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Id Subject Object Predicate Lexical cue
T2716 11-14 DT denotes The
T2717 15-18 NN denotes use
T2718 39-47 VBN denotes provided
T2719 19-21 IN denotes of
T2720 22-27 NN denotes mouse
T2721 28-34 NNS denotes models
T2722 35-38 VBZ denotes has
T2723 48-56 JJ denotes valuable
T2724 57-64 NN denotes insight
T2725 65-69 IN denotes into
T2726 70-73 DT denotes the
T2727 74-82 NN denotes etiology
T2728 83-85 IN denotes of
T2729 86-95 JJ denotes monogenic
T2730 96-105 NNS denotes syndromes
T2731 106-112 VBN denotes caused
T2732 113-115 IN denotes by
T2733 116-122 JJ denotes single
T2734 128-137 NNS denotes mutations
T2735 123-127 NN denotes gene
T2736 137-138 . denotes .
T2737 138-252 sentence denotes However, such models do not mimic the genetic complexity of disease traits commonly seen in the human population.
T2738 139-146 RB denotes However
T2739 167-172 VB denotes mimic
T2740 146-148 , denotes ,
T2741 148-152 JJ denotes such
T2742 153-159 NNS denotes models
T2743 160-162 VBP denotes do
T2744 163-166 RB denotes not
T2745 173-176 DT denotes the
T2746 185-195 NN denotes complexity
T2747 177-184 JJ denotes genetic
T2748 196-198 IN denotes of
T2749 199-206 NN denotes disease
T2750 207-213 NNS denotes traits
T2751 214-222 RB denotes commonly
T2752 223-227 VBN denotes seen
T2753 228-230 IN denotes in
T2754 231-234 DT denotes the
T2755 241-251 NN denotes population
T2756 235-240 JJ denotes human
T2757 251-252 . denotes .
T2758 252-487 sentence denotes Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.
T2759 253-260 NN denotes Complex
T2760 261-267 NNS denotes traits
T2761 310-320 VBN denotes influenced
T2762 267-269 , denotes ,
T2763 269-273 JJ denotes such
T2764 274-276 IN denotes as
T2765 277-286 JJ denotes polygenic
T2766 287-293 NN denotes growth
T2767 294-297 CC denotes and
T2768 298-305 NN denotes obesity
T2769 306-309 VBP denotes are
T2770 321-323 IN denotes by
T2771 324-327 DT denotes the
T2772 353-360 NNS denotes effects
T2773 328-333 JJ denotes small
T2774 334-336 IN denotes to
T2775 337-345 JJ denotes moderate
T2776 346-352 JJ denotes direct
T2777 361-363 IN denotes of
T2778 364-376 JJ denotes quantitative
T2779 383-387 NNS denotes loci
T2780 377-382 NN denotes trait
T2781 388-389 -LRB- denotes (
T2782 389-392 NN denotes QTL
T2783 392-393 -RRB- denotes )
T2784 393-395 , denotes ,
T2785 395-404 NN denotes epistasis
T2786 405-412 IN denotes between
T2787 413-416 NN denotes QTL
T2788 417-424 NNS denotes alleles
T2789 424-426 , denotes ,
T2790 426-439 JJ denotes environmental
T2791 440-453 NNS denotes perturbations
T2792 454-457 CC denotes and
T2793 458-461 NN denotes QTL
T2794 462-473 NN denotes environment
T2795 461-462 HYPH denotes -
T2796 474-486 NNS denotes interactions
T2797 486-487 . denotes .
T2798 487-670 sentence denotes To date numerous mouse growth and obesity QTL have been localized [1,2], however, little progress has been made in determining the specific nature of the underlying genetic variants.
T2799 488-490 IN denotes To
T2800 544-553 VBN denotes localized
T2801 491-495 NN denotes date
T2802 496-504 JJ denotes numerous
T2803 530-533 NN denotes QTL
T2804 505-510 NN denotes mouse
T2805 511-517 NN denotes growth
T2806 518-521 CC denotes and
T2807 522-529 NN denotes obesity
T2808 534-538 VBP denotes have
T2809 539-543 VBN denotes been
T2810 595-599 VBN denotes made
T2811 554-555 -LRB- denotes [
T2812 557-558 CD denotes 2
T2813 555-556 CD denotes 1
T2814 556-557 , denotes ,
T2815 558-559 -RRB- denotes ]
T2816 559-561 , denotes ,
T2817 561-568 RB denotes however
T2818 568-570 , denotes ,
T2819 570-576 JJ denotes little
T2820 577-585 NN denotes progress
T2821 586-589 VBZ denotes has
T2822 590-594 VBN denotes been
T2823 600-602 IN denotes in
T2824 603-614 VBG denotes determining
T2825 615-618 DT denotes the
T2826 628-634 NN denotes nature
T2827 619-627 JJ denotes specific
T2828 635-637 IN denotes of
T2829 638-641 DT denotes the
T2830 661-669 NNS denotes variants
T2831 642-652 VBG denotes underlying
T2832 653-660 JJ denotes genetic
T2833 669-670 . denotes .
T2834 670-819 sentence denotes One resource used to fine map QTL are congenic strains which are designed to convert a complex polygenic trait into one that is mono- or oligogenic.
T2835 671-674 CD denotes One
T2836 675-683 NN denotes resource
T2837 705-708 VBP denotes are
T2838 684-688 VBN denotes used
T2839 689-691 TO denotes to
T2840 697-700 VB denotes map
T2841 692-696 RB denotes fine
T2842 701-704 NN denotes QTL
T2843 709-717 JJ denotes congenic
T2844 718-725 NNS denotes strains
T2845 726-731 WDT denotes which
T2846 736-744 VBN denotes designed
T2847 732-735 VBP denotes are
T2848 745-747 TO denotes to
T2849 748-755 VB denotes convert
T2850 756-757 DT denotes a
T2851 776-781 NN denotes trait
T2852 758-765 JJ denotes complex
T2853 766-775 JJ denotes polygenic
T2854 782-786 IN denotes into
T2855 787-790 CD denotes one
T2856 791-795 WDT denotes that
T2857 796-798 VBZ denotes is
T2858 799-803 AFX denotes mono
T2859 808-818 JJ denotes oligogenic
T2860 803-804 HYPH denotes -
T2861 805-807 CC denotes or
T2862 818-819 . denotes .
T2863 819-1039 sentence denotes This is accomplished by eliminating segregating genetic variation outside the locus of interest and reducing the environmental variation influencing a trait by characterizing large numbers of genetically identical mice.
T2864 820-824 DT denotes This
T2865 828-840 VBN denotes accomplished
T2866 825-827 VBZ denotes is
T2867 841-843 IN denotes by
T2868 844-855 VBG denotes eliminating
T2869 856-867 VBG denotes segregating
T2870 868-875 JJ denotes genetic
T2871 876-885 NN denotes variation
T2872 886-893 IN denotes outside
T2873 894-897 DT denotes the
T2874 898-903 NN denotes locus
T2875 904-906 IN denotes of
T2876 907-915 NN denotes interest
T2877 916-919 CC denotes and
T2878 920-928 VBG denotes reducing
T2879 929-932 DT denotes the
T2880 947-956 NN denotes variation
T2881 933-946 JJ denotes environmental
T2882 957-968 VBG denotes influencing
T2883 969-970 DT denotes a
T2884 971-976 NN denotes trait
T2885 977-979 IN denotes by
T2886 980-994 VBG denotes characterizing
T2887 995-1000 JJ denotes large
T2888 1001-1008 NNS denotes numbers
T2889 1009-1011 IN denotes of
T2890 1012-1023 RB denotes genetically
T2891 1024-1033 JJ denotes identical
T2892 1034-1038 NNS denotes mice
T2893 1038-1039 . denotes .
T2894 1039-1168 sentence denotes The Complex Trait Consortium (CTC) considers congenic analysis an excellent method to confirm and subsequently fine map QTL [3].
T2895 1040-1043 DT denotes The
T2896 1058-1068 NNP denotes Consortium
T2897 1044-1051 NNP denotes Complex
T2898 1052-1057 NNP denotes Trait
T2899 1075-1084 VBZ denotes considers
T2900 1069-1070 -LRB- denotes (
T2901 1070-1073 NNP denotes CTC
T2902 1073-1074 -RRB- denotes )
T2903 1085-1093 JJ denotes congenic
T2904 1094-1102 NN denotes analysis
T2905 1116-1122 NN denotes method
T2906 1103-1105 DT denotes an
T2907 1106-1115 JJ denotes excellent
T2908 1123-1125 TO denotes to
T2909 1126-1133 VB denotes confirm
T2910 1134-1137 CC denotes and
T2911 1138-1150 RB denotes subsequently
T2912 1156-1159 VB denotes map
T2913 1151-1155 RB denotes fine
T2914 1160-1163 NN denotes QTL
T2915 1164-1165 -LRB- denotes [
T2916 1165-1166 CD denotes 3
T2917 1166-1167 -RRB- denotes ]
T2918 1167-1168 . denotes .
T2919 1168-1385 sentence denotes Traditionally, congenic strains are developed by introgressing QTL alleles from a donor strain, whose boundaries are defined by genetic markers, on the genetic background of a recipient strain via 10 backcrosses [4].
T2920 1169-1182 RB denotes Traditionally
T2921 1205-1214 VBN denotes developed
T2922 1182-1184 , denotes ,
T2923 1184-1192 JJ denotes congenic
T2924 1193-1200 NNS denotes strains
T2925 1201-1204 VBP denotes are
T2926 1215-1217 IN denotes by
T2927 1218-1231 VBG denotes introgressing
T2928 1232-1235 NN denotes QTL
T2929 1236-1243 NNS denotes alleles
T2930 1244-1248 IN denotes from
T2931 1249-1250 DT denotes a
T2932 1257-1263 NN denotes strain
T2933 1251-1256 NN denotes donor
T2934 1263-1265 , denotes ,
T2935 1265-1270 WP$ denotes whose
T2936 1271-1281 NNS denotes boundaries
T2937 1286-1293 VBN denotes defined
T2938 1282-1285 VBP denotes are
T2939 1294-1296 IN denotes by
T2940 1297-1304 JJ denotes genetic
T2941 1305-1312 NNS denotes markers
T2942 1312-1314 , denotes ,
T2943 1314-1316 IN denotes on
T2944 1317-1320 DT denotes the
T2945 1329-1339 NN denotes background
T2946 1321-1328 JJ denotes genetic
T2947 1340-1342 IN denotes of
T2948 1343-1344 DT denotes a
T2949 1355-1361 NN denotes strain
T2950 1345-1354 NN denotes recipient
T2951 1362-1365 IN denotes via
T2952 1366-1368 CD denotes 10
T2953 1369-1380 NNS denotes backcrosses
T2954 1381-1382 -LRB- denotes [
T2955 1382-1383 CD denotes 4
T2956 1383-1384 -RRB- denotes ]
T2957 1384-1385 . denotes .
T2958 1385-1507 sentence denotes While technically straightforward this is a time consuming endeavor taking over three years to construct a single strain.
T2959 1386-1391 IN denotes While
T2960 1404-1419 JJ denotes straightforward
T2961 1392-1403 RB denotes technically
T2962 1425-1427 VBZ denotes is
T2963 1420-1424 NN denotes this
T2964 1428-1429 DT denotes a
T2965 1445-1453 NN denotes endeavor
T2966 1430-1434 NN denotes time
T2967 1435-1444 VBG denotes consuming
T2968 1454-1460 VBG denotes taking
T2969 1461-1465 IN denotes over
T2970 1466-1471 CD denotes three
T2971 1472-1477 NNS denotes years
T2972 1478-1480 TO denotes to
T2973 1481-1490 VB denotes construct
T2974 1491-1492 DT denotes a
T2975 1500-1506 NN denotes strain
T2976 1493-1499 JJ denotes single
T2977 1506-1507 . denotes .
T2978 1507-1650 sentence denotes The speed congenic approach is an alternative to this lengthy process and can reduce the number of required backcrosses from 10 to five [5,6].
T2979 1508-1511 DT denotes The
T2980 1527-1535 NN denotes approach
T2981 1512-1517 NN denotes speed
T2982 1518-1526 JJ denotes congenic
T2983 1536-1538 VBZ denotes is
T2984 1539-1541 DT denotes an
T2985 1542-1553 NN denotes alternative
T2986 1554-1556 IN denotes to
T2987 1557-1561 DT denotes this
T2988 1570-1577 NN denotes process
T2989 1562-1569 JJ denotes lengthy
T2990 1578-1581 CC denotes and
T2991 1582-1585 MD denotes can
T2992 1586-1592 VB denotes reduce
T2993 1593-1596 DT denotes the
T2994 1597-1603 NN denotes number
T2995 1604-1606 IN denotes of
T2996 1607-1615 VBN denotes required
T2997 1616-1627 NNS denotes backcrosses
T2998 1628-1632 IN denotes from
T2999 1633-1635 CD denotes 10
T3000 1636-1638 IN denotes to
T3001 1639-1643 CD denotes five
T3002 1644-1645 -LRB- denotes [
T3003 1647-1648 CD denotes 6
T3004 1645-1646 CD denotes 5
T3005 1646-1647 , denotes ,
T3006 1648-1649 -RRB- denotes ]
T3007 1649-1650 . denotes .
T3008 1650-1798 sentence denotes This strategy uses marker-assisted selection to identify male mice inheriting fewer donor alleles, than expected on average, during each backcross.
T3009 1651-1655 DT denotes This
T3010 1656-1664 NN denotes strategy
T3011 1665-1669 VBZ denotes uses
T3012 1670-1676 NN denotes marker
T3013 1677-1685 VBN denotes assisted
T3014 1676-1677 HYPH denotes -
T3015 1686-1695 NN denotes selection
T3016 1696-1698 TO denotes to
T3017 1699-1707 VB denotes identify
T3018 1708-1712 JJ denotes male
T3019 1713-1717 NNS denotes mice
T3020 1718-1728 VBG denotes inheriting
T3021 1729-1734 JJR denotes fewer
T3022 1741-1748 NNS denotes alleles
T3023 1735-1740 NN denotes donor
T3024 1748-1750 , denotes ,
T3025 1750-1754 IN denotes than
T3026 1755-1763 VBN denotes expected
T3027 1764-1766 IN denotes on
T3028 1767-1774 JJ denotes average
T3029 1774-1776 , denotes ,
T3030 1776-1782 IN denotes during
T3031 1783-1787 DT denotes each
T3032 1788-1797 NN denotes backcross
T3033 1797-1798 . denotes .
T3034 1798-1965 sentence denotes Numerous traditionally developed and speed congenics have been used to successfully isolate mouse QTL for a wide array of traits, including growth and obesity [7-13].
T3035 1799-1807 JJ denotes Numerous
T3036 1842-1851 NNS denotes congenics
T3037 1808-1821 RB denotes traditionally
T3038 1822-1831 VBN denotes developed
T3039 1832-1835 CC denotes and
T3040 1836-1841 NN denotes speed
T3041 1862-1866 VBN denotes used
T3042 1852-1856 VBP denotes have
T3043 1857-1861 VBN denotes been
T3044 1867-1869 TO denotes to
T3045 1883-1890 VB denotes isolate
T3046 1870-1882 RB denotes successfully
T3047 1891-1896 NN denotes mouse
T3048 1897-1900 NN denotes QTL
T3049 1901-1904 IN denotes for
T3050 1905-1906 DT denotes a
T3051 1912-1917 NN denotes array
T3052 1907-1911 JJ denotes wide
T3053 1918-1920 IN denotes of
T3054 1921-1927 NNS denotes traits
T3055 1927-1929 , denotes ,
T3056 1929-1938 VBG denotes including
T3057 1939-1945 NN denotes growth
T3058 1946-1949 CC denotes and
T3059 1950-1957 NN denotes obesity
T3060 1958-1959 -LRB- denotes [
T3061 1959-1960 CD denotes 7
T3062 1960-1961 SYM denotes -
T3063 1961-1963 CD denotes 13
T3064 1963-1964 -RRB- denotes ]
T3065 1964-1965 . denotes .
T3066 1965-2169 sentence denotes The C57Bl/6J-hg/hg (HG) mouse is a model of systemic overgrowth resulting from a spontaneous deletion on MMU10, which eliminates expression of the Socs2 (suppressor of cytokine signaling 2) gene [14-16].
T3067 1966-1969 DT denotes The
T3068 1990-1995 NN denotes mouse
T3069 1970-1975 NN denotes C57Bl
T3070 1982-1984 NN denotes hg
T3071 1975-1976 HYPH denotes /
T3072 1976-1978 NN denotes 6J
T3073 1978-1979 HYPH denotes -
T3074 1979-1981 NN denotes hg
T3075 1981-1982 HYPH denotes /
T3076 1985-1986 -LRB- denotes (
T3077 1986-1988 NN denotes HG
T3078 1988-1989 -RRB- denotes )
T3079 1996-1998 VBZ denotes is
T3080 1999-2000 DT denotes a
T3081 2001-2006 NN denotes model
T3082 2007-2009 IN denotes of
T3083 2010-2018 JJ denotes systemic
T3084 2019-2029 NN denotes overgrowth
T3085 2030-2039 VBG denotes resulting
T3086 2040-2044 IN denotes from
T3087 2045-2046 DT denotes a
T3088 2059-2067 NN denotes deletion
T3089 2047-2058 JJ denotes spontaneous
T3090 2068-2070 IN denotes on
T3091 2071-2076 NN denotes MMU10
T3092 2076-2078 , denotes ,
T3093 2078-2083 WDT denotes which
T3094 2084-2094 VBZ denotes eliminates
T3095 2095-2105 NN denotes expression
T3096 2106-2108 IN denotes of
T3097 2109-2112 DT denotes the
T3098 2156-2160 NN denotes gene
T3099 2113-2118 NN denotes Socs2
T3100 2119-2120 -LRB- denotes (
T3101 2120-2130 NN denotes suppressor
T3102 2131-2133 IN denotes of
T3103 2134-2142 NN denotes cytokine
T3104 2143-2152 NN denotes signaling
T3105 2153-2154 CD denotes 2
T3106 2154-2155 -RRB- denotes )
T3107 2161-2162 -LRB- denotes [
T3108 2162-2164 CD denotes 14
T3109 2164-2165 SYM denotes -
T3110 2165-2167 CD denotes 16
T3111 2167-2168 -RRB- denotes ]
T3112 2168-2169 . denotes .
T3113 2169-2357 sentence denotes The role of Socs2 in the HG phenotype was confirmed by an independently engineered Socs2-/- knockout mouse which shared a number of phenotypes in common with HG, including gigantism [17].
T3114 2170-2173 DT denotes The
T3115 2174-2178 NN denotes role
T3116 2212-2221 VBN denotes confirmed
T3117 2179-2181 IN denotes of
T3118 2182-2187 NN denotes Socs2
T3119 2188-2190 IN denotes in
T3120 2191-2194 DT denotes the
T3121 2198-2207 NN denotes phenotype
T3122 2195-2197 NN denotes HG
T3123 2208-2211 VBD denotes was
T3124 2222-2224 IN denotes by
T3125 2225-2227 DT denotes an
T3126 2271-2276 NN denotes mouse
T3127 2228-2241 RB denotes independently
T3128 2242-2252 VBN denotes engineered
T3129 2253-2258 NN denotes Socs2
T3130 2262-2270 NN denotes knockout
T3131 2258-2259 SYM denotes -
T3132 2259-2260 HYPH denotes /
T3133 2260-2261 SYM denotes -
T3134 2277-2282 WDT denotes which
T3135 2283-2289 VBD denotes shared
T3136 2290-2291 DT denotes a
T3137 2292-2298 NN denotes number
T3138 2299-2301 IN denotes of
T3139 2302-2312 NNS denotes phenotypes
T3140 2313-2315 IN denotes in
T3141 2316-2322 NN denotes common
T3142 2323-2327 IN denotes with
T3143 2328-2330 NN denotes HG
T3144 2330-2332 , denotes ,
T3145 2332-2341 VBG denotes including
T3146 2342-2351 NN denotes gigantism
T3147 2352-2353 -LRB- denotes [
T3148 2353-2355 CD denotes 17
T3149 2355-2356 -RRB- denotes ]
T3150 2356-2357 . denotes .
T3151 2357-2451 sentence denotes QTL which alter the phenotypic effects of another locus are referred to as modifier QTL [18].
T3152 2358-2361 NN denotes QTL
T3153 2418-2426 VBN denotes referred
T3154 2362-2367 WDT denotes which
T3155 2368-2373 VBP denotes alter
T3156 2374-2377 DT denotes the
T3157 2389-2396 NNS denotes effects
T3158 2378-2388 JJ denotes phenotypic
T3159 2397-2399 IN denotes of
T3160 2400-2407 DT denotes another
T3161 2408-2413 NN denotes locus
T3162 2414-2417 VBP denotes are
T3163 2427-2429 IN denotes to
T3164 2430-2432 IN denotes as
T3165 2433-2441 NN denotes modifier
T3166 2442-2445 NN denotes QTL
T3167 2446-2447 -LRB- denotes [
T3168 2447-2449 CD denotes 18
T3169 2449-2450 -RRB- denotes ]
T3170 2450-2451 . denotes .
T3171 2451-2678 sentence denotes Modifier QTL have been mapped for numerous traits and in these studies the modified locus is typically a known gene containing a spontaneously arisen or engineered mutation with major phenotypic effects, such as hg [11,19-21].
T3172 2452-2460 NN denotes Modifier
T3173 2461-2464 NN denotes QTL
T3174 2475-2481 VBN denotes mapped
T3175 2465-2469 VBP denotes have
T3176 2470-2474 VBN denotes been
T3177 2482-2485 IN denotes for
T3178 2486-2494 JJ denotes numerous
T3179 2495-2501 NNS denotes traits
T3180 2502-2505 CC denotes and
T3181 2506-2508 IN denotes in
T3182 2542-2544 VBZ denotes is
T3183 2509-2514 DT denotes these
T3184 2515-2522 NNS denotes studies
T3185 2523-2526 DT denotes the
T3186 2536-2541 NN denotes locus
T3187 2527-2535 VBN denotes modified
T3188 2545-2554 RB denotes typically
T3189 2555-2556 DT denotes a
T3190 2563-2567 NN denotes gene
T3191 2557-2562 VBN denotes known
T3192 2568-2578 VBG denotes containing
T3193 2579-2580 DT denotes a
T3194 2616-2624 NN denotes mutation
T3195 2581-2594 RB denotes spontaneously
T3196 2595-2601 VBN denotes arisen
T3197 2602-2604 CC denotes or
T3198 2605-2615 VBN denotes engineered
T3199 2625-2629 IN denotes with
T3200 2630-2635 JJ denotes major
T3201 2647-2654 NNS denotes effects
T3202 2636-2646 JJ denotes phenotypic
T3203 2654-2656 , denotes ,
T3204 2656-2660 JJ denotes such
T3205 2661-2663 IN denotes as
T3206 2664-2666 NN denotes hg
T3207 2667-2668 -LRB- denotes [
T3208 2668-2670 CD denotes 11
T3209 2670-2671 , denotes ,
T3210 2671-2673 CD denotes 19
T3211 2673-2674 SYM denotes -
T3212 2674-2676 CD denotes 21
T3213 2676-2677 -RRB- denotes ]
T3214 2677-2678 . denotes .
T3215 2678-2832 sentence denotes Epistasis forms the basis of these interactions, implying that the known gene and its modifiers are members of the same biochemical or metabolic pathway.
T3216 2679-2688 NN denotes Epistasis
T3217 2689-2694 VBZ denotes forms
T3218 2695-2698 DT denotes the
T3219 2699-2704 NN denotes basis
T3220 2705-2707 IN denotes of
T3221 2708-2713 DT denotes these
T3222 2714-2726 NNS denotes interactions
T3223 2726-2728 , denotes ,
T3224 2728-2736 VBG denotes implying
T3225 2737-2741 IN denotes that
T3226 2775-2778 VBP denotes are
T3227 2742-2745 DT denotes the
T3228 2752-2756 NN denotes gene
T3229 2746-2751 VBN denotes known
T3230 2757-2760 CC denotes and
T3231 2761-2764 PRP$ denotes its
T3232 2765-2774 NNS denotes modifiers
T3233 2779-2786 NNS denotes members
T3234 2787-2789 IN denotes of
T3235 2790-2793 DT denotes the
T3236 2824-2831 NN denotes pathway
T3237 2794-2798 JJ denotes same
T3238 2799-2810 JJ denotes biochemical
T3239 2811-2813 CC denotes or
T3240 2814-2823 JJ denotes metabolic
T3241 2831-2832 . denotes .
T3242 2832-2932 sentence denotes Different genetic backgrounds have been shown to modify the growth-enhancing effects of hg [15,22].
T3243 2833-2842 JJ denotes Different
T3244 2851-2862 NNS denotes backgrounds
T3245 2843-2850 JJ denotes genetic
T3246 2873-2878 VBN denotes shown
T3247 2863-2867 VBP denotes have
T3248 2868-2872 VBN denotes been
T3249 2879-2881 TO denotes to
T3250 2882-2888 VB denotes modify
T3251 2889-2892 DT denotes the
T3252 2910-2917 NNS denotes effects
T3253 2893-2899 NN denotes growth
T3254 2900-2909 VBG denotes enhancing
T3255 2899-2900 HYPH denotes -
T3256 2918-2920 IN denotes of
T3257 2921-2923 NN denotes hg
T3258 2924-2925 -LRB- denotes [
T3259 2928-2930 CD denotes 22
T3260 2925-2927 CD denotes 15
T3261 2927-2928 , denotes ,
T3262 2930-2931 -RRB- denotes ]
T3263 2931-2932 . denotes .
T3264 2932-3159 sentence denotes Since the primary function of Socs2 is to negatively regulate growth hormone (Gh) [23], it is likely these background effects are the result of polymorphism influencing interactions between members of the Gh signaling pathway.
T3265 2933-2938 IN denotes Since
T3266 2969-2971 VBZ denotes is
T3267 2939-2942 DT denotes the
T3268 2951-2959 NN denotes function
T3269 2943-2950 JJ denotes primary
T3270 2960-2962 IN denotes of
T3271 2963-2968 NN denotes Socs2
T3272 3024-3026 VBZ denotes is
T3273 2972-2974 TO denotes to
T3274 2986-2994 VB denotes regulate
T3275 2975-2985 RB denotes negatively
T3276 2995-3001 NN denotes growth
T3277 3002-3009 NN denotes hormone
T3278 3010-3011 -LRB- denotes (
T3279 3011-3013 NN denotes Gh
T3280 3013-3014 -RRB- denotes )
T3281 3015-3016 -LRB- denotes [
T3282 3016-3018 CD denotes 23
T3283 3018-3019 -RRB- denotes ]
T3284 3019-3021 , denotes ,
T3285 3021-3023 PRP denotes it
T3286 3027-3033 JJ denotes likely
T3287 3034-3039 DT denotes these
T3288 3051-3058 NNS denotes effects
T3289 3040-3050 NN denotes background
T3290 3059-3062 VBP denotes are
T3291 3063-3066 DT denotes the
T3292 3067-3073 NN denotes result
T3293 3074-3076 IN denotes of
T3294 3077-3089 NN denotes polymorphism
T3295 3090-3101 VBG denotes influencing
T3296 3102-3114 NNS denotes interactions
T3297 3115-3122 IN denotes between
T3298 3123-3130 NNS denotes members
T3299 3131-3133 IN denotes of
T3300 3134-3137 DT denotes the
T3301 3151-3158 NN denotes pathway
T3302 3138-3140 NN denotes Gh
T3303 3141-3150 NN denotes signaling
T3304 3158-3159 . denotes .
T3305 3159-3328 sentence denotes Thus, identification of hg modifiers has the potential to uncover novel members of metabolically important pathways or previously unknown convergences between pathways.
T3306 3160-3164 RB denotes Thus
T3307 3197-3200 VBZ denotes has
T3308 3164-3166 , denotes ,
T3309 3166-3180 NN denotes identification
T3310 3181-3183 IN denotes of
T3311 3184-3186 NN denotes hg
T3312 3187-3196 NNS denotes modifiers
T3313 3201-3204 DT denotes the
T3314 3205-3214 NN denotes potential
T3315 3215-3217 TO denotes to
T3316 3218-3225 VB denotes uncover
T3317 3226-3231 JJ denotes novel
T3318 3232-3239 NNS denotes members
T3319 3240-3242 IN denotes of
T3320 3243-3256 RB denotes metabolically
T3321 3257-3266 JJ denotes important
T3322 3267-3275 NNS denotes pathways
T3323 3276-3278 CC denotes or
T3324 3279-3289 RB denotes previously
T3325 3290-3297 JJ denotes unknown
T3326 3298-3310 NNS denotes convergences
T3327 3311-3318 IN denotes between
T3328 3319-3327 NNS denotes pathways
T3329 3327-3328 . denotes .
T3330 3328-3447 sentence denotes As an initial step, growth and carcass composition QTL were identified in a cross between CAST/EiJ (CAST) and HG [24].
T3331 3329-3331 IN denotes As
T3332 3389-3399 VBN denotes identified
T3333 3332-3334 DT denotes an
T3334 3343-3347 NN denotes step
T3335 3335-3342 JJ denotes initial
T3336 3347-3349 , denotes ,
T3337 3349-3355 NN denotes growth
T3338 3380-3383 NN denotes QTL
T3339 3356-3359 CC denotes and
T3340 3360-3367 NN denotes carcass
T3341 3368-3379 NN denotes composition
T3342 3384-3388 VBD denotes were
T3343 3400-3402 IN denotes in
T3344 3403-3404 DT denotes a
T3345 3405-3410 NN denotes cross
T3346 3411-3418 IN denotes between
T3347 3419-3423 NN denotes CAST
T3348 3424-3427 NN denotes EiJ
T3349 3423-3424 HYPH denotes /
T3350 3428-3429 -LRB- denotes (
T3351 3429-3433 NN denotes CAST
T3352 3433-3434 -RRB- denotes )
T3353 3435-3438 CC denotes and
T3354 3439-3441 NN denotes HG
T3355 3442-3443 -LRB- denotes [
T3356 3443-3445 CD denotes 24
T3357 3445-3446 -RRB- denotes ]
T3358 3446-3447 . denotes .
T3359 3447-3686 sentence denotes In the F2, mice homozygous for the hg deletion (hg/hg) and wild type (+/+) were assayed and hg modifier QTL were defined as those either absent in +/+ mice and segregating in hg/hg or loci with altered gene action dependent on background.
T3360 3448-3450 IN denotes In
T3361 3528-3535 VBN denotes assayed
T3362 3451-3454 DT denotes the
T3363 3455-3457 NN denotes F2
T3364 3457-3459 , denotes ,
T3365 3459-3463 NNS denotes mice
T3366 3464-3474 JJ denotes homozygous
T3367 3475-3478 IN denotes for
T3368 3479-3482 DT denotes the
T3369 3486-3494 NN denotes deletion
T3370 3483-3485 NN denotes hg
T3371 3495-3496 -LRB- denotes (
T3372 3499-3501 NN denotes hg
T3373 3496-3498 NN denotes hg
T3374 3498-3499 HYPH denotes /
T3375 3501-3502 -RRB- denotes )
T3376 3503-3506 CC denotes and
T3377 3507-3511 JJ denotes wild
T3378 3512-3516 NN denotes type
T3379 3517-3518 -LRB- denotes (
T3380 3518-3519 SYM denotes +
T3381 3520-3521 SYM denotes +
T3382 3519-3520 HYPH denotes /
T3383 3521-3522 -RRB- denotes )
T3384 3523-3527 VBD denotes were
T3385 3536-3539 CC denotes and
T3386 3540-3542 NN denotes hg
T3387 3543-3551 NN denotes modifier
T3388 3552-3555 NN denotes QTL
T3389 3561-3568 VBN denotes defined
T3390 3556-3560 VBD denotes were
T3391 3569-3571 IN denotes as
T3392 3572-3577 DT denotes those
T3393 3578-3584 CC denotes either
T3394 3585-3591 JJ denotes absent
T3395 3592-3594 IN denotes in
T3396 3595-3596 SYM denotes +
T3397 3597-3598 SYM denotes +
T3398 3596-3597 HYPH denotes /
T3399 3599-3603 NNS denotes mice
T3400 3604-3607 CC denotes and
T3401 3608-3619 VBG denotes segregating
T3402 3620-3622 IN denotes in
T3403 3623-3625 NN denotes hg
T3404 3626-3628 NN denotes hg
T3405 3625-3626 HYPH denotes /
T3406 3629-3631 CC denotes or
T3407 3632-3636 NNS denotes loci
T3408 3637-3641 IN denotes with
T3409 3642-3649 VBN denotes altered
T3410 3655-3661 NN denotes action
T3411 3650-3654 NN denotes gene
T3412 3662-3671 JJ denotes dependent
T3413 3672-3674 IN denotes on
T3414 3675-3685 NN denotes background
T3415 3685-3686 . denotes .
T3416 3686-4089 sentence denotes Four hg modifier QTL (Wg2 on MMU2, Carfhg2 on MMU9, Carp2 on MMU11 and Feml3 on MMU17) were identified, along with 12 additional QTL (Q1Ucd1 on MMU1 (which only reached a suggestive level of statistical significance), Wg1, Carp1, Cara1 and Feml1 on MMU2, Carfhg1 on MMU5, Wg3 on MMU8, Feml2 on MMU9, Wg4 and Cara2 on MMU11 and Carp3 and Cara3 on MMU17) whose expression was independent of the hg locus.
T3417 3687-3691 CD denotes Four
T3418 3692-3694 NN denotes hg
T3419 3704-3707 NN denotes QTL
T3420 3695-3703 NN denotes modifier
T3421 3779-3789 VBN denotes identified
T3422 3708-3709 -LRB- denotes (
T3423 3709-3712 NN denotes Wg2
T3424 3713-3715 IN denotes on
T3425 3716-3720 NN denotes MMU2
T3426 3720-3722 , denotes ,
T3427 3722-3729 NN denotes Carfhg2
T3428 3730-3732 IN denotes on
T3429 3733-3737 NN denotes MMU9
T3430 3737-3739 , denotes ,
T3431 3739-3744 NN denotes Carp2
T3432 3745-3747 IN denotes on
T3433 3748-3753 NN denotes MMU11
T3434 3754-3757 CC denotes and
T3435 3758-3763 NN denotes Feml3
T3436 3764-3766 IN denotes on
T3437 3767-3772 NN denotes MMU17
T3438 3772-3773 -RRB- denotes )
T3439 3774-3778 VBD denotes were
T3440 3789-3791 , denotes ,
T3441 3791-3796 IN denotes along
T3442 3797-3801 IN denotes with
T3443 3802-3804 CD denotes 12
T3444 3816-3819 NN denotes QTL
T3445 3805-3815 JJ denotes additional
T3446 3820-3821 -LRB- denotes (
T3447 3821-3827 NN denotes Q1Ucd1
T3448 3828-3830 IN denotes on
T3449 3831-3835 NN denotes MMU1
T3450 3836-3837 -LRB- denotes (
T3451 3837-3842 WDT denotes which
T3452 3848-3855 VBD denotes reached
T3453 3843-3847 RB denotes only
T3454 3856-3857 DT denotes a
T3455 3869-3874 NN denotes level
T3456 3858-3868 JJ denotes suggestive
T3457 3875-3877 IN denotes of
T3458 3878-3889 JJ denotes statistical
T3459 3890-3902 NN denotes significance
T3460 3902-3903 -RRB- denotes )
T3461 3903-3905 , denotes ,
T3462 3905-3908 NN denotes Wg1
T3463 3908-3910 , denotes ,
T3464 3910-3915 NN denotes Carp1
T3465 3915-3917 , denotes ,
T3466 3917-3922 NN denotes Cara1
T3467 3923-3926 CC denotes and
T3468 3927-3932 NN denotes Feml1
T3469 3933-3935 IN denotes on
T3470 3936-3940 NN denotes MMU2
T3471 3940-3942 , denotes ,
T3472 3942-3949 NN denotes Carfhg1
T3473 3950-3952 IN denotes on
T3474 3953-3957 NN denotes MMU5
T3475 3957-3959 , denotes ,
T3476 3959-3962 NN denotes Wg3
T3477 3963-3965 IN denotes on
T3478 3966-3970 NN denotes MMU8
T3479 3970-3972 , denotes ,
T3480 3972-3977 NN denotes Feml2
T3481 3978-3980 IN denotes on
T3482 3981-3985 NN denotes MMU9
T3483 3985-3987 , denotes ,
T3484 3987-3990 NN denotes Wg4
T3485 3991-3994 CC denotes and
T3486 3995-4000 NN denotes Cara2
T3487 4001-4003 IN denotes on
T3488 4004-4009 NN denotes MMU11
T3489 4010-4013 CC denotes and
T3490 4014-4019 NN denotes Carp3
T3491 4020-4023 CC denotes and
T3492 4024-4029 NN denotes Cara3
T3493 4030-4032 IN denotes on
T3494 4033-4038 NN denotes MMU17
T3495 4038-4039 -RRB- denotes )
T3496 4040-4045 WP$ denotes whose
T3497 4046-4056 NN denotes expression
T3498 4057-4060 VBD denotes was
T3499 4061-4072 JJ denotes independent
T3500 4073-4075 IN denotes of
T3501 4076-4079 DT denotes the
T3502 4083-4088 NN denotes locus
T3503 4080-4082 NN denotes hg
T3504 4088-4089 . denotes .
T3505 4089-4190 sentence denotes In the current study we have developed speed congenic strains to isolate all the aforementioned QTL.
T3506 4090-4092 IN denotes In
T3507 4119-4128 VBN denotes developed
T3508 4093-4096 DT denotes the
T3509 4105-4110 NN denotes study
T3510 4097-4104 JJ denotes current
T3511 4111-4113 PRP denotes we
T3512 4114-4118 VBP denotes have
T3513 4129-4134 NN denotes speed
T3514 4135-4143 JJ denotes congenic
T3515 4144-4151 NNS denotes strains
T3516 4152-4154 TO denotes to
T3517 4155-4162 VB denotes isolate
T3518 4163-4166 PDT denotes all
T3519 4186-4189 NN denotes QTL
T3520 4167-4170 DT denotes the
T3521 4171-4185 JJ denotes aforementioned
T3522 4189-4190 . denotes .
T3523 4190-4418 sentence denotes Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.
T3524 4191-4197 JJ denotes Single
T3525 4198-4205 NNS denotes strains
T3526 4231-4238 VBN denotes created
T3527 4206-4208 IN denotes on
T3528 4209-4211 DT denotes an
T3529 4215-4225 NN denotes background
T3530 4212-4214 NN denotes HG
T3531 4226-4230 VBD denotes were
T3532 4239-4242 IN denotes for
T3533 4243-4247 DT denotes each
T3534 4260-4266 NN denotes region
T3535 4248-4259 JJ denotes chromosomal
T3536 4267-4274 IN denotes outside
T3537 4275-4277 IN denotes of
T3538 4278-4282 NN denotes MMU2
T3539 4282-4284 , denotes ,
T3540 4284-4289 IN denotes while
T3541 4399-4408 VBN denotes developed
T3542 4290-4291 DT denotes a
T3543 4306-4311 NN denotes panel
T3544 4292-4305 JJ denotes comprehensive
T3545 4312-4314 IN denotes of
T3546 4315-4326 VBG denotes overlapping
T3547 4327-4334 NNS denotes strains
T3548 4335-4339 IN denotes with
T3549 4340-4349 JJ denotes identical
T3550 4356-4363 NNS denotes regions
T3551 4350-4355 NN denotes donor
T3552 4364-4366 IN denotes on
T3553 4367-4371 CC denotes both
T3554 4372-4374 NN denotes B6
T3555 4382-4393 NNS denotes backgrounds
T3556 4375-4378 CC denotes and
T3557 4379-4381 NN denotes HG
T3558 4394-4398 VBD denotes were
T3559 4409-4412 IN denotes for
T3560 4413-4417 NN denotes MMU2
T3561 4417-4418 . denotes .
T3562 4418-4521 sentence denotes The MMU2 panel was developed to confirm the presence of multiple QTL and test for QTL-hg interactions.
T3563 4419-4422 DT denotes The
T3564 4428-4433 NN denotes panel
T3565 4423-4427 NN denotes MMU2
T3566 4438-4447 VBN denotes developed
T3567 4434-4437 VBD denotes was
T3568 4448-4450 TO denotes to
T3569 4451-4458 VB denotes confirm
T3570 4459-4462 DT denotes the
T3571 4463-4471 NN denotes presence
T3572 4472-4474 IN denotes of
T3573 4475-4483 JJ denotes multiple
T3574 4484-4487 NN denotes QTL
T3575 4488-4491 CC denotes and
T3576 4492-4496 VB denotes test
T3577 4497-4500 IN denotes for
T3578 4501-4504 NN denotes QTL
T3579 4505-4507 NN denotes hg
T3580 4504-4505 HYPH denotes -
T3581 4508-4520 NNS denotes interactions
T3582 4520-4521 . denotes .
T3583 4521-4713 sentence denotes Additionally, based on the knowledge of potential QTL-hg interactions, genes involved in Gh signaling, whose genomic location overlapped hg modifier QTL on MMU2, 9, 11 and 17, were sequenced.
T3584 4522-4534 RB denotes Additionally
T3585 4703-4712 VBN denotes sequenced
T3586 4534-4536 , denotes ,
T3587 4536-4541 VBN denotes based
T3588 4542-4544 IN denotes on
T3589 4545-4548 DT denotes the
T3590 4549-4558 NN denotes knowledge
T3591 4559-4561 IN denotes of
T3592 4562-4571 JJ denotes potential
T3593 4579-4591 NNS denotes interactions
T3594 4572-4575 NN denotes QTL
T3595 4576-4578 NN denotes hg
T3596 4575-4576 HYPH denotes -
T3597 4591-4593 , denotes ,
T3598 4593-4598 NNS denotes genes
T3599 4599-4607 VBN denotes involved
T3600 4608-4610 IN denotes in
T3601 4611-4613 NN denotes Gh
T3602 4614-4623 NN denotes signaling
T3603 4623-4625 , denotes ,
T3604 4625-4630 WP$ denotes whose
T3605 4639-4647 NN denotes location
T3606 4631-4638 JJ denotes genomic
T3607 4648-4658 VBD denotes overlapped
T3608 4659-4661 NN denotes hg
T3609 4671-4674 NN denotes QTL
T3610 4662-4670 NN denotes modifier
T3611 4675-4677 IN denotes on
T3612 4678-4681 NN denotes MMU
T3613 4681-4682 CD denotes 2
T3614 4682-4684 , denotes ,
T3615 4684-4685 CD denotes 9
T3616 4685-4687 , denotes ,
T3617 4687-4689 CD denotes 11
T3618 4690-4693 CC denotes and
T3619 4694-4696 CD denotes 17
T3620 4696-4698 , denotes ,
T3621 4698-4702 VBD denotes were
T3622 4712-4713 . denotes .
R295 T2734 T2732 pobj mutations,by
R296 T2735 T2734 compound gene,mutations
R305 T2746 T2739 dobj complexity,mimic
R306 T2747 T2746 amod genetic,complexity
R314 T2755 T2753 pobj population,in
R315 T2756 T2755 amod human,population
R329 T2772 T2770 pobj effects,by
R330 T2773 T2772 amod small,effects
R331 T2774 T2773 prep to,small
R332 T2775 T2774 amod moderate,to
R333 T2776 T2772 amod direct,effects
R336 T2779 T2777 pobj loci,of
R337 T2780 T2779 compound trait,loci
R351 T2794 T2796 compound environment,interactions
R352 T2795 T2794 punct -,environment
R356 T2800 T2810 ccomp localized,made
R357 T2801 T2799 pobj date,To
R358 T2802 T2803 amod numerous,QTL
R359 T2803 T2800 nsubjpass QTL,localized
R360 T2804 T2805 nmod mouse,growth
R361 T2805 T2803 nmod growth,QTL
R362 T2806 T2805 cc and,growth
R363 T2807 T2805 conj obesity,growth
R364 T2808 T2800 aux have,localized
R365 T2809 T2800 auxpass been,localized
R367 T2812 T2800 parataxis 2,localized
R368 T2813 T2812 nummod 1,2
R369 T2814 T2812 punct ",",2
R381 T2826 T2824 dobj nature,determining
R382 T2827 T2826 amod specific,nature
R385 T2830 T2828 pobj variants,of
R386 T2831 T2830 amod underlying,variants
R387 T2832 T2830 amod genetic,variants
R393 T2840 T2838 advcl map,used
R394 T2841 T2840 advmod fine,map
R398 T2903 T2904 amod congenic,analysis
R399 T2845 T2846 dep which,designed
R400 T2904 T2905 nsubj analysis,method
R401 T2846 T2844 relcl designed,strains
R402 T2905 T2899 ccomp method,considers
R403 T2906 T2905 det an,method
R404 T2847 T2846 auxpass are,designed
R405 T2907 T2905 amod excellent,method
R406 T2908 T2909 aux to,confirm
R407 T2909 T2905 advcl confirm,method
R408 T2848 T2849 aux to,convert
R409 T2910 T2909 cc and,confirm
R410 T2911 T2912 advmod subsequently,map
R411 T2849 T2846 advcl convert,designed
R412 T2912 T2909 conj map,confirm
R413 T2913 T2912 advmod fine,map
R414 T2914 T2912 dobj QTL,map
R415 T2915 T2916 punct [,3
R416 T2850 T2851 det a,trait
R417 T2916 T2899 parataxis 3,considers
R418 T2917 T2916 punct ],3
R419 T2851 T2849 dobj trait,convert
R420 T2918 T2899 punct .,considers
R421 T2920 T2921 advmod Traditionally,developed
R422 T2852 T2851 amod complex,trait
R423 T2922 T2921 punct ", ",developed
R424 T2923 T2924 amod congenic,strains
R425 T2853 T2851 amod polygenic,trait
R426 T2924 T2921 nsubjpass strains,developed
R427 T2925 T2921 auxpass are,developed
R428 T2854 T2849 prep into,convert
R429 T2926 T2921 prep by,developed
R430 T2927 T2926 pcomp introgressing,by
R431 T2928 T2929 compound QTL,alleles
R432 T2929 T2927 dobj alleles,introgressing
R433 T2855 T2854 pobj one,into
R434 T2930 T2929 prep from,alleles
R435 T2931 T2932 det a,strain
R436 T2932 T2930 pobj strain,from
R437 T2933 T2932 compound donor,strain
R438 T2934 T2932 punct ", ",strain
R439 T2856 T2857 dep that,is
R440 T2935 T2936 poss whose,boundaries
R441 T2936 T2937 dep boundaries,defined
R442 T2857 T2855 relcl is,one
R443 T2937 T2932 relcl defined,strain
R444 T2858 T2859 advmod mono,oligogenic
R445 T2938 T2937 auxpass are,defined
R446 T2939 T2937 agent by,defined
R447 T2940 T2941 amod genetic,markers
R448 T2859 T2857 acomp oligogenic,is
R449 T2941 T2939 pobj markers,by
R450 T2942 T2927 punct ", ",introgressing
R451 T2943 T2927 prep on,introgressing
R452 T2860 T2859 punct -,oligogenic
R453 T2944 T2945 det the,background
R454 T2945 T2943 pobj background,on
R455 T2946 T2945 amod genetic,background
R456 T2861 T2859 cc or,oligogenic
R457 T2947 T2945 prep of,background
R458 T2948 T2949 det a,strain
R459 T2949 T2947 pobj strain,of
R460 T2862 T2837 punct .,are
R461 T2950 T2949 compound recipient,strain
R462 T2951 T2927 prep via,introgressing
R463 T2864 T2865 nsubjpass This,accomplished
R464 T2952 T2953 nummod 10,backcrosses
R465 T2953 T2951 pobj backcrosses,via
R466 T2954 T2955 punct [,4
R467 T2955 T2927 parataxis 4,introgressing
R468 T2956 T2955 punct ],4
R469 T2866 T2865 auxpass is,accomplished
R470 T2957 T2921 punct .,developed
R471 T2959 T2960 mark While,straightforward
R472 T2960 T2962 advcl straightforward,is
R473 T2867 T2865 prep by,accomplished
R474 T2961 T2960 advmod technically,straightforward
R475 T2963 T2962 nsubj this,is
R476 T2868 T2867 pcomp eliminating,by
R477 T2964 T2965 det a,endeavor
R478 T2965 T2962 attr endeavor,is
R479 T2966 T2967 npadvmod time,consuming
R480 T2869 T2868 xcomp segregating,eliminating
R481 T2967 T2965 amod consuming,endeavor
R482 T2968 T2965 acl taking,endeavor
R483 T2969 T2970 quantmod over,three
R484 T2870 T2871 amod genetic,variation
R485 T2970 T2971 nummod three,years
R486 T2971 T2968 dobj years,taking
R487 T2972 T2973 aux to,construct
R488 T2973 T2968 advcl construct,taking
R489 T2974 T2975 det a,strain
R490 T2975 T2973 dobj strain,construct
R491 T2871 T2869 dobj variation,segregating
R492 T2976 T2975 amod single,strain
R493 T2977 T2962 punct .,is
R494 T2872 T2869 prep outside,segregating
R495 T2979 T2980 det The,approach
R496 T2980 T2983 nsubj approach,is
R497 T2873 T2874 det the,locus
R498 T2981 T2982 npadvmod speed,congenic
R499 T2982 T2980 amod congenic,approach
R500 T2984 T2985 det an,alternative
R501 T2874 T2872 pobj locus,outside
R502 T2985 T2983 attr alternative,is
R503 T2986 T2985 prep to,alternative
R504 T2875 T2874 prep of,locus
R505 T2987 T2988 det this,process
R506 T2988 T2986 pobj process,to
R507 T2989 T2988 amod lengthy,process
R508 T2876 T2875 pobj interest,of
R509 T2990 T2983 cc and,is
R510 T2991 T2992 aux can,reduce
R511 T2992 T2983 conj reduce,is
R512 T2993 T2994 det the,number
R513 T2877 T2868 cc and,eliminating
R514 T2994 T2992 dobj number,reduce
R515 T2995 T2994 prep of,number
R516 T2878 T2868 conj reducing,eliminating
R517 T2996 T2997 amod required,backcrosses
R518 T2997 T2995 pobj backcrosses,of
R519 T2998 T2992 prep from,reduce
R520 T2879 T2880 det the,variation
R521 T2999 T2998 pobj 10,from
R522 T3000 T2992 prep to,reduce
R523 T3001 T3000 pobj five,to
R524 T2880 T2878 dobj variation,reducing
R525 T3002 T3003 punct [,6
R526 T3003 T2992 parataxis 6,reduce
R527 T3004 T3003 nummod 5,6
R528 T2881 T2880 amod environmental,variation
R529 T3005 T3003 punct ",",6
R530 T3006 T3003 punct ],6
R531 T3007 T2983 punct .,is
R532 T2882 T2880 acl influencing,variation
R533 T2883 T2884 det a,trait
R534 T2884 T2882 dobj trait,influencing
R535 T3009 T3010 det This,strategy
R536 T2885 T2878 prep by,reducing
R537 T3010 T3011 nsubj strategy,uses
R538 T3012 T3013 npadvmod marker,assisted
R539 T3013 T3015 amod assisted,selection
R540 T3014 T3013 punct -,assisted
R541 T3015 T3011 dobj selection,uses
R542 T2886 T2885 pcomp characterizing,by
R543 T3016 T3017 aux to,identify
R544 T3017 T3011 advcl identify,uses
R545 T3018 T3019 amod male,mice
R546 T2887 T2888 amod large,numbers
R547 T3019 T3017 dobj mice,identify
R548 T2888 T2886 dobj numbers,characterizing
R549 T3020 T3019 acl inheriting,mice
R550 T3021 T3022 amod fewer,alleles
R551 T2889 T2888 prep of,numbers
R552 T2890 T2891 advmod genetically,identical
R553 T3022 T3020 dobj alleles,inheriting
R554 T3023 T3022 compound donor,alleles
R555 T2891 T2892 amod identical,mice
R556 T3024 T3022 punct ", ",alleles
R557 T3025 T3026 mark than,expected
R558 T3026 T3022 advcl expected,alleles
R559 T2892 T2889 pobj mice,of
R560 T3027 T3020 prep on,inheriting
R561 T3028 T3027 amod average,on
R562 T3029 T3011 punct ", ",uses
R563 T2893 T2865 punct .,accomplished
R564 T3030 T3011 prep during,uses
R565 T3031 T3032 det each,backcross
R566 T2895 T2896 det The,Consortium
R567 T3032 T3030 pobj backcross,during
R568 T3033 T3011 punct .,uses
R569 T2896 T2899 nsubj Consortium,considers
R570 T3035 T3036 amod Numerous,congenics
R571 T3036 T3041 nsubjpass congenics,used
R572 T3037 T3038 advmod traditionally,developed
R573 T2897 T2898 compound Complex,Trait
R574 T3038 T3036 amod developed,congenics
R575 T3039 T3038 cc and,developed
R576 T3040 T3038 conj speed,developed
R577 T2898 T2896 compound Trait,Consortium
R578 T3042 T3041 aux have,used
R579 T3043 T3041 auxpass been,used
R580 T2900 T2896 punct (,Consortium
R581 T3044 T3045 aux to,isolate
R582 T3045 T3041 advcl isolate,used
R583 T3046 T3045 advmod successfully,isolate
R584 T3047 T3048 compound mouse,QTL
R585 T2901 T2896 appos CTC,Consortium
R586 T3048 T3045 dobj QTL,isolate
R587 T3049 T3045 prep for,isolate
R588 T2902 T2899 punct ),considers
R590 T3051 T3049 pobj array,for
R591 T3052 T3051 amod wide,array
R595 T3114 T3115 det The,role
R596 T3056 T3051 prep including,array
R597 T3057 T3056 pobj growth,including
R598 T3058 T3057 cc and,growth
R599 T3059 T3057 conj obesity,growth
R600 T3115 T3116 nsubjpass role,confirmed
R601 T3060 T3061 punct [,7
R602 T3061 T3041 parataxis 7,used
R603 T3062 T3063 punct -,13
R604 T3117 T3115 prep of,role
R605 T3063 T3061 prep 13,7
R606 T3064 T3061 punct ],7
R607 T3065 T3041 punct .,used
R608 T3067 T3068 det The,mouse
R609 T3118 T3117 pobj Socs2,of
R610 T3068 T3079 nsubj mouse,is
R611 T3069 T3070 nmod C57Bl,hg
R613 T3119 T3115 prep in,role
R614 T3071 T3070 punct /,hg
R615 T3072 T3070 nmod 6J,hg
R616 T3073 T3070 punct -,hg
R617 T3074 T3070 nmod hg,hg
R618 T3120 T3121 det the,phenotype
R619 T3075 T3070 punct /,hg
R620 T3076 T3077 punct (,HG
R621 T3077 T3070 parataxis HG,hg
R622 T3121 T3119 pobj phenotype,in
R623 T3078 T3077 punct ),HG
R624 T3080 T3081 det a,model
R625 T3122 T3121 compound HG,phenotype
R626 T3081 T3079 attr model,is
R627 T3082 T3081 prep of,model
R628 T3083 T3084 amod systemic,overgrowth
R629 T3123 T3116 auxpass was,confirmed
R630 T3084 T3082 pobj overgrowth,of
R631 T3085 T3081 acl resulting,model
R632 T3124 T3116 agent by,confirmed
R633 T3086 T3085 prep from,resulting
R634 T3087 T3088 det a,deletion
R635 T3088 T3086 pobj deletion,from
R636 T3125 T3126 det an,mouse
R637 T3089 T3088 amod spontaneous,deletion
R638 T3090 T3088 prep on,deletion
R639 T3091 T3090 pobj MMU10,on
R640 T3126 T3124 pobj mouse,by
R641 T3092 T3091 punct ", ",MMU10
R642 T3093 T3094 dep which,eliminates
R643 T3094 T3091 relcl eliminates,MMU10
R644 T3095 T3094 dobj expression,eliminates
R645 T3096 T3095 prep of,expression
R646 T3097 T3098 det the,gene
R647 T3127 T3128 advmod independently,engineered
R648 T3098 T3096 pobj gene,of
R649 T3099 T3098 nmod Socs2,gene
R650 T3100 T3099 punct (,Socs2
R651 T3101 T3099 appos suppressor,Socs2
R652 T3128 T3126 amod engineered,mouse
R653 T3102 T3101 prep of,suppressor
R654 T3103 T3104 compound cytokine,signaling
R655 T3104 T3102 pobj signaling,of
R656 T3129 T3130 nmod Socs2,knockout
R657 T3105 T3104 nummod 2,signaling
R658 T3106 T3098 punct ),gene
R659 T3107 T3108 punct [,14
R660 T3130 T3126 compound knockout,mouse
R661 T3131 T3129 punct -,Socs2
R662 T3108 T3079 parataxis 14,is
R663 T3109 T3110 punct -,16
R664 T3132 T3129 punct /,Socs2
R665 T3133 T3129 punct -,Socs2
R666 T3110 T3108 prep 16,14
R667 T3134 T3135 dep which,shared
R668 T3111 T3108 punct ],14
R669 T3112 T3079 punct .,is
R674 T3220 T3219 prep of,basis
R675 T3221 T3222 det these,interactions
R676 T3139 T3138 pobj phenotypes,of
R677 T3222 T3220 pobj interactions,of
R678 T3223 T3217 punct ", ",forms
R679 T3224 T3217 advcl implying,forms
R680 T3140 T3137 prep in,number
R681 T3225 T3226 mark that,are
R682 T3226 T3224 ccomp are,implying
R683 T3141 T3140 pobj common,in
R684 T3227 T3228 det the,gene
R685 T3228 T3226 nsubj gene,are
R686 T3229 T3228 amod known,gene
R687 T3230 T3228 cc and,gene
R688 T3142 T3141 prep with,common
R689 T3231 T3232 poss its,modifiers
R690 T3232 T3228 conj modifiers,gene
R691 T3143 T3142 pobj HG,with
R692 T3233 T3226 attr members,are
R693 T3234 T3233 prep of,members
R694 T3144 T3137 punct ", ",number
R695 T3235 T3236 det the,pathway
R696 T3236 T3234 pobj pathway,of
R697 T3237 T3236 amod same,pathway
R698 T3238 T3236 amod biochemical,pathway
R699 T3239 T3238 cc or,biochemical
R700 T3240 T3238 conj metabolic,biochemical
R701 T3241 T3217 punct .,forms
R702 T3145 T3137 prep including,number
R703 T3243 T3244 amod Different,backgrounds
R704 T3244 T3246 nsubjpass backgrounds,shown
R705 T3245 T3244 amod genetic,backgrounds
R706 T3146 T3145 pobj gigantism,including
R707 T3247 T3246 aux have,shown
R708 T3248 T3246 auxpass been,shown
R709 T3147 T3148 punct [,17
R710 T3249 T3250 aux to,modify
R711 T3148 T3116 parataxis 17,confirmed
R712 T3250 T3246 xcomp modify,shown
R713 T3251 T3252 det the,effects
R714 T3252 T3250 dobj effects,modify
R715 T3149 T3148 punct ],17
R716 T3253 T3254 npadvmod growth,enhancing
R717 T3254 T3252 amod enhancing,effects
R718 T3255 T3254 punct -,enhancing
R719 T3150 T3116 punct .,confirmed
R720 T3256 T3252 prep of,effects
R721 T3257 T3256 pobj hg,of
R722 T3258 T3259 punct [,22
R723 T3259 T3246 parataxis 22,shown
R724 T3152 T3153 nsubjpass QTL,referred
R725 T3260 T3259 nummod 15,22
R726 T3261 T3259 punct ",",22
R727 T3262 T3259 punct ],22
R728 T3154 T3155 dep which,alter
R729 T3263 T3246 punct .,shown
R730 T3265 T3266 mark Since,is
R731 T3266 T3272 advcl is,is
R732 T3267 T3268 det the,function
R733 T3155 T3152 relcl alter,QTL
R734 T3268 T3266 nsubj function,is
R735 T3269 T3268 amod primary,function
R736 T3270 T3268 prep of,function
R737 T3156 T3157 det the,effects
R738 T3271 T3270 pobj Socs2,of
R739 T3157 T3155 dobj effects,alter
R740 T3273 T3274 aux to,regulate
R741 T3274 T3266 xcomp regulate,is
R742 T3275 T3274 advmod negatively,regulate
R743 T3276 T3277 compound growth,hormone
R744 T3158 T3157 amod phenotypic,effects
R745 T3277 T3274 dobj hormone,regulate
R746 T3278 T3277 punct (,hormone
R747 T3159 T3157 prep of,effects
R748 T3279 T3277 appos Gh,hormone
R749 T3280 T3266 punct ),is
R750 T3281 T3282 punct [,23
R751 T3282 T3266 parataxis 23,is
R752 T3160 T3161 det another,locus
R753 T3283 T3282 punct ],23
R754 T3284 T3272 punct ", ",is
R755 T3285 T3272 nsubj it,is
R756 T3161 T3159 pobj locus,of
R757 T3286 T3272 acomp likely,is
R758 T3287 T3288 det these,effects
R759 T3162 T3153 auxpass are,referred
R760 T3288 T3290 nsubj effects,are
R761 T3289 T3288 compound background,effects
R762 T3163 T3153 prep to,referred
R763 T3290 T3286 advcl are,likely
R764 T3291 T3292 det the,result
R765 T3164 T3153 prep as,referred
R766 T3292 T3290 attr result,are
R767 T3293 T3292 prep of,result
R768 T3294 T3295 nsubj polymorphism,influencing
R769 T3295 T3293 pcomp influencing,of
R770 T3165 T3166 compound modifier,QTL
R771 T3296 T3295 dobj interactions,influencing
R772 T3297 T3296 prep between,interactions
R773 T3298 T3297 pobj members,between
R774 T3166 T3164 pobj QTL,as
R775 T3299 T3298 prep of,members
R776 T3300 T3301 det the,pathway
R777 T3301 T3299 pobj pathway,of
R778 T3167 T3168 punct [,18
R779 T3302 T3303 compound Gh,signaling
R780 T3303 T3301 compound signaling,pathway
R781 T3304 T3272 punct .,is
R782 T3168 T3153 parataxis 18,referred
R783 T3306 T3307 advmod Thus,has
R784 T3169 T3168 punct ],18
R785 T3308 T3307 punct ", ",has
R786 T3309 T3307 nsubj identification,has
R787 T3170 T3153 punct .,referred
R788 T3310 T3309 prep of,identification
R789 T3311 T3312 compound hg,modifiers
R790 T3312 T3310 pobj modifiers,of
R791 T3172 T3173 compound Modifier,QTL
R792 T3313 T3314 det the,potential
R793 T3314 T3307 dobj potential,has
R794 T3315 T3316 aux to,uncover
R795 T3316 T3314 acl uncover,potential
R796 T3173 T3174 nsubjpass QTL,mapped
R797 T3317 T3318 amod novel,members
R798 T3318 T3316 dobj members,uncover
R799 T3319 T3318 prep of,members
R800 T3320 T3321 advmod metabolically,important
R801 T3321 T3322 amod important,pathways
R802 T3322 T3319 pobj pathways,of
R803 T3175 T3174 aux have,mapped
R804 T3323 T3318 cc or,members
R805 T3324 T3325 advmod previously,unknown
R806 T3325 T3326 amod unknown,convergences
R807 T3176 T3174 auxpass been,mapped
R808 T3177 T3174 prep for,mapped
R809 T3326 T3318 conj convergences,members
R810 T3178 T3179 amod numerous,traits
R811 T3327 T3326 prep between,convergences
R812 T3328 T3327 pobj pathways,between
R813 T3329 T3307 punct .,has
R814 T3179 T3177 pobj traits,for
R815 T3331 T3332 prep As,identified
R816 T3180 T3174 cc and,mapped
R817 T3333 T3334 det an,step
R818 T3334 T3331 pobj step,As
R819 T3181 T3182 prep in,is
R820 T3335 T3334 amod initial,step
R821 T3336 T3332 punct ", ",identified
R822 T3337 T3338 nmod growth,QTL
R823 T3182 T3174 conj is,mapped
R824 T3338 T3332 nsubjpass QTL,identified
R825 T3339 T3337 cc and,growth
R826 T3340 T3341 compound carcass,composition
R827 T3183 T3184 det these,studies
R828 T3341 T3337 conj composition,growth
R829 T3342 T3332 auxpass were,identified
R830 T3343 T3332 prep in,identified
R831 T3184 T3181 pobj studies,in
R832 T3344 T3345 det a,cross
R833 T3345 T3343 pobj cross,in
R834 T3346 T3345 prep between,cross
R835 T3185 T3186 det the,locus
R836 T3347 T3348 compound CAST,EiJ
R837 T3348 T3346 pobj EiJ,between
R838 T3349 T3348 punct /,EiJ
R839 T3186 T3182 nsubj locus,is
R840 T3350 T3348 punct (,EiJ
R841 T3351 T3348 appos CAST,EiJ
R842 T3352 T3348 punct ),EiJ
R843 T3187 T3186 amod modified,locus
R844 T3353 T3348 cc and,EiJ
R845 T3354 T3348 conj HG,EiJ
R846 T3355 T3356 punct [,24
R847 T3188 T3182 advmod typically,is
R848 T3356 T3332 parataxis 24,identified
R849 T3357 T3356 punct ],24
R850 T3358 T3332 punct .,identified
R851 T3189 T3190 det a,gene
R852 T3360 T3361 prep In,assayed
R853 T3362 T3363 det the,F2
R854 T3363 T3360 pobj F2,In
R855 T3364 T3361 punct ", ",assayed
R856 T3190 T3182 attr gene,is
R857 T3365 T3361 nsubjpass mice,assayed
R858 T3366 T3365 amod homozygous,mice
R859 T3191 T3190 amod known,gene
R860 T3367 T3366 prep for,homozygous
R861 T3192 T3190 acl containing,gene
R862 T3368 T3369 det the,deletion
R863 T3369 T3367 pobj deletion,for
R864 T3193 T3194 det a,mutation
R865 T3370 T3369 compound hg,deletion
R866 T3371 T3372 punct (,hg
R867 T3372 T3369 parataxis hg,deletion
R868 T3194 T3192 dobj mutation,containing
R869 T3373 T3372 compound hg,hg
R870 T3374 T3372 punct /,hg
R871 T3375 T3372 punct ),hg
R872 T3195 T3196 advmod spontaneously,arisen
R873 T3376 T3366 cc and,homozygous
R874 T3196 T3194 amod arisen,mutation
R875 T3377 T3378 amod wild,type
R876 T3378 T3366 conj type,homozygous
R877 T3379 T3378 punct (,type
R878 T3380 T3381 punct +,+
R879 T3197 T3196 cc or,arisen
R880 T3381 T3378 appos +,type
R881 T3382 T3381 punct /,+
R882 T3383 T3361 punct ),assayed
R883 T3198 T3196 conj engineered,arisen
R884 T3384 T3361 auxpass were,assayed
R885 T3385 T3361 cc and,assayed
R886 T3199 T3194 prep with,mutation
R887 T3386 T3387 compound hg,modifier
R888 T3387 T3388 compound modifier,QTL
R889 T3388 T3389 nsubjpass QTL,defined
R890 T3389 T3361 conj defined,assayed
R891 T3200 T3201 amod major,effects
R892 T3390 T3389 auxpass were,defined
R893 T3391 T3389 prep as,defined
R894 T3392 T3391 pobj those,as
R895 T3201 T3199 pobj effects,with
R896 T3393 T3392 preconj either,those
R897 T3394 T3392 amod absent,those
R898 T3202 T3201 amod phenotypic,effects
R899 T3395 T3394 prep in,absent
R900 T3396 T3397 punct +,+
R901 T3397 T3399 punct +,mice
R902 T3398 T3397 punct /,+
R903 T3203 T3194 punct ", ",mutation
R904 T3399 T3395 pobj mice,in
R905 T3400 T3394 cc and,absent
R906 T3401 T3394 conj segregating,absent
R907 T3402 T3401 prep in,segregating
R908 T3403 T3404 compound hg,hg
R909 T3404 T3402 pobj hg,in
R910 T3204 T3205 amod such,as
R911 T3405 T3404 punct /,hg
R912 T3406 T3392 cc or,those
R913 T3407 T3392 conj loci,those
R914 T3408 T3407 prep with,loci
R915 T3205 T3194 prep as,mutation
R916 T3409 T3410 amod altered,action
R917 T3410 T3408 pobj action,with
R918 T3411 T3410 compound gene,action
R919 T3206 T3205 pobj hg,as
R920 T3412 T3410 amod dependent,action
R921 T3413 T3412 prep on,dependent
R922 T3414 T3413 pobj background,on
R923 T3207 T3208 punct [,11
R924 T3415 T3389 punct .,defined
R925 T3208 T3182 parataxis 11,is
R926 T3417 T3418 nummod Four,hg
R927 T3418 T3419 compound hg,QTL
R928 T3419 T3421 nsubjpass QTL,identified
R929 T3420 T3419 compound modifier,QTL
R930 T3209 T3208 punct ",",11
R931 T3422 T3419 punct (,QTL
R932 T3423 T3419 appos Wg2,QTL
R933 T3210 T3208 appos 19,11
R934 T3424 T3423 prep on,Wg2
R935 T3425 T3424 pobj MMU2,on
R936 T3426 T3423 punct ", ",Wg2
R937 T3211 T3212 punct -,21
R938 T3427 T3423 conj Carfhg2,Wg2
R939 T3428 T3427 prep on,Carfhg2
R940 T3429 T3428 pobj MMU9,on
R941 T3212 T3210 prep 21,19
R942 T3430 T3427 punct ", ",Carfhg2
R943 T3213 T3208 punct ],11
R944 T3214 T3182 punct .,is
R945 T3431 T3427 conj Carp2,Carfhg2
R946 T3216 T3217 nsubj Epistasis,forms
R947 T3432 T3431 prep on,Carp2
R948 T3433 T3432 pobj MMU11,on
R949 T3434 T3431 cc and,Carp2
R950 T3435 T3431 conj Feml3,Carp2
R951 T3218 T3219 det the,basis
R952 T3436 T3435 prep on,Feml3
R953 T3437 T3436 pobj MMU17,on
R954 T3438 T3419 punct ),QTL
R955 T3219 T3217 dobj basis,forms
R961 T3444 T3442 pobj QTL,with
R962 T3445 T3444 amod additional,QTL
R963 T3537 T3536 prep of,outside
R964 T3446 T3444 punct (,QTL
R965 T3447 T3444 appos Q1Ucd1,QTL
R966 T3448 T3447 prep on,Q1Ucd1
R967 T3538 T3537 pobj MMU2,of
R968 T3449 T3448 pobj MMU1,on
R969 T3450 T3444 punct (,QTL
R970 T3539 T3526 punct ", ",created
R971 T3451 T3452 dep which,reached
R972 T3452 T3444 relcl reached,QTL
R973 T3453 T3452 advmod only,reached
R974 T3540 T3541 mark while,developed
R975 T3454 T3455 det a,level
R976 T3455 T3452 dobj level,reached
R977 T3456 T3455 amod suggestive,level
R978 T3541 T3526 advcl developed,created
R979 T3457 T3455 prep of,level
R980 T3458 T3459 amod statistical,significance
R981 T3459 T3457 pobj significance,of
R982 T3460 T3444 punct ),QTL
R983 T3542 T3543 det a,panel
R984 T3461 T3444 punct ", ",QTL
R985 T3462 T3444 appos Wg1,QTL
R986 T3543 T3541 nsubjpass panel,developed
R987 T3463 T3462 punct ", ",Wg1
R988 T3464 T3462 conj Carp1,Wg1
R989 T3465 T3464 punct ", ",Carp1
R990 T3544 T3543 amod comprehensive,panel
R991 T3466 T3464 conj Cara1,Carp1
R992 T3467 T3466 cc and,Cara1
R993 T3468 T3466 conj Feml1,Cara1
R994 T3545 T3543 prep of,panel
R995 T3469 T3466 prep on,Cara1
R996 T3470 T3469 pobj MMU2,on
R997 T3471 T3466 punct ", ",Cara1
R998 T3546 T3547 amod overlapping,strains
R999 T3472 T3466 conj Carfhg1,Cara1
R1000 T3473 T3472 prep on,Carfhg1
R1001 T3474 T3473 pobj MMU5,on
R1002 T3547 T3545 pobj strains,of
R1003 T3475 T3472 punct ", ",Carfhg1
R1004 T3476 T3472 conj Wg3,Carfhg1
R1005 T3477 T3476 prep on,Wg3
R1006 T3548 T3547 prep with,strains
R1007 T3478 T3477 pobj MMU8,on
R1008 T3479 T3476 punct ", ",Wg3
R1009 T3480 T3476 conj Feml2,Wg3
R1010 T3481 T3480 prep on,Feml2
R1011 T3482 T3481 pobj MMU9,on
R1012 T3483 T3480 punct ", ",Feml2
R1013 T3549 T3550 amod identical,regions
R1014 T3484 T3480 conj Wg4,Feml2
R1015 T3485 T3484 cc and,Wg4
R1016 T3486 T3484 conj Cara2,Wg4
R1017 T3550 T3548 pobj regions,with
R1018 T3487 T3484 prep on,Wg4
R1019 T3488 T3487 pobj MMU11,on
R1020 T3489 T3484 cc and,Wg4
R1021 T3490 T3484 conj Carp3,Wg4
R1022 T3551 T3550 compound donor,regions
R1023 T3491 T3490 cc and,Carp3
R1024 T3492 T3490 conj Cara3,Carp3
R1025 T3552 T3543 prep on,panel
R1026 T3493 T3490 prep on,Carp3
R1027 T3494 T3493 pobj MMU17,on
R1028 T3495 T3490 punct ),Carp3
R1029 T3553 T3554 preconj both,B6
R1030 T3554 T3555 nmod B6,backgrounds
R1031 T3496 T3497 poss whose,expression
R1032 T3555 T3552 pobj backgrounds,on
R1033 T3497 T3498 dep expression,was
R1034 T3498 T3490 relcl was,Carp3
R1035 T3499 T3498 acomp independent,was
R1036 T3556 T3554 cc and,B6
R1037 T3500 T3499 prep of,independent
R1038 T3501 T3502 det the,locus
R1039 T3502 T3500 pobj locus,of
R1040 T3557 T3554 conj HG,B6
R1041 T3503 T3502 compound hg,locus
R1042 T3504 T3421 punct .,identified
R1043 T3558 T3541 auxpass were,developed
R1044 T3506 T3507 prep In,developed
R1045 T3559 T3541 prep for,developed
R1046 T3508 T3509 det the,study
R1047 T3509 T3506 pobj study,In
R1048 T3510 T3509 amod current,study
R1049 T3511 T3507 nsubj we,developed
R1050 T3560 T3559 pobj MMU2,for
R1051 T3512 T3507 aux have,developed
R1052 T3513 T3514 npadvmod speed,congenic
R1053 T3514 T3515 amod congenic,strains
R1054 T3561 T3526 punct .,created
R1055 T3515 T3507 dobj strains,developed
R1056 T3516 T3517 aux to,isolate
R1057 T3517 T3507 advcl isolate,developed
R1058 T3563 T3564 det The,panel
R1059 T3518 T3519 predet all,QTL
R1060 T3519 T3517 dobj QTL,isolate
R1061 T3520 T3519 det the,QTL
R1062 T3521 T3519 amod aforementioned,QTL
R1063 T3522 T3507 punct .,developed
R1064 T3524 T3525 amod Single,strains
R1065 T3564 T3566 nsubjpass panel,developed
R1066 T3525 T3526 nsubjpass strains,created
R1067 T3527 T3525 prep on,strains
R1068 T3565 T3564 compound MMU2,panel
R1069 T3528 T3529 det an,background
R1070 T3529 T3527 pobj background,on
R1071 T3530 T3529 compound HG,background
R1072 T3567 T3566 auxpass was,developed
R1073 T3531 T3526 auxpass were,created
R1074 T3532 T3526 prep for,created
R1075 T3568 T3569 aux to,confirm
R1076 T3533 T3534 det each,region
R1077 T3569 T3566 advcl confirm,developed
R1078 T3534 T3532 pobj region,for
R1079 T3535 T3534 amod chromosomal,region
R1080 T3536 T3534 prep outside,region
R1090 T3579 T3581 compound hg,interactions
R1091 T3580 T3579 punct -,hg
R1102 T3593 T3591 pobj interactions,of
R1103 T3594 T3595 compound QTL,hg
R1105 T3596 T3595 punct -,hg
R1114 T3605 T3607 dep location,overlapped
R1115 T3606 T3605 amod genomic,location
R1118 T3609 T3607 dobj QTL,overlapped
R1119 T3610 T3609 compound modifier,QTL
R278 T2716 T2717 det The,use
R279 T2717 T2718 nsubj use,provided
R280 T2719 T2717 prep of,use
R281 T2720 T2721 compound mouse,models
R282 T2721 T2719 pobj models,of
R283 T2722 T2718 aux has,provided
R284 T2723 T2724 amod valuable,insight
R285 T2724 T2718 dobj insight,provided
R286 T2725 T2724 prep into,insight
R287 T2726 T2727 det the,etiology
R288 T2727 T2725 pobj etiology,into
R289 T2728 T2727 prep of,etiology
R290 T2729 T2730 amod monogenic,syndromes
R291 T2730 T2728 pobj syndromes,of
R292 T2731 T2730 acl caused,syndromes
R293 T2732 T2731 agent by,caused
R294 T2733 T2734 amod single,mutations
R297 T2736 T2718 punct .,provided
R298 T2738 T2739 advmod However,mimic
R299 T2740 T2739 punct ", ",mimic
R300 T2741 T2742 amod such,models
R301 T2742 T2739 nsubj models,mimic
R302 T2743 T2739 aux do,mimic
R303 T2744 T2739 neg not,mimic
R304 T2745 T2746 det the,complexity
R307 T2748 T2746 prep of,complexity
R308 T2749 T2750 compound disease,traits
R309 T2750 T2748 pobj traits,of
R310 T2751 T2752 advmod commonly,seen
R311 T2752 T2750 acl seen,traits
R312 T2753 T2752 prep in,seen
R313 T2754 T2755 det the,population
R316 T2757 T2739 punct .,mimic
R317 T2759 T2760 compound Complex,traits
R318 T2760 T2761 nsubjpass traits,influenced
R319 T2762 T2760 punct ", ",traits
R320 T2763 T2764 amod such,as
R321 T2764 T2760 prep as,traits
R322 T2765 T2766 amod polygenic,growth
R323 T2766 T2764 pobj growth,as
R324 T2767 T2766 cc and,growth
R325 T2768 T2766 conj obesity,growth
R326 T2769 T2761 auxpass are,influenced
R327 T2770 T2761 agent by,influenced
R328 T2771 T2772 det the,effects
R334 T2777 T2772 prep of,effects
R335 T2778 T2779 amod quantitative,loci
R338 T2781 T2779 punct (,loci
R339 T2782 T2779 appos QTL,loci
R340 T2783 T2779 punct ),loci
R341 T2784 T2779 punct ", ",loci
R342 T2785 T2779 conj epistasis,loci
R343 T2786 T2785 prep between,epistasis
R344 T2787 T2788 compound QTL,alleles
R345 T2788 T2786 pobj alleles,between
R346 T2789 T2785 punct ", ",epistasis
R347 T2790 T2791 amod environmental,perturbations
R348 T2791 T2785 conj perturbations,epistasis
R349 T2792 T2791 cc and,perturbations
R350 T2793 T2794 compound QTL,environment
R353 T2796 T2791 conj interactions,perturbations
R354 T2797 T2761 punct .,influenced
R355 T2799 T2800 prep To,localized
R366 T2811 T2812 punct [,2
R370 T2815 T2812 punct ],2
R371 T2816 T2810 punct ", ",made
R372 T2817 T2810 advmod however,made
R373 T2818 T2810 punct ", ",made
R374 T2819 T2820 amod little,progress
R375 T2820 T2810 nsubjpass progress,made
R376 T2821 T2810 aux has,made
R377 T2822 T2810 auxpass been,made
R378 T2823 T2810 prep in,made
R379 T2824 T2823 pcomp determining,in
R380 T2825 T2826 det the,nature
R383 T2828 T2826 prep of,nature
R384 T2829 T2830 det the,variants
R388 T2833 T2810 punct .,made
R389 T2835 T2836 nummod One,resource
R390 T2836 T2837 nsubj resource,are
R391 T2838 T2836 acl used,resource
R392 T2839 T2840 aux to,map
R395 T2842 T2840 dobj QTL,map
R396 T2843 T2844 amod congenic,strains
R397 T2844 T2837 attr strains,are
R589 T3050 T3051 det a,array
R592 T3053 T3051 prep of,array
R593 T3054 T3053 pobj traits,of
R594 T3055 T3051 punct ", ",array
R612 T3070 T3068 nmod hg,mouse
R670 T3135 T3126 relcl shared,mouse
R671 T3136 T3137 det a,number
R672 T3137 T3135 dobj number,shared
R673 T3138 T3137 prep of,number
R956 T3439 T3421 auxpass were,identified
R957 T3440 T3421 punct ", ",identified
R958 T3441 T3421 prep along,identified
R959 T3442 T3441 prep with,along
R960 T3443 T3444 nummod 12,QTL
R1081 T3570 T3571 det the,presence
R1082 T3571 T3569 dobj presence,confirm
R1083 T3572 T3571 prep of,presence
R1084 T3573 T3574 amod multiple,QTL
R1085 T3574 T3572 pobj QTL,of
R1086 T3575 T3569 cc and,confirm
R1087 T3576 T3569 conj test,confirm
R1088 T3577 T3576 prep for,test
R1089 T3578 T3579 compound QTL,hg
R1092 T3581 T3577 pobj interactions,for
R1093 T3582 T3566 punct .,developed
R1094 T3584 T3585 advmod Additionally,sequenced
R1095 T3586 T3585 punct ", ",sequenced
R1096 T3587 T3585 prep based,sequenced
R1097 T3588 T3587 prep on,based
R1098 T3589 T3590 det the,knowledge
R1099 T3590 T3588 pobj knowledge,on
R1100 T3591 T3590 prep of,knowledge
R1101 T3592 T3593 amod potential,interactions
R1104 T3595 T3593 compound hg,interactions
R1106 T3597 T3585 punct ", ",sequenced
R1107 T3598 T3585 nsubjpass genes,sequenced
R1108 T3599 T3598 acl involved,genes
R1109 T3600 T3599 prep in,involved
R1110 T3601 T3602 compound Gh,signaling
R1111 T3602 T3600 pobj signaling,in
R1112 T3603 T3598 punct ", ",genes
R1113 T3604 T3605 poss whose,location
R1116 T3607 T3598 relcl overlapped,genes
R1117 T3608 T3609 compound hg,QTL
R1120 T3611 T3609 prep on,QTL
R1121 T3612 T3613 nmod MMU,2
R1122 T3613 T3611 pobj 2,on
R1123 T3614 T3613 punct ", ",2
R1124 T3615 T3613 conj 9,2
R1125 T3616 T3615 punct ", ",9
R1126 T3617 T3615 conj 11,9
R1127 T3618 T3617 cc and,11
R1128 T3619 T3617 conj 17,11
R1129 T3620 T3585 punct ", ",sequenced
R1130 T3621 T3585 auxpass were,sequenced
R1131 T3622 T3585 punct .,sequenced

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2618 22-27 NCBITaxon:10088 denotes mouse
T2619 90-95 SO_EXT:0000704 denotes genic
T2620 123-127 SO_EXT:0000704 denotes gene
T2621 128-137 SO_EXT:sequence_alteration_entity_or_process denotes mutations
T2622 177-184 SO_EXT:0000704 denotes genetic
T2623 235-240 NCBITaxon:9606 denotes human
T2624 281-286 SO_EXT:0000704 denotes genic
T2625 287-293 GO_EXT:biological_growth_entity_or_process denotes growth
T2626 364-387 SO_EXT:0000771 denotes quantitative trait loci
T2627 389-392 SO_EXT:0000771 denotes QTL
T2628 413-416 SO_EXT:0000771 denotes QTL
T2629 417-424 SO_EXT:0001023 denotes alleles
T2630 458-461 SO_EXT:0000771 denotes QTL
T2631 505-510 NCBITaxon:10088 denotes mouse
T2632 511-517 GO_EXT:biological_growth_entity_or_process denotes growth
T2633 530-533 SO_EXT:0000771 denotes QTL
T2634 653-660 SO_EXT:0000704 denotes genetic
T2635 661-669 SO_EXT:sequence_variant_entity denotes variants
T2636 701-704 SO_EXT:0000771 denotes QTL
T2637 770-775 SO_EXT:0000704 denotes genic
T2638 813-818 SO_EXT:0000704 denotes genic
T2639 868-875 SO_EXT:0000704 denotes genetic
T2640 876-885 SO_EXT:sequence_variation_entity_or_quality denotes variation
T2641 1012-1023 SO_EXT:0000704 denotes genetically
T2642 1034-1038 NCBITaxon:10088 denotes mice
T2643 1160-1163 SO_EXT:0000771 denotes QTL
T2644 1232-1235 SO_EXT:0000771 denotes QTL
T2645 1236-1243 SO_EXT:0001023 denotes alleles
T2646 1297-1312 SO_EXT:0001645 denotes genetic markers
T2647 1305-1312 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes markers
T2648 1321-1328 SO_EXT:0000704 denotes genetic
T2649 1670-1676 CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag denotes marker
T2650 1708-1712 PATO_UBERON_EXT:male_or_bearer_of_maleness denotes male
T2651 1713-1717 NCBITaxon:10088 denotes mice
T2652 1741-1748 SO_EXT:0001023 denotes alleles
T2653 1891-1896 NCBITaxon:10088 denotes mouse
T2654 1897-1900 SO_EXT:0000771 denotes QTL
T2655 1939-1945 GO_EXT:biological_growth_entity_or_process denotes growth
T2656 1990-1995 NCBITaxon:10088 denotes mouse
T2657 2023-2029 GO_EXT:biological_growth_entity_or_process denotes growth
T2658 2059-2067 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2659 2095-2105 GO:0010467 denotes expression
T2660 2113-2118 PR_EXT:000015393 denotes Socs2
T2661 2120-2154 PR_EXT:000015393 denotes suppressor of cytokine signaling 2
T2662 2134-2142 GO_EXT:0005125 denotes cytokine
T2663 2134-2152 GO:0019221 denotes cytokine signaling
T2664 2156-2160 SO_EXT:0000704 denotes gene
T2665 2182-2187 PR_EXT:000015393 denotes Socs2
T2666 2253-2258 PR_EXT:000015393 denotes Socs2
T2667 2258-2259 SO_EXT:sequence_nullness_or_absence denotes -
T2668 2260-2261 SO_EXT:sequence_nullness_or_absence denotes -
T2669 2271-2276 NCBITaxon:10088 denotes mouse
T2670 2358-2361 SO_EXT:0000771 denotes QTL
T2671 2442-2445 SO_EXT:0000771 denotes QTL
T2672 2461-2464 SO_EXT:0000771 denotes QTL
T2673 2527-2535 SO_EXT:sequence_alteration_process denotes modified
T2674 2563-2567 SO_EXT:0000704 denotes gene
T2675 2616-2624 SO_EXT:sequence_alteration_entity_or_process denotes mutation
T2676 2752-2756 SO_EXT:0000704 denotes gene
T2677 2799-2810 CHEBI_EXT:biochemical denotes biochemical
T2678 2814-2823 GO:0008152 denotes metabolic
T2679 2843-2850 SO_EXT:0000704 denotes genetic
T2680 2893-2899 GO_EXT:biological_growth_entity_or_process denotes growth
T2681 2963-2968 PR_EXT:000015393 denotes Socs2
T2682 2975-2994 GO_EXT:negative_regulation denotes negatively regulate
T2683 2995-3001 GO_EXT:biological_growth_entity_or_process denotes growth
T2684 2995-3009 CHEBI_GO_PR_EXT:growth_hormone denotes growth hormone
T2685 3011-3013 CHEBI_GO_PR_EXT:growth_hormone denotes Gh
T2686 3077-3089 SO_EXT:polymorphism denotes polymorphism
T2687 3138-3140 CHEBI_GO_PR_EXT:growth_hormone denotes Gh
T2688 3138-3158 GO:0060396 denotes Gh signaling pathway
T2689 3243-3256 GO:0008152 denotes metabolically
T2690 3349-3355 GO_EXT:biological_growth_entity_or_process denotes growth
T2691 3360-3367 UBERON:0008979 denotes carcass
T2692 3380-3383 SO_EXT:0000771 denotes QTL
T2693 3459-3463 NCBITaxon:10088 denotes mice
T2694 3486-3494 SO_EXT:sequence_deletion_entity_or_process denotes deletion
T2695 3507-3516 SO_EXT:wild_type_entity_or_quality denotes wild type
T2696 3518-3519 SO_EXT:normal_or_wild_type_or_present denotes +
T2697 3520-3521 SO_EXT:normal_or_wild_type_or_present denotes +
T2698 3552-3555 SO_EXT:0000771 denotes QTL
T2699 3595-3596 SO_EXT:normal_or_wild_type_or_present denotes +
T2700 3597-3598 SO_EXT:normal_or_wild_type_or_present denotes +
T2701 3599-3603 NCBITaxon:10088 denotes mice
T2702 3650-3654 SO_EXT:0000704 denotes gene
T2703 3704-3707 SO_EXT:0000771 denotes QTL
T2704 3816-3819 SO_EXT:0000771 denotes QTL
T2705 4046-4056 GO:0010467 denotes expression
T2706 4186-4189 SO_EXT:0000771 denotes QTL
T2707 4248-4266 GO_SO_EXT:chromosomal_part_or_position_or_region_or_site denotes chromosomal region
T2708 4484-4487 SO_EXT:0000771 denotes QTL
T2709 4501-4504 SO_EXT:0000771 denotes QTL
T2710 4572-4575 SO_EXT:0000771 denotes QTL
T2711 4593-4598 SO_EXT:0000704 denotes genes
T2712 4611-4613 CHEBI_GO_PR_EXT:growth_hormone denotes Gh
T2713 4611-4623 GO:0060396 denotes Gh signaling
T2714 4631-4638 SO_EXT:0001026 denotes genomic
T2715 4671-4674 SO_EXT:0000771 denotes QTL

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T2553 22-27 NCBITaxon:10088 denotes mouse
T2554 90-95 SO:0000704 denotes genic
T2555 123-127 SO:0000704 denotes gene
T2556 177-184 SO:0000704 denotes genetic
T2557 235-240 NCBITaxon:9606 denotes human
T2558 281-286 SO:0000704 denotes genic
T2559 364-387 SO:0000771 denotes quantitative trait loci
T2560 389-392 SO:0000771 denotes QTL
T2561 413-416 SO:0000771 denotes QTL
T2562 417-424 SO:0001023 denotes alleles
T2563 458-461 SO:0000771 denotes QTL
T2564 505-510 NCBITaxon:10088 denotes mouse
T2565 530-533 SO:0000771 denotes QTL
T2566 653-660 SO:0000704 denotes genetic
T2567 701-704 SO:0000771 denotes QTL
T2568 770-775 SO:0000704 denotes genic
T2569 813-818 SO:0000704 denotes genic
T2570 868-875 SO:0000704 denotes genetic
T2571 1012-1023 SO:0000704 denotes genetically
T2572 1034-1038 NCBITaxon:10088 denotes mice
T2573 1160-1163 SO:0000771 denotes QTL
T2574 1232-1235 SO:0000771 denotes QTL
T2575 1236-1243 SO:0001023 denotes alleles
T2576 1297-1312 SO:0001645 denotes genetic markers
T2577 1321-1328 SO:0000704 denotes genetic
T2578 1713-1717 NCBITaxon:10088 denotes mice
T2579 1741-1748 SO:0001023 denotes alleles
T2580 1891-1896 NCBITaxon:10088 denotes mouse
T2581 1897-1900 SO:0000771 denotes QTL
T2582 1990-1995 NCBITaxon:10088 denotes mouse
T2583 2095-2105 GO:0010467 denotes expression
T2584 2113-2118 PR:000015393 denotes Socs2
T2585 2120-2154 PR:000015393 denotes suppressor of cytokine signaling 2
T2586 2134-2152 GO:0019221 denotes cytokine signaling
T2587 2156-2160 SO:0000704 denotes gene
T2588 2182-2187 PR:000015393 denotes Socs2
T2589 2253-2258 PR:000015393 denotes Socs2
T2590 2271-2276 NCBITaxon:10088 denotes mouse
T2591 2358-2361 SO:0000771 denotes QTL
T2592 2442-2445 SO:0000771 denotes QTL
T2593 2461-2464 SO:0000771 denotes QTL
T2594 2563-2567 SO:0000704 denotes gene
T2595 2752-2756 SO:0000704 denotes gene
T2596 2814-2823 GO:0008152 denotes metabolic
T2597 2843-2850 SO:0000704 denotes genetic
T2598 2963-2968 PR:000015393 denotes Socs2
T2599 3138-3158 GO:0060396 denotes Gh signaling pathway
T2600 3243-3256 GO:0008152 denotes metabolically
T2601 3360-3367 UBERON:0008979 denotes carcass
T2602 3380-3383 SO:0000771 denotes QTL
T2603 3459-3463 NCBITaxon:10088 denotes mice
T2604 3552-3555 SO:0000771 denotes QTL
T2605 3599-3603 NCBITaxon:10088 denotes mice
T2606 3650-3654 SO:0000704 denotes gene
T2607 3704-3707 SO:0000771 denotes QTL
T2608 3816-3819 SO:0000771 denotes QTL
T2609 4046-4056 GO:0010467 denotes expression
T2610 4186-4189 SO:0000771 denotes QTL
T2611 4484-4487 SO:0000771 denotes QTL
T2612 4501-4504 SO:0000771 denotes QTL
T2613 4572-4575 SO:0000771 denotes QTL
T2614 4593-4598 SO:0000704 denotes genes
T2615 4611-4623 GO:0060396 denotes Gh signaling
T2616 4631-4638 SO:0001026 denotes genomic
T2617 4671-4674 SO:0000771 denotes QTL