PMC:1524773 / 53074-54109 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1524773","sourcedb":"PMC","sourceid":"1524773","source_url":"https://www.ncbi.nlm.nih.gov/pmc/1524773","text":"This basic variant yields good results but it can be improved by the following procedure: For every pair A, B of cliques compute the intersection A ⋂ B. If there are many intervals in this intersection set, e.g., |A ⋂ B| \u003e 3, and only a few intervals that are not, the intersection of the two cliques represents intervals that are very similar to each other. These intervals would be in one clique if the c-value would have been more restrictive, i.e., larger. But due to the low c-value, there are other intervals to the left and right of the intervals in the intersection set that interact with the intervals in A ⋂ B but not with each other. As discussed above, a low c-value has the advantage of keeping good clusters together, and thus c should not be too high in the beginning. However, the effect of a larger c-value can be mimicked by adding those intersection sets to the list L in the first step of the above described mechanism and to allow the intervals to assign them to any set in L be it a clique or an intersection set.","tracks":[]}