PMC:1482699 / 3570-3961 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1482699","sourcedb":"PMC","sourceid":"1482699","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1482699","text":"The C57Bl/6J-hg/hg (HG) mouse is a model of systemic overgrowth resulting from a spontaneous deletion on MMU10, which eliminates expression of the Socs2 (suppressor of cytokine signaling 2) gene [14-16]. The role of Socs2 in the HG phenotype was confirmed by an independently engineered Socs2-/- knockout mouse which shared a number of phenotypes in common with HG, including gigantism [17].","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T3067","span":{"begin":0,"end":3},"obj":"DT"},{"id":"T3068","span":{"begin":24,"end":29},"obj":"NN"},{"id":"T3069","span":{"begin":4,"end":9},"obj":"NN"},{"id":"T3070","span":{"begin":16,"end":18},"obj":"NN"},{"id":"T3071","span":{"begin":9,"end":10},"obj":"HYPH"},{"id":"T3072","span":{"begin":10,"end":12},"obj":"NN"},{"id":"T3073","span":{"begin":12,"end":13},"obj":"HYPH"},{"id":"T3074","span":{"begin":13,"end":15},"obj":"NN"},{"id":"T3075","span":{"begin":15,"end":16},"obj":"HYPH"},{"id":"T3076","span":{"begin":19,"end":20},"obj":"-LRB-"},{"id":"T3077","span":{"begin":20,"end":22},"obj":"NN"},{"id":"T3078","span":{"begin":22,"end":23},"obj":"-RRB-"},{"id":"T3079","span":{"begin":30,"end":32},"obj":"VBZ"},{"id":"T3080","span":{"begin":33,"end":34},"obj":"DT"},{"id":"T3081","span":{"begin":35,"end":40},"obj":"NN"},{"id":"T3082","span":{"begin":41,"end":43},"obj":"IN"},{"id":"T3083","span":{"begin":44,"end":52},"obj":"JJ"},{"id":"T3084","span":{"begin":53,"end":63},"obj":"NN"},{"id":"T3085","span":{"begin":64,"end":73},"obj":"VBG"},{"id":"T3086","span":{"begin":74,"end":78},"obj":"IN"},{"id":"T3087","span":{"begin":79,"end":80},"obj":"DT"},{"id":"T3088","span":{"begin":93,"end":101},"obj":"NN"},{"id":"T3089","span":{"begin":81,"end":92},"obj":"JJ"},{"id":"T3090","span":{"begin":102,"end":104},"obj":"IN"},{"id":"T3091","span":{"begin":105,"end":110},"obj":"NN"},{"id":"T3092","span":{"begin":110,"end":112},"obj":","},{"id":"T3093","span":{"begin":112,"end":117},"obj":"WDT"},{"id":"T3094","span":{"begin":118,"end":128},"obj":"VBZ"},{"id":"T3095","span":{"begin":129,"end":139},"obj":"NN"},{"id":"T3096","span":{"begin":140,"end":142},"obj":"IN"},{"id":"T3097","span":{"begin":143,"end":146},"obj":"DT"},{"id":"T3098","span":{"begin":190,"end":194},"obj":"NN"},{"id":"T3099","span":{"begin":147,"end":152},"obj":"NN"},{"id":"T3100","span":{"begin":153,"end":154},"obj":"-LRB-"},{"id":"T3101","span":{"begin":154,"end":164},"obj":"NN"},{"id":"T3102","span":{"begin":165,"end":167},"obj":"IN"},{"id":"T3103","span":{"begin":168,"end":176},"obj":"NN"},{"id":"T3104","span":{"begin":177,"end":186},"obj":"NN"},{"id":"T3105","span":{"begin":187,"end":188},"obj":"CD"},{"id":"T3106","span":{"begin":188,"end":189},"obj":"-RRB-"},{"id":"T3107","span":{"begin":195,"end":196},"obj":"-LRB-"},{"id":"T3108","span":{"begin":196,"end":198},"obj":"CD"},{"id":"T3109","span":{"begin":198,"end":199},"obj":"SYM"},{"id":"T3110","span":{"begin":199,"end":201},"obj":"CD"},{"id":"T3111","span":{"begin":201,"end":202},"obj":"-RRB-"},{"id":"T3112","span":{"begin":202,"end":203},"obj":"."},{"id":"T3113","span":{"begin":203,"end":391},"obj":"sentence"},{"id":"T3114","span":{"begin":204,"end":207},"obj":"DT"},{"id":"T3115","span":{"begin":208,"end":212},"obj":"NN"},{"id":"T3116","span":{"begin":246,"end":255},"obj":"VBN"},{"id":"T3117","span":{"begin":213,"end":215},"obj":"IN"},{"id":"T3118","span":{"begin":216,"end":221},"obj":"NN"},{"id":"T3119","span":{"begin":222,"end":224},"obj":"IN"},{"id":"T3120","span":{"begin":225,"end":228},"obj":"DT"},{"id":"T3121","span":{"begin":232,"end":241},"obj":"NN"},{"id":"T3122","span":{"begin":229,"end":231},"obj":"NN"},{"id":"T3123","span":{"begin":242,"end":245},"obj":"VBD"},{"id":"T3124","span":{"begin":256,"end":258},"obj":"IN"},{"id":"T3125","span":{"begin":259,"end":261},"obj":"DT"},{"id":"T3126","span":{"begin":305,"end":310},"obj":"NN"},{"id":"T3127","span":{"begin":262,"end":275},"obj":"RB"},{"id":"T3128","span":{"begin":276,"end":286},"obj":"VBN"},{"id":"T3129","span":{"begin":287,"end":292},"obj":"NN"},{"id":"T3130","span":{"begin":296,"end":304},"obj":"NN"},{"id":"T3131","span":{"begin":292,"end":293},"obj":"SYM"},{"id":"T3132","span":{"begin":293,"end":294},"obj":"HYPH"},{"id":"T3133","span":{"begin":294,"end":295},"obj":"SYM"},{"id":"T3134","span":{"begin":311,"end":316},"obj":"WDT"},{"id":"T3135","span":{"begin":317,"end":323},"obj":"VBD"},{"id":"T3136","span":{"begin":324,"end":325},"obj":"DT"},{"id":"T3137","span":{"begin":326,"end":332},"obj":"NN"},{"id":"T3138","span":{"begin":333,"end":335},"obj":"IN"},{"id":"T3139","span":{"begin":336,"end":346},"obj":"NNS"},{"id":"T3140","span":{"begin":347,"end":349},"obj":"IN"},{"id":"T3141","span":{"begin":350,"end":356},"obj":"NN"},{"id":"T3142","span":{"begin":357,"end":361},"obj":"IN"},{"id":"T3143","span":{"begin":362,"end":364},"obj":"NN"},{"id":"T3144","span":{"begin":364,"end":366},"obj":","},{"id":"T3145","span":{"begin":366,"end":375},"obj":"VBG"},{"id":"T3146","span":{"begin":376,"end":385},"obj":"NN"},{"id":"T3147","span":{"begin":386,"end":387},"obj":"-LRB-"},{"id":"T3148","span":{"begin":387,"end":389},"obj":"CD"},{"id":"T3149","span":{"begin":389,"end":390},"obj":"-RRB-"},{"id":"T3150","span":{"begin":390,"end":391},"obj":"."}],"relations":[{"id":"R595","pred":"det","subj":"T3114","obj":"T3115"},{"id":"R600","pred":"nsubjpass","subj":"T3115","obj":"T3116"},{"id":"R604","pred":"prep","subj":"T3117","obj":"T3115"},{"id":"R608","pred":"det","subj":"T3067","obj":"T3068"},{"id":"R609","pred":"pobj","subj":"T3118","obj":"T3117"},{"id":"R610","pred":"nsubj","subj":"T3068","obj":"T3079"},{"id":"R611","pred":"nmod","subj":"T3069","obj":"T3070"},{"id":"R613","pred":"prep","subj":"T3119","obj":"T3115"},{"id":"R614","pred":"punct","subj":"T3071","obj":"T3070"},{"id":"R615","pred":"nmod","subj":"T3072","obj":"T3070"},{"id":"R616","pred":"punct","subj":"T3073","obj":"T3070"},{"id":"R617","pred":"nmod","subj":"T3074","obj":"T3070"},{"id":"R618","pred":"det","subj":"T3120","obj":"T3121"},{"id":"R619","pred":"punct","subj":"T3075","obj":"T3070"},{"id":"R620","pred":"punct","subj":"T3076","obj":"T3077"},{"id":"R621","pred":"parataxis","subj":"T3077","obj":"T3070"},{"id":"R622","pred":"pobj","subj":"T3121","obj":"T3119"},{"id":"R623","pred":"punct","subj":"T3078","obj":"T3077"},{"id":"R624","pred":"det","subj":"T3080","obj":"T3081"},{"id":"R625","pred":"compound","subj":"T3122","obj":"T3121"},{"id":"R626","pred":"attr","subj":"T3081","obj":"T3079"},{"id":"R627","pred":"prep","subj":"T3082","obj":"T3081"},{"id":"R628","pred":"amod","subj":"T3083","obj":"T3084"},{"id":"R629","pred":"auxpass","subj":"T3123","obj":"T3116"},{"id":"R630","pred":"pobj","subj":"T3084","obj":"T3082"},{"id":"R631","pred":"acl","subj":"T3085","obj":"T3081"},{"id":"R632","pred":"agent","subj":"T3124","obj":"T3116"},{"id":"R633","pred":"prep","subj":"T3086","obj":"T3085"},{"id":"R634","pred":"det","subj":"T3087","obj":"T3088"},{"id":"R635","pred":"pobj","subj":"T3088","obj":"T3086"},{"id":"R636","pred":"det","subj":"T3125","obj":"T3126"},{"id":"R637","pred":"amod","subj":"T3089","obj":"T3088"},{"id":"R638","pred":"prep","subj":"T3090","obj":"T3088"},{"id":"R639","pred":"pobj","subj":"T3091","obj":"T3090"},{"id":"R640","pred":"pobj","subj":"T3126","obj":"T3124"},{"id":"R641","pred":"punct","subj":"T3092","obj":"T3091"},{"id":"R642","pred":"dep","subj":"T3093","obj":"T3094"},{"id":"R643","pred":"relcl","subj":"T3094","obj":"T3091"},{"id":"R644","pred":"dobj","subj":"T3095","obj":"T3094"},{"id":"R645","pred":"prep","subj":"T3096","obj":"T3095"},{"id":"R646","pred":"det","subj":"T3097","obj":"T3098"},{"id":"R647","pred":"advmod","subj":"T3127","obj":"T3128"},{"id":"R648","pred":"pobj","subj":"T3098","obj":"T3096"},{"id":"R649","pred":"nmod","subj":"T3099","obj":"T3098"},{"id":"R650","pred":"punct","subj":"T3100","obj":"T3099"},{"id":"R651","pred":"appos","subj":"T3101","obj":"T3099"},{"id":"R652","pred":"amod","subj":"T3128","obj":"T3126"},{"id":"R653","pred":"prep","subj":"T3102","obj":"T3101"},{"id":"R654","pred":"compound","subj":"T3103","obj":"T3104"},{"id":"R655","pred":"pobj","subj":"T3104","obj":"T3102"},{"id":"R656","pred":"nmod","subj":"T3129","obj":"T3130"},{"id":"R657","pred":"nummod","subj":"T3105","obj":"T3104"},{"id":"R658","pred":"punct","subj":"T3106","obj":"T3098"},{"id":"R659","pred":"punct","subj":"T3107","obj":"T3108"},{"id":"R660","pred":"compound","subj":"T3130","obj":"T3126"},{"id":"R661","pred":"punct","subj":"T3131","obj":"T3129"},{"id":"R662","pred":"parataxis","subj":"T3108","obj":"T3079"},{"id":"R663","pred":"punct","subj":"T3109","obj":"T3110"},{"id":"R664","pred":"punct","subj":"T3132","obj":"T3129"},{"id":"R665","pred":"punct","subj":"T3133","obj":"T3129"},{"id":"R666","pred":"prep","subj":"T3110","obj":"T3108"},{"id":"R667","pred":"dep","subj":"T3134","obj":"T3135"},{"id":"R668","pred":"punct","subj":"T3111","obj":"T3108"},{"id":"R669","pred":"punct","subj":"T3112","obj":"T3079"},{"id":"R676","pred":"pobj","subj":"T3139","obj":"T3138"},{"id":"R680","pred":"prep","subj":"T3140","obj":"T3137"},{"id":"R683","pred":"pobj","subj":"T3141","obj":"T3140"},{"id":"R688","pred":"prep","subj":"T3142","obj":"T3141"},{"id":"R691","pred":"pobj","subj":"T3143","obj":"T3142"},{"id":"R694","pred":"punct","subj":"T3144","obj":"T3137"},{"id":"R702","pred":"prep","subj":"T3145","obj":"T3137"},{"id":"R706","pred":"pobj","subj":"T3146","obj":"T3145"},{"id":"R709","pred":"punct","subj":"T3147","obj":"T3148"},{"id":"R711","pred":"parataxis","subj":"T3148","obj":"T3116"},{"id":"R715","pred":"punct","subj":"T3149","obj":"T3148"},{"id":"R719","pred":"punct","subj":"T3150","obj":"T3116"},{"id":"R612","pred":"nmod","subj":"T3070","obj":"T3068"},{"id":"R670","pred":"relcl","subj":"T3135","obj":"T3126"},{"id":"R671","pred":"det","subj":"T3136","obj":"T3137"},{"id":"R672","pred":"dobj","subj":"T3137","obj":"T3135"},{"id":"R673","pred":"prep","subj":"T3138","obj":"T3137"}],"attributes":[{"subj":"T3067","pred":"source","obj":"craft-sa-dev"},{"subj":"T3068","pred":"source","obj":"craft-sa-dev"},{"subj":"T3069","pred":"source","obj":"craft-sa-dev"},{"subj":"T3070","pred":"source","obj":"craft-sa-dev"},{"subj":"T3071","pred":"source","obj":"craft-sa-dev"},{"subj":"T3072","pred":"source","obj":"craft-sa-dev"},{"subj":"T3073","pred":"source","obj":"craft-sa-dev"},{"subj":"T3074","pred":"source","obj":"craft-sa-dev"},{"subj":"T3075","pred":"source","obj":"craft-sa-dev"},{"subj":"T3076","pred":"source","obj":"craft-sa-dev"},{"subj":"T3077","pred":"source","obj":"craft-sa-dev"},{"subj":"T3078","pred":"source","obj":"craft-sa-dev"},{"subj":"T3079","pred":"source","obj":"craft-sa-dev"},{"subj":"T3080","pred":"source","obj":"craft-sa-dev"},{"subj":"T3081","pred":"source","obj":"craft-sa-dev"},{"subj":"T3082","pred":"source","obj":"craft-sa-dev"},{"subj":"T3083","pred":"source","obj":"craft-sa-dev"},{"subj":"T3084","pred":"source","obj":"craft-sa-dev"},{"subj":"T3085","pred":"source","obj":"craft-sa-dev"},{"subj":"T3086","pred":"source","obj":"craft-sa-dev"},{"subj":"T3087","pred":"source","obj":"craft-sa-dev"},{"subj":"T3088","pred":"source","obj":"craft-sa-dev"},{"subj":"T3089","pred":"source","obj":"craft-sa-dev"},{"subj":"T3090","pred":"source","obj":"craft-sa-dev"},{"subj":"T3091","pred":"source","obj":"craft-sa-dev"},{"subj":"T3092","pred":"source","obj":"craft-sa-dev"},{"subj":"T3093","pred":"source","obj":"craft-sa-dev"},{"subj":"T3094","pred":"source","obj":"craft-sa-dev"},{"subj":"T3095","pred":"source","obj":"craft-sa-dev"},{"subj":"T3096","pred":"source","obj":"craft-sa-dev"},{"subj":"T3097","pred":"source","obj":"craft-sa-dev"},{"subj":"T3098","pred":"source","obj":"craft-sa-dev"},{"subj":"T3099","pred":"source","obj":"craft-sa-dev"},{"subj":"T3100","pred":"source","obj":"craft-sa-dev"},{"subj":"T3101","pred":"source","obj":"craft-sa-dev"},{"subj":"T3102","pred":"source","obj":"craft-sa-dev"},{"subj":"T3103","pred":"source","obj":"craft-sa-dev"},{"subj":"T3104","pred":"source","obj":"craft-sa-dev"},{"subj":"T3105","pred":"source","obj":"craft-sa-dev"},{"subj":"T3106","pred":"source","obj":"craft-sa-dev"},{"subj":"T3107","pred":"source","obj":"craft-sa-dev"},{"subj":"T3108","pred":"source","obj":"craft-sa-dev"},{"subj":"T3109","pred":"source","obj":"craft-sa-dev"},{"subj":"T3110","pred":"source","obj":"craft-sa-dev"},{"subj":"T3111","pred":"source","obj":"craft-sa-dev"},{"subj":"T3112","pred":"source","obj":"craft-sa-dev"},{"subj":"T3113","pred":"source","obj":"craft-sa-dev"},{"subj":"T3114","pred":"source","obj":"craft-sa-dev"},{"subj":"T3115","pred":"source","obj":"craft-sa-dev"},{"subj":"T3116","pred":"source","obj":"craft-sa-dev"},{"subj":"T3117","pred":"source","obj":"craft-sa-dev"},{"subj":"T3118","pred":"source","obj":"craft-sa-dev"},{"subj":"T3119","pred":"source","obj":"craft-sa-dev"},{"subj":"T3120","pred":"source","obj":"craft-sa-dev"},{"subj":"T3121","pred":"source","obj":"craft-sa-dev"},{"subj":"T3122","pred":"source","obj":"craft-sa-dev"},{"subj":"T3123","pred":"source","obj":"craft-sa-dev"},{"subj":"T3124","pred":"source","obj":"craft-sa-dev"},{"subj":"T3125","pred":"source","obj":"craft-sa-dev"},{"subj":"T3126","pred":"source","obj":"craft-sa-dev"},{"subj":"T3127","pred":"source","obj":"craft-sa-dev"},{"subj":"T3128","pred":"source","obj":"craft-sa-dev"},{"subj":"T3129","pred":"source","obj":"craft-sa-dev"},{"subj":"T3130","pred":"source","obj":"craft-sa-dev"},{"subj":"T3131","pred":"source","obj":"craft-sa-dev"},{"subj":"T3132","pred":"source","obj":"craft-sa-dev"},{"subj":"T3133","pred":"source","obj":"craft-sa-dev"},{"subj":"T3134","pred":"source","obj":"craft-sa-dev"},{"subj":"T3135","pred":"source","obj":"craft-sa-dev"},{"subj":"T3136","pred":"source","obj":"craft-sa-dev"},{"subj":"T3137","pred":"source","obj":"craft-sa-dev"},{"subj":"T3138","pred":"source","obj":"craft-sa-dev"},{"subj":"T3139","pred":"source","obj":"craft-sa-dev"},{"subj":"T3140","pred":"source","obj":"craft-sa-dev"},{"subj":"T3141","pred":"source","obj":"craft-sa-dev"},{"subj":"T3142","pred":"source","obj":"craft-sa-dev"},{"subj":"T3143","pred":"source","obj":"craft-sa-dev"},{"subj":"T3144","pred":"source","obj":"craft-sa-dev"},{"subj":"T3145","pred":"source","obj":"craft-sa-dev"},{"subj":"T3146","pred":"source","obj":"craft-sa-dev"},{"subj":"T3147","pred":"source","obj":"craft-sa-dev"},{"subj":"T3148","pred":"source","obj":"craft-sa-dev"},{"subj":"T3149","pred":"source","obj":"craft-sa-dev"},{"subj":"T3150","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2656","span":{"begin":24,"end":29},"obj":"NCBITaxon:10088"},{"id":"T2657","span":{"begin":57,"end":63},"obj":"GO_EXT:biological_growth_entity_or_process"},{"id":"T2658","span":{"begin":93,"end":101},"obj":"SO_EXT:sequence_deletion_entity_or_process"},{"id":"T2659","span":{"begin":129,"end":139},"obj":"GO:0010467"},{"id":"T2660","span":{"begin":147,"end":152},"obj":"PR_EXT:000015393"},{"id":"T2661","span":{"begin":154,"end":188},"obj":"PR_EXT:000015393"},{"id":"T2662","span":{"begin":168,"end":176},"obj":"GO_EXT:0005125"},{"id":"T2663","span":{"begin":168,"end":186},"obj":"GO:0019221"},{"id":"T2664","span":{"begin":190,"end":194},"obj":"SO_EXT:0000704"},{"id":"T2665","span":{"begin":216,"end":221},"obj":"PR_EXT:000015393"},{"id":"T2666","span":{"begin":287,"end":292},"obj":"PR_EXT:000015393"},{"id":"T2667","span":{"begin":292,"end":293},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2668","span":{"begin":294,"end":295},"obj":"SO_EXT:sequence_nullness_or_absence"},{"id":"T2669","span":{"begin":305,"end":310},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T2656","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2657","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2658","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2659","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2660","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2661","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2662","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2663","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2664","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2665","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2666","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2667","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2668","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T2669","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T2582","span":{"begin":24,"end":29},"obj":"NCBITaxon:10088"},{"id":"T2583","span":{"begin":129,"end":139},"obj":"GO:0010467"},{"id":"T2584","span":{"begin":147,"end":152},"obj":"PR:000015393"},{"id":"T2585","span":{"begin":154,"end":188},"obj":"PR:000015393"},{"id":"T2586","span":{"begin":168,"end":186},"obj":"GO:0019221"},{"id":"T2587","span":{"begin":190,"end":194},"obj":"SO:0000704"},{"id":"T2588","span":{"begin":216,"end":221},"obj":"PR:000015393"},{"id":"T2589","span":{"begin":287,"end":292},"obj":"PR:000015393"},{"id":"T2590","span":{"begin":305,"end":310},"obj":"NCBITaxon:10088"}],"attributes":[{"subj":"T2582","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2583","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2584","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2585","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2586","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2587","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2588","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2589","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T2590","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ec93d1","default":true},{"id":"craft-ca-core-ex-dev","color":"#93ebec"},{"id":"craft-ca-core-dev","color":"#ecd393"}]}]}}