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Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T3650","span":{"begin":755,"end":765},"obj":"CL:0000855"},{"id":"T3649","span":{"begin":671,"end":678},"obj":"UBERON:0001853"},{"id":"T3648","span":{"begin":653,"end":658},"obj":"PR:000013043"},{"id":"T3647","span":{"begin":589,"end":592},"obj":"CHEBI:52029"},{"id":"T3646","span":{"begin":541,"end":545},"obj":"NCBITaxon:10088"},{"id":"T3645","span":{"begin":457,"end":466},"obj":"UBERON:0000483"},{"id":"T3644","span":{"begin":438,"end":447},"obj":"UBERON:0006798"},{"id":"T3643","span":{"begin":408,"end":415},"obj":"UBERON:0001854"},{"id":"T3642","span":{"begin":396,"end":403},"obj":"UBERON:0001853"},{"id":"T3641","span":{"begin":330,"end":346},"obj":"UBERON:0001843"},{"id":"T3640","span":{"begin":301,"end":310},"obj":"UBERON:0000483"},{"id":"T3639","span":{"begin":295,"end":300},"obj":"UBERON:0000025"},{"id":"T3638","span":{"begin":272,"end":287},"obj":"CL:0000101"},{"id":"T3637","span":{"begin":169,"end":174},"obj":"PR:000013043"},{"id":"T3636","span":{"begin":52,"end":72},"obj":"UBERON:0006932"},{"id":"T3635","span":{"begin":35,"end":43},"obj":"UBERON:0006798"}],"text":"Very few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3679","span":{"begin":301,"end":310},"obj":"UBERON:0000483"},{"id":"T3678","span":{"begin":295,"end":300},"obj":"UBERON:0000025"},{"id":"T3677","span":{"begin":272,"end":287},"obj":"CL:0000101"},{"id":"T3676","span":{"begin":272,"end":279},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T3675","span":{"begin":261,"end":271},"obj":"UBERON_EXT:vestibule_or_vestibular_system"},{"id":"T3674","span":{"begin":180,"end":187},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T3673","span":{"begin":175,"end":179},"obj":"SO_EXT:sequence_nullness"},{"id":"T3672","span":{"begin":169,"end":174},"obj":"PR_EXT:000013043"},{"id":"T3671","span":{"begin":145,"end":156},"obj":"GO_UBERON_EXT:innervation_entity_or_process"},{"id":"T3670","span":{"begin":52,"end":72},"obj":"UBERON:0006932"},{"id":"T3669","span":{"begin":35,"end":43},"obj":"UBERON:0006798"},{"id":"T3696","span":{"begin":760,"end":765},"obj":"CL_GO_EXT:cell"},{"id":"T3695","span":{"begin":755,"end":765},"obj":"CL:0000855"},{"id":"T3694","span":{"begin":705,"end":710},"obj":"CL_GO_EXT:cell"},{"id":"T3693","span":{"begin":671,"end":678},"obj":"UBERON:0001853"},{"id":"T3692","span":{"begin":664,"end":670},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T3691","span":{"begin":659,"end":663},"obj":"SO_EXT:sequence_nullness"},{"id":"T3690","span":{"begin":653,"end":658},"obj":"PR_EXT:000013043"},{"id":"T3689","span":{"begin":596,"end":601},"obj":"CL_GO_EXT:cell"},{"id":"T3688","span":{"begin":589,"end":592},"obj":"CHEBI:52029"},{"id":"T3687","span":{"begin":575,"end":583},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T3686","span":{"begin":566,"end":574},"obj":"CL_GO_EXT:cell"},{"id":"T3685","span":{"begin":541,"end":545},"obj":"NCBITaxon:10088"},{"id":"T3684","span":{"begin":457,"end":466},"obj":"UBERON:0000483"},{"id":"T3683","span":{"begin":438,"end":447},"obj":"UBERON:0006798"},{"id":"T3682","span":{"begin":408,"end":415},"obj":"UBERON:0001854"},{"id":"T3681","span":{"begin":396,"end":403},"obj":"UBERON:0001853"},{"id":"T3680","span":{"begin":330,"end":346},"obj":"UBERON:0001843"}],"text":"Very few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology."}