PMC:1524735 / 19062-20285 JSONTXT

{"project":"2_test","denotations":[{"id":"16764722-16539218-140959303","span":{"begin":118,"end":119},"obj":"16539218"},{"id":"16764722-11981294-140959304","span":{"begin":847,"end":848},"obj":"11981294"},{"id":"16764722-10701626-140959305","span":{"begin":1219,"end":1221},"obj":"10701626"}],"text":"Medical complications\nMost study drugs raise blood pressure and may place users at risk for heart attacks and stroke [5,6]. For example, side effects may include irregular heartbeat and very high blood pressure [1,15]. Thus, use is contraindicated if one has a history of high blood pressure or other cardiovascular-related concerns. In addition, use is contraindicated among those suffering from psychiatric conditions including severe anxiety, glaucoma, motor tics (or Tourette's syndrome), psychotic conditions, depression, a seizure disorder, or a history of drug abuse. Also, one should not use prescription stimulants if one has experienced a narrowing of ones gastrointestinal tract or a damaged liver. Finally, use also is contraindicated if one is taking other prescribed drugs particularly monoamine oxidase (MAO) inhibitors [e.g., see [2,34]].\nIntravenous use of prescription stimulants is particularly dangerous. In particular, intravenous (IV) abuse of methylphenidate may result in talcosis. Talcosis is a reaction to talc, a filler and lubricant in methylphenidate and other oral medication. This inflammation reaction occurs in the lungs and related consequences include lower lobe panacinar emphysema [35]."}

{"project":"NEUROSES","denotations":[{"id":"T439","span":{"begin":33,"end":38},"obj":"CHEBI_23888"},{"id":"T440","span":{"begin":563,"end":567},"obj":"CHEBI_23888"},{"id":"T441","span":{"begin":781,"end":786},"obj":"CHEBI_23888"},{"id":"T442","span":{"begin":202,"end":210},"obj":"PATO_0001025"},{"id":"T443","span":{"begin":283,"end":291},"obj":"PATO_0001025"},{"id":"T444","span":{"begin":191,"end":195},"obj":"PATO_0000469"},{"id":"T445","span":{"begin":272,"end":276},"obj":"PATO_0000469"},{"id":"T446","span":{"begin":695,"end":702},"obj":"PATO_0001167"},{"id":"T447","span":{"begin":800,"end":809},"obj":"CHEBI_63534"},{"id":"T448","span":{"begin":800,"end":809},"obj":"CHEBI_25375"},{"id":"T449","span":{"begin":824,"end":834},"obj":"CHEBI_35222"},{"id":"T450","span":{"begin":966,"end":981},"obj":"CHEBI_6887"},{"id":"T451","span":{"begin":1064,"end":1079},"obj":"CHEBI_6887"},{"id":"T452","span":{"begin":1032,"end":1036},"obj":"CHEBI_32178"},{"id":"T453","span":{"begin":1040,"end":1046},"obj":"CHEBI_75324"},{"id":"T454","span":{"begin":1040,"end":1046},"obj":"CHEBI_78004"},{"id":"T455","span":{"begin":515,"end":525},"obj":"PM3425"},{"id":"T456","span":{"begin":515,"end":525},"obj":"PM3425"}],"text":"Medical complications\nMost study drugs raise blood pressure and may place users at risk for heart attacks and stroke [5,6]. For example, side effects may include irregular heartbeat and very high blood pressure [1,15]. Thus, use is contraindicated if one has a history of high blood pressure or other cardiovascular-related concerns. In addition, use is contraindicated among those suffering from psychiatric conditions including severe anxiety, glaucoma, motor tics (or Tourette's syndrome), psychotic conditions, depression, a seizure disorder, or a history of drug abuse. Also, one should not use prescription stimulants if one has experienced a narrowing of ones gastrointestinal tract or a damaged liver. Finally, use also is contraindicated if one is taking other prescribed drugs particularly monoamine oxidase (MAO) inhibitors [e.g., see [2,34]].\nIntravenous use of prescription stimulants is particularly dangerous. In particular, intravenous (IV) abuse of methylphenidate may result in talcosis. Talcosis is a reaction to talc, a filler and lubricant in methylphenidate and other oral medication. This inflammation reaction occurs in the lungs and related consequences include lower lobe panacinar emphysema [35]."}