627 det a,cross
R88 T627 T625 pobj cross,of
R89 T628 T627 prep between,cross
R90 T629 T630 compound NFR,N
R93 T632 T630 cc and,N
R94 T633 T630 conj B10.Q,N
R95 T634 T635 punct (,haplotype
R98 T637 T635 compound 2q,haplotype
R100 T639 T635 punct ),haplotype
R101 T640 T601 punct .,identified
R102 T642 T643 det The,mice
R103 T643 T644 nsubj mice,had
R104 T645 T643 prep in,mice
R105 T646 T647 det the,study
R108 T649 T650 amod different,histories
R111 T652 T650 punct ", ",histories
R112 T653 T654 dep which,affect
R117 T658 T659 det the,onset
R118 T659 T654 dobj onset,affect
R119 T660 T659 punct ", ",onset
R120 T661 T659 conj incidence,onset
R121 T662 T661 cc or,incidence
R122 T663 T661 conj severity,incidence
R123 T664 T659 prep of,onset
R124 T665 T666 det the,disease
R125 T666 T664 pobj disease,of
R126 T667 T644 punct .,had
R127 T669 T670 det A,total
R128 T670 T671 nsubjpass total,used
R129 T672 T670 prep of,total
R130 T673 T674 nummod 200,mice
R133 T676 T671 auxpass were,used
R134 T677 T671 prep in,used
R135 T678 T679 det a,screening
R139 T682 T679 amod wide,screening
R141 T684 T679 prep with,screening
R142 T685 T686 nummod 125,markers
R145 T688 T671 punct .,used
R146 T690 T691 nsubj We,found
R147 T692 T693 nummod one,locus
R153 T698 T693 acl affecting,locus
R154 T699 T700 det the,incidence
R157 T702 T700 punct ", ",incidence
R158 T703 T700 conj severity,incidence
R159 T704 T703 cc and,severity
R160 T705 T703 conj day,severity
R161 T706 T705 prep of,day
R162 T707 T706 pobj onset,of
R163 T708 T691 prep on,found
R164 T709 T708 pobj chromosome,on
R165 T710 T709 nummod 11,chromosome
R166 T711 T712 punct (,denoted
R167 T712 T709 parataxis denoted,chromosome
R168 T713 T712 oprd Cia40,denoted
R169 T714 T712 punct ),denoted
R170 T715 T709 punct ", ",chromosome
R171 T716 T717 dep which,colocalizes
R172 T717 T709 relcl colocalizes,chromosome
R173 T718 T717 prep with,colocalizes
R174 T719 T720 det a,failure
R179 T724 T691 punct .,found
R180 T726 T727 advmod Furthermore,identified
R181 T728 T727 punct ", ",identified
R182 T729 T730 det a,locus
R186 T733 T730 prep of,locus
R187 T734 T735 amod suggestive,significance
R188 T735 T733 pobj significance,of
R189 T736 T730 acl associated,locus
R190 T737 T736 prep with,associated
R191 T738 T739 det the,incidence
R192 T739 T737 pobj incidence,with
R193 T740 T739 punct ", ",incidence
R194 T741 T739 conj severity,incidence
R195 T742 T741 cc and,severity
R196 T743 T741 conj day,severity
R197 T744 T743 prep of,day
R198 T745 T744 pobj onset,of
R199 T746 T727 auxpass was,identified
R200 T747 T727 prep on,identified
R201 T748 T747 pobj chromosome,on
R202 T749 T748 nummod 1,chromosome
R203 T750 T727 punct .,identified
R204 T752 T753 advmod Finally,identified
R205 T754 T753 punct ", ",identified
R206 T755 T756 det a,locus
R212 T761 T756 acl associated,locus
R213 T762 T761 prep with,associated
R214 T763 T764 nmod collagen,titers
R219 T768 T753 auxpass was,identified
R220 T769 T753 prep on,identified
R221 T770 T769 pobj chromosome,on
R222 T771 T770 nummod 13,chromosome
R223 T772 T753 punct .,identified
R224 T774 T775 det This,study
R225 T775 T776 nsubj study,indicates
R226 T777 T778 mark that,control
R229 T780 T778 nsubj loci,control
R231 T782 T778 dobj arthritis,control
R232 T783 T778 prep in,control
R233 T784 T785 amod aged,females
R236 T787 T778 punct ", ",control
R237 T788 T778 cc and,control
R238 T789 T790 mark that,coincides
R246 T797 T790 prep with,coincides
R247 T798 T799 compound pregnancy,failure
R248 T799 T797 pobj failure,with
R249 T800 T776 punct .,indicates
R1289 T4789 T4788 punct -,labeled
R1313 T4814 T4813 punct -,seven
R1345 T4849 T4848 punct -,well
R1348 T4852 T4851 punct -,bottom
R1403 T4907 T4906 nummod 10,pmol
R1632 T5152 T5151 amod significant,threshold
R250 T1847 T1848 det The,similarities
R251 T1848 T1849 nsubj similarities,are
R252 T1850 T1848 prep between,similarities
R253 T1851 T1852 amod rheumatoid,arthritis
R254 T1852 T1850 pobj arthritis,between
R255 T1853 T1852 punct (,arthritis
R256 T1854 T1852 appos RA,arthritis
R257 T1855 T1852 punct ),arthritis
R258 T1856 T1852 prep in,arthritis
R259 T1857 T1856 pobj man,in
R260 T1858 T1852 cc and,arthritis
R261 T1859 T1860 npadvmod collagen,induced
R264 T1862 T1852 conj arthritis,arthritis
R265 T1863 T1862 punct (,arthritis
R266 T1864 T1862 appos CIA,arthritis
R267 T1865 T1862 punct ),arthritis
R268 T1866 T1862 prep in,arthritis
R269 T1867 T1866 pobj mice,in
R270 T1868 T1869 advmod well,established
R271 T1869 T1849 acomp established,are
R272 T1870 T1849 punct ", ",are
R273 T1871 T1872 mark although,exist
R278 T1876 T1874 pobj pattern,in
R280 T1878 T1879 punct [,1
R281 T1879 T1849 parataxis 1,are
R282 T1880 T1881 punct -,3
R283 T1881 T1879 prep 3,1
R284 T1882 T1879 punct ],1
R285 T1883 T1849 punct .,are
R286 T1885 T1886 acomp Characteristic,is
R287 T1887 T1885 prep of,Characteristic
R288 T1888 T1887 pobj RA,of
R289 T1889 T1890 det the,fact
R290 T1890 T1886 nsubj fact,is
R291 T1891 T1892 mark that,are
R297 T1897 T1898 advmod more,susceptible
R298 T1898 T1892 acomp susceptible,are
R299 T1899 T1898 prep to,susceptible
R300 T1900 T1901 det the,disease
R301 T1901 T1899 pobj disease,to
R302 T1902 T1898 prep than,susceptible
R303 T1903 T1902 pobj men,than
R304 T1904 T1905 punct [,4
R305 T1905 T1886 parataxis 4,is
R306 T1906 T1905 punct ],4
R307 T1907 T1886 punct .,is
R308 T1909 T1910 nsubjpass It,reported
R309 T1911 T1910 aux has,reported
R310 T1912 T1910 advmod also,reported
R311 T1913 T1910 auxpass been,reported
R312 T1914 T1915 mark that,exhibit
R322 T1924 T1922 nummod 31,females
R328 T1930 T1931 amod clinical,remission
R329 T1931 T1915 dobj remission,exhibit
R330 T1932 T1915 prep during,exhibit
R331 T1933 T1934 det the,course
R332 T1934 T1932 pobj course,during
R333 T1935 T1934 prep of,course
R334 T1936 T1935 pobj pregnancy,of
R335 T1937 T1938 punct [,5
R336 T1938 T1910 parataxis 5,reported
R337 T1939 T1938 punct ],5
R338 T1940 T1910 punct .,reported
R339 T1942 T1943 prep On,suggested
R340 T1944 T1945 det the,hand
R343 T1947 T1943 punct ", ",suggested
R344 T1948 T1943 nsubjpass it,suggested
R345 T1949 T1943 aux has,suggested
R346 T1950 T1943 auxpass been,suggested
R347 T1951 T1952 mark that,postponed
R354 T1958 T1952 agent by,postponed
R355 T1959 T1958 pobj parity,by
R356 T1960 T1943 punct .,suggested
R357 T1962 T1963 det The,risk
R358 T1963 T1964 nsubjpass risk,reduced
R359 T1965 T1963 prep of,risk
R360 T1966 T1965 pobj onset,of
R361 T1967 T1964 auxpass is,reduced
R362 T1968 T1964 prep during,reduced
R363 T1969 T1968 pobj pregnancy,during
R364 T1970 T1964 punct ", ",reduced
R365 T1971 T1972 mark while,increased
R369 T1975 T1973 pobj year,in
R377 T1983 T1984 punct [,7
R381 T1987 T1984 punct ],7
R382 T1988 T1964 punct .,reduced
R383 T1990 T1991 det The,results
R384 T1991 T1992 nsubj results,indicate
R385 T1993 T1991 prep of,results
R386 T1994 T1995 det a,study
R389 T1997 T1995 prep of,study
R390 T1998 T1997 pobj RA,of
R391 T1999 T1998 prep in,RA
R392 T2000 T1999 pobj women,in
R393 T2001 T1992 punct ", ",indicate
R394 T2002 T1992 advmod however,indicate
R395 T2003 T1992 punct ", ",indicate
R396 T2004 T2005 mark that,increase
R402 T2010 T2011 det the,incidence
R403 T2011 T2005 dobj incidence,increase
R404 T2012 T2011 prep of,incidence
R405 T2013 T2014 det the,disease
R406 T2014 T2012 pobj disease,of
R407 T2015 T2005 advmod later,increase
R408 T2016 T2015 prep in,later
R409 T2017 T2016 pobj life,in
R410 T2018 T2019 punct [,8
R411 T2019 T1992 parataxis 8,indicate
R412 T2020 T2019 punct ],8
R413 T2021 T1992 punct .,indicate
R414 T2023 T2024 amod Adequate,models
R417 T2027 T2028 amod useful,tools
R418 T2028 T2026 attr tools,are
R419 T2029 T2028 prep for,tools
R420 T2030 T2031 det the,identification
R421 T2031 T2029 pobj identification,for
R422 T2032 T2031 prep of,identification
R423 T2033 T2032 pobj genes,of
R424 T2034 T2033 acl involved,genes
R425 T2035 T2034 prep in,involved
R426 T2036 T2037 amod complex,diseases
R429 T2039 T2026 punct .,are
R430 T2041 T2042 nsubj CIA,shares
R431 T2043 T2041 prep in,CIA
R432 T2044 T2043 pobj mice,in
R433 T2045 T2046 preconj both,immunological
R434 T2046 T2047 amod immunological,characteristics
R438 T2050 T2042 prep with,shares
R439 T2051 T2052 amod human,RA
R440 T2052 T2050 pobj RA,with
R441 T2053 T2042 cc and,shares
R442 T2054 T2042 conj is,shares
R443 T2055 T2054 attr one,is
R444 T2056 T2055 prep of,one
R445 T2057 T2058 det the,models
R449 T2061 T2058 prep for,models
R450 T2062 T2063 det the,identification
R451 T2063 T2061 pobj identification,for
R452 T2064 T2063 prep of,identification
R453 T2065 T2064 pobj genes,of
R454 T2066 T2065 cc and,genes
R455 T2067 T2065 conj mechanisms,genes
R456 T2068 T2065 acl involved,genes
R457 T2069 T2068 prep in,involved
R458 T2070 T2069 pobj arthritis,in
R459 T2071 T2042 punct .,shares
R460 T2073 T2074 det The,incidence
R461 T2074 T2075 nsubj incidence,is
R462 T2076 T2074 prep of,incidence
R463 T2077 T2076 pobj CIA,of
R464 T2078 T2079 npadvmod sex,dependent
R465 T2079 T2075 acomp dependent,is
R466 T2080 T2075 punct ", ",is
R467 T2081 T2075 prep like,is
R468 T2082 T2083 det the,incidence
R469 T2083 T2081 pobj incidence,like
R470 T2084 T2083 prep in,incidence
R471 T2085 T2084 pobj RA,in
R472 T2086 T2075 punct ", ",is
R473 T2087 T2088 mark although,lead
R484 T2098 T2088 prep to,lead
R485 T2099 T2100 preconj both,male
R486 T2100 T2101 amod male,predominance
R490 T2104 T2075 punct .,is
R491 T2106 T2107 amod Male,mice
R492 T2107 T2108 nsubjpass mice,affected
R493 T2109 T2108 auxpass are,affected
R494 T2110 T2111 advmod more,often
R495 T2111 T2108 advmod often,affected
R496 T2112 T2108 prep than,affected
R497 T2113 T2112 pobj females,than
R498 T2114 T2108 punct .,affected
R499 T2116 T2117 compound Gender,differences
R500 T2117 T2118 nsubj differences,are
R501 T2119 T2117 prep in,differences
R502 T2120 T2121 compound CIA,susceptibility
R503 T2121 T2119 pobj susceptibility,in
R504 T2122 T2118 acomp dependent,are
R505 T2123 T2122 prep on,dependent
R506 T2124 T2125 amod many,factors
R507 T2125 T2123 pobj factors,on
R508 T2126 T2125 punct ", ",factors
R509 T2127 T2125 prep including,factors
R510 T2128 T2129 amod genetic,influences
R516 T2134 T2135 punct [,9
R517 T2135 T2118 parataxis 9,are
R518 T2136 T2135 punct ],9
R519 T2137 T2118 punct .,are
R520 T2139 T2140 advmod However,are
R521 T2141 T2140 punct ", ",are
R522 T2142 T2143 amod isolated,factors
R523 T2143 T2140 nsubj factors,are
R524 T2144 T2145 advmod remarkably,consistent
R525 T2145 T2140 acomp consistent,are
R526 T2146 T2140 prep between,are
R527 T2147 T2146 pobj RA,between
R528 T2148 T2147 cc and,RA
R529 T2149 T2150 det the,models
R533 T2153 T2154 punct [,9
R537 T2157 T2154 punct ],9
R538 T2158 T2140 punct .,are
R539 T2160 T2161 nsubj Pregnancy,causes
R540 T2162 T2160 prep in,Pregnancy
R541 T2163 T2162 pobj mice,in
R542 T2164 T2161 punct ", ",causes
R543 T2165 T2161 prep like,causes
R544 T2166 T2165 pobj pregnancy,like
R545 T2167 T2166 prep in,pregnancy
R546 T2168 T2167 pobj women,in
R547 T2169 T2161 punct ", ",causes
R548 T2170 T2161 advmod normally,causes
R549 T2171 T2161 dobj remission,causes
R550 T2172 T2171 prep of,remission
R551 T2173 T2172 pobj arthritis,of
R552 T2174 T2175 punct [,10
R556 T2178 T2175 punct ],10
R557 T2179 T2161 punct ", ",causes
R558 T2180 T2181 mark while,occurs
R562 T2184 T2181 advmod postpartum,occurs
R563 T2185 T2186 punct [,11
R569 T2191 T2186 punct ],11
R570 T2192 T2161 punct .,causes
R571 T2194 T2195 npadvmod Pregnancy,induced
R574 T2197 T2198 nsubj remission,appears
R575 T2199 T2197 prep of,remission
R576 T2200 T2199 pobj CIA,of
R577 T2201 T2197 prep in,remission
R578 T2202 T2201 pobj mice,in
R579 T2203 T2204 aux to,caused
R582 T2206 T2204 agent by,caused
R583 T2207 T2208 det the,increase
R584 T2208 T2206 pobj increase,by
R585 T2209 T2208 prep in,increase
R586 T2210 T2211 compound estrogen,levels
R587 T2211 T2209 pobj levels,in
R588 T2212 T2198 punct ", ",appears
R589 T2213 T2214 mark while,explained
R592 T2216 T2214 nsubjpass exacerbation,explained
R596 T2220 T2214 agent by,explained
R597 T2221 T2222 det the,drop
R600 T2224 T2222 prep in,drop
R601 T2225 T2224 pobj estrogen,in
R602 T2226 T2227 punct [,10
R603 T2227 T2222 parataxis 10,drop
R604 T2228 T2227 punct ],10
R605 T2229 T2222 punct ", ",drop
R606 T2230 T2231 advmod possibly,together
R607 T2231 T2222 advmod together,drop
R608 T2232 T2231 prep with,together
R609 T2233 T2234 amod increased,levels
R612 T2236 T2237 punct [,11
R613 T2237 T2231 parataxis 11,together
R614 T2238 T2237 punct ],11
R615 T2239 T2198 punct .,appears
R616 T2241 T2242 prep To,affects
R621 T2246 T2242 nsubj history,affects
R626 T2252 T2253 det the,incidence
R627 T2253 T2242 dobj incidence,affects
R628 T2254 T2253 prep of,incidence
R629 T2255 T2254 pobj CIA,of
R630 T2256 T2253 advmod later,incidence
R631 T2257 T2256 prep in,later
R632 T2258 T2257 pobj life,in
R633 T2259 T2251 aux has,studied
R634 T2260 T2251 punct ", ",studied
R635 T2261 T2251 prep to,studied
R636 T2262 T2263 poss our,knowledge
R637 T2263 T2261 pobj knowledge,to
R638 T2264 T2251 punct ", ",studied
R639 T2265 T2251 neg not,studied
R640 T2266 T2251 advmod previously,studied
R641 T2267 T2251 auxpass been,studied
R642 T2268 T2251 punct .,studied
R643 T2270 T2271 advmod Importantly,occurs
R644 T2272 T2271 punct ", ",occurs
R645 T2273 T2271 nsubj RA,occurs
R646 T2274 T2271 advmod predominantly,occurs
R647 T2275 T2271 prep in,occurs
R648 T2276 T2275 pobj women,in
R649 T2277 T2276 punct ", ",women
R650 T2278 T2279 dep many,had
R655 T2283 T2284 amod several,children
R656 T2284 T2279 dobj children,had
R657 T2285 T2271 punct ", ",occurs
R658 T2286 T2271 cc and,occurs
R659 T2287 T2288 nsubj it,is
R660 T2288 T2271 conj is,occurs
R661 T2289 T2288 advmod therefore,is
R662 T2290 T2288 acomp appropriate,is
R663 T2291 T2292 aux to,mimic
R666 T2294 T2295 det this,situation
R667 T2295 T2292 dobj situation,mimic
R668 T2296 T2292 advcl using,mimic
R669 T2297 T2298 compound animal,models
R670 T2298 T2296 dobj models,using
R671 T2299 T2288 punct .,is
R672 T2301 T2302 prep In,analyzed
R673 T2303 T2304 det the,paper
R676 T2306 T2302 nsubj we,analyzed
R677 T2307 T2302 aux have,analyzed
R678 T2308 T2309 amod female,mice
R679 T2309 T2302 dobj mice,analyzed
R680 T2310 T2311 dep that,undergone
R684 T2314 T2315 det a,study
R687 T2317 T2318 punct (,Liljander
R688 T2318 T2302 meta Liljander,analyzed
R689 T2319 T2318 nmod M,Liljander
R690 T2320 T2318 punct ", ",Liljander
R691 T2321 T2318 nmod Sällström,Liljander
R692 T2322 T2318 nmod MA,Liljander
R693 T2323 T2318 punct ", ",Liljander
R694 T2324 T2318 nmod Andersson,Liljander
R695 T2325 T2318 nmod S,Liljander
R696 T2326 T2318 punct ", ",Liljander
R697 T2327 T2318 nmod Wernhoff,Liljander
R698 T2328 T2318 nmod P,Liljander
R699 T2329 T2318 punct ", ",Liljander
R700 T2330 T2318 nmod Andersson,Liljander
R701 T2331 T2318 nmod Å,Liljander
R702 T2332 T2318 punct ", ",Liljander
R703 T2333 T2318 nmod Holmdahl,Liljander
R704 T2334 T2318 nmod R,Liljander
R705 T2335 T2318 punct ", ",Liljander
R706 T2336 T2318 nmod Mattsson,Liljander
R707 T2337 T2318 nmod R,Liljander
R708 T2338 T2318 punct ", ",Liljander
R709 T2339 T2318 amod unpublished,Liljander
R710 T2340 T2318 nmod data,Liljander
R711 T2341 T2318 punct ),Liljander
R712 T2342 T2302 punct .,analyzed
R713 T2344 T2345 det A,total
R714 T2345 T2346 nsubjpass total,used
R715 T2347 T2345 prep of,total
R716 T2348 T2349 nummod 200,mice
R719 T2351 T2352 punct (,months
R722 T2354 T2352 prep of,months
R723 T2355 T2354 pobj age,of
R724 T2356 T2352 punct ),months
R725 T2357 T2349 prep of,mice
R726 T2358 T2359 det the,backcross
R729 T2361 T2359 prep between,backcross
R730 T2362 T2363 compound NFR,N
R733 T2365 T2363 cc and,N
R734 T2366 T2367 compound C57BL,B10.Q
R737 T2369 T2370 punct (,B10.Q
R738 T2370 T2367 parataxis B10.Q,B10.Q
R739 T2371 T2370 punct ),B10.Q
R740 T2372 T2346 auxpass were,used
R741 T2373 T2374 aux to,analyze
R742 T2374 T2346 advcl analyze,used
R743 T2375 T2376 det the,control
R746 T2378 T2376 prep of,control
R747 T2379 T2378 pobj CIA,of
R748 T2380 T2374 prep in,analyze
R749 T2381 T2382 amod aged,females
R750 T2382 T2380 pobj females,in
R751 T2383 T2382 prep with,females
R752 T2384 T2385 det a,history
R755 T2387 T2346 punct .,used
R2240 T9024 T9023 punct -,susceptible
R2247 T9031 T9030 punct /,N
R2259 T9044 T9043 punct /,N
R2272 T9058 T9057 punct -,2q
R2360 T9149 T9148 amod parental,strains
R2376 T9166 T9165 nummod II,A
R2490 T9290 T9289 amod multiparous,mice
R2510 T9312 T9311 punct /,N
R2645 T9453 T9443 punct ", ",remission
R2909 T9733 T9734 mark since,is
R2926 T9750 T9751 det the,QTL
R2928 T9751 T9749 pobj QTL,to
R3160 T10028 T10024 punct ',rate
R3161 T10029 T10024 prep in,rate
R3163 T10030 T10029 pobj mice,in
R3164 T10031 T10027 auxpass is,defined
R3166 T10032 T10027 prep as,defined
R3167 T10033 T10034 amod successful,pregnancies
R3168 T10034 T10032 pobj pregnancies,as
R3170 T10035 T10034 prep per,pregnancies
R3171 T10036 T10037 amod detected,plug
R3173 T10037 T10035 pobj plug,per
R3174 T10038 T10037 amod vaginal,plug
R3176 T10039 T10034 punct ", ",pregnancies
R3177 T10040 T10041 det a,phenotype
R3178 T10041 T10034 appos phenotype,pregnancies
R3180 T10042 T10041 acl associated,phenotype
R3181 T10043 T10042 prep with,associated
R3182 T10044 T10045 amod early,failure
R3183 T10045 T10043 pobj failure,with
R3184 T10046 T10045 compound pregnancy,failure
R3186 T10047 T10045 punct ", ",failure
R3187 T10048 T10049 dep which,have
R3188 T10049 T10045 relcl have,failure
R3190 T10050 T10049 prep in,have
R3191 T10051 T10050 pobj turn,in
R3192 T10052 T10049 advmod possibly,have
R3194 T10053 T10049 aux could,have
R3195 T10054 T10055 det an,cause
R3196 T10055 T10049 dobj cause,have
R3198 T10056 T10055 amod inflammatory,cause
R3199 T10057 T10027 punct .,defined
R3201 T10059 T10060 nsubj We,exclude
R3204 T10061 T10060 aux can,exclude
R3206 T10062 T10060 neg not,exclude
R3207 T10063 T10064 mark that,affecting
R3208 T10064 T10060 ccomp affecting,exclude