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of mid-axial sections stained with DiI and SYTOX green revealed unique differences in gross morphology and nucleic acid staining between alphaA/BKO lenses and wild type lenses (Figure 2). In five week old alphaA/BKO lenses, Sytox green stained nuclei (green) in the anterior epithelium, equatorial/bow, and posterior subcapsular regions (Figure 2A). Cell nuclei localized to the equatorial/bow region were disorganized as compared to wild type. There were enlarged extracellular spaces between cells in the equatorial/bow region in 5 wk old alphaA/BKO lenses. Fifty-four wk old alphaA/BKO lenses (Figure 2B) did not stain for nucleic acid in the posterior subcapsular region, however, the entire anterior subcapsular lens region stained for nucleic acid (refer to Figure 3I for high magnification/resolution image of this area). A defined equatorial/bow region was not observed in these older lenses, and fiber cells extending to the posterior capsule of the lens were not found. Disorganized cellular material capped the anterior region of the embryonic/fetal nucleus, and a distinctive indentation of the lens mass at the equatorial region was apparent in mid-axial sections as well as whole lenses. In alphaA/BKO lenses the embryonic/fetal nucleus (primary lens fibers) had migrated posteriorly and appeared to be in contact with the posterior capsule. In 5 wk, 46 wk or 72 wk old wild type lenses (Figure 2C,2D and 2E), however, there was no posterior or anterior subcapsular nucleic acid staining and the embryonic-fetal nucleus was centrally located, not in contact with the posterior capsule."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T3131","span":{"begin":1603,"end":1610},"obj":"UBERON:0003893"},{"id":"T3130","span":{"begin":1538,"end":1545},"obj":"UBERON:0000390"},{"id":"T3129","span":{"begin":1522,"end":1531},"obj":"UBERON:0000922"},{"id":"T3128","span":{"begin":1492,"end":1504},"obj":"CHEBI_SO_EXT:nucleic_acid"},{"id":"T3127","span":{"begin":1492,"end":1499},"obj":"GO:0005634"},{"id":"T3126","span":{"begin":1483,"end":1491},"obj":"UBERON:0003893"},{"id":"T3125","span":{"begin":1406,"end":1412},"obj":"UBERON_EXT:lens"},{"id":"T3124","span":{"begin":1396,"end":1405},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T3123","span":{"begin":1359,"end":1366},"obj":"UBERON:0003893"},{"id":"T3122","span":{"begin":1289,"end":1297},"obj":"GO_EXT:biological_movement_or_translocation_process"},{"id":"T3121","span":{"begin":1272,"end":1283},"obj":"CL_UBERON_EXT:lens_fiber"},{"id":"T3120","span":{"begin":1264,"end":1283},"obj":"CL:0002228"},{"id":"T3119","span":{"begin":1255,"end":1262},"obj":"UBERON:0000390"},{"id":"T3118","span":{"begin":1239,"end":1248},"obj":"UBERON:0000922"},{"id":"T3117","span":{"begin":1228,"end":1234},"obj":"UBERON_EXT:lens"},{"id":"T3116","span":{"begin":1217,"end":1223},"obj":"PR_EXT:000005907"},{"id":"T3115","span":{"begin":1206,"end":1212},"obj":"UBERON_EXT:lens"},{"id":"T3114","span":{"begin":1119,"end":1123},"obj":"UBERON_EXT:lens"},{"id":"T3113","span":{"begin":1073,"end":1080},"obj":"UBERON:0000390"},{"id":"T3112","span":{"begin":1057,"end":1066},"obj":"UBERON:0000922"},{"id":"T3111","span":{"begin":1005,"end":1013},"obj":"CL_GO_EXT:cell"},{"id":"T3110","span":{"begin":971,"end":975},"obj":"UBERON:0001804"},{"id":"T3109","span":{"begin":956,"end":966},"obj":"_FRAGMENT"},{"id":"T3108","span":{"begin":923,"end":928},"obj":"CL_GO_EXT:cell"},{"id":"T3107","span":{"begin":905,"end":911},"obj":"UBERON_EXT:lens"},{"id":"T3106","span":{"begin":753,"end":765},"obj":"CHEBI_SO_EXT:nucleic_acid"},{"id":"T3105","span":{"begin":753,"end":760},"obj":"GO:0005634"},{"id":"T3104","span":{"begin":729,"end":733},"obj":"UBERON_EXT:lens"},{"id":"T3103","span":{"begin":720,"end":728},"obj":"UBERON:0003893"},{"id":"T3102","span":{"begin":671,"end":679},"obj":"UBERON:0003893"},{"id":"T3101","span":{"begin":638,"end":650},"obj":"CHEBI_SO_EXT:nucleic_acid"},{"id":"T3100","span":{"begin":638,"end":645},"obj":"GO:0005634"},{"id":"T3099","span":{"begin":601,"end":607},"obj":"UBERON_EXT:lens"},{"id":"T3098","span":{"begin":590,"end":596},"obj":"PR_EXT:000005907"},{"id":"T3097","span":{"begin":564,"end":570},"obj":"UBERON_EXT:lens"},{"id":"T3096","span":{"begin":553,"end":559},"obj":"PR_EXT:000005907"},{"id":"T3095","span":{"begin":506,"end":511},"obj":"CL_GO_EXT:cell"},{"id":"T3094","span":{"begin":482,"end":490},"obj":"CL_GO_EXT:cell"},{"id":"T3093","span":{"begin":477,"end":497},"obj":"GO:0005615"},{"id":"T3092","span":{"begin":446,"end":455},"obj":"SO_EXT:wild_type_entity"},{"id":"T3091","span":{"begin":374,"end":383},"obj":"GO_PATO_EXT:biological_localization_process_or_quality"},{"id":"T3090","span":{"begin":362,"end":373},"obj":"GO:0005634"},{"id":"T3089","span":{"begin":362,"end":366},"obj":"CL_GO_EXT:cell"},{"id":"T3088","span":{"begin":332,"end":340},"obj":"UBERON:0003893"},{"id":"T3087","span":{"begin":287,"end":297},"obj":"UBERON:0000483"},{"id":"T3086","span":{"begin":256,"end":262},"obj":"GO:0005634"},{"id":"T3085","span":{"begin":228,"end":234},"obj":"UBERON_EXT:lens"},{"id":"T3084","span":{"begin":217,"end":223},"obj":"PR_EXT:000005907"},{"id":"T3083","span":{"begin":181,"end":187},"obj":"UBERON_EXT:lens"},{"id":"T3082","span":{"begin":171,"end":180},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T3081","span":{"begin":160,"end":166},"obj":"UBERON_EXT:lens"},{"id":"T3080","span":{"begin":149,"end":155},"obj":"PR_EXT:000005907"},{"id":"T3079","span":{"begin":119,"end":131},"obj":"CHEBI_SO_EXT:nucleic_acid"},{"id":"T3078","span":{"begin":119,"end":126},"obj":"GO:0005634"},{"id":"T3077","span":{"begin":47,"end":50},"obj":"CHEBI:52029"}],"relations":[{"id":"R1974","pred":"_lexicallyChainedTo","subj":"T3110","obj":"T3109"}],"text":"Examination of mid-axial sections stained with DiI and SYTOX green revealed unique differences in gross morphology and nucleic acid staining between alphaA/BKO lenses and wild type lenses (Figure 2). In five week old alphaA/BKO lenses, Sytox green stained nuclei (green) in the anterior epithelium, equatorial/bow, and posterior subcapsular regions (Figure 2A). Cell nuclei localized to the equatorial/bow region were disorganized as compared to wild type. There were enlarged extracellular spaces between cells in the equatorial/bow region in 5 wk old alphaA/BKO lenses. Fifty-four wk old alphaA/BKO lenses (Figure 2B) did not stain for nucleic acid in the posterior subcapsular region, however, the entire anterior subcapsular lens region stained for nucleic acid (refer to Figure 3I for high magnification/resolution image of this area). A defined equatorial/bow region was not observed in these older lenses, and fiber cells extending to the posterior capsule of the lens were not found. Disorganized cellular material capped the anterior region of the embryonic/fetal nucleus, and a distinctive indentation of the lens mass at the equatorial region was apparent in mid-axial sections as well as whole lenses. In alphaA/BKO lenses the embryonic/fetal nucleus (primary lens fibers) had migrated posteriorly and appeared to be in contact with the posterior capsule. In 5 wk, 46 wk or 72 wk old wild type lenses (Figure 2C,2D and 2E), however, there was no posterior or anterior subcapsular nucleic acid staining and the embryonic-fetal nucleus was centrally located, not in contact with the posterior capsule."}