PMC:149366 / 18183-20439 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T10073","span":{"begin":1454,"end":1456},"obj":"NNS"},{"id":"T10072","span":{"begin":1450,"end":1453},"obj":"CD"},{"id":"T10071","span":{"begin":1440,"end":1449},"obj":"VBZ"},{"id":"T10070","span":{"begin":1436,"end":1439},"obj":"NNP"},{"id":"T10069","span":{"begin":1435,"end":1457},"obj":"sentence"},{"id":"T10068","span":{"begin":1434,"end":1435},"obj":"."},{"id":"T10067","span":{"begin":1415,"end":1423},"obj":"JJ"},{"id":"T10066","span":{"begin":1424,"end":1434},"obj":"NN"},{"id":"T10065","span":{"begin":1411,"end":1414},"obj":"DT"},{"id":"T10064","span":{"begin":1408,"end":1410},"obj":"IN"},{"id":"T10063","span":{"begin":1401,"end":1407},"obj":"NNS"},{"id":"T10062","span":{"begin":1388,"end":1400},"obj":"JJ"},{"id":"T10061","span":{"begin":1378,"end":1382},"obj":"PRP"},{"id":"T10060","span":{"begin":1383,"end":1387},"obj":"VBP"},{"id":"T10059","span":{"begin":1372,"end":1377},"obj":"WRB"},{"id":"T10058","span":{"begin":1366,"end":1371},"obj":"NNP"},{"id":"T10057","span":{"begin":1363,"end":1365},"obj":"IN"},{"id":"T10056","span":{"begin":1357,"end":1362},"obj":"NN"},{"id":"T10055","span":{"begin":1353,"end":1356},"obj":"DT"},{"id":"T10054","span":{"begin":1350,"end":1352},"obj":"IN"},{"id":"T10053","span":{"begin":1343,"end":1349},"obj":"VBP"},{"id":"T10052","span":{"begin":1336,"end":1342},"obj":"NNS"},{"id":"T10051","span":{"begin":1332,"end":1335},"obj":"CC"},{"id":"T10050","span":{"begin":1330,"end":1331},"obj":"-RRB-"},{"id":"T10049","span":{"begin":1328,"end":1329},"obj":","},{"id":"T10048","span":{"begin":1327,"end":1328},"obj":"NN"},{"id":"T10047","span":{"begin":1329,"end":1330},"obj":"NN"},{"id":"T10046","span":{"begin":1326,"end":1327},"obj":"-LRB-"},{"id":"T10045","span":{"begin":1317,"end":1319},"obj":"POS"},{"id":"T10044","span":{"begin":1320,"end":1325},"obj":"NN"},{"id":"T10043","span":{"begin":1308,"end":1317},"obj":"NNP"},{"id":"T10042","span":{"begin":1305,"end":1307},"obj":"IN"},{"id":"T10041","span":{"begin":1297,"end":1304},"obj":"JJ"},{"id":"T10040","span":{"begin":1277,"end":1284},"obj":"JJ"},{"id":"T10039","span":{"begin":1285,"end":1292},"obj":"NNS"},{"id":"T10038","span":{"begin":1270,"end":1276},"obj":"JJ"},{"id":"T10037","span":{"begin":1268,"end":1270},"obj":","},{"id":"T10036","span":{"begin":1293,"end":1296},"obj":"VBP"},{"id":"T10035","span":{"begin":1261,"end":1268},"obj":"RB"},{"id":"T10034","span":{"begin":1260,"end":1435},"obj":"sentence"},{"id":"T10033","span":{"begin":1259,"end":1260},"obj":"."},{"id":"T10032","span":{"begin":1258,"end":1259},"obj":"-RRB-"},{"id":"T10031","span":{"begin":1256,"end":1257},"obj":","},{"id":"T10030","span":{"begin":1255,"end":1256},"obj":"NN"},{"id":"T10029","span":{"begin":1257,"end":1258},"obj":"NN"},{"id":"T10028","span":{"begin":1254,"end":1255},"obj":"-LRB-"},{"id":"T10027","span":{"begin":1249,"end":1253},"obj":"NN"},{"id":"T10026","span":{"begin":1245,"end":1248},"obj":"DT"},{"id":"T10025","span":{"begin":1242,"end":1244},"obj":"IN"},{"id":"T9978","span":{"begin":1016,"end":1018},"obj":","},{"id":"T9977","span":{"begin":999,"end":1006},"obj":"JJ"},{"id":"T9976","span":{"begin":1007,"end":1016},"obj":"NNS"},{"id":"T9975","span":{"begin":988,"end":998},"obj":"JJ"},{"id":"T9974","span":{"begin":985,"end":987},"obj":"IN"},{"id":"T9973","span":{"begin":977,"end":984},"obj":"NN"},{"id":"T9972","span":{"begin":971,"end":976},"obj":"NN"},{"id":"T9971","span":{"begin":968,"end":970},"obj":"IN"},{"id":"T9970","span":{"begin":950,"end":957},"obj":"JJ"},{"id":"T9969","span":{"begin":958,"end":967},"obj":"NN"},{"id":"T9968","span":{"begin":948,"end":949},"obj":"DT"},{"id":"T9967","span":{"begin":939,"end":944},"obj":"EX"},{"id":"T9966","span":{"begin":931,"end":938},"obj":"NNS"},{"id":"T9965","span":{"begin":928,"end":930},"obj":"NN"},{"id":"T9964","span":{"begin":925,"end":927},"obj":"IN"},{"id":"T9963","span":{"begin":945,"end":947},"obj":"VBZ"},{"id":"T9962","span":{"begin":916,"end":924},"obj":"VBN"},{"id":"T9961","span":{"begin":915,"end":1074},"obj":"sentence"},{"id":"T9960","span":{"begin":914,"end":915},"obj":"."},{"id":"T9959","span":{"begin":903,"end":909},"obj":"JJ"},{"id":"T9958","span":{"begin":898,"end":902},"obj":"JJ"},{"id":"T9957","span":{"begin":892,"end":897},"obj":"NN"},{"id":"T9956","span":{"begin":910,"end":914},"obj":"NNS"},{"id":"T9955","span":{"begin":888,"end":891},"obj":"JJ"},{"id":"T9954","span":{"begin":881,"end":882},"obj":"HYPH"},{"id":"T9953","span":{"begin":882,"end":887},"obj":"JJ"},{"id":"T9952","span":{"begin":880,"end":881},"obj":"JJ"},{"id":"T9951","span":{"begin":877,"end":879},"obj":"IN"},{"id":"T9950","span":{"begin":868,"end":870},"obj":"VBZ"},{"id":"T9949","span":{"begin":858,"end":867},"obj":"NNS"},{"id":"T9948","span":{"begin":850,"end":857},"obj":"JJ"},{"id":"T9947","span":{"begin":847,"end":849},"obj":"IN"},{"id":"T9946","span":{"begin":871,"end":876},"obj":"VBN"},{"id":"T9945","span":{"begin":835,"end":846},"obj":"NN"},{"id":"T9944","span":{"begin":831,"end":834},"obj":"DT"},{"id":"T10024","span":{"begin":1237,"end":1241},"obj":"RB"},{"id":"T10023","span":{"begin":1235,"end":1237},"obj":","},{"id":"T10022","span":{"begin":1228,"end":1235},"obj":"NNS"},{"id":"T10021","span":{"begin":1221,"end":1227},"obj":"JJ"},{"id":"T10020","span":{"begin":1218,"end":1220},"obj":"IN"},{"id":"T10019","span":{"begin":1202,"end":1209},"obj":"VBN"},{"id":"T10018","span":{"begin":1197,"end":1201},"obj":"RB"},{"id":"T10017","span":{"begin":1210,"end":1217},"obj":"NN"},{"id":"T10016","span":{"begin":1195,"end":1196},"obj":"DT"},{"id":"T10015","span":{"begin":1189,"end":1194},"obj":"VBZ"},{"id":"T10014","span":{"begin":1181,"end":1188},"obj":"NN"},{"id":"T10013","span":{"begin":1177,"end":1180},"obj":"DT"},{"id":"T10012","span":{"begin":1176,"end":1260},"obj":"sentence"},{"id":"T10011","span":{"begin":1175,"end":1176},"obj":"."},{"id":"T10010","span":{"begin":1165,"end":1169},"obj":"NN"},{"id":"T10009","span":{"begin":1170,"end":1175},"obj":"NNS"},{"id":"T10008","span":{"begin":1156,"end":1164},"obj":"JJ"},{"id":"T10007","span":{"begin":1152,"end":1155},"obj":"CC"},{"id":"T10006","span":{"begin":1142,"end":1151},"obj":"NNS"},{"id":"T10005","span":{"begin":1136,"end":1141},"obj":"DT"},{"id":"T10004","span":{"begin":1128,"end":1135},"obj":"IN"},{"id":"T10003","span":{"begin":1119,"end":1127},"obj":"NNS"},{"id":"T10002","span":{"begin":1109,"end":1110},"obj":"-RRB-"},{"id":"T10001","span":{"begin":1108,"end":1109},"obj":"NN"},{"id":"T10000","span":{"begin":1107,"end":1108},"obj":"-LRB-"},{"id":"T9999","span":{"begin":1103,"end":1106},"obj":"NN"},{"id":"T9998","span":{"begin":1098,"end":1102},"obj":"IN"},{"id":"T9997","span":{"begin":1111,"end":1118},"obj":"VBP"},{"id":"T9996","span":{"begin":1089,"end":1097},"obj":"NN"},{"id":"T9995","span":{"begin":1075,"end":1088},"obj":"JJ"},{"id":"T9994","span":{"begin":1074,"end":1176},"obj":"sentence"},{"id":"T9993","span":{"begin":1073,"end":1074},"obj":"."},{"id":"T9992","span":{"begin":1072,"end":1073},"obj":"-RRB-"},{"id":"T9991","span":{"begin":1070,"end":1071},"obj":","},{"id":"T9990","span":{"begin":1069,"end":1070},"obj":"NN"},{"id":"T9989","span":{"begin":1071,"end":1072},"obj":"NN"},{"id":"T9988","span":{"begin":1068,"end":1069},"obj":"-LRB-"},{"id":"T9987","span":{"begin":1050,"end":1057},"obj":"JJ"},{"id":"T9986","span":{"begin":1058,"end":1067},"obj":"NNS"},{"id":"T9985","span":{"begin":1046,"end":1049},"obj":"DT"},{"id":"T9984","span":{"begin":1043,"end":1045},"obj":"IN"},{"id":"T9983","span":{"begin":1033,"end":1035},"obj":"VB"},{"id":"T9982","span":{"begin":1029,"end":1032},"obj":"MD"},{"id":"T9981","span":{"begin":1036,"end":1042},"obj":"VBN"},{"id":"T9980","span":{"begin":1022,"end":1028},"obj":"NNS"},{"id":"T9979","span":{"begin":1018,"end":1021},"obj":"CC"},{"id":"T4065","span":{"begin":2255,"end":2256},"obj":"."},{"id":"T4064","span":{"begin":2250,"end":2255},"obj":"NN"},{"id":"T4063","span":{"begin":2244,"end":2249},"obj":"IN"},{"id":"T4062","span":{"begin":2232,"end":2238},"obj":"JJ"},{"id":"T4061","span":{"begin":2239,"end":2243},"obj":"NNS"},{"id":"T4060","span":{"begin":2226,"end":2231},"obj":"NN"},{"id":"T4059","span":{"begin":2223,"end":2225},"obj":"IN"},{"id":"T4058","span":{"begin":2213,"end":2215},"obj":"PRP"},{"id":"T4057","span":{"begin":2216,"end":2222},"obj":"VBZ"},{"id":"T4056","span":{"begin":2210,"end":2212},"obj":"IN"},{"id":"T4055","span":{"begin":2195,"end":2199},"obj":"JJ"},{"id":"T4054","span":{"begin":2186,"end":2194},"obj":"NN"},{"id":"T4053","span":{"begin":2173,"end":2185},"obj":"NN"},{"id":"T4052","span":{"begin":2169,"end":2172},"obj":"CC"},{"id":"T4051","span":{"begin":2200,"end":2209},"obj":"NNS"},{"id":"T4050","span":{"begin":2156,"end":2168},"obj":"NN"},{"id":"T4049","span":{"begin":2151,"end":2155},"obj":"IN"},{"id":"T4048","span":{"begin":2145,"end":2150},"obj":"VBN"},{"id":"T4047","span":{"begin":2140,"end":2144},"obj":"NN"},{"id":"T4046","span":{"begin":2137,"end":2139},"obj":"IN"},{"id":"T4045","span":{"begin":2129,"end":2136},"obj":"NN"},{"id":"T4044","span":{"begin":2125,"end":2128},"obj":"DT"},{"id":"T4043","span":{"begin":2114,"end":2117},"obj":"RB"},{"id":"T4042","span":{"begin":2109,"end":2113},"obj":"VBZ"},{"id":"T4041","span":{"begin":2097,"end":2108},"obj":"NN"},{"id":"T4040","span":{"begin":2094,"end":2096},"obj":"IN"},{"id":"T4039","span":{"begin":2079,"end":2080},"obj":"HYPH"},{"id":"T4038","span":{"begin":2080,"end":2088},"obj":"JJ"},{"id":"T4037","span":{"begin":2073,"end":2079},"obj":"JJ"},{"id":"T4036","span":{"begin":2089,"end":2093},"obj":"NN"},{"id":"T4035","span":{"begin":2069,"end":2072},"obj":"DT"},{"id":"T4034","span":{"begin":2067,"end":2069},"obj":","},{"id":"T4033","span":{"begin":2118,"end":2124},"obj":"VB"},{"id":"T4032","span":{"begin":2056,"end":2067},"obj":"RB"},{"id":"T4031","span":{"begin":2055,"end":2256},"obj":"sentence"},{"id":"T4030","span":{"begin":2054,"end":2055},"obj":"."},{"id":"T4029","span":{"begin":2047,"end":2054},"obj":"NN"},{"id":"T4028","span":{"begin":2043,"end":2046},"obj":"DT"},{"id":"T4027","span":{"begin":2040,"end":2042},"obj":"IN"},{"id":"T4026","span":{"begin":2035,"end":2039},"obj":"NN"},{"id":"T4025","span":{"begin":2031,"end":2034},"obj":"DT"},{"id":"T4024","span":{"begin":2028,"end":2030},"obj":"IN"},{"id":"T4023","span":{"begin":2021,"end":2027},"obj":"NNS"},{"id":"T4022","span":{"begin":2016,"end":2018},"obj":"IN"},{"id":"T4021","span":{"begin":2013,"end":2015},"obj":"RB"},{"id":"T4020","span":{"begin":2007,"end":2012},"obj":"RBS"},{"id":"T4019","span":{"begin":2019,"end":2020},"obj":"CD"},{"id":"T4018","span":{"begin":2004,"end":2006},"obj":"RB"},{"id":"T3800","span":{"begin":388,"end":546},"obj":"sentence"},{"id":"T3799","span":{"begin":387,"end":388},"obj":"."},{"id":"T3798","span":{"begin":386,"end":387},"obj":"-RRB-"},{"id":"T3797","span":{"begin":383,"end":384},"obj":","},{"id":"T3796","span":{"begin":381,"end":383},"obj":"NN"},{"id":"T3795","span":{"begin":376,"end":380},"obj":"NN"},{"id":"T3794","span":{"begin":384,"end":386},"obj":"NN"},{"id":"T3793","span":{"begin":375,"end":376},"obj":"-LRB-"},{"id":"T3792","span":{"begin":358,"end":368},"obj":"JJ"},{"id":"T3791","span":{"begin":354,"end":357},"obj":"DT"},{"id":"T3790","span":{"begin":343,"end":353},"obj":"JJ"},{"id":"T3789","span":{"begin":369,"end":374},"obj":"NN"},{"id":"T3788","span":{"begin":340,"end":342},"obj":"IN"},{"id":"T3787","span":{"begin":338,"end":340},"obj":","},{"id":"T3786","span":{"begin":323,"end":328},"obj":"JJ"},{"id":"T3785","span":{"begin":329,"end":338},"obj":"NNS"},{"id":"T3784","span":{"begin":319,"end":322},"obj":"DT"},{"id":"T3783","span":{"begin":316,"end":318},"obj":"IN"},{"id":"T3782","span":{"begin":300,"end":307},"obj":"JJ"},{"id":"T3781","span":{"begin":289,"end":299},"obj":"JJ"},{"id":"T3780","span":{"begin":285,"end":288},"obj":"JJ"},{"id":"T3779","span":{"begin":280,"end":284},"obj":"RB"},{"id":"T3778","span":{"begin":308,"end":315},"obj":"NNS"},{"id":"T3777","span":{"begin":276,"end":279},"obj":"DT"},{"id":"T3776","span":{"begin":271,"end":275},"obj":"IN"},{"id":"T3775","span":{"begin":261,"end":270},"obj":"VBG"},{"id":"T3774","span":{"begin":254,"end":260},"obj":"NNS"},{"id":"T3773","span":{"begin":251,"end":253},"obj":"IN"},{"id":"T3772","span":{"begin":244,"end":250},"obj":"NN"},{"id":"T3771","span":{"begin":242,"end":243},"obj":"DT"},{"id":"T3770","span":{"begin":236,"end":241},"obj":"RB"},{"id":"T3769","span":{"begin":226,"end":231},"obj":"EX"},{"id":"T3768","span":{"begin":224,"end":226},"obj":","},{"id":"T3767","span":{"begin":232,"end":235},"obj":"VBP"},{"id":"T3766","span":{"begin":217,"end":224},"obj":"RB"},{"id":"T3765","span":{"begin":216,"end":388},"obj":"sentence"},{"id":"T3764","span":{"begin":215,"end":216},"obj":"."},{"id":"T3763","span":{"begin":203,"end":207},"obj":"JJ"},{"id":"T3762","span":{"begin":197,"end":202},"obj":"NN"},{"id":"T3761","span":{"begin":208,"end":215},"obj":"NNS"},{"id":"T3760","span":{"begin":194,"end":196},"obj":"NN"},{"id":"T3759","span":{"begin":191,"end":193},"obj":"IN"},{"id":"T3758","span":{"begin":185,"end":190},"obj":"VBN"},{"id":"T3757","span":{"begin":173,"end":184},"obj":"NN"},{"id":"T3756","span":{"begin":170,"end":172},"obj":"IN"},{"id":"T3755","span":{"begin":162,"end":169},"obj":"NN"},{"id":"T3754","span":{"begin":158,"end":161},"obj":"DT"},{"id":"T3753","span":{"begin":155,"end":157},"obj":"IN"},{"id":"T3752","span":{"begin":137,"end":144},"obj":"JJ"},{"id":"T3751","span":{"begin":145,"end":154},"obj":"NN"},{"id":"T3750","span":{"begin":135,"end":136},"obj":"DT"},{"id":"T3749","span":{"begin":124,"end":134},"obj":"VBG"},{"id":"T3748","span":{"begin":119,"end":123},"obj":"RB"},{"id":"T3747","span":{"begin":117,"end":119},"obj":","},{"id":"T3746","span":{"begin":116,"end":117},"obj":"-RRB-"},{"id":"T3745","span":{"begin":109,"end":113},"obj":"NNP"},{"id":"T3744","span":{"begin":114,"end":116},"obj":"NN"},{"id":"T3743","span":{"begin":108,"end":109},"obj":"-LRB-"},{"id":"T3742","span":{"begin":80,"end":90},"obj":"JJ"},{"id":"T3741","span":{"begin":91,"end":100},"obj":"NNS"},{"id":"T3740","span":{"begin":76,"end":79},"obj":"DT"},{"id":"T3739","span":{"begin":73,"end":75},"obj":"IN"},{"id":"T3738","span":{"begin":71,"end":72},"obj":"-RRB-"},{"id":"T3737","span":{"begin":63,"end":71},"obj":"JJ"},{"id":"T3736","span":{"begin":59,"end":62},"obj":"CC"},{"id":"T3735","span":{"begin":50,"end":58},"obj":"JJ"},{"id":"T3734","span":{"begin":45,"end":49},"obj":"CC"},{"id":"T3733","span":{"begin":44,"end":45},"obj":"-LRB-"},{"id":"T3732","span":{"begin":101,"end":107},"obj":"VBP"},{"id":"T3731","span":{"begin":37,"end":43},"obj":"NNS"},{"id":"T3730","span":{"begin":33,"end":36},"obj":"JJ"},{"id":"T3729","span":{"begin":28,"end":32},"obj":"JJ"},{"id":"T3728","span":{"begin":27,"end":216},"obj":"sentence"},{"id":"T3727","span":{"begin":15,"end":19},"obj":"JJ"},{"id":"T3726","span":{"begin":9,"end":14},"obj":"NN"},{"id":"T3725","span":{"begin":20,"end":27},"obj":"NNS"},{"id":"T3724","span":{"begin":2,"end":8},"obj":"NNS"},{"id":"T3723","span":{"begin":0,"end":1},"obj":"CD"},{"id":"T3990","span":{"begin":1862,"end":1864},"obj":"NN"},{"id":"T3989","span":{"begin":1857,"end":1861},"obj":"NN"},{"id":"T3988","span":{"begin":1865,"end":1867},"obj":"NN"},{"id":"T3987","span":{"begin":1856,"end":1857},"obj":"-LRB-"},{"id":"T3986","span":{"begin":1851,"end":1855},"obj":"NN"},{"id":"T3985","span":{"begin":1847,"end":1850},"obj":"DT"},{"id":"T3984","span":{"begin":1844,"end":1846},"obj":"IN"},{"id":"T3983","span":{"begin":1836,"end":1843},"obj":"JJ"},{"id":"T3982","span":{"begin":1821,"end":1827},"obj":"JJ"},{"id":"T3981","span":{"begin":1828,"end":1835},"obj":"NNS"},{"id":"T3980","span":{"begin":1812,"end":1820},"obj":"JJ"},{"id":"T3979","span":{"begin":1806,"end":1811},"obj":"RB"},{"id":"T3978","span":{"begin":1796,"end":1801},"obj":"EX"},{"id":"T3977","span":{"begin":1785,"end":1795},"obj":"NN"},{"id":"T3976","span":{"begin":1782,"end":1784},"obj":"IN"},{"id":"T3975","span":{"begin":1771,"end":1775},"obj":"JJ"},{"id":"T3974","span":{"begin":1776,"end":1781},"obj":"NN"},{"id":"T3973","span":{"begin":1766,"end":1770},"obj":"DT"},{"id":"T3972","span":{"begin":1802,"end":1805},"obj":"VBP"},{"id":"T3971","span":{"begin":1763,"end":1765},"obj":"IN"},{"id":"T3970","span":{"begin":1758,"end":1762},"obj":"RB"},{"id":"T3969","span":{"begin":1757,"end":1869},"obj":"sentence"},{"id":"T3968","span":{"begin":1756,"end":1757},"obj":"."},{"id":"T3967","span":{"begin":1755,"end":1756},"obj":"-RRB-"},{"id":"T3966","span":{"begin":1753,"end":1755},"obj":"CD"},{"id":"T3965","span":{"begin":1748,"end":1752},"obj":"NN"},{"id":"T3964","span":{"begin":1747,"end":1748},"obj":"-LRB-"},{"id":"T3963","span":{"begin":1736,"end":1740},"obj":"NN"},{"id":"T3962","span":{"begin":1730,"end":1735},"obj":"JJ"},{"id":"T3961","span":{"begin":1741,"end":1746},"obj":"NNS"},{"id":"T3960","span":{"begin":1726,"end":1729},"obj":"DT"},{"id":"T3959","span":{"begin":1723,"end":1725},"obj":"IN"},{"id":"T3958","span":{"begin":1718,"end":1722},"obj":"NN"},{"id":"T3957","span":{"begin":1714,"end":1717},"obj":"DT"},{"id":"T3956","span":{"begin":1709,"end":1713},"obj":"IN"},{"id":"T3955","span":{"begin":1695,"end":1701},"obj":"JJ"},{"id":"T3954","span":{"begin":1689,"end":1694},"obj":"JJ"},{"id":"T3953","span":{"begin":1702,"end":1708},"obj":"NN"},{"id":"T3952","span":{"begin":1685,"end":1688},"obj":"DT"},{"id":"T3951","span":{"begin":1678,"end":1684},"obj":"IN"},{"id":"T3950","span":{"begin":1670,"end":1677},"obj":"VBZ"},{"id":"T3949","span":{"begin":1653,"end":1663},"obj":"JJ"},{"id":"T3851","span":{"begin":658,"end":666},"obj":"JJ"},{"id":"T3850","span":{"begin":667,"end":673},"obj":"NNS"},{"id":"T3849","span":{"begin":654,"end":657},"obj":"DT"},{"id":"T3848","span":{"begin":651,"end":653},"obj":"IN"},{"id":"T3847","span":{"begin":641,"end":650},"obj":"VBN"},{"id":"T3846","span":{"begin":630,"end":640},"obj":"RB"},{"id":"T3845","span":{"begin":624,"end":629},"obj":"NNS"},{"id":"T3844","span":{"begin":621,"end":623},"obj":"IN"},{"id":"T3843","span":{"begin":617,"end":620},"obj":"NN"},{"id":"T3842","span":{"begin":612,"end":616},"obj":"IN"},{"id":"T3841","span":{"begin":589,"end":602},"obj":"JJ"},{"id":"T3840","span":{"begin":603,"end":611},"obj":"NN"},{"id":"T3839","span":{"begin":584,"end":588},"obj":"DT"},{"id":"T3838","span":{"begin":575,"end":580},"obj":"EX"},{"id":"T3837","span":{"begin":573,"end":575},"obj":","},{"id":"T3836","span":{"begin":569,"end":573},"obj":"NNS"},{"id":"T3835","span":{"begin":561,"end":568},"obj":"NN"},{"id":"T3834","span":{"begin":558,"end":560},"obj":"IN"},{"id":"T3833","span":{"begin":581,"end":583},"obj":"VBZ"},{"id":"T3832","span":{"begin":547,"end":557},"obj":"JJ"},{"id":"T3831","span":{"begin":546,"end":717},"obj":"sentence"},{"id":"T3830","span":{"begin":545,"end":546},"obj":"."},{"id":"T3829","span":{"begin":544,"end":545},"obj":"-RRB-"},{"id":"T3828","span":{"begin":535,"end":538},"obj":"RB"},{"id":"T3827","span":{"begin":539,"end":544},"obj":"VBN"},{"id":"T3826","span":{"begin":530,"end":534},"obj":"NNS"},{"id":"T3825","span":{"begin":526,"end":529},"obj":"CC"},{"id":"T3824","span":{"begin":518,"end":522},"obj":"NN"},{"id":"T3823","span":{"begin":523,"end":525},"obj":"NN"},{"id":"T3822","span":{"begin":517,"end":518},"obj":"-LRB-"},{"id":"T3821","span":{"begin":508,"end":516},"obj":"JJ"},{"id":"T3820","span":{"begin":501,"end":507},"obj":"RB"},{"id":"T3819","span":{"begin":485,"end":494},"obj":"NNS"},{"id":"T3818","span":{"begin":479,"end":484},"obj":"DT"},{"id":"T3817","span":{"begin":476,"end":478},"obj":"IN"},{"id":"T3816","span":{"begin":466,"end":475},"obj":"NNS"},{"id":"T3815","span":{"begin":463,"end":465},"obj":"IN"},{"id":"T3814","span":{"begin":495,"end":500},"obj":"VBG"},{"id":"T3813","span":{"begin":453,"end":462},"obj":"NN"},{"id":"T3812","span":{"begin":449,"end":452},"obj":"DT"},{"id":"T3811","span":{"begin":444,"end":448},"obj":"IN"},{"id":"T3810","span":{"begin":436,"end":443},"obj":"NN"},{"id":"T3809","span":{"begin":432,"end":435},"obj":"CC"},{"id":"T3808","span":{"begin":424,"end":431},"obj":"NN"},{"id":"T3807","span":{"begin":420,"end":423},"obj":"DT"},{"id":"T3806","span":{"begin":417,"end":419},"obj":"IN"},{"id":"T3805","span":{"begin":410,"end":416},"obj":"VBP"},{"id":"T3804","span":{"begin":399,"end":402},"obj":"JJ"},{"id":"T3803","span":{"begin":394,"end":398},"obj":"RB"},{"id":"T3802","span":{"begin":403,"end":409},"obj":"NNS"},{"id":"T3801","span":{"begin":389,"end":393},"obj":"RB"},{"id":"T4017","span":{"begin":1997,"end":2003},"obj":"NNS"},{"id":"T4016","span":{"begin":1992,"end":1996},"obj":"DT"},{"id":"T4015","span":{"begin":1983,"end":1991},"obj":"VB"},{"id":"T4014","span":{"begin":1980,"end":1982},"obj":"TO"},{"id":"T4013","span":{"begin":1976,"end":1979},"obj":"CC"},{"id":"T4012","span":{"begin":1966,"end":1975},"obj":"NN"},{"id":"T4011","span":{"begin":1960,"end":1965},"obj":"NN"},{"id":"T4010","span":{"begin":1953,"end":1959},"obj":"VB"},{"id":"T4009","span":{"begin":1950,"end":1952},"obj":"TO"},{"id":"T4008","span":{"begin":1940,"end":1949},"obj":"JJ"},{"id":"T4007","span":{"begin":1936,"end":1939},"obj":"RB"},{"id":"T4006","span":{"begin":1921,"end":1925},"obj":"NN"},{"id":"T4005","span":{"begin":1926,"end":1931},"obj":"NNS"},{"id":"T4004","span":{"begin":1914,"end":1920},"obj":"JJ"},{"id":"T4003","span":{"begin":1932,"end":1935},"obj":"VBP"},{"id":"T4002","span":{"begin":1909,"end":1913},"obj":"IN"},{"id":"T4001","span":{"begin":1888,"end":1895},"obj":"VBG"},{"id":"T4000","span":{"begin":1896,"end":1900},"obj":"NNS"},{"id":"T3999","span":{"begin":1882,"end":1887},"obj":"DT"},{"id":"T3998","span":{"begin":1880,"end":1882},"obj":","},{"id":"T3997","span":{"begin":1873,"end":1880},"obj":"NN"},{"id":"T3996","span":{"begin":1901,"end":1908},"obj":"VBP"},{"id":"T3995","span":{"begin":1870,"end":1872},"obj":"IN"},{"id":"T3994","span":{"begin":1869,"end":2055},"obj":"sentence"},{"id":"T3993","span":{"begin":1868,"end":1869},"obj":"."},{"id":"T3992","span":{"begin":1867,"end":1868},"obj":"-RRB-"},{"id":"T3991","span":{"begin":1864,"end":1865},"obj":","},{"id":"T10074","span":{"begin":1456,"end":1457},"obj":"."},{"id":"T3897","span":{"begin":1473,"end":1474},"obj":"VBZ"},{"id":"T3896","span":{"begin":1472,"end":1473},"obj":"NN"},{"id":"T3895","span":{"begin":1472,"end":1477},"obj":"sentence"},{"id":"T3894","span":{"begin":1471,"end":1472},"obj":"JJ"},{"id":"T3893","span":{"begin":1470,"end":1472},"obj":"sentence"},{"id":"T3892","span":{"begin":1469,"end":1470},"obj":","},{"id":"T3891","span":{"begin":1468,"end":1469},"obj":"MD"},{"id":"T3890","span":{"begin":1467,"end":1468},"obj":"NNS"},{"id":"T3889","span":{"begin":1465,"end":1467},"obj":"NNS"},{"id":"T3888","span":{"begin":1464,"end":1465},"obj":"NN"},{"id":"T3887","span":{"begin":1463,"end":1464},"obj":"VBN"},{"id":"T3886","span":{"begin":1463,"end":1470},"obj":"sentence"},{"id":"T3885","span":{"begin":1462,"end":1463},"obj":"NN"},{"id":"T3884","span":{"begin":1458,"end":1461},"obj":"DT"},{"id":"T3883","span":{"begin":1458,"end":1463},"obj":"sentence"},{"id":"T3882","span":{"begin":820,"end":821},"obj":"sentence"},{"id":"T3881","span":{"begin":819,"end":820},"obj":"."},{"id":"T3880","span":{"begin":809,"end":819},"obj":"NN"},{"id":"T3879","span":{"begin":803,"end":808},"obj":"PRP$"},{"id":"T3878","span":{"begin":800,"end":802},"obj":"IN"},{"id":"T3877","span":{"begin":794,"end":799},"obj":"VBN"},{"id":"T3876","span":{"begin":783,"end":787},"obj":"NN"},{"id":"T3875","span":{"begin":788,"end":793},"obj":"NNS"},{"id":"T3874","span":{"begin":774,"end":782},"obj":"JJ"},{"id":"T3873","span":{"begin":771,"end":773},"obj":"IN"},{"id":"T3872","span":{"begin":752,"end":759},"obj":"RB"},{"id":"T3871","span":{"begin":749,"end":751},"obj":"VB"},{"id":"T3870","span":{"begin":745,"end":748},"obj":"RB"},{"id":"T3869","span":{"begin":739,"end":744},"obj":"MD"},{"id":"T3868","span":{"begin":733,"end":738},"obj":"NNS"},{"id":"T3867","span":{"begin":727,"end":732},"obj":"DT"},{"id":"T3866","span":{"begin":725,"end":727},"obj":","},{"id":"T3865","span":{"begin":760,"end":770},"obj":"VBN"},{"id":"T3864","span":{"begin":718,"end":725},"obj":"RB"},{"id":"T3863","span":{"begin":717,"end":820},"obj":"sentence"},{"id":"T3862","span":{"begin":716,"end":717},"obj":"."},{"id":"T3861","span":{"begin":715,"end":716},"obj":"-RRB-"},{"id":"T3860","span":{"begin":708,"end":712},"obj":"NN"},{"id":"T3859","span":{"begin":713,"end":715},"obj":"NN"},{"id":"T3858","span":{"begin":707,"end":708},"obj":"-LRB-"},{"id":"T3857","span":{"begin":692,"end":698},"obj":"JJ"},{"id":"T3856","span":{"begin":687,"end":691},"obj":"JJ"},{"id":"T3855","span":{"begin":681,"end":686},"obj":"NN"},{"id":"T3854","span":{"begin":699,"end":706},"obj":"NN"},{"id":"T3853","span":{"begin":677,"end":680},"obj":"DT"},{"id":"T3852","span":{"begin":674,"end":676},"obj":"IN"},{"id":"T3948","span":{"begin":1650,"end":1652},"obj":"DT"},{"id":"T3947","span":{"begin":1664,"end":1669},"obj":"NN"},{"id":"T3946","span":{"begin":1645,"end":1649},"obj":"RB"},{"id":"T3945","span":{"begin":1644,"end":1757},"obj":"sentence"},{"id":"T3944","span":{"begin":1643,"end":1644},"obj":"."},{"id":"T3943","span":{"begin":1642,"end":1643},"obj":"-RRB-"},{"id":"T3942","span":{"begin":1640,"end":1642},"obj":"CD"},{"id":"T3941","span":{"begin":1635,"end":1639},"obj":"NN"},{"id":"T3940","span":{"begin":1634,"end":1635},"obj":"-LRB-"},{"id":"T3939","span":{"begin":1623,"end":1633},"obj":"JJ"},{"id":"T3938","span":{"begin":1605,"end":1610},"obj":"NN"},{"id":"T3937","span":{"begin":1598,"end":1604},"obj":"JJ"},{"id":"T3936","span":{"begin":1611,"end":1618},"obj":"NNS"},{"id":"T3935","span":{"begin":1594,"end":1597},"obj":"DT"},{"id":"T3934","span":{"begin":1591,"end":1593},"obj":"IN"},{"id":"T3933","span":{"begin":1619,"end":1622},"obj":"VBP"},{"id":"T3932","span":{"begin":1586,"end":1590},"obj":"DT"},{"id":"T3931","span":{"begin":1585,"end":1644},"obj":"sentence"},{"id":"T3930","span":{"begin":1584,"end":1585},"obj":"."},{"id":"T3929","span":{"begin":1583,"end":1584},"obj":"-RRB-"},{"id":"T3928","span":{"begin":1576,"end":1580},"obj":"NN"},{"id":"T3927","span":{"begin":1581,"end":1583},"obj":"NN"},{"id":"T3926","span":{"begin":1575,"end":1576},"obj":"-LRB-"},{"id":"T3925","span":{"begin":1561,"end":1567},"obj":"JJ"},{"id":"T3924","span":{"begin":1555,"end":1560},"obj":"JJ"},{"id":"T3923","span":{"begin":1543,"end":1554},"obj":"JJ"},{"id":"T3922","span":{"begin":1568,"end":1574},"obj":"NN"},{"id":"T3921","span":{"begin":1540,"end":1542},"obj":"DT"},{"id":"T3920","span":{"begin":1535,"end":1539},"obj":"VBP"},{"id":"T3919","span":{"begin":1529,"end":1534},"obj":"WDT"},{"id":"T3918","span":{"begin":1527,"end":1529},"obj":","},{"id":"T3917","span":{"begin":1512,"end":1520},"obj":"JJ"},{"id":"T3916","span":{"begin":1521,"end":1527},"obj":"NNS"},{"id":"T3915","span":{"begin":1507,"end":1511},"obj":"JJ"},{"id":"T3914","span":{"begin":1496,"end":1498},"obj":","},{"id":"T3913","span":{"begin":1488,"end":1491},"obj":"DT"},{"id":"T3912","span":{"begin":1492,"end":1496},"obj":"NN"},{"id":"T3911","span":{"begin":1486,"end":1487},"obj":"RB"},{"id":"T3910","span":{"begin":1498,"end":1506},"obj":"VBZ"},{"id":"T3909","span":{"begin":1485,"end":1486},"obj":"NN"},{"id":"T3908","span":{"begin":1485,"end":1585},"obj":"sentence"},{"id":"T3907","span":{"begin":1483,"end":1485},"obj":"VBZ"},{"id":"T3906","span":{"begin":1483,"end":1485},"obj":"sentence"},{"id":"T3905","span":{"begin":1482,"end":1483},"obj":"DT"},{"id":"T3904","span":{"begin":1480,"end":1482},"obj":"JJ"},{"id":"T3903","span":{"begin":1479,"end":1480},"obj":"VBP"},{"id":"T3902","span":{"begin":1478,"end":1479},"obj":"JJ"},{"id":"T3901","span":{"begin":1477,"end":1478},"obj":"RB"},{"id":"T3900","span":{"begin":1477,"end":1483},"obj":"sentence"},{"id":"T3899","span":{"begin":1476,"end":1477},"obj":"NN"},{"id":"T3898","span":{"begin":1474,"end":1475},"obj":"NN"}],"relations":[{"id":"R2321","pred":"nummod","subj":"T3723","obj":"T3724"},{"id":"R2322","pred":"nmod","subj":"T3724","obj":"T3725"},{"id":"R2323","pred":"npadvmod","subj":"T3726","obj":"T3727"},{"id":"R2324","pred":"amod","subj":"T3727","obj":"T3725"},{"id":"R2325","pred":"amod","subj":"T3729","obj":"T3730"},{"id":"R2326","pred":"amod","subj":"T3730","obj":"T3731"},{"id":"R2327","pred":"nsubj","subj":"T3731","obj":"T3732"},{"id":"R2328","pred":"punct","subj":"T3733","obj":"T3731"},{"id":"R2329","pred":"preconj","subj":"T3734","obj":"T3735"},{"id":"R2330","pred":"amod","subj":"T3735","obj":"T3731"},{"id":"R2331","pred":"cc","subj":"T3736","obj":"T3735"},{"id":"R2332","pred":"conj","subj":"T3737","obj":"T3735"},{"id":"R2333","pred":"punct","subj":"T3738","obj":"T3731"},{"id":"R2334","pred":"prep","subj":"T3739","obj":"T3731"},{"id":"R2335","pred":"det","subj":"T3740","obj":"T3741"},{"id":"R2336","pred":"pobj","subj":"T3741","obj":"T3739"},{"id":"R2337","pred":"amod","subj":"T3742","obj":"T3741"},{"id":"R2338","pred":"punct","subj":"T3743","obj":"T3744"},{"id":"R2339","pred":"parataxis","subj":"T3744","obj":"T3732"},{"id":"R2340","pred":"compound","subj":"T3745","obj":"T3744"},{"id":"R2341","pred":"punct","subj":"T3746","obj":"T3744"},{"id":"R2342","pred":"punct","subj":"T3747","obj":"T3732"},{"id":"R2343","pred":"advmod","subj":"T3748","obj":"T3749"},{"id":"R2344","pred":"advcl","subj":"T3749","obj":"T3732"},{"id":"R2345","pred":"det","subj":"T3750","obj":"T3751"},{"id":"R2346","pred":"dobj","subj":"T3751","obj":"T3749"},{"id":"R2347","pred":"amod","subj":"T3752","obj":"T3751"},{"id":"R2348","pred":"prep","subj":"T3753","obj":"T3751"},{"id":"R2349","pred":"det","subj":"T3754","obj":"T3755"},{"id":"R2350","pred":"pobj","subj":"T3755","obj":"T3753"},{"id":"R2351","pred":"prep","subj":"T3756","obj":"T3755"},{"id":"R2352","pred":"pobj","subj":"T3757","obj":"T3756"},{"id":"R2353","pred":"acl","subj":"T3758","obj":"T3755"},{"id":"R2354","pred":"prep","subj":"T3759","obj":"T3758"},{"id":"R2355","pred":"nmod","subj":"T3760","obj":"T3761"},{"id":"R2356","pred":"pobj","subj":"T3761","obj":"T3759"},{"id":"R2357","pred":"nmod","subj":"T3762","obj":"T3761"},{"id":"R2358","pred":"amod","subj":"T3763","obj":"T3761"},{"id":"R2359","pred":"punct","subj":"T3764","obj":"T3732"},{"id":"R2360","pred":"advmod","subj":"T3766","obj":"T3767"},{"id":"R2361","pred":"punct","subj":"T3768","obj":"T3767"},{"id":"R2362","pred":"expl","subj":"T3769","obj":"T3767"},{"id":"R2363","pred":"advmod","subj":"T3770","obj":"T3767"},{"id":"R2364","pred":"det","subj":"T3771","obj":"T3772"},{"id":"R2365","pred":"attr","subj":"T3772","obj":"T3767"},{"id":"R2366","pred":"prep","subj":"T3773","obj":"T3772"},{"id":"R2367","pred":"pobj","subj":"T3774","obj":"T3773"},{"id":"R2368","pred":"acl","subj":"T3775","obj":"T3774"},{"id":"R2369","pred":"prep","subj":"T3776","obj":"T3775"},{"id":"R2370","pred":"det","subj":"T3777","obj":"T3778"},{"id":"R2371","pred":"pobj","subj":"T3778","obj":"T3776"},{"id":"R2372","pred":"advmod","subj":"T3779","obj":"T3780"},{"id":"R2373","pred":"amod","subj":"T3780","obj":"T3778"},{"id":"R2374","pred":"amod","subj":"T3781","obj":"T3778"},{"id":"R2375","pred":"amod","subj":"T3782","obj":"T3778"},{"id":"R2376","pred":"prep","subj":"T3783","obj":"T3775"},{"id":"R2377","pred":"det","subj":"T3784","obj":"T3785"},{"id":"R2378","pred":"pobj","subj":"T3785","obj":"T3783"},{"id":"R2379","pred":"amod","subj":"T3786","obj":"T3785"},{"id":"R2380","pred":"punct","subj":"T3787","obj":"T3785"},{"id":"R2381","pred":"prep","subj":"T3788","obj":"T3789"},{"id":"R2382","pred":"appos","subj":"T3789","obj":"T3785"},{"id":"R2383","pred":"amod","subj":"T3790","obj":"T3788"},{"id":"R2384","pred":"det","subj":"T3791","obj":"T3789"},{"id":"R2385","pred":"amod","subj":"T3792","obj":"T3789"},{"id":"R2386","pred":"punct","subj":"T3793","obj":"T3794"},{"id":"R2387","pred":"parataxis","subj":"T3794","obj":"T3767"},{"id":"R2388","pred":"nmod","subj":"T3795","obj":"T3794"},{"id":"R2389","pred":"nmod","subj":"T3796","obj":"T3794"},{"id":"R2390","pred":"punct","subj":"T3797","obj":"T3794"},{"id":"R2391","pred":"punct","subj":"T3798","obj":"T3794"},{"id":"R2392","pred":"punct","subj":"T3799","obj":"T3767"},{"id":"R2393","pred":"advmod","subj":"T3801","obj":"T3802"},{"id":"R2394","pred":"nsubj","subj":"T3802","obj":"T3805"},{"id":"R2395","pred":"advmod","subj":"T3803","obj":"T3804"},{"id":"R2396","pred":"amod","subj":"T3804","obj":"T3802"},{"id":"R2397","pred":"prep","subj":"T3806","obj":"T3805"},{"id":"R2398","pred":"det","subj":"T3807","obj":"T3808"},{"id":"R2399","pred":"pobj","subj":"T3808","obj":"T3806"},{"id":"R2400","pred":"cc","subj":"T3809","obj":"T3808"},{"id":"R2401","pred":"conj","subj":"T3810","obj":"T3808"},{"id":"R2402","pred":"prep","subj":"T3811","obj":"T3805"},{"id":"R2403","pred":"det","subj":"T3812","obj":"T3813"},{"id":"R2404","pred":"nsubj","subj":"T3813","obj":"T3814"},{"id":"R2405","pred":"pcomp","subj":"T3814","obj":"T3811"},{"id":"R2406","pred":"prep","subj":"T3815","obj":"T3813"},{"id":"R2407","pred":"pobj","subj":"T3816","obj":"T3815"},{"id":"R2408","pred":"prep","subj":"T3817","obj":"T3813"},{"id":"R2409","pred":"det","subj":"T3818","obj":"T3819"},{"id":"R2410","pred":"pobj","subj":"T3819","obj":"T3817"},{"id":"R2411","pred":"advmod","subj":"T3820","obj":"T3821"},{"id":"R2412","pred":"acomp","subj":"T3821","obj":"T3814"},{"id":"R2413","pred":"punct","subj":"T3822","obj":"T3823"},{"id":"R2414","pred":"parataxis","subj":"T3823","obj":"T3805"},{"id":"R2415","pred":"compound","subj":"T3824","obj":"T3823"},{"id":"R2416","pred":"cc","subj":"T3825","obj":"T3823"},{"id":"R2417","pred":"nsubj","subj":"T3826","obj":"T3827"},{"id":"R2418","pred":"conj","subj":"T3827","obj":"T3823"},{"id":"R2419","pred":"neg","subj":"T3828","obj":"T3827"},{"id":"R2420","pred":"punct","subj":"T3829","obj":"T3827"},{"id":"R2421","pred":"punct","subj":"T3830","obj":"T3805"},{"id":"R2422","pred":"advcl","subj":"T3832","obj":"T3833"},{"id":"R2423","pred":"prep","subj":"T3834","obj":"T3832"},{"id":"R2424","pred":"compound","subj":"T3835","obj":"T3836"},{"id":"R2425","pred":"pobj","subj":"T3836","obj":"T3834"},{"id":"R2426","pred":"punct","subj":"T3837","obj":"T3833"},{"id":"R2427","pred":"expl","subj":"T3838","obj":"T3833"},{"id":"R2428","pred":"det","subj":"T3839","obj":"T3840"},{"id":"R2429","pred":"attr","subj":"T3840","obj":"T3833"},{"id":"R2430","pred":"amod","subj":"T3841","obj":"T3840"},{"id":"R2431","pred":"prep","subj":"T3842","obj":"T3840"},{"id":"R2432","pred":"pobj","subj":"T3843","obj":"T3842"},{"id":"R2433","pred":"prep","subj":"T3844","obj":"T3840"},{"id":"R2434","pred":"pobj","subj":"T3845","obj":"T3844"},{"id":"R2435","pred":"advmod","subj":"T3846","obj":"T3847"},{"id":"R2436","pred":"acl","subj":"T3847","obj":"T3845"},{"id":"R2437","pred":"agent","subj":"T3848","obj":"T3847"},{"id":"R2438","pred":"det","subj":"T3849","obj":"T3850"},{"id":"R2439","pred":"pobj","subj":"T3850","obj":"T3848"},{"id":"R2440","pred":"amod","subj":"T3851","obj":"T3850"},{"id":"R2441","pred":"prep","subj":"T3852","obj":"T3847"},{"id":"R2442","pred":"det","subj":"T3853","obj":"T3854"},{"id":"R2483","pred":"dobj","subj":"T3922","obj":"T3920"},{"id":"R2484","pred":"amod","subj":"T3923","obj":"T3922"},{"id":"R2485","pred":"amod","subj":"T3924","obj":"T3925"},{"id":"R2486","pred":"nmod","subj":"T3925","obj":"T3922"},{"id":"R2487","pred":"punct","subj":"T3926","obj":"T3927"},{"id":"R2488","pred":"parataxis","subj":"T3927","obj":"T3910"},{"id":"R2489","pred":"compound","subj":"T3928","obj":"T3927"},{"id":"R2490","pred":"punct","subj":"T3929","obj":"T3927"},{"id":"R2491","pred":"punct","subj":"T3930","obj":"T3910"},{"id":"R2492","pred":"nsubj","subj":"T3932","obj":"T3933"},{"id":"R2493","pred":"prep","subj":"T3934","obj":"T3932"},{"id":"R2494","pred":"det","subj":"T3935","obj":"T3936"},{"id":"R2495","pred":"pobj","subj":"T3936","obj":"T3934"},{"id":"R2496","pred":"amod","subj":"T3937","obj":"T3938"},{"id":"R2497","pred":"compound","subj":"T3938","obj":"T3936"},{"id":"R2498","pred":"acomp","subj":"T3939","obj":"T3933"},{"id":"R2499","pred":"punct","subj":"T3940","obj":"T3941"},{"id":"R2500","pred":"parataxis","subj":"T3941","obj":"T3933"},{"id":"R2501","pred":"nummod","subj":"T3942","obj":"T3941"},{"id":"R2502","pred":"punct","subj":"T3943","obj":"T3941"},{"id":"R2503","pred":"punct","subj":"T3944","obj":"T3933"},{"id":"R2504","pred":"advmod","subj":"T3946","obj":"T3947"},{"id":"R2505","pred":"nsubj","subj":"T3947","obj":"T3950"},{"id":"R2506","pred":"det","subj":"T3948","obj":"T3947"},{"id":"R2507","pred":"amod","subj":"T3949","obj":"T3947"},{"id":"R2508","pred":"prep","subj":"T3951","obj":"T3950"},{"id":"R2509","pred":"det","subj":"T3952","obj":"T3953"},{"id":"R2510","pred":"pobj","subj":"T3953","obj":"T3951"},{"id":"R2511","pred":"amod","subj":"T3954","obj":"T3955"},{"id":"R2512","pred":"nmod","subj":"T3955","obj":"T3953"},{"id":"R2513","pred":"prep","subj":"T3956","obj":"T3950"},{"id":"R2514","pred":"det","subj":"T3957","obj":"T3958"},{"id":"R2515","pred":"pobj","subj":"T3958","obj":"T3956"},{"id":"R2516","pred":"prep","subj":"T3959","obj":"T3958"},{"id":"R2517","pred":"det","subj":"T3960","obj":"T3961"},{"id":"R2518","pred":"pobj","subj":"T3961","obj":"T3959"},{"id":"R2519","pred":"amod","subj":"T3962","obj":"T3961"},{"id":"R2520","pred":"compound","subj":"T3963","obj":"T3961"},{"id":"R2521","pred":"punct","subj":"T3964","obj":"T3965"},{"id":"R2522","pred":"parataxis","subj":"T3965","obj":"T3950"},{"id":"R2523","pred":"nummod","subj":"T3966","obj":"T3965"},{"id":"R2524","pred":"punct","subj":"T3967","obj":"T3965"},{"id":"R2525","pred":"punct","subj":"T3968","obj":"T3950"},{"id":"R2526","pred":"advmod","subj":"T3970","obj":"T3971"},{"id":"R2527","pred":"prep","subj":"T3971","obj":"T3972"},{"id":"R2528","pred":"det","subj":"T3973","obj":"T3974"},{"id":"R2529","pred":"pobj","subj":"T3974","obj":"T3971"},{"id":"R2530","pred":"amod","subj":"T3975","obj":"T3974"},{"id":"R2531","pred":"prep","subj":"T3976","obj":"T3974"},{"id":"R2532","pred":"pobj","subj":"T3977","obj":"T3976"},{"id":"R2533","pred":"expl","subj":"T3978","obj":"T3972"},{"id":"R2534","pred":"advmod","subj":"T3979","obj":"T3972"},{"id":"R2535","pred":"amod","subj":"T3980","obj":"T3981"},{"id":"R2536","pred":"attr","subj":"T3981","obj":"T3972"},{"id":"R2537","pred":"amod","subj":"T3982","obj":"T3981"},{"id":"R2538","pred":"relcl","subj":"T3983","obj":"T3981"},{"id":"R2539","pred":"prep","subj":"T3984","obj":"T3983"},{"id":"R2540","pred":"det","subj":"T3985","obj":"T3986"},{"id":"R2541","pred":"pobj","subj":"T3986","obj":"T3984"},{"id":"R2542","pred":"punct","subj":"T3987","obj":"T3988"},{"id":"R2543","pred":"parataxis","subj":"T3988","obj":"T3972"},{"id":"R2544","pred":"nmod","subj":"T3989","obj":"T3988"},{"id":"R2545","pred":"nmod","subj":"T3990","obj":"T3988"},{"id":"R2546","pred":"punct","subj":"T3991","obj":"T3988"},{"id":"R2547","pred":"punct","subj":"T3992","obj":"T3988"},{"id":"R2548","pred":"punct","subj":"T3993","obj":"T3972"},{"id":"R2549","pred":"prep","subj":"T3995","obj":"T3996"},{"id":"R2550","pred":"pobj","subj":"T3997","obj":"T3995"},{"id":"R2551","pred":"punct","subj":"T3998","obj":"T3996"},{"id":"R2552","pred":"det","subj":"T3999","obj":"T4000"},{"id":"R2553","pred":"nsubj","subj":"T4000","obj":"T3996"},{"id":"R2554","pred":"amod","subj":"T4001","obj":"T4000"},{"id":"R2555","pred":"mark","subj":"T4002","obj":"T4003"},{"id":"R2556","pred":"ccomp","subj":"T4003","obj":"T3996"},{"id":"R2557","pred":"amod","subj":"T4004","obj":"T4005"},{"id":"R2558","pred":"nsubj","subj":"T4005","obj":"T4003"},{"id":"R2559","pred":"compound","subj":"T4006","obj":"T4005"},{"id":"R2560","pred":"neg","subj":"T4007","obj":"T4003"},{"id":"R2561","pred":"acomp","subj":"T4008","obj":"T4003"},{"id":"R2562","pred":"aux","subj":"T4009","obj":"T4010"},{"id":"R2563","pred":"xcomp","subj":"T4010","obj":"T4008"},{"id":"R2564","pred":"compound","subj":"T4011","obj":"T4012"},{"id":"R2565","pred":"dobj","subj":"T4012","obj":"T4010"},{"id":"R2566","pred":"cc","subj":"T4013","obj":"T4010"},{"id":"R2567","pred":"aux","subj":"T4014","obj":"T4015"},{"id":"R2568","pred":"conj","subj":"T4015","obj":"T4010"},{"id":"R2569","pred":"det","subj":"T4016","obj":"T4017"},{"id":"R2570","pred":"dobj","subj":"T4017","obj":"T4015"},{"id":"R2571","pred":"advmod","subj":"T4018","obj":"T4019"},{"id":"R2572","pred":"nummod","subj":"T4019","obj":"T4023"},{"id":"R2573","pred":"advmod","subj":"T4020","obj":"T4019"},{"id":"R2574","pred":"advmod","subj":"T4021","obj":"T4019"},{"id":"R2575","pred":"quantmod","subj":"T4022","obj":"T4019"},{"id":"R2576","pred":"npadvmod","subj":"T4023","obj":"T4015"},{"id":"R2577","pred":"prep","subj":"T4024","obj":"T4015"},{"id":"R2578","pred":"det","subj":"T4025","obj":"T4026"},{"id":"R2579","pred":"pobj","subj":"T4026","obj":"T4024"},{"id":"R2580","pred":"prep","subj":"T4027","obj":"T4026"},{"id":"R2581","pred":"det","subj":"T4028","obj":"T4029"},{"id":"R2582","pred":"pobj","subj":"T4029","obj":"T4027"},{"id":"R2583","pred":"punct","subj":"T4030","obj":"T3996"},{"id":"R2584","pred":"advmod","subj":"T4032","obj":"T4033"},{"id":"R2585","pred":"punct","subj":"T4034","obj":"T4033"},{"id":"R2586","pred":"det","subj":"T4035","obj":"T4036"},{"id":"R2587","pred":"nsubj","subj":"T4036","obj":"T4033"},{"id":"R2588","pred":"amod","subj":"T4037","obj":"T4038"},{"id":"R2589","pred":"amod","subj":"T4038","obj":"T4036"},{"id":"R2590","pred":"punct","subj":"T4039","obj":"T4038"},{"id":"R2591","pred":"prep","subj":"T4040","obj":"T4036"},{"id":"R2592","pred":"pobj","subj":"T4041","obj":"T4040"},{"id":"R2593","pred":"aux","subj":"T4042","obj":"T4033"},{"id":"R2594","pred":"neg","subj":"T4043","obj":"T4033"},{"id":"R2595","pred":"det","subj":"T4044","obj":"T4045"},{"id":"R2596","pred":"dobj","subj":"T4045","obj":"T4033"},{"id":"R2597","pred":"prep","subj":"T4046","obj":"T4045"},{"id":"R2598","pred":"pobj","subj":"T4047","obj":"T4046"},{"id":"R2599","pred":"acl","subj":"T4048","obj":"T4045"},{"id":"R2600","pred":"prep","subj":"T4049","obj":"T4048"},{"id":"R2601","pred":"nmod","subj":"T4050","obj":"T4051"},{"id":"R2602","pred":"pobj","subj":"T4051","obj":"T4049"},{"id":"R2603","pred":"cc","subj":"T4052","obj":"T4050"},{"id":"R2604","pred":"compound","subj":"T4053","obj":"T4054"},{"id":"R2605","pred":"conj","subj":"T4054","obj":"T4050"},{"id":"R2606","pred":"amod","subj":"T4055","obj":"T4051"},{"id":"R2607","pred":"mark","subj":"T4056","obj":"T4057"},{"id":"R2608","pred":"advcl","subj":"T4057","obj":"T4033"},{"id":"R2609","pred":"nsubj","subj":"T4058","obj":"T4057"},{"id":"R2610","pred":"prep","subj":"T4059","obj":"T4057"},{"id":"R2611","pred":"nmod","subj":"T4060","obj":"T4061"},{"id":"R2612","pred":"pobj","subj":"T4061","obj":"T4059"},{"id":"R2613","pred":"amod","subj":"T4062","obj":"T4061"},{"id":"R2614","pred":"prep","subj":"T4063","obj":"T4057"},{"id":"R2615","pred":"pobj","subj":"T4064","obj":"T4063"},{"id":"R2616","pred":"punct","subj":"T4065","obj":"T4033"},{"id":"R6561","pred":"det","subj":"T9944","obj":"T9945"},{"id":"R6562","pred":"nsubjpass","subj":"T9945","obj":"T9946"},{"id":"R6563","pred":"prep","subj":"T9947","obj":"T9945"},{"id":"R6564","pred":"amod","subj":"T9948","obj":"T9949"},{"id":"R6565","pred":"pobj","subj":"T9949","obj":"T9947"},{"id":"R6566","pred":"auxpass","subj":"T9950","obj":"T9946"},{"id":"R6567","pred":"prep","subj":"T9951","obj":"T9946"},{"id":"R6568","pred":"amod","subj":"T9952","obj":"T9953"},{"id":"R6569","pred":"amod","subj":"T9953","obj":"T9955"},{"id":"R6570","pred":"punct","subj":"T9954","obj":"T9953"},{"id":"R6571","pred":"amod","subj":"T9955","obj":"T9956"},{"id":"R6572","pred":"pobj","subj":"T9956","obj":"T9951"},{"id":"R6573","pred":"nmod","subj":"T9957","obj":"T9956"},{"id":"R6574","pred":"amod","subj":"T9958","obj":"T9956"},{"id":"R6575","pred":"amod","subj":"T9959","obj":"T9956"},{"id":"R6576","pred":"punct","subj":"T9960","obj":"T9946"},{"id":"R6577","pred":"prep","subj":"T9962","obj":"T9963"},{"id":"R6578","pred":"prep","subj":"T9964","obj":"T9962"},{"id":"R6579","pred":"compound","subj":"T9965","obj":"T9966"},{"id":"R6580","pred":"pobj","subj":"T9966","obj":"T9964"},{"id":"R6581","pred":"expl","subj":"T9967","obj":"T9963"},{"id":"R6582","pred":"det","subj":"T9968","obj":"T9969"},{"id":"R6583","pred":"attr","subj":"T9969","obj":"T9963"},{"id":"R6584","pred":"amod","subj":"T9970","obj":"T9969"},{"id":"R6585","pred":"prep","subj":"T9971","obj":"T9969"},{"id":"R6586","pred":"compound","subj":"T9972","obj":"T9973"},{"id":"R6587","pred":"pobj","subj":"T9973","obj":"T9971"},{"id":"R6588","pred":"prep","subj":"T9974","obj":"T9973"},{"id":"R6589","pred":"amod","subj":"T9975","obj":"T9976"},{"id":"R6590","pred":"pobj","subj":"T9976","obj":"T9974"},{"id":"R6591","pred":"amod","subj":"T9977","obj":"T9976"},{"id":"R6592","pred":"punct","subj":"T9978","obj":"T9963"},{"id":"R6593","pred":"cc","subj":"T9979","obj":"T9963"},{"id":"R6594","pred":"nsubjpass","subj":"T9980","obj":"T9981"},{"id":"R6595","pred":"conj","subj":"T9981","obj":"T9963"},{"id":"R6596","pred":"aux","subj":"T9982","obj":"T9981"},{"id":"R6597","pred":"auxpass","subj":"T9983","obj":"T9981"},{"id":"R6598","pred":"prep","subj":"T9984","obj":"T9981"},{"id":"R6599","pred":"det","subj":"T9985","obj":"T9986"},{"id":"R6600","pred":"pobj","subj":"T9986","obj":"T9984"},{"id":"R6601","pred":"amod","subj":"T9987","obj":"T9986"},{"id":"R6602","pred":"punct","subj":"T9988","obj":"T9989"},{"id":"R6603","pred":"parataxis","subj":"T9989","obj":"T9981"},{"id":"R6604","pred":"nmod","subj":"T9990","obj":"T9989"},{"id":"R6605","pred":"punct","subj":"T9991","obj":"T9989"},{"id":"R6606","pred":"punct","subj":"T9992","obj":"T9989"},{"id":"R6607","pred":"punct","subj":"T9993","obj":"T9981"},{"id":"R6608","pred":"amod","subj":"T9995","obj":"T9996"},{"id":"R6609","pred":"nsubj","subj":"T9996","obj":"T9997"},{"id":"R6610","pred":"prep","subj":"T9998","obj":"T9996"},{"id":"R6611","pred":"pobj","subj":"T9999","obj":"T9998"},{"id":"R6612","pred":"punct","subj":"T10000","obj":"T10001"},{"id":"R6613","pred":"parataxis","subj":"T10001","obj":"T9996"},{"id":"R6614","pred":"punct","subj":"T10002","obj":"T10001"},{"id":"R6615","pred":"dobj","subj":"T10003","obj":"T9997"},{"id":"R6616","pred":"prep","subj":"T10004","obj":"T10003"},{"id":"R6617","pred":"det","subj":"T10005","obj":"T10006"},{"id":"R6618","pred":"pobj","subj":"T10006","obj":"T10004"},{"id":"R6619","pred":"cc","subj":"T10007","obj":"T10006"},{"id":"R6620","pred":"amod","subj":"T10008","obj":"T10009"},{"id":"R6621","pred":"conj","subj":"T10009","obj":"T10006"},{"id":"R6622","pred":"compound","subj":"T10010","obj":"T10009"},{"id":"R6623","pred":"punct","subj":"T10011","obj":"T9997"},{"id":"R6624","pred":"det","subj":"T10013","obj":"T10014"},{"id":"R6625","pred":"nsubj","subj":"T10014","obj":"T10015"},{"id":"R6626","pred":"det","subj":"T10016","obj":"T10017"},{"id":"R6627","pred":"dobj","subj":"T10017","obj":"T10015"},{"id":"R6628","pred":"advmod","subj":"T10018","obj":"T10019"},{"id":"R6629","pred":"amod","subj":"T10019","obj":"T10017"},{"id":"R6630","pred":"prep","subj":"T10020","obj":"T10017"},{"id":"R6631","pred":"amod","subj":"T10021","obj":"T10022"},{"id":"R6632","pred":"pobj","subj":"T10022","obj":"T10020"},{"id":"R6633","pred":"punct","subj":"T10023","obj":"T10015"},{"id":"R6634","pred":"advmod","subj":"T10024","obj":"T10025"},{"id":"R6635","pred":"prep","subj":"T10025","obj":"T10015"},{"id":"R6636","pred":"det","subj":"T10026","obj":"T10027"},{"id":"R6637","pred":"pobj","subj":"T10027","obj":"T10025"},{"id":"R6638","pred":"punct","subj":"T10028","obj":"T10029"},{"id":"R6639","pred":"parataxis","subj":"T10029","obj":"T10015"},{"id":"R6640","pred":"nmod","subj":"T10030","obj":"T10029"},{"id":"R6641","pred":"punct","subj":"T10031","obj":"T10029"},{"id":"R6642","pred":"punct","subj":"T10032","obj":"T10029"},{"id":"R6643","pred":"punct","subj":"T10033","obj":"T10015"},{"id":"R6644","pred":"advmod","subj":"T10035","obj":"T10036"},{"id":"R6645","pred":"punct","subj":"T10037","obj":"T10036"},{"id":"R6646","pred":"amod","subj":"T10038","obj":"T10039"},{"id":"R6647","pred":"nsubj","subj":"T10039","obj":"T10036"},{"id":"R6648","pred":"amod","subj":"T10040","obj":"T10039"},{"id":"R6649","pred":"acomp","subj":"T10041","obj":"T10036"},{"id":"R6650","pred":"prep","subj":"T10042","obj":"T10036"},{"id":"R6651","pred":"poss","subj":"T10043","obj":"T10044"},{"id":"R6652","pred":"pobj","subj":"T10044","obj":"T10042"},{"id":"R6653","pred":"case","subj":"T10045","obj":"T10043"},{"id":"R6654","pred":"punct","subj":"T10046","obj":"T10047"},{"id":"R6655","pred":"parataxis","subj":"T10047","obj":"T10036"},{"id":"R6656","pred":"nmod","subj":"T10048","obj":"T10047"},{"id":"R6657","pred":"punct","subj":"T10049","obj":"T10047"},{"id":"R6658","pred":"punct","subj":"T10050","obj":"T10047"},{"id":"R6659","pred":"cc","subj":"T10051","obj":"T10036"},{"id":"R6660","pred":"nsubj","subj":"T10052","obj":"T10053"},{"id":"R6661","pred":"conj","subj":"T10053","obj":"T10036"},{"id":"R6662","pred":"prep","subj":"T10054","obj":"T10053"},{"id":"R6663","pred":"det","subj":"T10055","obj":"T10056"},{"id":"R6664","pred":"pobj","subj":"T10056","obj":"T10054"},{"id":"R6665","pred":"prep","subj":"T10057","obj":"T10056"},{"id":"R6666","pred":"pobj","subj":"T10058","obj":"T10057"},{"id":"R6667","pred":"advmod","subj":"T10059","obj":"T10060"},{"id":"R6668","pred":"relcl","subj":"T10060","obj":"T10056"},{"id":"R6669","pred":"nsubj","subj":"T10061","obj":"T10060"},{"id":"R6670","pred":"amod","subj":"T10062","obj":"T10063"},{"id":"R6671","pred":"dobj","subj":"T10063","obj":"T10060"},{"id":"R6672","pred":"prep","subj":"T10064","obj":"T10060"},{"id":"R6673","pred":"det","subj":"T10065","obj":"T10066"},{"id":"R6674","pred":"pobj","subj":"T10066","obj":"T10064"},{"id":"R6675","pred":"amod","subj":"T10067","obj":"T10066"},{"id":"R6676","pred":"punct","subj":"T10068","obj":"T10036"},{"id":"R6677","pred":"nsubj","subj":"T10070","obj":"T10071"},{"id":"R6678","pred":"nummod","subj":"T10072","obj":"T10073"},{"id":"R6679","pred":"dobj","subj":"T10073","obj":"T10071"},{"id":"R6680","pred":"punct","subj":"T10074","obj":"T10071"},{"id":"R2443","pred":"pobj","subj":"T3854","obj":"T3852"},{"id":"R2444","pred":"npadvmod","subj":"T3855","obj":"T3856"},{"id":"R2445","pred":"amod","subj":"T3856","obj":"T3854"},{"id":"R2446","pred":"amod","subj":"T3857","obj":"T3854"},{"id":"R2447","pred":"punct","subj":"T3858","obj":"T3859"},{"id":"R2448","pred":"parataxis","subj":"T3859","obj":"T3833"},{"id":"R2449","pred":"compound","subj":"T3860","obj":"T3859"},{"id":"R2450","pred":"punct","subj":"T3861","obj":"T3859"},{"id":"R2451","pred":"punct","subj":"T3862","obj":"T3833"},{"id":"R2452","pred":"advmod","subj":"T3864","obj":"T3865"},{"id":"R2453","pred":"punct","subj":"T3866","obj":"T3865"},{"id":"R2454","pred":"det","subj":"T3867","obj":"T3868"},{"id":"R2455","pred":"nsubjpass","subj":"T3868","obj":"T3865"},{"id":"R2456","pred":"aux","subj":"T3869","obj":"T3865"},{"id":"R2457","pred":"neg","subj":"T3870","obj":"T3865"},{"id":"R2458","pred":"auxpass","subj":"T3871","obj":"T3865"},{"id":"R2459","pred":"advmod","subj":"T3872","obj":"T3865"},{"id":"R2460","pred":"prep","subj":"T3873","obj":"T3865"},{"id":"R2461","pred":"amod","subj":"T3874","obj":"T3875"},{"id":"R2462","pred":"pobj","subj":"T3875","obj":"T3873"},{"id":"R2463","pred":"compound","subj":"T3876","obj":"T3875"},{"id":"R2464","pred":"prep","subj":"T3877","obj":"T3865"},{"id":"R2465","pred":"prep","subj":"T3878","obj":"T3877"},{"id":"R2466","pred":"poss","subj":"T3879","obj":"T3880"},{"id":"R2467","pred":"pobj","subj":"T3880","obj":"T3878"},{"id":"R2468","pred":"punct","subj":"T3881","obj":"T3865"},{"id":"R2469","pred":"nsubj","subj":"T3896","obj":"T3897"},{"id":"R2470","pred":"dobj","subj":"T3898","obj":"T3897"},{"id":"R2471","pred":"nsubj","subj":"T3909","obj":"T3910"},{"id":"R2472","pred":"advmod","subj":"T3911","obj":"T3912"},{"id":"R2473","pred":"appos","subj":"T3912","obj":"T3909"},{"id":"R2474","pred":"det","subj":"T3913","obj":"T3912"},{"id":"R2475","pred":"punct","subj":"T3914","obj":"T3910"},{"id":"R2476","pred":"amod","subj":"T3915","obj":"T3916"},{"id":"R2477","pred":"dobj","subj":"T3916","obj":"T3910"},{"id":"R2478","pred":"amod","subj":"T3917","obj":"T3916"},{"id":"R2479","pred":"punct","subj":"T3918","obj":"T3916"},{"id":"R2480","pred":"dep","subj":"T3919","obj":"T3920"},{"id":"R2481","pred":"relcl","subj":"T3920","obj":"T3916"},{"id":"R2482","pred":"det","subj":"T3921","obj":"T3922"}],"text":"6 months Brn3c null mutants\nVery few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology.\nFigure 7 The innervation of sensory epithelia is shown in 6-month old Brn3c null mutant mice. Compared to P8 animals there is a further reduction of fiber density to vestibular sensory epithelia, but fibers can be traced to all sensory epithelia (a,b). Transcellular labeling with DiI (b) suggest contacts between these afferents and immature hair cells. The cochlea shows a much reduced density of radial bundles, even in the apex (c,d). However, spiral sensory neurons are present in Rosenthal's canal (c,d) and fibers extend to the organ of Corti where they form longitudinal tracts in the immature epithelium. Bar indicates 100 μm. The cochlea, most prominently the apex, receives many afferent fibers, which form an interrupted inner spiral bundle (Fig. 7c). Some of the radial fiber bundles are myelinated (Fig. 7d). Only an occasional fiber extends beyond the inner spiral bundle into the area of the outer hair cells (Fig. 7d). Even at this late stage in maturation there are still numerous spiral neurons present in the apex (Fig. 7c,7d).\nIn summary, these tracing data suggest that mature hair cells are not necessary to direct fiber outgrowth and to maintain some fibers at least up to 6 months in the apex of the cochlea. Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T9917","span":{"begin":1424,"end":1434},"obj":"UBERON:0000483"},{"id":"T9916","span":{"begin":1401,"end":1407},"obj":"UBERON:0001018"},{"id":"T9915","span":{"begin":1357,"end":1371},"obj":"UBERON:0002227"},{"id":"T9914","span":{"begin":1308,"end":1325},"obj":"UBERON:0006106"},{"id":"T9913","span":{"begin":1277,"end":1292},"obj":"CL:0000101"},{"id":"T9912","span":{"begin":1285,"end":1292},"obj":"CL:0011113"},{"id":"T9911","span":{"begin":1270,"end":1276},"obj":"_FRAGMENT"},{"id":"T9910","span":{"begin":1181,"end":1188},"obj":"UBERON:0001844"},{"id":"T9909","span":{"begin":1165,"end":1175},"obj":"CL:0000855"},{"id":"T9908","span":{"begin":1103,"end":1106},"obj":"CHEBI:52029"},{"id":"T9907","span":{"begin":1050,"end":1067},"obj":"UBERON:0006934"},{"id":"T9906","span":{"begin":988,"end":1016},"obj":"UBERON:0006932"},{"id":"T9905","span":{"begin":931,"end":938},"obj":"NCBITaxon:33208"},{"id":"T9904","span":{"begin":910,"end":914},"obj":"NCBITaxon:10088"},{"id":"T9903","span":{"begin":892,"end":897},"obj":"PR:000013043"},{"id":"T9902","span":{"begin":850,"end":867},"obj":"UBERON:0006934"},{"id":"T3665","span":{"begin":2250,"end":2255},"obj":"GO:0007567"},{"id":"T3664","span":{"begin":2239,"end":2243},"obj":"NCBITaxon:10088"},{"id":"T3663","span":{"begin":2226,"end":2231},"obj":"PR:000013043"},{"id":"T3662","span":{"begin":2173,"end":2185},"obj":"PR:000021998"},{"id":"T3661","span":{"begin":2156,"end":2168},"obj":"PR:000021998"},{"id":"T3660","span":{"begin":2047,"end":2054},"obj":"UBERON:0002819"},{"id":"T3659","span":{"begin":2035,"end":2042},"obj":"_FRAGMENT"},{"id":"T3658","span":{"begin":1921,"end":1931},"obj":"CL:0000855"},{"id":"T3657","span":{"begin":1821,"end":1835},"obj":"CL:0011113"},{"id":"T3656","span":{"begin":1730,"end":1746},"obj":"CL:0000601"},{"id":"T3655","span":{"begin":1485,"end":1486},"obj":"UBERON:0001844"},{"id":"T3654","span":{"begin":1478,"end":1479},"obj":"CL:0000101"},{"id":"T3653","span":{"begin":1472,"end":1473},"obj":"UBERON:0001844"},{"id":"T3652","span":{"begin":1465,"end":1467},"obj":"UBERON:0006932"},{"id":"T3651","span":{"begin":1462,"end":1463},"obj":"PR:000013043"},{"id":"T3650","span":{"begin":783,"end":793},"obj":"CL:0000855"},{"id":"T3649","span":{"begin":699,"end":706},"obj":"UBERON:0001853"},{"id":"T3648","span":{"begin":681,"end":686},"obj":"PR:000013043"},{"id":"T3647","span":{"begin":617,"end":620},"obj":"CHEBI:52029"},{"id":"T3646","span":{"begin":569,"end":573},"obj":"NCBITaxon:10088"},{"id":"T3645","span":{"begin":485,"end":494},"obj":"UBERON:0000483"},{"id":"T3644","span":{"begin":466,"end":475},"obj":"UBERON:0006798"},{"id":"T3643","span":{"begin":436,"end":443},"obj":"UBERON:0001854"},{"id":"T3642","span":{"begin":424,"end":431},"obj":"UBERON:0001853"},{"id":"T3641","span":{"begin":358,"end":374},"obj":"UBERON:0001843"},{"id":"T3640","span":{"begin":329,"end":338},"obj":"UBERON:0000483"},{"id":"T3639","span":{"begin":323,"end":328},"obj":"UBERON:0000025"},{"id":"T3638","span":{"begin":300,"end":315},"obj":"CL:0000101"},{"id":"T3637","span":{"begin":197,"end":202},"obj":"PR:000013043"},{"id":"T3636","span":{"begin":80,"end":100},"obj":"UBERON:0006932"},{"id":"T3635","span":{"begin":63,"end":71},"obj":"UBERON:0006798"},{"id":"T3634","span":{"begin":9,"end":14},"obj":"PR:000013043"}],"relations":[{"id":"R6559","pred":"_lexicallyChainedTo","subj":"T9912","obj":"T9911"},{"id":"R2319","pred":"_lexicallyChainedTo","subj":"T3660","obj":"T3659"}],"text":"6 months Brn3c null mutants\nVery few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology.\nFigure 7 The innervation of sensory epithelia is shown in 6-month old Brn3c null mutant mice. Compared to P8 animals there is a further reduction of fiber density to vestibular sensory epithelia, but fibers can be traced to all sensory epithelia (a,b). Transcellular labeling with DiI (b) suggest contacts between these afferents and immature hair cells. The cochlea shows a much reduced density of radial bundles, even in the apex (c,d). However, spiral sensory neurons are present in Rosenthal's canal (c,d) and fibers extend to the organ of Corti where they form longitudinal tracts in the immature epithelium. Bar indicates 100 μm. The cochlea, most prominently the apex, receives many afferent fibers, which form an interrupted inner spiral bundle (Fig. 7c). Some of the radial fiber bundles are myelinated (Fig. 7d). Only an occasional fiber extends beyond the inner spiral bundle into the area of the outer hair cells (Fig. 7d). Even at this late stage in maturation there are still numerous spiral neurons present in the apex (Fig. 7c,7d).\nIn summary, these tracing data suggest that mature hair cells are not necessary to direct fiber outgrowth and to maintain some fibers at least up to 6 months in the apex of the cochlea. Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T9921","span":{"begin":892,"end":897},"obj":"PR_EXT:000013043"},{"id":"T9943","span":{"begin":1424,"end":1434},"obj":"UBERON:0000483"},{"id":"T9942","span":{"begin":1401,"end":1407},"obj":"UBERON:0001018"},{"id":"T9941","span":{"begin":1357,"end":1371},"obj":"UBERON:0002227"},{"id":"T9940","span":{"begin":1308,"end":1325},"obj":"UBERON:0006106"},{"id":"T9939","span":{"begin":1277,"end":1292},"obj":"CL:0000101"},{"id":"T9938","span":{"begin":1277,"end":1284},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T9937","span":{"begin":1285,"end":1292},"obj":"CL:0011113"},{"id":"T9936","span":{"begin":1270,"end":1276},"obj":"_FRAGMENT"},{"id":"T9935","span":{"begin":1181,"end":1188},"obj":"UBERON:0001844"},{"id":"T9934","span":{"begin":1170,"end":1175},"obj":"CL_GO_EXT:cell"},{"id":"T9933","span":{"begin":1165,"end":1175},"obj":"CL:0000855"},{"id":"T9932","span":{"begin":1103,"end":1106},"obj":"CHEBI:52029"},{"id":"T9931","span":{"begin":1089,"end":1097},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T9930","span":{"begin":1080,"end":1088},"obj":"CL_GO_EXT:cell"},{"id":"T9929","span":{"begin":1050,"end":1067},"obj":"UBERON:0006934"},{"id":"T9928","span":{"begin":1050,"end":1057},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T9927","span":{"begin":999,"end":1006},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T9926","span":{"begin":988,"end":1016},"obj":"UBERON:0006932"},{"id":"T9925","span":{"begin":931,"end":938},"obj":"NCBITaxon:33208"},{"id":"T9924","span":{"begin":910,"end":914},"obj":"NCBITaxon:10088"},{"id":"T9923","span":{"begin":903,"end":909},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T9922","span":{"begin":898,"end":902},"obj":"SO_EXT:sequence_nullness"},{"id":"T9920","span":{"begin":850,"end":867},"obj":"UBERON:0006934"},{"id":"T9919","span":{"begin":850,"end":857},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T9918","span":{"begin":835,"end":846},"obj":"GO_UBERON_EXT:innervation_entity_or_process"},{"id":"T3722","span":{"begin":2250,"end":2255},"obj":"GO:0007567"},{"id":"T3721","span":{"begin":2239,"end":2243},"obj":"NCBITaxon:10088"},{"id":"T3720","span":{"begin":2232,"end":2238},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T3719","span":{"begin":2226,"end":2231},"obj":"PR_EXT:000013043"},{"id":"T3718","span":{"begin":2200,"end":2209},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T3717","span":{"begin":2195,"end":2199},"obj":"SO_EXT:sequence_nullness"},{"id":"T3716","span":{"begin":2173,"end":2194},"obj":"GO_EXT:0005030"},{"id":"T3715","span":{"begin":2173,"end":2185},"obj":"PR_EXT:000021998"},{"id":"T3714","span":{"begin":2156,"end":2168},"obj":"PR_EXT:000021998"},{"id":"T3713","span":{"begin":2097,"end":2108},"obj":"GO_UBERON_EXT:innervation_entity_or_process"},{"id":"T3712","span":{"begin":2047,"end":2054},"obj":"UBERON:0002819"},{"id":"T3711","span":{"begin":2035,"end":2042},"obj":"_FRAGMENT"},{"id":"T3710","span":{"begin":1953,"end":1959},"obj":"GO_EXT:biological_direction_or_guidance"},{"id":"T3709","span":{"begin":1926,"end":1931},"obj":"CL_GO_EXT:cell"},{"id":"T3708","span":{"begin":1921,"end":1931},"obj":"CL:0000855"},{"id":"T3707","span":{"begin":1821,"end":1835},"obj":"CL:0011113"},{"id":"T3706","span":{"begin":1785,"end":1795},"obj":"GO_PATO_EXT:biological_maturation"},{"id":"T3705","span":{"begin":1741,"end":1746},"obj":"CL_GO_EXT:cell"},{"id":"T3704","span":{"begin":1730,"end":1746},"obj":"CL:0000601"},{"id":"T3703","span":{"begin":1623,"end":1633},"obj":"GO_EXT:myelin_assembly_or_myelination"},{"id":"T3702","span":{"begin":1485,"end":1486},"obj":"UBERON:0001844"},{"id":"T3679","span":{"begin":329,"end":338},"obj":"UBERON:0000483"},{"id":"T3678","span":{"begin":323,"end":328},"obj":"UBERON:0000025"},{"id":"T3677","span":{"begin":300,"end":315},"obj":"CL:0000101"},{"id":"T3676","span":{"begin":300,"end":307},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T3675","span":{"begin":289,"end":299},"obj":"UBERON_EXT:vestibule_or_vestibular_system"},{"id":"T3674","span":{"begin":208,"end":215},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T3673","span":{"begin":203,"end":207},"obj":"SO_EXT:sequence_nullness"},{"id":"T3672","span":{"begin":197,"end":202},"obj":"PR_EXT:000013043"},{"id":"T3671","span":{"begin":173,"end":184},"obj":"GO_UBERON_EXT:innervation_entity_or_process"},{"id":"T3670","span":{"begin":80,"end":100},"obj":"UBERON:0006932"},{"id":"T3669","span":{"begin":63,"end":71},"obj":"UBERON:0006798"},{"id":"T3668","span":{"begin":20,"end":27},"obj":"SO_EXT:sequence_altered_entity"},{"id":"T3667","span":{"begin":15,"end":19},"obj":"SO_EXT:sequence_nullness"},{"id":"T3666","span":{"begin":9,"end":14},"obj":"PR_EXT:000013043"},{"id":"T3701","span":{"begin":1478,"end":1479},"obj":"CL:0000101"},{"id":"T3700","span":{"begin":1478,"end":1479},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T3699","span":{"begin":1472,"end":1473},"obj":"UBERON:0001844"},{"id":"T3698","span":{"begin":1465,"end":1467},"obj":"UBERON:0006932"},{"id":"T3697","span":{"begin":1462,"end":1463},"obj":"PR_EXT:000013043"},{"id":"T3696","span":{"begin":788,"end":793},"obj":"CL_GO_EXT:cell"},{"id":"T3695","span":{"begin":783,"end":793},"obj":"CL:0000855"},{"id":"T3694","span":{"begin":733,"end":738},"obj":"CL_GO_EXT:cell"},{"id":"T3693","span":{"begin":699,"end":706},"obj":"UBERON:0001853"},{"id":"T3692","span":{"begin":692,"end":698},"obj":"SO_EXT:sequence_altered_entity_or_alteration_process"},{"id":"T3691","span":{"begin":687,"end":691},"obj":"SO_EXT:sequence_nullness"},{"id":"T3690","span":{"begin":681,"end":686},"obj":"PR_EXT:000013043"},{"id":"T3689","span":{"begin":624,"end":629},"obj":"CL_GO_EXT:cell"},{"id":"T3688","span":{"begin":617,"end":620},"obj":"CHEBI:52029"},{"id":"T3687","span":{"begin":603,"end":611},"obj":"CHEBI_SO_EXT:molecular_label_or_mark_or_tag_process"},{"id":"T3686","span":{"begin":594,"end":602},"obj":"CL_GO_EXT:cell"},{"id":"T3685","span":{"begin":569,"end":573},"obj":"NCBITaxon:10088"},{"id":"T3684","span":{"begin":485,"end":494},"obj":"UBERON:0000483"},{"id":"T3683","span":{"begin":466,"end":475},"obj":"UBERON:0006798"},{"id":"T3682","span":{"begin":436,"end":443},"obj":"UBERON:0001854"},{"id":"T3681","span":{"begin":424,"end":431},"obj":"UBERON:0001853"},{"id":"T3680","span":{"begin":358,"end":374},"obj":"UBERON:0001843"}],"relations":[{"id":"R6560","pred":"_lexicallyChainedTo","subj":"T9937","obj":"T9936"},{"id":"R2320","pred":"_lexicallyChainedTo","subj":"T3712","obj":"T3711"}],"text":"6 months Brn3c null mutants\nVery few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b). Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown). Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b). However, these cells could not be clearly identified as immature hair cells based on their morphology.\nFigure 7 The innervation of sensory epithelia is shown in 6-month old Brn3c null mutant mice. Compared to P8 animals there is a further reduction of fiber density to vestibular sensory epithelia, but fibers can be traced to all sensory epithelia (a,b). Transcellular labeling with DiI (b) suggest contacts between these afferents and immature hair cells. The cochlea shows a much reduced density of radial bundles, even in the apex (c,d). However, spiral sensory neurons are present in Rosenthal's canal (c,d) and fibers extend to the organ of Corti where they form longitudinal tracts in the immature epithelium. Bar indicates 100 μm. The cochlea, most prominently the apex, receives many afferent fibers, which form an interrupted inner spiral bundle (Fig. 7c). Some of the radial fiber bundles are myelinated (Fig. 7d). Only an occasional fiber extends beyond the inner spiral bundle into the area of the outer hair cells (Fig. 7d). Even at this late stage in maturation there are still numerous spiral neurons present in the apex (Fig. 7c,7d).\nIn summary, these tracing data suggest that mature hair cells are not necessary to direct fiber outgrowth and to maintain some fibers at least up to 6 months in the apex of the cochlea. Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth."}