PMC:149350 / 28916-29680 JSONTXT

{"project":"craft-ca-core-dev","denotations":[{"id":"T5498","span":{"begin":485,"end":495},"obj":"GO:0010467"},{"id":"T5497","span":{"begin":379,"end":394},"obj":"CL:0000066"},{"id":"T5496","span":{"begin":379,"end":389},"obj":"UBERON:0000483"},{"id":"T5495","span":{"begin":302,"end":308},"obj":"UBERON:4200215"},{"id":"T5494","span":{"begin":286,"end":296},"obj":"GO:0043226"},{"id":"T5493","span":{"begin":243,"end":249},"obj":"UBERON:0001851"},{"id":"T5492","span":{"begin":90,"end":105},"obj":"CL:0000066"},{"id":"T5491","span":{"begin":90,"end":100},"obj":"UBERON:0000483"},{"id":"T5490","span":{"begin":32,"end":52},"obj":"CL:0002224"},{"id":"T5489","span":{"begin":32,"end":47},"obj":"UBERON:0001803"},{"id":"T5488","span":{"begin":10,"end":26},"obj":"GO:0008150"}],"text":"The final biological event in a lens epithelial cell's life is the transformation from an epithelial cell into a fiber cell, which occurs at the equatorial/bow region of the lens. The newly forming fiber cell continues to differentiate in the cortex until a mature fiber cell devoid of organelles with suture formation at the ends of the cell is formed. This entire process from epithelial cell to mature fiber cell is defined as lens differentiation. The precise spatial and temporal expression of the crystallin proteins in the developing lens may not be simply a consequence of the differentiation process, but instead may play an important, if not essential, role in the differentiation process itself. The results of the current study support this hypothesis."}

{"project":"craft-sa-dev","denotations":[{"id":"T7158","span":{"begin":456,"end":463},"obj":"JJ"},{"id":"T7157","span":{"begin":485,"end":495},"obj":"NN"},{"id":"T7156","span":{"begin":452,"end":455},"obj":"DT"},{"id":"T7155","span":{"begin":451,"end":706},"obj":"sentence"},{"id":"T7154","span":{"begin":450,"end":451},"obj":"."},{"id":"T7153","span":{"begin":435,"end":450},"obj":"NN"},{"id":"T7152","span":{"begin":430,"end":434},"obj":"NN"},{"id":"T7151","span":{"begin":427,"end":429},"obj":"IN"},{"id":"T7150","span":{"begin":416,"end":418},"obj":"VBZ"},{"id":"T7149","span":{"begin":405,"end":410},"obj":"NN"},{"id":"T7148","span":{"begin":411,"end":415},"obj":"NN"},{"id":"T7147","span":{"begin":398,"end":404},"obj":"JJ"},{"id":"T7146","span":{"begin":395,"end":397},"obj":"IN"},{"id":"T7145","span":{"begin":390,"end":394},"obj":"NN"},{"id":"T7144","span":{"begin":379,"end":389},"obj":"JJ"},{"id":"T7143","span":{"begin":374,"end":378},"obj":"IN"},{"id":"T7142","span":{"begin":419,"end":426},"obj":"VBN"},{"id":"T7141","span":{"begin":359,"end":365},"obj":"JJ"},{"id":"T7140","span":{"begin":366,"end":373},"obj":"NN"},{"id":"T7139","span":{"begin":354,"end":358},"obj":"DT"},{"id":"T7138","span":{"begin":353,"end":451},"obj":"sentence"},{"id":"T7137","span":{"begin":352,"end":353},"obj":"."},{"id":"T7136","span":{"begin":343,"end":345},"obj":"VBZ"},{"id":"T7135","span":{"begin":338,"end":342},"obj":"NN"},{"id":"T7134","span":{"begin":334,"end":337},"obj":"DT"},{"id":"T7133","span":{"begin":331,"end":333},"obj":"IN"},{"id":"T7132","span":{"begin":326,"end":330},"obj":"NNS"},{"id":"T7131","span":{"begin":322,"end":325},"obj":"DT"},{"id":"T7130","span":{"begin":319,"end":321},"obj":"IN"},{"id":"T7129","span":{"begin":309,"end":318},"obj":"NN"},{"id":"T7128","span":{"begin":302,"end":308},"obj":"NN"},{"id":"T7127","span":{"begin":297,"end":301},"obj":"IN"},{"id":"T7126","span":{"begin":286,"end":296},"obj":"NNS"},{"id":"T7125","span":{"begin":283,"end":285},"obj":"IN"},{"id":"T7124","span":{"begin":276,"end":282},"obj":"JJ"},{"id":"T7123","span":{"begin":265,"end":270},"obj":"NN"},{"id":"T7122","span":{"begin":258,"end":264},"obj":"JJ"},{"id":"T7121","span":{"begin":271,"end":275},"obj":"NN"},{"id":"T7120","span":{"begin":256,"end":257},"obj":"DT"},{"id":"T7119","span":{"begin":346,"end":352},"obj":"VBN"},{"id":"T7118","span":{"begin":250,"end":255},"obj":"IN"},{"id":"T7117","span":{"begin":243,"end":249},"obj":"NN"},{"id":"T7116","span":{"begin":239,"end":242},"obj":"DT"},{"id":"T7115","span":{"begin":236,"end":238},"obj":"IN"},{"id":"T7114","span":{"begin":222,"end":235},"obj":"VB"},{"id":"T7113","span":{"begin":219,"end":221},"obj":"TO"},{"id":"T7112","span":{"begin":209,"end":218},"obj":"VBZ"},{"id":"T7111","span":{"begin":198,"end":203},"obj":"NN"},{"id":"T7110","span":{"begin":190,"end":197},"obj":"VBG"},{"id":"T7109","span":{"begin":184,"end":189},"obj":"RB"},{"id":"T7108","span":{"begin":204,"end":208},"obj":"NN"},{"id":"T7107","span":{"begin":180,"end":183},"obj":"DT"},{"id":"T7106","span":{"begin":179,"end":353},"obj":"sentence"},{"id":"T7105","span":{"begin":178,"end":179},"obj":"."},{"id":"T7104","span":{"begin":174,"end":178},"obj":"NN"},{"id":"T7103","span":{"begin":170,"end":173},"obj":"DT"},{"id":"T7102","span":{"begin":167,"end":169},"obj":"IN"},{"id":"T7101","span":{"begin":155,"end":156},"obj":"HYPH"},{"id":"T7100","span":{"begin":156,"end":159},"obj":"JJ"},{"id":"T7099","span":{"begin":145,"end":155},"obj":"JJ"},{"id":"T7098","span":{"begin":160,"end":166},"obj":"NN"},{"id":"T7097","span":{"begin":141,"end":144},"obj":"DT"},{"id":"T7096","span":{"begin":138,"end":140},"obj":"IN"},{"id":"T7095","span":{"begin":131,"end":137},"obj":"VBZ"},{"id":"T7094","span":{"begin":125,"end":130},"obj":"WDT"},{"id":"T7093","span":{"begin":123,"end":125},"obj":","},{"id":"T7092","span":{"begin":113,"end":118},"obj":"NN"},{"id":"T7091","span":{"begin":119,"end":123},"obj":"NN"},{"id":"T7090","span":{"begin":111,"end":112},"obj":"DT"},{"id":"T7089","span":{"begin":106,"end":110},"obj":"IN"},{"id":"T7088","span":{"begin":90,"end":100},"obj":"JJ"},{"id":"T7087","span":{"begin":101,"end":105},"obj":"NN"},{"id":"T7086","span":{"begin":87,"end":89},"obj":"DT"},{"id":"T7085","span":{"begin":82,"end":86},"obj":"IN"},{"id":"T7084","span":{"begin":67,"end":81},"obj":"NN"},{"id":"T7083","span":{"begin":63,"end":66},"obj":"DT"},{"id":"T7082","span":{"begin":52,"end":54},"obj":"POS"},{"id":"T7081","span":{"begin":55,"end":59},"obj":"NN"},{"id":"T7080","span":{"begin":37,"end":47},"obj":"JJ"},{"id":"T7079","span":{"begin":32,"end":36},"obj":"NN"},{"id":"T7078","span":{"begin":48,"end":52},"obj":"NN"},{"id":"T7077","span":{"begin":30,"end":31},"obj":"DT"},{"id":"T7076","span":{"begin":27,"end":29},"obj":"IN"},{"id":"T7075","span":{"begin":60,"end":62},"obj":"VBZ"},{"id":"T7074","span":{"begin":10,"end":20},"obj":"JJ"},{"id":"T7073","span":{"begin":4,"end":9},"obj":"JJ"},{"id":"T7072","span":{"begin":21,"end":26},"obj":"NN"},{"id":"T7071","span":{"begin":0,"end":3},"obj":"DT"},{"id":"T7209","span":{"begin":763,"end":764},"obj":"."},{"id":"T7208","span":{"begin":753,"end":763},"obj":"NN"},{"id":"T7207","span":{"begin":748,"end":752},"obj":"DT"},{"id":"T7206","span":{"begin":726,"end":733},"obj":"JJ"},{"id":"T7205","span":{"begin":734,"end":739},"obj":"NN"},{"id":"T7204","span":{"begin":722,"end":725},"obj":"DT"},{"id":"T7203","span":{"begin":719,"end":721},"obj":"IN"},{"id":"T7202","span":{"begin":740,"end":747},"obj":"VBP"},{"id":"T7201","span":{"begin":711,"end":718},"obj":"NNS"},{"id":"T7200","span":{"begin":707,"end":710},"obj":"DT"},{"id":"T7199","span":{"begin":706,"end":764},"obj":"sentence"},{"id":"T7198","span":{"begin":705,"end":706},"obj":"."},{"id":"T7197","span":{"begin":699,"end":705},"obj":"PRP"},{"id":"T7196","span":{"begin":675,"end":690},"obj":"NN"},{"id":"T7195","span":{"begin":691,"end":698},"obj":"NN"},{"id":"T7194","span":{"begin":671,"end":674},"obj":"DT"},{"id":"T7193","span":{"begin":668,"end":670},"obj":"IN"},{"id":"T7192","span":{"begin":661,"end":663},"obj":","},{"id":"T7191","span":{"begin":652,"end":661},"obj":"JJ"},{"id":"T7190","span":{"begin":648,"end":651},"obj":"RB"},{"id":"T7189","span":{"begin":645,"end":647},"obj":"IN"},{"id":"T7188","span":{"begin":643,"end":645},"obj":","},{"id":"T7187","span":{"begin":634,"end":643},"obj":"JJ"},{"id":"T7186","span":{"begin":663,"end":667},"obj":"NN"},{"id":"T7185","span":{"begin":631,"end":633},"obj":"DT"},{"id":"T7184","span":{"begin":622,"end":625},"obj":"MD"},{"id":"T7183","span":{"begin":626,"end":630},"obj":"VB"},{"id":"T7182","span":{"begin":614,"end":621},"obj":"RB"},{"id":"T7181","span":{"begin":610,"end":613},"obj":"CC"},{"id":"T7180","span":{"begin":608,"end":610},"obj":","},{"id":"T7179","span":{"begin":585,"end":600},"obj":"NN"},{"id":"T7178","span":{"begin":601,"end":608},"obj":"NN"},{"id":"T7177","span":{"begin":581,"end":584},"obj":"DT"},{"id":"T7176","span":{"begin":578,"end":580},"obj":"IN"},{"id":"T7175","span":{"begin":566,"end":577},"obj":"NN"},{"id":"T7174","span":{"begin":564,"end":565},"obj":"DT"},{"id":"T7173","span":{"begin":557,"end":563},"obj":"RB"},{"id":"T7172","span":{"begin":550,"end":553},"obj":"RB"},{"id":"T7171","span":{"begin":546,"end":549},"obj":"MD"},{"id":"T7170","span":{"begin":530,"end":540},"obj":"VBG"},{"id":"T7169","span":{"begin":541,"end":545},"obj":"NN"},{"id":"T7168","span":{"begin":526,"end":529},"obj":"DT"},{"id":"T7167","span":{"begin":523,"end":525},"obj":"IN"},{"id":"T7166","span":{"begin":503,"end":513},"obj":"NN"},{"id":"T7165","span":{"begin":514,"end":522},"obj":"NN"},{"id":"T7164","span":{"begin":499,"end":502},"obj":"DT"},{"id":"T7163","span":{"begin":496,"end":498},"obj":"IN"},{"id":"T7162","span":{"begin":554,"end":556},"obj":"VB"},{"id":"T7161","span":{"begin":476,"end":484},"obj":"JJ"},{"id":"T7160","span":{"begin":472,"end":475},"obj":"CC"},{"id":"T7159","span":{"begin":464,"end":471},"obj":"JJ"}],"relations":[{"id":"R4631","pred":"prep","subj":"T7085","obj":"T7084"},{"id":"R4633","pred":"det","subj":"T7086","obj":"T7087"},{"id":"R4634","pred":"pobj","subj":"T7087","obj":"T7085"},{"id":"R4635","pred":"amod","subj":"T7088","obj":"T7087"},{"id":"R4636","pred":"prep","subj":"T7089","obj":"T7084"},{"id":"R4638","pred":"det","subj":"T7090","obj":"T7091"},{"id":"R4639","pred":"pobj","subj":"T7091","obj":"T7089"},{"id":"R4640","pred":"compound","subj":"T7092","obj":"T7091"},{"id":"R4643","pred":"punct","subj":"T7093","obj":"T7084"},{"id":"R4644","pred":"dep","subj":"T7094","obj":"T7095"},{"id":"R4645","pred":"relcl","subj":"T7095","obj":"T7084"},{"id":"R4647","pred":"prep","subj":"T7096","obj":"T7095"},{"id":"R4648","pred":"det","subj":"T7097","obj":"T7098"},{"id":"R4650","pred":"pobj","subj":"T7098","obj":"T7096"},{"id":"R4651","pred":"amod","subj":"T7099","obj":"T7100"},{"id":"R4652","pred":"amod","subj":"T7100","obj":"T7098"},{"id":"R4654","pred":"punct","subj":"T7101","obj":"T7100"},{"id":"R4655","pred":"prep","subj":"T7102","obj":"T7098"},{"id":"R4657","pred":"det","subj":"T7103","obj":"T7104"},{"id":"R4658","pred":"pobj","subj":"T7104","obj":"T7102"},{"id":"R4660","pred":"punct","subj":"T7105","obj":"T7075"},{"id":"R4661","pred":"det","subj":"T7107","obj":"T7108"},{"id":"R4663","pred":"nsubj","subj":"T7108","obj":"T7112"},{"id":"R4664","pred":"advmod","subj":"T7109","obj":"T7110"},{"id":"R4665","pred":"amod","subj":"T7110","obj":"T7108"},{"id":"R4667","pred":"compound","subj":"T7111","obj":"T7108"},{"id":"R4669","pred":"aux","subj":"T7113","obj":"T7114"},{"id":"R4670","pred":"xcomp","subj":"T7114","obj":"T7112"},{"id":"R4671","pred":"prep","subj":"T7115","obj":"T7114"},{"id":"R4672","pred":"det","subj":"T7116","obj":"T7117"},{"id":"R4674","pred":"pobj","subj":"T7117","obj":"T7115"},{"id":"R4675","pred":"mark","subj":"T7118","obj":"T7119"},{"id":"R4676","pred":"advcl","subj":"T7119","obj":"T7114"},{"id":"R4677","pred":"det","subj":"T7120","obj":"T7121"},{"id":"R4678","pred":"nsubjpass","subj":"T7121","obj":"T7119"},{"id":"R4680","pred":"amod","subj":"T7122","obj":"T7121"},{"id":"R4681","pred":"compound","subj":"T7123","obj":"T7121"},{"id":"R4682","pred":"amod","subj":"T7124","obj":"T7121"},{"id":"R4683","pred":"prep","subj":"T7125","obj":"T7124"},{"id":"R4685","pred":"pobj","subj":"T7126","obj":"T7125"},{"id":"R4686","pred":"prep","subj":"T7127","obj":"T7121"},{"id":"R4687","pred":"compound","subj":"T7128","obj":"T7129"},{"id":"R4689","pred":"pobj","subj":"T7129","obj":"T7127"},{"id":"R4690","pred":"prep","subj":"T7130","obj":"T7129"},{"id":"R4692","pred":"det","subj":"T7131","obj":"T7132"},{"id":"R4693","pred":"pobj","subj":"T7132","obj":"T7130"},{"id":"R4694","pred":"prep","subj":"T7133","obj":"T7132"},{"id":"R4695","pred":"det","subj":"T7134","obj":"T7135"},{"id":"R4696","pred":"pobj","subj":"T7135","obj":"T7133"},{"id":"R4698","pred":"auxpass","subj":"T7136","obj":"T7119"},{"id":"R4699","pred":"punct","subj":"T7137","obj":"T7112"},{"id":"R4701","pred":"det","subj":"T7139","obj":"T7140"},{"id":"R4702","pred":"nsubjpass","subj":"T7140","obj":"T7142"},{"id":"R4703","pred":"amod","subj":"T7141","obj":"T7140"},{"id":"R4705","pred":"prep","subj":"T7143","obj":"T7140"},{"id":"R4707","pred":"amod","subj":"T7144","obj":"T7145"},{"id":"R4709","pred":"pobj","subj":"T7145","obj":"T7143"},{"id":"R4710","pred":"prep","subj":"T7146","obj":"T7140"},{"id":"R4711","pred":"amod","subj":"T7147","obj":"T7148"},{"id":"R4713","pred":"pobj","subj":"T7148","obj":"T7146"},{"id":"R4714","pred":"compound","subj":"T7149","obj":"T7148"},{"id":"R4715","pred":"auxpass","subj":"T7150","obj":"T7142"},{"id":"R4717","pred":"prep","subj":"T7151","obj":"T7142"},{"id":"R4718","pred":"compound","subj":"T7152","obj":"T7153"},{"id":"R4719","pred":"pobj","subj":"T7153","obj":"T7151"},{"id":"R4721","pred":"punct","subj":"T7154","obj":"T7142"},{"id":"R4722","pred":"det","subj":"T7156","obj":"T7157"},{"id":"R4723","pred":"nsubj","subj":"T7157","obj":"T7162"},{"id":"R4724","pred":"amod","subj":"T7158","obj":"T7157"},{"id":"R4726","pred":"amod","subj":"T7159","obj":"T7157"},{"id":"R4727","pred":"cc","subj":"T7160","obj":"T7159"},{"id":"R4728","pred":"conj","subj":"T7161","obj":"T7159"},{"id":"R4729","pred":"prep","subj":"T7163","obj":"T7157"},{"id":"R4730","pred":"det","subj":"T7164","obj":"T7165"},{"id":"R4732","pred":"pobj","subj":"T7165","obj":"T7163"},{"id":"R4733","pred":"compound","subj":"T7166","obj":"T7165"},{"id":"R4734","pred":"prep","subj":"T7167","obj":"T7157"},{"id":"R4735","pred":"det","subj":"T7168","obj":"T7169"},{"id":"R4737","pred":"pobj","subj":"T7169","obj":"T7167"},{"id":"R4738","pred":"amod","subj":"T7170","obj":"T7169"},{"id":"R4739","pred":"aux","subj":"T7171","obj":"T7162"},{"id":"R4741","pred":"neg","subj":"T7172","obj":"T7162"},{"id":"R4742","pred":"advmod","subj":"T7173","obj":"T7162"},{"id":"R4743","pred":"det","subj":"T7174","obj":"T7175"},{"id":"R4745","pred":"attr","subj":"T7175","obj":"T7162"},{"id":"R4746","pred":"prep","subj":"T7176","obj":"T7175"},{"id":"R4748","pred":"det","subj":"T7177","obj":"T7178"},{"id":"R4749","pred":"pobj","subj":"T7178","obj":"T7176"},{"id":"R4750","pred":"compound","subj":"T7179","obj":"T7178"},{"id":"R4753","pred":"punct","subj":"T7180","obj":"T7162"},{"id":"R4754","pred":"cc","subj":"T7181","obj":"T7162"},{"id":"R4756","pred":"advmod","subj":"T7182","obj":"T7183"},{"id":"R4757","pred":"conj","subj":"T7183","obj":"T7162"},{"id":"R4758","pred":"aux","subj":"T7184","obj":"T7183"},{"id":"R4760","pred":"det","subj":"T7185","obj":"T7186"},{"id":"R4761","pred":"dobj","subj":"T7186","obj":"T7183"},{"id":"R4763","pred":"amod","subj":"T7187","obj":"T7186"},{"id":"R4764","pred":"punct","subj":"T7188","obj":"T7187"},{"id":"R4765","pred":"cc","subj":"T7189","obj":"T7187"},{"id":"R4767","pred":"neg","subj":"T7190","obj":"T7189"},{"id":"R4768","pred":"conj","subj":"T7191","obj":"T7187"},{"id":"R4772","pred":"punct","subj":"T7192","obj":"T7186"},{"id":"R4774","pred":"prep","subj":"T7193","obj":"T7186"},{"id":"R4775","pred":"det","subj":"T7194","obj":"T7195"},{"id":"R4776","pred":"pobj","subj":"T7195","obj":"T7193"},{"id":"R4778","pred":"compound","subj":"T7196","obj":"T7195"},{"id":"R4779","pred":"appos","subj":"T7197","obj":"T7195"},{"id":"R4780","pred":"punct","subj":"T7198","obj":"T7162"},{"id":"R4781","pred":"det","subj":"T7200","obj":"T7201"},{"id":"R4782","pred":"nsubj","subj":"T7201","obj":"T7202"},{"id":"R4784","pred":"prep","subj":"T7203","obj":"T7201"},{"id":"R4785","pred":"det","subj":"T7204","obj":"T7205"},{"id":"R4787","pred":"pobj","subj":"T7205","obj":"T7203"},{"id":"R4788","pred":"amod","subj":"T7206","obj":"T7205"},{"id":"R4790","pred":"det","subj":"T7207","obj":"T7208"},{"id":"R4791","pred":"dobj","subj":"T7208","obj":"T7202"},{"id":"R4792","pred":"punct","subj":"T7209","obj":"T7202"},{"id":"R4905","pred":"det","subj":"T7071","obj":"T7072"},{"id":"R4906","pred":"nsubj","subj":"T7072","obj":"T7075"},{"id":"R4907","pred":"amod","subj":"T7073","obj":"T7072"},{"id":"R4911","pred":"amod","subj":"T7074","obj":"T7072"},{"id":"R4913","pred":"prep","subj":"T7076","obj":"T7072"},{"id":"R4918","pred":"det","subj":"T7077","obj":"T7078"},{"id":"R4922","pred":"poss","subj":"T7078","obj":"T7081"},{"id":"R4925","pred":"nmod","subj":"T7079","obj":"T7078"},{"id":"R4929","pred":"amod","subj":"T7080","obj":"T7078"},{"id":"R4933","pred":"pobj","subj":"T7081","obj":"T7076"},{"id":"R4936","pred":"case","subj":"T7082","obj":"T7078"},{"id":"R4943","pred":"det","subj":"T7083","obj":"T7084"},{"id":"R4948","pred":"attr","subj":"T7084","obj":"T7075"}],"text":"The final biological event in a lens epithelial cell's life is the transformation from an epithelial cell into a fiber cell, which occurs at the equatorial/bow region of the lens. The newly forming fiber cell continues to differentiate in the cortex until a mature fiber cell devoid of organelles with suture formation at the ends of the cell is formed. This entire process from epithelial cell to mature fiber cell is defined as lens differentiation. The precise spatial and temporal expression of the crystallin proteins in the developing lens may not be simply a consequence of the differentiation process, but instead may play an important, if not essential, role in the differentiation process itself. The results of the current study support this hypothesis."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T5793","span":{"begin":379,"end":389},"obj":"UBERON:0000483"},{"id":"T5792","span":{"begin":338,"end":342},"obj":"CL_GO_EXT:cell"},{"id":"T5791","span":{"begin":302,"end":308},"obj":"UBERON:4200215"},{"id":"T5790","span":{"begin":286,"end":296},"obj":"GO:0043226"},{"id":"T5789","span":{"begin":271,"end":275},"obj":"CL_GO_EXT:cell"},{"id":"T5788","span":{"begin":243,"end":249},"obj":"UBERON:0001851"},{"id":"T5787","span":{"begin":222,"end":235},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T5786","span":{"begin":204,"end":208},"obj":"CL_GO_EXT:cell"},{"id":"T5785","span":{"begin":174,"end":178},"obj":"UBERON_EXT:lens"},{"id":"T5784","span":{"begin":119,"end":123},"obj":"CL_GO_EXT:cell"},{"id":"T5783","span":{"begin":101,"end":105},"obj":"CL_GO_EXT:cell"},{"id":"T5782","span":{"begin":90,"end":105},"obj":"CL:0000066"},{"id":"T5781","span":{"begin":90,"end":100},"obj":"UBERON:0000483"},{"id":"T5780","span":{"begin":48,"end":52},"obj":"CL_GO_EXT:cell"},{"id":"T5779","span":{"begin":32,"end":52},"obj":"CL:0002224"},{"id":"T5778","span":{"begin":32,"end":47},"obj":"UBERON:0001803"},{"id":"T5777","span":{"begin":10,"end":26},"obj":"GO:0008150"},{"id":"T5776","span":{"begin":10,"end":20},"obj":"CHEBI_GO_EXT:biological_process_or_quality_or_role"},{"id":"T5794","span":{"begin":379,"end":394},"obj":"CL:0000066"},{"id":"T5795","span":{"begin":390,"end":394},"obj":"CL_GO_EXT:cell"},{"id":"T5803","span":{"begin":675,"end":690},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T5802","span":{"begin":585,"end":600},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T5801","span":{"begin":541,"end":545},"obj":"UBERON_EXT:lens"},{"id":"T5800","span":{"begin":514,"end":522},"obj":"CHEBI_PR_EXT:protein"},{"id":"T5799","span":{"begin":485,"end":495},"obj":"GO:0010467"},{"id":"T5798","span":{"begin":435,"end":450},"obj":"GO_RO_EXT:developmental_differentiation_process"},{"id":"T5797","span":{"begin":430,"end":434},"obj":"UBERON_EXT:lens"},{"id":"T5796","span":{"begin":411,"end":415},"obj":"CL_GO_EXT:cell"}],"text":"The final biological event in a lens epithelial cell's life is the transformation from an epithelial cell into a fiber cell, which occurs at the equatorial/bow region of the lens. The newly forming fiber cell continues to differentiate in the cortex until a mature fiber cell devoid of organelles with suture formation at the ends of the cell is formed. This entire process from epithelial cell to mature fiber cell is defined as lens differentiation. The precise spatial and temporal expression of the crystallin proteins in the developing lens may not be simply a consequence of the differentiation process, but instead may play an important, if not essential, role in the differentiation process itself. The results of the current study support this hypothesis."}