PMC:149350 / 20448-22299 JSONTXT

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In contrast, radial columns of elongated fiber cells of uniform size and shape, with ball and socket interdigitations, were present in the anterior cortical region of 5 wk (Figure 4H), 46 wk (Figure 4K) and 72 week (data not shown) wild type lenses. The posterior subcapsular regions of 5 wk (Figure 4C) and 54 wk (Figure 4F) alphaA/BKO lenses were filled with irregularly shaped cells with numerous cell surface projections. In the fetal/embryonic nucleus, elongated fiber cells with numerous long, finger-like projections and furrowed membranes were evident (not shown). No elongated cells extending from the bow region to the posterior capsule of alphaA/BKO lenses were observed. In contrast, radial columns of elongated fiber cells of uniform size and shape containing ball and socket interdigitations were observed in the posterior subcapsular region in 5 wk (Figure 4I), 46 wk (Figure 4L) and 72 wk (data not shown) wild type lenses, and fiber cells in contact with the posterior capsule could be traced back to the equatorial bow region and anterior 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