PMC:1482699 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T574	7-11	JJ	denotes	wide
T575	0-82	sentence	denotes	Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
T576	6-7	HYPH	denotes	-
T577	12-21	NN	denotes	isolation
T578	22-24	IN	denotes	of
T579	25-31	NN	denotes	growth
T580	44-47	NN	denotes	QTL
T581	32-35	CC	denotes	and
T582	36-43	NN	denotes	obesity
T583	48-53	VBG	denotes	using
T584	54-59	NN	denotes	mouse
T585	60-65	NN	denotes	speed
T586	66-74	JJ	denotes	congenic
T587	75-82	NNS	denotes	strains
T588	82-83	sentence	denotes
T589	93-103	sentence	denotes	Background
T590	93-103	NN	denotes	Background
T591	103-318	sentence	denotes	High growth (hg) modifier and background independent quantitative trait loci (QTL) affecting growth, adiposity and carcass composition were previously identified on mouse chromosomes (MMU) 1, 2, 5, 8, 9, 11 and 17.
T592	104-108	JJ	denotes	High
T593	109-115	NN	denotes	growth
T594	121-129	NN	denotes	modifier
T595	116-117	-LRB-	denotes	(
T596	117-119	NN	denotes	hg
T597	119-120	-RRB-	denotes	)
T598	255-265	VBN	denotes	identified
T599	130-133	CC	denotes	and
T600	134-144	NN	denotes	background
T601	145-156	JJ	denotes	independent
T602	176-180	NNS	denotes	loci
T603	157-169	JJ	denotes	quantitative
T604	170-175	NN	denotes	trait
T605	181-182	-LRB-	denotes	(
T606	182-185	NN	denotes	QTL
T607	185-186	-RRB-	denotes	)
T608	187-196	VBG	denotes	affecting
T609	197-203	NN	denotes	growth
T610	203-205	,	denotes	,
T611	205-214	NN	denotes	adiposity
T612	215-218	CC	denotes	and
T613	219-226	NN	denotes	carcass
T614	227-238	NN	denotes	composition
T615	239-243	VBD	denotes	were
T616	244-254	RB	denotes	previously
T617	266-268	IN	denotes	on
T618	269-274	NN	denotes	mouse
T619	275-286	NNS	denotes	chromosomes
T620	287-288	-LRB-	denotes	(
T621	288-291	NN	denotes	MMU
T622	291-292	-RRB-	denotes	)
T623	293-294	CD	denotes	1
T624	294-296	,	denotes	,
T625	296-297	CD	denotes	2
T626	297-299	,	denotes	,
T627	299-300	CD	denotes	5
T628	300-302	,	denotes	,
T629	302-303	CD	denotes	8
T630	303-305	,	denotes	,
T631	305-306	CD	denotes	9
T632	306-308	,	denotes	,
T633	308-310	CD	denotes	11
T634	311-314	CC	denotes	and
T635	315-317	CD	denotes	17
T636	317-318	.	denotes	.
T637	318-548	sentence	denotes	To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds.
T638	319-321	TO	denotes	To
T639	322-329	VB	denotes	confirm
T640	407-416	VBN	denotes	developed
T641	330-333	CC	denotes	and
T642	334-341	RB	denotes	further
T643	342-354	VB	denotes	characterize
T644	355-359	DT	denotes	each
T645	360-363	NN	denotes	QTL
T646	363-365	,	denotes	,
T647	365-368	CD	denotes	two
T648	369-375	NNS	denotes	panels
T649	376-378	IN	denotes	of
T650	379-384	NN	denotes	speed
T651	385-393	JJ	denotes	congenic
T652	394-401	NNS	denotes	strains
T653	402-406	VBD	denotes	were
T654	417-419	IN	denotes	by
T655	420-433	VBG	denotes	introgressing
T656	434-438	NN	denotes	CAST
T657	439-442	NN	denotes	EiJ
T658	438-439	HYPH	denotes	/
T659	454-461	NNS	denotes	alleles
T660	443-444	-LRB-	denotes	(
T661	444-448	NN	denotes	CAST
T662	448-449	-RRB-	denotes	)
T663	450-453	NN	denotes	QTL
T664	462-466	IN	denotes	onto
T665	467-473	CC	denotes	either
T666	493-495	NN	denotes	hg
T667	474-480	NN	denotes	mutant
T668	481-486	NN	denotes	C57Bl
T669	486-487	HYPH	denotes	/
T670	487-489	NN	denotes	6J
T671	489-490	HYPH	denotes	-
T672	490-492	NN	denotes	hg
T673	492-493	HYPH	denotes	/
T674	536-547	NNS	denotes	backgrounds
T675	496-497	-LRB-	denotes	(
T676	497-499	NN	denotes	HG
T677	499-500	-RRB-	denotes	)
T678	501-503	CC	denotes	or
T679	504-508	JJ	denotes	wild
T680	509-513	NN	denotes	type
T681	514-519	NN	denotes	C57Bl
T682	520-522	NN	denotes	6J
T683	519-520	HYPH	denotes	/
T684	523-524	-LRB-	denotes	(
T685	524-526	NN	denotes	B6
T686	526-527	-RRB-	denotes	)
T687	528-535	JJ	denotes	genetic
T688	547-548	.	denotes	.
T689	548-557	sentence	denotes	Results
T690	550-557	NNS	denotes	Results
T691	557-743	sentence	denotes	The first speed congenic panel was developed by introgressing four overlapping donor regions spanning MMU2 in its entirety onto both HG and B6 backgrounds, for a total of eight strains.
T692	558-561	DT	denotes	The
T693	583-588	NN	denotes	panel
T694	562-567	JJ	denotes	first
T695	568-573	NN	denotes	speed
T696	574-582	JJ	denotes	congenic
T697	593-602	VBN	denotes	developed
T698	589-592	VBD	denotes	was
T699	603-605	IN	denotes	by
T700	606-619	VBG	denotes	introgressing
T701	620-624	CD	denotes	four
T702	643-650	NNS	denotes	regions
T703	625-636	VBG	denotes	overlapping
T704	637-642	NN	denotes	donor
T705	651-659	VBG	denotes	spanning
T706	660-664	NN	denotes	MMU2
T707	665-667	IN	denotes	in
T708	668-671	PRP$	denotes	its
T709	672-680	NN	denotes	entirety
T710	681-685	IN	denotes	onto
T711	686-690	CC	denotes	both
T712	691-693	NN	denotes	HG
T713	701-712	NNS	denotes	backgrounds
T714	694-697	CC	denotes	and
T715	698-700	NN	denotes	B6
T716	712-714	,	denotes	,
T717	714-717	IN	denotes	for
T718	718-719	DT	denotes	a
T719	720-725	NN	denotes	total
T720	726-728	IN	denotes	of
T721	729-734	CD	denotes	eight
T722	735-742	NNS	denotes	strains
T723	742-743	.	denotes	.
T724	743-940	sentence	denotes	Phenotypic characterization of the MMU2 panel confirmed the segregation of multiple growth and obesity QTL and strongly suggested that a subset of these loci modify the effects of the hg deletion.
T725	744-754	JJ	denotes	Phenotypic
T726	755-771	NN	denotes	characterization
T727	790-799	VBD	denotes	confirmed
T728	772-774	IN	denotes	of
T729	775-778	DT	denotes	the
T730	784-789	NN	denotes	panel
T731	779-783	NN	denotes	MMU2
T732	800-803	DT	denotes	the
T733	804-815	NN	denotes	segregation
T734	816-818	IN	denotes	of
T735	819-827	JJ	denotes	multiple
T736	828-834	NN	denotes	growth
T737	847-850	NN	denotes	QTL
T738	835-838	CC	denotes	and
T739	839-846	NN	denotes	obesity
T740	851-854	CC	denotes	and
T741	855-863	RB	denotes	strongly
T742	864-873	VBD	denotes	suggested
T743	874-878	IN	denotes	that
T744	902-908	VBP	denotes	modify
T745	879-880	DT	denotes	a
T746	881-887	NN	denotes	subset
T747	888-890	IN	denotes	of
T748	891-896	DT	denotes	these
T749	897-901	NNS	denotes	loci
T750	909-912	DT	denotes	the
T751	913-920	NNS	denotes	effects
T752	921-923	IN	denotes	of
T753	924-927	DT	denotes	the
T754	931-939	NN	denotes	deletion
T755	928-930	NN	denotes	hg
T756	939-940	.	denotes	.
T757	940-1057	sentence	denotes	The second panel consisted of individual donor regions on an HG background for each QTL on MMU1, 5, 8, 9, 11 and 17.
T758	941-944	DT	denotes	The
T759	952-957	NN	denotes	panel
T760	945-951	JJ	denotes	second
T761	958-967	VBD	denotes	consisted
T762	968-970	IN	denotes	of
T763	971-981	JJ	denotes	individual
T764	988-995	NNS	denotes	regions
T765	982-987	NN	denotes	donor
T766	996-998	IN	denotes	on
T767	999-1001	DT	denotes	an
T768	1005-1015	NN	denotes	background
T769	1002-1004	NN	denotes	HG
T770	1016-1019	IN	denotes	for
T771	1020-1024	DT	denotes	each
T772	1025-1028	NN	denotes	QTL
T773	1029-1031	IN	denotes	on
T774	1032-1035	NN	denotes	MMU
T775	1035-1036	CD	denotes	1
T776	1036-1038	,	denotes	,
T777	1038-1039	CD	denotes	5
T778	1039-1041	,	denotes	,
T779	1041-1042	CD	denotes	8
T780	1042-1044	,	denotes	,
T781	1044-1045	CD	denotes	9
T782	1045-1047	,	denotes	,
T783	1047-1049	CD	denotes	11
T784	1050-1053	CC	denotes	and
T785	1054-1056	CD	denotes	17
T786	1056-1057	.	denotes	.
T787	1057-1212	sentence	denotes	Of the six developed strains, five were successfully characterized and displayed significant differences in growth and/or obesity as compared to controls.
T788	1058-1060	IN	denotes	Of
T789	1111-1124	VBN	denotes	characterized
T790	1061-1064	DT	denotes	the
T791	1079-1086	NNS	denotes	strains
T792	1065-1068	CD	denotes	six
T793	1069-1078	VBN	denotes	developed
T794	1086-1088	,	denotes	,
T795	1088-1092	CD	denotes	five
T796	1093-1097	VBD	denotes	were
T797	1098-1110	RB	denotes	successfully
T798	1125-1128	CC	denotes	and
T799	1129-1138	VBN	denotes	displayed
T800	1139-1150	JJ	denotes	significant
T801	1151-1162	NNS	denotes	differences
T802	1163-1165	IN	denotes	in
T803	1166-1172	NN	denotes	growth
T804	1173-1176	CC	denotes	and
T805	1176-1177	HYPH	denotes	/
T806	1177-1179	CC	denotes	or
T807	1180-1187	NN	denotes	obesity
T808	1188-1190	IN	denotes	as
T809	1191-1199	VBN	denotes	compared
T810	1200-1202	IN	denotes	to
T811	1203-1211	NNS	denotes	controls
T812	1211-1212	.	denotes	.
T813	1212-1392	sentence	denotes	All five displayed phenotypes similar to those originally attributed to each QTL, however, novel phenotypes were unmasked in several of the strains including sex-specific effects.
T814	1213-1216	DT	denotes	All
T815	1217-1221	CD	denotes	five
T816	1222-1231	VBD	denotes	displayed
T817	1326-1334	VBN	denotes	unmasked
T818	1232-1242	NNS	denotes	phenotypes
T819	1243-1250	JJ	denotes	similar
T820	1251-1253	IN	denotes	to
T821	1254-1259	DT	denotes	those
T822	1260-1270	RB	denotes	originally
T823	1271-1281	VBN	denotes	attributed
T824	1282-1284	IN	denotes	to
T825	1285-1289	DT	denotes	each
T826	1290-1293	NN	denotes	QTL
T827	1293-1295	,	denotes	,
T828	1295-1302	RB	denotes	however
T829	1302-1304	,	denotes	,
T830	1304-1309	JJ	denotes	novel
T831	1310-1320	NNS	denotes	phenotypes
T832	1321-1325	VBD	denotes	were
T833	1335-1337	IN	denotes	in
T834	1338-1345	JJ	denotes	several
T835	1346-1348	IN	denotes	of
T836	1349-1352	DT	denotes	the
T837	1353-1360	NNS	denotes	strains
T838	1361-1370	VBG	denotes	including
T839	1371-1374	NN	denotes	sex
T840	1375-1383	JJ	denotes	specific
T841	1374-1375	HYPH	denotes	-
T842	1384-1391	NNS	denotes	effects
T843	1391-1392	.	denotes	.
T844	1392-1404	sentence	denotes	Conclusion
T845	1394-1404	NN	denotes	Conclusion
T846	1404-1602	sentence	denotes	The speed congenic strains developed herein constitute an invaluable genomic resource and provide the foundation to identify the specific nature of genetic variation influencing growth and obesity.
T847	1405-1408	DT	denotes	The
T848	1424-1431	NNS	denotes	strains
T849	1409-1414	NN	denotes	speed
T850	1415-1423	JJ	denotes	congenic
T851	1449-1459	VBP	denotes	constitute
T852	1432-1441	VBN	denotes	developed
T853	1442-1448	RB	denotes	herein
T854	1460-1462	DT	denotes	an
T855	1482-1490	NN	denotes	resource
T856	1463-1473	JJ	denotes	invaluable
T857	1474-1481	JJ	denotes	genomic
T858	1491-1494	CC	denotes	and
T859	1495-1502	VBP	denotes	provide
T860	1503-1506	DT	denotes	the
T861	1507-1517	NN	denotes	foundation
T862	1518-1520	TO	denotes	to
T863	1521-1529	VB	denotes	identify
T864	1530-1533	DT	denotes	the
T865	1543-1549	NN	denotes	nature
T866	1534-1542	JJ	denotes	specific
T867	1550-1552	IN	denotes	of
T868	1553-1560	JJ	denotes	genetic
T869	1561-1570	NN	denotes	variation
T870	1571-1582	VBG	denotes	influencing
T871	1583-1589	NN	denotes	growth
T872	1590-1593	CC	denotes	and
T873	1594-1601	NN	denotes	obesity
T874	1601-1602	.	denotes	.
T2716	1615-1618	DT	denotes	The
T2717	1619-1622	NN	denotes	use
T2718	1643-1651	VBN	denotes	provided
T2719	1623-1625	IN	denotes	of
T2720	1626-1631	NN	denotes	mouse
T2721	1632-1638	NNS	denotes	models
T2722	1639-1642	VBZ	denotes	has
T2723	1652-1660	JJ	denotes	valuable
T2724	1661-1668	NN	denotes	insight
T2725	1669-1673	IN	denotes	into
T2726	1674-1677	DT	denotes	the
T2727	1678-1686	NN	denotes	etiology
T2728	1687-1689	IN	denotes	of
T2729	1690-1699	JJ	denotes	monogenic
T2730	1700-1709	NNS	denotes	syndromes
T2731	1710-1716	VBN	denotes	caused
T2732	1717-1719	IN	denotes	by
T2733	1720-1726	JJ	denotes	single
T2734	1732-1741	NNS	denotes	mutations
T2735	1727-1731	NN	denotes	gene
T2736	1741-1742	.	denotes	.
T2737	1742-1856	sentence	denotes	However, such models do not mimic the genetic complexity of disease traits commonly seen in the human population.
T2738	1743-1750	RB	denotes	However
T2739	1771-1776	VB	denotes	mimic
T2740	1750-1752	,	denotes	,
T2741	1752-1756	JJ	denotes	such
T2742	1757-1763	NNS	denotes	models
T2743	1764-1766	VBP	denotes	do
T2744	1767-1770	RB	denotes	not
T2745	1777-1780	DT	denotes	the
T2746	1789-1799	NN	denotes	complexity
T2747	1781-1788	JJ	denotes	genetic
T2748	1800-1802	IN	denotes	of
T2749	1803-1810	NN	denotes	disease
T2750	1811-1817	NNS	denotes	traits
T2751	1818-1826	RB	denotes	commonly
T2752	1827-1831	VBN	denotes	seen
T2753	1832-1834	IN	denotes	in
T2754	1835-1838	DT	denotes	the
T2755	1845-1855	NN	denotes	population
T2756	1839-1844	JJ	denotes	human
T2757	1855-1856	.	denotes	.
T2758	1856-2091	sentence	denotes	Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.
T2759	1857-1864	NN	denotes	Complex
T2760	1865-1871	NNS	denotes	traits
T2761	1914-1924	VBN	denotes	influenced
T2762	1871-1873	,	denotes	,
T2763	1873-1877	JJ	denotes	such
T2764	1878-1880	IN	denotes	as
T2765	1881-1890	JJ	denotes	polygenic
T2766	1891-1897	NN	denotes	growth
T2767	1898-1901	CC	denotes	and
T2768	1902-1909	NN	denotes	obesity
T2769	1910-1913	VBP	denotes	are
T2770	1925-1927	IN	denotes	by
T2771	1928-1931	DT	denotes	the
T2772	1957-1964	NNS	denotes	effects
T2773	1932-1937	JJ	denotes	small
T2774	1938-1940	IN	denotes	to
T2775	1941-1949	JJ	denotes	moderate
T2776	1950-1956	JJ	denotes	direct
T2777	1965-1967	IN	denotes	of
T2778	1968-1980	JJ	denotes	quantitative
T2779	1987-1991	NNS	denotes	loci
T2780	1981-1986	NN	denotes	trait
T2781	1992-1993	-LRB-	denotes	(
T2782	1993-1996	NN	denotes	QTL
T2783	1996-1997	-RRB-	denotes	)
T2784	1997-1999	,	denotes	,
T2785	1999-2008	NN	denotes	epistasis
T2786	2009-2016	IN	denotes	between
T2787	2017-2020	NN	denotes	QTL
T2788	2021-2028	NNS	denotes	alleles
T2789	2028-2030	,	denotes	,
T2790	2030-2043	JJ	denotes	environmental
T2791	2044-2057	NNS	denotes	perturbations
T2792	2058-2061	CC	denotes	and
T2793	2062-2065	NN	denotes	QTL
T2794	2066-2077	NN	denotes	environment
T2795	2065-2066	HYPH	denotes	-
T2796	2078-2090	NNS	denotes	interactions
T2797	2090-2091	.	denotes	.
T2798	2091-2274	sentence	denotes	To date numerous mouse growth and obesity QTL have been localized [1,2], however, little progress has been made in determining the specific nature of the underlying genetic variants.
T2799	2092-2094	IN	denotes	To
T2800	2148-2157	VBN	denotes	localized
T2801	2095-2099	NN	denotes	date
T2802	2100-2108	JJ	denotes	numerous
T2803	2134-2137	NN	denotes	QTL
T2804	2109-2114	NN	denotes	mouse
T2805	2115-2121	NN	denotes	growth
T2806	2122-2125	CC	denotes	and
T2807	2126-2133	NN	denotes	obesity
T2808	2138-2142	VBP	denotes	have
T2809	2143-2147	VBN	denotes	been
T2810	2199-2203	VBN	denotes	made
T2811	2158-2159	-LRB-	denotes	[
T2812	2161-2162	CD	denotes	2
T2813	2159-2160	CD	denotes	1
T2814	2160-2161	,	denotes	,
T2815	2162-2163	-RRB-	denotes	]
T2816	2163-2165	,	denotes	,
T2817	2165-2172	RB	denotes	however
T2818	2172-2174	,	denotes	,
T2819	2174-2180	JJ	denotes	little
T2820	2181-2189	NN	denotes	progress
T2821	2190-2193	VBZ	denotes	has
T2822	2194-2198	VBN	denotes	been
T2823	2204-2206	IN	denotes	in
T2824	2207-2218	VBG	denotes	determining
T2825	2219-2222	DT	denotes	the
T2826	2232-2238	NN	denotes	nature
T2827	2223-2231	JJ	denotes	specific
T2828	2239-2241	IN	denotes	of
T2829	2242-2245	DT	denotes	the
T2830	2265-2273	NNS	denotes	variants
T2831	2246-2256	VBG	denotes	underlying
T2832	2257-2264	JJ	denotes	genetic
T2833	2273-2274	.	denotes	.
T2834	2274-2423	sentence	denotes	One resource used to fine map QTL are congenic strains which are designed to convert a complex polygenic trait into one that is mono- or oligogenic.
T2835	2275-2278	CD	denotes	One
T2836	2279-2287	NN	denotes	resource
T2837	2309-2312	VBP	denotes	are
T2838	2288-2292	VBN	denotes	used
T2839	2293-2295	TO	denotes	to
T2840	2301-2304	VB	denotes	map
T2841	2296-2300	RB	denotes	fine
T2842	2305-2308	NN	denotes	QTL
T2843	2313-2321	JJ	denotes	congenic
T2844	2322-2329	NNS	denotes	strains
T2845	2330-2335	WDT	denotes	which
T2846	2340-2348	VBN	denotes	designed
T2847	2336-2339	VBP	denotes	are
T2848	2349-2351	TO	denotes	to
T2849	2352-2359	VB	denotes	convert
T2850	2360-2361	DT	denotes	a
T2851	2380-2385	NN	denotes	trait
T2852	2362-2369	JJ	denotes	complex
T2853	2370-2379	JJ	denotes	polygenic
T2854	2386-2390	IN	denotes	into
T2855	2391-2394	CD	denotes	one
T2856	2395-2399	WDT	denotes	that
T2857	2400-2402	VBZ	denotes	is
T2858	2403-2407	AFX	denotes	mono
T2859	2412-2422	JJ	denotes	oligogenic
T2860	2407-2408	HYPH	denotes	-
T2861	2409-2411	CC	denotes	or
T2862	2422-2423	.	denotes	.
T2863	2423-2643	sentence	denotes	This is accomplished by eliminating segregating genetic variation outside the locus of interest and reducing the environmental variation influencing a trait by characterizing large numbers of genetically identical mice.
T2864	2424-2428	DT	denotes	This
T2865	2432-2444	VBN	denotes	accomplished
T2866	2429-2431	VBZ	denotes	is
T2867	2445-2447	IN	denotes	by
T2868	2448-2459	VBG	denotes	eliminating
T2869	2460-2471	VBG	denotes	segregating
T2870	2472-2479	JJ	denotes	genetic
T2871	2480-2489	NN	denotes	variation
T2872	2490-2497	IN	denotes	outside
T2873	2498-2501	DT	denotes	the
T2874	2502-2507	NN	denotes	locus
T2875	2508-2510	IN	denotes	of
T2876	2511-2519	NN	denotes	interest
T2877	2520-2523	CC	denotes	and
T2878	2524-2532	VBG	denotes	reducing
T2879	2533-2536	DT	denotes	the
T2880	2551-2560	NN	denotes	variation
T2881	2537-2550	JJ	denotes	environmental
T2882	2561-2572	VBG	denotes	influencing
T2883	2573-2574	DT	denotes	a
T2884	2575-2580	NN	denotes	trait
T2885	2581-2583	IN	denotes	by
T2886	2584-2598	VBG	denotes	characterizing
T2887	2599-2604	JJ	denotes	large
T2888	2605-2612	NNS	denotes	numbers
T2889	2613-2615	IN	denotes	of
T2890	2616-2627	RB	denotes	genetically
T2891	2628-2637	JJ	denotes	identical
T2892	2638-2642	NNS	denotes	mice
T2893	2642-2643	.	denotes	.
T2894	2643-2772	sentence	denotes	The Complex Trait Consortium (CTC) considers congenic analysis an excellent method to confirm and subsequently fine map QTL [3].
T2895	2644-2647	DT	denotes	The
T2896	2662-2672	NNP	denotes	Consortium
T2897	2648-2655	NNP	denotes	Complex
T2898	2656-2661	NNP	denotes	Trait
T2899	2679-2688	VBZ	denotes	considers
T2900	2673-2674	-LRB-	denotes	(
T2901	2674-2677	NNP	denotes	CTC
T2902	2677-2678	-RRB-	denotes	)
T2903	2689-2697	JJ	denotes	congenic
T2904	2698-2706	NN	denotes	analysis
T2905	2720-2726	NN	denotes	method
T2906	2707-2709	DT	denotes	an
T2907	2710-2719	JJ	denotes	excellent
T2908	2727-2729	TO	denotes	to
T2909	2730-2737	VB	denotes	confirm
T2910	2738-2741	CC	denotes	and
T2911	2742-2754	RB	denotes	subsequently
T2912	2760-2763	VB	denotes	map
T2913	2755-2759	RB	denotes	fine
T2914	2764-2767	NN	denotes	QTL
T2915	2768-2769	-LRB-	denotes	[
T2916	2769-2770	CD	denotes	3
T2917	2770-2771	-RRB-	denotes	]
T2918	2771-2772	.	denotes	.
T2919	2772-2989	sentence	denotes	Traditionally, congenic strains are developed by introgressing QTL alleles from a donor strain, whose boundaries are defined by genetic markers, on the genetic background of a recipient strain via 10 backcrosses [4].
T2920	2773-2786	RB	denotes	Traditionally
T2921	2809-2818	VBN	denotes	developed
T2922	2786-2788	,	denotes	,
T2923	2788-2796	JJ	denotes	congenic
T2924	2797-2804	NNS	denotes	strains
T2925	2805-2808	VBP	denotes	are
T2926	2819-2821	IN	denotes	by
T2927	2822-2835	VBG	denotes	introgressing
T2928	2836-2839	NN	denotes	QTL
T2929	2840-2847	NNS	denotes	alleles
T2930	2848-2852	IN	denotes	from
T2931	2853-2854	DT	denotes	a
T2932	2861-2867	NN	denotes	strain
T2933	2855-2860	NN	denotes	donor
T2934	2867-2869	,	denotes	,
T2935	2869-2874	WP$	denotes	whose
T2936	2875-2885	NNS	denotes	boundaries
T2937	2890-2897	VBN	denotes	defined
T2938	2886-2889	VBP	denotes	are
T2939	2898-2900	IN	denotes	by
T2940	2901-2908	JJ	denotes	genetic
T2941	2909-2916	NNS	denotes	markers
T2942	2916-2918	,	denotes	,
T2943	2918-2920	IN	denotes	on
T2944	2921-2924	DT	denotes	the
T2945	2933-2943	NN	denotes	background
T2946	2925-2932	JJ	denotes	genetic
T2947	2944-2946	IN	denotes	of
T2948	2947-2948	DT	denotes	a
T2949	2959-2965	NN	denotes	strain
T2950	2949-2958	NN	denotes	recipient
T2951	2966-2969	IN	denotes	via
T2952	2970-2972	CD	denotes	10
T2953	2973-2984	NNS	denotes	backcrosses
T2954	2985-2986	-LRB-	denotes	[
T2955	2986-2987	CD	denotes	4
T2956	2987-2988	-RRB-	denotes	]
T2957	2988-2989	.	denotes	.
T2958	2989-3111	sentence	denotes	While technically straightforward this is a time consuming endeavor taking over three years to construct a single strain.
T2959	2990-2995	IN	denotes	While
T2960	3008-3023	JJ	denotes	straightforward
T2961	2996-3007	RB	denotes	technically
T2962	3029-3031	VBZ	denotes	is
T2963	3024-3028	NN	denotes	this
T2964	3032-3033	DT	denotes	a
T2965	3049-3057	NN	denotes	endeavor
T2966	3034-3038	NN	denotes	time
T2967	3039-3048	VBG	denotes	consuming
T2968	3058-3064	VBG	denotes	taking
T2969	3065-3069	IN	denotes	over
T2970	3070-3075	CD	denotes	three
T2971	3076-3081	NNS	denotes	years
T2972	3082-3084	TO	denotes	to
T2973	3085-3094	VB	denotes	construct
T2974	3095-3096	DT	denotes	a
T2975	3104-3110	NN	denotes	strain
T2976	3097-3103	JJ	denotes	single
T2977	3110-3111	.	denotes	.
T2978	3111-3254	sentence	denotes	The speed congenic approach is an alternative to this lengthy process and can reduce the number of required backcrosses from 10 to five [5,6].
T2979	3112-3115	DT	denotes	The
T2980	3131-3139	NN	denotes	approach
T2981	3116-3121	NN	denotes	speed
T2982	3122-3130	JJ	denotes	congenic
T2983	3140-3142	VBZ	denotes	is
T2984	3143-3145	DT	denotes	an
T2985	3146-3157	NN	denotes	alternative
T2986	3158-3160	IN	denotes	to
T2987	3161-3165	DT	denotes	this
T2988	3174-3181	NN	denotes	process
T2989	3166-3173	JJ	denotes	lengthy
T2990	3182-3185	CC	denotes	and
T2991	3186-3189	MD	denotes	can
T2992	3190-3196	VB	denotes	reduce
T2993	3197-3200	DT	denotes	the
T2994	3201-3207	NN	denotes	number
T2995	3208-3210	IN	denotes	of
T2996	3211-3219	VBN	denotes	required
T2997	3220-3231	NNS	denotes	backcrosses
T2998	3232-3236	IN	denotes	from
T2999	3237-3239	CD	denotes	10
T3000	3240-3242	IN	denotes	to
T3001	3243-3247	CD	denotes	five
T3002	3248-3249	-LRB-	denotes	[
T3003	3251-3252	CD	denotes	6
T3004	3249-3250	CD	denotes	5
T3005	3250-3251	,	denotes	,
T3006	3252-3253	-RRB-	denotes	]
T3007	3253-3254	.	denotes	.
T3008	3254-3402	sentence	denotes	This strategy uses marker-assisted selection to identify male mice inheriting fewer donor alleles, than expected on average, during each backcross.
T3009	3255-3259	DT	denotes	This
T3010	3260-3268	NN	denotes	strategy
T3011	3269-3273	VBZ	denotes	uses
T3012	3274-3280	NN	denotes	marker
T3013	3281-3289	VBN	denotes	assisted
T3014	3280-3281	HYPH	denotes	-
T3015	3290-3299	NN	denotes	selection
T3016	3300-3302	TO	denotes	to
T3017	3303-3311	VB	denotes	identify
T3018	3312-3316	JJ	denotes	male
T3019	3317-3321	NNS	denotes	mice
T3020	3322-3332	VBG	denotes	inheriting
T3021	3333-3338	JJR	denotes	fewer
T3022	3345-3352	NNS	denotes	alleles
T3023	3339-3344	NN	denotes	donor
T3024	3352-3354	,	denotes	,
T3025	3354-3358	IN	denotes	than
T3026	3359-3367	VBN	denotes	expected
T3027	3368-3370	IN	denotes	on
T3028	3371-3378	JJ	denotes	average
T3029	3378-3380	,	denotes	,
T3030	3380-3386	IN	denotes	during
T3031	3387-3391	DT	denotes	each
T3032	3392-3401	NN	denotes	backcross
T3033	3401-3402	.	denotes	.
T3034	3402-3569	sentence	denotes	Numerous traditionally developed and speed congenics have been used to successfully isolate mouse QTL for a wide array of traits, including growth and obesity [7-13].
T3035	3403-3411	JJ	denotes	Numerous
T3036	3446-3455	NNS	denotes	congenics
T3037	3412-3425	RB	denotes	traditionally
T3038	3426-3435	VBN	denotes	developed
T3039	3436-3439	CC	denotes	and
T3040	3440-3445	NN	denotes	speed
T3041	3466-3470	VBN	denotes	used
T3042	3456-3460	VBP	denotes	have
T3043	3461-3465	VBN	denotes	been
T3044	3471-3473	TO	denotes	to
T3045	3487-3494	VB	denotes	isolate
T3046	3474-3486	RB	denotes	successfully
T3047	3495-3500	NN	denotes	mouse
T3048	3501-3504	NN	denotes	QTL
T3049	3505-3508	IN	denotes	for
T3050	3509-3510	DT	denotes	a
T3051	3516-3521	NN	denotes	array
T3052	3511-3515	JJ	denotes	wide
T3053	3522-3524	IN	denotes	of
T3054	3525-3531	NNS	denotes	traits
T3055	3531-3533	,	denotes	,
T3056	3533-3542	VBG	denotes	including
T3057	3543-3549	NN	denotes	growth
T3058	3550-3553	CC	denotes	and
T3059	3554-3561	NN	denotes	obesity
T3060	3562-3563	-LRB-	denotes	[
T3061	3563-3564	CD	denotes	7
T3062	3564-3565	SYM	denotes	-
T3063	3565-3567	CD	denotes	13
T3064	3567-3568	-RRB-	denotes	]
T3065	3568-3569	.	denotes	.
T3066	3569-3773	sentence	denotes	The C57Bl/6J-hg/hg (HG) mouse is a model of systemic overgrowth resulting from a spontaneous deletion on MMU10, which eliminates expression of the Socs2 (suppressor of cytokine signaling 2) gene [14-16].
T3067	3570-3573	DT	denotes	The
T3068	3594-3599	NN	denotes	mouse
T3069	3574-3579	NN	denotes	C57Bl
T3070	3586-3588	NN	denotes	hg
T3071	3579-3580	HYPH	denotes	/
T3072	3580-3582	NN	denotes	6J
T3073	3582-3583	HYPH	denotes	-
T3074	3583-3585	NN	denotes	hg
T3075	3585-3586	HYPH	denotes	/
T3076	3589-3590	-LRB-	denotes	(
T3077	3590-3592	NN	denotes	HG
T3078	3592-3593	-RRB-	denotes	)
T3079	3600-3602	VBZ	denotes	is
T3080	3603-3604	DT	denotes	a
T3081	3605-3610	NN	denotes	model
T3082	3611-3613	IN	denotes	of
T3083	3614-3622	JJ	denotes	systemic
T3084	3623-3633	NN	denotes	overgrowth
T3085	3634-3643	VBG	denotes	resulting
T3086	3644-3648	IN	denotes	from
T3087	3649-3650	DT	denotes	a
T3088	3663-3671	NN	denotes	deletion
T3089	3651-3662	JJ	denotes	spontaneous
T3090	3672-3674	IN	denotes	on
T3091	3675-3680	NN	denotes	MMU10
T3092	3680-3682	,	denotes	,
T3093	3682-3687	WDT	denotes	which
T3094	3688-3698	VBZ	denotes	eliminates
T3095	3699-3709	NN	denotes	expression
T3096	3710-3712	IN	denotes	of
T3097	3713-3716	DT	denotes	the
T3098	3760-3764	NN	denotes	gene
T3099	3717-3722	NN	denotes	Socs2
T3100	3723-3724	-LRB-	denotes	(
T3101	3724-3734	NN	denotes	suppressor
T3102	3735-3737	IN	denotes	of
T3103	3738-3746	NN	denotes	cytokine
T3104	3747-3756	NN	denotes	signaling
T3105	3757-3758	CD	denotes	2
T3106	3758-3759	-RRB-	denotes	)
T3107	3765-3766	-LRB-	denotes	[
T3108	3766-3768	CD	denotes	14
T3109	3768-3769	SYM	denotes	-
T3110	3769-3771	CD	denotes	16
T3111	3771-3772	-RRB-	denotes	]
T3112	3772-3773	.	denotes	.
T3113	3773-3961	sentence	denotes	The role of Socs2 in the HG phenotype was confirmed by an independently engineered Socs2-/- knockout mouse which shared a number of phenotypes in common with HG, including gigantism [17].
T3114	3774-3777	DT	denotes	The
T3115	3778-3782	NN	denotes	role
T3116	3816-3825	VBN	denotes	confirmed
T3117	3783-3785	IN	denotes	of
T3118	3786-3791	NN	denotes	Socs2
T3119	3792-3794	IN	denotes	in
T3120	3795-3798	DT	denotes	the
T3121	3802-3811	NN	denotes	phenotype
T3122	3799-3801	NN	denotes	HG
T3123	3812-3815	VBD	denotes	was
T3124	3826-3828	IN	denotes	by
T3125	3829-3831	DT	denotes	an
T3126	3875-3880	NN	denotes	mouse
T3127	3832-3845	RB	denotes	independently
T3128	3846-3856	VBN	denotes	engineered
T3129	3857-3862	NN	denotes	Socs2
T3130	3866-3874	NN	denotes	knockout
T3131	3862-3863	SYM	denotes	-
T3132	3863-3864	HYPH	denotes	/
T3133	3864-3865	SYM	denotes	-
T3134	3881-3886	WDT	denotes	which
T3135	3887-3893	VBD	denotes	shared
T3136	3894-3895	DT	denotes	a
T3137	3896-3902	NN	denotes	number
T3138	3903-3905	IN	denotes	of
T3139	3906-3916	NNS	denotes	phenotypes
T3140	3917-3919	IN	denotes	in
T3141	3920-3926	NN	denotes	common
T3142	3927-3931	IN	denotes	with
T3143	3932-3934	NN	denotes	HG
T3144	3934-3936	,	denotes	,
T3145	3936-3945	VBG	denotes	including
T3146	3946-3955	NN	denotes	gigantism
T3147	3956-3957	-LRB-	denotes	[
T3148	3957-3959	CD	denotes	17
T3149	3959-3960	-RRB-	denotes	]
T3150	3960-3961	.	denotes	.
T3151	3961-4055	sentence	denotes	QTL which alter the phenotypic effects of another locus are referred to as modifier QTL [18].
T3152	3962-3965	NN	denotes	QTL
T3153	4022-4030	VBN	denotes	referred
T3154	3966-3971	WDT	denotes	which
T3155	3972-3977	VBP	denotes	alter
T3156	3978-3981	DT	denotes	the
T3157	3993-4000	NNS	denotes	effects
T3158	3982-3992	JJ	denotes	phenotypic
T3159	4001-4003	IN	denotes	of
T3160	4004-4011	DT	denotes	another
T3161	4012-4017	NN	denotes	locus
T3162	4018-4021	VBP	denotes	are
T3163	4031-4033	IN	denotes	to
T3164	4034-4036	IN	denotes	as
T3165	4037-4045	NN	denotes	modifier
T3166	4046-4049	NN	denotes	QTL
T3167	4050-4051	-LRB-	denotes	[
T3168	4051-4053	CD	denotes	18
T3169	4053-4054	-RRB-	denotes	]
T3170	4054-4055	.	denotes	.
T3171	4055-4282	sentence	denotes	Modifier QTL have been mapped for numerous traits and in these studies the modified locus is typically a known gene containing a spontaneously arisen or engineered mutation with major phenotypic effects, such as hg [11,19-21].
T3172	4056-4064	NN	denotes	Modifier
T3173	4065-4068	NN	denotes	QTL
T3174	4079-4085	VBN	denotes	mapped
T3175	4069-4073	VBP	denotes	have
T3176	4074-4078	VBN	denotes	been
T3177	4086-4089	IN	denotes	for
T3178	4090-4098	JJ	denotes	numerous
T3179	4099-4105	NNS	denotes	traits
T3180	4106-4109	CC	denotes	and
T3181	4110-4112	IN	denotes	in
T3182	4146-4148	VBZ	denotes	is
T3183	4113-4118	DT	denotes	these
T3184	4119-4126	NNS	denotes	studies
T3185	4127-4130	DT	denotes	the
T3186	4140-4145	NN	denotes	locus
T3187	4131-4139	VBN	denotes	modified
T3188	4149-4158	RB	denotes	typically
T3189	4159-4160	DT	denotes	a
T3190	4167-4171	NN	denotes	gene
T3191	4161-4166	VBN	denotes	known
T3192	4172-4182	VBG	denotes	containing
T3193	4183-4184	DT	denotes	a
T3194	4220-4228	NN	denotes	mutation
T3195	4185-4198	RB	denotes	spontaneously
T3196	4199-4205	VBN	denotes	arisen
T3197	4206-4208	CC	denotes	or
T3198	4209-4219	VBN	denotes	engineered
T3199	4229-4233	IN	denotes	with
T3200	4234-4239	JJ	denotes	major
T3201	4251-4258	NNS	denotes	effects
T3202	4240-4250	JJ	denotes	phenotypic
T3203	4258-4260	,	denotes	,
T3204	4260-4264	JJ	denotes	such
T3205	4265-4267	IN	denotes	as
T3206	4268-4270	NN	denotes	hg
T3207	4271-4272	-LRB-	denotes	[
T3208	4272-4274	CD	denotes	11
T3209	4274-4275	,	denotes	,
T3210	4275-4277	CD	denotes	19
T3211	4277-4278	SYM	denotes	-
T3212	4278-4280	CD	denotes	21
T3213	4280-4281	-RRB-	denotes	]
T3214	4281-4282	.	denotes	.
T3215	4282-4436	sentence	denotes	Epistasis forms the basis of these interactions, implying that the known gene and its modifiers are members of the same biochemical or metabolic pathway.
T3216	4283-4292	NN	denotes	Epistasis
T3217	4293-4298	VBZ	denotes	forms
T3218	4299-4302	DT	denotes	the
T3219	4303-4308	NN	denotes	basis
T3220	4309-4311	IN	denotes	of
T3221	4312-4317	DT	denotes	these
T3222	4318-4330	NNS	denotes	interactions
T3223	4330-4332	,	denotes	,
T3224	4332-4340	VBG	denotes	implying
T3225	4341-4345	IN	denotes	that
T3226	4379-4382	VBP	denotes	are
T3227	4346-4349	DT	denotes	the
T3228	4356-4360	NN	denotes	gene
T3229	4350-4355	VBN	denotes	known
T3230	4361-4364	CC	denotes	and
T3231	4365-4368	PRP$	denotes	its
T3232	4369-4378	NNS	denotes	modifiers
T3233	4383-4390	NNS	denotes	members
T3234	4391-4393	IN	denotes	of
T3235	4394-4397	DT	denotes	the
T3236	4428-4435	NN	denotes	pathway
T3237	4398-4402	JJ	denotes	same
T3238	4403-4414	JJ	denotes	biochemical
T3239	4415-4417	CC	denotes	or
T3240	4418-4427	JJ	denotes	metabolic
T3241	4435-4436	.	denotes	.
T3242	4436-4536	sentence	denotes	Different genetic backgrounds have been shown to modify the growth-enhancing effects of hg [15,22].
T3243	4437-4446	JJ	denotes	Different
T3244	4455-4466	NNS	denotes	backgrounds
T3245	4447-4454	JJ	denotes	genetic
T3246	4477-4482	VBN	denotes	shown
T3247	4467-4471	VBP	denotes	have
T3248	4472-4476	VBN	denotes	been
T3249	4483-4485	TO	denotes	to
T3250	4486-4492	VB	denotes	modify
T3251	4493-4496	DT	denotes	the
T3252	4514-4521	NNS	denotes	effects
T3253	4497-4503	NN	denotes	growth
T3254	4504-4513	VBG	denotes	enhancing
T3255	4503-4504	HYPH	denotes	-
T3256	4522-4524	IN	denotes	of
T3257	4525-4527	NN	denotes	hg
T3258	4528-4529	-LRB-	denotes	[
T3259	4532-4534	CD	denotes	22
T3260	4529-4531	CD	denotes	15
T3261	4531-4532	,	denotes	,
T3262	4534-4535	-RRB-	denotes	]
T3263	4535-4536	.	denotes	.
T3264	4536-4763	sentence	denotes	Since the primary function of Socs2 is to negatively regulate growth hormone (Gh) [23], it is likely these background effects are the result of polymorphism influencing interactions between members of the Gh signaling pathway.
T3265	4537-4542	IN	denotes	Since
T3266	4573-4575	VBZ	denotes	is
T3267	4543-4546	DT	denotes	the
T3268	4555-4563	NN	denotes	function
T3269	4547-4554	JJ	denotes	primary
T3270	4564-4566	IN	denotes	of
T3271	4567-4572	NN	denotes	Socs2
T3272	4628-4630	VBZ	denotes	is
T3273	4576-4578	TO	denotes	to
T3274	4590-4598	VB	denotes	regulate
T3275	4579-4589	RB	denotes	negatively
T3276	4599-4605	NN	denotes	growth
T3277	4606-4613	NN	denotes	hormone
T3278	4614-4615	-LRB-	denotes	(
T3279	4615-4617	NN	denotes	Gh
T3280	4617-4618	-RRB-	denotes	)
T3281	4619-4620	-LRB-	denotes	[
T3282	4620-4622	CD	denotes	23
T3283	4622-4623	-RRB-	denotes	]
T3284	4623-4625	,	denotes	,
T3285	4625-4627	PRP	denotes	it
T3286	4631-4637	JJ	denotes	likely
T3287	4638-4643	DT	denotes	these
T3288	4655-4662	NNS	denotes	effects
T3289	4644-4654	NN	denotes	background
T3290	4663-4666	VBP	denotes	are
T3291	4667-4670	DT	denotes	the
T3292	4671-4677	NN	denotes	result
T3293	4678-4680	IN	denotes	of
T3294	4681-4693	NN	denotes	polymorphism
T3295	4694-4705	VBG	denotes	influencing
T3296	4706-4718	NNS	denotes	interactions
T3297	4719-4726	IN	denotes	between
T3298	4727-4734	NNS	denotes	members
T3299	4735-4737	IN	denotes	of
T3300	4738-4741	DT	denotes	the
T3301	4755-4762	NN	denotes	pathway
T3302	4742-4744	NN	denotes	Gh
T3303	4745-4754	NN	denotes	signaling
T3304	4762-4763	.	denotes	.
T3305	4763-4932	sentence	denotes	Thus, identification of hg modifiers has the potential to uncover novel members of metabolically important pathways or previously unknown convergences between pathways.
T3306	4764-4768	RB	denotes	Thus
T3307	4801-4804	VBZ	denotes	has
T3308	4768-4770	,	denotes	,
T3309	4770-4784	NN	denotes	identification
T3310	4785-4787	IN	denotes	of
T3311	4788-4790	NN	denotes	hg
T3312	4791-4800	NNS	denotes	modifiers
T3313	4805-4808	DT	denotes	the
T3314	4809-4818	NN	denotes	potential
T3315	4819-4821	TO	denotes	to
T3316	4822-4829	VB	denotes	uncover
T3317	4830-4835	JJ	denotes	novel
T3318	4836-4843	NNS	denotes	members
T3319	4844-4846	IN	denotes	of
T3320	4847-4860	RB	denotes	metabolically
T3321	4861-4870	JJ	denotes	important
T3322	4871-4879	NNS	denotes	pathways
T3323	4880-4882	CC	denotes	or
T3324	4883-4893	RB	denotes	previously
T3325	4894-4901	JJ	denotes	unknown
T3326	4902-4914	NNS	denotes	convergences
T3327	4915-4922	IN	denotes	between
T3328	4923-4931	NNS	denotes	pathways
T3329	4931-4932	.	denotes	.
T3330	4932-5051	sentence	denotes	As an initial step, growth and carcass composition QTL were identified in a cross between CAST/EiJ (CAST) and HG [24].
T3331	4933-4935	IN	denotes	As
T3332	4993-5003	VBN	denotes	identified
T3333	4936-4938	DT	denotes	an
T3334	4947-4951	NN	denotes	step
T3335	4939-4946	JJ	denotes	initial
T3336	4951-4953	,	denotes	,
T3337	4953-4959	NN	denotes	growth
T3338	4984-4987	NN	denotes	QTL
T3339	4960-4963	CC	denotes	and
T3340	4964-4971	NN	denotes	carcass
T3341	4972-4983	NN	denotes	composition
T3342	4988-4992	VBD	denotes	were
T3343	5004-5006	IN	denotes	in
T3344	5007-5008	DT	denotes	a
T3345	5009-5014	NN	denotes	cross
T3346	5015-5022	IN	denotes	between
T3347	5023-5027	NN	denotes	CAST
T3348	5028-5031	NN	denotes	EiJ
T3349	5027-5028	HYPH	denotes	/
T3350	5032-5033	-LRB-	denotes	(
T3351	5033-5037	NN	denotes	CAST
T3352	5037-5038	-RRB-	denotes	)
T3353	5039-5042	CC	denotes	and
T3354	5043-5045	NN	denotes	HG
T3355	5046-5047	-LRB-	denotes	[
T3356	5047-5049	CD	denotes	24
T3357	5049-5050	-RRB-	denotes	]
T3358	5050-5051	.	denotes	.
T3359	5051-5290	sentence	denotes	In the F2, mice homozygous for the hg deletion (hg/hg) and wild type (+/+) were assayed and hg modifier QTL were defined as those either absent in +/+ mice and segregating in hg/hg or loci with altered gene action dependent on background.
T3360	5052-5054	IN	denotes	In
T3361	5132-5139	VBN	denotes	assayed
T3362	5055-5058	DT	denotes	the
T3363	5059-5061	NN	denotes	F2
T3364	5061-5063	,	denotes	,
T3365	5063-5067	NNS	denotes	mice
T3366	5068-5078	JJ	denotes	homozygous
T3367	5079-5082	IN	denotes	for
T3368	5083-5086	DT	denotes	the
T3369	5090-5098	NN	denotes	deletion
T3370	5087-5089	NN	denotes	hg
T3371	5099-5100	-LRB-	denotes	(
T3372	5103-5105	NN	denotes	hg
T3373	5100-5102	NN	denotes	hg
T3374	5102-5103	HYPH	denotes	/
T3375	5105-5106	-RRB-	denotes	)
T3376	5107-5110	CC	denotes	and
T3377	5111-5115	JJ	denotes	wild
T3378	5116-5120	NN	denotes	type
T3379	5121-5122	-LRB-	denotes	(
T3380	5122-5123	SYM	denotes	+
T3381	5124-5125	SYM	denotes	+
T3382	5123-5124	HYPH	denotes	/
T3383	5125-5126	-RRB-	denotes	)
T3384	5127-5131	VBD	denotes	were
T3385	5140-5143	CC	denotes	and
T3386	5144-5146	NN	denotes	hg
T3387	5147-5155	NN	denotes	modifier
T3388	5156-5159	NN	denotes	QTL
T3389	5165-5172	VBN	denotes	defined
T3390	5160-5164	VBD	denotes	were
T3391	5173-5175	IN	denotes	as
T3392	5176-5181	DT	denotes	those
T3393	5182-5188	CC	denotes	either
T3394	5189-5195	JJ	denotes	absent
T3395	5196-5198	IN	denotes	in
T3396	5199-5200	SYM	denotes	+
T3397	5201-5202	SYM	denotes	+
T3398	5200-5201	HYPH	denotes	/
T3399	5203-5207	NNS	denotes	mice
T3400	5208-5211	CC	denotes	and
T3401	5212-5223	VBG	denotes	segregating
T3402	5224-5226	IN	denotes	in
T3403	5227-5229	NN	denotes	hg
T3404	5230-5232	NN	denotes	hg
T3405	5229-5230	HYPH	denotes	/
T3406	5233-5235	CC	denotes	or
T3407	5236-5240	NNS	denotes	loci
T3408	5241-5245	IN	denotes	with
T3409	5246-5253	VBN	denotes	altered
T3410	5259-5265	NN	denotes	action
T3411	5254-5258	NN	denotes	gene
T3412	5266-5275	JJ	denotes	dependent
T3413	5276-5278	IN	denotes	on
T3414	5279-5289	NN	denotes	background
T3415	5289-5290	.	denotes	.
T3416	5290-5693	sentence	denotes	Four hg modifier QTL (Wg2 on MMU2, Carfhg2 on MMU9, Carp2 on MMU11 and Feml3 on MMU17) were identified, along with 12 additional QTL (Q1Ucd1 on MMU1 (which only reached a suggestive level of statistical significance), Wg1, Carp1, Cara1 and Feml1 on MMU2, Carfhg1 on MMU5, Wg3 on MMU8, Feml2 on MMU9, Wg4 and Cara2 on MMU11 and Carp3 and Cara3 on MMU17) whose expression was independent of the hg locus.
T3417	5291-5295	CD	denotes	Four
T3418	5296-5298	NN	denotes	hg
T3419	5308-5311	NN	denotes	QTL
T3420	5299-5307	NN	denotes	modifier
T3421	5383-5393	VBN	denotes	identified
T3422	5312-5313	-LRB-	denotes	(
T3423	5313-5316	NN	denotes	Wg2
T3424	5317-5319	IN	denotes	on
T3425	5320-5324	NN	denotes	MMU2
T3426	5324-5326	,	denotes	,
T3427	5326-5333	NN	denotes	Carfhg2
T3428	5334-5336	IN	denotes	on
T3429	5337-5341	NN	denotes	MMU9
T3430	5341-5343	,	denotes	,
T3431	5343-5348	NN	denotes	Carp2
T3432	5349-5351	IN	denotes	on
T3433	5352-5357	NN	denotes	MMU11
T3434	5358-5361	CC	denotes	and
T3435	5362-5367	NN	denotes	Feml3
T3436	5368-5370	IN	denotes	on
T3437	5371-5376	NN	denotes	MMU17
T3438	5376-5377	-RRB-	denotes	)
T3439	5378-5382	VBD	denotes	were
T3440	5393-5395	,	denotes	,
T3441	5395-5400	IN	denotes	along
T3442	5401-5405	IN	denotes	with
T3443	5406-5408	CD	denotes	12
T3444	5420-5423	NN	denotes	QTL
T3445	5409-5419	JJ	denotes	additional
T3446	5424-5425	-LRB-	denotes	(
T3447	5425-5431	NN	denotes	Q1Ucd1
T3448	5432-5434	IN	denotes	on
T3449	5435-5439	NN	denotes	MMU1
T3450	5440-5441	-LRB-	denotes	(
T3451	5441-5446	WDT	denotes	which
T3452	5452-5459	VBD	denotes	reached
T3453	5447-5451	RB	denotes	only
T3454	5460-5461	DT	denotes	a
T3455	5473-5478	NN	denotes	level
T3456	5462-5472	JJ	denotes	suggestive
T3457	5479-5481	IN	denotes	of
T3458	5482-5493	JJ	denotes	statistical
T3459	5494-5506	NN	denotes	significance
T3460	5506-5507	-RRB-	denotes	)
T3461	5507-5509	,	denotes	,
T3462	5509-5512	NN	denotes	Wg1
T3463	5512-5514	,	denotes	,
T3464	5514-5519	NN	denotes	Carp1
T3465	5519-5521	,	denotes	,
T3466	5521-5526	NN	denotes	Cara1
T3467	5527-5530	CC	denotes	and
T3468	5531-5536	NN	denotes	Feml1
T3469	5537-5539	IN	denotes	on
T3470	5540-5544	NN	denotes	MMU2
T3471	5544-5546	,	denotes	,
T3472	5546-5553	NN	denotes	Carfhg1
T3473	5554-5556	IN	denotes	on
T3474	5557-5561	NN	denotes	MMU5
T3475	5561-5563	,	denotes	,
T3476	5563-5566	NN	denotes	Wg3
T3477	5567-5569	IN	denotes	on
T3478	5570-5574	NN	denotes	MMU8
T3479	5574-5576	,	denotes	,
T3480	5576-5581	NN	denotes	Feml2
T3481	5582-5584	IN	denotes	on
T3482	5585-5589	NN	denotes	MMU9
T3483	5589-5591	,	denotes	,
T3484	5591-5594	NN	denotes	Wg4
T3485	5595-5598	CC	denotes	and
T3486	5599-5604	NN	denotes	Cara2
T3487	5605-5607	IN	denotes	on
T3488	5608-5613	NN	denotes	MMU11
T3489	5614-5617	CC	denotes	and
T3490	5618-5623	NN	denotes	Carp3
T3491	5624-5627	CC	denotes	and
T3492	5628-5633	NN	denotes	Cara3
T3493	5634-5636	IN	denotes	on
T3494	5637-5642	NN	denotes	MMU17
T3495	5642-5643	-RRB-	denotes	)
T3496	5644-5649	WP$	denotes	whose
T3497	5650-5660	NN	denotes	expression
T3498	5661-5664	VBD	denotes	was
T3499	5665-5676	JJ	denotes	independent
T3500	5677-5679	IN	denotes	of
T3501	5680-5683	DT	denotes	the
T3502	5687-5692	NN	denotes	locus
T3503	5684-5686	NN	denotes	hg
T3504	5692-5693	.	denotes	.
T3505	5693-5794	sentence	denotes	In the current study we have developed speed congenic strains to isolate all the aforementioned QTL.
T3506	5694-5696	IN	denotes	In
T3507	5723-5732	VBN	denotes	developed
T3508	5697-5700	DT	denotes	the
T3509	5709-5714	NN	denotes	study
T3510	5701-5708	JJ	denotes	current
T3511	5715-5717	PRP	denotes	we
T3512	5718-5722	VBP	denotes	have
T3513	5733-5738	NN	denotes	speed
T3514	5739-5747	JJ	denotes	congenic
T3515	5748-5755	NNS	denotes	strains
T3516	5756-5758	TO	denotes	to
T3517	5759-5766	VB	denotes	isolate
T3518	5767-5770	PDT	denotes	all
T3519	5790-5793	NN	denotes	QTL
T3520	5771-5774	DT	denotes	the
T3521	5775-5789	JJ	denotes	aforementioned
T3522	5793-5794	.	denotes	.
T3523	5794-6022	sentence	denotes	Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.
T3524	5795-5801	JJ	denotes	Single
T3525	5802-5809	NNS	denotes	strains
T3526	5835-5842	VBN	denotes	created
T3527	5810-5812	IN	denotes	on
T3528	5813-5815	DT	denotes	an
T3529	5819-5829	NN	denotes	background
T3530	5816-5818	NN	denotes	HG
T3531	5830-5834	VBD	denotes	were
T3532	5843-5846	IN	denotes	for
T3533	5847-5851	DT	denotes	each
T3534	5864-5870	NN	denotes	region
T3535	5852-5863	JJ	denotes	chromosomal
T3536	5871-5878	IN	denotes	outside
T3537	5879-5881	IN	denotes	of
T3538	5882-5886	NN	denotes	MMU2
T3539	5886-5888	,	denotes	,
T3540	5888-5893	IN	denotes	while
T3541	6003-6012	VBN	denotes	developed
T3542	5894-5895	DT	denotes	a
T3543	5910-5915	NN	denotes	panel
T3544	5896-5909	JJ	denotes	comprehensive
T3545	5916-5918	IN	denotes	of
T3546	5919-5930	VBG	denotes	overlapping
T3547	5931-5938	NNS	denotes	strains
T3548	5939-5943	IN	denotes	with
T3549	5944-5953	JJ	denotes	identical
T3550	5960-5967	NNS	denotes	regions
T3551	5954-5959	NN	denotes	donor
T3552	5968-5970	IN	denotes	on
T3553	5971-5975	CC	denotes	both
T3554	5976-5978	NN	denotes	B6
T3555	5986-5997	NNS	denotes	backgrounds
T3556	5979-5982	CC	denotes	and
T3557	5983-5985	NN	denotes	HG
T3558	5998-6002	VBD	denotes	were
T3559	6013-6016	IN	denotes	for
T3560	6017-6021	NN	denotes	MMU2
T3561	6021-6022	.	denotes	.
T3562	6022-6125	sentence	denotes	The MMU2 panel was developed to confirm the presence of multiple QTL and test for QTL-hg interactions.
T3563	6023-6026	DT	denotes	The
T3564	6032-6037	NN	denotes	panel
T3565	6027-6031	NN	denotes	MMU2
T3566	6042-6051	VBN	denotes	developed
T3567	6038-6041	VBD	denotes	was
T3568	6052-6054	TO	denotes	to
T3569	6055-6062	VB	denotes	confirm
T3570	6063-6066	DT	denotes	the
T3571	6067-6075	NN	denotes	presence
T3572	6076-6078	IN	denotes	of
T3573	6079-6087	JJ	denotes	multiple
T3574	6088-6091	NN	denotes	QTL
T3575	6092-6095	CC	denotes	and
T3576	6096-6100	VB	denotes	test
T3577	6101-6104	IN	denotes	for
T3578	6105-6108	NN	denotes	QTL
T3579	6109-6111	NN	denotes	hg
T3580	6108-6109	HYPH	denotes	-
T3581	6112-6124	NNS	denotes	interactions
T3582	6124-6125	.	denotes	.
T3583	6125-6317	sentence	denotes	Additionally, based on the knowledge of potential QTL-hg interactions, genes involved in Gh signaling, whose genomic location overlapped hg modifier QTL on MMU2, 9, 11 and 17, were sequenced.
T3584	6126-6138	RB	denotes	Additionally
T3585	6307-6316	VBN	denotes	sequenced
T3586	6138-6140	,	denotes	,
T3587	6140-6145	VBN	denotes	based
T3588	6146-6148	IN	denotes	on
T3589	6149-6152	DT	denotes	the
T3590	6153-6162	NN	denotes	knowledge
T3591	6163-6165	IN	denotes	of
T3592	6166-6175	JJ	denotes	potential
T3593	6183-6195	NNS	denotes	interactions
T3594	6176-6179	NN	denotes	QTL
T3595	6180-6182	NN	denotes	hg
T3596	6179-6180	HYPH	denotes	-
T3597	6195-6197	,	denotes	,
T3598	6197-6202	NNS	denotes	genes
T3599	6203-6211	VBN	denotes	involved
T3600	6212-6214	IN	denotes	in
T3601	6215-6217	NN	denotes	Gh
T3602	6218-6227	NN	denotes	signaling
T3603	6227-6229	,	denotes	,
T3604	6229-6234	WP$	denotes	whose
T3605	6243-6251	NN	denotes	location
T3606	6235-6242	JJ	denotes	genomic
T3607	6252-6262	VBD	denotes	overlapped
T3608	6263-6265	NN	denotes	hg
T3609	6275-6278	NN	denotes	QTL
T3610	6266-6274	NN	denotes	modifier
T3611	6279-6281	IN	denotes	on
T3612	6282-6285	NN	denotes	MMU
T3613	6285-6286	CD	denotes	2
T3614	6286-6288	,	denotes	,
T3615	6288-6289	CD	denotes	9
T3616	6289-6291	,	denotes	,
T3617	6291-6293	CD	denotes	11
T3618	6294-6297	CC	denotes	and
T3619	6298-6300	CD	denotes	17
T3620	6300-6302	,	denotes	,
T3621	6302-6306	VBD	denotes	were
T3622	6316-6317	.	denotes	.
T4080	6328-6333	NN	denotes	Speed
T4081	6334-6342	JJ	denotes	congenic
T4082	6343-6349	NN	denotes	strain
T4083	6350-6361	NN	denotes	development
T4084	6361-6511	sentence	denotes	Two speed congenic panels were created, the first comprehensively dissected MMU2 while the second isolated QTL on MMU1, 5, 8, 9, 11 and 17 (Table 1).
T4085	6362-6365	CD	denotes	Two
T4086	6381-6387	NNS	denotes	panels
T4087	6366-6371	NN	denotes	speed
T4088	6372-6380	JJ	denotes	congenic
T4089	6393-6400	VBN	denotes	created
T4090	6388-6392	VBD	denotes	were
T4091	6400-6402	,	denotes	,
T4092	6402-6405	DT	denotes	the
T4093	6406-6411	JJ	denotes	first
T4094	6428-6437	VBN	denotes	dissected
T4095	6412-6427	RB	denotes	comprehensively
T4096	6438-6442	NN	denotes	MMU2
T4097	6443-6448	IN	denotes	while
T4098	6460-6468	VBN	denotes	isolated
T4099	6449-6452	DT	denotes	the
T4100	6453-6459	JJ	denotes	second
T4101	6469-6472	NN	denotes	QTL
T4102	6473-6475	IN	denotes	on
T4103	6476-6479	NN	denotes	MMU
T4104	6479-6480	CD	denotes	1
T4105	6480-6482	,	denotes	,
T4106	6482-6483	CD	denotes	5
T4107	6483-6485	,	denotes	,
T4108	6485-6486	CD	denotes	8
T4109	6486-6488	,	denotes	,
T4110	6488-6489	CD	denotes	9
T4111	6489-6491	,	denotes	,
T4112	6491-6493	CD	denotes	11
T4113	6494-6497	CC	denotes	and
T4114	6498-6500	CD	denotes	17
T4115	6501-6502	-LRB-	denotes	(
T4116	6502-6507	NN	denotes	Table
T4117	6508-6509	CD	denotes	1
T4118	6509-6510	-RRB-	denotes	)
T4119	6510-6511	.	denotes	.
T4120	6511-6671	sentence	denotes	The MMU2 panel consisted of eight congenic strains developed by introgressing four overlapping donor regions onto both B6 and HG genetic backgrounds (Table 1).
T4121	6512-6515	DT	denotes	The
T4122	6521-6526	NN	denotes	panel
T4123	6516-6520	NN	denotes	MMU2
T4124	6527-6536	VBD	denotes	consisted
T4125	6537-6539	IN	denotes	of
T4126	6540-6545	CD	denotes	eight
T4127	6555-6562	NNS	denotes	strains
T4128	6546-6554	JJ	denotes	congenic
T4129	6563-6572	VBN	denotes	developed
T4130	6573-6575	IN	denotes	by
T4131	6576-6589	VBG	denotes	introgressing
T4132	6590-6594	CD	denotes	four
T4133	6613-6620	NNS	denotes	regions
T4134	6595-6606	VBG	denotes	overlapping
T4135	6607-6612	NN	denotes	donor
T4136	6621-6625	IN	denotes	onto
T4137	6626-6630	CC	denotes	both
T4138	6631-6633	NN	denotes	B6
T4139	6649-6660	NNS	denotes	backgrounds
T4140	6634-6637	CC	denotes	and
T4141	6638-6640	NN	denotes	HG
T4142	6641-6648	JJ	denotes	genetic
T4143	6661-6662	-LRB-	denotes	(
T4144	6662-6667	NN	denotes	Table
T4145	6668-6669	CD	denotes	1
T4146	6669-6670	-RRB-	denotes	)
T4147	6670-6671	.	denotes	.
T4148	6671-6790	sentence	denotes	Single donor regions bred onto an HG background were created to isolate the remaining QTL on MMU1, 5, 8, 9, 11 and 17.
T4149	6672-6678	JJ	denotes	Single
T4150	6685-6692	NNS	denotes	regions
T4151	6679-6684	NN	denotes	donor
T4152	6725-6732	VBN	denotes	created
T4153	6693-6697	VBN	denotes	bred
T4154	6698-6702	IN	denotes	onto
T4155	6703-6705	DT	denotes	an
T4156	6709-6719	NN	denotes	background
T4157	6706-6708	NN	denotes	HG
T4158	6720-6724	VBD	denotes	were
T4159	6733-6735	TO	denotes	to
T4160	6736-6743	VB	denotes	isolate
T4161	6744-6747	DT	denotes	the
T4162	6758-6761	NN	denotes	QTL
T4163	6748-6757	VBG	denotes	remaining
T4164	6762-6764	IN	denotes	on
T4165	6765-6768	NN	denotes	MMU
T4166	6768-6769	CD	denotes	1
T4167	6769-6771	,	denotes	,
T4168	6771-6772	CD	denotes	5
T4169	6772-6774	,	denotes	,
T4170	6774-6775	CD	denotes	8
T4171	6775-6777	,	denotes	,
T4172	6777-6778	CD	denotes	9
T4173	6778-6780	,	denotes	,
T4174	6780-6782	CD	denotes	11
T4175	6783-6786	CC	denotes	and
T4176	6787-6789	CD	denotes	17
T4177	6789-6790	.	denotes	.
T4178	6790-6986	sentence	denotes	Implementation of a speed congenic approach using marker-assisted breeding with 79 genome-wide microsatellite markers accelerated production of all strains [5,6] (Additional File 1 and Figure 1).
T4179	6791-6805	NN	denotes	Implementation
T4180	6909-6920	VBD	denotes	accelerated
T4181	6806-6808	IN	denotes	of
T4182	6809-6810	DT	denotes	a
T4183	6826-6834	NN	denotes	approach
T4184	6811-6816	NN	denotes	speed
T4185	6817-6825	JJ	denotes	congenic
T4186	6835-6840	VBG	denotes	using
T4187	6841-6847	NN	denotes	marker
T4188	6848-6856	VBN	denotes	assisted
T4189	6847-6848	HYPH	denotes	-
T4190	6857-6865	NN	denotes	breeding
T4191	6866-6870	IN	denotes	with
T4192	6871-6873	CD	denotes	79
T4193	6901-6908	NNS	denotes	markers
T4194	6874-6880	NN	denotes	genome
T4195	6881-6885	JJ	denotes	wide
T4196	6880-6881	HYPH	denotes	-
T4197	6886-6900	NN	denotes	microsatellite
T4198	6921-6931	NN	denotes	production
T4199	6932-6934	IN	denotes	of
T4200	6935-6938	DT	denotes	all
T4201	6939-6946	NNS	denotes	strains
T4202	6947-6948	-LRB-	denotes	[
T4203	6950-6951	CD	denotes	6
T4204	6948-6949	CD	denotes	5
T4205	6949-6950	,	denotes	,
T4206	6951-6952	-RRB-	denotes	]
T4207	6953-6954	-LRB-	denotes	(
T4208	6965-6969	NN	denotes	File
T4209	6954-6964	JJ	denotes	Additional
T4210	6970-6971	CD	denotes	1
T4211	6972-6975	CC	denotes	and
T4212	6976-6982	NN	denotes	Figure
T4213	6983-6984	CD	denotes	1
T4214	6984-6985	-RRB-	denotes	)
T4215	6985-6986	.	denotes	.
T4216	6986-7073	sentence	denotes	Strain abbreviations and genomic region isolated by each strain are listed in Table 1.
T4217	6987-6993	NN	denotes	Strain
T4218	6994-7007	NNS	denotes	abbreviations
T4219	7055-7061	VBN	denotes	listed
T4220	7008-7011	CC	denotes	and
T4221	7012-7019	JJ	denotes	genomic
T4222	7020-7026	NN	denotes	region
T4223	7027-7035	VBN	denotes	isolated
T4224	7036-7038	IN	denotes	by
T4225	7039-7043	DT	denotes	each
T4226	7044-7050	NN	denotes	strain
T4227	7051-7054	VBP	denotes	are
T4228	7062-7064	IN	denotes	in
T4229	7065-7070	NN	denotes	Table
T4230	7071-7072	CD	denotes	1
T4231	7072-7073	.	denotes	.
T4232	7073-7317	sentence	denotes	In addition to both congenic panels, two control strains homozygous B6 (B6.CASTC; B6C) or HG (HG.CASTC; HGC) for all genome-wide markers genotyped were developed from the same cross (see Methods) and served as the basis for strain comparisons.
T4233	7074-7076	IN	denotes	In
T4234	7226-7235	VBN	denotes	developed
T4235	7077-7085	NN	denotes	addition
T4236	7086-7088	IN	denotes	to
T4237	7089-7093	CC	denotes	both
T4238	7103-7109	NNS	denotes	panels
T4239	7094-7102	JJ	denotes	congenic
T4240	7109-7111	,	denotes	,
T4241	7111-7114	CD	denotes	two
T4242	7123-7130	NNS	denotes	strains
T4243	7115-7122	NN	denotes	control
T4244	7131-7141	JJ	denotes	homozygous
T4245	7142-7144	NN	denotes	B6
T4246	7145-7146	-LRB-	denotes	(
T4247	7146-7154	NN	denotes	B6.CASTC
T4248	7156-7159	NN	denotes	B6C
T4249	7154-7155	:	denotes	;
T4250	7159-7160	-RRB-	denotes	)
T4251	7161-7163	CC	denotes	or
T4252	7164-7166	NN	denotes	HG
T4253	7167-7168	-LRB-	denotes	(
T4254	7168-7176	NN	denotes	HG.CASTC
T4255	7178-7181	NN	denotes	HGC
T4256	7176-7177	:	denotes	;
T4257	7181-7182	-RRB-	denotes	)
T4258	7183-7186	IN	denotes	for
T4259	7187-7190	DT	denotes	all
T4260	7203-7210	NNS	denotes	markers
T4261	7191-7197	NN	denotes	genome
T4262	7198-7202	JJ	denotes	wide
T4263	7197-7198	HYPH	denotes	-
T4264	7211-7220	VBN	denotes	genotyped
T4265	7221-7225	VBD	denotes	were
T4266	7236-7240	IN	denotes	from
T4267	7241-7244	DT	denotes	the
T4268	7250-7255	NN	denotes	cross
T4269	7245-7249	JJ	denotes	same
T4270	7256-7257	-LRB-	denotes	(
T4271	7257-7260	VB	denotes	see
T4272	7261-7268	NNS	denotes	Methods
T4273	7268-7269	-RRB-	denotes	)
T4274	7270-7273	CC	denotes	and
T4275	7274-7280	VBD	denotes	served
T4276	7281-7283	IN	denotes	as
T4277	7284-7287	DT	denotes	the
T4278	7288-7293	NN	denotes	basis
T4279	7294-7297	IN	denotes	for
T4280	7298-7304	NN	denotes	strain
T4281	7305-7316	NNS	denotes	comparisons
T4282	7316-7317	.	denotes	.
T4283	7317-7419	sentence	denotes	After stabilizing each congenic, 12 of 14 were phenotypically characterized for growth and adiposity.
T4284	7318-7323	IN	denotes	After
T4285	7380-7393	VBN	denotes	characterized
T4286	7324-7335	VBG	denotes	stabilizing
T4287	7336-7340	DT	denotes	each
T4288	7341-7349	JJ	denotes	congenic
T4289	7349-7351	,	denotes	,
T4290	7351-7353	CD	denotes	12
T4291	7357-7359	CD	denotes	14
T4292	7354-7356	IN	denotes	of
T4293	7360-7364	VBD	denotes	were
T4294	7365-7379	RB	denotes	phenotypically
T4295	7394-7397	IN	denotes	for
T4296	7398-7404	NN	denotes	growth
T4297	7405-7408	CC	denotes	and
T4298	7409-7418	NN	denotes	adiposity
T4299	7418-7419	.	denotes	.
T4300	7419-7497	sentence	denotes	The HG2D and HG5 strains were not characterized due to reproductive problems.
T4301	7420-7423	DT	denotes	The
T4302	7437-7444	NNS	denotes	strains
T4303	7424-7428	NN	denotes	HG2D
T4304	7429-7432	CC	denotes	and
T4305	7433-7436	NN	denotes	HG5
T4306	7454-7467	VBN	denotes	characterized
T4307	7445-7449	VBD	denotes	were
T4308	7450-7453	RB	denotes	not
T4309	7468-7471	IN	denotes	due
T4310	7472-7474	IN	denotes	to
T4311	7475-7487	JJ	denotes	reproductive
T4312	7488-7496	NNS	denotes	problems
T4313	7496-7497	.	denotes	.
T4314	7497-7630	sentence	denotes	The recombinant end points for all strains were refined using microsatellite markers flanking each donor region (Additional File 2).
T4315	7498-7501	DT	denotes	The
T4316	7518-7524	NNS	denotes	points
T4317	7502-7513	JJ	denotes	recombinant
T4318	7514-7517	NN	denotes	end
T4319	7546-7553	VBN	denotes	refined
T4320	7525-7528	IN	denotes	for
T4321	7529-7532	DT	denotes	all
T4322	7533-7540	NNS	denotes	strains
T4323	7541-7545	VBD	denotes	were
T4324	7554-7559	VBG	denotes	using
T4325	7560-7574	NN	denotes	microsatellite
T4326	7575-7582	NNS	denotes	markers
T4327	7583-7591	VBG	denotes	flanking
T4328	7592-7596	DT	denotes	each
T4329	7603-7609	NN	denotes	region
T4330	7597-7602	NN	denotes	donor
T4331	7610-7611	-LRB-	denotes	(
T4332	7622-7626	NN	denotes	File
T4333	7611-7621	JJ	denotes	Additional
T4334	7627-7628	CD	denotes	2
T4335	7628-7629	-RRB-	denotes	)
T4336	7629-7630	.	denotes	.
T6950	7632-7636	NN	denotes	MMU2
T6951	7652-7658	NN	denotes	strain
T6952	7637-7642	NN	denotes	speed
T6953	7643-7651	JJ	denotes	congenic
T6954	7659-7675	NN	denotes	characterization
T6955	7675-7825	sentence	denotes	Due to the overlapping nature of the MMU2 congenics, five distinct chromosomal regions (Regions I–V) were queried for the presence of QTL (Figure 2).
T6956	7676-7679	IN	denotes	Due
T6957	7782-7789	VBN	denotes	queried
T6958	7680-7682	IN	denotes	to
T6959	7683-7686	DT	denotes	the
T6960	7699-7705	NN	denotes	nature
T6961	7687-7698	VBG	denotes	overlapping
T6962	7706-7708	IN	denotes	of
T6963	7709-7712	DT	denotes	the
T6964	7718-7727	NNS	denotes	congenics
T6965	7713-7717	NN	denotes	MMU2
T6966	7727-7729	,	denotes	,
T6967	7729-7733	CD	denotes	five
T6968	7755-7762	NNS	denotes	regions
T6969	7734-7742	JJ	denotes	distinct
T6970	7743-7754	JJ	denotes	chromosomal
T6971	7763-7764	-LRB-	denotes	(
T6972	7764-7771	NNS	denotes	Regions
T6973	7772-7773	CD	denotes	I
T6974	7773-7774	SYM	denotes	–
T6975	7774-7775	CD	denotes	V
T6976	7775-7776	-RRB-	denotes	)
T6977	7777-7781	VBD	denotes	were
T6978	7790-7793	IN	denotes	for
T6979	7794-7797	DT	denotes	the
T6980	7798-7806	NN	denotes	presence
T6981	7807-7809	IN	denotes	of
T6982	7810-7813	NN	denotes	QTL
T6983	7814-7815	-LRB-	denotes	(
T6984	7815-7821	NN	denotes	Figure
T6985	7822-7823	CD	denotes	2
T6986	7823-7824	-RRB-	denotes	)
T6987	7824-7825	.	denotes	.
T6988	7825-7948	sentence	denotes	As a separate analysis we also tested for interactions between each donor region and the two distinct genetic backgrounds.
T6989	7826-7828	IN	denotes	As
T6990	7857-7863	VBN	denotes	tested
T6991	7829-7830	DT	denotes	a
T6992	7840-7848	NN	denotes	analysis
T6993	7831-7839	JJ	denotes	separate
T6994	7849-7851	PRP	denotes	we
T6995	7852-7856	RB	denotes	also
T6996	7864-7867	IN	denotes	for
T6997	7868-7880	NNS	denotes	interactions
T6998	7881-7888	IN	denotes	between
T6999	7889-7893	DT	denotes	each
T7000	7900-7906	NN	denotes	region
T7001	7894-7899	NN	denotes	donor
T7002	7907-7910	CC	denotes	and
T7003	7911-7914	DT	denotes	the
T7004	7936-7947	NNS	denotes	backgrounds
T7005	7915-7918	CD	denotes	two
T7006	7919-7927	JJ	denotes	distinct
T7007	7928-7935	JJ	denotes	genetic
T7008	7947-7948	.	denotes	.
T7009	7948-8098	sentence	denotes	The following sections describe the phenotypes for each B6.CAST and HG.CAST speed congenic strain as well as the results of the interaction analysis.
T7010	7949-7952	DT	denotes	The
T7011	7963-7971	NNS	denotes	sections
T7012	7953-7962	JJ	denotes	following
T7013	7972-7980	VBP	denotes	describe
T7014	7981-7984	DT	denotes	the
T7015	7985-7995	NNS	denotes	phenotypes
T7016	7996-7999	IN	denotes	for
T7017	8000-8004	DT	denotes	each
T7018	8040-8046	NN	denotes	strain
T7019	8005-8012	NN	denotes	B6.CAST
T7020	8013-8016	CC	denotes	and
T7021	8017-8024	NN	denotes	HG.CAST
T7022	8025-8030	NN	denotes	speed
T7023	8031-8039	JJ	denotes	congenic
T7024	8047-8049	RB	denotes	as
T7025	8055-8057	IN	denotes	as
T7026	8050-8054	RB	denotes	well
T7027	8058-8061	DT	denotes	the
T7028	8062-8069	NNS	denotes	results
T7029	8070-8072	IN	denotes	of
T7030	8073-8076	DT	denotes	the
T7031	8089-8097	NN	denotes	analysis
T7032	8077-8088	NN	denotes	interaction
T7033	8097-8098	.	denotes	.
T7034	8098-8135	sentence	denotes	B6.CAST MMU2 speed congenic strains
T7035	8100-8107	NN	denotes	B6.CAST
T7036	8108-8112	NN	denotes	MMU2
T7037	8128-8135	NNS	denotes	strains
T7038	8113-8118	NN	denotes	speed
T7039	8119-8127	JJ	denotes	congenic
T7040	8135-8256	sentence	denotes	The B62D strain exhibited the largest (P < 0.0001) decreases in body weight of any B6.CAST congenic (Additional File 3).
T7041	8136-8139	DT	denotes	The
T7042	8145-8151	NN	denotes	strain
T7043	8140-8144	NN	denotes	B62D
T7044	8152-8161	VBD	denotes	exhibited
T7045	8162-8165	DT	denotes	the
T7046	8187-8196	NNS	denotes	decreases
T7047	8166-8173	JJS	denotes	largest
T7048	8174-8175	-LRB-	denotes	(
T7049	8179-8185	CD	denotes	0.0001
T7050	8175-8176	NN	denotes	P
T7051	8177-8178	SYM	denotes	<
T7052	8185-8186	-RRB-	denotes	)
T7053	8197-8199	IN	denotes	in
T7054	8200-8204	NN	denotes	body
T7055	8205-8211	NN	denotes	weight
T7056	8212-8214	IN	denotes	of
T7057	8215-8218	DT	denotes	any
T7058	8219-8226	NN	denotes	B6.CAST
T7059	8227-8235	JJ	denotes	congenic
T7060	8236-8237	-LRB-	denotes	(
T7061	8248-8252	NN	denotes	File
T7062	8237-8247	JJ	denotes	Additional
T7063	8253-8254	CD	denotes	3
T7064	8254-8255	-RRB-	denotes	)
T7065	8255-8256	.	denotes	.
T7066	8256-8387	sentence	denotes	Both sexes had reductions in weight at 2 (2WK), 3 (3WK), 6 (6WK) and 9 (9WK) weeks of age compared to control B6C mice (Figure 3).
T7067	8257-8261	DT	denotes	Both
T7068	8262-8267	NNS	denotes	sexes
T7069	8268-8271	VBD	denotes	had
T7070	8272-8282	NNS	denotes	reductions
T7071	8283-8285	IN	denotes	in
T7072	8286-8292	NN	denotes	weight
T7073	8293-8295	IN	denotes	at
T7074	8296-8297	CD	denotes	2
T7075	8334-8339	NNS	denotes	weeks
T7076	8298-8299	-LRB-	denotes	(
T7077	8299-8302	NN	denotes	2WK
T7078	8302-8303	-RRB-	denotes	)
T7079	8303-8305	,	denotes	,
T7080	8305-8306	CD	denotes	3
T7081	8307-8308	-LRB-	denotes	(
T7082	8308-8311	NN	denotes	3WK
T7083	8311-8312	-RRB-	denotes	)
T7084	8312-8314	,	denotes	,
T7085	8314-8315	CD	denotes	6
T7086	8316-8317	-LRB-	denotes	(
T7087	8317-8320	NN	denotes	6WK
T7088	8320-8321	-RRB-	denotes	)
T7089	8322-8325	CC	denotes	and
T7090	8326-8327	CD	denotes	9
T7091	8328-8329	-LRB-	denotes	(
T7092	8329-8332	NN	denotes	9WK
T7093	8332-8333	-RRB-	denotes	)
T7094	8340-8342	IN	denotes	of
T7095	8343-8346	NN	denotes	age
T7096	8347-8355	VBN	denotes	compared
T7097	8356-8358	IN	denotes	to
T7098	8359-8366	NN	denotes	control
T7099	8371-8375	NNS	denotes	mice
T7100	8367-8370	NN	denotes	B6C
T7101	8376-8377	-LRB-	denotes	(
T7102	8377-8383	NN	denotes	Figure
T7103	8384-8385	CD	denotes	3
T7104	8385-8386	-RRB-	denotes	)
T7105	8386-8387	.	denotes	.
T7106	8387-8569	sentence	denotes	Despite large decreases in body weight, no differences in growth rates (G26, weight gain from 2 to 6 weeks and G29, weight gain from 2 to 9 weeks) were observed (Additional File 3).
T7107	8388-8395	IN	denotes	Despite
T7108	8540-8548	VBN	denotes	observed
T7109	8396-8401	JJ	denotes	large
T7110	8402-8411	NNS	denotes	decreases
T7111	8412-8414	IN	denotes	in
T7112	8415-8419	NN	denotes	body
T7113	8420-8426	NN	denotes	weight
T7114	8426-8428	,	denotes	,
T7115	8428-8430	DT	denotes	no
T7116	8431-8442	NNS	denotes	differences
T7117	8443-8445	IN	denotes	in
T7118	8446-8452	NN	denotes	growth
T7119	8453-8458	NNS	denotes	rates
T7120	8459-8460	-LRB-	denotes	(
T7121	8472-8476	NN	denotes	gain
T7122	8460-8463	NN	denotes	G26
T7123	8463-8465	,	denotes	,
T7124	8465-8471	NN	denotes	weight
T7125	8477-8481	IN	denotes	from
T7126	8482-8483	CD	denotes	2
T7127	8487-8488	CD	denotes	6
T7128	8484-8486	IN	denotes	to
T7129	8489-8494	NNS	denotes	weeks
T7130	8495-8498	CC	denotes	and
T7131	8499-8502	NN	denotes	G29
T7132	8511-8515	NN	denotes	gain
T7133	8502-8504	,	denotes	,
T7134	8504-8510	NN	denotes	weight
T7135	8516-8520	IN	denotes	from
T7136	8521-8522	CD	denotes	2
T7137	8526-8527	CD	denotes	9
T7138	8523-8525	IN	denotes	to
T7139	8528-8533	NNS	denotes	weeks
T7140	8533-8534	-RRB-	denotes	)
T7141	8535-8539	VBD	denotes	were
T7142	8549-8550	-LRB-	denotes	(
T7143	8561-8565	NN	denotes	File
T7144	8550-8560	JJ	denotes	Additional
T7145	8566-8567	CD	denotes	3
T7146	8567-8568	-RRB-	denotes	)
T7147	8568-8569	.	denotes	.
T7148	8569-8741	sentence	denotes	Therefore, the B62D unique region (Region V) harbors either an early-growth QTL or maternal genotype effect which produces a distinct decrease in body weight prior to 2WK.
T7149	8570-8579	RB	denotes	Therefore
T7150	8615-8622	VBZ	denotes	harbors
T7151	8579-8581	,	denotes	,
T7152	8581-8584	DT	denotes	the
T7153	8597-8603	NN	denotes	region
T7154	8585-8589	NN	denotes	B62D
T7155	8590-8596	JJ	denotes	unique
T7156	8604-8605	-LRB-	denotes	(
T7157	8605-8611	NN	denotes	Region
T7158	8612-8613	CD	denotes	V
T7159	8613-8614	-RRB-	denotes	)
T7160	8623-8629	CC	denotes	either
T7161	8646-8649	NN	denotes	QTL
T7162	8630-8632	DT	denotes	an
T7163	8633-8638	JJ	denotes	early
T7164	8639-8645	NN	denotes	growth
T7165	8638-8639	HYPH	denotes	-
T7166	8650-8652	CC	denotes	or
T7167	8653-8661	JJ	denotes	maternal
T7168	8671-8677	NN	denotes	effect
T7169	8662-8670	NN	denotes	genotype
T7170	8678-8683	WDT	denotes	which
T7171	8684-8692	VBZ	denotes	produces
T7172	8693-8694	DT	denotes	a
T7173	8704-8712	NN	denotes	decrease
T7174	8695-8703	JJ	denotes	distinct
T7175	8713-8715	IN	denotes	in
T7176	8716-8720	NN	denotes	body
T7177	8721-8727	NN	denotes	weight
T7178	8728-8733	JJ	denotes	prior
T7179	8734-8736	IN	denotes	to
T7180	8737-8740	NN	denotes	2WK
T7181	8740-8741	.	denotes	.
T7182	8741-8830	sentence	denotes	These effects are evident in the growth curves for both sexes of each strain (Figure 3).
T7183	8742-8747	DT	denotes	These
T7184	8748-8755	NNS	denotes	effects
T7185	8756-8759	VBP	denotes	are
T7186	8760-8767	JJ	denotes	evident
T7187	8768-8770	IN	denotes	in
T7188	8771-8774	DT	denotes	the
T7189	8782-8788	NNS	denotes	curves
T7190	8775-8781	NN	denotes	growth
T7191	8789-8792	IN	denotes	for
T7192	8793-8797	DT	denotes	both
T7193	8798-8803	NNS	denotes	sexes
T7194	8804-8806	IN	denotes	of
T7195	8807-8811	DT	denotes	each
T7196	8812-8818	NN	denotes	strain
T7197	8819-8820	-LRB-	denotes	(
T7198	8820-8826	NN	denotes	Figure
T7199	8827-8828	CD	denotes	3
T7200	8828-8829	-RRB-	denotes	)
T7201	8829-8830	.	denotes	.
T7202	8830-8957	sentence	denotes	Additionally, B62D mice displayed significantly shorter tail lengths despite no difference in naso-anal length (NA) (Table 2).
T7203	8831-8843	RB	denotes	Additionally
T7204	8855-8864	VBD	denotes	displayed
T7205	8843-8845	,	denotes	,
T7206	8845-8849	NN	denotes	B62D
T7207	8850-8854	NNS	denotes	mice
T7208	8865-8878	RB	denotes	significantly
T7209	8879-8886	JJR	denotes	shorter
T7210	8892-8899	NNS	denotes	lengths
T7211	8887-8891	NN	denotes	tail
T7212	8900-8907	IN	denotes	despite
T7213	8908-8910	DT	denotes	no
T7214	8911-8921	NN	denotes	difference
T7215	8922-8924	IN	denotes	in
T7216	8925-8934	JJ	denotes	naso-anal
T7217	8935-8941	NN	denotes	length
T7218	8942-8943	-LRB-	denotes	(
T7219	8943-8945	NN	denotes	NA
T7220	8945-8946	-RRB-	denotes	)
T7221	8947-8948	-LRB-	denotes	(
T7222	8948-8953	NN	denotes	Table
T7223	8954-8955	CD	denotes	2
T7224	8955-8956	-RRB-	denotes	)
T7225	8956-8957	.	denotes	.
T7226	8957-9207	sentence	denotes	In contrast, B62M mice displayed small decreases in body weights and growth (male 9WK was significant, female 6WK and 9WK were suggestive at P < 0.05) and significant decreases in NA (male P = 0.0152) and tail length (Additional File 3 and Table 2).
T7227	8958-8960	IN	denotes	In
T7228	8981-8990	VBD	denotes	displayed
T7229	8961-8969	NN	denotes	contrast
T7230	8969-8971	,	denotes	,
T7231	8971-8975	NN	denotes	B62M
T7232	8976-8980	NNS	denotes	mice
T7233	8991-8996	JJ	denotes	small
T7234	8997-9006	NNS	denotes	decreases
T7235	9007-9009	IN	denotes	in
T7236	9010-9014	NN	denotes	body
T7237	9015-9022	NNS	denotes	weights
T7238	9023-9026	CC	denotes	and
T7239	9027-9033	NN	denotes	growth
T7240	9034-9035	-LRB-	denotes	(
T7241	9080-9084	VBD	denotes	were
T7242	9035-9039	JJ	denotes	male
T7243	9040-9043	NN	denotes	9WK
T7244	9044-9047	VBD	denotes	was
T7245	9048-9059	JJ	denotes	significant
T7246	9059-9061	,	denotes	,
T7247	9061-9067	JJ	denotes	female
T7248	9068-9071	NN	denotes	6WK
T7249	9072-9075	CC	denotes	and
T7250	9076-9079	NN	denotes	9WK
T7251	9085-9095	JJ	denotes	suggestive
T7252	9096-9098	IN	denotes	at
T7253	9099-9100	NN	denotes	P
T7254	9103-9107	CD	denotes	0.05
T7255	9101-9102	SYM	denotes	<
T7256	9107-9108	-RRB-	denotes	)
T7257	9109-9112	CC	denotes	and
T7258	9113-9124	JJ	denotes	significant
T7259	9125-9134	NNS	denotes	decreases
T7260	9135-9137	IN	denotes	in
T7261	9138-9140	NN	denotes	NA
T7262	9168-9174	NN	denotes	length
T7263	9141-9142	-LRB-	denotes	(
T7264	9151-9157	CD	denotes	0.0152
T7265	9142-9146	JJ	denotes	male
T7266	9147-9148	NN	denotes	P
T7267	9149-9150	SYM	denotes	=
T7268	9157-9158	-RRB-	denotes	)
T7269	9159-9162	CC	denotes	and
T7270	9163-9167	NN	denotes	tail
T7271	9175-9176	-LRB-	denotes	(
T7272	9187-9191	NN	denotes	File
T7273	9176-9186	JJ	denotes	Additional
T7274	9192-9193	CD	denotes	3
T7275	9194-9197	CC	denotes	and
T7276	9198-9203	NN	denotes	Table
T7277	9204-9205	CD	denotes	2
T7278	9205-9206	-RRB-	denotes	)
T7279	9206-9207	.	denotes	.
T7280	9207-9378	sentence	denotes	The decrease in NA in B62M mice is surprising since the 2M donor region is entirely nested within the 2D donor region and B62D mice showed no difference in NA (Figure 2).
T7281	9208-9211	DT	denotes	The
T7282	9212-9220	NN	denotes	decrease
T7283	9240-9242	VBZ	denotes	is
T7284	9221-9223	IN	denotes	in
T7285	9224-9226	NN	denotes	NA
T7286	9227-9229	IN	denotes	in
T7287	9230-9234	NN	denotes	B62M
T7288	9235-9239	NNS	denotes	mice
T7289	9243-9253	JJ	denotes	surprising
T7290	9254-9259	IN	denotes	since
T7291	9292-9298	VBN	denotes	nested
T7292	9260-9263	DT	denotes	the
T7293	9273-9279	NN	denotes	region
T7294	9264-9266	NN	denotes	2M
T7295	9267-9272	NN	denotes	donor
T7296	9280-9282	VBZ	denotes	is
T7297	9283-9291	RB	denotes	entirely
T7298	9299-9305	IN	denotes	within
T7299	9306-9309	DT	denotes	the
T7300	9319-9325	NN	denotes	region
T7301	9310-9312	NN	denotes	2D
T7302	9313-9318	NN	denotes	donor
T7303	9326-9329	CC	denotes	and
T7304	9330-9334	NN	denotes	B62D
T7305	9335-9339	NNS	denotes	mice
T7306	9340-9346	VBD	denotes	showed
T7307	9347-9349	DT	denotes	no
T7308	9350-9360	NN	denotes	difference
T7309	9361-9363	IN	denotes	in
T7310	9364-9366	NN	denotes	NA
T7311	9367-9368	-LRB-	denotes	(
T7312	9368-9374	NN	denotes	Figure
T7313	9375-9376	CD	denotes	2
T7314	9376-9377	-RRB-	denotes	)
T7315	9377-9378	.	denotes	.
T7316	9378-9451	sentence	denotes	These data indicate the presence of three QTL with the 2D unique region.
T7317	9379-9384	DT	denotes	These
T7318	9385-9389	NNS	denotes	data
T7319	9390-9398	VBP	denotes	indicate
T7320	9399-9402	DT	denotes	the
T7321	9403-9411	NN	denotes	presence
T7322	9412-9414	IN	denotes	of
T7323	9415-9420	CD	denotes	three
T7324	9421-9424	NN	denotes	QTL
T7325	9425-9429	IN	denotes	with
T7326	9430-9433	DT	denotes	the
T7327	9444-9450	NN	denotes	region
T7328	9434-9436	NN	denotes	2D
T7329	9437-9443	JJ	denotes	unique
T7330	9450-9451	.	denotes	.
T7331	9451-9572	sentence	denotes	Two of which are disjoined by the B62M and B62D strains and additively decrease body weight and tail length, but not NA.
T7332	9452-9455	CD	denotes	Two
T7333	9469-9478	VBN	denotes	disjoined
T7334	9456-9458	IN	denotes	of
T7335	9459-9464	WDT	denotes	which
T7336	9465-9468	VBP	denotes	are
T7337	9479-9481	IN	denotes	by
T7338	9482-9485	DT	denotes	the
T7339	9500-9507	NNS	denotes	strains
T7340	9486-9490	NN	denotes	B62M
T7341	9491-9494	CC	denotes	and
T7342	9495-9499	NN	denotes	B62D
T7343	9508-9511	CC	denotes	and
T7344	9512-9522	RB	denotes	additively
T7345	9523-9531	VBP	denotes	decrease
T7346	9532-9536	NN	denotes	body
T7347	9537-9543	NN	denotes	weight
T7348	9544-9547	CC	denotes	and
T7349	9548-9552	NN	denotes	tail
T7350	9553-9559	NN	denotes	length
T7351	9559-9561	,	denotes	,
T7352	9561-9564	CC	denotes	but
T7353	9565-9568	RB	denotes	not
T7354	9569-9571	NN	denotes	NA
T7355	9571-9572	.	denotes	.
T7356	9572-9715	sentence	denotes	The third QTL, located within the B62D unique region (Region V), increases NA canceling the effects of the B62M QTL (Region IV) decreasing NA.
T7357	9573-9576	DT	denotes	The
T7358	9583-9586	NN	denotes	QTL
T7359	9577-9582	JJ	denotes	third
T7360	9638-9647	VBZ	denotes	increases
T7361	9586-9588	,	denotes	,
T7362	9588-9595	VBN	denotes	located
T7363	9596-9602	IN	denotes	within
T7364	9603-9606	DT	denotes	the
T7365	9619-9625	NN	denotes	region
T7366	9607-9611	NN	denotes	B62D
T7367	9612-9618	JJ	denotes	unique
T7368	9626-9627	-LRB-	denotes	(
T7369	9627-9633	NN	denotes	Region
T7370	9634-9635	CD	denotes	V
T7371	9635-9636	-RRB-	denotes	)
T7372	9636-9638	,	denotes	,
T7373	9648-9650	NN	denotes	NA
T7374	9651-9660	VBG	denotes	canceling
T7375	9661-9664	DT	denotes	the
T7376	9665-9672	NNS	denotes	effects
T7377	9673-9675	IN	denotes	of
T7378	9676-9679	DT	denotes	the
T7379	9685-9688	NN	denotes	QTL
T7380	9680-9684	NN	denotes	B62M
T7381	9701-9711	VBG	denotes	decreasing
T7382	9689-9690	-LRB-	denotes	(
T7383	9690-9696	NN	denotes	Region
T7384	9697-9699	CD	denotes	IV
T7385	9699-9700	-RRB-	denotes	)
T7386	9712-9714	NN	denotes	NA
T7387	9714-9715	.	denotes	.
T7388	9715-9853	sentence	denotes	B62PM females had decreases in all growth-related traits except 2WK and 3WK, while no differences were seen in males (Additional File 3).
T7389	9716-9721	NN	denotes	B62PM
T7390	9722-9729	NNS	denotes	females
T7391	9730-9733	VBD	denotes	had
T7392	9734-9743	NNS	denotes	decreases
T7393	9744-9746	IN	denotes	in
T7394	9747-9750	DT	denotes	all
T7395	9766-9772	NNS	denotes	traits
T7396	9751-9757	NN	denotes	growth
T7397	9758-9765	VBN	denotes	related
T7398	9757-9758	HYPH	denotes	-
T7399	9773-9779	IN	denotes	except
T7400	9780-9783	NN	denotes	2WK
T7401	9784-9787	CC	denotes	and
T7402	9788-9791	NN	denotes	3WK
T7403	9791-9793	,	denotes	,
T7404	9793-9798	IN	denotes	while
T7405	9819-9823	VBN	denotes	seen
T7406	9799-9801	DT	denotes	no
T7407	9802-9813	NNS	denotes	differences
T7408	9814-9818	VBD	denotes	were
T7409	9824-9826	IN	denotes	in
T7410	9827-9832	NNS	denotes	males
T7411	9833-9834	-LRB-	denotes	(
T7412	9845-9849	NN	denotes	File
T7413	9834-9844	JJ	denotes	Additional
T7414	9850-9851	CD	denotes	3
T7415	9851-9852	-RRB-	denotes	)
T7416	9852-9853	.	denotes	.
T7417	9853-10043	sentence	denotes	Similarly, only B62P females and not males showed significant decreases in 9WK, G26 and G29 (Additional File 3), indicating these two strains share a female specific growth QTL (Region II).
T7418	9854-9863	RB	denotes	Similarly
T7419	9897-9903	VBD	denotes	showed
T7420	9863-9865	,	denotes	,
T7421	9865-9869	RB	denotes	only
T7422	9875-9882	NNS	denotes	females
T7423	9870-9874	NN	denotes	B62P
T7424	9883-9886	CC	denotes	and
T7425	9887-9890	RB	denotes	not
T7426	9891-9896	NNS	denotes	males
T7427	9904-9915	JJ	denotes	significant
T7428	9916-9925	NNS	denotes	decreases
T7429	9926-9928	IN	denotes	in
T7430	9929-9932	NN	denotes	9WK
T7431	9932-9934	,	denotes	,
T7432	9934-9937	NN	denotes	G26
T7433	9938-9941	CC	denotes	and
T7434	9942-9945	NN	denotes	G29
T7435	9946-9947	-LRB-	denotes	(
T7436	9958-9962	NN	denotes	File
T7437	9947-9957	JJ	denotes	Additional
T7438	9963-9964	CD	denotes	3
T7439	9964-9965	-RRB-	denotes	)
T7440	9965-9967	,	denotes	,
T7441	9967-9977	VBG	denotes	indicating
T7442	9978-9983	DT	denotes	these
T7443	9988-9995	NNS	denotes	strains
T7444	9984-9987	CD	denotes	two
T7445	9996-10001	VBP	denotes	share
T7446	10002-10003	DT	denotes	a
T7447	10027-10030	NN	denotes	QTL
T7448	10004-10010	JJ	denotes	female
T7449	10011-10019	JJ	denotes	specific
T7450	10020-10026	NN	denotes	growth
T7451	10031-10032	-LRB-	denotes	(
T7452	10032-10038	NN	denotes	Region
T7453	10039-10041	CD	denotes	II
T7454	10041-10042	-RRB-	denotes	)
T7455	10042-10043	.	denotes	.
T7456	10043-10180	sentence	denotes	In the original genome scan body fat percentage as determined by chemical compositional analysis was not linked to markers on MMU2 [24].
T7457	10044-10046	IN	denotes	In
T7458	10149-10155	VBN	denotes	linked
T7459	10047-10050	DT	denotes	the
T7460	10067-10071	NN	denotes	scan
T7461	10051-10059	JJ	denotes	original
T7462	10060-10066	NN	denotes	genome
T7463	10072-10076	NN	denotes	body
T7464	10077-10080	NN	denotes	fat
T7465	10081-10091	NN	denotes	percentage
T7466	10092-10094	IN	denotes	as
T7467	10095-10105	VBN	denotes	determined
T7468	10106-10108	IN	denotes	by
T7469	10109-10117	JJ	denotes	chemical
T7470	10132-10140	NN	denotes	analysis
T7471	10118-10131	JJ	denotes	compositional
T7472	10141-10144	VBD	denotes	was
T7473	10145-10148	RB	denotes	not
T7474	10156-10158	IN	denotes	to
T7475	10159-10166	NNS	denotes	markers
T7476	10167-10169	IN	denotes	on
T7477	10170-10174	NN	denotes	MMU2
T7478	10175-10176	-LRB-	denotes	[
T7479	10176-10178	CD	denotes	24
T7480	10178-10179	-RRB-	denotes	]
T7481	10179-10180	.	denotes	.
T7482	10180-10393	sentence	denotes	However, since numerous obesity QTL have been found on MMU2 [2], some of which were discovered in B6 by CAST crosses [9,25], we chose to measure dissected fat pad weights as a more sensitive measure of adiposity.
T7483	10181-10188	RB	denotes	However
T7484	10309-10314	VBD	denotes	chose
T7485	10188-10190	,	denotes	,
T7486	10190-10195	IN	denotes	since
T7487	10227-10232	VBN	denotes	found
T7488	10196-10204	JJ	denotes	numerous
T7489	10213-10216	NN	denotes	QTL
T7490	10205-10212	NN	denotes	obesity
T7491	10217-10221	VBP	denotes	have
T7492	10222-10226	VBN	denotes	been
T7493	10233-10235	IN	denotes	on
T7494	10236-10240	NN	denotes	MMU2
T7495	10241-10242	-LRB-	denotes	[
T7496	10242-10243	CD	denotes	2
T7497	10243-10244	-RRB-	denotes	]
T7498	10244-10246	,	denotes	,
T7499	10246-10250	DT	denotes	some
T7500	10265-10275	VBN	denotes	discovered
T7501	10251-10253	IN	denotes	of
T7502	10254-10259	WDT	denotes	which
T7503	10260-10264	VBD	denotes	were
T7504	10276-10278	IN	denotes	in
T7505	10279-10281	NN	denotes	B6
T7506	10282-10284	IN	denotes	by
T7507	10285-10289	NN	denotes	CAST
T7508	10290-10297	NNS	denotes	crosses
T7509	10298-10299	-LRB-	denotes	[
T7510	10301-10303	CD	denotes	25
T7511	10299-10300	CD	denotes	9
T7512	10300-10301	,	denotes	,
T7513	10303-10304	-RRB-	denotes	]
T7514	10304-10306	,	denotes	,
T7515	10306-10308	PRP	denotes	we
T7516	10315-10317	TO	denotes	to
T7517	10318-10325	VB	denotes	measure
T7518	10326-10335	VBN	denotes	dissected
T7519	10344-10351	NNS	denotes	weights
T7520	10336-10339	NN	denotes	fat
T7521	10340-10343	NN	denotes	pad
T7522	10352-10354	IN	denotes	as
T7523	10355-10356	DT	denotes	a
T7524	10372-10379	NN	denotes	measure
T7525	10357-10361	RBR	denotes	more
T7526	10362-10371	JJ	denotes	sensitive
T7527	10380-10382	IN	denotes	of
T7528	10383-10392	NN	denotes	adiposity
T7529	10392-10393	.	denotes	.
T7530	10393-10691	sentence	denotes	Table 2 lists the weights of gonadal (GFP), femoral (FFP), mesenteric (MFP) and retroperitoneal (RFP) fat pads, along with total fat pad weight (sum of the four fat pads), adiposity index (AI = TF/weight at sacrifice (WSAC)) and body mass index (BMI = WSAC/NA2 *100) for each MMU2 congenic strain.
T7531	10394-10399	NN	denotes	Table
T7532	10402-10407	VBZ	denotes	lists
T7533	10400-10401	CD	denotes	2
T7534	10408-10411	DT	denotes	the
T7535	10412-10419	NNS	denotes	weights
T7536	10420-10422	IN	denotes	of
T7537	10423-10430	JJ	denotes	gonadal
T7538	10500-10504	NNS	denotes	pads
T7539	10431-10432	-LRB-	denotes	(
T7540	10432-10435	NN	denotes	GFP
T7541	10435-10436	-RRB-	denotes	)
T7542	10436-10438	,	denotes	,
T7543	10438-10445	JJ	denotes	femoral
T7544	10446-10447	-LRB-	denotes	(
T7545	10447-10450	NN	denotes	FFP
T7546	10450-10451	-RRB-	denotes	)
T7547	10451-10453	,	denotes	,
T7548	10453-10463	JJ	denotes	mesenteric
T7549	10464-10465	-LRB-	denotes	(
T7550	10465-10468	NN	denotes	MFP
T7551	10468-10469	-RRB-	denotes	)
T7552	10470-10473	CC	denotes	and
T7553	10474-10489	JJ	denotes	retroperitoneal
T7554	10490-10491	-LRB-	denotes	(
T7555	10491-10494	NN	denotes	RFP
T7556	10494-10495	-RRB-	denotes	)
T7557	10496-10499	NN	denotes	fat
T7558	10504-10506	,	denotes	,
T7559	10506-10511	IN	denotes	along
T7560	10512-10516	IN	denotes	with
T7561	10517-10522	JJ	denotes	total
T7562	10531-10537	NN	denotes	weight
T7563	10523-10526	NN	denotes	fat
T7564	10527-10530	NN	denotes	pad
T7565	10538-10539	-LRB-	denotes	(
T7566	10539-10542	NN	denotes	sum
T7567	10543-10545	IN	denotes	of
T7568	10546-10549	DT	denotes	the
T7569	10559-10563	NNS	denotes	pads
T7570	10550-10554	CD	denotes	four
T7571	10555-10558	NN	denotes	fat
T7572	10563-10564	-RRB-	denotes	)
T7573	10564-10566	,	denotes	,
T7574	10566-10575	NN	denotes	adiposity
T7575	10576-10581	NN	denotes	index
T7576	10582-10583	-LRB-	denotes	(
T7577	10612-10616	NN	denotes	WSAC
T7578	10583-10585	NN	denotes	AI
T7579	10588-10590	NN	denotes	TF
T7580	10586-10587	SYM	denotes	=
T7581	10590-10591	SYM	denotes	/
T7582	10591-10597	NN	denotes	weight
T7583	10598-10600	IN	denotes	at
T7584	10601-10610	NN	denotes	sacrifice
T7585	10611-10612	-LRB-	denotes	(
T7586	10616-10617	-RRB-	denotes	)
T7587	10617-10618	-RRB-	denotes	)
T7588	10619-10622	CC	denotes	and
T7589	10623-10627	NN	denotes	body
T7590	10633-10638	NN	denotes	index
T7591	10628-10632	NN	denotes	mass
T7592	10639-10640	-LRB-	denotes	(
T7593	10646-10650	NN	denotes	WSAC
T7594	10640-10643	NN	denotes	BMI
T7595	10644-10645	SYM	denotes	=
T7596	10650-10651	SYM	denotes	/
T7597	10651-10654	NN	denotes	NA2
T7598	10655-10656	SYM	denotes	*
T7599	10656-10659	NN	denotes	100
T7600	10659-10660	-RRB-	denotes	)
T7601	10661-10664	IN	denotes	for
T7602	10665-10669	DT	denotes	each
T7603	10684-10690	NN	denotes	strain
T7604	10670-10674	NN	denotes	MMU2
T7605	10675-10683	JJ	denotes	congenic
T7606	10690-10691	.	denotes	.
T7607	10691-10804	sentence	denotes	Similar to large differences in body weight the B62D strain displayed highly significant decreases in adiposity.
T7608	10692-10699	JJ	denotes	Similar
T7609	10752-10761	VBD	denotes	displayed
T7610	10700-10702	IN	denotes	to
T7611	10703-10708	JJ	denotes	large
T7612	10709-10720	NNS	denotes	differences
T7613	10721-10723	IN	denotes	in
T7614	10724-10728	NN	denotes	body
T7615	10729-10735	NN	denotes	weight
T7616	10736-10739	DT	denotes	the
T7617	10745-10751	NN	denotes	strain
T7618	10740-10744	NN	denotes	B62D
T7619	10762-10768	RB	denotes	highly
T7620	10769-10780	JJ	denotes	significant
T7621	10781-10790	NNS	denotes	decreases
T7622	10791-10793	IN	denotes	in
T7623	10794-10803	NN	denotes	adiposity
T7624	10803-10804	.	denotes	.
T7625	10804-10891	sentence	denotes	B62D was the only strain where both sexes had significant decreases in TF, AI and BMI.
T7626	10805-10809	NN	denotes	B62D
T7627	10810-10813	VBD	denotes	was
T7628	10814-10817	DT	denotes	the
T7629	10823-10829	NN	denotes	strain
T7630	10818-10822	JJ	denotes	only
T7631	10830-10835	WRB	denotes	where
T7632	10847-10850	VBD	denotes	had
T7633	10836-10840	DT	denotes	both
T7634	10841-10846	NNS	denotes	sexes
T7635	10851-10862	JJ	denotes	significant
T7636	10863-10872	NNS	denotes	decreases
T7637	10873-10875	IN	denotes	in
T7638	10876-10878	NN	denotes	TF
T7639	10878-10880	,	denotes	,
T7640	10880-10882	NN	denotes	AI
T7641	10883-10886	CC	denotes	and
T7642	10887-10890	NN	denotes	BMI
T7643	10890-10891	.	denotes	.
T7644	10891-10956	sentence	denotes	Interestingly, no difference in adiposity was seen in B62M mice.
T7645	10892-10905	RB	denotes	Interestingly
T7646	10938-10942	VBN	denotes	seen
T7647	10905-10907	,	denotes	,
T7648	10907-10909	DT	denotes	no
T7649	10910-10920	NN	denotes	difference
T7650	10921-10923	IN	denotes	in
T7651	10924-10933	NN	denotes	adiposity
T7652	10934-10937	VBD	denotes	was
T7653	10943-10945	IN	denotes	in
T7654	10946-10950	NN	denotes	B62M
T7655	10951-10955	NNS	denotes	mice
T7656	10955-10956	.	denotes	.
T7657	10956-11059	sentence	denotes	This discordance indicates the leanness promoting QTL is located in the B62D unique region (Region V).
T7658	10957-10961	DT	denotes	This
T7659	10962-10973	NN	denotes	discordance
T7660	10974-10983	VBZ	denotes	indicates
T7661	10984-10987	DT	denotes	the
T7662	11007-11010	NN	denotes	QTL
T7663	10988-10996	NN	denotes	leanness
T7664	10997-11006	VBG	denotes	promoting
T7665	11014-11021	VBN	denotes	located
T7666	11011-11013	VBZ	denotes	is
T7667	11022-11024	IN	denotes	in
T7668	11025-11028	DT	denotes	the
T7669	11041-11047	NN	denotes	region
T7670	11029-11033	NN	denotes	B62D
T7671	11034-11040	JJ	denotes	unique
T7672	11048-11049	-LRB-	denotes	(
T7673	11049-11055	NN	denotes	Region
T7674	11056-11057	CD	denotes	V
T7675	11057-11058	-RRB-	denotes	)
T7676	11058-11059	.	denotes	.
T7677	11059-11165	sentence	denotes	Only minor differences in various fat pad weights were observed for the B62P and B62PM strains (Table 2).
T7678	11060-11064	RB	denotes	Only
T7679	11071-11082	NNS	denotes	differences
T7680	11065-11070	JJ	denotes	minor
T7681	11115-11123	VBN	denotes	observed
T7682	11083-11085	IN	denotes	in
T7683	11086-11093	JJ	denotes	various
T7684	11102-11109	NNS	denotes	weights
T7685	11094-11097	NN	denotes	fat
T7686	11098-11101	NN	denotes	pad
T7687	11110-11114	VBD	denotes	were
T7688	11124-11127	IN	denotes	for
T7689	11128-11131	DT	denotes	the
T7690	11147-11154	NNS	denotes	strains
T7691	11132-11136	NN	denotes	B62P
T7692	11137-11140	CC	denotes	and
T7693	11141-11146	NN	denotes	B62PM
T7694	11155-11156	-LRB-	denotes	(
T7695	11156-11161	NN	denotes	Table
T7696	11162-11163	CD	denotes	2
T7697	11163-11164	-RRB-	denotes	)
T7698	11164-11165	.	denotes	.
T7699	11165-11200	sentence	denotes	HG.CAST MMU2 speed congenic panel
T7700	11167-11174	NN	denotes	HG.CAST
T7701	11175-11179	NN	denotes	MMU2
T7702	11195-11200	NN	denotes	panel
T7703	11180-11185	NN	denotes	speed
T7704	11186-11194	JJ	denotes	congenic
T7705	11200-11334	sentence	denotes	HG2P and HG2PM mice of both sexes displayed significant decreases in post-weaning body weights and growth rates (Additional Table 3).
T7706	11201-11205	NN	denotes	HG2P
T7707	11216-11220	NNS	denotes	mice
T7708	11206-11209	CC	denotes	and
T7709	11210-11215	NN	denotes	HG2PM
T7710	11235-11244	VBD	denotes	displayed
T7711	11221-11223	IN	denotes	of
T7712	11224-11228	DT	denotes	both
T7713	11229-11234	NNS	denotes	sexes
T7714	11245-11256	JJ	denotes	significant
T7715	11257-11266	NNS	denotes	decreases
T7716	11267-11269	IN	denotes	in
T7717	11270-11282	JJ	denotes	post-weaning
T7718	11288-11295	NNS	denotes	weights
T7719	11283-11287	NN	denotes	body
T7720	11296-11299	CC	denotes	and
T7721	11300-11306	NN	denotes	growth
T7722	11307-11312	NNS	denotes	rates
T7723	11313-11314	-LRB-	denotes	(
T7724	11325-11330	NN	denotes	Table
T7725	11314-11324	JJ	denotes	Additional
T7726	11331-11332	CD	denotes	3
T7727	11332-11333	-RRB-	denotes	)
T7728	11333-11334	.	denotes	.
T7729	11334-11445	sentence	denotes	In addition, the HG2M strain displayed highly significant decreases in length, similar to B62M mice (Table 2).
T7730	11335-11337	IN	denotes	In
T7731	11364-11373	VBD	denotes	displayed
T7732	11338-11346	NN	denotes	addition
T7733	11346-11348	,	denotes	,
T7734	11348-11351	DT	denotes	the
T7735	11357-11363	NN	denotes	strain
T7736	11352-11356	NN	denotes	HG2M
T7737	11374-11380	RB	denotes	highly
T7738	11381-11392	JJ	denotes	significant
T7739	11393-11402	NNS	denotes	decreases
T7740	11403-11405	IN	denotes	in
T7741	11406-11412	NN	denotes	length
T7742	11412-11414	,	denotes	,
T7743	11414-11421	JJ	denotes	similar
T7744	11422-11424	IN	denotes	to
T7745	11425-11429	NN	denotes	B62M
T7746	11430-11434	NNS	denotes	mice
T7747	11435-11436	-LRB-	denotes	(
T7748	11436-11441	NN	denotes	Table
T7749	11442-11443	CD	denotes	2
T7750	11443-11444	-RRB-	denotes	)
T7751	11444-11445	.	denotes	.
T7752	11445-11657	sentence	denotes	These results indicate QTL within Region II shared between the HG2P and HG2PM strains decrease body size, weight gain and NA (only in females), while a QTL in the HG2M region significantly decreases tail length.
T7753	11446-11451	DT	denotes	These
T7754	11452-11459	NNS	denotes	results
T7755	11460-11468	VBP	denotes	indicate
T7756	11469-11472	NN	denotes	QTL
T7757	11532-11540	VBP	denotes	decrease
T7758	11473-11479	IN	denotes	within
T7759	11480-11486	NN	denotes	Region
T7760	11487-11489	CD	denotes	II
T7761	11490-11496	VBN	denotes	shared
T7762	11497-11504	IN	denotes	between
T7763	11505-11508	DT	denotes	the
T7764	11524-11531	NNS	denotes	strains
T7765	11509-11513	NN	denotes	HG2P
T7766	11514-11517	CC	denotes	and
T7767	11518-11523	NN	denotes	HG2PM
T7768	11541-11545	NN	denotes	body
T7769	11546-11550	NN	denotes	size
T7770	11550-11552	,	denotes	,
T7771	11552-11558	NN	denotes	weight
T7772	11559-11563	NN	denotes	gain
T7773	11564-11567	CC	denotes	and
T7774	11568-11570	NN	denotes	NA
T7775	11571-11572	-LRB-	denotes	(
T7776	11572-11576	RB	denotes	only
T7777	11577-11579	IN	denotes	in
T7778	11580-11587	NNS	denotes	females
T7779	11587-11588	-RRB-	denotes	)
T7780	11588-11590	,	denotes	,
T7781	11590-11595	IN	denotes	while
T7782	11635-11644	VBZ	denotes	decreases
T7783	11596-11597	DT	denotes	a
T7784	11598-11601	NN	denotes	QTL
T7785	11602-11604	IN	denotes	in
T7786	11605-11608	DT	denotes	the
T7787	11614-11620	NN	denotes	region
T7788	11609-11613	NN	denotes	HG2M
T7789	11621-11634	RB	denotes	significantly
T7790	11645-11649	NN	denotes	tail
T7791	11650-11656	NN	denotes	length
T7792	11656-11657	.	denotes	.
T7793	11657-11785	sentence	denotes	Similar to growth traits a general decrease in GFP, MFP, RFP, TF and AI were seen in HG2P and HG2PM mice (Region II) (Table 2).
T7794	11658-11665	JJ	denotes	Similar
T7795	11735-11739	VBN	denotes	seen
T7796	11666-11668	IN	denotes	to
T7797	11669-11675	NN	denotes	growth
T7798	11676-11682	NNS	denotes	traits
T7799	11683-11684	DT	denotes	a
T7800	11693-11701	NN	denotes	decrease
T7801	11685-11692	JJ	denotes	general
T7802	11702-11704	IN	denotes	in
T7803	11705-11708	NN	denotes	GFP
T7804	11708-11710	,	denotes	,
T7805	11710-11713	NN	denotes	MFP
T7806	11713-11715	,	denotes	,
T7807	11715-11718	NN	denotes	RFP
T7808	11718-11720	,	denotes	,
T7809	11720-11722	NN	denotes	TF
T7810	11723-11726	CC	denotes	and
T7811	11727-11729	NN	denotes	AI
T7812	11730-11734	VBD	denotes	were
T7813	11740-11742	IN	denotes	in
T7814	11743-11747	NN	denotes	HG2P
T7815	11758-11762	NNS	denotes	mice
T7816	11748-11751	CC	denotes	and
T7817	11752-11757	NN	denotes	HG2PM
T7818	11763-11764	-LRB-	denotes	(
T7819	11764-11770	NN	denotes	Region
T7820	11771-11773	CD	denotes	II
T7821	11773-11774	-RRB-	denotes	)
T7822	11775-11776	-LRB-	denotes	(
T7823	11776-11781	NN	denotes	Table
T7824	11782-11783	CD	denotes	2
T7825	11783-11784	-RRB-	denotes	)
T7826	11784-11785	.	denotes	.
T7827	11785-11899	sentence	denotes	These differences in adiposity are likely pleiotropic effects of the growth QTL shared between these two strains.
T7828	11786-11791	DT	denotes	These
T7829	11792-11803	NNS	denotes	differences
T7830	11817-11820	VBP	denotes	are
T7831	11804-11806	IN	denotes	in
T7832	11807-11816	NN	denotes	adiposity
T7833	11821-11827	RB	denotes	likely
T7834	11828-11839	JJ	denotes	pleiotropic
T7835	11840-11847	NNS	denotes	effects
T7836	11848-11850	IN	denotes	of
T7837	11851-11854	DT	denotes	the
T7838	11862-11865	NN	denotes	QTL
T7839	11855-11861	NN	denotes	growth
T7840	11866-11872	VBN	denotes	shared
T7841	11873-11880	IN	denotes	between
T7842	11881-11886	DT	denotes	these
T7843	11891-11898	NNS	denotes	strains
T7844	11887-11890	CD	denotes	two
T7845	11898-11899	.	denotes	.
T7846	11899-11972	sentence	denotes	Surprisingly, HG2M mice displayed striking sex differences in adiposity.
T7847	11900-11912	RB	denotes	Surprisingly
T7848	11924-11933	VBD	denotes	displayed
T7849	11912-11914	,	denotes	,
T7850	11914-11918	NN	denotes	HG2M
T7851	11919-11923	NNS	denotes	mice
T7852	11934-11942	JJ	denotes	striking
T7853	11947-11958	NNS	denotes	differences
T7854	11943-11946	NN	denotes	sex
T7855	11959-11961	IN	denotes	in
T7856	11962-11971	NN	denotes	adiposity
T7857	11971-11972	.	denotes	.
T7858	11972-12143	sentence	denotes	Males exhibited an increase in AI (P = 0.0256) with a decrease in BMI (P = 0.0462) and the exact opposite was seen in females (AI, P < 0.0001; BMI, P = 0.0425) (Table 2).
T7859	11973-11978	NNS	denotes	Males
T7860	11979-11988	VBD	denotes	exhibited
T7861	11989-11991	DT	denotes	an
T7862	11992-12000	NN	denotes	increase
T7863	12001-12003	IN	denotes	in
T7864	12004-12006	NN	denotes	AI
T7865	12007-12008	-LRB-	denotes	(
T7866	12012-12018	CD	denotes	0.0256
T7867	12008-12009	NN	denotes	P
T7868	12010-12011	SYM	denotes	=
T7869	12018-12019	-RRB-	denotes	)
T7870	12020-12024	IN	denotes	with
T7871	12025-12026	DT	denotes	a
T7872	12027-12035	NN	denotes	decrease
T7873	12036-12038	IN	denotes	in
T7874	12039-12042	NN	denotes	BMI
T7875	12043-12044	-LRB-	denotes	(
T7876	12048-12054	CD	denotes	0.0462
T7877	12044-12045	NN	denotes	P
T7878	12046-12047	SYM	denotes	=
T7879	12054-12055	-RRB-	denotes	)
T7880	12056-12059	CC	denotes	and
T7881	12060-12063	DT	denotes	the
T7882	12070-12078	NN	denotes	opposite
T7883	12064-12069	JJ	denotes	exact
T7884	12083-12087	VBN	denotes	seen
T7885	12079-12082	VBD	denotes	was
T7886	12088-12090	IN	denotes	in
T7887	12091-12098	NNS	denotes	females
T7888	12099-12100	-LRB-	denotes	(
T7889	12125-12131	CD	denotes	0.0425
T7890	12100-12102	NN	denotes	AI
T7891	12108-12114	CD	denotes	0.0001
T7892	12102-12104	,	denotes	,
T7893	12104-12105	NN	denotes	P
T7894	12106-12107	SYM	denotes	<
T7895	12114-12115	:	denotes	;
T7896	12116-12119	NN	denotes	BMI
T7897	12119-12121	,	denotes	,
T7898	12121-12122	NN	denotes	P
T7899	12123-12124	SYM	denotes	=
T7900	12131-12132	-RRB-	denotes	)
T7901	12133-12134	-LRB-	denotes	(
T7902	12134-12139	NN	denotes	Table
T7903	12140-12141	CD	denotes	2
T7904	12141-12142	-RRB-	denotes	)
T7905	12142-12143	.	denotes	.
T7906	12143-12254	sentence	denotes	Therefore, the obesity QTL in the HG2M unique region (Region IV) is profoundly impacted by the presence of hg.
T7907	12144-12153	RB	denotes	Therefore
T7908	12223-12231	VBN	denotes	impacted
T7909	12153-12155	,	denotes	,
T7910	12155-12158	DT	denotes	the
T7911	12167-12170	NN	denotes	QTL
T7912	12159-12166	NN	denotes	obesity
T7913	12171-12173	IN	denotes	in
T7914	12174-12177	DT	denotes	the
T7915	12190-12196	NN	denotes	region
T7916	12178-12182	NN	denotes	HG2M
T7917	12183-12189	JJ	denotes	unique
T7918	12197-12198	-LRB-	denotes	(
T7919	12198-12204	NN	denotes	Region
T7920	12205-12207	CD	denotes	IV
T7921	12207-12208	-RRB-	denotes	)
T7922	12209-12211	VBZ	denotes	is
T7923	12212-12222	RB	denotes	profoundly
T7924	12232-12234	IN	denotes	by
T7925	12235-12238	DT	denotes	the
T7926	12239-12247	NN	denotes	presence
T7927	12248-12250	IN	denotes	of
T7928	12251-12253	NN	denotes	hg
T7929	12253-12254	.	denotes	.
T7930	12254-12291	sentence	denotes	Confirmation of QTL-hg interactions
T7931	12256-12268	NN	denotes	Confirmation
T7932	12269-12271	IN	denotes	of
T7933	12272-12275	NN	denotes	QTL
T7934	12276-12278	NN	denotes	hg
T7935	12275-12276	HYPH	denotes	-
T7936	12279-12291	NNS	denotes	interactions
T7937	12291-12549	sentence	denotes	An important feature of our experimental design was the ability to test for interactions between QTL in each MMU2 donor region and genotype at the HG locus, since identical donor regions were introgressed on two genetic backgrounds, B6 (+/+) and HG (hg/hg).
T7938	12292-12294	DT	denotes	An
T7939	12305-12312	NN	denotes	feature
T7940	12295-12304	JJ	denotes	important
T7941	12340-12343	VBD	denotes	was
T7942	12313-12315	IN	denotes	of
T7943	12316-12319	PRP$	denotes	our
T7944	12333-12339	NN	denotes	design
T7945	12320-12332	JJ	denotes	experimental
T7946	12344-12347	DT	denotes	the
T7947	12348-12355	NN	denotes	ability
T7948	12356-12358	TO	denotes	to
T7949	12359-12363	VB	denotes	test
T7950	12364-12367	IN	denotes	for
T7951	12368-12380	NNS	denotes	interactions
T7952	12381-12388	IN	denotes	between
T7953	12389-12392	NN	denotes	QTL
T7954	12393-12395	IN	denotes	in
T7955	12396-12400	DT	denotes	each
T7956	12412-12418	NN	denotes	region
T7957	12401-12405	NN	denotes	MMU2
T7958	12406-12411	NN	denotes	donor
T7959	12419-12422	CC	denotes	and
T7960	12423-12431	VB	denotes	genotype
T7961	12432-12434	IN	denotes	at
T7962	12435-12438	DT	denotes	the
T7963	12442-12447	NN	denotes	locus
T7964	12439-12441	NN	denotes	HG
T7965	12447-12449	,	denotes	,
T7966	12449-12454	IN	denotes	since
T7967	12484-12496	VBN	denotes	introgressed
T7968	12455-12464	JJ	denotes	identical
T7969	12471-12478	NNS	denotes	regions
T7970	12465-12470	NN	denotes	donor
T7971	12479-12483	VBD	denotes	were
T7972	12497-12499	IN	denotes	on
T7973	12500-12503	CD	denotes	two
T7974	12512-12523	NNS	denotes	backgrounds
T7975	12504-12511	JJ	denotes	genetic
T7976	12523-12525	,	denotes	,
T7977	12525-12527	NN	denotes	B6
T7978	12528-12529	-LRB-	denotes	(
T7979	12531-12532	SYM	denotes	+
T7980	12529-12530	SYM	denotes	+
T7981	12530-12531	HYPH	denotes	/
T7982	12532-12533	-RRB-	denotes	)
T7983	12534-12537	CC	denotes	and
T7984	12538-12540	NN	denotes	HG
T7985	12541-12542	-LRB-	denotes	(
T7986	12545-12547	NN	denotes	hg
T7987	12542-12544	NN	denotes	hg
T7988	12544-12545	HYPH	denotes	/
T7989	12547-12548	-RRB-	denotes	)
T7990	12548-12549	.	denotes	.
T7991	12549-12705	sentence	denotes	Significant interactions between donor region and HG genotype were viewed as strong evidence that hg modifier QTL reside within that unique genomic region.
T7992	12550-12561	JJ	denotes	Significant
T7993	12562-12574	NNS	denotes	interactions
T7994	12617-12623	VBN	denotes	viewed
T7995	12575-12582	IN	denotes	between
T7996	12583-12588	NN	denotes	donor
T7997	12589-12595	NN	denotes	region
T7998	12596-12599	CC	denotes	and
T7999	12600-12602	NN	denotes	HG
T8000	12603-12611	NN	denotes	genotype
T8001	12612-12616	VBD	denotes	were
T8002	12624-12626	IN	denotes	as
T8003	12627-12633	JJ	denotes	strong
T8004	12634-12642	NN	denotes	evidence
T8005	12643-12647	IN	denotes	that
T8006	12664-12670	VBP	denotes	reside
T8007	12648-12650	NN	denotes	hg
T8008	12660-12663	NN	denotes	QTL
T8009	12651-12659	NN	denotes	modifier
T8010	12671-12677	IN	denotes	within
T8011	12678-12682	DT	denotes	that
T8012	12698-12704	NN	denotes	region
T8013	12683-12689	JJ	denotes	unique
T8014	12690-12697	JJ	denotes	genomic
T8015	12704-12705	.	denotes	.
T8016	12705-12840	sentence	denotes	In the original linkage analysis the mode of gene action and peak location of Wg2 were dependent on the presence of hg [24] (Table 1).
T8017	12706-12708	IN	denotes	In
T8018	12788-12792	VBD	denotes	were
T8019	12709-12712	DT	denotes	the
T8020	12730-12738	NN	denotes	analysis
T8021	12713-12721	JJ	denotes	original
T8022	12722-12729	NN	denotes	linkage
T8023	12739-12742	DT	denotes	the
T8024	12743-12747	NN	denotes	mode
T8025	12748-12750	IN	denotes	of
T8026	12751-12755	NN	denotes	gene
T8027	12756-12762	NN	denotes	action
T8028	12763-12766	CC	denotes	and
T8029	12767-12771	JJ	denotes	peak
T8030	12772-12780	NN	denotes	location
T8031	12781-12783	IN	denotes	of
T8032	12784-12787	NN	denotes	Wg2
T8033	12793-12802	JJ	denotes	dependent
T8034	12803-12805	IN	denotes	on
T8035	12806-12809	DT	denotes	the
T8036	12810-12818	NN	denotes	presence
T8037	12819-12821	IN	denotes	of
T8038	12822-12824	NN	denotes	hg
T8039	12825-12826	-LRB-	denotes	[
T8040	12826-12828	CD	denotes	24
T8041	12828-12829	-RRB-	denotes	]
T8042	12830-12831	-LRB-	denotes	(
T8043	12831-12836	NN	denotes	Table
T8044	12837-12838	CD	denotes	1
T8045	12838-12839	-RRB-	denotes	)
T8046	12839-12840	.	denotes	.
T8047	12840-12967	sentence	denotes	In the present study, only homozygous congenic mice were characterized, thus, the overdominant effects of Wg2 were not tested.
T8048	12841-12843	IN	denotes	In
T8049	12960-12966	VBN	denotes	tested
T8050	12844-12847	DT	denotes	the
T8051	12856-12861	NN	denotes	study
T8052	12848-12855	JJ	denotes	present
T8053	12861-12863	,	denotes	,
T8054	12863-12867	RB	denotes	only
T8055	12888-12892	NNS	denotes	mice
T8056	12868-12878	JJ	denotes	homozygous
T8057	12879-12887	JJ	denotes	congenic
T8058	12898-12911	VBN	denotes	characterized
T8059	12893-12897	VBD	denotes	were
T8060	12911-12913	,	denotes	,
T8061	12913-12917	RB	denotes	thus
T8062	12917-12919	,	denotes	,
T8063	12919-12922	DT	denotes	the
T8064	12936-12943	NNS	denotes	effects
T8065	12923-12935	JJ	denotes	overdominant
T8066	12944-12946	IN	denotes	of
T8067	12947-12950	NN	denotes	Wg2
T8068	12951-12955	VBD	denotes	were
T8069	12956-12959	RB	denotes	not
T8070	12966-12967	.	denotes	.
T8071	12967-13208	sentence	denotes	However, since its original peak location differed dependent on background we hypothesized that Wg2 represents a set of linked QTL between 74.9 and 181.8 Mbp within the 2M and 2D donor regions (Region III–V), some of which interact with hg.
T8072	12968-12975	RB	denotes	However
T8073	13046-13058	VBD	denotes	hypothesized
T8074	12975-12977	,	denotes	,
T8075	12977-12982	IN	denotes	since
T8076	13010-13018	VBD	denotes	differed
T8077	12983-12986	PRP$	denotes	its
T8078	13001-13009	NN	denotes	location
T8079	12987-12995	JJ	denotes	original
T8080	12996-13000	NN	denotes	peak
T8081	13019-13028	RB	denotes	dependent
T8082	13029-13031	IN	denotes	on
T8083	13032-13042	NN	denotes	background
T8084	13043-13045	PRP	denotes	we
T8085	13059-13063	IN	denotes	that
T8086	13068-13078	VBZ	denotes	represents
T8087	13064-13067	NN	denotes	Wg2
T8088	13079-13080	DT	denotes	a
T8089	13081-13084	NN	denotes	set
T8090	13085-13087	IN	denotes	of
T8091	13088-13094	VBN	denotes	linked
T8092	13095-13098	NN	denotes	QTL
T8093	13099-13106	IN	denotes	between
T8094	13107-13111	CD	denotes	74.9
T8095	13122-13125	NN	denotes	Mbp
T8096	13112-13115	CC	denotes	and
T8097	13116-13121	CD	denotes	181.8
T8098	13126-13132	IN	denotes	within
T8099	13133-13136	DT	denotes	the
T8100	13153-13160	NNS	denotes	regions
T8101	13137-13139	NN	denotes	2M
T8102	13140-13143	CC	denotes	and
T8103	13144-13146	NN	denotes	2D
T8104	13147-13152	NN	denotes	donor
T8105	13161-13162	-LRB-	denotes	(
T8106	13162-13168	NN	denotes	Region
T8107	13169-13172	CD	denotes	III
T8108	13172-13173	SYM	denotes	–
T8109	13173-13174	CD	denotes	V
T8110	13174-13175	-RRB-	denotes	)
T8111	13175-13177	,	denotes	,
T8112	13177-13181	DT	denotes	some
T8113	13191-13199	VBP	denotes	interact
T8114	13182-13184	IN	denotes	of
T8115	13185-13190	WDT	denotes	which
T8116	13200-13204	IN	denotes	with
T8117	13205-13207	NN	denotes	hg
T8118	13207-13208	.	denotes	.
T8119	13208-13326	sentence	denotes	Following this logic we expected one or both of these strains would exhibit donor region by HG genotype interactions.
T8120	13209-13218	VBG	denotes	Following
T8121	13233-13241	VBD	denotes	expected
T8122	13219-13223	DT	denotes	this
T8123	13224-13229	NN	denotes	logic
T8124	13230-13232	PRP	denotes	we
T8125	13242-13245	CD	denotes	one
T8126	13277-13284	VB	denotes	exhibit
T8127	13246-13248	CC	denotes	or
T8128	13249-13253	DT	denotes	both
T8129	13254-13256	IN	denotes	of
T8130	13257-13262	DT	denotes	these
T8131	13263-13270	NNS	denotes	strains
T8132	13271-13276	MD	denotes	would
T8133	13285-13290	NN	denotes	donor
T8134	13291-13297	NN	denotes	region
T8135	13313-13325	NNS	denotes	interactions
T8136	13298-13300	IN	denotes	by
T8137	13301-13303	NN	denotes	HG
T8138	13304-13312	NN	denotes	genotype
T8139	13325-13326	.	denotes	.
T8140	13326-13383	sentence	denotes	Unfortunately, we were unable to characterize HG2D mice.
T8141	13327-13340	RB	denotes	Unfortunately
T8142	13345-13349	VBD	denotes	were
T8143	13340-13342	,	denotes	,
T8144	13342-13344	PRP	denotes	we
T8145	13350-13356	JJ	denotes	unable
T8146	13357-13359	TO	denotes	to
T8147	13360-13372	VB	denotes	characterize
T8148	13373-13377	NN	denotes	HG2D
T8149	13378-13382	NNS	denotes	mice
T8150	13382-13383	.	denotes	.
T8151	13383-13460	sentence	denotes	However, as noted above, strong sex-specific effects were seen in HG2M mice.
T8152	13384-13391	RB	denotes	However
T8153	13442-13446	VBN	denotes	seen
T8154	13391-13393	,	denotes	,
T8155	13393-13395	IN	denotes	as
T8156	13396-13401	VBN	denotes	noted
T8157	13402-13407	RB	denotes	above
T8158	13407-13409	,	denotes	,
T8159	13409-13415	JJ	denotes	strong
T8160	13429-13436	NNS	denotes	effects
T8161	13416-13419	NN	denotes	sex
T8162	13420-13428	JJ	denotes	specific
T8163	13419-13420	HYPH	denotes	-
T8164	13437-13441	VBD	denotes	were
T8165	13447-13449	IN	denotes	in
T8166	13450-13454	NN	denotes	HG2M
T8167	13455-13459	NNS	denotes	mice
T8168	13459-13460	.	denotes	.
T8169	13460-13597	sentence	denotes	Significant 2M donor region by HG genotype by sex three-way interactions for AI (P = 0.0004; Figure 4) and TF were identified (Table 3).
T8170	13461-13472	JJ	denotes	Significant
T8171	13521-13533	NNS	denotes	interactions
T8172	13473-13475	NN	denotes	2M
T8173	13482-13488	NN	denotes	region
T8174	13476-13481	NN	denotes	donor
T8175	13489-13491	IN	denotes	by
T8176	13492-13494	NN	denotes	HG
T8177	13495-13503	NN	denotes	genotype
T8178	13504-13506	IN	denotes	by
T8179	13507-13510	NN	denotes	sex
T8180	13511-13516	CD	denotes	three
T8181	13517-13520	NN	denotes	way
T8182	13516-13517	HYPH	denotes	-
T8183	13576-13586	VBN	denotes	identified
T8184	13534-13537	IN	denotes	for
T8185	13538-13540	NN	denotes	AI
T8186	13541-13542	-LRB-	denotes	(
T8187	13554-13560	NN	denotes	Figure
T8188	13542-13543	NN	denotes	P
T8189	13546-13552	CD	denotes	0.0004
T8190	13544-13545	SYM	denotes	=
T8191	13552-13553	:	denotes	;
T8192	13561-13562	CD	denotes	4
T8193	13562-13563	-RRB-	denotes	)
T8194	13564-13567	CC	denotes	and
T8195	13568-13570	NN	denotes	TF
T8196	13571-13575	VBD	denotes	were
T8197	13587-13588	-LRB-	denotes	(
T8198	13588-13593	NN	denotes	Table
T8199	13594-13595	CD	denotes	3
T8200	13595-13596	-RRB-	denotes	)
T8201	13596-13597	.	denotes	.
T8202	13597-13758	sentence	denotes	The basis of these interactions was a decrease in HG2M female and an increase in HG2M male adiposity, with no differences in fat accumulation across B62M sexes.
T8203	13598-13601	DT	denotes	The
T8204	13602-13607	NN	denotes	basis
T8205	13630-13633	VBD	denotes	was
T8206	13608-13610	IN	denotes	of
T8207	13611-13616	DT	denotes	these
T8208	13617-13629	NNS	denotes	interactions
T8209	13634-13635	DT	denotes	a
T8210	13636-13644	NN	denotes	decrease
T8211	13645-13647	IN	denotes	in
T8212	13648-13652	NN	denotes	HG2M
T8213	13653-13659	NN	denotes	female
T8214	13660-13663	CC	denotes	and
T8215	13664-13666	DT	denotes	an
T8216	13667-13675	NN	denotes	increase
T8217	13689-13698	NN	denotes	adiposity
T8218	13676-13678	IN	denotes	in
T8219	13679-13683	NN	denotes	HG2M
T8220	13684-13688	JJ	denotes	male
T8221	13698-13700	,	denotes	,
T8222	13700-13704	IN	denotes	with
T8223	13705-13707	DT	denotes	no
T8224	13708-13719	NNS	denotes	differences
T8225	13720-13722	IN	denotes	in
T8226	13723-13726	NN	denotes	fat
T8227	13727-13739	NN	denotes	accumulation
T8228	13740-13746	IN	denotes	across
T8229	13747-13751	NN	denotes	B62M
T8230	13752-13757	NNS	denotes	sexes
T8231	13757-13758	.	denotes	.
T8232	13758-13916	sentence	denotes	Significant 2PM donor region by HG genotype two-way and 2PM donor region by HG genotype by sex three-way interactions were also seen for TF and AI (Table 3).
T8233	13759-13770	JJ	denotes	Significant
T8234	13864-13876	NNS	denotes	interactions
T8235	13771-13774	NN	denotes	2PM
T8236	13781-13787	NN	denotes	region
T8237	13775-13780	NN	denotes	donor
T8238	13807-13810	NN	denotes	way
T8239	13788-13790	IN	denotes	by
T8240	13791-13793	NN	denotes	HG
T8241	13794-13802	NN	denotes	genotype
T8242	13803-13806	CD	denotes	two
T8243	13806-13807	HYPH	denotes	-
T8244	13811-13814	CC	denotes	and
T8245	13815-13818	NN	denotes	2PM
T8246	13825-13831	NN	denotes	region
T8247	13819-13824	NN	denotes	donor
T8248	13860-13863	NN	denotes	way
T8249	13832-13834	IN	denotes	by
T8250	13835-13837	NN	denotes	HG
T8251	13838-13846	NN	denotes	genotype
T8252	13847-13849	IN	denotes	by
T8253	13850-13853	NN	denotes	sex
T8254	13854-13859	CD	denotes	three
T8255	13859-13860	HYPH	denotes	-
T8256	13887-13891	VBN	denotes	seen
T8257	13877-13881	VBD	denotes	were
T8258	13882-13886	RB	denotes	also
T8259	13892-13895	IN	denotes	for
T8260	13896-13898	NN	denotes	TF
T8261	13899-13902	CC	denotes	and
T8262	13903-13905	NN	denotes	AI
T8263	13906-13907	-LRB-	denotes	(
T8264	13907-13912	NN	denotes	Table
T8265	13913-13914	CD	denotes	3
T8266	13914-13915	-RRB-	denotes	)
T8267	13915-13916	.	denotes	.
T8268	13916-14105	sentence	denotes	In addition, significant 2P donor region × HG genotype interactions were observed for all traits listed, although some traits did reached significance at the critical P < 0.0071 (Table 3).
T8269	13917-13919	IN	denotes	In
T8270	13990-13998	VBN	denotes	observed
T8271	13920-13928	NN	denotes	addition
T8272	13928-13930	,	denotes	,
T8273	13930-13941	JJ	denotes	significant
T8274	13972-13984	NNS	denotes	interactions
T8275	13942-13944	NN	denotes	2P
T8276	13951-13957	NN	denotes	region
T8277	13945-13950	NN	denotes	donor
T8278	13958-13959	SYM	denotes	×
T8279	13963-13971	NN	denotes	genotype
T8280	13960-13962	NN	denotes	HG
T8281	13985-13989	VBD	denotes	were
T8282	13999-14002	IN	denotes	for
T8283	14003-14006	DT	denotes	all
T8284	14007-14013	NNS	denotes	traits
T8285	14014-14020	VBN	denotes	listed
T8286	14020-14022	,	denotes	,
T8287	14022-14030	IN	denotes	although
T8288	14047-14054	VBN	denotes	reached
T8289	14031-14035	DT	denotes	some
T8290	14036-14042	NNS	denotes	traits
T8291	14043-14046	VBD	denotes	did
T8292	14055-14067	NN	denotes	significance
T8293	14068-14070	IN	denotes	at
T8294	14071-14074	DT	denotes	the
T8295	14088-14094	CD	denotes	0.0071
T8296	14075-14083	JJ	denotes	critical
T8297	14084-14085	NN	denotes	P
T8298	14086-14087	SYM	denotes	<
T8299	14095-14096	-LRB-	denotes	(
T8300	14096-14101	NN	denotes	Table
T8301	14102-14103	CD	denotes	3
T8302	14103-14104	-RRB-	denotes	)
T8303	14104-14105	.	denotes	.
T8304	14105-14228	sentence	denotes	The basis for each interaction was a decrease in phenotype in HG2P compared to HGC and no difference between B62P and B6C.
T8305	14106-14109	DT	denotes	The
T8306	14110-14115	NN	denotes	basis
T8307	14137-14140	VBD	denotes	was
T8308	14116-14119	IN	denotes	for
T8309	14120-14124	DT	denotes	each
T8310	14125-14136	NN	denotes	interaction
T8311	14141-14142	DT	denotes	a
T8312	14143-14151	NN	denotes	decrease
T8313	14152-14154	IN	denotes	in
T8314	14155-14164	NN	denotes	phenotype
T8315	14165-14167	IN	denotes	in
T8316	14168-14172	NN	denotes	HG2P
T8317	14173-14181	VBN	denotes	compared
T8318	14182-14184	IN	denotes	to
T8319	14185-14188	NN	denotes	HGC
T8320	14189-14192	CC	denotes	and
T8321	14193-14195	DT	denotes	no
T8322	14196-14206	NN	denotes	difference
T8323	14207-14214	IN	denotes	between
T8324	14215-14219	NN	denotes	B62P
T8325	14220-14223	CC	denotes	and
T8326	14224-14227	NN	denotes	B6C
T8327	14227-14228	.	denotes	.
T8328	14228-14309	sentence	denotes	Together these data confirm that MMU2 QTL modify the effects of the hg deletion.
T8329	14229-14237	RB	denotes	Together
T8330	14249-14256	VBP	denotes	confirm
T8331	14238-14243	DT	denotes	these
T8332	14244-14248	NNS	denotes	data
T8333	14257-14261	IN	denotes	that
T8334	14271-14277	VBP	denotes	modify
T8335	14262-14266	NN	denotes	MMU2
T8336	14267-14270	NN	denotes	QTL
T8337	14278-14281	DT	denotes	the
T8338	14282-14289	NNS	denotes	effects
T8339	14290-14292	IN	denotes	of
T8340	14293-14296	DT	denotes	the
T8341	14300-14308	NN	denotes	deletion
T8342	14297-14299	NN	denotes	hg
T8343	14308-14309	.	denotes	.
T11091	14311-14316	NN	denotes	Speed
T11092	14317-14325	JJ	denotes	congenic
T11093	14326-14333	NNS	denotes	strains
T11094	14334-14337	IN	denotes	for
T11095	14338-14341	NN	denotes	QTL
T11096	14342-14344	IN	denotes	on
T11097	14345-14348	NN	denotes	MMU
T11098	14348-14349	CD	denotes	1
T11099	14349-14351	,	denotes	,
T11100	14351-14352	CD	denotes	8
T11101	14352-14354	,	denotes	,
T11102	14354-14355	CD	denotes	9
T11103	14355-14357	,	denotes	,
T11104	14357-14359	CD	denotes	11
T11105	14360-14363	CC	denotes	and
T11106	14364-14366	CD	denotes	17
T11107	14366-14371	sentence	denotes	HG1
T11108	14368-14371	NN	denotes	HG1
T11109	14371-14548	sentence	denotes	Q1Ucd1 affecting G26 was the least significant of any QTL identified in the original intercross and only reached a suggestive level of significance (LOD = 2.46, P < 0.05) [26].
T11110	14372-14378	NN	denotes	Q1Ucd1
T11111	14393-14396	VBD	denotes	was
T11112	14379-14388	VBG	denotes	affecting
T11113	14389-14392	NN	denotes	G26
T11114	14397-14400	DT	denotes	the
T11115	14407-14418	JJ	denotes	significant
T11116	14401-14406	JJS	denotes	least
T11117	14419-14421	IN	denotes	of
T11118	14422-14425	DT	denotes	any
T11119	14426-14429	NN	denotes	QTL
T11120	14430-14440	VBN	denotes	identified
T11121	14441-14443	IN	denotes	in
T11122	14444-14447	DT	denotes	the
T11123	14457-14467	NN	denotes	intercross
T11124	14448-14456	JJ	denotes	original
T11125	14468-14471	CC	denotes	and
T11126	14472-14476	RB	denotes	only
T11127	14477-14484	VBD	denotes	reached
T11128	14485-14486	DT	denotes	a
T11129	14498-14503	NN	denotes	level
T11130	14487-14497	JJ	denotes	suggestive
T11131	14504-14506	IN	denotes	of
T11132	14507-14519	NN	denotes	significance
T11133	14520-14521	-LRB-	denotes	(
T11134	14537-14541	CD	denotes	0.05
T11135	14521-14524	NN	denotes	LOD
T11136	14527-14531	CD	denotes	2.46
T11137	14525-14526	SYM	denotes	=
T11138	14531-14533	,	denotes	,
T11139	14533-14534	NN	denotes	P
T11140	14535-14536	SYM	denotes	<
T11141	14541-14542	-RRB-	denotes	)
T11142	14543-14544	-LRB-	denotes	[
T11143	14544-14546	CD	denotes	26
T11144	14546-14547	-RRB-	denotes	]
T11145	14547-14548	.	denotes	.
T11146	14548-14627	sentence	denotes	In accordance, HG1 mice had small differences in all growth and length traits.
T11147	14549-14551	IN	denotes	In
T11148	14573-14576	VBD	denotes	had
T11149	14552-14562	NN	denotes	accordance
T11150	14562-14564	,	denotes	,
T11151	14564-14567	NN	denotes	HG1
T11152	14568-14572	NNS	denotes	mice
T11153	14577-14582	JJ	denotes	small
T11154	14583-14594	NNS	denotes	differences
T11155	14595-14597	IN	denotes	in
T11156	14598-14601	DT	denotes	all
T11157	14620-14626	NNS	denotes	traits
T11158	14602-14608	NN	denotes	growth
T11159	14609-14612	CC	denotes	and
T11160	14613-14619	NN	denotes	length
T11161	14626-14627	.	denotes	.
T11162	14627-14740	sentence	denotes	NA in both sexes and 2WK, 3WK, 6WK and tail length in females was significant at a critical P < 0.005 (Table 4).
T11163	14628-14630	NN	denotes	NA
T11164	14690-14693	VBD	denotes	was
T11165	14631-14633	IN	denotes	in
T11166	14634-14638	CC	denotes	both
T11167	14639-14644	NNS	denotes	sexes
T11168	14645-14648	CC	denotes	and
T11169	14649-14652	NN	denotes	2WK
T11170	14659-14662	NN	denotes	6WK
T11171	14652-14654	,	denotes	,
T11172	14654-14657	NN	denotes	3WK
T11173	14657-14659	,	denotes	,
T11174	14663-14666	CC	denotes	and
T11175	14667-14671	NN	denotes	tail
T11176	14672-14678	NN	denotes	length
T11177	14679-14681	IN	denotes	in
T11178	14682-14689	NNS	denotes	females
T11179	14694-14705	JJ	denotes	significant
T11180	14706-14708	IN	denotes	at
T11181	14709-14710	DT	denotes	a
T11182	14724-14729	CD	denotes	0.005
T11183	14711-14719	JJ	denotes	critical
T11184	14720-14721	NN	denotes	P
T11185	14722-14723	SYM	denotes	<
T11186	14730-14731	-LRB-	denotes	(
T11187	14731-14736	NN	denotes	Table
T11188	14737-14738	CD	denotes	4
T11189	14738-14739	-RRB-	denotes	)
T11190	14739-14740	.	denotes	.
T11191	14740-14823	sentence	denotes	The only difference in adiposity was a significant decrease in male MFP (Table 5).
T11192	14741-14744	DT	denotes	The
T11193	14750-14760	NN	denotes	difference
T11194	14745-14749	JJ	denotes	only
T11195	14774-14777	VBD	denotes	was
T11196	14761-14763	IN	denotes	in
T11197	14764-14773	NN	denotes	adiposity
T11198	14778-14779	DT	denotes	a
T11199	14792-14800	NN	denotes	decrease
T11200	14780-14791	JJ	denotes	significant
T11201	14801-14803	IN	denotes	in
T11202	14804-14808	JJ	denotes	male
T11203	14809-14812	NN	denotes	MFP
T11204	14813-14814	-LRB-	denotes	(
T11205	14814-14819	NN	denotes	Table
T11206	14820-14821	CD	denotes	5
T11207	14821-14822	-RRB-	denotes	)
T11208	14822-14823	.	denotes	.
T11209	14823-15004	sentence	denotes	The successful capture and confirmation of the small effect Q1Ucd1-w26 QTL adds support to pursuing QTL identified at suggestive levels of statistical confidence from genome scans.
T11210	14824-14827	DT	denotes	The
T11211	14839-14846	NN	denotes	capture
T11212	14828-14838	JJ	denotes	successful
T11213	14899-14903	VBZ	denotes	adds
T11214	14847-14850	CC	denotes	and
T11215	14851-14863	NN	denotes	confirmation
T11216	14864-14866	IN	denotes	of
T11217	14867-14870	DT	denotes	the
T11218	14895-14898	NN	denotes	QTL
T11219	14871-14876	JJ	denotes	small
T11220	14877-14883	NN	denotes	effect
T11221	14884-14890	NN	denotes	Q1Ucd1
T11222	14891-14894	NN	denotes	w26
T11223	14890-14891	HYPH	denotes	-
T11224	14904-14911	NN	denotes	support
T11225	14912-14914	IN	denotes	to
T11226	14915-14923	VBG	denotes	pursuing
T11227	14924-14927	NN	denotes	QTL
T11228	14928-14938	VBN	denotes	identified
T11229	14939-14941	IN	denotes	at
T11230	14942-14952	JJ	denotes	suggestive
T11231	14953-14959	NNS	denotes	levels
T11232	14960-14962	IN	denotes	of
T11233	14963-14974	JJ	denotes	statistical
T11234	14975-14985	NN	denotes	confidence
T11235	14986-14990	IN	denotes	from
T11236	14991-14997	NN	denotes	genome
T11237	14998-15003	NNS	denotes	scans
T11238	15003-15004	.	denotes	.
T11239	15004-15009	sentence	denotes	HG8
T11240	15006-15009	NN	denotes	HG8
T11241	15009-15079	sentence	denotes	Markers on MMU8 were linked with G29 in the original intercross [24].
T11242	15010-15017	NNS	denotes	Markers
T11243	15031-15037	VBN	denotes	linked
T11244	15018-15020	IN	denotes	on
T11245	15021-15025	NN	denotes	MMU8
T11246	15026-15030	VBD	denotes	were
T11247	15038-15042	IN	denotes	with
T11248	15043-15046	NN	denotes	G29
T11249	15047-15049	IN	denotes	in
T11250	15050-15053	DT	denotes	the
T11251	15063-15073	NN	denotes	intercross
T11252	15054-15062	JJ	denotes	original
T11253	15074-15075	-LRB-	denotes	[
T11254	15075-15077	CD	denotes	24
T11255	15077-15078	-RRB-	denotes	]
T11256	15078-15079	.	denotes	.
T11257	15079-15152	sentence	denotes	This QTL was small, only accounting for 4.3% of the phenotypic variance.
T11258	15080-15084	DT	denotes	This
T11259	15085-15088	NN	denotes	QTL
T11260	15089-15092	VBD	denotes	was
T11261	15093-15098	JJ	denotes	small
T11262	15098-15100	,	denotes	,
T11263	15100-15104	RB	denotes	only
T11264	15105-15115	VBG	denotes	accounting
T11265	15116-15119	IN	denotes	for
T11266	15120-15123	CD	denotes	4.3
T11267	15123-15124	NN	denotes	%
T11268	15125-15127	IN	denotes	of
T11269	15128-15131	DT	denotes	the
T11270	15143-15151	NN	denotes	variance
T11271	15132-15142	JJ	denotes	phenotypic
T11272	15151-15152	.	denotes	.
T11273	15152-15284	sentence	denotes	Interestingly, in HG8 mice no differences in growth were detected; however, they were significantly leaner than controls (Table 5).
T11274	15153-15166	RB	denotes	Interestingly
T11275	15210-15218	VBN	denotes	detected
T11276	15166-15168	,	denotes	,
T11277	15168-15170	IN	denotes	in
T11278	15171-15174	NN	denotes	HG8
T11279	15175-15179	NNS	denotes	mice
T11280	15180-15182	DT	denotes	no
T11281	15183-15194	NNS	denotes	differences
T11282	15195-15197	IN	denotes	in
T11283	15198-15204	NN	denotes	growth
T11284	15205-15209	VBD	denotes	were
T11285	15234-15238	VBD	denotes	were
T11286	15218-15219	:	denotes	;
T11287	15220-15227	RB	denotes	however
T11288	15227-15229	,	denotes	,
T11289	15229-15233	PRP	denotes	they
T11290	15239-15252	RB	denotes	significantly
T11291	15253-15259	JJR	denotes	leaner
T11292	15260-15264	IN	denotes	than
T11293	15265-15273	NNS	denotes	controls
T11294	15274-15275	-LRB-	denotes	(
T11295	15275-15280	NN	denotes	Table
T11296	15281-15282	CD	denotes	5
T11297	15282-15283	-RRB-	denotes	)
T11298	15283-15284	.	denotes	.
T11299	15284-15412	sentence	denotes	In males a general decrease in fat pad mass, TF and AI was detected; however, only MFP was significant at a critical P < 0.005.
T11300	15285-15287	IN	denotes	In
T11301	15372-15375	VBD	denotes	was
T11302	15288-15293	NNS	denotes	males
T11303	15294-15295	DT	denotes	a
T11304	15304-15312	NN	denotes	decrease
T11305	15296-15303	JJ	denotes	general
T11306	15344-15352	VBN	denotes	detected
T11307	15313-15315	IN	denotes	in
T11308	15316-15319	NN	denotes	fat
T11309	15320-15323	NN	denotes	pad
T11310	15324-15328	NN	denotes	mass
T11311	15328-15330	,	denotes	,
T11312	15330-15332	NN	denotes	TF
T11313	15333-15336	CC	denotes	and
T11314	15337-15339	NN	denotes	AI
T11315	15340-15343	VBD	denotes	was
T11316	15352-15353	:	denotes	;
T11317	15354-15361	RB	denotes	however
T11318	15361-15363	,	denotes	,
T11319	15363-15367	RB	denotes	only
T11320	15368-15371	NN	denotes	MFP
T11321	15376-15387	JJ	denotes	significant
T11322	15388-15390	IN	denotes	at
T11323	15391-15392	DT	denotes	a
T11324	15406-15411	CD	denotes	0.005
T11325	15393-15401	JJ	denotes	critical
T11326	15402-15403	NN	denotes	P
T11327	15404-15405	SYM	denotes	<
T11328	15411-15412	.	denotes	.
T11329	15412-15468	sentence	denotes	Male AI was nearly significant at a nominal P = 0.0082.
T11330	15413-15417	JJ	denotes	Male
T11331	15418-15420	NN	denotes	AI
T11332	15421-15424	VBD	denotes	was
T11333	15425-15431	RB	denotes	nearly
T11334	15432-15443	JJ	denotes	significant
T11335	15444-15446	IN	denotes	at
T11336	15447-15448	DT	denotes	a
T11337	15461-15467	CD	denotes	0.0082
T11338	15449-15456	JJ	denotes	nominal
T11339	15457-15458	NN	denotes	P
T11340	15459-15460	SYM	denotes	=
T11341	15467-15468	.	denotes	.
T11342	15468-15580	sentence	denotes	Larger decreases in fat mass were seen in HG8 females, with significant decreases detected for GFP, MFP and AI.
T11343	15469-15475	JJR	denotes	Larger
T11344	15476-15485	NNS	denotes	decreases
T11345	15503-15507	VBN	denotes	seen
T11346	15486-15488	IN	denotes	in
T11347	15489-15492	NN	denotes	fat
T11348	15493-15497	NN	denotes	mass
T11349	15498-15502	VBD	denotes	were
T11350	15508-15510	IN	denotes	in
T11351	15511-15514	NN	denotes	HG8
T11352	15515-15522	NNS	denotes	females
T11353	15522-15524	,	denotes	,
T11354	15524-15528	IN	denotes	with
T11355	15551-15559	VBN	denotes	detected
T11356	15529-15540	JJ	denotes	significant
T11357	15541-15550	NNS	denotes	decreases
T11358	15560-15563	IN	denotes	for
T11359	15564-15567	NN	denotes	GFP
T11360	15567-15569	,	denotes	,
T11361	15569-15572	NN	denotes	MFP
T11362	15573-15576	CC	denotes	and
T11363	15577-15579	NN	denotes	AI
T11364	15579-15580	.	denotes	.
T11365	15580-15687	sentence	denotes	Additionally, RFP and TF were nearly significant with nominal P values of 0.0208 and 0.0153, respectively.
T11366	15581-15593	RB	denotes	Additionally
T11367	15606-15610	VBD	denotes	were
T11368	15593-15595	,	denotes	,
T11369	15595-15598	NN	denotes	RFP
T11370	15599-15602	CC	denotes	and
T11371	15603-15605	NN	denotes	TF
T11372	15611-15617	RB	denotes	nearly
T11373	15618-15629	JJ	denotes	significant
T11374	15630-15634	IN	denotes	with
T11375	15635-15642	JJ	denotes	nominal
T11376	15645-15651	NNS	denotes	values
T11377	15643-15644	NN	denotes	P
T11378	15652-15654	IN	denotes	of
T11379	15655-15661	CD	denotes	0.0208
T11380	15662-15665	CC	denotes	and
T11381	15666-15672	CD	denotes	0.0153
T11382	15672-15674	,	denotes	,
T11383	15674-15686	RB	denotes	respectively
T11384	15686-15687	.	denotes	.
T11385	15687-15784	sentence	denotes	HG8 mice represent a lean congenic model in which CAST alleles protect against fat accumulation.
T11386	15688-15691	NN	denotes	HG8
T11387	15692-15696	NNS	denotes	mice
T11388	15697-15706	VBP	denotes	represent
T11389	15707-15708	DT	denotes	a
T11390	15723-15728	NN	denotes	model
T11391	15709-15713	JJ	denotes	lean
T11392	15714-15722	JJ	denotes	congenic
T11393	15729-15731	IN	denotes	in
T11394	15751-15758	VBP	denotes	protect
T11395	15732-15737	WDT	denotes	which
T11396	15738-15742	NN	denotes	CAST
T11397	15743-15750	NNS	denotes	alleles
T11398	15759-15766	IN	denotes	against
T11399	15767-15770	NN	denotes	fat
T11400	15771-15783	NN	denotes	accumulation
T11401	15783-15784	.	denotes	.
T11402	15784-15789	sentence	denotes	HG9
T11403	15786-15789	NN	denotes	HG9
T11404	15789-15945	sentence	denotes	CAST alleles in the proximal region of MMU9 were previously found to be linked with an increase in body fat percentage and a decrease in femur length [24].
T11405	15790-15794	NN	denotes	CAST
T11406	15795-15802	NNS	denotes	alleles
T11407	15850-15855	VBN	denotes	found
T11408	15803-15805	IN	denotes	in
T11409	15806-15809	DT	denotes	the
T11410	15819-15825	NN	denotes	region
T11411	15810-15818	JJ	denotes	proximal
T11412	15826-15828	IN	denotes	of
T11413	15829-15833	NN	denotes	MMU9
T11414	15834-15838	VBD	denotes	were
T11415	15839-15849	RB	denotes	previously
T11416	15856-15858	TO	denotes	to
T11417	15862-15868	VBN	denotes	linked
T11418	15859-15861	VB	denotes	be
T11419	15869-15873	IN	denotes	with
T11420	15874-15876	DT	denotes	an
T11421	15877-15885	NN	denotes	increase
T11422	15886-15888	IN	denotes	in
T11423	15889-15893	NN	denotes	body
T11424	15894-15897	NN	denotes	fat
T11425	15898-15908	NN	denotes	percentage
T11426	15909-15912	CC	denotes	and
T11427	15913-15914	DT	denotes	a
T11428	15915-15923	NN	denotes	decrease
T11429	15924-15926	IN	denotes	in
T11430	15927-15932	NN	denotes	femur
T11431	15933-15939	NN	denotes	length
T11432	15940-15941	-LRB-	denotes	[
T11433	15941-15943	CD	denotes	24
T11434	15943-15944	-RRB-	denotes	]
T11435	15944-15945	.	denotes	.
T11436	15945-16103	sentence	denotes	The effects appeared to be the result of two linked QTL, Carfhg2 at 10 cM and Feml2 at 20 cM, instead of one pleiotropically impacting both traits (Table 1).
T11437	15946-15949	DT	denotes	The
T11438	15950-15957	NNS	denotes	effects
T11439	15958-15966	VBD	denotes	appeared
T11440	15967-15969	TO	denotes	to
T11441	15970-15972	VB	denotes	be
T11442	15973-15976	DT	denotes	the
T11443	15977-15983	NN	denotes	result
T11444	15984-15986	IN	denotes	of
T11445	15987-15990	CD	denotes	two
T11446	15998-16001	NN	denotes	QTL
T11447	15991-15997	VBN	denotes	linked
T11448	16001-16003	,	denotes	,
T11449	16003-16010	NN	denotes	Carfhg2
T11450	16011-16013	IN	denotes	at
T11451	16014-16016	CD	denotes	10
T11452	16017-16019	NN	denotes	cM
T11453	16020-16023	CC	denotes	and
T11454	16024-16029	NN	denotes	Feml2
T11455	16030-16032	IN	denotes	at
T11456	16033-16035	CD	denotes	20
T11457	16036-16038	NN	denotes	cM
T11458	16038-16040	,	denotes	,
T11459	16040-16047	IN	denotes	instead
T11460	16048-16050	IN	denotes	of
T11461	16051-16054	CD	denotes	one
T11462	16055-16070	RB	denotes	pleiotropically
T11463	16071-16080	VBG	denotes	impacting
T11464	16081-16085	DT	denotes	both
T11465	16086-16092	NNS	denotes	traits
T11466	16093-16094	-LRB-	denotes	(
T11467	16094-16099	NN	denotes	Table
T11468	16100-16101	CD	denotes	1
T11469	16101-16102	-RRB-	denotes	)
T11470	16102-16103	.	denotes	.
T11471	16103-16216	sentence	denotes	In support of this, the increase in fat was dependent on hg; however, differences in femur length were not [24].
T11472	16104-16106	IN	denotes	In
T11473	16144-16147	VBD	denotes	was
T11474	16107-16114	NN	denotes	support
T11475	16115-16117	IN	denotes	of
T11476	16118-16122	DT	denotes	this
T11477	16122-16124	,	denotes	,
T11478	16124-16127	DT	denotes	the
T11479	16128-16136	NN	denotes	increase
T11480	16137-16139	IN	denotes	in
T11481	16140-16143	NN	denotes	fat
T11482	16202-16206	VBD	denotes	were
T11483	16148-16157	JJ	denotes	dependent
T11484	16158-16160	IN	denotes	on
T11485	16161-16163	NN	denotes	hg
T11486	16163-16164	:	denotes	;
T11487	16165-16172	RB	denotes	however
T11488	16172-16174	,	denotes	,
T11489	16174-16185	NNS	denotes	differences
T11490	16186-16188	IN	denotes	in
T11491	16189-16194	NN	denotes	femur
T11492	16195-16201	NN	denotes	length
T11493	16207-16210	RB	denotes	not
T11494	16211-16212	-LRB-	denotes	[
T11495	16212-16214	CD	denotes	24
T11496	16214-16215	-RRB-	denotes	]
T11497	16215-16216	.	denotes	.
T11498	16216-16375	sentence	denotes	In confirmation of Carfhg2 all measures of adiposity in HG9 mice were increased relative to control mice; except MFP in both sexes and BMI in males (Table 5).
T11499	16217-16219	IN	denotes	In
T11500	16287-16296	VBN	denotes	increased
T11501	16220-16232	NN	denotes	confirmation
T11502	16233-16235	IN	denotes	of
T11503	16236-16243	NN	denotes	Carfhg2
T11504	16244-16247	DT	denotes	all
T11505	16248-16256	NNS	denotes	measures
T11506	16257-16259	IN	denotes	of
T11507	16260-16269	NN	denotes	adiposity
T11508	16270-16272	IN	denotes	in
T11509	16273-16276	NN	denotes	HG9
T11510	16277-16281	NNS	denotes	mice
T11511	16282-16286	VBD	denotes	were
T11512	16297-16305	JJ	denotes	relative
T11513	16306-16308	IN	denotes	to
T11514	16309-16316	NN	denotes	control
T11515	16317-16321	NNS	denotes	mice
T11516	16321-16322	:	denotes	;
T11517	16323-16329	IN	denotes	except
T11518	16330-16333	NN	denotes	MFP
T11519	16334-16336	IN	denotes	in
T11520	16337-16341	CC	denotes	both
T11521	16342-16347	NNS	denotes	sexes
T11522	16348-16351	CC	denotes	and
T11523	16352-16355	NN	denotes	BMI
T11524	16356-16358	IN	denotes	in
T11525	16359-16364	NNS	denotes	males
T11526	16365-16366	-LRB-	denotes	(
T11527	16366-16371	NN	denotes	Table
T11528	16372-16373	CD	denotes	5
T11529	16373-16374	-RRB-	denotes	)
T11530	16374-16375	.	denotes	.
T11531	16375-16469	sentence	denotes	In males, GFP, RFP, FFP and AI were increased by 29.0%, 51.2%, 42.9% and 30.0%, respectively.
T11532	16376-16378	IN	denotes	In
T11533	16412-16421	VBN	denotes	increased
T11534	16379-16384	NNS	denotes	males
T11535	16384-16386	,	denotes	,
T11536	16386-16389	NN	denotes	GFP
T11537	16389-16391	,	denotes	,
T11538	16391-16394	NN	denotes	RFP
T11539	16394-16396	,	denotes	,
T11540	16396-16399	NN	denotes	FFP
T11541	16400-16403	CC	denotes	and
T11542	16404-16406	NN	denotes	AI
T11543	16407-16411	VBD	denotes	were
T11544	16422-16424	IN	denotes	by
T11545	16425-16429	CD	denotes	29.0
T11546	16429-16430	NN	denotes	%
T11547	16430-16432	,	denotes	,
T11548	16432-16436	CD	denotes	51.2
T11549	16436-16437	NN	denotes	%
T11550	16437-16439	,	denotes	,
T11551	16439-16443	CD	denotes	42.9
T11552	16443-16444	NN	denotes	%
T11553	16445-16448	CC	denotes	and
T11554	16449-16453	CD	denotes	30.0
T11555	16453-16454	NN	denotes	%
T11556	16454-16456	,	denotes	,
T11557	16456-16468	RB	denotes	respectively
T11558	16468-16469	.	denotes	.
T11559	16469-16514	sentence	denotes	In females these increases were much larger.
T11560	16470-16472	IN	denotes	In
T11561	16497-16501	VBD	denotes	were
T11562	16473-16480	NNS	denotes	females
T11563	16481-16486	DT	denotes	these
T11564	16487-16496	NNS	denotes	increases
T11565	16502-16506	RB	denotes	much
T11566	16507-16513	JJR	denotes	larger
T11567	16513-16514	.	denotes	.
T11568	16514-16610	sentence	denotes	The same measurements were increased by 68.8%, 99.4%, 69.7% and 57.3%, relative to HGC females.
T11569	16515-16518	DT	denotes	The
T11570	16524-16536	NNS	denotes	measurements
T11571	16519-16523	JJ	denotes	same
T11572	16542-16551	VBN	denotes	increased
T11573	16537-16541	VBD	denotes	were
T11574	16552-16554	IN	denotes	by
T11575	16555-16559	CD	denotes	68.8
T11576	16559-16560	NN	denotes	%
T11577	16560-16562	,	denotes	,
T11578	16562-16566	CD	denotes	99.4
T11579	16566-16567	NN	denotes	%
T11580	16567-16569	,	denotes	,
T11581	16569-16573	CD	denotes	69.7
T11582	16573-16574	NN	denotes	%
T11583	16575-16578	CC	denotes	and
T11584	16579-16583	CD	denotes	57.3
T11585	16583-16584	NN	denotes	%
T11586	16584-16586	,	denotes	,
T11587	16586-16594	JJ	denotes	relative
T11588	16595-16597	IN	denotes	to
T11589	16598-16601	NN	denotes	HGC
T11590	16602-16609	NNS	denotes	females
T11591	16609-16610	.	denotes	.
T11592	16610-16692	sentence	denotes	A 2.9% and 3.6% reduction in male and female NA, respectively, was also detected.
T11593	16611-16612	DT	denotes	A
T11594	16627-16636	NN	denotes	reduction
T11595	16613-16616	CD	denotes	2.9
T11596	16616-16617	NN	denotes	%
T11597	16618-16621	CC	denotes	and
T11598	16622-16625	CD	denotes	3.6
T11599	16625-16626	NN	denotes	%
T11600	16683-16691	VBN	denotes	detected
T11601	16637-16639	IN	denotes	in
T11602	16640-16644	JJ	denotes	male
T11603	16656-16658	NN	denotes	NA
T11604	16645-16648	CC	denotes	and
T11605	16649-16655	JJ	denotes	female
T11606	16658-16660	,	denotes	,
T11607	16660-16672	RB	denotes	respectively
T11608	16672-16674	,	denotes	,
T11609	16674-16677	VBD	denotes	was
T11610	16678-16682	RB	denotes	also
T11611	16691-16692	.	denotes	.
T11612	16692-16873	sentence	denotes	This was expected since NA was previously found to be an excellent indicator of femur length (R2 = 0.88) in HG mice [27] and as noted above this region contains the Feml2 QTL [24].
T11613	16693-16697	DT	denotes	This
T11614	16702-16710	VBN	denotes	expected
T11615	16698-16701	VBD	denotes	was
T11616	16711-16716	IN	denotes	since
T11617	16735-16740	VBN	denotes	found
T11618	16717-16719	NN	denotes	NA
T11619	16720-16723	VBD	denotes	was
T11620	16724-16734	RB	denotes	previously
T11621	16741-16743	TO	denotes	to
T11622	16744-16746	VB	denotes	be
T11623	16747-16749	DT	denotes	an
T11624	16760-16769	NN	denotes	indicator
T11625	16750-16759	JJ	denotes	excellent
T11626	16770-16772	IN	denotes	of
T11627	16773-16778	NN	denotes	femur
T11628	16779-16785	NN	denotes	length
T11629	16786-16787	-LRB-	denotes	(
T11630	16792-16796	CD	denotes	0.88
T11631	16787-16789	NN	denotes	R2
T11632	16790-16791	SYM	denotes	=
T11633	16796-16797	-RRB-	denotes	)
T11634	16798-16800	IN	denotes	in
T11635	16801-16803	NN	denotes	HG
T11636	16804-16808	NNS	denotes	mice
T11637	16809-16810	-LRB-	denotes	[
T11638	16810-16812	CD	denotes	27
T11639	16812-16813	-RRB-	denotes	]
T11640	16814-16817	CC	denotes	and
T11641	16818-16820	IN	denotes	as
T11642	16821-16826	VBN	denotes	noted
T11643	16845-16853	VBZ	denotes	contains
T11644	16827-16832	RB	denotes	above
T11645	16833-16837	DT	denotes	this
T11646	16838-16844	NN	denotes	region
T11647	16854-16857	DT	denotes	the
T11648	16864-16867	NN	denotes	QTL
T11649	16858-16863	NN	denotes	Feml2
T11650	16868-16869	-LRB-	denotes	[
T11651	16869-16871	CD	denotes	24
T11652	16871-16872	-RRB-	denotes	]
T11653	16872-16873	.	denotes	.
T11654	16873-17040	sentence	denotes	These data confirm the effects of Carfhg2 on adiposity and Feml2 on length and indicate the isolated effects of Carfhg2 are more significant than originally observed.
T11655	16874-16879	DT	denotes	These
T11656	16880-16884	NNS	denotes	data
T11657	16885-16892	VBP	denotes	confirm
T11658	16893-16896	DT	denotes	the
T11659	16897-16904	NNS	denotes	effects
T11660	16905-16907	IN	denotes	of
T11661	16908-16915	NN	denotes	Carfhg2
T11662	16916-16918	IN	denotes	on
T11663	16919-16928	NN	denotes	adiposity
T11664	16929-16932	CC	denotes	and
T11665	16933-16938	NN	denotes	Feml2
T11666	16939-16941	IN	denotes	on
T11667	16942-16948	NN	denotes	length
T11668	16949-16952	CC	denotes	and
T11669	16953-16961	VBP	denotes	indicate
T11670	16962-16965	DT	denotes	the
T11671	16975-16982	NNS	denotes	effects
T11672	16966-16974	VBN	denotes	isolated
T11673	16994-16997	VBP	denotes	are
T11674	16983-16985	IN	denotes	of
T11675	16986-16993	NN	denotes	Carfhg2
T11676	16998-17002	RBR	denotes	more
T11677	17003-17014	JJ	denotes	significant
T11678	17015-17019	IN	denotes	than
T11679	17031-17039	VBN	denotes	observed
T11680	17020-17030	RB	denotes	originally
T11681	17039-17040	.	denotes	.
T11682	17040-17046	sentence	denotes	HG11
T11683	17042-17046	NN	denotes	HG11
T11684	17046-17194	sentence	denotes	In the original intercross CAST alleles near 50 cM on MMU11 were linked with a reduction in G29, carcass ash (ASH) and carcass protein (PROT) [24].
T11685	17047-17049	IN	denotes	In
T11686	17112-17118	VBN	denotes	linked
T11687	17050-17053	DT	denotes	the
T11688	17063-17073	NN	denotes	intercross
T11689	17054-17062	JJ	denotes	original
T11690	17074-17078	NN	denotes	CAST
T11691	17079-17086	NNS	denotes	alleles
T11692	17087-17091	IN	denotes	near
T11693	17092-17094	CD	denotes	50
T11694	17095-17097	NN	denotes	cM
T11695	17098-17100	IN	denotes	on
T11696	17101-17106	NN	denotes	MMU11
T11697	17107-17111	VBD	denotes	were
T11698	17119-17123	IN	denotes	with
T11699	17124-17125	DT	denotes	a
T11700	17126-17135	NN	denotes	reduction
T11701	17136-17138	IN	denotes	in
T11702	17139-17142	NN	denotes	G29
T11703	17142-17144	,	denotes	,
T11704	17144-17151	NN	denotes	carcass
T11705	17152-17155	NN	denotes	ash
T11706	17156-17157	-LRB-	denotes	(
T11707	17157-17160	NN	denotes	ASH
T11708	17160-17161	-RRB-	denotes	)
T11709	17162-17165	CC	denotes	and
T11710	17166-17173	NN	denotes	carcass
T11711	17174-17181	NN	denotes	protein
T11712	17182-17183	-LRB-	denotes	(
T11713	17183-17187	NN	denotes	PROT
T11714	17187-17188	-RRB-	denotes	)
T11715	17189-17190	-LRB-	denotes	[
T11716	17190-17192	CD	denotes	24
T11717	17192-17193	-RRB-	denotes	]
T11718	17193-17194	.	denotes	.
T11719	17194-17313	sentence	denotes	Therefore, we measured each carcass component using chemical compositional analysis in the HGC, HG11 and HG17 strains.
T11720	17195-17204	RB	denotes	Therefore
T11721	17209-17217	VBD	denotes	measured
T11722	17204-17206	,	denotes	,
T11723	17206-17208	PRP	denotes	we
T11724	17218-17222	DT	denotes	each
T11725	17231-17240	NN	denotes	component
T11726	17223-17230	NN	denotes	carcass
T11727	17241-17246	VBG	denotes	using
T11728	17247-17255	JJ	denotes	chemical
T11729	17270-17278	NN	denotes	analysis
T11730	17256-17269	JJ	denotes	compositional
T11731	17279-17281	IN	denotes	in
T11732	17282-17285	DT	denotes	the
T11733	17305-17312	NNS	denotes	strains
T11734	17286-17289	NN	denotes	HGC
T11735	17289-17291	,	denotes	,
T11736	17291-17295	NN	denotes	HG11
T11737	17296-17299	CC	denotes	and
T11738	17300-17304	NN	denotes	HG17
T11739	17312-17313	.	denotes	.
T11740	17313-17418	sentence	denotes	Originally, Carp2 was dependent on the presence of hg and no significant sex effects were detected [24].
T11741	17314-17324	RB	denotes	Originally
T11742	17332-17335	VBD	denotes	was
T11743	17324-17326	,	denotes	,
T11744	17326-17331	NN	denotes	Carp2
T11745	17336-17345	JJ	denotes	dependent
T11746	17346-17348	IN	denotes	on
T11747	17349-17352	DT	denotes	the
T11748	17353-17361	NN	denotes	presence
T11749	17362-17364	IN	denotes	of
T11750	17365-17367	NN	denotes	hg
T11751	17368-17371	CC	denotes	and
T11752	17372-17374	DT	denotes	no
T11753	17391-17398	NNS	denotes	effects
T11754	17375-17386	JJ	denotes	significant
T11755	17387-17390	NN	denotes	sex
T11756	17404-17412	VBN	denotes	detected
T11757	17399-17403	VBD	denotes	were
T11758	17413-17414	-LRB-	denotes	[
T11759	17414-17416	CD	denotes	24
T11760	17416-17417	-RRB-	denotes	]
T11761	17417-17418	.	denotes	.
T11762	17418-17533	sentence	denotes	In contrast to those results, HG11 mice displayed significant differences in growth and obesity between the sexes.
T11763	17419-17421	IN	denotes	In
T11764	17459-17468	VBD	denotes	displayed
T11765	17422-17430	NN	denotes	contrast
T11766	17431-17433	IN	denotes	to
T11767	17434-17439	DT	denotes	those
T11768	17440-17447	NNS	denotes	results
T11769	17447-17449	,	denotes	,
T11770	17449-17453	NN	denotes	HG11
T11771	17454-17458	NNS	denotes	mice
T11772	17469-17480	JJ	denotes	significant
T11773	17481-17492	NNS	denotes	differences
T11774	17493-17495	IN	denotes	in
T11775	17496-17502	NN	denotes	growth
T11776	17503-17506	CC	denotes	and
T11777	17507-17514	NN	denotes	obesity
T11778	17515-17522	IN	denotes	between
T11779	17523-17526	DT	denotes	the
T11780	17527-17532	NNS	denotes	sexes
T11781	17532-17533	.	denotes	.
T11782	17533-17644	sentence	denotes	In general, males demonstrated a 5% increase and females a 5% decrease in all growth-related traits (Table 4).
T11783	17534-17536	IN	denotes	In
T11784	17552-17564	VBD	denotes	demonstrated
T11785	17537-17544	JJ	denotes	general
T11786	17544-17546	,	denotes	,
T11787	17546-17551	NNS	denotes	males
T11788	17565-17566	DT	denotes	a
T11789	17570-17578	NN	denotes	increase
T11790	17567-17568	CD	denotes	5
T11791	17568-17569	NN	denotes	%
T11792	17579-17582	CC	denotes	and
T11793	17583-17590	NNS	denotes	females
T11794	17596-17604	NN	denotes	decrease
T11795	17591-17592	DT	denotes	a
T11796	17593-17594	CD	denotes	5
T11797	17594-17595	NN	denotes	%
T11798	17605-17607	IN	denotes	in
T11799	17608-17611	DT	denotes	all
T11800	17627-17633	NNS	denotes	traits
T11801	17612-17618	NN	denotes	growth
T11802	17619-17626	VBN	denotes	related
T11803	17618-17619	HYPH	denotes	-
T11804	17634-17635	-LRB-	denotes	(
T11805	17635-17640	NN	denotes	Table
T11806	17641-17642	CD	denotes	4
T11807	17642-17643	-RRB-	denotes	)
T11808	17643-17644	.	denotes	.
T11809	17644-17774	sentence	denotes	Most of these differences, however, were not significant at a critical P < 0.005, although almost all were at a nominal P < 0.05.
T11810	17645-17649	JJS	denotes	Most
T11811	17681-17685	VBD	denotes	were
T11812	17650-17652	IN	denotes	of
T11813	17653-17658	DT	denotes	these
T11814	17659-17670	NNS	denotes	differences
T11815	17670-17672	,	denotes	,
T11816	17672-17679	RB	denotes	however
T11817	17679-17681	,	denotes	,
T11818	17686-17689	RB	denotes	not
T11819	17690-17701	JJ	denotes	significant
T11820	17702-17704	IN	denotes	at
T11821	17705-17706	DT	denotes	a
T11822	17720-17725	CD	denotes	0.005
T11823	17707-17715	JJ	denotes	critical
T11824	17716-17717	NN	denotes	P
T11825	17718-17719	SYM	denotes	<
T11826	17725-17727	,	denotes	,
T11827	17727-17735	IN	denotes	although
T11828	17747-17751	VBD	denotes	were
T11829	17736-17742	RB	denotes	almost
T11830	17743-17746	DT	denotes	all
T11831	17752-17754	IN	denotes	at
T11832	17755-17756	DT	denotes	a
T11833	17769-17773	CD	denotes	0.05
T11834	17757-17764	JJ	denotes	nominal
T11835	17765-17766	NN	denotes	P
T11836	17767-17768	SYM	denotes	<
T11837	17773-17774	.	denotes	.
T11838	17774-17946	sentence	denotes	Following the same trend, males displayed an increase in tail length and a small suggestive increase in NA (P = 0.06), while females displayed significant decreases in NA.
T11839	17775-17784	VBG	denotes	Following
T11840	17807-17816	VBD	denotes	displayed
T11841	17785-17788	DT	denotes	the
T11842	17794-17799	NN	denotes	trend
T11843	17789-17793	JJ	denotes	same
T11844	17799-17801	,	denotes	,
T11845	17801-17806	NNS	denotes	males
T11846	17817-17819	DT	denotes	an
T11847	17820-17828	NN	denotes	increase
T11848	17829-17831	IN	denotes	in
T11849	17832-17836	NN	denotes	tail
T11850	17837-17843	NN	denotes	length
T11851	17844-17847	CC	denotes	and
T11852	17848-17849	DT	denotes	a
T11853	17867-17875	NN	denotes	increase
T11854	17850-17855	JJ	denotes	small
T11855	17856-17866	JJ	denotes	suggestive
T11856	17876-17878	IN	denotes	in
T11857	17879-17881	NN	denotes	NA
T11858	17882-17883	-LRB-	denotes	(
T11859	17887-17891	CD	denotes	0.06
T11860	17883-17884	NN	denotes	P
T11861	17885-17886	SYM	denotes	=
T11862	17891-17892	-RRB-	denotes	)
T11863	17892-17894	,	denotes	,
T11864	17894-17899	IN	denotes	while
T11865	17908-17917	VBD	denotes	displayed
T11866	17900-17907	NNS	denotes	females
T11867	17918-17929	JJ	denotes	significant
T11868	17930-17939	NNS	denotes	decreases
T11869	17940-17942	IN	denotes	in
T11870	17943-17945	NN	denotes	NA
T11871	17945-17946	.	denotes	.
T11872	17946-18119	sentence	denotes	In support of the sex-specific QTL effects strain by sex interactions (P < 0.04) were seen for the following growth traits: 3WK, 6WK, 9WK, G26, G29 and NA (data not shown).
T11873	17947-17949	IN	denotes	In
T11874	18033-18037	VBN	denotes	seen
T11875	17950-17957	NN	denotes	support
T11876	17958-17960	IN	denotes	of
T11877	17961-17964	DT	denotes	the
T11878	17978-17981	NN	denotes	QTL
T11879	17965-17968	NN	denotes	sex
T11880	17969-17977	JJ	denotes	specific
T11881	17968-17969	HYPH	denotes	-
T11882	17982-17989	NNS	denotes	effects
T11883	17990-17996	NN	denotes	strain
T11884	18004-18016	NNS	denotes	interactions
T11885	17997-17999	IN	denotes	by
T11886	18000-18003	NN	denotes	sex
T11887	18017-18018	-LRB-	denotes	(
T11888	18022-18026	CD	denotes	0.04
T11889	18018-18019	NN	denotes	P
T11890	18020-18021	SYM	denotes	<
T11891	18026-18027	-RRB-	denotes	)
T11892	18028-18032	VBD	denotes	were
T11893	18038-18041	IN	denotes	for
T11894	18042-18045	DT	denotes	the
T11895	18063-18069	NNS	denotes	traits
T11896	18046-18055	JJ	denotes	following
T11897	18056-18062	NN	denotes	growth
T11898	18069-18071	:	denotes	:
T11899	18071-18074	NN	denotes	3WK
T11900	18074-18076	,	denotes	,
T11901	18076-18079	NN	denotes	6WK
T11902	18079-18081	,	denotes	,
T11903	18081-18084	NN	denotes	9WK
T11904	18084-18086	,	denotes	,
T11905	18086-18089	NN	denotes	G26
T11906	18089-18091	,	denotes	,
T11907	18091-18094	NN	denotes	G29
T11908	18095-18098	CC	denotes	and
T11909	18099-18101	NN	denotes	NA
T11910	18102-18103	-LRB-	denotes	(
T11911	18112-18117	VBN	denotes	shown
T11912	18103-18107	NNS	denotes	data
T11913	18108-18111	RB	denotes	not
T11914	18117-18118	-RRB-	denotes	)
T11915	18118-18119	.	denotes	.
T11916	18119-18205	sentence	denotes	The basis of each interaction was an increase in the males and a decrease in females.
T11917	18120-18123	DT	denotes	The
T11918	18124-18129	NN	denotes	basis
T11919	18150-18153	VBD	denotes	was
T11920	18130-18132	IN	denotes	of
T11921	18133-18137	DT	denotes	each
T11922	18138-18149	NN	denotes	interaction
T11923	18154-18156	DT	denotes	an
T11924	18157-18165	NN	denotes	increase
T11925	18166-18168	IN	denotes	in
T11926	18169-18172	DT	denotes	the
T11927	18173-18178	NNS	denotes	males
T11928	18179-18182	CC	denotes	and
T11929	18183-18184	DT	denotes	a
T11930	18185-18193	NN	denotes	decrease
T11931	18194-18196	IN	denotes	in
T11932	18197-18204	NNS	denotes	females
T11933	18204-18205	.	denotes	.
T11934	18205-18368	sentence	denotes	In our analysis of the HGC, HG11 and HG17 strains, concordant results were observed measuring adiposity using chemical lipid extraction and weighing fat pad mass.
T11935	18206-18208	IN	denotes	In
T11936	18281-18289	VBN	denotes	observed
T11937	18209-18212	PRP$	denotes	our
T11938	18213-18221	NN	denotes	analysis
T11939	18222-18224	IN	denotes	of
T11940	18225-18228	DT	denotes	the
T11941	18248-18255	NNS	denotes	strains
T11942	18229-18232	NN	denotes	HGC
T11943	18232-18234	,	denotes	,
T11944	18234-18238	NN	denotes	HG11
T11945	18239-18242	CC	denotes	and
T11946	18243-18247	NN	denotes	HG17
T11947	18255-18257	,	denotes	,
T11948	18257-18267	JJ	denotes	concordant
T11949	18268-18275	NNS	denotes	results
T11950	18276-18280	VBD	denotes	were
T11951	18290-18299	VBG	denotes	measuring
T11952	18300-18309	NN	denotes	adiposity
T11953	18310-18315	VBG	denotes	using
T11954	18316-18324	JJ	denotes	chemical
T11955	18331-18341	NN	denotes	extraction
T11956	18325-18330	NN	denotes	lipid
T11957	18342-18345	CC	denotes	and
T11958	18346-18354	VBG	denotes	weighing
T11959	18355-18358	NN	denotes	fat
T11960	18359-18362	NN	denotes	pad
T11961	18363-18367	NN	denotes	mass
T11962	18367-18368	.	denotes	.
T11963	18368-18662	sentence	denotes	The phenotypic correlation between carcass fat (FAT) as a percent of the empty carcass weight (ECW; weight of total body (including organs) minus the head and gastrointestinal tract) (%FAT) determined by chemical analysis and AI, using data from all three lines (HGC, HG11 and HG17), was 0.92.
T11964	18369-18372	DT	denotes	The
T11965	18384-18395	NN	denotes	correlation
T11966	18373-18383	JJ	denotes	phenotypic
T11967	18653-18656	VBD	denotes	was
T11968	18396-18403	IN	denotes	between
T11969	18404-18411	NN	denotes	carcass
T11970	18412-18415	NN	denotes	fat
T11971	18416-18417	-LRB-	denotes	(
T11972	18417-18420	NN	denotes	FAT
T11973	18420-18421	-RRB-	denotes	)
T11974	18422-18424	IN	denotes	as
T11975	18425-18426	DT	denotes	a
T11976	18427-18434	NN	denotes	percent
T11977	18435-18437	IN	denotes	of
T11978	18438-18441	DT	denotes	the
T11979	18456-18462	NN	denotes	weight
T11980	18442-18447	JJ	denotes	empty
T11981	18448-18455	NN	denotes	carcass
T11982	18463-18464	-LRB-	denotes	(
T11983	18464-18467	NN	denotes	ECW
T11984	18467-18468	:	denotes	;
T11985	18469-18475	NN	denotes	weight
T11986	18476-18478	IN	denotes	of
T11987	18479-18484	JJ	denotes	total
T11988	18485-18489	NN	denotes	body
T11989	18490-18491	-LRB-	denotes	(
T11990	18491-18500	VBG	denotes	including
T11991	18501-18507	NNS	denotes	organs
T11992	18507-18508	-RRB-	denotes	)
T11993	18509-18514	CC	denotes	minus
T11994	18515-18518	DT	denotes	the
T11995	18519-18523	NN	denotes	head
T11996	18524-18527	CC	denotes	and
T11997	18528-18544	JJ	denotes	gastrointestinal
T11998	18545-18550	NN	denotes	tract
T11999	18550-18551	-RRB-	denotes	)
T12000	18552-18553	-LRB-	denotes	(
T12001	18553-18554	NN	denotes	%
T12002	18554-18557	NN	denotes	FAT
T12003	18557-18558	-RRB-	denotes	)
T12004	18559-18569	VBN	denotes	determined
T12005	18570-18572	IN	denotes	by
T12006	18573-18581	JJ	denotes	chemical
T12007	18582-18590	NN	denotes	analysis
T12008	18591-18594	CC	denotes	and
T12009	18595-18597	NN	denotes	AI
T12010	18597-18599	,	denotes	,
T12011	18599-18604	VBG	denotes	using
T12012	18605-18609	NNS	denotes	data
T12013	18610-18614	IN	denotes	from
T12014	18615-18618	DT	denotes	all
T12015	18625-18630	NNS	denotes	lines
T12016	18619-18624	CD	denotes	three
T12017	18631-18632	-LRB-	denotes	(
T12018	18632-18635	NN	denotes	HGC
T12019	18635-18637	,	denotes	,
T12020	18637-18641	NN	denotes	HG11
T12021	18642-18645	CC	denotes	and
T12022	18646-18650	NN	denotes	HG17
T12023	18650-18651	-RRB-	denotes	)
T12024	18651-18653	,	denotes	,
T12025	18657-18661	CD	denotes	0.92
T12026	18661-18662	.	denotes	.
T12027	18662-18872	sentence	denotes	These data suggest that individual fat pad dissection is an excellent proxy for measuring whole body adiposity and provides a much more sensitive technique to measure fat accumulation in specific body regions.
T12028	18663-18668	DT	denotes	These
T12029	18669-18673	NNS	denotes	data
T12030	18674-18681	VBP	denotes	suggest
T12031	18682-18686	IN	denotes	that
T12032	18717-18719	VBZ	denotes	is
T12033	18687-18697	JJ	denotes	individual
T12034	18706-18716	NN	denotes	dissection
T12035	18698-18701	NN	denotes	fat
T12036	18702-18705	NN	denotes	pad
T12037	18720-18722	DT	denotes	an
T12038	18733-18738	NN	denotes	proxy
T12039	18723-18732	JJ	denotes	excellent
T12040	18739-18742	IN	denotes	for
T12041	18743-18752	VBG	denotes	measuring
T12042	18753-18758	JJ	denotes	whole
T12043	18759-18763	NN	denotes	body
T12044	18764-18773	NN	denotes	adiposity
T12045	18774-18777	CC	denotes	and
T12046	18778-18786	VBZ	denotes	provides
T12047	18787-18788	DT	denotes	a
T12048	18809-18818	NN	denotes	technique
T12049	18789-18793	RB	denotes	much
T12050	18794-18798	RBR	denotes	more
T12051	18799-18808	JJ	denotes	sensitive
T12052	18819-18821	TO	denotes	to
T12053	18822-18829	VB	denotes	measure
T12054	18830-18833	NN	denotes	fat
T12055	18834-18846	NN	denotes	accumulation
T12056	18847-18849	IN	denotes	in
T12057	18850-18858	JJ	denotes	specific
T12058	18864-18871	NNS	denotes	regions
T12059	18859-18863	NN	denotes	body
T12060	18871-18872	.	denotes	.
T12061	18872-19016	sentence	denotes	HG11 females displayed slight increases in all fat pads (except MFP) and AI, although, only the 16.5% increase in AI was significant (Table 5).
T12062	18873-18877	NN	denotes	HG11
T12063	18878-18885	NNS	denotes	females
T12064	18886-18895	VBD	denotes	displayed
T12065	18896-18902	JJ	denotes	slight
T12066	18903-18912	NNS	denotes	increases
T12067	18913-18915	IN	denotes	in
T12068	18916-18919	DT	denotes	all
T12069	18924-18928	NNS	denotes	pads
T12070	18920-18923	NN	denotes	fat
T12071	18929-18930	-LRB-	denotes	(
T12072	18930-18936	IN	denotes	except
T12073	18937-18940	NN	denotes	MFP
T12074	18940-18941	-RRB-	denotes	)
T12075	18942-18945	CC	denotes	and
T12076	18946-18948	NN	denotes	AI
T12077	18948-18950	,	denotes	,
T12078	18950-18958	IN	denotes	although
T12079	18990-18993	VBD	denotes	was
T12080	18958-18960	,	denotes	,
T12081	18960-18964	RB	denotes	only
T12082	18975-18983	NN	denotes	increase
T12083	18965-18968	DT	denotes	the
T12084	18969-18973	CD	denotes	16.5
T12085	18973-18974	NN	denotes	%
T12086	18984-18986	IN	denotes	in
T12087	18987-18989	NN	denotes	AI
T12088	18994-19005	JJ	denotes	significant
T12089	19006-19007	-LRB-	denotes	(
T12090	19007-19012	NN	denotes	Table
T12091	19013-19014	CD	denotes	5
T12092	19014-19015	-RRB-	denotes	)
T12093	19015-19016	.	denotes	.
T12094	19016-19166	sentence	denotes	In contrast, HG11 males did not show a difference in fat mass leading to a significant strain by sex interaction (P = 0.008) for AI (data not shown).
T12095	19017-19019	IN	denotes	In
T12096	19049-19053	VB	denotes	show
T12097	19020-19028	NN	denotes	contrast
T12098	19028-19030	,	denotes	,
T12099	19030-19034	NN	denotes	HG11
T12100	19035-19040	NNS	denotes	males
T12101	19041-19044	VBD	denotes	did
T12102	19045-19048	RB	denotes	not
T12103	19054-19055	DT	denotes	a
T12104	19056-19066	NN	denotes	difference
T12105	19067-19069	IN	denotes	in
T12106	19070-19073	NN	denotes	fat
T12107	19074-19078	NN	denotes	mass
T12108	19079-19086	VBG	denotes	leading
T12109	19087-19089	IN	denotes	to
T12110	19090-19091	DT	denotes	a
T12111	19118-19129	NN	denotes	interaction
T12112	19092-19103	JJ	denotes	significant
T12113	19104-19110	NN	denotes	strain
T12114	19111-19113	IN	denotes	by
T12115	19114-19117	NN	denotes	sex
T12116	19130-19131	-LRB-	denotes	(
T12117	19135-19140	CD	denotes	0.008
T12118	19131-19132	NN	denotes	P
T12119	19133-19134	SYM	denotes	=
T12120	19140-19141	-RRB-	denotes	)
T12121	19142-19145	IN	denotes	for
T12122	19146-19148	NN	denotes	AI
T12123	19149-19150	-LRB-	denotes	(
T12124	19159-19164	VBN	denotes	shown
T12125	19150-19154	NNS	denotes	data
T12126	19155-19158	RB	denotes	not
T12127	19164-19165	-RRB-	denotes	)
T12128	19165-19166	.	denotes	.
T12129	19166-19286	sentence	denotes	Identical to the results obtained using fat pad weights; female HG11 carcasses displayed an increase in %FAT (Table 6).
T12130	19167-19176	JJ	denotes	Identical
T12131	19246-19255	VBD	denotes	displayed
T12132	19177-19179	IN	denotes	to
T12133	19180-19183	DT	denotes	the
T12134	19184-19191	NNS	denotes	results
T12135	19192-19200	VBN	denotes	obtained
T12136	19201-19206	VBG	denotes	using
T12137	19207-19210	NN	denotes	fat
T12138	19211-19214	NN	denotes	pad
T12139	19215-19222	NNS	denotes	weights
T12140	19222-19223	:	denotes	;
T12141	19224-19230	JJ	denotes	female
T12142	19236-19245	NNS	denotes	carcasses
T12143	19231-19235	NN	denotes	HG11
T12144	19256-19258	DT	denotes	an
T12145	19259-19267	NN	denotes	increase
T12146	19268-19270	IN	denotes	in
T12147	19271-19272	NN	denotes	%
T12148	19272-19275	NN	denotes	FAT
T12149	19276-19277	-LRB-	denotes	(
T12150	19277-19282	NN	denotes	Table
T12151	19283-19284	CD	denotes	6
T12152	19284-19285	-RRB-	denotes	)
T12153	19285-19286	.	denotes	.
T12154	19286-19439	sentence	denotes	HG11 male carcasses had higher levels carcass ash (ASH) as a percent of ECW (%ASH) and female carcasses displayed lower levels of H2O and ASH (Table 6).
T12155	19287-19291	NN	denotes	HG11
T12156	19297-19306	NNS	denotes	carcasses
T12157	19292-19296	JJ	denotes	male
T12158	19307-19310	VBD	denotes	had
T12159	19311-19317	JJR	denotes	higher
T12160	19318-19324	NNS	denotes	levels
T12161	19325-19332	NN	denotes	carcass
T12162	19333-19336	NN	denotes	ash
T12163	19337-19338	-LRB-	denotes	(
T12164	19338-19341	NN	denotes	ASH
T12165	19341-19342	-RRB-	denotes	)
T12166	19343-19345	IN	denotes	as
T12167	19346-19347	DT	denotes	a
T12168	19348-19355	NN	denotes	percent
T12169	19356-19358	IN	denotes	of
T12170	19359-19362	NN	denotes	ECW
T12171	19363-19364	-LRB-	denotes	(
T12172	19364-19365	NN	denotes	%
T12173	19365-19368	NN	denotes	ASH
T12174	19368-19369	-RRB-	denotes	)
T12175	19370-19373	CC	denotes	and
T12176	19374-19380	JJ	denotes	female
T12177	19381-19390	NNS	denotes	carcasses
T12178	19391-19400	VBD	denotes	displayed
T12179	19401-19406	JJR	denotes	lower
T12180	19407-19413	NNS	denotes	levels
T12181	19414-19416	IN	denotes	of
T12182	19417-19420	NN	denotes	H2O
T12183	19421-19424	CC	denotes	and
T12184	19425-19428	NN	denotes	ASH
T12185	19429-19430	-LRB-	denotes	(
T12186	19430-19435	NN	denotes	Table
T12187	19436-19437	CD	denotes	6
T12188	19437-19438	-RRB-	denotes	)
T12189	19438-19439	.	denotes	.
T12190	19439-19547	sentence	denotes	Strains by sex interactions (P < 0.005) were identified for H2O, %H2O, %FAT, ASH and PROT (data not shown).
T12191	19440-19447	NNS	denotes	Strains
T12192	19455-19467	NNS	denotes	interactions
T12193	19448-19450	IN	denotes	by
T12194	19451-19454	NN	denotes	sex
T12195	19485-19495	VBN	denotes	identified
T12196	19468-19469	-LRB-	denotes	(
T12197	19473-19478	CD	denotes	0.005
T12198	19469-19470	NN	denotes	P
T12199	19471-19472	SYM	denotes	<
T12200	19478-19479	-RRB-	denotes	)
T12201	19480-19484	VBD	denotes	were
T12202	19496-19499	IN	denotes	for
T12203	19500-19503	NN	denotes	H2O
T12204	19503-19505	,	denotes	,
T12205	19505-19506	NN	denotes	%
T12206	19506-19509	NN	denotes	H2O
T12207	19509-19511	,	denotes	,
T12208	19511-19512	NN	denotes	%
T12209	19512-19515	NN	denotes	FAT
T12210	19515-19517	,	denotes	,
T12211	19517-19520	NN	denotes	ASH
T12212	19521-19524	CC	denotes	and
T12213	19525-19529	NN	denotes	PROT
T12214	19530-19531	-LRB-	denotes	(
T12215	19540-19545	VBN	denotes	shown
T12216	19531-19535	NNS	denotes	data
T12217	19536-19539	RB	denotes	not
T12218	19545-19546	-RRB-	denotes	)
T12219	19546-19547	.	denotes	.
T12220	19547-19792	sentence	denotes	If the aggregate phenotype in HG11 is due to a single locus, its function may be to disrupt energy partitioning by decreasing the deposition of lean tissue and increasing lipid accumulation in females, while having the opposite action in males.
T12221	19548-19550	IN	denotes	If
T12222	19583-19585	VBZ	denotes	is
T12223	19551-19554	DT	denotes	the
T12224	19565-19574	NN	denotes	phenotype
T12225	19555-19564	JJ	denotes	aggregate
T12226	19575-19577	IN	denotes	in
T12227	19578-19582	NN	denotes	HG11
T12228	19626-19628	VB	denotes	be
T12229	19586-19589	IN	denotes	due
T12230	19590-19592	IN	denotes	to
T12231	19593-19594	DT	denotes	a
T12232	19602-19607	NN	denotes	locus
T12233	19595-19601	JJ	denotes	single
T12234	19607-19609	,	denotes	,
T12235	19609-19612	PRP$	denotes	its
T12236	19613-19621	NN	denotes	function
T12237	19622-19625	MD	denotes	may
T12238	19629-19631	TO	denotes	to
T12239	19632-19639	VB	denotes	disrupt
T12240	19640-19646	NN	denotes	energy
T12241	19647-19659	NN	denotes	partitioning
T12242	19660-19662	IN	denotes	by
T12243	19663-19673	VBG	denotes	decreasing
T12244	19674-19677	DT	denotes	the
T12245	19678-19688	NN	denotes	deposition
T12246	19689-19691	IN	denotes	of
T12247	19692-19696	JJ	denotes	lean
T12248	19697-19703	NN	denotes	tissue
T12249	19704-19707	CC	denotes	and
T12250	19708-19718	VBG	denotes	increasing
T12251	19719-19724	NN	denotes	lipid
T12252	19725-19737	NN	denotes	accumulation
T12253	19738-19740	IN	denotes	in
T12254	19741-19748	NNS	denotes	females
T12255	19748-19750	,	denotes	,
T12256	19750-19755	IN	denotes	while
T12257	19756-19762	VBG	denotes	having
T12258	19763-19766	DT	denotes	the
T12259	19776-19782	NN	denotes	action
T12260	19767-19775	JJ	denotes	opposite
T12261	19783-19785	IN	denotes	in
T12262	19786-19791	NNS	denotes	males
T12263	19791-19792	.	denotes	.
T12264	19792-19871	sentence	denotes	However, it may also be due to distinct sex-specific QTL with opposing action.
T12265	19793-19800	RB	denotes	However
T12266	19814-19816	VB	denotes	be
T12267	19800-19802	,	denotes	,
T12268	19802-19804	PRP	denotes	it
T12269	19805-19808	MD	denotes	may
T12270	19809-19813	RB	denotes	also
T12271	19817-19820	IN	denotes	due
T12272	19821-19823	IN	denotes	to
T12273	19824-19832	JJ	denotes	distinct
T12274	19846-19849	NN	denotes	QTL
T12275	19833-19836	NN	denotes	sex
T12276	19837-19845	JJ	denotes	specific
T12277	19836-19837	HYPH	denotes	-
T12278	19850-19854	IN	denotes	with
T12279	19855-19863	VBG	denotes	opposing
T12280	19864-19870	NN	denotes	action
T12281	19870-19871	.	denotes	.
T12282	19871-19877	sentence	denotes	HG17
T12283	19873-19877	NN	denotes	HG17
T12284	19877-20044	sentence	denotes	In the original intercross CAST alleles at MMU17 markers were associated with decreases in femur length, ASH and PROT [24] and similar results were seen in HG17 mice.
T12285	19878-19880	IN	denotes	In
T12286	19940-19950	VBN	denotes	associated
T12287	19881-19884	DT	denotes	the
T12288	19894-19904	NN	denotes	intercross
T12289	19885-19893	JJ	denotes	original
T12290	19905-19909	NN	denotes	CAST
T12291	19910-19917	NNS	denotes	alleles
T12292	19918-19920	IN	denotes	at
T12293	19921-19926	NN	denotes	MMU17
T12294	19927-19934	NNS	denotes	markers
T12295	19935-19939	VBD	denotes	were
T12296	19951-19955	IN	denotes	with
T12297	19956-19965	NNS	denotes	decreases
T12298	19966-19968	IN	denotes	in
T12299	19969-19974	NN	denotes	femur
T12300	19975-19981	NN	denotes	length
T12301	19981-19983	,	denotes	,
T12302	19983-19986	NN	denotes	ASH
T12303	19987-19990	CC	denotes	and
T12304	19991-19995	NN	denotes	PROT
T12305	19996-19997	-LRB-	denotes	[
T12306	19997-19999	CD	denotes	24
T12307	19999-20000	-RRB-	denotes	]
T12308	20001-20004	CC	denotes	and
T12309	20005-20012	JJ	denotes	similar
T12310	20013-20020	NNS	denotes	results
T12311	20026-20030	VBN	denotes	seen
T12312	20021-20025	VBD	denotes	were
T12313	20031-20033	IN	denotes	in
T12314	20034-20038	NN	denotes	HG17
T12315	20039-20043	NNS	denotes	mice
T12316	20043-20044	.	denotes	.
T12317	20044-20206	sentence	denotes	Interestingly, both sexes were heavier at 2WK (males, P = 0.0045; females, P = 0.0342), but lighter at 9WK, leading to substantially lower G26 and G29 (Table 4).
T12318	20045-20058	RB	denotes	Interestingly
T12319	20071-20075	VBD	denotes	were
T12320	20058-20060	,	denotes	,
T12321	20060-20064	DT	denotes	both
T12322	20065-20070	NNS	denotes	sexes
T12323	20076-20083	JJR	denotes	heavier
T12324	20084-20086	IN	denotes	at
T12325	20087-20090	NN	denotes	2WK
T12326	20091-20092	-LRB-	denotes	(
T12327	20124-20130	CD	denotes	0.0342
T12328	20092-20097	NNS	denotes	males
T12329	20103-20109	CD	denotes	0.0045
T12330	20097-20099	,	denotes	,
T12331	20099-20100	NN	denotes	P
T12332	20101-20102	SYM	denotes	=
T12333	20109-20110	:	denotes	;
T12334	20111-20118	NNS	denotes	females
T12335	20118-20120	,	denotes	,
T12336	20120-20121	NN	denotes	P
T12337	20122-20123	SYM	denotes	=
T12338	20130-20131	-RRB-	denotes	)
T12339	20131-20133	,	denotes	,
T12340	20133-20136	CC	denotes	but
T12341	20137-20144	JJR	denotes	lighter
T12342	20145-20147	IN	denotes	at
T12343	20148-20151	NN	denotes	9WK
T12344	20151-20153	,	denotes	,
T12345	20153-20160	VBG	denotes	leading
T12346	20161-20163	IN	denotes	to
T12347	20164-20177	RB	denotes	substantially
T12348	20178-20183	JJR	denotes	lower
T12349	20184-20187	NN	denotes	G26
T12350	20188-20191	CC	denotes	and
T12351	20192-20195	NN	denotes	G29
T12352	20196-20197	-LRB-	denotes	(
T12353	20197-20202	NN	denotes	Table
T12354	20203-20204	CD	denotes	4
T12355	20204-20205	-RRB-	denotes	)
T12356	20205-20206	.	denotes	.
T12357	20206-20286	sentence	denotes	In general growth differences ranged between 5% and 15% lower in congenic mice.
T12358	20207-20209	IN	denotes	In
T12359	20237-20243	VBD	denotes	ranged
T12360	20210-20217	JJ	denotes	general
T12361	20218-20224	NN	denotes	growth
T12362	20225-20236	NNS	denotes	differences
T12363	20244-20251	IN	denotes	between
T12364	20252-20253	CD	denotes	5
T12365	20253-20254	NN	denotes	%
T12366	20255-20258	CC	denotes	and
T12367	20259-20261	CD	denotes	15
T12368	20261-20262	NN	denotes	%
T12369	20263-20268	JJR	denotes	lower
T12370	20269-20271	IN	denotes	in
T12371	20272-20280	JJ	denotes	congenic
T12372	20281-20285	NNS	denotes	mice
T12373	20285-20286	.	denotes	.
T12374	20286-20367	sentence	denotes	Both sexes had significant reductions in length traits relative to control mice.
T12375	20287-20291	DT	denotes	Both
T12376	20292-20297	NNS	denotes	sexes
T12377	20298-20301	VBD	denotes	had
T12378	20302-20313	JJ	denotes	significant
T12379	20314-20324	NNS	denotes	reductions
T12380	20325-20327	IN	denotes	in
T12381	20328-20334	NN	denotes	length
T12382	20335-20341	NNS	denotes	traits
T12383	20342-20350	JJ	denotes	relative
T12384	20351-20353	IN	denotes	to
T12385	20354-20361	NN	denotes	control
T12386	20362-20366	NNS	denotes	mice
T12387	20366-20367	.	denotes	.
T12388	20367-20458	sentence	denotes	NA was reduced by 2.7% (P = 0.0186) and 3.4% in males and females, respectively (Table 4).
T12389	20368-20370	NN	denotes	NA
T12390	20375-20382	VBN	denotes	reduced
T12391	20371-20374	VBD	denotes	was
T12392	20383-20385	IN	denotes	by
T12393	20386-20389	CD	denotes	2.7
T12394	20389-20390	NN	denotes	%
T12395	20391-20392	-LRB-	denotes	(
T12396	20396-20402	CD	denotes	0.0186
T12397	20392-20393	NN	denotes	P
T12398	20394-20395	SYM	denotes	=
T12399	20402-20403	-RRB-	denotes	)
T12400	20404-20407	CC	denotes	and
T12401	20408-20411	CD	denotes	3.4
T12402	20411-20412	NN	denotes	%
T12403	20413-20415	IN	denotes	in
T12404	20416-20421	NNS	denotes	males
T12405	20422-20425	CC	denotes	and
T12406	20426-20433	NNS	denotes	females
T12407	20433-20435	,	denotes	,
T12408	20435-20447	RB	denotes	respectively
T12409	20448-20449	-LRB-	denotes	(
T12410	20449-20454	NN	denotes	Table
T12411	20455-20456	CD	denotes	4
T12412	20456-20457	-RRB-	denotes	)
T12413	20457-20458	.	denotes	.
T12414	20458-20533	sentence	denotes	In addition, tail was reduced by approximately 6% in both sexes (Table 4).
T12415	20459-20461	IN	denotes	In
T12416	20481-20488	VBN	denotes	reduced
T12417	20462-20470	NN	denotes	addition
T12418	20470-20472	,	denotes	,
T12419	20472-20476	NN	denotes	tail
T12420	20477-20480	VBD	denotes	was
T12421	20489-20491	IN	denotes	by
T12422	20492-20505	RB	denotes	approximately
T12423	20506-20507	CD	denotes	6
T12424	20507-20508	NN	denotes	%
T12425	20509-20511	IN	denotes	in
T12426	20512-20516	DT	denotes	both
T12427	20517-20522	NNS	denotes	sexes
T12428	20523-20524	-LRB-	denotes	(
T12429	20524-20529	NN	denotes	Table
T12430	20530-20531	CD	denotes	4
T12431	20531-20532	-RRB-	denotes	)
T12432	20532-20533	.	denotes	.
T12433	20533-20626	sentence	denotes	In general, HG17 mice displayed increases in all fat pads (except MFP), TF and AI (Table 5).
T12434	20534-20536	IN	denotes	In
T12435	20556-20565	VBD	denotes	displayed
T12436	20537-20544	JJ	denotes	general
T12437	20544-20546	,	denotes	,
T12438	20546-20550	NN	denotes	HG17
T12439	20551-20555	NNS	denotes	mice
T12440	20566-20575	NNS	denotes	increases
T12441	20576-20578	IN	denotes	in
T12442	20579-20582	DT	denotes	all
T12443	20587-20591	NNS	denotes	pads
T12444	20583-20586	NN	denotes	fat
T12445	20592-20593	-LRB-	denotes	(
T12446	20593-20599	IN	denotes	except
T12447	20600-20603	NN	denotes	MFP
T12448	20603-20604	-RRB-	denotes	)
T12449	20604-20606	,	denotes	,
T12450	20606-20608	NN	denotes	TF
T12451	20609-20612	CC	denotes	and
T12452	20613-20615	NN	denotes	AI
T12453	20616-20617	-LRB-	denotes	(
T12454	20617-20622	NN	denotes	Table
T12455	20623-20624	CD	denotes	5
T12456	20624-20625	-RRB-	denotes	)
T12457	20625-20626	.	denotes	.
T12458	20626-20701	sentence	denotes	However, none of these differences were significant at critical P < 0.005.
T12459	20627-20634	RB	denotes	However
T12460	20662-20666	VBD	denotes	were
T12461	20634-20636	,	denotes	,
T12462	20636-20640	NN	denotes	none
T12463	20641-20643	IN	denotes	of
T12464	20644-20649	DT	denotes	these
T12465	20650-20661	NNS	denotes	differences
T12466	20667-20678	JJ	denotes	significant
T12467	20679-20681	IN	denotes	at
T12468	20682-20690	JJ	denotes	critical
T12469	20695-20700	CD	denotes	0.005
T12470	20691-20692	NN	denotes	P
T12471	20693-20694	SYM	denotes	<
T12472	20700-20701	.	denotes	.
T12473	20701-20860	sentence	denotes	In addition, HG17 male carcasses possessed lower levels of H2O and ASH, while female carcasses contained lower levels of % H2O, ASH, %ASH and %PROT (Table 6).
T12474	20702-20704	IN	denotes	In
T12475	20735-20744	VBD	denotes	possessed
T12476	20705-20713	NN	denotes	addition
T12477	20713-20715	,	denotes	,
T12478	20715-20719	NN	denotes	HG17
T12479	20725-20734	NNS	denotes	carcasses
T12480	20720-20724	JJ	denotes	male
T12481	20745-20750	JJR	denotes	lower
T12482	20751-20757	NNS	denotes	levels
T12483	20758-20760	IN	denotes	of
T12484	20761-20764	NN	denotes	H2O
T12485	20765-20768	CC	denotes	and
T12486	20769-20772	NN	denotes	ASH
T12487	20772-20774	,	denotes	,
T12488	20774-20779	IN	denotes	while
T12489	20797-20806	VBD	denotes	contained
T12490	20780-20786	JJ	denotes	female
T12491	20787-20796	NNS	denotes	carcasses
T12492	20807-20812	JJR	denotes	lower
T12493	20813-20819	NNS	denotes	levels
T12494	20820-20822	IN	denotes	of
T12495	20823-20824	NN	denotes	%
T12496	20825-20828	NN	denotes	H2O
T12497	20828-20830	,	denotes	,
T12498	20830-20833	NN	denotes	ASH
T12499	20833-20835	,	denotes	,
T12500	20835-20836	NN	denotes	%
T12501	20836-20839	NN	denotes	ASH
T12502	20840-20843	CC	denotes	and
T12503	20844-20845	NN	denotes	%
T12504	20845-20849	NN	denotes	PROT
T12505	20850-20851	-LRB-	denotes	(
T12506	20851-20856	NN	denotes	Table
T12507	20857-20858	CD	denotes	6
T12508	20858-20859	-RRB-	denotes	)
T12509	20859-20860	.	denotes	.
T13271	20862-20865	NN	denotes	MMU
T13272	20865-20866	CD	denotes	2
T13273	20908-20918	NN	denotes	sequencing
T13274	20866-20868	,	denotes	,
T13275	20868-20869	CD	denotes	9
T13276	20869-20871	,	denotes	,
T13277	20871-20873	CD	denotes	11
T13278	20874-20877	CC	denotes	and
T13279	20878-20880	CD	denotes	17
T13280	20881-20883	NN	denotes	hg
T13281	20884-20892	NN	denotes	modifier
T13282	20893-20902	NN	denotes	candidate
T13283	20903-20907	NN	denotes	gene
T13284	20918-21132	sentence	denotes	The HG phenotype is due to the deletion of Socs2, therefore we reasoned that QTL on MMU2, 9, 11 and 17 interacting with hg possibly represent variation within genes participating in various aspects of Gh function.
T13285	20919-20922	DT	denotes	The
T13286	20926-20935	NN	denotes	phenotype
T13287	20923-20925	NN	denotes	HG
T13288	20936-20938	VBZ	denotes	is
T13289	20982-20990	VBD	denotes	reasoned
T13290	20939-20942	IN	denotes	due
T13291	20943-20945	IN	denotes	to
T13292	20946-20949	DT	denotes	the
T13293	20950-20958	NN	denotes	deletion
T13294	20959-20961	IN	denotes	of
T13295	20962-20967	NN	denotes	Socs2
T13296	20967-20969	,	denotes	,
T13297	20969-20978	RB	denotes	therefore
T13298	20979-20981	PRP	denotes	we
T13299	20991-20995	IN	denotes	that
T13300	21051-21060	VBP	denotes	represent
T13301	20996-20999	NN	denotes	QTL
T13302	21000-21002	IN	denotes	on
T13303	21003-21006	NN	denotes	MMU
T13304	21006-21007	CD	denotes	2
T13305	21007-21009	,	denotes	,
T13306	21009-21010	CD	denotes	9
T13307	21010-21012	,	denotes	,
T13308	21012-21014	CD	denotes	11
T13309	21015-21018	CC	denotes	and
T13310	21019-21021	CD	denotes	17
T13311	21022-21033	VBG	denotes	interacting
T13312	21034-21038	IN	denotes	with
T13313	21039-21041	NN	denotes	hg
T13314	21042-21050	RB	denotes	possibly
T13315	21061-21070	NN	denotes	variation
T13316	21071-21077	IN	denotes	within
T13317	21078-21083	NNS	denotes	genes
T13318	21084-21097	VBG	denotes	participating
T13319	21098-21100	IN	denotes	in
T13320	21101-21108	JJ	denotes	various
T13321	21109-21116	NNS	denotes	aspects
T13322	21117-21119	IN	denotes	of
T13323	21120-21122	NN	denotes	Gh
T13324	21123-21131	NN	denotes	function
T13325	21131-21132	.	denotes	.
T13326	21132-21310	sentence	denotes	To select candidate genes for sequencing we identified genes known to be or potentially involved in Gh signaling, are responsive to Gh or that propagate downstream Gh functions.
T13327	21133-21135	TO	denotes	To
T13328	21136-21142	VB	denotes	select
T13329	21177-21187	VBD	denotes	identified
T13330	21143-21152	NN	denotes	candidate
T13331	21153-21158	NNS	denotes	genes
T13332	21159-21162	IN	denotes	for
T13333	21163-21173	NN	denotes	sequencing
T13334	21174-21176	PRP	denotes	we
T13335	21188-21193	NNS	denotes	genes
T13336	21194-21199	VBN	denotes	known
T13337	21200-21202	TO	denotes	to
T13338	21203-21205	VB	denotes	be
T13339	21206-21208	CC	denotes	or
T13340	21209-21220	RB	denotes	potentially
T13341	21221-21229	VBN	denotes	involved
T13342	21230-21232	IN	denotes	in
T13343	21233-21235	NN	denotes	Gh
T13344	21236-21245	NN	denotes	signaling
T13345	21245-21247	,	denotes	,
T13346	21247-21250	VBP	denotes	are
T13347	21251-21261	JJ	denotes	responsive
T13348	21262-21264	IN	denotes	to
T13349	21265-21267	NN	denotes	Gh
T13350	21268-21270	CC	denotes	or
T13351	21271-21275	WDT	denotes	that
T13352	21276-21285	VBP	denotes	propagate
T13353	21286-21296	JJ	denotes	downstream
T13354	21300-21309	NNS	denotes	functions
T13355	21297-21299	NN	denotes	Gh
T13356	21309-21310	.	denotes	.
T13357	21310-21523	sentence	denotes	Forty-four hg modifier candidate genes were identified from primary literature, reviews and book chapters and coordinated using the GenMAPP (Gene MicroArray Pathway Profiler) pathway building software (Figure 5).
T13358	21311-21316	CD	denotes	Forty
T13359	21317-21321	CD	denotes	four
T13360	21316-21317	HYPH	denotes	-
T13361	21344-21349	NNS	denotes	genes
T13362	21322-21324	NN	denotes	hg
T13363	21325-21333	NN	denotes	modifier
T13364	21334-21343	NN	denotes	candidate
T13365	21355-21365	VBN	denotes	identified
T13366	21350-21354	VBD	denotes	were
T13367	21366-21370	IN	denotes	from
T13368	21371-21378	JJ	denotes	primary
T13369	21379-21389	NN	denotes	literature
T13370	21389-21391	,	denotes	,
T13371	21391-21398	NNS	denotes	reviews
T13372	21399-21402	CC	denotes	and
T13373	21403-21407	NN	denotes	book
T13374	21408-21416	NNS	denotes	chapters
T13375	21417-21420	CC	denotes	and
T13376	21421-21432	VBN	denotes	coordinated
T13377	21433-21438	VBG	denotes	using
T13378	21439-21442	DT	denotes	the
T13379	21503-21511	NN	denotes	software
T13380	21443-21450	NNP	denotes	GenMAPP
T13381	21451-21452	-LRB-	denotes	(
T13382	21452-21456	NNP	denotes	Gene
T13383	21457-21467	NNP	denotes	MicroArray
T13384	21476-21484	NNP	denotes	Profiler
T13385	21468-21475	NNP	denotes	Pathway
T13386	21484-21485	-RRB-	denotes	)
T13387	21486-21493	NN	denotes	pathway
T13388	21494-21502	NN	denotes	building
T13389	21512-21513	-LRB-	denotes	(
T13390	21513-21519	NN	denotes	Figure
T13391	21520-21521	CD	denotes	5
T13392	21521-21522	-RRB-	denotes	)
T13393	21522-21523	.	denotes	.
T13394	21523-21687	sentence	denotes	The coding region of each gene was sequenced from the CAST strain and compared to the publicly available B6 sequence to identify polymorphisms (Additional File 4).
T13395	21524-21527	DT	denotes	The
T13396	21535-21541	NN	denotes	region
T13397	21528-21534	NN	denotes	coding
T13398	21559-21568	VBN	denotes	sequenced
T13399	21542-21544	IN	denotes	of
T13400	21545-21549	DT	denotes	each
T13401	21550-21554	NN	denotes	gene
T13402	21555-21558	VBD	denotes	was
T13403	21569-21573	IN	denotes	from
T13404	21574-21577	DT	denotes	the
T13405	21583-21589	NN	denotes	strain
T13406	21578-21582	NN	denotes	CAST
T13407	21590-21593	CC	denotes	and
T13408	21594-21602	VBN	denotes	compared
T13409	21603-21605	IN	denotes	to
T13410	21606-21609	DT	denotes	the
T13411	21632-21640	NN	denotes	sequence
T13412	21610-21618	RB	denotes	publicly
T13413	21619-21628	JJ	denotes	available
T13414	21629-21631	NN	denotes	B6
T13415	21641-21643	TO	denotes	to
T13416	21644-21652	VB	denotes	identify
T13417	21653-21666	NNS	denotes	polymorphisms
T13418	21667-21668	-LRB-	denotes	(
T13419	21679-21683	NN	denotes	File
T13420	21668-21678	JJ	denotes	Additional
T13421	21684-21685	CD	denotes	4
T13422	21685-21686	-RRB-	denotes	)
T13423	21686-21687	.	denotes	.
T13424	21687-21825	sentence	denotes	A total of 94.492 kbp was sequenced (75.378 kbp CDS and 19.114 Kbp 5' and 3' untranslated region (UTR)), representing 25,083 amino acids.
T13425	21688-21689	DT	denotes	A
T13426	21690-21695	NN	denotes	total
T13427	21714-21723	VBN	denotes	sequenced
T13428	21696-21698	IN	denotes	of
T13429	21699-21705	CD	denotes	94.492
T13430	21706-21709	NN	denotes	kbp
T13431	21710-21713	VBD	denotes	was
T13432	21724-21725	-LRB-	denotes	(
T13433	21736-21739	NN	denotes	CDS
T13434	21725-21731	CD	denotes	75.378
T13435	21732-21735	NN	denotes	kbp
T13436	21740-21743	CC	denotes	and
T13437	21744-21750	CD	denotes	19.114
T13438	21751-21754	NN	denotes	Kbp
T13439	21778-21784	NN	denotes	region
T13440	21755-21756	CD	denotes	5
T13441	21756-21757	SYM	denotes	'
T13442	21758-21761	CC	denotes	and
T13443	21762-21763	CD	denotes	3
T13444	21763-21764	SYM	denotes	'
T13445	21765-21777	JJ	denotes	untranslated
T13446	21785-21786	-LRB-	denotes	(
T13447	21786-21789	NN	denotes	UTR
T13448	21789-21790	-RRB-	denotes	)
T13449	21790-21791	-RRB-	denotes	)
T13450	21791-21793	,	denotes	,
T13451	21793-21805	VBG	denotes	representing
T13452	21806-21812	CD	denotes	25,083
T13453	21819-21824	NNS	denotes	acids
T13454	21813-21818	NN	denotes	amino
T13455	21824-21825	.	denotes	.
T13456	21825-22057	sentence	denotes	Comparison with the public B6 assembly (May 2004 University of California, Santa Cruz (UCSC [28]) mm5 genome assembly, National Center for Biotechnology Information (NCBI) Build 33) identified 307 polymorphisms between CAST and B6.
T13457	21826-21836	NN	denotes	Comparison
T13458	22008-22018	VBN	denotes	identified
T13459	21837-21841	IN	denotes	with
T13460	21842-21845	DT	denotes	the
T13461	21856-21864	NN	denotes	assembly
T13462	21846-21852	JJ	denotes	public
T13463	21853-21855	NN	denotes	B6
T13464	21865-21866	-LRB-	denotes	(
T13465	21998-22003	NN	denotes	Build
T13466	21866-21869	NNP	denotes	May
T13467	21875-21885	NNP	denotes	University
T13468	21870-21874	CD	denotes	2004
T13469	21886-21888	IN	denotes	of
T13470	21889-21899	NNP	denotes	California
T13471	21899-21901	,	denotes	,
T13472	21901-21906	NNP	denotes	Santa
T13473	21907-21911	NNP	denotes	Cruz
T13474	21912-21913	-LRB-	denotes	(
T13475	21919-21921	CD	denotes	28
T13476	21913-21917	NNP	denotes	UCSC
T13477	21918-21919	-LRB-	denotes	[
T13478	21921-21922	-RRB-	denotes	]
T13479	21922-21923	-RRB-	denotes	)
T13480	21924-21927	NN	denotes	mm5
T13481	21935-21943	NN	denotes	assembly
T13482	21928-21934	NN	denotes	genome
T13483	21943-21945	,	denotes	,
T13484	21945-21953	NNP	denotes	National
T13485	21954-21960	NNP	denotes	Center
T13486	21961-21964	IN	denotes	for
T13487	21965-21978	NNP	denotes	Biotechnology
T13488	21979-21990	NNP	denotes	Information
T13489	21991-21992	-LRB-	denotes	(
T13490	21992-21996	NNP	denotes	NCBI
T13491	21996-21997	-RRB-	denotes	)
T13492	22004-22006	CD	denotes	33
T13493	22006-22007	-RRB-	denotes	)
T13494	22019-22022	CD	denotes	307
T13495	22023-22036	NNS	denotes	polymorphisms
T13496	22037-22044	IN	denotes	between
T13497	22045-22049	NN	denotes	CAST
T13498	22050-22053	CC	denotes	and
T13499	22054-22056	NN	denotes	B6
T13500	22056-22057	.	denotes	.
T13501	22057-22179	sentence	denotes	Of these, 295 were single nucleotide polymorphisms (SNP) and 12 were insertions or deletions in CAST (Additional File 4).
T13502	22058-22060	IN	denotes	Of
T13503	22072-22076	VBD	denotes	were
T13504	22061-22066	DT	denotes	these
T13505	22066-22068	,	denotes	,
T13506	22068-22071	CD	denotes	295
T13507	22077-22083	JJ	denotes	single
T13508	22095-22108	NNS	denotes	polymorphisms
T13509	22084-22094	NN	denotes	nucleotide
T13510	22109-22110	-LRB-	denotes	(
T13511	22110-22113	NN	denotes	SNP
T13512	22113-22114	-RRB-	denotes	)
T13513	22115-22118	CC	denotes	and
T13514	22119-22121	CD	denotes	12
T13515	22122-22126	VBD	denotes	were
T13516	22127-22137	NNS	denotes	insertions
T13517	22138-22140	CC	denotes	or
T13518	22141-22150	NNS	denotes	deletions
T13519	22151-22153	IN	denotes	in
T13520	22154-22158	NN	denotes	CAST
T13521	22159-22160	-LRB-	denotes	(
T13522	22171-22175	NN	denotes	File
T13523	22160-22170	JJ	denotes	Additional
T13524	22176-22177	CD	denotes	4
T13525	22177-22178	-RRB-	denotes	)
T13526	22178-22179	.	denotes	.
T13527	22179-22246	sentence	denotes	All 12 insertions or deletions were located within 5' and 3' UTRs.
T13528	22180-22183	PDT	denotes	All
T13529	22187-22197	NNS	denotes	insertions
T13530	22184-22186	CD	denotes	12
T13531	22216-22223	VBN	denotes	located
T13532	22198-22200	CC	denotes	or
T13533	22201-22210	NNS	denotes	deletions
T13534	22211-22215	VBD	denotes	were
T13535	22224-22230	IN	denotes	within
T13536	22231-22232	CD	denotes	5
T13537	22241-22245	NNS	denotes	UTRs
T13538	22232-22233	SYM	denotes	'
T13539	22234-22237	CC	denotes	and
T13540	22238-22239	CD	denotes	3
T13541	22239-22240	SYM	denotes	'
T13542	22245-22246	.	denotes	.
T13543	22246-22341	sentence	denotes	Fifty-six nonsynonomous SNP (nsSNP) were identified in 14 different genes (Additional File 4).
T13544	22247-22252	CD	denotes	Fifty
T13545	22253-22256	CD	denotes	six
T13546	22252-22253	HYPH	denotes	-
T13547	22271-22274	NN	denotes	SNP
T13548	22257-22270	JJ	denotes	nonsynonomous
T13549	22288-22298	VBN	denotes	identified
T13550	22275-22276	-LRB-	denotes	(
T13551	22276-22281	NN	denotes	nsSNP
T13552	22281-22282	-RRB-	denotes	)
T13553	22283-22287	VBD	denotes	were
T13554	22299-22301	IN	denotes	in
T13555	22302-22304	CD	denotes	14
T13556	22315-22320	NNS	denotes	genes
T13557	22305-22314	JJ	denotes	different
T13558	22321-22322	-LRB-	denotes	(
T13559	22333-22337	NN	denotes	File
T13560	22322-22332	JJ	denotes	Additional
T13561	22338-22339	CD	denotes	4
T13562	22339-22340	-RRB-	denotes	)
T13563	22340-22341	.	denotes	.
T13564	22341-22613	sentence	denotes	PolyPhen [29] and SIFT [30] are software programs designed to identify nsSNP which potentially alter protein function by evaluating evolutionary conservation at specific amino acid residues using a multiple sequence alignment of protein sequences homologous to the query.
T13565	22342-22350	NNP	denotes	PolyPhen
T13566	22370-22373	VBP	denotes	are
T13567	22351-22352	-LRB-	denotes	[
T13568	22352-22354	CD	denotes	29
T13569	22354-22355	-RRB-	denotes	]
T13570	22356-22359	CC	denotes	and
T13571	22360-22364	NN	denotes	SIFT
T13572	22365-22366	-LRB-	denotes	[
T13573	22366-22368	CD	denotes	30
T13574	22368-22369	-RRB-	denotes	]
T13575	22374-22382	NN	denotes	software
T13576	22383-22391	NNS	denotes	programs
T13577	22392-22400	VBN	denotes	designed
T13578	22401-22403	TO	denotes	to
T13579	22404-22412	VB	denotes	identify
T13580	22413-22418	NN	denotes	nsSNP
T13581	22419-22424	WDT	denotes	which
T13582	22437-22442	VBP	denotes	alter
T13583	22425-22436	RB	denotes	potentially
T13584	22443-22450	NN	denotes	protein
T13585	22451-22459	NN	denotes	function
T13586	22460-22462	IN	denotes	by
T13587	22463-22473	VBG	denotes	evaluating
T13588	22474-22486	JJ	denotes	evolutionary
T13589	22487-22499	NN	denotes	conservation
T13590	22500-22502	IN	denotes	at
T13591	22503-22511	JJ	denotes	specific
T13592	22523-22531	NNS	denotes	residues
T13593	22512-22517	NN	denotes	amino
T13594	22518-22522	NN	denotes	acid
T13595	22532-22537	VBG	denotes	using
T13596	22538-22539	DT	denotes	a
T13597	22558-22567	NN	denotes	alignment
T13598	22540-22548	JJ	denotes	multiple
T13599	22549-22557	NN	denotes	sequence
T13600	22568-22570	IN	denotes	of
T13601	22571-22578	NN	denotes	protein
T13602	22579-22588	NNS	denotes	sequences
T13603	22589-22599	JJ	denotes	homologous
T13604	22600-22602	IN	denotes	to
T13605	22603-22606	DT	denotes	the
T13606	22607-22612	NN	denotes	query
T13607	22612-22613	.	denotes	.
T13608	22613-22778	sentence	denotes	When applied to our data set PolyPhen, SIFT or both programs predicted that 15 of the 56 nsSNP in 9 different genes would possibly alter protein function (Table 7).
T13609	22614-22618	WRB	denotes	When
T13610	22619-22626	VBN	denotes	applied
T13611	22675-22684	VBD	denotes	predicted
T13612	22627-22629	IN	denotes	to
T13613	22630-22633	PRP$	denotes	our
T13614	22639-22642	NN	denotes	set
T13615	22634-22638	NNS	denotes	data
T13616	22643-22651	NNP	denotes	PolyPhen
T13617	22651-22653	,	denotes	,
T13618	22653-22657	NNP	denotes	SIFT
T13619	22658-22660	CC	denotes	or
T13620	22661-22665	DT	denotes	both
T13621	22666-22674	NNS	denotes	programs
T13622	22685-22689	IN	denotes	that
T13623	22745-22750	VB	denotes	alter
T13624	22690-22692	CD	denotes	15
T13625	22700-22702	CD	denotes	56
T13626	22693-22695	IN	denotes	of
T13627	22696-22699	DT	denotes	the
T13628	22703-22708	NN	denotes	nsSNP
T13629	22709-22711	IN	denotes	in
T13630	22712-22713	CD	denotes	9
T13631	22724-22729	NNS	denotes	genes
T13632	22714-22723	JJ	denotes	different
T13633	22730-22735	MD	denotes	would
T13634	22736-22744	RB	denotes	possibly
T13635	22751-22758	NN	denotes	protein
T13636	22759-22767	NN	denotes	function
T13637	22768-22769	-LRB-	denotes	(
T13638	22769-22774	NN	denotes	Table
T13639	22775-22776	CD	denotes	7
T13640	22776-22777	-RRB-	denotes	)
T13641	22777-22778	.	denotes	.
T17718	22791-22796	NN	denotes	Speed
T17719	22797-22805	JJ	denotes	congenic
T17720	22806-22813	NNS	denotes	strains
T17721	22814-22821	VBP	denotes	provide
T17722	22822-22823	DT	denotes	a
T17723	22833-22841	NN	denotes	approach
T17724	22824-22832	JJ	denotes	powerful
T17725	22842-22844	TO	denotes	to
T17726	22845-22852	VB	denotes	confirm
T17727	22853-22856	CC	denotes	and
T17728	22857-22867	RB	denotes	physically
T17729	22868-22875	VB	denotes	confine
T17730	22876-22879	NN	denotes	QTL
T17731	22880-22886	IN	denotes	within
T17732	22887-22896	NNS	denotes	intervals
T17733	22897-22904	VBN	denotes	defined
T17734	22905-22907	IN	denotes	by
T17735	22908-22917	JJ	denotes	molecular
T17736	22918-22925	NNS	denotes	markers
T17737	22925-22926	.	denotes	.
T17738	22926-23147	sentence	denotes	In the current study, approximately 20% of the CAST genome harboring all previously detected growth and carcass composition QTL was isolated on an HG or B6 background through the development of 14 speed congenic strains.
T17739	22927-22929	IN	denotes	In
T17740	23059-23067	VBN	denotes	isolated
T17741	22930-22933	DT	denotes	the
T17742	22942-22947	NN	denotes	study
T17743	22934-22941	JJ	denotes	current
T17744	22947-22949	,	denotes	,
T17745	22949-22962	RB	denotes	approximately
T17746	22963-22965	CD	denotes	20
T17747	22965-22966	NN	denotes	%
T17748	22967-22969	IN	denotes	of
T17749	22970-22973	DT	denotes	the
T17750	22979-22985	NN	denotes	genome
T17751	22974-22978	NN	denotes	CAST
T17752	22986-22995	VBG	denotes	harboring
T17753	22996-22999	RB	denotes	all
T17754	23051-23054	NN	denotes	QTL
T17755	23000-23010	RB	denotes	previously
T17756	23011-23019	VBN	denotes	detected
T17757	23020-23026	NN	denotes	growth
T17758	23039-23050	NN	denotes	composition
T17759	23027-23030	CC	denotes	and
T17760	23031-23038	NN	denotes	carcass
T17761	23055-23058	VBD	denotes	was
T17762	23068-23070	IN	denotes	on
T17763	23071-23073	DT	denotes	an
T17764	23083-23093	NN	denotes	background
T17765	23074-23076	NN	denotes	HG
T17766	23077-23079	CC	denotes	or
T17767	23080-23082	NN	denotes	B6
T17768	23094-23101	IN	denotes	through
T17769	23102-23105	DT	denotes	the
T17770	23106-23117	NN	denotes	development
T17771	23118-23120	IN	denotes	of
T17772	23121-23123	CD	denotes	14
T17773	23139-23146	NNS	denotes	strains
T17774	23124-23129	NN	denotes	speed
T17775	23130-23138	JJ	denotes	congenic
T17776	23146-23147	.	denotes	.
T17777	23147-23344	sentence	denotes	Two distinct speed congenic panels were developed, the first provided a comprehensive isolation of all MMU2 QTL between the B6, HG and CAST strains and the second targeted all QTL outside of MMU2.
T17778	23148-23151	CD	denotes	Two
T17779	23176-23182	NNS	denotes	panels
T17780	23152-23160	JJ	denotes	distinct
T17781	23161-23166	NN	denotes	speed
T17782	23167-23175	JJ	denotes	congenic
T17783	23188-23197	VBN	denotes	developed
T17784	23183-23187	VBD	denotes	were
T17785	23209-23217	VBD	denotes	provided
T17786	23197-23199	,	denotes	,
T17787	23199-23202	DT	denotes	the
T17788	23203-23208	JJ	denotes	first
T17789	23218-23219	DT	denotes	a
T17790	23234-23243	NN	denotes	isolation
T17791	23220-23233	JJ	denotes	comprehensive
T17792	23244-23246	IN	denotes	of
T17793	23247-23250	DT	denotes	all
T17794	23256-23259	NN	denotes	QTL
T17795	23251-23255	NN	denotes	MMU2
T17796	23260-23267	IN	denotes	between
T17797	23268-23271	DT	denotes	the
T17798	23288-23295	NNS	denotes	strains
T17799	23272-23274	NN	denotes	B6
T17800	23274-23276	,	denotes	,
T17801	23276-23278	NN	denotes	HG
T17802	23279-23282	CC	denotes	and
T17803	23283-23287	NN	denotes	CAST
T17804	23296-23299	CC	denotes	and
T17805	23300-23303	DT	denotes	the
T17806	23304-23310	NN	denotes	second
T17807	23311-23319	VBD	denotes	targeted
T17808	23320-23323	DT	denotes	all
T17809	23324-23327	NN	denotes	QTL
T17810	23328-23335	IN	denotes	outside
T17811	23336-23338	IN	denotes	of
T17812	23339-23343	NN	denotes	MMU2
T17813	23343-23344	.	denotes	.
T17814	23344-23442	sentence	denotes	Each successfully characterized strain exhibited phenotypic differences relative to control mice.
T17815	23345-23349	DT	denotes	Each
T17816	23377-23383	NN	denotes	strain
T17817	23350-23362	RB	denotes	successfully
T17818	23363-23376	VBN	denotes	characterized
T17819	23384-23393	VBD	denotes	exhibited
T17820	23394-23404	JJ	denotes	phenotypic
T17821	23405-23416	NNS	denotes	differences
T17822	23417-23425	JJ	denotes	relative
T17823	23426-23428	IN	denotes	to
T17824	23429-23436	NN	denotes	control
T17825	23437-23441	NNS	denotes	mice
T17826	23441-23442	.	denotes	.
T17827	23442-23576	sentence	denotes	These strains represent important resources and provide the genetic resource to positionally clone numerous quantitative trait genes.
T17828	23443-23448	DT	denotes	These
T17829	23449-23456	NNS	denotes	strains
T17830	23457-23466	VBP	denotes	represent
T17831	23467-23476	JJ	denotes	important
T17832	23477-23486	NNS	denotes	resources
T17833	23487-23490	CC	denotes	and
T17834	23491-23498	VB	denotes	provide
T17835	23499-23502	DT	denotes	the
T17836	23511-23519	NN	denotes	resource
T17837	23503-23510	JJ	denotes	genetic
T17838	23520-23522	TO	denotes	to
T17839	23536-23541	VB	denotes	clone
T17840	23523-23535	RB	denotes	positionally
T17841	23542-23550	JJ	denotes	numerous
T17842	23570-23575	NNS	denotes	genes
T17843	23551-23563	JJ	denotes	quantitative
T17844	23564-23569	NN	denotes	trait
T17845	23575-23576	.	denotes	.
T17846	23576-23721	sentence	denotes	One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.
T17847	23577-23580	CD	denotes	One
T17848	23581-23590	NN	denotes	criticism
T17849	23622-23624	VBZ	denotes	is
T17850	23591-23593	IN	denotes	of
T17851	23594-23597	DT	denotes	the
T17852	23613-23621	NN	denotes	approach
T17853	23598-23603	NN	denotes	speed
T17854	23604-23612	JJ	denotes	congenic
T17855	23625-23628	DT	denotes	the
T17856	23629-23638	NN	denotes	potential
T17857	23639-23642	IN	denotes	for
T17858	23650-23656	VB	denotes	reside
T17859	23643-23646	NN	denotes	QTL
T17860	23647-23649	TO	denotes	to
T17861	23657-23662	IN	denotes	among
T17862	23663-23671	JJ	denotes	unwanted
T17863	23678-23685	NNS	denotes	alleles
T17864	23672-23677	NN	denotes	donor
T17865	23686-23689	RB	denotes	not
T17866	23690-23700	VBN	denotes	eliminated
T17867	23701-23707	IN	denotes	during
T17868	23708-23720	NN	denotes	backcrossing
T17869	23720-23721	.	denotes	.
T17870	23721-23849	sentence	denotes	In this case differences between the congenic and control strains would be due in part or whole to these contaminating alleles.
T17871	23722-23724	IN	denotes	In
T17872	23794-23796	VB	denotes	be
T17873	23725-23729	DT	denotes	this
T17874	23730-23734	NN	denotes	case
T17875	23735-23746	NNS	denotes	differences
T17876	23747-23754	IN	denotes	between
T17877	23755-23758	DT	denotes	the
T17878	23780-23787	NNS	denotes	strains
T17879	23759-23767	JJ	denotes	congenic
T17880	23768-23771	CC	denotes	and
T17881	23772-23779	NN	denotes	control
T17882	23788-23793	MD	denotes	would
T17883	23797-23800	IN	denotes	due
T17884	23801-23803	IN	denotes	in
T17885	23804-23808	NN	denotes	part
T17886	23809-23811	CC	denotes	or
T17887	23812-23817	NN	denotes	whole
T17888	23818-23820	IN	denotes	to
T17889	23821-23826	DT	denotes	these
T17890	23841-23848	NNS	denotes	alleles
T17891	23827-23840	VBG	denotes	contaminating
T17892	23848-23849	.	denotes	.
T17893	23849-23923	sentence	denotes	We took several precautions to reduce the probability of this occurrence.
T17894	23850-23852	PRP	denotes	We
T17895	23853-23857	VBD	denotes	took
T17896	23858-23865	JJ	denotes	several
T17897	23866-23877	NNS	denotes	precautions
T17898	23878-23880	TO	denotes	to
T17899	23881-23887	VB	denotes	reduce
T17900	23888-23891	DT	denotes	the
T17901	23892-23903	NN	denotes	probability
T17902	23904-23906	IN	denotes	of
T17903	23907-23911	DT	denotes	this
T17904	23912-23922	NN	denotes	occurrence
T17905	23922-23923	.	denotes	.
T17906	23923-24036	sentence	denotes	First, our control strains were developed from mice undergoing the same selection as all of the other congenics.
T17907	23924-23929	RB	denotes	First
T17908	23956-23965	VBN	denotes	developed
T17909	23929-23931	,	denotes	,
T17910	23931-23934	PRP$	denotes	our
T17911	23943-23950	NNS	denotes	strains
T17912	23935-23942	NN	denotes	control
T17913	23951-23955	VBD	denotes	were
T17914	23966-23970	IN	denotes	from
T17915	23971-23975	NNS	denotes	mice
T17916	23976-23986	VBG	denotes	undergoing
T17917	23987-23990	DT	denotes	the
T17918	23996-24005	NN	denotes	selection
T17919	23991-23995	JJ	denotes	same
T17920	24006-24008	IN	denotes	as
T17921	24009-24012	DT	denotes	all
T17922	24013-24015	IN	denotes	of
T17923	24016-24019	DT	denotes	the
T17924	24026-24035	NNS	denotes	congenics
T17925	24020-24025	JJ	denotes	other
T17926	24035-24036	.	denotes	.
T17927	24036-24166	sentence	denotes	Therefore, it is possible that any unwanted QTL or mutations arising during congenic construction are shared between all strains.
T17928	24037-24046	RB	denotes	Therefore
T17929	24051-24053	VBZ	denotes	is
T17930	24046-24048	,	denotes	,
T17931	24048-24050	PRP	denotes	it
T17932	24054-24062	JJ	denotes	possible
T17933	24063-24067	IN	denotes	that
T17934	24139-24145	VBN	denotes	shared
T17935	24068-24071	DT	denotes	any
T17936	24081-24084	NN	denotes	QTL
T17937	24072-24080	JJ	denotes	unwanted
T17938	24085-24087	CC	denotes	or
T17939	24088-24097	NNS	denotes	mutations
T17940	24098-24105	VBG	denotes	arising
T17941	24106-24112	IN	denotes	during
T17942	24113-24121	JJ	denotes	congenic
T17943	24122-24134	NN	denotes	construction
T17944	24135-24138	VBP	denotes	are
T17945	24146-24153	IN	denotes	between
T17946	24154-24157	DT	denotes	all
T17947	24158-24165	NNS	denotes	strains
T17948	24165-24166	.	denotes	.
T17949	24166-24285	sentence	denotes	More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24].
T17950	24167-24171	RBR	denotes	More
T17951	24172-24183	RB	denotes	importantly
T17952	24188-24192	VBP	denotes	have
T17953	24183-24185	,	denotes	,
T17954	24185-24187	PRP	denotes	we
T17955	24193-24202	NN	denotes	knowledge
T17956	24203-24205	IN	denotes	of
T17957	24206-24209	DT	denotes	all
T17958	24255-24258	NN	denotes	QTL
T17959	24210-24215	JJ	denotes	large
T17960	24216-24226	RB	denotes	previously
T17961	24227-24235	VBN	denotes	detected
T17962	24236-24242	NN	denotes	growth
T17963	24243-24246	CC	denotes	and
T17964	24247-24254	NN	denotes	obesity
T17965	24259-24261	IN	denotes	in
T17966	24262-24265	DT	denotes	the
T17967	24274-24279	NN	denotes	cross
T17968	24266-24273	JJ	denotes	current
T17969	24280-24281	-LRB-	denotes	[
T17970	24281-24283	CD	denotes	24
T17971	24283-24284	-RRB-	denotes	]
T17972	24284-24285	.	denotes	.
T17973	24285-24484	sentence	denotes	Using this information we increased the density of markers in each QTL region (MMU1, 2, 5, 8, 9, 11 and 17; Table 1 and Additional File 1), ensuring the absence of CAST alleles at each of these QTL.
T17974	24286-24291	VBG	denotes	Using
T17975	24312-24321	VBD	denotes	increased
T17976	24292-24296	DT	denotes	this
T17977	24297-24308	NN	denotes	information
T17978	24309-24311	PRP	denotes	we
T17979	24322-24325	DT	denotes	the
T17980	24326-24333	NN	denotes	density
T17981	24334-24336	IN	denotes	of
T17982	24337-24344	NNS	denotes	markers
T17983	24345-24347	IN	denotes	in
T17984	24348-24352	DT	denotes	each
T17985	24357-24363	NN	denotes	region
T17986	24353-24356	NN	denotes	QTL
T17987	24364-24365	-LRB-	denotes	(
T17988	24394-24399	NN	denotes	Table
T17989	24365-24368	NN	denotes	MMU
T17990	24368-24369	CD	denotes	1
T17991	24369-24371	,	denotes	,
T17992	24371-24372	CD	denotes	2
T17993	24372-24374	,	denotes	,
T17994	24374-24375	CD	denotes	5
T17995	24375-24377	,	denotes	,
T17996	24377-24378	CD	denotes	8
T17997	24378-24380	,	denotes	,
T17998	24380-24381	CD	denotes	9
T17999	24381-24383	,	denotes	,
T18000	24383-24385	CD	denotes	11
T18001	24386-24389	CC	denotes	and
T18002	24390-24392	CD	denotes	17
T18003	24392-24393	:	denotes	;
T18004	24400-24401	CD	denotes	1
T18005	24402-24405	CC	denotes	and
T18006	24406-24416	JJ	denotes	Additional
T18007	24417-24421	NN	denotes	File
T18008	24422-24423	CD	denotes	1
T18009	24423-24424	-RRB-	denotes	)
T18010	24424-24426	,	denotes	,
T18011	24426-24434	VBG	denotes	ensuring
T18012	24435-24438	DT	denotes	the
T18013	24439-24446	NN	denotes	absence
T18014	24447-24449	IN	denotes	of
T18015	24450-24454	NN	denotes	CAST
T18016	24455-24462	NNS	denotes	alleles
T18017	24463-24465	IN	denotes	at
T18018	24466-24470	DT	denotes	each
T18019	24471-24473	IN	denotes	of
T18020	24474-24479	DT	denotes	these
T18021	24480-24483	NN	denotes	QTL
T18022	24483-24484	.	denotes	.
T18023	24484-24643	sentence	denotes	This approach, termed "QTL-Marker-Assisted Counter Selection" or QMACS, has been previously used to characterize QTL for hypnotic sensitivity to ethanol [31].
T18024	24485-24489	DT	denotes	This
T18025	24490-24498	NN	denotes	approach
T18026	24577-24581	VBN	denotes	used
T18027	24498-24500	,	denotes	,
T18028	24500-24506	VBN	denotes	termed
T18029	24507-24508	``	denotes	"
T18030	24508-24511	NN	denotes	QTL
T18031	24512-24518	NN	denotes	Marker
T18032	24511-24512	HYPH	denotes	-
T18033	24519-24527	VBN	denotes	Assisted
T18034	24518-24519	HYPH	denotes	-
T18035	24536-24545	NN	denotes	Selection
T18036	24528-24535	NN	denotes	Counter
T18037	24545-24546	''	denotes	"
T18038	24547-24549	CC	denotes	or
T18039	24550-24555	NN	denotes	QMACS
T18040	24555-24557	,	denotes	,
T18041	24557-24560	VBZ	denotes	has
T18042	24561-24565	VBN	denotes	been
T18043	24566-24576	RB	denotes	previously
T18044	24582-24584	TO	denotes	to
T18045	24585-24597	VB	denotes	characterize
T18046	24598-24601	NN	denotes	QTL
T18047	24602-24605	IN	denotes	for
T18048	24606-24614	JJ	denotes	hypnotic
T18049	24615-24626	NN	denotes	sensitivity
T18050	24627-24629	IN	denotes	to
T18051	24630-24637	NN	denotes	ethanol
T18052	24638-24639	-LRB-	denotes	[
T18053	24639-24641	CD	denotes	31
T18054	24641-24642	-RRB-	denotes	]
T18055	24642-24643	.	denotes	.
T18056	24643-24721	sentence	denotes	In that study, only markers flanking QTL were typed, not genome-wide markers.
T18057	24644-24646	IN	denotes	In
T18058	24690-24695	VBN	denotes	typed
T18059	24647-24651	DT	denotes	that
T18060	24652-24657	NN	denotes	study
T18061	24657-24659	,	denotes	,
T18062	24659-24663	RB	denotes	only
T18063	24664-24671	NNS	denotes	markers
T18064	24672-24680	VBG	denotes	flanking
T18065	24681-24684	NN	denotes	QTL
T18066	24685-24689	VBD	denotes	were
T18067	24695-24697	,	denotes	,
T18068	24697-24700	CC	denotes	not
T18069	24713-24720	NNS	denotes	markers
T18070	24701-24707	NN	denotes	genome
T18071	24708-24712	JJ	denotes	wide
T18072	24707-24708	HYPH	denotes	-
T18073	24720-24721	.	denotes	.
T18074	24721-24926	sentence	denotes	In contrast, we selected not only against known QTL, we also screened for genome wide heterozygosity increasing the probability that effects observed are due to genetic variation within each donor region.
T18075	24722-24724	IN	denotes	In
T18076	24783-24791	VBD	denotes	screened
T18077	24725-24733	NN	denotes	contrast
T18078	24733-24735	,	denotes	,
T18079	24735-24737	PRP	denotes	we
T18080	24738-24746	VBD	denotes	selected
T18081	24747-24750	RB	denotes	not
T18082	24751-24755	RB	denotes	only
T18083	24756-24763	IN	denotes	against
T18084	24764-24769	VBN	denotes	known
T18085	24770-24773	NN	denotes	QTL
T18086	24773-24775	,	denotes	,
T18087	24775-24777	PRP	denotes	we
T18088	24778-24782	RB	denotes	also
T18089	24792-24795	IN	denotes	for
T18090	24796-24802	NN	denotes	genome
T18091	24803-24807	JJ	denotes	wide
T18092	24808-24822	NN	denotes	heterozygosity
T18093	24823-24833	VBG	denotes	increasing
T18094	24834-24837	DT	denotes	the
T18095	24838-24849	NN	denotes	probability
T18096	24850-24854	IN	denotes	that
T18097	24872-24875	VBP	denotes	are
T18098	24855-24862	NNS	denotes	effects
T18099	24863-24871	VBN	denotes	observed
T18100	24876-24879	IN	denotes	due
T18101	24880-24882	IN	denotes	to
T18102	24883-24890	JJ	denotes	genetic
T18103	24891-24900	NN	denotes	variation
T18104	24901-24907	IN	denotes	within
T18105	24908-24912	DT	denotes	each
T18106	24919-24925	NN	denotes	region
T18107	24913-24918	NN	denotes	donor
T18108	24925-24926	.	denotes	.
T18109	24926-25177	sentence	denotes	Although great effort was put forth to eliminate non-donor region direct genetic effects, other factors such as maternal genotype (maternal genotype for each congenic versus control dams differed) and environmental effects could confound our results.
T18110	24927-24935	IN	denotes	Although
T18111	24953-24956	VBN	denotes	put
T18112	24936-24941	JJ	denotes	great
T18113	24942-24948	NN	denotes	effort
T18114	24949-24952	VBD	denotes	was
T18115	25156-25164	VB	denotes	confound
T18116	24957-24962	RP	denotes	forth
T18117	24963-24965	TO	denotes	to
T18118	24966-24975	VB	denotes	eliminate
T18119	24976-24985	JJ	denotes	non-donor
T18120	24986-24992	NN	denotes	region
T18121	25008-25015	NNS	denotes	effects
T18122	24993-24999	JJ	denotes	direct
T18123	25000-25007	JJ	denotes	genetic
T18124	25015-25017	,	denotes	,
T18125	25017-25022	JJ	denotes	other
T18126	25023-25030	NNS	denotes	factors
T18127	25031-25035	JJ	denotes	such
T18128	25036-25038	IN	denotes	as
T18129	25039-25047	JJ	denotes	maternal
T18130	25048-25056	NN	denotes	genotype
T18131	25057-25058	-LRB-	denotes	(
T18132	25114-25122	VBD	denotes	differed
T18133	25058-25066	JJ	denotes	maternal
T18134	25067-25075	NN	denotes	genotype
T18135	25076-25079	IN	denotes	for
T18136	25080-25084	DT	denotes	each
T18137	25085-25093	JJ	denotes	congenic
T18138	25094-25100	CC	denotes	versus
T18139	25101-25108	NN	denotes	control
T18140	25109-25113	NNS	denotes	dams
T18141	25122-25123	-RRB-	denotes	)
T18142	25124-25127	CC	denotes	and
T18143	25128-25141	JJ	denotes	environmental
T18144	25142-25149	NNS	denotes	effects
T18145	25150-25155	MD	denotes	could
T18146	25165-25168	PRP$	denotes	our
T18147	25169-25176	NNS	denotes	results
T18148	25176-25177	.	denotes	.
T18149	25177-25346	sentence	denotes	Maternal genotype effects on growth and obesity have been observed in a number of mouse crosses [8,32-35] and their existence in the current cross cannot be discounted.
T18150	25178-25186	JJ	denotes	Maternal
T18151	25187-25195	NN	denotes	genotype
T18152	25196-25203	NNS	denotes	effects
T18153	25236-25244	VBN	denotes	observed
T18154	25204-25206	IN	denotes	on
T18155	25207-25213	NN	denotes	growth
T18156	25214-25217	CC	denotes	and
T18157	25218-25225	NN	denotes	obesity
T18158	25226-25230	VBP	denotes	have
T18159	25231-25235	VBN	denotes	been
T18160	25245-25247	IN	denotes	in
T18161	25248-25249	DT	denotes	a
T18162	25250-25256	NN	denotes	number
T18163	25257-25259	IN	denotes	of
T18164	25260-25265	NN	denotes	mouse
T18165	25266-25273	NNS	denotes	crosses
T18166	25274-25275	-LRB-	denotes	[
T18167	25275-25276	CD	denotes	8
T18168	25276-25277	,	denotes	,
T18169	25277-25279	CD	denotes	32
T18170	25279-25280	SYM	denotes	-
T18171	25280-25282	CD	denotes	35
T18172	25282-25283	-RRB-	denotes	]
T18173	25284-25287	CC	denotes	and
T18174	25288-25293	PRP$	denotes	their
T18175	25294-25303	NN	denotes	existence
T18176	25335-25345	VBN	denotes	discounted
T18177	25304-25306	IN	denotes	in
T18178	25307-25310	DT	denotes	the
T18179	25319-25324	NN	denotes	cross
T18180	25311-25318	JJ	denotes	current
T18181	25325-25328	MD	denotes	can
T18182	25328-25331	RB	denotes	not
T18183	25332-25334	VB	denotes	be
T18184	25345-25346	.	denotes	.
T18185	25346-25475	sentence	denotes	However, our congenics provide the ideal foundation genomic resource to test for the influence of any of these possible effects.
T18186	25347-25354	RB	denotes	However
T18187	25370-25377	VBP	denotes	provide
T18188	25354-25356	,	denotes	,
T18189	25356-25359	PRP$	denotes	our
T18190	25360-25369	NNS	denotes	congenics
T18191	25378-25381	DT	denotes	the
T18192	25407-25415	NN	denotes	resource
T18193	25382-25387	JJ	denotes	ideal
T18194	25388-25398	NN	denotes	foundation
T18195	25399-25406	JJ	denotes	genomic
T18196	25416-25418	TO	denotes	to
T18197	25419-25423	VB	denotes	test
T18198	25424-25427	IN	denotes	for
T18199	25428-25431	DT	denotes	the
T18200	25432-25441	NN	denotes	influence
T18201	25442-25444	IN	denotes	of
T18202	25445-25448	DT	denotes	any
T18203	25449-25451	IN	denotes	of
T18204	25452-25457	DT	denotes	these
T18205	25467-25474	NNS	denotes	effects
T18206	25458-25466	JJ	denotes	possible
T18207	25474-25475	.	denotes	.
T18208	25475-25664	sentence	denotes	Future fine mapping experiments can be designed to randomize the influences of any contaminating donor alleles and environmental differences, as well as test for maternal genotype effects.
T18209	25476-25482	JJ	denotes	Future
T18210	25496-25507	NNS	denotes	experiments
T18211	25483-25487	JJ	denotes	fine
T18212	25488-25495	NN	denotes	mapping
T18213	25515-25523	VBN	denotes	designed
T18214	25508-25511	MD	denotes	can
T18215	25512-25514	VB	denotes	be
T18216	25524-25526	TO	denotes	to
T18217	25527-25536	VB	denotes	randomize
T18218	25537-25540	DT	denotes	the
T18219	25541-25551	NNS	denotes	influences
T18220	25552-25554	IN	denotes	of
T18221	25555-25558	DT	denotes	any
T18222	25579-25586	NNS	denotes	alleles
T18223	25559-25572	VBG	denotes	contaminating
T18224	25573-25578	NN	denotes	donor
T18225	25587-25590	CC	denotes	and
T18226	25591-25604	JJ	denotes	environmental
T18227	25605-25616	NNS	denotes	differences
T18228	25616-25618	,	denotes	,
T18229	25618-25620	RB	denotes	as
T18230	25626-25628	IN	denotes	as
T18231	25621-25625	RB	denotes	well
T18232	25629-25633	VB	denotes	test
T18233	25634-25637	IN	denotes	for
T18234	25638-25646	JJ	denotes	maternal
T18235	25647-25655	NN	denotes	genotype
T18236	25656-25663	NNS	denotes	effects
T18237	25663-25664	.	denotes	.
T18238	25664-25710	sentence	denotes	MMU2 is a hotspot for growth and obesity QTL.
T18239	25665-25669	NN	denotes	MMU2
T18240	25670-25672	VBZ	denotes	is
T18241	25673-25674	DT	denotes	a
T18242	25675-25682	NN	denotes	hotspot
T18243	25683-25686	IN	denotes	for
T18244	25687-25693	NN	denotes	growth
T18245	25706-25709	NN	denotes	QTL
T18246	25694-25697	CC	denotes	and
T18247	25698-25705	NN	denotes	obesity
T18248	25709-25710	.	denotes	.
T18249	25710-25773	sentence	denotes	Over 30 QTL have been identified in various experiments [1,2].
T18250	25711-25715	IN	denotes	Over
T18251	25716-25718	CD	denotes	30
T18252	25719-25722	NN	denotes	QTL
T18253	25733-25743	VBN	denotes	identified
T18254	25723-25727	VBP	denotes	have
T18255	25728-25732	VBN	denotes	been
T18256	25744-25746	IN	denotes	in
T18257	25747-25754	JJ	denotes	various
T18258	25755-25766	NNS	denotes	experiments
T18259	25767-25768	-LRB-	denotes	[
T18260	25770-25771	CD	denotes	2
T18261	25768-25769	CD	denotes	1
T18262	25769-25770	,	denotes	,
T18263	25771-25772	-RRB-	denotes	]
T18264	25772-25773	.	denotes	.
T18265	25773-25892	sentence	denotes	Several previously reported or novel MMU2 QTL have been isolated and characterized using congenic strains [7,9-11,36].
T18266	25774-25781	JJ	denotes	Several
T18267	25816-25819	NN	denotes	QTL
T18268	25782-25792	RB	denotes	previously
T18269	25793-25801	VBN	denotes	reported
T18270	25802-25804	CC	denotes	or
T18271	25805-25810	JJ	denotes	novel
T18272	25811-25815	NN	denotes	MMU2
T18273	25830-25838	VBN	denotes	isolated
T18274	25820-25824	VBP	denotes	have
T18275	25825-25829	VBN	denotes	been
T18276	25839-25842	CC	denotes	and
T18277	25843-25856	VBN	denotes	characterized
T18278	25857-25862	VBG	denotes	using
T18279	25863-25871	JJ	denotes	congenic
T18280	25872-25879	NNS	denotes	strains
T18281	25880-25881	-LRB-	denotes	[
T18282	25881-25882	CD	denotes	7
T18283	25882-25883	,	denotes	,
T18284	25883-25884	CD	denotes	9
T18285	25884-25885	SYM	denotes	-
T18286	25885-25887	CD	denotes	11
T18287	25887-25888	,	denotes	,
T18288	25888-25890	CD	denotes	36
T18289	25890-25891	-RRB-	denotes	]
T18290	25891-25892	.	denotes	.
T18291	25892-26015	sentence	denotes	Our findings are no different and indicate that MMU2 is highly complex with regards to genes affecting growth and obesity.
T18292	25893-25896	PRP$	denotes	Our
T18293	25897-25905	NNS	denotes	findings
T18294	25906-25909	VBP	denotes	are
T18295	25910-25912	DT	denotes	no
T18296	25913-25922	JJ	denotes	different
T18297	25923-25926	CC	denotes	and
T18298	25927-25935	VBP	denotes	indicate
T18299	25936-25940	IN	denotes	that
T18300	25946-25948	VBZ	denotes	is
T18301	25941-25945	NN	denotes	MMU2
T18302	25949-25955	RB	denotes	highly
T18303	25956-25963	JJ	denotes	complex
T18304	25964-25968	IN	denotes	with
T18305	25969-25976	NNS	denotes	regards
T18306	25977-25979	IN	denotes	to
T18307	25980-25985	NNS	denotes	genes
T18308	25986-25995	VBG	denotes	affecting
T18309	25996-26002	NN	denotes	growth
T18310	26003-26006	CC	denotes	and
T18311	26007-26014	NN	denotes	obesity
T18312	26014-26015	.	denotes	.
T18313	26015-26137	sentence	denotes	The overlapping nature of our MMU2 strains allowed us to parse the chromosome into five regions (Regions I–V) (Figure 2).
T18314	26016-26019	DT	denotes	The
T18315	26032-26038	NN	denotes	nature
T18316	26020-26031	VBG	denotes	overlapping
T18317	26059-26066	VBD	denotes	allowed
T18318	26039-26041	IN	denotes	of
T18319	26042-26045	PRP$	denotes	our
T18320	26051-26058	NNS	denotes	strains
T18321	26046-26050	NN	denotes	MMU2
T18322	26067-26069	PRP	denotes	us
T18323	26073-26078	VB	denotes	parse
T18324	26070-26072	TO	denotes	to
T18325	26079-26082	DT	denotes	the
T18326	26083-26093	NN	denotes	chromosome
T18327	26094-26098	IN	denotes	into
T18328	26099-26103	CD	denotes	five
T18329	26104-26111	NNS	denotes	regions
T18330	26112-26113	-LRB-	denotes	(
T18331	26113-26120	NNS	denotes	Regions
T18332	26121-26122	CD	denotes	I
T18333	26122-26123	SYM	denotes	–
T18334	26123-26124	CD	denotes	V
T18335	26124-26125	-RRB-	denotes	)
T18336	26126-26127	-LRB-	denotes	(
T18337	26127-26133	NN	denotes	Figure
T18338	26134-26135	CD	denotes	2
T22853	38210-38220	VBG	denotes	continuing
T18371	26273-26279	NN	denotes	growth
T22854	38221-38228	IN	denotes	through
T18372	26280-26283	CC	denotes	and
T18373	26284-26291	NN	denotes	obesity
T22855	38229-38231	NN	denotes	N6
T18374	26291-26293	,	denotes	,
T18375	26293-26301	IN	denotes	although
T18376	26302-26304	IN	denotes	to
T18339	26135-26136	-RRB-	denotes	)
T18340	26136-26137	.	denotes	.
T18341	26137-26227	sentence	denotes	The data support the presence of at least one QTL in each of the five regions (Figure 2).
T18342	26138-26141	DT	denotes	The
T18343	26142-26146	NNS	denotes	data
T18344	26147-26154	VBP	denotes	support
T18345	26155-26158	DT	denotes	the
T18346	26159-26167	NN	denotes	presence
T18347	26168-26170	IN	denotes	of
T18348	26171-26173	RB	denotes	at
T18349	26180-26183	CD	denotes	one
T18350	26174-26179	RBS	denotes	least
T18351	26184-26187	NN	denotes	QTL
T18352	26188-26190	IN	denotes	in
T18353	26191-26195	DT	denotes	each
T18354	26196-26198	IN	denotes	of
T18355	26199-26202	DT	denotes	the
T18356	26208-26215	NNS	denotes	regions
T18357	26203-26207	CD	denotes	five
T18358	26216-26217	-LRB-	denotes	(
T18359	26217-26223	NN	denotes	Figure
T18360	26224-26225	CD	denotes	2
T18361	26225-26226	-RRB-	denotes	)
T18362	26226-26227	.	denotes	.
T18363	26227-26321	sentence	denotes	Each of the five pleiotropically impact both growth and obesity, although to varying degrees.
T18364	26228-26232	DT	denotes	Each
T18365	26261-26267	VBP	denotes	impact
T18366	26233-26235	IN	denotes	of
T18367	26236-26239	DT	denotes	the
T18368	26240-26244	CD	denotes	five
T18369	26245-26260	RB	denotes	pleiotropically
T18370	26268-26272	CC	denotes	both
T18377	26305-26312	VBG	denotes	varying
T18378	26313-26320	NNS	denotes	degrees
T18379	26320-26321	.	denotes	.
T18380	26321-26496	sentence	denotes	In addition to the large number of MMU2 QTL, the presence of hg adds complexity by either eliciting interactions with the same QTL or by inducing the expression of novel QTL.
T18381	26322-26324	IN	denotes	In
T18382	26386-26390	VBZ	denotes	adds
T18383	26325-26333	NN	denotes	addition
T18384	26334-26336	IN	denotes	to
T18385	26337-26340	DT	denotes	the
T18386	26347-26353	NN	denotes	number
T18387	26341-26346	JJ	denotes	large
T18388	26354-26356	IN	denotes	of
T18389	26357-26361	NN	denotes	MMU2
T18390	26362-26365	NN	denotes	QTL
T18391	26365-26367	,	denotes	,
T18392	26367-26370	DT	denotes	the
T18393	26371-26379	NN	denotes	presence
T18394	26380-26382	IN	denotes	of
T18395	26383-26385	NN	denotes	hg
T18396	26391-26401	NN	denotes	complexity
T18397	26402-26404	IN	denotes	by
T18398	26405-26411	CC	denotes	either
T18399	26412-26421	VBG	denotes	eliciting
T18400	26422-26434	NNS	denotes	interactions
T18401	26435-26439	IN	denotes	with
T18402	26440-26443	DT	denotes	the
T18403	26449-26452	NN	denotes	QTL
T18404	26444-26448	JJ	denotes	same
T18405	26453-26455	CC	denotes	or
T18406	26456-26458	IN	denotes	by
T18407	26459-26467	VBG	denotes	inducing
T18408	26468-26471	DT	denotes	the
T18409	26472-26482	NN	denotes	expression
T18410	26483-26485	IN	denotes	of
T18411	26486-26491	JJ	denotes	novel
T18412	26492-26495	NN	denotes	QTL
T18413	26495-26496	.	denotes	.
T18414	26496-26623	sentence	denotes	The 2P unique region (Region I) contains an hg modifier with large effects on growth and smaller effects on obesity (Table 3).
T18415	26497-26500	DT	denotes	The
T18416	26511-26517	NN	denotes	region
T18417	26501-26503	NN	denotes	2P
T18418	26504-26510	JJ	denotes	unique
T18419	26529-26537	VBZ	denotes	contains
T18420	26518-26519	-LRB-	denotes	(
T18421	26519-26525	NN	denotes	Region
T18422	26526-26527	CD	denotes	I
T18423	26527-26528	-RRB-	denotes	)
T18424	26538-26540	DT	denotes	an
T18425	26544-26552	NN	denotes	modifier
T18426	26541-26543	NN	denotes	hg
T18427	26553-26557	IN	denotes	with
T18428	26558-26563	JJ	denotes	large
T18429	26564-26571	NNS	denotes	effects
T18430	26572-26574	IN	denotes	on
T18431	26575-26581	NN	denotes	growth
T18432	26582-26585	CC	denotes	and
T18433	26586-26593	JJR	denotes	smaller
T18434	26594-26601	NNS	denotes	effects
T18435	26602-26604	IN	denotes	on
T18436	26605-26612	NN	denotes	obesity
T18437	26613-26614	-LRB-	denotes	(
T18438	26614-26619	NN	denotes	Table
T18439	26620-26621	CD	denotes	3
T18440	26621-26622	-RRB-	denotes	)
T18441	26622-26623	.	denotes	.
T18442	26623-26718	sentence	denotes	In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).
T18443	26624-26626	IN	denotes	In
T18444	26686-26692	VBP	denotes	affect
T18445	26627-26635	NN	denotes	contrast
T18446	26635-26637	,	denotes	,
T18447	26637-26649	NNS	denotes	interactions
T18448	26650-26657	IN	denotes	between
T18449	26658-26661	NN	denotes	2PM
T18450	26662-26664	NN	denotes	2M
T18451	26661-26662	HYPH	denotes	/
T18452	26665-26668	NN	denotes	QTL
T18453	26669-26672	CC	denotes	and
T18454	26673-26675	NN	denotes	hg
T18455	26676-26685	RB	denotes	primarily
T18456	26693-26696	NN	denotes	fat
T18457	26697-26707	NN	denotes	deposition
T18458	26708-26709	-LRB-	denotes	(
T18459	26709-26714	NN	denotes	Table
T18460	26715-26716	CD	denotes	3
T18461	26716-26717	-RRB-	denotes	)
T18462	26717-26718	.	denotes	.
T18463	26718-26848	sentence	denotes	As illustrated in Figure 4 the 2M donor region exhibits strong sex effects on the rate of lipid storage, dependent on background.
T18464	26719-26721	IN	denotes	As
T18465	26722-26733	VBN	denotes	illustrated
T18466	26766-26774	VBZ	denotes	exhibits
T18467	26734-26736	IN	denotes	in
T18468	26737-26743	NN	denotes	Figure
T18469	26744-26745	CD	denotes	4
T18470	26746-26749	DT	denotes	the
T18471	26759-26765	NN	denotes	region
T18472	26750-26752	NN	denotes	2M
T18473	26753-26758	NN	denotes	donor
T18474	26775-26781	JJ	denotes	strong
T18475	26786-26793	NNS	denotes	effects
T18476	26782-26785	NN	denotes	sex
T18477	26794-26796	IN	denotes	on
T18478	26797-26800	DT	denotes	the
T18479	26801-26805	NN	denotes	rate
T18480	26806-26808	IN	denotes	of
T18481	26809-26814	NN	denotes	lipid
T18482	26815-26822	NN	denotes	storage
T18483	26822-26824	,	denotes	,
T18484	26824-26833	JJ	denotes	dependent
T18485	26834-26836	IN	denotes	on
T18486	26837-26847	NN	denotes	background
T18487	26847-26848	.	denotes	.
T18488	26848-26946	sentence	denotes	In control mice, HGC females have a higher AI than males, while the opposite is seen in B6C mice.
T18489	26849-26851	IN	denotes	In
T18490	26878-26882	VBP	denotes	have
T18491	26852-26859	NN	denotes	control
T18492	26860-26864	NNS	denotes	mice
T18493	26864-26866	,	denotes	,
T18494	26866-26869	NN	denotes	HGC
T18495	26870-26877	NNS	denotes	females
T18496	26883-26884	DT	denotes	a
T18497	26892-26894	NN	denotes	AI
T18498	26885-26891	JJR	denotes	higher
T18499	26895-26899	IN	denotes	than
T18500	26900-26905	NNS	denotes	males
T18501	26905-26907	,	denotes	,
T18502	26907-26912	IN	denotes	while
T18503	26929-26933	VBN	denotes	seen
T18504	26913-26916	DT	denotes	the
T18505	26917-26925	NN	denotes	opposite
T18506	26926-26928	VBZ	denotes	is
T18507	26934-26936	IN	denotes	in
T18508	26937-26940	NN	denotes	B6C
T18509	26941-26945	NNS	denotes	mice
T18510	26945-26946	.	denotes	.
T18511	26946-27052	sentence	denotes	Interestingly, the 2M hg modifier QTL abolished the hg induced sexual dimorphism in adiposity (Figure 4).
T18512	26947-26960	RB	denotes	Interestingly
T18513	26985-26994	VBD	denotes	abolished
T18514	26960-26962	,	denotes	,
T18515	26962-26965	DT	denotes	the
T18516	26981-26984	NN	denotes	QTL
T18517	26966-26968	NN	denotes	2M
T18518	26969-26971	NN	denotes	hg
T18519	26972-26980	NN	denotes	modifier
T18520	26995-26998	DT	denotes	the
T18521	27017-27027	NN	denotes	dimorphism
T18522	26999-27001	NN	denotes	hg
T18523	27002-27009	VBN	denotes	induced
T18524	27010-27016	JJ	denotes	sexual
T18525	27028-27030	IN	denotes	in
T18526	27031-27040	NN	denotes	adiposity
T18527	27041-27042	-LRB-	denotes	(
T18528	27042-27048	NN	denotes	Figure
T18529	27049-27050	CD	denotes	4
T18530	27050-27051	-RRB-	denotes	)
T18531	27051-27052	.	denotes	.
T18532	27052-27217	sentence	denotes	Although these results provide insight into the nature of hg modifier QTL, it should be noted, that the actual number and precise location of loci is still unclear.
T18533	27053-27061	IN	denotes	Although
T18534	27076-27083	VBP	denotes	provide
T18535	27062-27067	DT	denotes	these
T18536	27068-27075	NNS	denotes	results
T18537	27141-27146	VBN	denotes	noted
T18538	27084-27091	NN	denotes	insight
T18539	27092-27096	IN	denotes	into
T18540	27097-27100	DT	denotes	the
T18541	27101-27107	NN	denotes	nature
T18542	27108-27110	IN	denotes	of
T18543	27111-27113	NN	denotes	hg
T18544	27114-27122	NN	denotes	modifier
T18545	27123-27126	NN	denotes	QTL
T18546	27126-27128	,	denotes	,
T18547	27128-27130	PRP	denotes	it
T18548	27131-27137	MD	denotes	should
T18549	27138-27140	VB	denotes	be
T18550	27146-27148	,	denotes	,
T18551	27148-27152	IN	denotes	that
T18552	27200-27202	VBZ	denotes	is
T18553	27153-27156	DT	denotes	the
T18554	27164-27170	NN	denotes	number
T18555	27157-27163	JJ	denotes	actual
T18556	27171-27174	CC	denotes	and
T18557	27175-27182	JJ	denotes	precise
T18558	27183-27191	NN	denotes	location
T18559	27192-27194	IN	denotes	of
T18560	27195-27199	NNS	denotes	loci
T18561	27203-27208	RB	denotes	still
T18562	27209-27216	JJ	denotes	unclear
T18563	27216-27217	.	denotes	.
T18564	27217-27307	sentence	denotes	In addition to MMU2, three other congenics (HG9, HG11 and HG17) captured hg modifier QTL.
T18565	27218-27220	IN	denotes	In
T18566	27282-27290	VBD	denotes	captured
T18567	27221-27229	NN	denotes	addition
T18568	27230-27232	IN	denotes	to
T18569	27233-27237	NN	denotes	MMU2
T18570	27237-27239	,	denotes	,
T18571	27239-27244	CD	denotes	three
T18572	27251-27260	NNS	denotes	congenics
T18573	27245-27250	JJ	denotes	other
T18574	27261-27262	-LRB-	denotes	(
T18575	27262-27265	NN	denotes	HG9
T18576	27265-27267	,	denotes	,
T18577	27267-27271	NN	denotes	HG11
T18578	27272-27275	CC	denotes	and
T18579	27276-27280	NN	denotes	HG17
T18580	27280-27281	-RRB-	denotes	)
T18581	27291-27293	NN	denotes	hg
T18582	27294-27302	NN	denotes	modifier
T18583	27303-27306	NN	denotes	QTL
T18584	27306-27307	.	denotes	.
T18585	27307-27409	sentence	denotes	In classical terms, they are QTL which modify the expressivity of growth and obesity in HG mice [18].
T18586	27308-27310	IN	denotes	In
T18587	27333-27336	VBP	denotes	are
T18588	27311-27320	JJ	denotes	classical
T18589	27321-27326	NNS	denotes	terms
T18590	27326-27328	,	denotes	,
T18591	27328-27332	PRP	denotes	they
T18592	27337-27340	NN	denotes	QTL
T18593	27341-27346	WDT	denotes	which
T18594	27347-27353	VBP	denotes	modify
T18595	27354-27357	DT	denotes	the
T18596	27358-27370	NN	denotes	expressivity
T18597	27371-27373	IN	denotes	of
T18598	27374-27380	NN	denotes	growth
T18599	27381-27384	CC	denotes	and
T18600	27385-27392	NN	denotes	obesity
T18601	27393-27395	IN	denotes	in
T18602	27396-27398	NN	denotes	HG
T18603	27399-27403	NNS	denotes	mice
T18604	27404-27405	-LRB-	denotes	[
T18605	27405-27407	CD	denotes	18
T18606	27407-27408	-RRB-	denotes	]
T18607	27408-27409	.	denotes	.
T18608	27409-27494	sentence	denotes	These QTL are novel since they represent epistasis between hg and the modifier gene.
T18609	27410-27415	DT	denotes	These
T18610	27416-27419	NN	denotes	QTL
T18611	27420-27423	VBP	denotes	are
T18612	27424-27429	JJ	denotes	novel
T18613	27430-27435	IN	denotes	since
T18614	27441-27450	VBP	denotes	represent
T18615	27436-27440	PRP	denotes	they
T18616	27451-27460	NN	denotes	epistasis
T18617	27461-27468	IN	denotes	between
T18618	27469-27471	NN	denotes	hg
T18619	27472-27475	CC	denotes	and
T18620	27476-27479	DT	denotes	the
T18621	27489-27493	NN	denotes	gene
T18622	27480-27488	NN	denotes	modifier
T18623	27493-27494	.	denotes	.
T18624	27494-27587	sentence	denotes	QTL-hg epistasis implies that Socs2 and the hg modifiers are in the same biological pathway.
T18625	27495-27498	NN	denotes	QTL
T18626	27499-27501	NN	denotes	hg
T18627	27498-27499	HYPH	denotes	-
T18628	27502-27511	NN	denotes	epistasis
T18629	27512-27519	VBZ	denotes	implies
T18630	27520-27524	IN	denotes	that
T18631	27552-27555	VBP	denotes	are
T18632	27525-27530	NN	denotes	Socs2
T18633	27531-27534	CC	denotes	and
T18634	27535-27538	DT	denotes	the
T18635	27542-27551	NNS	denotes	modifiers
T18636	27539-27541	NN	denotes	hg
T18637	27556-27558	IN	denotes	in
T18638	27559-27562	DT	denotes	the
T18639	27579-27586	NN	denotes	pathway
T18640	27563-27567	JJ	denotes	same
T18641	27568-27578	JJ	denotes	biological
T18642	27586-27587	.	denotes	.
T18643	27587-27729	sentence	denotes	Therefore, these QTL are likely due to polymorphism in genes interacting with Gh, responsive to Gh or which in some way modulate Gh function.
T18644	27588-27597	RB	denotes	Therefore
T18645	27609-27612	VBP	denotes	are
T18646	27597-27599	,	denotes	,
T18647	27599-27604	DT	denotes	these
T18648	27605-27608	NN	denotes	QTL
T18649	27613-27619	RB	denotes	likely
T18650	27620-27623	IN	denotes	due
T18651	27624-27626	IN	denotes	to
T18652	27627-27639	NN	denotes	polymorphism
T18653	27640-27642	IN	denotes	in
T18654	27643-27648	NNS	denotes	genes
T18655	27649-27660	VBG	denotes	interacting
T18656	27661-27665	IN	denotes	with
T18657	27666-27668	NN	denotes	Gh
T18658	27668-27670	,	denotes	,
T18659	27670-27680	JJ	denotes	responsive
T18660	27681-27683	IN	denotes	to
T18661	27684-27686	NN	denotes	Gh
T18662	27687-27689	CC	denotes	or
T18663	27690-27695	WDT	denotes	which
T18664	27708-27716	VBP	denotes	modulate
T18665	27696-27698	IN	denotes	in
T18666	27699-27703	DT	denotes	some
T18667	27704-27707	NN	denotes	way
T18668	27717-27719	NN	denotes	Gh
T18669	27720-27728	NN	denotes	function
T18670	27728-27729	.	denotes	.
T18671	27729-27831	sentence	denotes	This information will significantly aid QTL cloning by providing another filter to screen candidates.
T18672	27730-27734	DT	denotes	This
T18673	27735-27746	NN	denotes	information
T18674	27766-27769	VB	denotes	aid
T18675	27747-27751	MD	denotes	will
T18676	27752-27765	RB	denotes	significantly
T18677	27770-27773	NN	denotes	QTL
T18678	27774-27781	NN	denotes	cloning
T18679	27782-27784	IN	denotes	by
T18680	27785-27794	VBG	denotes	providing
T18681	27795-27802	DT	denotes	another
T18682	27803-27809	NN	denotes	filter
T18683	27810-27812	TO	denotes	to
T18684	27813-27819	VB	denotes	screen
T18685	27820-27830	NNS	denotes	candidates
T18686	27830-27831	.	denotes	.
T18687	27831-28002	sentence	denotes	Cloning these QTL has major implications to improve our understanding of Gh and its regulation of growth and adiposity and in the administration of human Gh therapeutics.
T18688	27832-27839	VBG	denotes	Cloning
T18689	27846-27849	NN	denotes	QTL
T18690	27840-27845	DT	denotes	these
T18691	27850-27853	VBZ	denotes	has
T18692	27854-27859	JJ	denotes	major
T18693	27860-27872	NNS	denotes	implications
T18694	27873-27875	TO	denotes	to
T18695	27876-27883	VB	denotes	improve
T18696	27884-27887	PRP$	denotes	our
T18697	27888-27901	NN	denotes	understanding
T18698	27902-27904	IN	denotes	of
T18699	27905-27907	NN	denotes	Gh
T18700	27908-27911	CC	denotes	and
T18701	27912-27915	PRP$	denotes	its
T18702	27916-27926	NN	denotes	regulation
T18703	27927-27929	IN	denotes	of
T18704	27930-27936	NN	denotes	growth
T18705	27937-27940	CC	denotes	and
T18706	27941-27950	NN	denotes	adiposity
T18707	27951-27954	CC	denotes	and
T18708	27955-27957	IN	denotes	in
T18709	27958-27961	DT	denotes	the
T18710	27962-27976	NN	denotes	administration
T18711	27977-27979	IN	denotes	of
T18712	27980-27985	JJ	denotes	human
T18713	27986-27988	NN	denotes	Gh
T18714	27989-28001	NNS	denotes	therapeutics
T18715	28001-28002	.	denotes	.
T18716	28002-28056	sentence	denotes	HG1 mice displayed differences only in growth traits.
T18717	28003-28006	NN	denotes	HG1
T18718	28007-28011	NNS	denotes	mice
T18719	28012-28021	VBD	denotes	displayed
T18720	28022-28033	NNS	denotes	differences
T18721	28034-28038	RB	denotes	only
T18722	28039-28041	IN	denotes	in
T18723	28042-28048	NN	denotes	growth
T18724	28049-28055	NNS	denotes	traits
T18725	28055-28056	.	denotes	.
T18726	28056-28295	sentence	denotes	Originally, Q1Ucd1 had small effects and these results illustrate the power of congenic strain analysis to isolate small effect QTL, although it is likely this QTL represents the lower boundary of detection using only 20–30 congenic mice.
T18727	28057-28067	RB	denotes	Originally
T18728	28076-28079	VBD	denotes	had
T18729	28067-28069	,	denotes	,
T18730	28069-28075	NN	denotes	Q1Ucd1
T18731	28080-28085	JJ	denotes	small
T18732	28086-28093	NNS	denotes	effects
T18733	28094-28097	CC	denotes	and
T18734	28098-28103	DT	denotes	these
T18735	28104-28111	NNS	denotes	results
T18736	28112-28122	VBP	denotes	illustrate
T18737	28123-28126	DT	denotes	the
T18738	28127-28132	NN	denotes	power
T18739	28133-28135	IN	denotes	of
T18740	28136-28144	JJ	denotes	congenic
T18741	28145-28151	NN	denotes	strain
T18742	28152-28160	NN	denotes	analysis
T18743	28161-28163	TO	denotes	to
T18744	28164-28171	VB	denotes	isolate
T18745	28172-28177	JJ	denotes	small
T18746	28178-28184	NN	denotes	effect
T18747	28185-28188	NN	denotes	QTL
T18748	28188-28190	,	denotes	,
T18749	28190-28198	IN	denotes	although
T18750	28202-28204	VBZ	denotes	is
T18751	28199-28201	PRP	denotes	it
T18752	28205-28211	JJ	denotes	likely
T18753	28212-28216	DT	denotes	this
T18754	28217-28220	NN	denotes	QTL
T18755	28221-28231	VBZ	denotes	represents
T18756	28232-28235	DT	denotes	the
T18757	28242-28250	NN	denotes	boundary
T18758	28236-28241	JJR	denotes	lower
T18759	28251-28253	IN	denotes	of
T18760	28254-28263	NN	denotes	detection
T18761	28264-28269	VBG	denotes	using
T18762	28270-28274	RB	denotes	only
T18763	28278-28280	CD	denotes	30
T18764	28275-28277	CD	denotes	20
T18765	28277-28278	SYM	denotes	–
T18766	28290-28294	NNS	denotes	mice
T18767	28281-28289	JJ	denotes	congenic
T18768	28294-28295	.	denotes	.
T18769	28295-28438	sentence	denotes	The most notable candidate genes located within the HG1 interval are the signal transducer and activator of transcription 1 (Stat1) and Stat4.
T18770	28296-28299	DT	denotes	The
T18771	28323-28328	NNS	denotes	genes
T18772	28300-28304	RBS	denotes	most
T18773	28305-28312	JJ	denotes	notable
T18774	28313-28322	NN	denotes	candidate
T18775	28361-28364	VBP	denotes	are
T18776	28329-28336	VBN	denotes	located
T18777	28337-28343	IN	denotes	within
T18778	28344-28347	DT	denotes	the
T18779	28352-28360	NN	denotes	interval
T18780	28348-28351	NN	denotes	HG1
T18781	28365-28368	DT	denotes	the
T18782	28376-28386	NN	denotes	transducer
T18783	28369-28375	NN	denotes	signal
T18784	28387-28390	CC	denotes	and
T18785	28391-28400	NN	denotes	activator
T18786	28401-28403	IN	denotes	of
T18787	28404-28417	NN	denotes	transcription
T18788	28418-28419	CD	denotes	1
T18789	28420-28421	-LRB-	denotes	(
T18790	28421-28426	NN	denotes	Stat1
T18791	28426-28427	-RRB-	denotes	)
T18792	28428-28431	CC	denotes	and
T18793	28432-28437	NN	denotes	Stat4
T18794	28437-28438	.	denotes	.
T18795	28438-28531	sentence	denotes	Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9.
T18796	28439-28442	CD	denotes	Two
T18797	28460-28463	VBD	denotes	had
T18798	28443-28445	IN	denotes	of
T18799	28446-28449	DT	denotes	the
T18800	28450-28459	NNS	denotes	congenics
T18801	28464-28469	JJ	denotes	major
T18802	28470-28481	NNS	denotes	alterations
T18803	28482-28484	IN	denotes	in
T18804	28485-28488	DT	denotes	the
T18805	28489-28499	NN	denotes	deposition
T18806	28500-28502	IN	denotes	of
T18807	28503-28510	NN	denotes	adipose
T18808	28511-28517	NN	denotes	tissue
T18809	28517-28519	,	denotes	,
T18810	28519-28522	NN	denotes	HG8
T18811	28523-28526	CC	denotes	and
T18812	28527-28530	NN	denotes	HG9
T18813	28530-28531	.	denotes	.
T18814	28531-28571	sentence	denotes	The HG8 donor region promotes leanness.
T18815	28532-28535	DT	denotes	The
T18816	28546-28552	NN	denotes	region
T18817	28536-28539	NN	denotes	HG8
T18818	28540-28545	NN	denotes	donor
T18819	28553-28561	VBZ	denotes	promotes
T18820	28562-28570	NN	denotes	leanness
T18821	28570-28571	.	denotes	.
T18822	28571-28629	sentence	denotes	Congenic females displayed a reduction of over 25% in AI.
T18823	28572-28580	JJ	denotes	Congenic
T18824	28581-28588	NNS	denotes	females
T18825	28589-28598	VBD	denotes	displayed
T18826	28599-28600	DT	denotes	a
T18827	28601-28610	NN	denotes	reduction
T18828	28611-28613	IN	denotes	of
T18829	28614-28618	IN	denotes	over
T18830	28619-28621	CD	denotes	25
T18831	28621-28622	NN	denotes	%
T18832	28623-28625	IN	denotes	in
T18833	28626-28628	NN	denotes	AI
T18834	28628-28629	.	denotes	.
T18835	28629-28682	sentence	denotes	In contrast, the HG9 strain is an obese mouse model.
T18836	28630-28632	IN	denotes	In
T18837	28658-28660	VBZ	denotes	is
T18838	28633-28641	NN	denotes	contrast
T18839	28641-28643	,	denotes	,
T18840	28643-28646	DT	denotes	the
T18841	28651-28657	NN	denotes	strain
T18842	28647-28650	NN	denotes	HG9
T18843	28661-28663	DT	denotes	an
T18844	28676-28681	NN	denotes	model
T18845	28664-28669	JJ	denotes	obese
T18846	28670-28675	NN	denotes	mouse
T18847	28681-28682	.	denotes	.
T18848	28682-28725	sentence	denotes	The strain is quite novel for two reasons.
T18849	28683-28686	DT	denotes	The
T18850	28687-28693	NN	denotes	strain
T18851	28694-28696	VBZ	denotes	is
T18852	28697-28702	RB	denotes	quite
T18853	28703-28708	JJ	denotes	novel
T18854	28709-28712	IN	denotes	for
T18855	28713-28716	CD	denotes	two
T18856	28717-28724	NNS	denotes	reasons
T18857	28724-28725	.	denotes	.
T18858	28725-28816	sentence	denotes	First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males.
T18859	28726-28731	RB	denotes	First
T18860	28762-28765	VBD	denotes	was
T18861	28731-28733	,	denotes	,
T18862	28733-28736	DT	denotes	the
T18863	28744-28748	NN	denotes	size
T18864	28737-28743	NN	denotes	effect
T18865	28749-28751	VBZ	denotes	is
T18866	28752-28757	JJ	denotes	large
T18867	28757-28758	:	denotes	;
T18868	28759-28761	NN	denotes	AI
T18869	28766-28768	CD	denotes	57
T18870	28768-28769	NN	denotes	%
T18871	28770-28776	JJR	denotes	higher
T18872	28777-28779	IN	denotes	in
T18873	28780-28783	NN	denotes	HG9
T18874	28784-28791	NNS	denotes	females
T18875	28792-28795	CC	denotes	and
T18876	28796-28798	CD	denotes	30
T18877	28798-28799	NN	denotes	%
T18878	28800-28806	JJR	denotes	higher
T18879	28807-28809	IN	denotes	in
T18880	28810-28815	NNS	denotes	males
T18881	28815-28816	.	denotes	.
T18882	28816-28868	sentence	denotes	Secondly, it is dependent on hg for its expression.
T18883	28817-28825	RB	denotes	Secondly
T18884	28830-28832	VBZ	denotes	is
T18885	28825-28827	,	denotes	,
T18886	28827-28829	PRP	denotes	it
T18887	28833-28842	JJ	denotes	dependent
T18888	28843-28845	IN	denotes	on
T18889	28846-28848	NN	denotes	hg
T18890	28849-28852	IN	denotes	for
T18891	28853-28856	PRP$	denotes	its
T18892	28857-28867	NN	denotes	expression
T18893	28867-28868	.	denotes	.
T18894	28868-29056	sentence	denotes	The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh.
T18895	28869-28872	DT	denotes	The
T18896	28877-28883	NN	denotes	strain
T18897	28873-28876	NN	denotes	HG9
T18898	28884-28894	VBZ	denotes	represents
T18899	28895-28896	DT	denotes	a
T18900	28931-28936	NN	denotes	model
T18901	28897-28902	JJ	denotes	major
T18902	28903-28912	NN	denotes	epistasis
T18903	28913-28918	VBN	denotes	based
T18904	28912-28913	HYPH	denotes	-
T18905	28919-28924	JJ	denotes	obese
T18906	28925-28930	NN	denotes	mouse
T18907	28937-28940	CC	denotes	and
T18908	28941-28949	VBZ	denotes	promises
T18909	28950-28952	TO	denotes	to
T18910	28953-28956	VB	denotes	aid
T18911	28957-28959	IN	denotes	in
T18912	28960-28963	DT	denotes	the
T18913	28964-28977	NN	denotes	understanding
T18914	28978-28980	IN	denotes	of
T18915	28981-28988	NN	denotes	obesity
T18916	28989-28992	CC	denotes	and
T18917	28993-29005	RB	denotes	specifically
T18918	29010-29020	NN	denotes	modulation
T18919	29006-29009	DT	denotes	the
T18920	29021-29023	IN	denotes	of
T18921	29024-29031	NN	denotes	adipose
T18922	29032-29038	NN	denotes	tissue
T18923	29039-29049	NN	denotes	deposition
T18924	29050-29052	IN	denotes	by
T18925	29053-29055	NN	denotes	Gh
T18926	29055-29056	.	denotes	.
T18927	29056-29312	sentence	denotes	Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.
T18928	29057-29064	NNS	denotes	Studies
T18929	29065-29068	VBP	denotes	are
T18930	29069-29078	RB	denotes	currently
T18931	29079-29087	JJ	denotes	underway
T18932	29088-29090	TO	denotes	to
T18933	29091-29099	VB	denotes	identify
T18934	29100-29103	DT	denotes	the
T18935	29114-29122	NN	denotes	mutation
T18936	29104-29113	JJ	denotes	causative
T18937	29123-29126	CC	denotes	and
T18938	29127-29129	TO	denotes	to
T18939	29130-29142	VB	denotes	characterize
T18940	29143-29146	DT	denotes	the
T18941	29147-29154	NNS	denotes	effects
T18942	29155-29157	IN	denotes	of
T18943	29158-29161	NN	denotes	age
T18944	29162-29165	CC	denotes	and
T18945	29166-29170	NN	denotes	diet
T18946	29171-29173	IN	denotes	on
T18947	29174-29181	NN	denotes	obesity
T18948	29182-29184	IN	denotes	in
T18949	29185-29189	DT	denotes	this
T18950	29190-29196	NN	denotes	strain
T18951	29197-29199	RB	denotes	as
T18952	29205-29207	IN	denotes	as
T18953	29200-29204	RB	denotes	well
T18954	29208-29215	NN	denotes	testing
T18955	29216-29219	IN	denotes	for
T18956	29220-29225	JJ	denotes	other
T18957	29240-29252	NNS	denotes	consequences
T18958	29226-29239	JJ	denotes	physiological
T18959	29253-29257	JJ	denotes	such
T18960	29258-29260	IN	denotes	as
T18961	29261-29272	NNS	denotes	alterations
T18962	29273-29275	IN	denotes	in
T18963	29276-29280	NN	denotes	food
T18964	29281-29287	NN	denotes	intake
T18965	29288-29291	CC	denotes	and
T18966	29292-29299	NN	denotes	insulin
T18967	29300-29311	NN	denotes	sensitivity
T18968	29311-29312	.	denotes	.
T18969	29312-29379	sentence	denotes	The HG11 strain is of particular interest for a number of reasons.
T18970	29313-29316	DT	denotes	The
T18971	29322-29328	NN	denotes	strain
T18972	29317-29321	NN	denotes	HG11
T18973	29329-29331	VBZ	denotes	is
T18974	29332-29334	IN	denotes	of
T18975	29335-29345	JJ	denotes	particular
T18976	29346-29354	NN	denotes	interest
T18977	29355-29358	IN	denotes	for
T18978	29359-29360	DT	denotes	a
T18979	29361-29367	NN	denotes	number
T18980	29368-29370	IN	denotes	of
T18981	29371-29378	NNS	denotes	reasons
T18982	29378-29379	.	denotes	.
T18983	29379-29481	sentence	denotes	First, HG11 congenic mice demonstrated significant strain by sex interactions for a number of traits.
T18984	29380-29385	RB	denotes	First
T18985	29406-29418	VBD	denotes	demonstrated
T18986	29385-29387	,	denotes	,
T18987	29387-29391	NN	denotes	HG11
T18988	29392-29400	JJ	denotes	congenic
T18989	29401-29405	NNS	denotes	mice
T18990	29419-29430	JJ	denotes	significant
T18991	29445-29457	NNS	denotes	interactions
T18992	29431-29437	NN	denotes	strain
T18993	29438-29440	IN	denotes	by
T18994	29441-29444	NN	denotes	sex
T18995	29458-29461	IN	denotes	for
T18996	29462-29463	DT	denotes	a
T18997	29464-29470	NN	denotes	number
T18998	29471-29473	IN	denotes	of
T18999	29474-29480	NNS	denotes	traits
T19000	29480-29481	.	denotes	.
T19001	29481-29574	sentence	denotes	Males were generally larger, faster growing and longer and the converse was seen in females.
T19002	29482-29487	NNS	denotes	Males
T19003	29488-29492	VBD	denotes	were
T19004	29493-29502	RB	denotes	generally
T19005	29503-29509	JJR	denotes	larger
T19006	29509-29511	,	denotes	,
T19007	29511-29517	JJR	denotes	faster
T19008	29518-29525	VBG	denotes	growing
T19009	29526-29529	CC	denotes	and
T19010	29530-29536	JJR	denotes	longer
T19011	29537-29540	CC	denotes	and
T19012	29541-29544	DT	denotes	the
T19013	29545-29553	NN	denotes	converse
T19014	29558-29562	VBN	denotes	seen
T19015	29554-29557	VBD	denotes	was
T19016	29563-29565	IN	denotes	in
T19017	29566-29573	NNS	denotes	females
T19018	29573-29574	.	denotes	.
T19019	29574-29736	sentence	denotes	The confounding effects of sex are likely the reason for the discrepancies between the congenic and genome scan results, where both sexes were analyzed together.
T19020	29575-29578	DT	denotes	The
T19021	29591-29598	NNS	denotes	effects
T19022	29579-29590	VBG	denotes	confounding
T19023	29606-29609	VBP	denotes	are
T19024	29599-29601	IN	denotes	of
T19025	29602-29605	NN	denotes	sex
T19026	29610-29616	RB	denotes	likely
T19027	29617-29620	DT	denotes	the
T19028	29621-29627	NN	denotes	reason
T19029	29628-29631	IN	denotes	for
T19030	29632-29635	DT	denotes	the
T19031	29636-29649	NNS	denotes	discrepancies
T19032	29650-29657	IN	denotes	between
T19033	29658-29661	DT	denotes	the
T19034	29687-29694	NNS	denotes	results
T19035	29662-29670	JJ	denotes	congenic
T19036	29675-29681	NN	denotes	genome
T19037	29671-29674	CC	denotes	and
T19038	29682-29686	NN	denotes	scan
T19039	29694-29696	,	denotes	,
T19040	29696-29701	WRB	denotes	where
T19041	29718-29726	VBN	denotes	analyzed
T19042	29702-29706	DT	denotes	both
T19043	29707-29712	NNS	denotes	sexes
T19044	29713-29717	VBD	denotes	were
T19045	29727-29735	RB	denotes	together
T19046	29735-29736	.	denotes	.
T19047	29736-29907	sentence	denotes	Secondly, Carp2 was found to interact with hg and MMU11 is saturated with genes involved in the central Gh intracellular signaling pathway, such as Gh, Stat5b and Stat5a.
T19048	29737-29745	RB	denotes	Secondly
T19049	29757-29762	VBN	denotes	found
T19050	29745-29747	,	denotes	,
T19051	29747-29752	NN	denotes	Carp2
T19052	29753-29756	VBD	denotes	was
T19053	29763-29765	TO	denotes	to
T19054	29766-29774	VB	denotes	interact
T19055	29775-29779	IN	denotes	with
T19056	29780-29782	NN	denotes	hg
T19057	29783-29786	CC	denotes	and
T19058	29787-29792	NN	denotes	MMU11
T19059	29796-29805	VBN	denotes	saturated
T19060	29793-29795	VBZ	denotes	is
T19061	29806-29810	IN	denotes	with
T19062	29811-29816	NNS	denotes	genes
T19063	29817-29825	VBN	denotes	involved
T19064	29826-29828	IN	denotes	in
T19065	29829-29832	DT	denotes	the
T19066	29868-29875	NN	denotes	pathway
T19067	29833-29840	JJ	denotes	central
T19068	29841-29843	NN	denotes	Gh
T19069	29844-29857	JJ	denotes	intracellular
T19070	29858-29867	NN	denotes	signaling
T19071	29875-29877	,	denotes	,
T19072	29877-29881	JJ	denotes	such
T19073	29882-29884	IN	denotes	as
T19074	29885-29887	NN	denotes	Gh
T19075	29887-29889	,	denotes	,
T19076	29889-29895	NN	denotes	Stat5b
T19077	29896-29899	CC	denotes	and
T19078	29900-29906	NN	denotes	Stat5a
T19079	29906-29907	.	denotes	.
T19080	29907-30033	sentence	denotes	Thirdly, MMU11 growth QTL overlapping HG11 have been identified in a number of crosses using different mouse strains [37-41].
T19081	29908-29915	RB	denotes	Thirdly
T19082	29961-29971	VBN	denotes	identified
T19083	29915-29917	,	denotes	,
T19084	29917-29922	NN	denotes	MMU11
T19085	29930-29933	NN	denotes	QTL
T19086	29923-29929	NN	denotes	growth
T19087	29934-29945	VBG	denotes	overlapping
T19088	29946-29950	NN	denotes	HG11
T19089	29951-29955	VBP	denotes	have
T19090	29956-29960	VBN	denotes	been
T19091	29972-29974	IN	denotes	in
T19092	29975-29976	DT	denotes	a
T19093	29977-29983	NN	denotes	number
T19094	29984-29986	IN	denotes	of
T19095	29987-29994	NNS	denotes	crosses
T19096	29995-30000	VBG	denotes	using
T19097	30001-30010	JJ	denotes	different
T19098	30017-30024	NNS	denotes	strains
T19099	30011-30016	NN	denotes	mouse
T19100	30025-30026	-LRB-	denotes	[
T19101	30026-30028	CD	denotes	37
T19102	30028-30029	SYM	denotes	-
T19103	30029-30031	CD	denotes	41
T19104	30031-30032	-RRB-	denotes	]
T19105	30032-30033	.	denotes	.
T19106	30033-30270	sentence	denotes	Given the well documented sexually dimorphic nature of Gh secretion and Gh induced gene expression [42,43], it is probable that the underlying mutation in the HG11 congenic may reside in a gene enhancing Gh induced sex-specific effects.
T19107	30034-30039	VBN	denotes	Given
T19108	30145-30147	VBZ	denotes	is
T19109	30040-30043	DT	denotes	the
T19110	30079-30085	NN	denotes	nature
T19111	30044-30048	RB	denotes	well
T19112	30049-30059	VBN	denotes	documented
T19113	30060-30068	RB	denotes	sexually
T19114	30069-30078	JJ	denotes	dimorphic
T19115	30086-30088	IN	denotes	of
T19116	30089-30091	NN	denotes	Gh
T19117	30092-30101	NN	denotes	secretion
T19118	30102-30105	CC	denotes	and
T19119	30106-30108	NN	denotes	Gh
T19120	30109-30116	VBN	denotes	induced
T19121	30122-30132	NN	denotes	expression
T19122	30117-30121	NN	denotes	gene
T19123	30133-30134	-LRB-	denotes	[
T19124	30137-30139	CD	denotes	43
T19125	30134-30136	CD	denotes	42
T19126	30136-30137	,	denotes	,
T19127	30139-30140	-RRB-	denotes	]
T19128	30140-30142	,	denotes	,
T19129	30142-30144	PRP	denotes	it
T19130	30148-30156	JJ	denotes	probable
T19131	30157-30161	IN	denotes	that
T19132	30211-30217	VB	denotes	reside
T19133	30162-30165	DT	denotes	the
T19134	30177-30185	NN	denotes	mutation
T19135	30166-30176	VBG	denotes	underlying
T19136	30186-30188	IN	denotes	in
T19137	30189-30192	DT	denotes	the
T19138	30193-30197	NN	denotes	HG11
T19139	30198-30206	JJ	denotes	congenic
T19140	30207-30210	MD	denotes	may
T19141	30218-30220	IN	denotes	in
T19142	30221-30222	DT	denotes	a
T19143	30223-30227	NN	denotes	gene
T19144	30228-30237	VBG	denotes	enhancing
T19145	30238-30240	NN	denotes	Gh
T19146	30241-30248	VBN	denotes	induced
T19147	30262-30269	NNS	denotes	effects
T19148	30249-30252	NN	denotes	sex
T19149	30253-30261	JJ	denotes	specific
T19150	30252-30253	HYPH	denotes	-
T19151	30269-30270	.	denotes	.
T19152	30270-30337	sentence	denotes	The structural Gh gene itself and Stat5b are excellent candidates.
T19153	30271-30274	DT	denotes	The
T19154	30289-30293	NN	denotes	gene
T19155	30275-30285	JJ	denotes	structural
T19156	30286-30288	NN	denotes	Gh
T19157	30312-30315	VBP	denotes	are
T19158	30294-30300	PRP	denotes	itself
T19159	30301-30304	CC	denotes	and
T19160	30305-30311	NN	denotes	Stat5b
T19161	30316-30325	JJ	denotes	excellent
T19162	30326-30336	NNS	denotes	candidates
T19163	30336-30337	.	denotes	.
T19164	30337-30493	sentence	denotes	The potential role of Gh would include polymorphism that alters protein function in the absence of Socs2 or that causes transcriptional deregulation of Gh.
T19165	30338-30341	DT	denotes	The
T19166	30352-30356	NN	denotes	role
T19167	30342-30351	JJ	denotes	potential
T19168	30369-30376	VB	denotes	include
T19169	30357-30359	IN	denotes	of
T19170	30360-30362	NN	denotes	Gh
T19171	30363-30368	MD	denotes	would
T19172	30377-30389	NN	denotes	polymorphism
T19173	30390-30394	WDT	denotes	that
T19174	30395-30401	VBZ	denotes	alters
T19175	30402-30409	NN	denotes	protein
T19176	30410-30418	NN	denotes	function
T19177	30419-30421	IN	denotes	in
T19178	30422-30425	DT	denotes	the
T19179	30426-30433	NN	denotes	absence
T19180	30434-30436	IN	denotes	of
T19181	30437-30442	NN	denotes	Socs2
T19182	30443-30445	CC	denotes	or
T19183	30446-30450	DT	denotes	that
T19184	30451-30457	VBZ	denotes	causes
T19185	30458-30473	JJ	denotes	transcriptional
T19186	30474-30486	NN	denotes	deregulation
T19187	30487-30489	IN	denotes	of
T19188	30490-30492	NN	denotes	Gh
T19189	30492-30493	.	denotes	.
T19190	30493-30704	sentence	denotes	Additionally, functional variation in Stat5b may explain the sex-specific phenotypes in HG11 mice since it is the primary transcription factor responsible for Gh induced sex-specific liver gene expression [44].
T19191	30494-30506	RB	denotes	Additionally
T19192	30543-30550	VB	denotes	explain
T19193	30506-30508	,	denotes	,
T19194	30508-30518	JJ	denotes	functional
T19195	30519-30528	NN	denotes	variation
T19196	30529-30531	IN	denotes	in
T19197	30532-30538	NN	denotes	Stat5b
T19198	30539-30542	MD	denotes	may
T19199	30551-30554	DT	denotes	the
T19200	30568-30578	NNS	denotes	phenotypes
T19201	30555-30558	NN	denotes	sex
T19202	30559-30567	JJ	denotes	specific
T19203	30558-30559	HYPH	denotes	-
T19204	30579-30581	IN	denotes	in
T19205	30582-30586	NN	denotes	HG11
T19206	30587-30591	NNS	denotes	mice
T19207	30592-30597	IN	denotes	since
T19208	30601-30603	VBZ	denotes	is
T19209	30598-30600	PRP	denotes	it
T19210	30604-30607	DT	denotes	the
T19211	30630-30636	NN	denotes	factor
T19212	30608-30615	JJ	denotes	primary
T19213	30616-30629	NN	denotes	transcription
T19214	30637-30648	JJ	denotes	responsible
T19215	30649-30652	IN	denotes	for
T19216	30653-30655	NN	denotes	Gh
T19217	30656-30663	VBN	denotes	induced
T19218	30688-30698	NN	denotes	expression
T19219	30664-30667	NN	denotes	sex
T19220	30668-30676	JJ	denotes	specific
T19221	30667-30668	HYPH	denotes	-
T19222	30677-30682	NN	denotes	liver
T19223	30683-30687	NN	denotes	gene
T19224	30699-30700	-LRB-	denotes	[
T19225	30700-30702	CD	denotes	44
T19226	30702-30703	-RRB-	denotes	]
T19227	30703-30704	.	denotes	.
T19228	30704-30873	sentence	denotes	Future studies aimed at identifying the HG11 QTG, will certainly include a thorough characterization of Gh and Stat5b sequence and expression patterns in congenic mice.
T19229	30705-30711	JJ	denotes	Future
T19230	30712-30719	NNS	denotes	studies
T19231	30770-30777	VB	denotes	include
T19232	30720-30725	VBN	denotes	aimed
T19233	30726-30728	IN	denotes	at
T19234	30729-30740	VBG	denotes	identifying
T19235	30741-30744	DT	denotes	the
T19236	30750-30753	NN	denotes	QTG
T19237	30745-30749	NN	denotes	HG11
T19238	30753-30755	,	denotes	,
T19239	30755-30759	MD	denotes	will
T19240	30760-30769	RB	denotes	certainly
T19241	30778-30779	DT	denotes	a
T19242	30789-30805	NN	denotes	characterization
T19243	30780-30788	JJ	denotes	thorough
T19244	30806-30808	IN	denotes	of
T19245	30809-30811	NN	denotes	Gh
T19246	30847-30855	NNS	denotes	patterns
T19247	30812-30815	CC	denotes	and
T19248	30816-30822	NN	denotes	Stat5b
T19249	30823-30831	NN	denotes	sequence
T19250	30832-30835	CC	denotes	and
T19251	30836-30846	NN	denotes	expression
T19252	30856-30858	IN	denotes	in
T19253	30859-30867	JJ	denotes	congenic
T19254	30868-30872	NNS	denotes	mice
T19255	30872-30873	.	denotes	.
T19256	30873-30989	sentence	denotes	The hg modifier QTL located within the HG17 strain had large effects on growth, body length and carcass components.
T19257	30874-30877	DT	denotes	The
T19258	30890-30893	NN	denotes	QTL
T19259	30878-30880	NN	denotes	hg
T19260	30881-30889	NN	denotes	modifier
T19261	30925-30928	VBD	denotes	had
T19262	30894-30901	VBN	denotes	located
T19263	30902-30908	IN	denotes	within
T19264	30909-30912	DT	denotes	the
T19265	30918-30924	NN	denotes	strain
T19266	30913-30917	NN	denotes	HG17
T19267	30929-30934	JJ	denotes	large
T19268	30935-30942	NNS	denotes	effects
T19269	30943-30945	IN	denotes	on
T19270	30946-30952	NN	denotes	growth
T19271	30952-30954	,	denotes	,
T19272	30954-30958	NN	denotes	body
T19273	30959-30965	NN	denotes	length
T19274	30966-30969	CC	denotes	and
T19275	30970-30977	NN	denotes	carcass
T19276	30978-30988	NNS	denotes	components
T19277	30988-30989	.	denotes	.
T19278	30989-31058	sentence	denotes	The most intriguing candidate gene located in the congenic is Sstr5.
T19279	30990-30993	DT	denotes	The
T19280	31020-31024	NN	denotes	gene
T19281	30994-30998	RBS	denotes	most
T19282	30999-31009	JJ	denotes	intriguing
T19283	31010-31019	NN	denotes	candidate
T19284	31049-31051	VBZ	denotes	is
T19285	31025-31032	VBN	denotes	located
T19286	31033-31035	IN	denotes	in
T19287	31036-31039	DT	denotes	the
T19288	31040-31048	JJ	denotes	congenic
T19289	31052-31057	NN	denotes	Sstr5
T19290	31057-31058	.	denotes	.
T19291	31058-31171	sentence	denotes	Somatostatin is a potent inhibitor of Gh and Sstr5 is one of five receptors which mediate these effects [45,46].
T19292	31059-31071	NN	denotes	Somatostatin
T19293	31072-31074	VBZ	denotes	is
T19294	31075-31076	DT	denotes	a
T19295	31084-31093	NN	denotes	inhibitor
T19296	31077-31083	JJ	denotes	potent
T19297	31094-31096	IN	denotes	of
T19298	31097-31099	NN	denotes	Gh
T19299	31100-31103	CC	denotes	and
T19300	31104-31109	NN	denotes	Sstr5
T19301	31110-31112	VBZ	denotes	is
T19302	31113-31116	CD	denotes	one
T19303	31117-31119	IN	denotes	of
T19304	31120-31124	CD	denotes	five
T19305	31125-31134	NNS	denotes	receptors
T19306	31135-31140	WDT	denotes	which
T19307	31141-31148	VBP	denotes	mediate
T19308	31149-31154	DT	denotes	these
T19309	31155-31162	NNS	denotes	effects
T19310	31163-31164	-LRB-	denotes	[
T19311	31167-31169	CD	denotes	46
T19312	31164-31166	CD	denotes	45
T19313	31166-31167	,	denotes	,
T19314	31169-31170	-RRB-	denotes	]
T19315	31170-31171	.	denotes	.
T19316	31171-31309	sentence	denotes	Ubiquitous and pancreatic beta cell specific knockout of Sstr5 leads to alterations in insulin secretion and glucose homeostasis [47,48].
T19317	31172-31182	JJ	denotes	Ubiquitous
T19318	31217-31225	NN	denotes	knockout
T19319	31183-31186	CC	denotes	and
T19320	31187-31197	JJ	denotes	pancreatic
T19321	31203-31207	NN	denotes	cell
T19322	31198-31202	NN	denotes	beta
T19323	31208-31216	JJ	denotes	specific
T19324	31235-31240	VBZ	denotes	leads
T19325	31226-31228	IN	denotes	of
T19326	31229-31234	NN	denotes	Sstr5
T19327	31241-31243	IN	denotes	to
T19328	31244-31255	NNS	denotes	alterations
T19329	31256-31258	IN	denotes	in
T19330	31259-31266	NN	denotes	insulin
T19331	31267-31276	NN	denotes	secretion
T19332	31277-31280	CC	denotes	and
T19333	31281-31288	NN	denotes	glucose
T19334	31289-31300	NN	denotes	homeostasis
T19335	31301-31302	-LRB-	denotes	[
T19336	31305-31307	CD	denotes	48
T19337	31302-31304	CD	denotes	47
T19338	31304-31305	,	denotes	,
T19339	31307-31308	-RRB-	denotes	]
T19340	31308-31309	.	denotes	.
T19341	31309-31431	sentence	denotes	We sequenced candidate hg modifier genes to complement the characterization of the speed congenics on MMU2, 9, 11 and 17.
T19342	31310-31312	PRP	denotes	We
T19343	31313-31322	VBD	denotes	sequenced
T19344	31323-31332	NN	denotes	candidate
T19345	31345-31350	NNS	denotes	genes
T19346	31333-31335	NN	denotes	hg
T19347	31336-31344	NN	denotes	modifier
T19348	31351-31353	TO	denotes	to
T19349	31354-31364	VB	denotes	complement
T19350	31365-31368	DT	denotes	the
T19351	31369-31385	NN	denotes	characterization
T19352	31386-31388	IN	denotes	of
T19353	31389-31392	DT	denotes	the
T19354	31399-31408	NNS	denotes	congenics
T19355	31393-31398	NN	denotes	speed
T19356	31409-31411	IN	denotes	on
T19357	31412-31415	NN	denotes	MMU
T19358	31415-31416	CD	denotes	2
T19359	31416-31418	,	denotes	,
T19360	31418-31419	CD	denotes	9
T19361	31419-31421	,	denotes	,
T19362	31421-31423	CD	denotes	11
T19363	31424-31427	CC	denotes	and
T19364	31428-31430	CD	denotes	17
T19365	31430-31431	.	denotes	.
T19366	31431-31628	sentence	denotes	A limited number of studies have identified variation within CAST coding sequence; so sequencing candidates gave us the opportunity to estimate the SNP frequency in coding sequence relative to B6.
T19367	31432-31433	DT	denotes	A
T19368	31442-31448	NN	denotes	number
T19369	31434-31441	JJ	denotes	limited
T19370	31465-31475	VBN	denotes	identified
T19371	31449-31451	IN	denotes	of
T19372	31452-31459	NNS	denotes	studies
T19373	31460-31464	VBP	denotes	have
T19374	31476-31485	NN	denotes	variation
T19375	31486-31492	IN	denotes	within
T19376	31493-31497	NN	denotes	CAST
T19377	31505-31513	NN	denotes	sequence
T19378	31498-31504	NN	denotes	coding
T19379	31513-31514	:	denotes	;
T19380	31515-31517	CC	denotes	so
T19381	31518-31528	VBG	denotes	sequencing
T19382	31529-31539	NNS	denotes	candidates
T19383	31540-31544	VBD	denotes	gave
T19384	31545-31547	PRP	denotes	us
T19385	31548-31551	DT	denotes	the
T19386	31552-31563	NN	denotes	opportunity
T19387	31564-31566	TO	denotes	to
T19388	31567-31575	VB	denotes	estimate
T19389	31576-31579	DT	denotes	the
T19390	31584-31593	NN	denotes	frequency
T19391	31580-31583	NN	denotes	SNP
T19392	31594-31596	IN	denotes	in
T19393	31597-31603	NN	denotes	coding
T19394	31604-31612	NN	denotes	sequence
T19395	31613-31621	JJ	denotes	relative
T19396	31622-31624	IN	denotes	to
T19397	31625-31627	NN	denotes	B6
T19398	31627-31628	.	denotes	.
T19399	31628-31736	sentence	denotes	This information will be vital to future fine mapping studies, which will include gene expression analysis.
T19400	31629-31633	DT	denotes	This
T19401	31634-31645	NN	denotes	information
T19402	31651-31653	VB	denotes	be
T19403	31646-31650	MD	denotes	will
T19404	31654-31659	JJ	denotes	vital
T19405	31660-31662	IN	denotes	to
T19406	31663-31669	JJ	denotes	future
T19407	31683-31690	NNS	denotes	studies
T19408	31670-31674	JJ	denotes	fine
T19409	31675-31682	NN	denotes	mapping
T19410	31690-31692	,	denotes	,
T19411	31692-31697	WDT	denotes	which
T19412	31703-31710	VB	denotes	include
T19413	31698-31702	MD	denotes	will
T19414	31711-31715	NN	denotes	gene
T19415	31716-31726	NN	denotes	expression
T19416	31727-31735	NN	denotes	analysis
T19417	31735-31736	.	denotes	.
T19418	31736-31950	sentence	denotes	The high SNP frequency (0.312%; 295 SNP in 94.492 kbp) in CAST genes may lead to a higher rate of false positives using DNA microarrays or quantitative real-time PCR assays, most of which are based on B6 sequence.
T19419	31737-31740	DT	denotes	The
T19420	31750-31759	NN	denotes	frequency
T19421	31741-31745	JJ	denotes	high
T19422	31746-31749	NN	denotes	SNP
T19423	31810-31814	VB	denotes	lead
T19424	31760-31761	-LRB-	denotes	(
T19425	31773-31776	NN	denotes	SNP
T19426	31761-31766	CD	denotes	0.312
T19427	31766-31767	NN	denotes	%
T19428	31767-31768	:	denotes	;
T19429	31769-31772	CD	denotes	295
T19430	31777-31779	IN	denotes	in
T19431	31780-31786	CD	denotes	94.492
T19432	31787-31790	NN	denotes	kbp
T19433	31790-31791	-RRB-	denotes	)
T19434	31792-31794	IN	denotes	in
T19435	31795-31799	NN	denotes	CAST
T19436	31800-31805	NNS	denotes	genes
T19437	31806-31809	MD	denotes	may
T19438	31815-31817	IN	denotes	to
T19439	31818-31819	DT	denotes	a
T19440	31827-31831	NN	denotes	rate
T19441	31820-31826	JJR	denotes	higher
T19442	31832-31834	IN	denotes	of
T19443	31835-31840	JJ	denotes	false
T19444	31841-31850	NNS	denotes	positives
T19445	31851-31856	VBG	denotes	using
T19446	31857-31860	NN	denotes	DNA
T19447	31861-31872	NNS	denotes	microarrays
T19448	31873-31875	CC	denotes	or
T19449	31876-31888	JJ	denotes	quantitative
T19450	31903-31909	NNS	denotes	assays
T19451	31889-31893	JJ	denotes	real
T19452	31894-31898	NN	denotes	time
T19453	31893-31894	HYPH	denotes	-
T19454	31899-31902	NN	denotes	PCR
T19455	31909-31911	,	denotes	,
T19456	31911-31915	JJS	denotes	most
T19457	31929-31934	VBN	denotes	based
T19458	31916-31918	IN	denotes	of
T19459	31919-31924	WDT	denotes	which
T19460	31925-31928	VBP	denotes	are
T19461	31935-31937	IN	denotes	on
T19462	31938-31940	NN	denotes	B6
T19463	31941-31949	NN	denotes	sequence
T19464	31949-31950	.	denotes	.
T19465	31950-32181	sentence	denotes	Therefore, these sequence data can be used to guide the development of gene expression assays to confirm differential expression for candidates and suggests that genes identified by downstream experiments should also be sequenced.
T19466	31951-31960	RB	denotes	Therefore
T19467	31989-31993	VBN	denotes	used
T19468	31960-31962	,	denotes	,
T19469	31962-31967	DT	denotes	these
T19470	31977-31981	NNS	denotes	data
T19471	31968-31976	NN	denotes	sequence
T19472	31982-31985	MD	denotes	can
T19473	31986-31988	VB	denotes	be
T19474	31994-31996	TO	denotes	to
T19475	31997-32002	VB	denotes	guide
T19476	32003-32006	DT	denotes	the
T19477	32007-32018	NN	denotes	development
T19478	32019-32021	IN	denotes	of
T19479	32022-32026	NN	denotes	gene
T19480	32027-32037	NN	denotes	expression
T19481	32038-32044	NNS	denotes	assays
T19482	32045-32047	TO	denotes	to
T19483	32048-32055	VB	denotes	confirm
T19484	32056-32068	JJ	denotes	differential
T19485	32069-32079	NN	denotes	expression
T19486	32080-32083	IN	denotes	for
T19487	32084-32094	NNS	denotes	candidates
T19488	32095-32098	CC	denotes	and
T19489	32099-32107	VBZ	denotes	suggests
T19490	32108-32112	IN	denotes	that
T19491	32171-32180	VBN	denotes	sequenced
T19492	32113-32118	NNS	denotes	genes
T19493	32119-32129	VBN	denotes	identified
T19494	32130-32132	IN	denotes	by
T19495	32133-32143	JJ	denotes	downstream
T19496	32144-32155	NNS	denotes	experiments
T19497	32156-32162	MD	denotes	should
T19498	32163-32167	RB	denotes	also
T19499	32168-32170	VB	denotes	be
T19500	32180-32181	.	denotes	.
T19501	32181-32308	sentence	denotes	More importantly, sequencing hg modifier candidates allowed us to identify nonsynonomous polymorphism, which may underlie QTL.
T19502	32182-32186	RBR	denotes	More
T19503	32187-32198	RB	denotes	importantly
T19504	32234-32241	VBD	denotes	allowed
T19505	32198-32200	,	denotes	,
T19506	32200-32210	VBG	denotes	sequencing
T19507	32211-32213	NN	denotes	hg
T19508	32214-32222	NN	denotes	modifier
T19509	32223-32233	NNS	denotes	candidates
T19510	32242-32244	PRP	denotes	us
T19511	32248-32256	VB	denotes	identify
T19512	32245-32247	TO	denotes	to
T19513	32257-32270	JJ	denotes	nonsynonomous
T19514	32271-32283	NN	denotes	polymorphism
T19515	32283-32285	,	denotes	,
T19516	32285-32290	WDT	denotes	which
T19517	32295-32303	VB	denotes	underlie
T19518	32291-32294	MD	denotes	may
T19519	32304-32307	NN	denotes	QTL
T19520	32307-32308	.	denotes	.
T19521	32308-32453	sentence	denotes	SIFT and/or PolyPhen predicted alterations in protein function for 15 of the 56 total nsSNP (27%) in nine of the 44 total genes (20%) (Table 7).
T19522	32309-32313	NNP	denotes	SIFT
T19523	32330-32339	VBN	denotes	predicted
T19524	32314-32317	CC	denotes	and
T19525	32317-32318	HYPH	denotes	/
T19526	32318-32320	CC	denotes	or
T19527	32321-32329	NNP	denotes	PolyPhen
T19528	32340-32351	NNS	denotes	alterations
T19529	32352-32354	IN	denotes	in
T19530	32355-32362	NN	denotes	protein
T19531	32363-32371	NN	denotes	function
T19532	32372-32375	IN	denotes	for
T19533	32376-32378	CD	denotes	15
T19534	32379-32381	IN	denotes	of
T19535	32382-32385	DT	denotes	the
T19536	32395-32400	NN	denotes	nsSNP
T19537	32386-32388	CD	denotes	56
T19538	32389-32394	JJ	denotes	total
T19539	32401-32402	-LRB-	denotes	(
T19540	32404-32405	NN	denotes	%
T19541	32402-32404	CD	denotes	27
T19542	32405-32406	-RRB-	denotes	)
T19543	32407-32409	IN	denotes	in
T19544	32410-32414	CD	denotes	nine
T19545	32415-32417	IN	denotes	of
T19546	32418-32421	DT	denotes	the
T19547	32431-32436	NNS	denotes	genes
T19548	32422-32424	CD	denotes	44
T19549	32425-32430	JJ	denotes	total
T19550	32437-32438	-LRB-	denotes	(
T19551	32440-32441	NN	denotes	%
T19552	32438-32440	CD	denotes	20
T19553	32441-32442	-RRB-	denotes	)
T19554	32443-32444	-LRB-	denotes	(
T19555	32444-32449	NN	denotes	Table
T19556	32450-32451	CD	denotes	7
T19557	32451-32452	-RRB-	denotes	)
T19558	32452-32453	.	denotes	.
T19559	32453-32595	sentence	denotes	It has been shown that predicting function based on evolutionary conservation using programs such as SIFT and PolyPhen is very accurate [49].
T19560	32454-32456	PRP	denotes	It
T19561	32466-32471	VBN	denotes	shown
T19562	32457-32460	VBZ	denotes	has
T19563	32461-32465	VBN	denotes	been
T19564	32472-32476	IN	denotes	that
T19565	32573-32575	VBZ	denotes	is
T19566	32477-32487	VBG	denotes	predicting
T19567	32488-32496	NN	denotes	function
T19568	32497-32502	VBN	denotes	based
T19569	32503-32505	IN	denotes	on
T19570	32506-32518	JJ	denotes	evolutionary
T19571	32519-32531	NN	denotes	conservation
T19572	32532-32537	VBG	denotes	using
T19573	32538-32546	NNS	denotes	programs
T19574	32547-32551	JJ	denotes	such
T19575	32552-32554	IN	denotes	as
T19576	32555-32559	NNP	denotes	SIFT
T19577	32560-32563	CC	denotes	and
T19578	32564-32572	NNP	denotes	PolyPhen
T19579	32576-32580	RB	denotes	very
T19580	32581-32589	JJ	denotes	accurate
T19581	32590-32591	-LRB-	denotes	[
T19582	32591-32593	CD	denotes	49
T19583	32593-32594	-RRB-	denotes	]
T19584	32594-32595	.	denotes	.
T19585	32595-32706	sentence	denotes	Four of the nine genes (Ubr1, Ptpns1, Ubce7ip5 and Mmp9; all of which are on MMU2) are of particular interest.
T19586	32596-32600	CD	denotes	Four
T19587	32679-32682	VBP	denotes	are
T19588	32601-32603	IN	denotes	of
T19589	32604-32607	DT	denotes	the
T19590	32613-32618	NNS	denotes	genes
T19591	32608-32612	CD	denotes	nine
T19592	32619-32620	-LRB-	denotes	(
T19593	32620-32624	NN	denotes	Ubr1
T19594	32624-32626	,	denotes	,
T19595	32626-32632	NN	denotes	Ptpns1
T19596	32632-32634	,	denotes	,
T19597	32634-32642	NN	denotes	Ubce7ip5
T19598	32643-32646	CC	denotes	and
T19599	32647-32651	NN	denotes	Mmp9
T19600	32651-32652	:	denotes	;
T19601	32653-32656	DT	denotes	all
T19602	32666-32669	VBP	denotes	are
T19603	32657-32659	IN	denotes	of
T19604	32660-32665	WDT	denotes	which
T19605	32670-32672	IN	denotes	on
T19606	32673-32677	NN	denotes	MMU2
T19607	32677-32678	-RRB-	denotes	)
T19608	32683-32685	IN	denotes	of
T19609	32686-32696	JJ	denotes	particular
T19610	32697-32705	NN	denotes	interest
T19611	32705-32706	.	denotes	.
T19612	32706-32829	sentence	denotes	It has been suggested the Socs2 may rely on ubiquitination dependent proteasomal degradation to inhibit Gh signaling [23].
T19613	32707-32709	PRP	denotes	It
T19614	32719-32728	VBN	denotes	suggested
T19615	32710-32713	VBZ	denotes	has
T19616	32714-32718	VBN	denotes	been
T19617	32729-32732	DT	denotes	the
T19618	32733-32738	NN	denotes	Socs2
T19619	32743-32747	VB	denotes	rely
T19620	32739-32742	MD	denotes	may
T19621	32748-32750	IN	denotes	on
T19622	32751-32765	NN	denotes	ubiquitination
T19623	32766-32775	JJ	denotes	dependent
T19624	32788-32799	NN	denotes	degradation
T19625	32776-32787	JJ	denotes	proteasomal
T19626	32800-32802	TO	denotes	to
T19627	32803-32810	VB	denotes	inhibit
T19628	32811-32813	NN	denotes	Gh
T19629	32814-32823	NN	denotes	signaling
T19630	32824-32825	-LRB-	denotes	[
T19631	32825-32827	CD	denotes	23
T19632	32827-32828	-RRB-	denotes	]
T19633	32828-32829	.	denotes	.
T19634	32829-33003	sentence	denotes	Ubr1 and Ubce7ip5 are both involved in protein ubiquitination and Ubr1 knockout mice show an 20% decrease in body weight partly due to a reduction in adipose tissue [50,51].
T19635	32830-32834	NN	denotes	Ubr1
T19636	32857-32865	VBN	denotes	involved
T19637	32835-32838	CC	denotes	and
T19638	32839-32847	NN	denotes	Ubce7ip5
T19639	32848-32851	VBP	denotes	are
T19640	32852-32856	RB	denotes	both
T19641	32866-32868	IN	denotes	in
T19642	32869-32876	NN	denotes	protein
T19643	32877-32891	NN	denotes	ubiquitination
T19644	32892-32895	CC	denotes	and
T19645	32896-32900	NN	denotes	Ubr1
T19646	32901-32909	NN	denotes	knockout
T19647	32910-32914	NNS	denotes	mice
T19648	32915-32919	VBP	denotes	show
T19649	32920-32922	DT	denotes	an
T19650	32927-32935	NN	denotes	decrease
T19651	32923-32925	CD	denotes	20
T19652	32925-32926	NN	denotes	%
T19653	32936-32938	IN	denotes	in
T19654	32939-32943	NN	denotes	body
T19655	32944-32950	NN	denotes	weight
T19656	32951-32957	RB	denotes	partly
T19657	32958-32961	IN	denotes	due
T19658	32962-32964	IN	denotes	to
T19659	32965-32966	DT	denotes	a
T19660	32967-32976	NN	denotes	reduction
T19661	32977-32979	IN	denotes	in
T19662	32980-32987	NN	denotes	adipose
T19663	32988-32994	NN	denotes	tissue
T19664	32995-32996	-LRB-	denotes	[
T19665	32999-33001	CD	denotes	51
T19666	32996-32998	CD	denotes	50
T19667	32998-32999	,	denotes	,
T19668	33001-33002	-RRB-	denotes	]
T19669	33002-33003	.	denotes	.
T19670	33003-33160	sentence	denotes	Ptpns1 knockout mice displayed a 10% reduction in body weight [52] and Mmp9 knockout mice show a reduction in size and drastically reduced bone length [53].
T19671	33004-33010	NN	denotes	Ptpns1
T19672	33020-33024	NNS	denotes	mice
T19673	33011-33019	NN	denotes	knockout
T19674	33025-33034	VBD	denotes	displayed
T19675	33035-33036	DT	denotes	a
T19676	33041-33050	NN	denotes	reduction
T19677	33037-33039	CD	denotes	10
T19678	33039-33040	NN	denotes	%
T19679	33051-33053	IN	denotes	in
T19680	33054-33058	NN	denotes	body
T19681	33059-33065	NN	denotes	weight
T19682	33066-33067	-LRB-	denotes	[
T19683	33067-33069	CD	denotes	52
T19684	33069-33070	-RRB-	denotes	]
T19685	33071-33074	CC	denotes	and
T19686	33075-33079	NN	denotes	Mmp9
T19687	33089-33093	NNS	denotes	mice
T19688	33080-33088	NN	denotes	knockout
T19689	33094-33098	VBP	denotes	show
T19690	33099-33100	DT	denotes	a
T19691	33101-33110	NN	denotes	reduction
T19692	33111-33113	IN	denotes	in
T19693	33114-33118	NN	denotes	size
T19694	33119-33122	CC	denotes	and
T19695	33123-33134	RB	denotes	drastically
T19696	33135-33142	VBN	denotes	reduced
T19697	33148-33154	NN	denotes	length
T19698	33143-33147	NN	denotes	bone
T19699	33155-33156	-LRB-	denotes	[
T19700	33156-33158	CD	denotes	53
T19701	33158-33159	-RRB-	denotes	]
T19702	33159-33160	.	denotes	.
T19703	33160-33322	sentence	denotes	All of these genes are excellent functional and positional hg modifier candidate genes and this information can be incorporated into future fine mapping studies.
T19704	33161-33164	DT	denotes	All
T19705	33180-33183	VBP	denotes	are
T19706	33165-33167	IN	denotes	of
T19707	33168-33173	DT	denotes	these
T19708	33174-33179	NNS	denotes	genes
T19709	33184-33193	JJ	denotes	excellent
T19710	33242-33247	NNS	denotes	genes
T19711	33194-33204	JJ	denotes	functional
T19712	33205-33208	CC	denotes	and
T19713	33209-33219	JJ	denotes	positional
T19714	33220-33222	NN	denotes	hg
T19715	33223-33231	NN	denotes	modifier
T19716	33232-33241	NN	denotes	candidate
T19717	33248-33251	CC	denotes	and
T19718	33252-33256	DT	denotes	this
T19719	33257-33268	NN	denotes	information
T19720	33276-33288	VBN	denotes	incorporated
T19721	33269-33272	MD	denotes	can
T19722	33273-33275	VB	denotes	be
T19723	33289-33293	IN	denotes	into
T19724	33294-33300	JJ	denotes	future
T19725	33314-33321	NNS	denotes	studies
T19726	33301-33305	JJ	denotes	fine
T19727	33306-33313	NN	denotes	mapping
T19728	33321-33322	.	denotes	.
T19896	33335-33338	DT	denotes	The
T19897	33354-33361	NNS	denotes	strains
T19898	33339-33344	NN	denotes	speed
T19899	33345-33353	JJ	denotes	congenic
T19900	33379-33386	VBP	denotes	confirm
T19901	33362-33371	VBN	denotes	developed
T19902	33372-33378	RB	denotes	herein
T19903	33387-33397	RB	denotes	previously
T19904	33398-33408	VBN	denotes	identified
T19905	33421-33424	NN	denotes	QTL
T19906	33409-33415	NN	denotes	genome
T19907	33416-33420	JJ	denotes	wide
T19908	33415-33416	HYPH	denotes	-
T19909	33425-33434	VBG	denotes	affecting
T19910	33435-33441	NN	denotes	growth
T19911	33441-33443	,	denotes	,
T19912	33443-33450	NN	denotes	obesity
T19913	33451-33454	CC	denotes	and
T19914	33455-33462	NN	denotes	carcass
T19915	33463-33474	NN	denotes	composition
T19916	33474-33475	.	denotes	.
T19917	33475-33634	sentence	denotes	Our novel congenic development approach on MMU2 provided confirmation of QTL-hg interactions, which will significantly aid in future fine mapping experiments.
T19918	33476-33479	PRP$	denotes	Our
T19919	33507-33515	NN	denotes	approach
T19920	33480-33485	JJ	denotes	novel
T19921	33486-33494	JJ	denotes	congenic
T19922	33495-33506	NN	denotes	development
T19923	33524-33532	VBD	denotes	provided
T19924	33516-33518	IN	denotes	on
T19925	33519-33523	NN	denotes	MMU2
T19926	33533-33545	NN	denotes	confirmation
T19927	33546-33548	IN	denotes	of
T19928	33549-33552	NN	denotes	QTL
T19929	33553-33555	NN	denotes	hg
T19930	33552-33553	HYPH	denotes	-
T19931	33556-33568	NNS	denotes	interactions
T19932	33568-33570	,	denotes	,
T19933	33570-33575	WDT	denotes	which
T19934	33595-33598	VB	denotes	aid
T19935	33576-33580	MD	denotes	will
T19936	33581-33594	RB	denotes	significantly
T19937	33599-33601	IN	denotes	in
T19938	33602-33608	JJ	denotes	future
T19939	33622-33633	NNS	denotes	experiments
T19940	33609-33613	JJ	denotes	fine
T19941	33614-33621	NN	denotes	mapping
T19942	33633-33634	.	denotes	.
T19943	33634-33843	sentence	denotes	The identification of the molecular mediators of QTL-hg epistasis as well as the QTG for the remaining congenics will provide essential information on the molecular genetic architecture of growth and obesity.
T19944	33635-33638	DT	denotes	The
T19945	33639-33653	NN	denotes	identification
T19946	33753-33760	VB	denotes	provide
T19947	33654-33656	IN	denotes	of
T19948	33657-33660	DT	denotes	the
T19949	33671-33680	NNS	denotes	mediators
T19950	33661-33670	JJ	denotes	molecular
T19951	33681-33683	IN	denotes	of
T19952	33684-33687	NN	denotes	QTL
T19953	33688-33690	NN	denotes	hg
T19954	33687-33688	HYPH	denotes	-
T19955	33691-33700	NN	denotes	epistasis
T19956	33701-33703	RB	denotes	as
T19957	33709-33711	IN	denotes	as
T19958	33704-33708	RB	denotes	well
T19959	33712-33715	DT	denotes	the
T19960	33716-33719	NN	denotes	QTG
T19961	33720-33723	IN	denotes	for
T19962	33724-33727	DT	denotes	the
T19963	33738-33747	NNS	denotes	congenics
T19964	33728-33737	VBG	denotes	remaining
T19965	33748-33752	MD	denotes	will
T19966	33761-33770	JJ	denotes	essential
T19967	33771-33782	NN	denotes	information
T19968	33783-33785	IN	denotes	on
T19969	33786-33789	DT	denotes	the
T19970	33808-33820	NN	denotes	architecture
T19971	33790-33799	JJ	denotes	molecular
T19972	33800-33807	JJ	denotes	genetic
T19973	33821-33823	IN	denotes	of
T19974	33824-33830	NN	denotes	growth
T19975	33831-33834	CC	denotes	and
T19976	33835-33842	NN	denotes	obesity
T19977	33842-33843	.	denotes	.
T20228	33854-33859	NN	denotes	Mouse
T20229	33860-33867	NNS	denotes	strains
T20230	33868-33871	CC	denotes	and
T20231	33872-33881	JJ	denotes	husbandry
T20232	33881-33955	sentence	denotes	CAST/EiJ (stock #000928) mice were purchased from the Jackson Laboratory.
T20233	33882-33886	NN	denotes	CAST
T20234	33887-33890	NN	denotes	EiJ
T20235	33886-33887	HYPH	denotes	/
T20236	33907-33911	NNS	denotes	mice
T20237	33891-33892	-LRB-	denotes	(
T20238	33898-33899	NN	denotes	#
T20239	33892-33897	NN	denotes	stock
T20240	33899-33905	CD	denotes	000928
T20241	33905-33906	-RRB-	denotes	)
T20242	33917-33926	VBN	denotes	purchased
T20243	33912-33916	VBD	denotes	were
T20244	33927-33931	IN	denotes	from
T20245	33932-33935	DT	denotes	the
T20246	33944-33954	NNP	denotes	Laboratory
T20247	33936-33943	NNP	denotes	Jackson
T20248	33954-33955	.	denotes	.
T20249	33955-34123	sentence	denotes	The hg mutation was originally identified in a selected outcross line [22] and has been introgressed onto a B6 background via nine backcrosses to create the HG strain.
T20250	33956-33959	DT	denotes	The
T20251	33963-33971	NN	denotes	mutation
T20252	33960-33962	NN	denotes	hg
T20253	33987-33997	VBN	denotes	identified
T20254	33972-33975	VBD	denotes	was
T20255	33976-33986	RB	denotes	originally
T20256	33998-34000	IN	denotes	in
T20257	34001-34002	DT	denotes	a
T20258	34021-34025	NN	denotes	line
T20259	34003-34011	VBN	denotes	selected
T20260	34012-34020	NN	denotes	outcross
T20261	34026-34027	-LRB-	denotes	[
T20262	34027-34029	CD	denotes	22
T20263	34029-34030	-RRB-	denotes	]
T20264	34031-34034	CC	denotes	and
T20265	34035-34038	VBZ	denotes	has
T20266	34044-34056	VBN	denotes	introgressed
T20267	34039-34043	VBN	denotes	been
T20268	34057-34061	IN	denotes	onto
T20269	34062-34063	DT	denotes	a
T20270	34067-34077	NN	denotes	background
T20271	34064-34066	NN	denotes	B6
T20272	34078-34081	IN	denotes	via
T20273	34082-34086	CD	denotes	nine
T20274	34087-34098	NNS	denotes	backcrosses
T20275	34099-34101	TO	denotes	to
T20276	34102-34108	VB	denotes	create
T20277	34109-34112	DT	denotes	the
T20278	34116-34122	NN	denotes	strain
T20279	34113-34115	NN	denotes	HG
T20280	34122-34123	.	denotes	.
T20281	34123-34209	sentence	denotes	HG mice used in this experiment were from the 17th or later generation of inbreeding.
T20282	34124-34126	NN	denotes	HG
T20283	34127-34131	NNS	denotes	mice
T20284	34156-34160	VBD	denotes	were
T20285	34132-34136	VBN	denotes	used
T20286	34137-34139	IN	denotes	in
T20287	34140-34144	DT	denotes	this
T20288	34145-34155	NN	denotes	experiment
T20289	34161-34165	IN	denotes	from
T20290	34166-34169	DT	denotes	the
T20291	34184-34194	NN	denotes	generation
T20292	34170-34174	JJ	denotes	17th
T20293	34175-34177	CC	denotes	or
T20294	34178-34183	JJ	denotes	later
T20295	34195-34197	IN	denotes	of
T20296	34198-34208	NN	denotes	inbreeding
T20297	34208-34209	.	denotes	.
T20298	34209-34503	sentence	denotes	Mice were housed in polycarbonate cages under controlled conditions of temperature (21°C ± 2°C), humidity (40–70%) and lighting (14 h light, 10 h dark, lights on at 7 AM), and managed according to the guidelines of the American Association for Accreditation of Laboratory Animal Care (AAALAC).
T20299	34210-34214	NNS	denotes	Mice
T20300	34220-34226	VBN	denotes	housed
T20301	34215-34219	VBD	denotes	were
T20302	34227-34229	IN	denotes	in
T20303	34230-34243	NN	denotes	polycarbonate
T20304	34244-34249	NNS	denotes	cages
T20305	34250-34255	IN	denotes	under
T20306	34256-34266	VBN	denotes	controlled
T20307	34267-34277	NNS	denotes	conditions
T20308	34278-34280	IN	denotes	of
T20309	34281-34292	NN	denotes	temperature
T20310	34293-34294	-LRB-	denotes	(
T20311	34296-34298	NN	denotes	°C
T20312	34294-34296	CD	denotes	21
T20313	34299-34300	SYM	denotes	±
T20314	34301-34302	CD	denotes	2
T20315	34302-34304	NN	denotes	°C
T20316	34304-34305	-RRB-	denotes	)
T20317	34305-34307	,	denotes	,
T20318	34307-34315	NN	denotes	humidity
T20319	34316-34317	-LRB-	denotes	(
T20320	34322-34323	NN	denotes	%
T20321	34317-34319	CD	denotes	40
T20322	34320-34322	CD	denotes	70
T20323	34319-34320	SYM	denotes	–
T20324	34323-34324	-RRB-	denotes	)
T20325	34325-34328	CC	denotes	and
T20326	34329-34337	NN	denotes	lighting
T20327	34338-34339	-LRB-	denotes	(
T20328	34356-34360	NN	denotes	dark
T20329	34339-34341	CD	denotes	14
T20330	34342-34343	NN	denotes	h
T20331	34344-34349	NN	denotes	light
T20332	34349-34351	,	denotes	,
T20333	34351-34353	CD	denotes	10
T20334	34354-34355	NN	denotes	h
T20335	34360-34362	,	denotes	,
T20336	34362-34368	NNS	denotes	lights
T20337	34369-34371	RB	denotes	on
T20338	34372-34374	IN	denotes	at
T20339	34375-34376	CD	denotes	7
T20340	34377-34379	NN	denotes	AM
T20341	34379-34380	-RRB-	denotes	)
T20342	34380-34382	,	denotes	,
T20343	34382-34385	CC	denotes	and
T20344	34386-34393	VBD	denotes	managed
T20345	34394-34403	VBG	denotes	according
T20346	34404-34406	IN	denotes	to
T20347	34407-34410	DT	denotes	the
T20348	34411-34421	NNS	denotes	guidelines
T20349	34422-34424	IN	denotes	of
T20350	34425-34428	DT	denotes	the
T20351	34438-34449	NNP	denotes	Association
T20352	34429-34437	NNP	denotes	American
T20353	34450-34453	IN	denotes	for
T20354	34454-34467	NNP	denotes	Accreditation
T20355	34468-34470	IN	denotes	of
T20356	34471-34481	NNP	denotes	Laboratory
T20357	34482-34488	NNP	denotes	Animal
T20358	34489-34493	NNP	denotes	Care
T20359	34494-34495	-LRB-	denotes	(
T20360	34495-34501	NNP	denotes	AAALAC
T20361	34501-34502	-RRB-	denotes	)
T20362	34502-34503	.	denotes	.
T20779	34505-34515	NN	denotes	Genotyping
T20780	34515-34719	sentence	denotes	DNA for genotyping was isolated from 1.0–2.0 mm tail clips by digesting with Proteinase K (Fisher) at 55°C in a buffer composed of 0.45% NP40 (Sigma), 0.45% Tween 20 (Fisher) and 1X PCR buffer (Promega).
T20781	34516-34519	NN	denotes	DNA
T20782	34539-34547	VBN	denotes	isolated
T20783	34520-34523	IN	denotes	for
T20784	34524-34534	NN	denotes	genotyping
T20785	34535-34538	VBD	denotes	was
T20786	34548-34552	IN	denotes	from
T20787	34553-34556	CD	denotes	1.0
T20788	34557-34560	CD	denotes	2.0
T20789	34556-34557	SYM	denotes	–
T20790	34561-34563	NN	denotes	mm
T20791	34569-34574	NNS	denotes	clips
T20792	34564-34568	NN	denotes	tail
T20794	34578-34587	VBG	denotes	digesting
T20795	34588-34592	IN	denotes	with
T20796	34593-34603	NN	denotes	Proteinase
T20797	34604-34605	NN	denotes	K
T20798	34606-34607	-LRB-	denotes	(
T20799	34607-34613	NNP	denotes	Fisher
T20800	34613-34614	-RRB-	denotes	)
T20801	34615-34617	IN	denotes	at
T20802	34618-34620	CD	denotes	55
T20803	34620-34622	NN	denotes	°C
T20804	34623-34625	IN	denotes	in
T20805	34626-34627	DT	denotes	a
T20806	34628-34634	NN	denotes	buffer
T20807	34635-34643	VBN	denotes	composed
T20808	34644-34646	IN	denotes	of
T20809	34647-34651	CD	denotes	0.45
T20810	34651-34652	NN	denotes	%
T20811	34653-34657	NN	denotes	NP40
T20812	34658-34659	-LRB-	denotes	(
T20813	34659-34664	NNP	denotes	Sigma
T20814	34664-34665	-RRB-	denotes	)
T20815	34665-34667	,	denotes	,
T20816	34667-34671	CD	denotes	0.45
T20817	34671-34672	NN	denotes	%
T20818	34673-34678	NN	denotes	Tween
T20819	34679-34681	CD	denotes	20
T20820	34682-34683	-LRB-	denotes	(
T20821	34683-34689	NNP	denotes	Fisher
T20822	34689-34690	-RRB-	denotes	)
T20823	34691-34694	CC	denotes	and
T20824	34695-34697	NN	denotes	1X
T20825	34702-34708	NN	denotes	buffer
T20826	34698-34701	NN	denotes	PCR
T20827	34709-34710	-LRB-	denotes	(
T20828	34710-34717	NNP	denotes	Promega
T20829	34717-34718	-RRB-	denotes	)
T20830	34718-34719	.	denotes	.
T20831	34719-34837	sentence	denotes	The product of this digestion was diluted (1:10) in sterile H2O and used for genotyping without further purification.
T20832	34720-34723	DT	denotes	The
T20833	34724-34731	NN	denotes	product
T20834	34754-34761	VBN	denotes	diluted
T20835	34732-34734	IN	denotes	of
T20836	34735-34739	DT	denotes	this
T20837	34740-34749	NN	denotes	digestion
T20838	34750-34753	VBD	denotes	was
T20839	34762-34763	-LRB-	denotes	(
T20840	34763-34764	CD	denotes	1
T20841	34764-34765	SYM	denotes	:
T20842	34765-34767	CD	denotes	10
T20843	34767-34768	-RRB-	denotes	)
T20844	34769-34771	IN	denotes	in
T20845	34772-34779	JJ	denotes	sterile
T20846	34780-34783	NN	denotes	H2O
T20847	34784-34787	CC	denotes	and
T20848	34788-34792	VBN	denotes	used
T20849	34793-34796	IN	denotes	for
T20850	34797-34807	NN	denotes	genotyping
T20851	34808-34815	IN	denotes	without
T20852	34816-34823	JJ	denotes	further
T20853	34824-34836	NN	denotes	purification
T20854	34836-34837	.	denotes	.
T20855	34837-34931	sentence	denotes	Microsatellite genotyping was performed using standard PCR and gel electrophoresis protocols.
T20856	34838-34852	NN	denotes	Microsatellite
T20857	34853-34863	NN	denotes	genotyping
T20858	34868-34877	VBN	denotes	performed
T20859	34864-34867	VBD	denotes	was
T20860	34878-34883	VBG	denotes	using
T20861	34884-34892	JJ	denotes	standard
T20862	34921-34930	NNS	denotes	protocols
T20863	34893-34896	NN	denotes	PCR
T20864	34897-34900	CC	denotes	and
T20865	34901-34904	NN	denotes	gel
T20866	34905-34920	NN	denotes	electrophoresis
T20867	34930-34931	.	denotes	.
T20868	34931-35006	sentence	denotes	Reaction conditions for each marker are listed in Additional File 1 and 2.
T20869	34932-34940	NN	denotes	Reaction
T20870	34941-34951	NNS	denotes	conditions
T20871	34972-34978	VBN	denotes	listed
T20872	34952-34955	IN	denotes	for
T20873	34956-34960	DT	denotes	each
T20874	34961-34967	NN	denotes	marker
T20875	34968-34971	VBP	denotes	are
T20876	34979-34981	IN	denotes	in
T20877	34982-34992	JJ	denotes	Additional
T20878	34998-34999	CD	denotes	1
T20879	34993-34997	NN	denotes	File
T20880	35000-35003	CC	denotes	and
T20881	35004-35005	CD	denotes	2
T20882	35005-35006	.	denotes	.
T20883	35006-35084	sentence	denotes	MMU2 congenic mice were genotyped for hg using a two primer genotyping assay.
T20884	35007-35011	NN	denotes	MMU2
T20885	35012-35020	JJ	denotes	congenic
T20886	35021-35025	NNS	denotes	mice
T20887	35031-35040	VBN	denotes	genotyped
T20888	35026-35030	VBD	denotes	were
T20889	35041-35044	IN	denotes	for
T20890	35045-35047	NN	denotes	hg
T20891	35048-35053	VBG	denotes	using
T20892	35054-35055	DT	denotes	a
T20893	35078-35083	NN	denotes	assay
T20894	35056-35059	CD	denotes	two
T20895	35060-35066	NN	denotes	primer
T20896	35067-35077	NN	denotes	genotyping
T20897	35083-35084	.	denotes	.
T20898	35084-35233	sentence	denotes	One primer set (HG-F, ctcctgtctgggctgtgag and HG-R, caaaggcagaagtggggtaa) spanned the hg deletion producing a 447 bp product in hg/hg and +/hg mice.
T20899	35085-35088	CD	denotes	One
T20900	35096-35099	NN	denotes	set
T20901	35089-35095	NN	denotes	primer
T20902	35159-35166	VBD	denotes	spanned
T20903	35100-35101	-LRB-	denotes	(
T20904	35101-35103	NN	denotes	HG
T20905	35104-35105	NN	denotes	F
T20906	35103-35104	HYPH	denotes	-
T20907	35105-35107	,	denotes	,
T20908	35107-35126	NN	denotes	ctcctgtctgggctgtgag
T20909	35127-35130	CC	denotes	and
T20910	35131-35133	NN	denotes	HG
T20911	35134-35135	NN	denotes	R
T20912	35133-35134	HYPH	denotes	-
T20913	35135-35137	,	denotes	,
T20914	35137-35157	NN	denotes	caaaggcagaagtggggtaa
T20915	35157-35158	-RRB-	denotes	)
T20916	35167-35170	DT	denotes	the
T20917	35174-35182	NN	denotes	deletion
T20918	35171-35173	NN	denotes	hg
T20919	35183-35192	VBG	denotes	producing
T20920	35193-35194	DT	denotes	a
T20921	35202-35209	NN	denotes	product
T20922	35195-35198	CD	denotes	447
T20923	35199-35201	NN	denotes	bp
T20924	35210-35212	IN	denotes	in
T20925	35213-35215	NN	denotes	hg
T20926	35216-35218	NN	denotes	hg
T20927	35215-35216	HYPH	denotes	/
T20928	35228-35232	NNS	denotes	mice
T20929	35219-35222	CC	denotes	and
T20930	35223-35224	SYM	denotes	+
T20931	35225-35227	NN	denotes	hg
T20932	35224-35225	HYPH	denotes	/
T20933	35232-35233	.	denotes	.
T20934	35233-35410	sentence	denotes	The other set (CRADD3a.F, gtccatcagcattcctgaaa and CRADD3.R, tgtccagcaacagcattgtc) amplified a 232 bp Cradd amplicon (located within the hg deletion) in +/+ and +/hg mice [54].
T20935	35234-35237	DT	denotes	The
T20936	35244-35247	NN	denotes	set
T20937	35238-35243	JJ	denotes	other
T20938	35317-35326	VBD	denotes	amplified
T20939	35248-35249	-LRB-	denotes	(
T20940	35249-35258	NN	denotes	CRADD3a.F
T20941	35258-35260	,	denotes	,
T20942	35260-35280	NN	denotes	gtccatcagcattcctgaaa
T20943	35281-35284	CC	denotes	and
T20944	35285-35293	NN	denotes	CRADD3.R
T20945	35293-35295	,	denotes	,
T20946	35295-35315	NN	denotes	tgtccagcaacagcattgtc
T20947	35315-35316	-RRB-	denotes	)
T20948	35327-35328	DT	denotes	a
T20949	35342-35350	NN	denotes	amplicon
T20950	35329-35332	CD	denotes	232
T20951	35333-35335	NN	denotes	bp
T20952	35336-35341	NN	denotes	Cradd
T20953	35351-35352	-LRB-	denotes	(
T20954	35352-35359	VBN	denotes	located
T20955	35360-35366	IN	denotes	within
T20956	35367-35370	DT	denotes	the
T20957	35374-35382	NN	denotes	deletion
T20958	35371-35373	NN	denotes	hg
T20959	35382-35383	-RRB-	denotes	)
T20960	35384-35386	IN	denotes	in
T20961	35387-35388	SYM	denotes	+
T20962	35389-35390	SYM	denotes	+
T20963	35388-35389	HYPH	denotes	/
T20964	35400-35404	NNS	denotes	mice
T20965	35391-35394	CC	denotes	and
T20966	35395-35396	SYM	denotes	+
T20967	35397-35399	NN	denotes	hg
T20968	35396-35397	HYPH	denotes	/
T20969	35405-35406	-LRB-	denotes	[
T20970	35406-35408	CD	denotes	54
T20971	35408-35409	-RRB-	denotes	]
T20972	35409-35410	.	denotes	.
T20973	35410-35489	sentence	denotes	The PCR annealing temperature was 55°C and the MgCl2 concentration was 1.5 mM.
T20974	35411-35414	DT	denotes	The
T20975	35429-35440	NN	denotes	temperature
T20976	35415-35418	NN	denotes	PCR
T20977	35419-35428	VBG	denotes	annealing
T20978	35441-35444	VBD	denotes	was
T20979	35445-35447	CD	denotes	55
T20980	35447-35449	NN	denotes	°C
T20981	35450-35453	CC	denotes	and
T20982	35454-35457	DT	denotes	the
T20983	35464-35477	NN	denotes	concentration
T20984	35458-35463	NN	denotes	MgCl2
T20985	35478-35481	VBD	denotes	was
T20986	35482-35485	CD	denotes	1.5
T20987	35486-35488	NN	denotes	mM
T20988	35488-35489	.	denotes	.
T21607	35491-35502	NN	denotes	Development
T21608	35503-35505	IN	denotes	of
T21609	35506-35513	NN	denotes	B6.CAST
T21610	35526-35530	NN	denotes	MMU2
T21611	35514-35517	CC	denotes	and
T21612	35518-35525	NN	denotes	HG.CAST
T21613	35546-35553	NNS	denotes	strains
T21614	35531-35536	NN	denotes	speed
T21615	35537-35545	JJ	denotes	congenic
T21616	35553-35679	sentence	denotes	All speed congenic strains were developed starting with an initial cross between a CAST male and HG females (Figure 1) [5,6].
T21617	35554-35557	DT	denotes	All
T21618	35573-35580	NNS	denotes	strains
T21619	35558-35563	NN	denotes	speed
T21620	35564-35572	JJ	denotes	congenic
T21621	35586-35595	VBN	denotes	developed
T21622	35581-35585	VBD	denotes	were
T21623	35596-35604	VBG	denotes	starting
T21624	35605-35609	IN	denotes	with
T21625	35610-35612	DT	denotes	an
T21626	35621-35626	NN	denotes	cross
T21627	35613-35620	JJ	denotes	initial
T21628	35627-35634	IN	denotes	between
T21629	35635-35636	DT	denotes	a
T21630	35642-35646	NN	denotes	male
T21631	35637-35641	NN	denotes	CAST
T21632	35647-35650	CC	denotes	and
T21633	35651-35653	NN	denotes	HG
T21634	35654-35661	NNS	denotes	females
T21635	35662-35663	-LRB-	denotes	(
T21636	35663-35669	NN	denotes	Figure
T21637	35670-35671	CD	denotes	1
T21638	35671-35672	-RRB-	denotes	)
T21639	35673-35674	-LRB-	denotes	[
T21640	35676-35677	CD	denotes	6
T21641	35674-35675	CD	denotes	5
T21642	35675-35676	,	denotes	,
T21643	35677-35678	-RRB-	denotes	]
T21644	35678-35679	.	denotes	.
T21645	35679-35729	sentence	denotes	Male F1 mice were then backcrossed to HG females.
T21646	35680-35684	JJ	denotes	Male
T21647	35688-35692	NNS	denotes	mice
T21648	35685-35687	NN	denotes	F1
T21649	35703-35714	VBN	denotes	backcrossed
T21650	35693-35697	VBD	denotes	were
T21651	35698-35702	RB	denotes	then
T21652	35715-35717	IN	denotes	to
T21653	35718-35720	NN	denotes	HG
T21654	35721-35728	NNS	denotes	females
T21655	35728-35729	.	denotes	.
T21656	35729-35882	sentence	denotes	All agouti (the dominant nonagouti (a) locus is located at 154.8 Mbp on MMU2) N2 males were genotyped for 79 microsatellite markers (Additional File 1).
T21657	35730-35733	DT	denotes	All
T21658	35811-35816	NNS	denotes	males
T21659	35734-35740	NN	denotes	agouti
T21660	35741-35742	-LRB-	denotes	(
T21661	35778-35785	VBN	denotes	located
T21662	35742-35745	DT	denotes	the
T21663	35769-35774	NN	denotes	locus
T21664	35746-35754	JJ	denotes	dominant
T21665	35755-35764	JJ	denotes	nonagouti
T21666	35766-35767	NN	denotes	a
T21667	35765-35766	-LRB-	denotes	(
T21668	35767-35768	-RRB-	denotes	)
T21669	35775-35777	VBZ	denotes	is
T21670	35786-35788	IN	denotes	at
T21671	35789-35794	CD	denotes	154.8
T21672	35795-35798	NN	denotes	Mbp
T21673	35799-35801	IN	denotes	on
T21674	35802-35806	NN	denotes	MMU2
T21675	35806-35807	-RRB-	denotes	)
T21676	35808-35810	NN	denotes	N2
T21677	35822-35831	VBN	denotes	genotyped
T21678	35817-35821	VBD	denotes	were
T21679	35832-35835	IN	denotes	for
T21680	35836-35838	CD	denotes	79
T21681	35854-35861	NNS	denotes	markers
T21682	35839-35853	NN	denotes	microsatellite
T21683	35862-35863	-LRB-	denotes	(
T21684	35874-35878	NN	denotes	File
T21685	35863-35873	JJ	denotes	Additional
T21686	35879-35880	CD	denotes	1
T21687	35880-35881	-RRB-	denotes	)
T21688	35881-35882	.	denotes	.
T21689	35882-36030	sentence	denotes	These markers were evenly spaced across the genome, except in regions previously identified as harboring QTL [1], which were more densely screened.
T21690	35883-35888	DT	denotes	These
T21691	35889-35896	NNS	denotes	markers
T21692	35909-35915	VBN	denotes	spaced
T21693	35897-35901	VBD	denotes	were
T21694	35902-35908	RB	denotes	evenly
T21695	35916-35922	IN	denotes	across
T21696	35923-35926	DT	denotes	the
T21697	35927-35933	NN	denotes	genome
T21698	35933-35935	,	denotes	,
T21699	35935-35941	RB	denotes	except
T21700	35942-35944	IN	denotes	in
T21701	35945-35952	NNS	denotes	regions
T21702	35953-35963	RB	denotes	previously
T21703	35964-35974	VBN	denotes	identified
T21704	35975-35977	IN	denotes	as
T21705	35978-35987	VBG	denotes	harboring
T21706	35988-35991	NN	denotes	QTL
T21707	35992-35993	-LRB-	denotes	[
T21708	35993-35994	CD	denotes	1
T21709	35994-35995	-RRB-	denotes	]
T21710	35995-35997	,	denotes	,
T21711	35997-36002	WDT	denotes	which
T21712	36021-36029	VBN	denotes	screened
T21713	36003-36007	VBD	denotes	were
T21714	36008-36012	RBR	denotes	more
T21715	36013-36020	RB	denotes	densely
T21716	36029-36030	.	denotes	.
T21717	36030-36196	sentence	denotes	The "best" N2 agouti male with the lowest level of genome-wide unwanted heterozygosity while maintaining CAST alleles for all MMU2 markers was selected for breeding.
T21718	36031-36034	DT	denotes	The
T21719	36052-36056	NN	denotes	male
T21720	36035-36036	``	denotes	"
T21721	36036-36040	JJS	denotes	best
T21722	36040-36041	''	denotes	"
T21723	36042-36044	NN	denotes	N2
T21724	36045-36051	NN	denotes	agouti
T21725	36174-36182	VBN	denotes	selected
T21726	36057-36061	IN	denotes	with
T21727	36062-36065	DT	denotes	the
T21728	36073-36078	NN	denotes	level
T21729	36066-36072	JJS	denotes	lowest
T21730	36079-36081	IN	denotes	of
T21731	36082-36088	NN	denotes	genome
T21732	36089-36093	JJ	denotes	wide
T21733	36088-36089	HYPH	denotes	-
T21734	36103-36117	NN	denotes	heterozygosity
T21735	36094-36102	JJ	denotes	unwanted
T21736	36118-36123	IN	denotes	while
T21737	36124-36135	VBG	denotes	maintaining
T21738	36136-36140	NN	denotes	CAST
T21739	36141-36148	NNS	denotes	alleles
T21740	36149-36152	IN	denotes	for
T21741	36153-36156	DT	denotes	all
T21742	36162-36169	NNS	denotes	markers
T21743	36157-36161	NN	denotes	MMU2
T21744	36170-36173	VBD	denotes	was
T21745	36183-36186	IN	denotes	for
T21746	36187-36195	NN	denotes	breeding
T21747	36195-36196	.	denotes	.
T21748	36196-36330	sentence	denotes	This selection scheme was used at each generation until a N4 male was identified as homozygous HG for all markers typed outside MMU2.
T21749	36197-36201	DT	denotes	This
T21750	36212-36218	NN	denotes	scheme
T21751	36202-36211	NN	denotes	selection
T21752	36223-36227	VBN	denotes	used
T21753	36219-36222	VBD	denotes	was
T21754	36228-36230	IN	denotes	at
T21755	36231-36235	DT	denotes	each
T21756	36236-36246	NN	denotes	generation
T21757	36247-36252	IN	denotes	until
T21758	36267-36277	VBN	denotes	identified
T21759	36253-36254	DT	denotes	a
T21760	36258-36262	NN	denotes	male
T21761	36255-36257	NN	denotes	N4
T21762	36263-36266	VBD	denotes	was
T21763	36278-36280	IN	denotes	as
T21764	36281-36291	JJ	denotes	homozygous
T21765	36292-36294	NN	denotes	HG
T21766	36295-36298	IN	denotes	for
T21767	36299-36302	DT	denotes	all
T21768	36303-36310	NNS	denotes	markers
T21769	36311-36316	VBN	denotes	typed
T21770	36317-36324	IN	denotes	outside
T21771	36325-36329	NN	denotes	MMU2
T21772	36329-36330	.	denotes	.
T21773	36330-36474	sentence	denotes	After an additional backcross to HG females, recombinant males were identified providing the foundation for the four overlapping donor regions.
T21774	36331-36336	IN	denotes	After
T21775	36399-36409	VBN	denotes	identified
T21776	36337-36339	DT	denotes	an
T21777	36351-36360	NN	denotes	backcross
T21778	36340-36350	JJ	denotes	additional
T21779	36361-36363	IN	denotes	to
T21780	36364-36366	NN	denotes	HG
T21781	36367-36374	NNS	denotes	females
T21782	36374-36376	,	denotes	,
T21783	36376-36387	JJ	denotes	recombinant
T21784	36388-36393	NNS	denotes	males
T21785	36394-36398	VBD	denotes	were
T21786	36410-36419	VBG	denotes	providing
T21787	36420-36423	DT	denotes	the
T21788	36424-36434	NN	denotes	foundation
T21789	36435-36438	IN	denotes	for
T21790	36439-36442	DT	denotes	the
T21791	36466-36473	NNS	denotes	regions
T21792	36443-36447	CD	denotes	four
T21793	36448-36459	VBG	denotes	overlapping
T21794	36460-36465	NN	denotes	donor
T21795	36473-36474	.	denotes	.
T21796	36474-36629	sentence	denotes	Selected recombinant males were then backcrossed to both B6 and HG females to create strains, which were B6 (+/+) or HG (hg/hg) and heterozygous congenic.
T21797	36475-36483	VBN	denotes	Selected
T21798	36496-36501	NNS	denotes	males
T21799	36484-36495	JJ	denotes	recombinant
T21800	36512-36523	VBN	denotes	backcrossed
T21801	36502-36506	VBD	denotes	were
T21802	36507-36511	RB	denotes	then
T21803	36524-36526	IN	denotes	to
T21804	36527-36531	CC	denotes	both
T21805	36532-36534	NN	denotes	B6
T21806	36542-36549	NNS	denotes	females
T21807	36535-36538	CC	denotes	and
T21808	36539-36541	NN	denotes	HG
T21809	36550-36552	TO	denotes	to
T21810	36553-36559	VB	denotes	create
T21811	36560-36567	NNS	denotes	strains
T21812	36567-36569	,	denotes	,
T21813	36569-36574	WDT	denotes	which
T21814	36575-36579	VBD	denotes	were
T21815	36580-36582	NN	denotes	B6
T21816	36620-36628	JJ	denotes	congenic
T21817	36583-36584	-LRB-	denotes	(
T21818	36586-36587	SYM	denotes	+
T21819	36584-36585	SYM	denotes	+
T21820	36585-36586	HYPH	denotes	/
T21821	36587-36588	-RRB-	denotes	)
T21822	36589-36591	CC	denotes	or
T21823	36592-36594	NN	denotes	HG
T21824	36595-36596	-LRB-	denotes	(
T21825	36599-36601	NN	denotes	hg
T21826	36596-36598	NN	denotes	hg
T21827	36598-36599	HYPH	denotes	/
T21828	36601-36602	-RRB-	denotes	)
T21829	36603-36606	CC	denotes	and
T21830	36607-36619	JJ	denotes	heterozygous
T21831	36628-36629	.	denotes	.
T21832	36629-36704	sentence	denotes	These mice were intermated to produce homozygous founders for each strain.
T21833	36630-36635	DT	denotes	These
T21834	36636-36640	NNS	denotes	mice
T21835	36646-36656	VBN	denotes	intermated
T21836	36641-36645	VBD	denotes	were
T21837	36657-36659	TO	denotes	to
T21838	36660-36667	VB	denotes	produce
T21839	36668-36678	JJ	denotes	homozygous
T21840	36679-36687	NNS	denotes	founders
T21841	36688-36691	IN	denotes	for
T21842	36692-36696	DT	denotes	each
T21843	36697-36703	NN	denotes	strain
T21844	36703-36704	.	denotes	.
T21845	36704-36918	sentence	denotes	This novel breeding scheme created four identical founder congenics on two backgrounds B6 (+/+) and HG (hg/hg), which formed the basis for our examination of interactions caused by the presence of the hg deletion.
T21846	36705-36709	DT	denotes	This
T21847	36725-36731	NN	denotes	scheme
T21848	36710-36715	JJ	denotes	novel
T21849	36716-36724	VBG	denotes	breeding
T21850	36732-36739	VBD	denotes	created
T21851	36740-36744	CD	denotes	four
T21852	36763-36772	NNS	denotes	congenics
T21853	36745-36754	JJ	denotes	identical
T21854	36755-36762	NN	denotes	founder
T21855	36773-36775	IN	denotes	on
T21856	36776-36779	CD	denotes	two
T21857	36780-36791	NNS	denotes	backgrounds
T21858	36792-36794	NN	denotes	B6
T21859	36795-36796	-LRB-	denotes	(
T21860	36798-36799	SYM	denotes	+
T21861	36796-36797	SYM	denotes	+
T21862	36797-36798	HYPH	denotes	/
T21863	36799-36800	-RRB-	denotes	)
T21864	36801-36804	CC	denotes	and
T21865	36805-36807	NN	denotes	HG
T21866	36808-36809	-LRB-	denotes	(
T21867	36812-36814	NN	denotes	hg
T21868	36809-36811	NN	denotes	hg
T21869	36811-36812	HYPH	denotes	/
T21870	36814-36815	-RRB-	denotes	)
T21871	36815-36817	,	denotes	,
T21872	36817-36822	WDT	denotes	which
T21873	36823-36829	VBD	denotes	formed
T21874	36830-36833	DT	denotes	the
T21875	36834-36839	NN	denotes	basis
T21876	36840-36843	IN	denotes	for
T21877	36844-36847	PRP$	denotes	our
T21878	36848-36859	NN	denotes	examination
T21879	36860-36862	IN	denotes	of
T21880	36863-36875	NNS	denotes	interactions
T21881	36876-36882	VBN	denotes	caused
T21882	36883-36885	IN	denotes	by
T21883	36886-36889	DT	denotes	the
T21884	36890-36898	NN	denotes	presence
T21885	36899-36901	IN	denotes	of
T21886	36902-36905	DT	denotes	the
T21887	36909-36917	NN	denotes	deletion
T21888	36906-36908	NN	denotes	hg
T21889	36917-36918	.	denotes	.
T21890	36918-36993	sentence	denotes	MMU2 speed congenic strains were maintained through brother-sister mating.
T21891	36919-36923	NN	denotes	MMU2
T21892	36939-36946	NNS	denotes	strains
T21893	36924-36929	NN	denotes	speed
T21894	36930-36938	JJ	denotes	congenic
T21895	36952-36962	VBN	denotes	maintained
T21896	36947-36951	VBD	denotes	were
T21897	36963-36970	IN	denotes	through
T21898	36971-36978	NN	denotes	brother
T21899	36979-36985	NN	denotes	sister
T21900	36978-36979	HYPH	denotes	-
T21901	36986-36992	NN	denotes	mating
T21902	36992-36993	.	denotes	.
T21903	36993-37158	sentence	denotes	Once each congenic was stabilized, 20 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T21904	36994-36998	RB	denotes	Once
T21905	37017-37027	VBN	denotes	stabilized
T21906	36999-37003	DT	denotes	each
T21907	37004-37012	JJ	denotes	congenic
T21908	37013-37016	VBD	denotes	was
T21909	37071-37075	VBN	denotes	used
T21910	37027-37029	,	denotes	,
T21911	37029-37031	CD	denotes	20
T21912	37058-37065	NNS	denotes	markers
T21913	37032-37042	JJ	denotes	additional
T21914	37043-37057	NN	denotes	microsatellite
T21915	37066-37070	VBD	denotes	were
T21916	37076-37078	TO	denotes	to
T21917	37079-37085	VB	denotes	refine
T21918	37086-37089	DT	denotes	the
T21919	37090-37098	NN	denotes	position
T21920	37099-37101	IN	denotes	of
T21921	37102-37106	DT	denotes	each
T21922	37132-37137	NN	denotes	point
T21923	37107-37115	JJ	denotes	congenic
T21924	37116-37127	JJ	denotes	recombinant
T21925	37128-37131	NN	denotes	end
T21926	37138-37139	-LRB-	denotes	(
T21927	37150-37154	NN	denotes	File
T21928	37139-37149	JJ	denotes	Additional
T21929	37155-37156	CD	denotes	2
T21930	37156-37157	-RRB-	denotes	)
T21931	37157-37158	.	denotes	.
T22598	37160-37171	NN	denotes	Development
T22599	37172-37174	IN	denotes	of
T22600	37175-37182	NN	denotes	HG.CAST
T22601	37198-37205	NNS	denotes	strains
T22602	37183-37188	NN	denotes	speed
T22603	37189-37197	JJ	denotes	congenic
T22604	37206-37209	IN	denotes	for
T22605	37210-37213	NN	denotes	MMU
T22606	37213-37214	CD	denotes	1
T22607	37214-37216	,	denotes	,
T22608	37216-37217	CD	denotes	5
T22609	37217-37219	,	denotes	,
T22610	37219-37220	CD	denotes	8
T22611	37220-37222	,	denotes	,
T22612	37222-37223	CD	denotes	9
T22613	37223-37225	,	denotes	,
T22614	37225-37227	CD	denotes	11
T22615	37228-37231	CC	denotes	and
T22616	37232-37234	CD	denotes	17
T22617	37234-37537	sentence	denotes	All black N2 males from the first two crosses described above were genotyped for 12 markers (D1Mit432, -480, D5Mit353, -311, D9Mit60, -262, D11Mit5, -67, D8Mit234, -211 and D17Mit28 and -142), two spanning each of the six QTL harboring regions (MMU1, 5, 8, 9, 11 and 17; Table 1 and Additional File 1).
T22618	37235-37238	DT	denotes	All
T22619	37248-37253	NNS	denotes	males
T22620	37239-37244	JJ	denotes	black
T22621	37245-37247	NN	denotes	N2
T22622	37302-37311	VBN	denotes	genotyped
T22623	37254-37258	IN	denotes	from
T22624	37259-37262	DT	denotes	the
T22625	37273-37280	NNS	denotes	crosses
T22626	37263-37268	JJ	denotes	first
T22627	37269-37272	CD	denotes	two
T22628	37281-37290	VBN	denotes	described
T22629	37291-37296	RB	denotes	above
T22630	37297-37301	VBD	denotes	were
T22631	37312-37315	IN	denotes	for
T22632	37316-37318	CD	denotes	12
T22633	37319-37326	NNS	denotes	markers
T22634	37327-37328	-LRB-	denotes	(
T22635	37328-37336	NN	denotes	D1Mit432
T22636	37336-37338	,	denotes	,
T22637	37338-37339	SYM	denotes	-
T22638	37339-37342	CD	denotes	480
T22639	37342-37344	,	denotes	,
T22640	37344-37352	NN	denotes	D5Mit353
T22641	37352-37354	,	denotes	,
T22642	37354-37355	SYM	denotes	-
T22643	37355-37358	CD	denotes	311
T22644	37358-37360	,	denotes	,
T22645	37360-37367	NN	denotes	D9Mit60
T22646	37367-37369	,	denotes	,
T22647	37369-37370	SYM	denotes	-
T22648	37370-37373	CD	denotes	262
T22649	37373-37375	,	denotes	,
T22650	37375-37382	NN	denotes	D11Mit5
T22651	37382-37384	,	denotes	,
T22652	37384-37385	SYM	denotes	-
T22653	37385-37387	CD	denotes	67
T22654	37387-37389	,	denotes	,
T22655	37389-37397	NN	denotes	D8Mit234
T22656	37397-37399	,	denotes	,
T22657	37399-37400	SYM	denotes	-
T22658	37400-37403	CD	denotes	211
T22659	37404-37407	CC	denotes	and
T22660	37408-37416	NN	denotes	D17Mit28
T22661	37417-37420	CC	denotes	and
T22662	37421-37422	SYM	denotes	-
T22663	37422-37425	CD	denotes	142
T22664	37425-37426	-RRB-	denotes	)
T22665	37426-37428	,	denotes	,
T22666	37428-37431	CD	denotes	two
T22667	37432-37440	VBG	denotes	spanning
T22668	37441-37445	DT	denotes	each
T22669	37446-37448	IN	denotes	of
T22670	37449-37452	DT	denotes	the
T22671	37471-37478	NNS	denotes	regions
T22672	37453-37456	CD	denotes	six
T22673	37457-37460	NNS	denotes	QTL
T22674	37461-37470	VBG	denotes	harboring
T22675	37479-37480	-LRB-	denotes	(
T22676	37480-37483	NN	denotes	MMU
T22677	37483-37484	CD	denotes	1
T22678	37484-37486	,	denotes	,
T22679	37486-37487	CD	denotes	5
T22680	37487-37489	,	denotes	,
T22681	37489-37490	CD	denotes	8
T22682	37490-37492	,	denotes	,
T22683	37492-37493	CD	denotes	9
T22684	37493-37495	,	denotes	,
T22685	37495-37497	CD	denotes	11
T22686	37498-37501	CC	denotes	and
T22687	37502-37504	CD	denotes	17
T22688	37504-37505	:	denotes	;
T22689	37506-37511	NN	denotes	Table
T22690	37512-37513	CD	denotes	1
T22691	37514-37517	CC	denotes	and
T22692	37518-37528	JJ	denotes	Additional
T22693	37529-37533	NN	denotes	File
T22694	37534-37535	CD	denotes	1
T22695	37535-37536	-RRB-	denotes	)
T22696	37536-37537	.	denotes	.
T22697	37537-37613	sentence	denotes	Markers were selected to capture, at a minimum, the 2-LOD support interval.
T22698	37538-37545	NNS	denotes	Markers
T22699	37551-37559	VBN	denotes	selected
T22700	37546-37550	VBD	denotes	were
T22701	37560-37562	TO	denotes	to
T22702	37563-37570	VB	denotes	capture
T22703	37570-37572	,	denotes	,
T22704	37572-37574	IN	denotes	at
T22705	37575-37576	DT	denotes	a
T22706	37577-37584	NN	denotes	minimum
T22707	37584-37586	,	denotes	,
T22708	37586-37589	DT	denotes	the
T22709	37604-37612	NN	denotes	interval
T22710	37590-37591	CD	denotes	2
T22711	37592-37595	NN	denotes	LOD
T22712	37591-37592	HYPH	denotes	-
T22713	37596-37603	NN	denotes	support
T22714	37612-37613	.	denotes	.
T22715	37613-37780	sentence	denotes	Two N2 males were selected to propagate the N3 generation; one heterozygous for QTL on MMU1 and 9 and the other heterozygous for QTL on MMU5, 8, 11 and 17 (Figure 1).
T22716	37614-37617	CD	denotes	Two
T22717	37621-37626	NNS	denotes	males
T22718	37618-37620	NN	denotes	N2
T22719	37632-37640	VBN	denotes	selected
T22720	37627-37631	VBD	denotes	were
T22721	37641-37643	TO	denotes	to
T22722	37644-37653	VB	denotes	propagate
T22723	37654-37657	DT	denotes	the
T22724	37661-37671	NN	denotes	generation
T22725	37658-37660	NN	denotes	N3
T22726	37671-37672	:	denotes	;
T22727	37673-37676	CD	denotes	one
T22728	37677-37689	JJ	denotes	heterozygous
T22729	37690-37693	IN	denotes	for
T22730	37694-37697	NN	denotes	QTL
T22731	37698-37700	IN	denotes	on
T22732	37701-37704	NN	denotes	MMU
T22733	37704-37705	CD	denotes	1
T22734	37706-37709	CC	denotes	and
T22735	37710-37711	CD	denotes	9
T22736	37712-37715	CC	denotes	and
T22737	37716-37719	DT	denotes	the
T22738	37720-37725	JJ	denotes	other
T22739	37726-37738	NN	denotes	heterozygous
T22740	37739-37742	IN	denotes	for
T22741	37743-37746	NN	denotes	QTL
T22742	37747-37749	IN	denotes	on
T22743	37750-37753	NN	denotes	MMU
T22744	37753-37754	CD	denotes	5
T22745	37754-37756	,	denotes	,
T22746	37756-37757	CD	denotes	8
T22747	37757-37759	,	denotes	,
T22748	37759-37761	CD	denotes	11
T22749	37762-37765	CC	denotes	and
T22750	37766-37768	CD	denotes	17
T22751	37769-37770	-LRB-	denotes	(
T22752	37770-37776	NN	denotes	Figure
T22753	37777-37778	CD	denotes	1
T22754	37778-37779	-RRB-	denotes	)
T22755	37779-37780	.	denotes	.
T22756	37780-37846	sentence	denotes	Both males were homozygous for HG alleles at all other known QTL.
T22757	37781-37785	DT	denotes	Both
T22758	37786-37791	NNS	denotes	males
T22759	37792-37796	VBD	denotes	were
T22760	37797-37807	JJ	denotes	homozygous
T22761	37808-37811	IN	denotes	for
T22762	37812-37814	NN	denotes	HG
T22763	37815-37822	NNS	denotes	alleles
T22764	37823-37825	IN	denotes	at
T22765	37826-37829	DT	denotes	all
T22766	37842-37845	NN	denotes	QTL
T22767	37830-37835	JJ	denotes	other
T22768	37836-37841	VBN	denotes	known
T22769	37845-37846	.	denotes	.
T22770	37846-37997	sentence	denotes	These males were backcrossed to HG females and two of the resulting N3 males inheriting the same sets of QTL as their sire were selected for breeding.
T22771	37847-37852	DT	denotes	These
T22772	37853-37858	NNS	denotes	males
T22773	37864-37875	VBN	denotes	backcrossed
T22774	37859-37863	VBD	denotes	were
T22775	37876-37878	IN	denotes	to
T22776	37879-37881	NN	denotes	HG
T22777	37882-37889	NNS	denotes	females
T22778	37890-37893	CC	denotes	and
T22779	37894-37897	CD	denotes	two
T22780	37975-37983	VBN	denotes	selected
T22781	37898-37900	IN	denotes	of
T22782	37901-37904	DT	denotes	the
T22783	37918-37923	NNS	denotes	males
T22784	37905-37914	VBG	denotes	resulting
T22785	37915-37917	NN	denotes	N3
T22786	37924-37934	VBG	denotes	inheriting
T22787	37935-37938	DT	denotes	the
T22788	37944-37948	NNS	denotes	sets
T22789	37939-37943	JJ	denotes	same
T22790	37949-37951	IN	denotes	of
T22791	37952-37955	NN	denotes	QTL
T22792	37956-37958	IN	denotes	as
T22793	37959-37964	PRP$	denotes	their
T22794	37965-37969	NN	denotes	sire
T22795	37970-37974	VBD	denotes	were
T22796	37984-37987	IN	denotes	for
T22797	37988-37996	NN	denotes	breeding
T22798	37996-37997	.	denotes	.
T22799	37997-38190	sentence	denotes	These males were subsequently backcrossed to HG females and three N4 males were identified heterozygous for the following regions: 1) MMU1 and 9; 2) MMU5 and 11; 3) MMU8, 11 and 17 (Figure 1).
T22800	37998-38003	DT	denotes	These
T22801	38004-38009	NNS	denotes	males
T22802	38028-38039	VBN	denotes	backcrossed
T22803	38010-38014	VBD	denotes	were
T22804	38015-38027	RB	denotes	subsequently
T22805	38040-38042	IN	denotes	to
T22806	38043-38045	NN	denotes	HG
T22807	38046-38053	NNS	denotes	females
T22808	38054-38057	CC	denotes	and
T22809	38058-38063	CD	denotes	three
T22810	38067-38072	NNS	denotes	males
T22811	38064-38066	NN	denotes	N4
T22812	38078-38088	VBN	denotes	identified
T22813	38073-38077	VBD	denotes	were
T22814	38089-38101	JJ	denotes	heterozygous
T22815	38102-38105	IN	denotes	for
T22816	38106-38109	DT	denotes	the
T22817	38120-38127	NNS	denotes	regions
T22818	38110-38119	VBG	denotes	following
T22819	38127-38129	:	denotes	:
T22820	38129-38130	LS	denotes	1
T22821	38135-38136	CD	denotes	1
T22822	38130-38131	-RRB-	denotes	)
T22823	38132-38135	NN	denotes	MMU
T22824	38137-38140	CC	denotes	and
T22825	38141-38142	CD	denotes	9
T22826	38142-38143	:	denotes	;
T22827	38144-38145	LS	denotes	2
T22828	38150-38151	CD	denotes	5
T22829	38145-38146	-RRB-	denotes	)
T22830	38147-38150	NN	denotes	MMU
T22831	38152-38155	CC	denotes	and
T22832	38156-38158	CD	denotes	11
T22833	38158-38159	:	denotes	;
T22834	38160-38161	LS	denotes	3
T22835	38166-38167	CD	denotes	8
T22836	38161-38162	-RRB-	denotes	)
T22837	38163-38166	NN	denotes	MMU
T22838	38167-38169	,	denotes	,
T22839	38169-38171	CD	denotes	11
T22840	38172-38175	CC	denotes	and
T22841	38176-38178	CD	denotes	17
T22842	38179-38180	-LRB-	denotes	(
T22843	38180-38186	NN	denotes	Figure
T22844	38187-38188	CD	denotes	1
T22845	38188-38189	-RRB-	denotes	)
T22846	38189-38190	.	denotes	.
T22847	38190-38497	sentence	denotes	Starting at N4 and continuing through N6, the "best" male with the lowest percent of unwanted donor alleles was selected after performing a genome scan using the remaining 67 genome-wide markers (79 total markers minus the 12 markers genotyped in the first two backcrosses spanning the know QTL intervals).
T22848	38191-38199	VBG	denotes	Starting
T22849	38303-38311	VBN	denotes	selected
T22850	38200-38202	IN	denotes	at
T22851	38203-38205	NN	denotes	N4
T22852	38206-38209	CC	denotes	and
T22856	38231-38233	,	denotes	,
T22857	38233-38236	DT	denotes	the
T22858	38244-38248	JJ	denotes	male
T22859	38237-38238	``	denotes	"
T22860	38238-38242	JJS	denotes	best
T22861	38242-38243	''	denotes	"
T22862	38249-38253	IN	denotes	with
T22863	38254-38257	DT	denotes	the
T22864	38265-38272	NN	denotes	percent
T22865	38258-38264	JJS	denotes	lowest
T22866	38273-38275	IN	denotes	of
T22867	38276-38284	JJ	denotes	unwanted
T22868	38291-38298	NNS	denotes	alleles
T22869	38285-38290	NN	denotes	donor
T22870	38299-38302	VBD	denotes	was
T22871	38312-38317	IN	denotes	after
T22872	38318-38328	VBG	denotes	performing
T22873	38329-38330	DT	denotes	a
T22874	38338-38342	NN	denotes	scan
T22875	38331-38337	NN	denotes	genome
T22876	38343-38348	VBG	denotes	using
T22877	38349-38352	DT	denotes	the
T22878	38378-38385	NNS	denotes	markers
T22879	38353-38362	VBG	denotes	remaining
T22880	38363-38365	CD	denotes	67
T22881	38366-38372	NN	denotes	genome
T22882	38373-38377	JJ	denotes	wide
T22883	38372-38373	HYPH	denotes	-
T22884	38386-38387	-LRB-	denotes	(
T22885	38396-38403	NNS	denotes	markers
T22886	38387-38389	CD	denotes	79
T22887	38390-38395	JJ	denotes	total
T22888	38404-38409	CC	denotes	minus
T22889	38410-38413	DT	denotes	the
T22890	38417-38424	NNS	denotes	markers
T22891	38414-38416	CD	denotes	12
T22892	38425-38434	VBN	denotes	genotyped
T22893	38435-38437	IN	denotes	in
T22894	38438-38441	DT	denotes	the
T22895	38452-38463	NNS	denotes	backcrosses
T22896	38442-38447	JJ	denotes	first
T22897	38448-38451	CD	denotes	two
T22898	38464-38472	VBG	denotes	spanning
T22899	38473-38476	DT	denotes	the
T22900	38486-38495	NNS	denotes	intervals
T22901	38477-38481	JJ	denotes	know
T22902	38482-38485	NN	denotes	QTL
T22903	38495-38496	-RRB-	denotes	)
T22904	38496-38497	.	denotes	.
T22905	38497-38628	sentence	denotes	At N5 a distinct strain was created for each of the six individual donor regions and heterozygous mice were intermated (Figure 1).
T22906	38498-38500	IN	denotes	At
T22907	38526-38533	VBN	denotes	created
T22908	38501-38503	NN	denotes	N5
T22909	38504-38505	DT	denotes	a
T22910	38515-38521	NN	denotes	strain
T22911	38506-38514	JJ	denotes	distinct
T22912	38522-38525	VBD	denotes	was
T22913	38534-38537	IN	denotes	for
T22914	38538-38542	DT	denotes	each
T22915	38543-38545	IN	denotes	of
T22916	38546-38549	DT	denotes	the
T22917	38571-38578	NNS	denotes	regions
T22918	38550-38553	CD	denotes	six
T22919	38554-38564	JJ	denotes	individual
T22920	38565-38570	NN	denotes	donor
T22921	38579-38582	CC	denotes	and
T22922	38583-38595	JJ	denotes	heterozygous
T22923	38596-38600	NNS	denotes	mice
T22924	38606-38616	VBN	denotes	intermated
T22925	38601-38605	VBD	denotes	were
T22926	38617-38618	-LRB-	denotes	(
T22927	38618-38624	NN	denotes	Figure
T22928	38625-38626	CD	denotes	1
T22929	38626-38627	-RRB-	denotes	)
T22930	38627-38628	.	denotes	.
T22931	38628-38717	sentence	denotes	Homozygous HG.CAST speed congenic strains were maintained through brother-sister mating.
T22932	38629-38639	JJ	denotes	Homozygous
T22933	38663-38670	NNS	denotes	strains
T22934	38640-38647	NN	denotes	HG.CAST
T22935	38648-38653	NN	denotes	speed
T22936	38654-38662	JJ	denotes	congenic
T22937	38676-38686	VBN	denotes	maintained
T22938	38671-38675	VBD	denotes	were
T22939	38687-38694	IN	denotes	through
T22940	38695-38702	NN	denotes	brother
T22941	38703-38709	NN	denotes	sister
T22942	38702-38703	HYPH	denotes	-
T22943	38710-38716	NN	denotes	mating
T22944	38716-38717	.	denotes	.
T22945	38717-38882	sentence	denotes	Once each congenic was stabilized, 19 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T22946	38718-38722	IN	denotes	Once
T22947	38741-38751	VBN	denotes	stabilized
T22948	38723-38727	DT	denotes	each
T22949	38728-38736	JJ	denotes	congenic
T22950	38737-38740	VBD	denotes	was
T22951	38795-38799	VBN	denotes	used
T22952	38751-38753	,	denotes	,
T22953	38753-38755	CD	denotes	19
T22954	38782-38789	NNS	denotes	markers
T22955	38756-38766	JJ	denotes	additional
T22956	38767-38781	NN	denotes	microsatellite
T22957	38790-38794	VBD	denotes	were
T22958	38800-38802	TO	denotes	to
T22959	38803-38809	VB	denotes	refine
T22960	38810-38813	DT	denotes	the
T22961	38814-38822	NN	denotes	position
T22962	38823-38825	IN	denotes	of
T22963	38826-38830	DT	denotes	each
T22964	38856-38861	NN	denotes	point
T22965	38831-38839	JJ	denotes	congenic
T22966	38840-38851	JJ	denotes	recombinant
T22967	38852-38855	NN	denotes	end
T22968	38862-38863	-LRB-	denotes	(
T22969	38874-38878	NN	denotes	File
T22970	38863-38873	JJ	denotes	Additional
T22971	38879-38880	CD	denotes	2
T22972	38880-38881	-RRB-	denotes	)
T22973	38881-38882	.	denotes	.
T23420	38884-38895	NN	denotes	Development
T23421	38896-38898	IN	denotes	of
T23422	38899-38907	NN	denotes	B6.CASTC
T23423	38929-38936	NNS	denotes	strains
T23424	38908-38911	CC	denotes	and
T23425	38912-38920	NN	denotes	HG.CASTC
T23426	38921-38928	NN	denotes	control
T23427	38936-39259	sentence	denotes	HG is a strain in which the hg deletion has been introgressed onto a B6 background, therefore the only genetic differences between the strains would be the hg locus, tightly linked alleles from the outbred strain on which hg arose and contaminating alleles remaining after the nine backcrosses and fixed during inbreeding.
T23428	38937-38939	NN	denotes	HG
T23429	38940-38942	VBZ	denotes	is
T23430	39086-39088	VB	denotes	be
T23431	38943-38944	DT	denotes	a
T23432	38945-38951	NN	denotes	strain
T23433	38952-38954	IN	denotes	in
T23434	38986-38998	VBN	denotes	introgressed
T23435	38955-38960	WDT	denotes	which
T23436	38961-38964	DT	denotes	the
T23437	38968-38976	NN	denotes	deletion
T23438	38965-38967	NN	denotes	hg
T23439	38977-38980	VBZ	denotes	has
T23440	38981-38985	VBN	denotes	been
T23441	38999-39003	IN	denotes	onto
T23442	39004-39005	DT	denotes	a
T23443	39009-39019	NN	denotes	background
T23444	39006-39008	NN	denotes	B6
T23445	39019-39021	,	denotes	,
T23446	39021-39030	RB	denotes	therefore
T23447	39031-39034	DT	denotes	the
T23448	39048-39059	NNS	denotes	differences
T23449	39035-39039	JJ	denotes	only
T23450	39040-39047	JJ	denotes	genetic
T23451	39060-39067	IN	denotes	between
T23452	39068-39071	DT	denotes	the
T23453	39072-39079	NNS	denotes	strains
T23454	39080-39085	MD	denotes	would
T23455	39089-39092	DT	denotes	the
T23456	39096-39101	NN	denotes	locus
T23457	39093-39095	NN	denotes	hg
T23458	39101-39103	,	denotes	,
T23459	39103-39110	RB	denotes	tightly
T23460	39111-39117	VBN	denotes	linked
T23461	39118-39125	NNS	denotes	alleles
T23462	39126-39130	IN	denotes	from
T23463	39131-39134	DT	denotes	the
T23464	39143-39149	NN	denotes	strain
T23465	39135-39142	VBN	denotes	outbred
T23466	39150-39152	IN	denotes	on
T23467	39162-39167	VBD	denotes	arose
T23468	39153-39158	WDT	denotes	which
T23469	39159-39161	NN	denotes	hg
T23470	39168-39171	CC	denotes	and
T23471	39172-39185	VBG	denotes	contaminating
T23472	39186-39193	NNS	denotes	alleles
T23473	39194-39203	VBG	denotes	remaining
T23474	39204-39209	IN	denotes	after
T23475	39210-39213	DT	denotes	the
T23476	39219-39230	NNS	denotes	backcrosses
T23477	39214-39218	CD	denotes	nine
T23478	39231-39234	CC	denotes	and
T23479	39235-39240	VBN	denotes	fixed
T23480	39241-39247	IN	denotes	during
T23481	39248-39258	NN	denotes	inbreeding
T23482	39258-39259	.	denotes	.
T23483	39259-39473	sentence	denotes	Instead of using parental B6 and HG strains as controls for phenotypic comparisons with each speed congenic, we choose to develop independent control strains originating from the same cross as the congenic panels.
T23484	39260-39267	RB	denotes	Instead
T23485	39268-39270	IN	denotes	of
T23486	39372-39378	VBP	denotes	choose
T23487	39271-39276	VBG	denotes	using
T23488	39277-39285	JJ	denotes	parental
T23489	39296-39303	NNS	denotes	strains
T23490	39286-39288	NN	denotes	B6
T23491	39289-39292	CC	denotes	and
T23492	39293-39295	NN	denotes	HG
T23493	39304-39306	IN	denotes	as
T23494	39307-39315	NNS	denotes	controls
T23495	39316-39319	IN	denotes	for
T23496	39320-39330	JJ	denotes	phenotypic
T23497	39331-39342	NNS	denotes	comparisons
T23498	39343-39347	IN	denotes	with
T23499	39348-39352	DT	denotes	each
T23500	39353-39358	NN	denotes	speed
T23501	39359-39367	JJ	denotes	congenic
T23502	39367-39369	,	denotes	,
T23503	39369-39371	PRP	denotes	we
T23504	39379-39381	TO	denotes	to
T23505	39382-39389	VB	denotes	develop
T23506	39390-39401	JJ	denotes	independent
T23507	39410-39417	NNS	denotes	strains
T23508	39402-39409	NN	denotes	control
T23509	39418-39429	VBG	denotes	originating
T23510	39430-39434	IN	denotes	from
T23511	39435-39438	DT	denotes	the
T23512	39444-39449	NN	denotes	cross
T23513	39439-39443	JJ	denotes	same
T23514	39450-39452	IN	denotes	as
T23515	39453-39456	DT	denotes	the
T23516	39466-39472	NNS	denotes	panels
T23517	39457-39465	JJ	denotes	congenic
T23518	39472-39473	.	denotes	.
T23519	39473-39590	sentence	denotes	Separate B6.CAST control (B6C) and HG.CAST control (HGC) strains were developed using mice from the MMU2 experiment.
T23520	39474-39482	JJ	denotes	Separate
T23521	39531-39538	NNS	denotes	strains
T23522	39483-39490	NN	denotes	B6.CAST
T23523	39491-39498	NN	denotes	control
T23524	39499-39500	-LRB-	denotes	(
T23525	39500-39503	NN	denotes	B6C
T23526	39503-39504	-RRB-	denotes	)
T23527	39505-39508	CC	denotes	and
T23528	39509-39516	NN	denotes	HG.CAST
T23529	39517-39524	NN	denotes	control
T23530	39525-39526	-LRB-	denotes	(
T23531	39526-39529	NN	denotes	HGC
T23532	39529-39530	-RRB-	denotes	)
T23533	39544-39553	VBN	denotes	developed
T23534	39539-39543	VBD	denotes	were
T23535	39554-39559	VBG	denotes	using
T23536	39560-39564	NNS	denotes	mice
T23537	39565-39569	IN	denotes	from
T23538	39570-39573	DT	denotes	the
T23539	39579-39589	NN	denotes	experiment
T23540	39574-39578	NN	denotes	MMU2
T23541	39589-39590	.	denotes	.
T23542	39590-39738	sentence	denotes	Mice from the last backcross inheriting only B6 or HG MMU2 alleles at markers spanning MMU2 were intermated to serve as the basis for each control.
T23543	39591-39595	NNS	denotes	Mice
T23544	39688-39698	VBN	denotes	intermated
T23545	39596-39600	IN	denotes	from
T23546	39601-39604	DT	denotes	the
T23547	39610-39619	NN	denotes	backcross
T23548	39605-39609	JJ	denotes	last
T23549	39620-39630	VBG	denotes	inheriting
T23550	39631-39635	RB	denotes	only
T23551	39650-39657	NNS	denotes	alleles
T23552	39636-39638	NN	denotes	B6
T23553	39639-39641	CC	denotes	or
T23554	39642-39644	NN	denotes	HG
T23555	39645-39649	NN	denotes	MMU2
T23556	39658-39660	IN	denotes	at
T23557	39661-39668	NNS	denotes	markers
T23558	39669-39677	VBG	denotes	spanning
T23559	39678-39682	NN	denotes	MMU2
T23560	39683-39687	VBD	denotes	were
T23561	39699-39701	TO	denotes	to
T23562	39702-39707	VB	denotes	serve
T23563	39708-39710	IN	denotes	as
T23564	39711-39714	DT	denotes	the
T23565	39715-39720	NN	denotes	basis
T23566	39721-39724	IN	denotes	for
T23567	39725-39729	DT	denotes	each
T23568	39730-39737	NN	denotes	control
T23569	39737-39738	.	denotes	.
T23570	39738-39819	sentence	denotes	Both control strains were subsequently maintained through brother-sister mating.
T23571	39739-39743	DT	denotes	Both
T23572	39752-39759	NNS	denotes	strains
T23573	39744-39751	NN	denotes	control
T23574	39778-39788	VBN	denotes	maintained
T23575	39760-39764	VBD	denotes	were
T23576	39765-39777	RB	denotes	subsequently
T23577	39789-39796	IN	denotes	through
T23578	39797-39804	NN	denotes	brother
T23579	39805-39811	NN	denotes	sister
T23580	39804-39805	HYPH	denotes	-
T23581	39812-39818	NN	denotes	mating
T23582	39818-39819	.	denotes	.
T23583	39819-40043	sentence	denotes	The control strains were coisogenic with the parental B6 or HG strain with the exception of mutations that arose during congenic construction and a small percentage of contaminating donor alleles missed after 6 backcrosses.
T23584	39820-39823	DT	denotes	The
T23585	39832-39839	NNS	denotes	strains
T23586	39824-39831	NN	denotes	control
T23587	39840-39844	VBD	denotes	were
T23588	39845-39855	JJ	denotes	coisogenic
T23589	39856-39860	IN	denotes	with
T23590	39861-39864	DT	denotes	the
T23591	39883-39889	NN	denotes	strain
T23592	39865-39873	JJ	denotes	parental
T23593	39874-39876	NN	denotes	B6
T23594	39877-39879	CC	denotes	or
T23595	39880-39882	NN	denotes	HG
T23596	39890-39894	IN	denotes	with
T23597	39895-39898	DT	denotes	the
T23598	39899-39908	NN	denotes	exception
T23599	39909-39911	IN	denotes	of
T23600	39912-39921	NNS	denotes	mutations
T23601	39922-39926	WDT	denotes	that
T23602	39927-39932	VBD	denotes	arose
T23603	39933-39939	IN	denotes	during
T23604	39940-39948	JJ	denotes	congenic
T23605	39949-39961	NN	denotes	construction
T23606	39962-39965	CC	denotes	and
T23607	39966-39967	DT	denotes	a
T23608	39974-39984	NN	denotes	percentage
T23609	39968-39973	JJ	denotes	small
T23610	39985-39987	IN	denotes	of
T23611	39988-40001	VBG	denotes	contaminating
T23612	40008-40015	NNS	denotes	alleles
T23613	40002-40007	NN	denotes	donor
T23614	40016-40022	VBN	denotes	missed
T23615	40023-40028	IN	denotes	after
T23616	40029-40030	CD	denotes	6
T23617	40031-40042	NNS	denotes	backcrosses
T23618	40042-40043	.	denotes	.
T23619	40043-40262	sentence	denotes	Therefore, since the congenics and controls were developed through the same selection scheme and possibly share common contaminating regions, the B6C and HGC strains are the most ideal control to compare each congenic.
T23620	40044-40053	RB	denotes	Therefore
T23621	40210-40213	VBP	denotes	are
T23622	40053-40055	,	denotes	,
T23623	40055-40060	IN	denotes	since
T23624	40093-40102	VBN	denotes	developed
T23625	40061-40064	DT	denotes	the
T23626	40065-40074	NNS	denotes	congenics
T23627	40075-40078	CC	denotes	and
T23628	40079-40087	NNS	denotes	controls
T23629	40088-40092	VBD	denotes	were
T23630	40103-40110	IN	denotes	through
T23631	40111-40114	DT	denotes	the
T23632	40130-40136	NN	denotes	scheme
T23633	40115-40119	JJ	denotes	same
T23634	40120-40129	NN	denotes	selection
T23635	40137-40140	CC	denotes	and
T23636	40141-40149	RB	denotes	possibly
T23637	40150-40155	VBP	denotes	share
T23638	40156-40162	JJ	denotes	common
T23639	40177-40184	NNS	denotes	regions
T23640	40163-40176	VBG	denotes	contaminating
T23641	40184-40186	,	denotes	,
T23642	40186-40189	DT	denotes	the
T23643	40202-40209	NNS	denotes	strains
T23644	40190-40193	NN	denotes	B6C
T23645	40194-40197	CC	denotes	and
T23646	40198-40201	NN	denotes	HGC
T23647	40214-40217	DT	denotes	the
T23648	40229-40236	NN	denotes	control
T23649	40218-40222	RBS	denotes	most
T23650	40223-40228	JJ	denotes	ideal
T23651	40237-40239	TO	denotes	to
T23652	40240-40247	VB	denotes	compare
T23653	40248-40252	DT	denotes	each
T23654	40253-40261	NN	denotes	congenic
T23655	40261-40262	.	denotes	.
T24427	40264-40274	JJ	denotes	Phenotypic
T24428	40275-40291	NN	denotes	characterization
T24429	40291-40398	sentence	denotes	Trait data were collected on approximately 40 mice (20 of each sex) from each congenic and control strain.
T24430	40292-40297	NN	denotes	Trait
T24431	40298-40302	NNS	denotes	data
T24432	40308-40317	VBN	denotes	collected
T24433	40303-40307	VBD	denotes	were
T24434	40318-40320	IN	denotes	on
T24435	40321-40334	RB	denotes	approximately
T24436	40335-40337	CD	denotes	40
T24437	40338-40342	NNS	denotes	mice
T24438	40343-40344	-LRB-	denotes	(
T24439	40344-40346	CD	denotes	20
T24440	40347-40349	IN	denotes	of
T24441	40350-40354	DT	denotes	each
T24442	40355-40358	NN	denotes	sex
T24443	40358-40359	-RRB-	denotes	)
T24444	40360-40364	IN	denotes	from
T24445	40365-40369	DT	denotes	each
T24446	40391-40397	NN	denotes	strain
T24447	40370-40378	JJ	denotes	congenic
T24448	40379-40382	CC	denotes	and
T24449	40383-40390	NN	denotes	control
T24450	40397-40398	.	denotes	.
T24451	40398-40555	sentence	denotes	To eliminate parity and reduce litter size effects only progeny from uniparous dams were characterized and all litters were standardized to 5–7 pups/litter.
T24452	40399-40401	TO	denotes	To
T24453	40402-40411	VB	denotes	eliminate
T24454	40488-40501	VBN	denotes	characterized
T24455	40412-40418	NN	denotes	parity
T24456	40419-40422	CC	denotes	and
T24457	40423-40429	VB	denotes	reduce
T24458	40430-40436	NN	denotes	litter
T24459	40437-40441	NN	denotes	size
T24460	40442-40449	NNS	denotes	effects
T24461	40450-40454	RB	denotes	only
T24462	40455-40462	NN	denotes	progeny
T24463	40463-40467	IN	denotes	from
T24464	40468-40477	JJ	denotes	uniparous
T24465	40478-40482	NNS	denotes	dams
T24466	40483-40487	VBD	denotes	were
T24467	40502-40505	CC	denotes	and
T24468	40506-40509	DT	denotes	all
T24469	40510-40517	NNS	denotes	litters
T24470	40523-40535	VBN	denotes	standardized
T24471	40518-40522	VBD	denotes	were
T24472	40536-40538	IN	denotes	to
T24473	40539-40540	CD	denotes	5
T24474	40541-40542	CD	denotes	7
T24475	40540-40541	SYM	denotes	–
T24476	40543-40547	NNS	denotes	pups
T24477	40547-40548	SYM	denotes	/
T24478	40548-40554	NN	denotes	litter
T24479	40554-40555	.	denotes	.
T24480	40555-40591	sentence	denotes	Mice were weaned at 3 weeks of age.
T24481	40556-40560	NNS	denotes	Mice
T24482	40566-40572	VBN	denotes	weaned
T24483	40561-40565	VBD	denotes	were
T24484	40573-40575	IN	denotes	at
T24485	40576-40577	CD	denotes	3
T24486	40578-40583	NNS	denotes	weeks
T24487	40584-40586	IN	denotes	of
T24488	40587-40590	NN	denotes	age
T24489	40590-40591	.	denotes	.
T24490	40591-40682	sentence	denotes	Feed (Purina 5008; 23.5% protein, 6.5% fat, 3.3 Kcal/g) and water were offered ad libitum.
T24491	40592-40596	NN	denotes	Feed
T24492	40663-40670	VBN	denotes	offered
T24493	40597-40598	-LRB-	denotes	(
T24494	40617-40624	NN	denotes	protein
T24495	40598-40604	NNP	denotes	Purina
T24496	40605-40609	CD	denotes	5008
T24497	40609-40610	:	denotes	;
T24498	40611-40615	CD	denotes	23.5
T24499	40615-40616	NN	denotes	%
T24500	40624-40626	,	denotes	,
T24501	40626-40629	CD	denotes	6.5
T24502	40629-40630	NN	denotes	%
T24503	40631-40634	NN	denotes	fat
T24504	40634-40636	,	denotes	,
T24505	40636-40639	CD	denotes	3.3
T24506	40640-40644	NN	denotes	Kcal
T24507	40644-40645	SYM	denotes	/
T24508	40645-40646	NN	denotes	g
T24509	40646-40647	-RRB-	denotes	)
T24510	40648-40651	CC	denotes	and
T24511	40652-40657	NN	denotes	water
T24512	40658-40662	VBD	denotes	were
T24513	40671-40673	FW	denotes	ad
T24514	40674-40681	FW	denotes	libitum
T24515	40681-40682	.	denotes	.
T24516	40682-40755	sentence	denotes	Mice were weighed to the nearest 0.1 g at 2WK, 3WK, 6WK, and 9WK of age.
T24517	40683-40687	NNS	denotes	Mice
T24518	40693-40700	VBN	denotes	weighed
T24519	40688-40692	VBD	denotes	were
T24520	40701-40703	IN	denotes	to
T24521	40704-40707	DT	denotes	the
T24522	40720-40721	NN	denotes	g
T24523	40708-40715	JJS	denotes	nearest
T24524	40716-40719	CD	denotes	0.1
T24525	40722-40724	IN	denotes	at
T24526	40725-40728	NN	denotes	2WK
T24527	40728-40730	,	denotes	,
T24528	40730-40733	NN	denotes	3WK
T24529	40733-40735	,	denotes	,
T24530	40735-40738	NN	denotes	6WK
T24531	40738-40740	,	denotes	,
T24532	40740-40743	CC	denotes	and
T24533	40744-40747	NN	denotes	9WK
T24534	40748-40750	IN	denotes	of
T24535	40751-40754	NN	denotes	age
T24536	40754-40755	.	denotes	.
T24537	40755-40894	sentence	denotes	At 9WK ( ± 5 days) mice were anesthetized under isoflurane and nasal-anal length (NA) and nasal-tail (NT) were measured to the nearest mm.
T24538	40756-40758	IN	denotes	At
T24539	40785-40797	VBN	denotes	anesthetized
T24540	40759-40762	NN	denotes	9WK
T24541	40763-40764	-LRB-	denotes	(
T24542	40765-40766	SYM	denotes	±
T24543	40767-40768	CD	denotes	5
T24544	40769-40773	NNS	denotes	days
T24545	40773-40774	-RRB-	denotes	)
T24546	40775-40779	NNS	denotes	mice
T24547	40780-40784	VBD	denotes	were
T24548	40798-40803	IN	denotes	under
T24549	40804-40814	NN	denotes	isoflurane
T24550	40815-40818	CC	denotes	and
T24551	40819-40824	JJ	denotes	nasal
T24552	40825-40829	JJ	denotes	anal
T24553	40824-40825	HYPH	denotes	-
T24554	40830-40836	NN	denotes	length
T24555	40867-40875	VBN	denotes	measured
T24556	40837-40838	-LRB-	denotes	(
T24557	40838-40840	NN	denotes	NA
T24558	40840-40841	-RRB-	denotes	)
T24559	40842-40845	CC	denotes	and
T24560	40846-40851	JJ	denotes	nasal
T24561	40852-40856	NN	denotes	tail
T24562	40851-40852	HYPH	denotes	-
T24563	40857-40858	-LRB-	denotes	(
T24564	40858-40860	NN	denotes	NT
T24565	40860-40861	-RRB-	denotes	)
T24566	40862-40866	VBD	denotes	were
T24567	40876-40878	IN	denotes	to
T24568	40879-40882	DT	denotes	the
T24569	40891-40893	NN	denotes	mm
T24570	40883-40890	JJS	denotes	nearest
T24571	40893-40894	.	denotes	.
T24572	40894-40937	sentence	denotes	Tail length was calculated as NA minus NT.
T24573	40895-40899	NN	denotes	Tail
T24574	40900-40906	NN	denotes	length
T24575	40911-40921	VBN	denotes	calculated
T24576	40907-40910	VBD	denotes	was
T24577	40922-40924	IN	denotes	as
T24578	40925-40927	NN	denotes	NA
T24579	40928-40933	CC	denotes	minus
T24580	40934-40936	NN	denotes	NT
T24581	40936-40937	.	denotes	.
T24582	40937-41011	sentence	denotes	Anesthetized mice were then sacrificed by decapitation and exsanguinated.
T24583	40938-40950	VBN	denotes	Anesthetized
T24584	40951-40955	NNS	denotes	mice
T24585	40966-40976	VBN	denotes	sacrificed
T24586	40956-40960	VBD	denotes	were
T24587	40961-40965	RB	denotes	then
T24588	40977-40979	IN	denotes	by
T24589	40980-40992	NN	denotes	decapitation
T24590	40993-40996	CC	denotes	and
T24591	40997-41010	VBN	denotes	exsanguinated
T24592	41010-41011	.	denotes	.
T24593	41011-41160	sentence	denotes	Femoral fat pad (FFP), gonadal fat pad (GFP), mesenteric fat pad (MFP) and retroperitoneal fat pad (RFP) were removed and weighed to the nearest mg.
T24594	41012-41019	JJ	denotes	Femoral
T24595	41024-41027	NN	denotes	pad
T24596	41020-41023	NN	denotes	fat
T24597	41122-41129	VBN	denotes	removed
T24598	41028-41029	-LRB-	denotes	(
T24599	41029-41032	NN	denotes	FFP
T24600	41032-41033	-RRB-	denotes	)
T24601	41033-41035	,	denotes	,
T24602	41035-41042	JJ	denotes	gonadal
T24603	41047-41050	NN	denotes	pad
T24604	41043-41046	NN	denotes	fat
T24605	41051-41052	-LRB-	denotes	(
T24606	41052-41055	NN	denotes	GFP
T24607	41055-41056	-RRB-	denotes	)
T24608	41056-41058	,	denotes	,
T24609	41058-41068	JJ	denotes	mesenteric
T24610	41073-41076	NN	denotes	pad
T24611	41069-41072	NN	denotes	fat
T24612	41077-41078	-LRB-	denotes	(
T24613	41078-41081	NN	denotes	MFP
T24614	41081-41082	-RRB-	denotes	)
T24615	41083-41086	CC	denotes	and
T24616	41087-41102	JJ	denotes	retroperitoneal
T24617	41107-41110	NN	denotes	pad
T24618	41103-41106	NN	denotes	fat
T24619	41111-41112	-LRB-	denotes	(
T24620	41112-41115	NN	denotes	RFP
T24621	41115-41116	-RRB-	denotes	)
T24622	41117-41121	VBD	denotes	were
T24623	41130-41133	CC	denotes	and
T24624	41134-41141	VBN	denotes	weighed
T24625	41142-41144	IN	denotes	to
T24626	41145-41148	DT	denotes	the
T24627	41157-41159	NN	denotes	mg
T24628	41149-41156	JJS	denotes	nearest
T24629	41159-41160	.	denotes	.
T24630	41160-41295	sentence	denotes	Chemical compositional analysis was performed for HGC, HG11 and HG17 carcasses as previously described with slight modifications [24].
T24631	41161-41169	JJ	denotes	Chemical
T24632	41184-41192	NN	denotes	analysis
T24633	41170-41183	JJ	denotes	compositional
T24634	41197-41206	VBN	denotes	performed
T24635	41193-41196	VBD	denotes	was
T24636	41207-41210	IN	denotes	for
T24637	41211-41214	NN	denotes	HGC
T24638	41230-41239	NNS	denotes	carcasses
T24639	41214-41216	,	denotes	,
T24640	41216-41220	NN	denotes	HG11
T24641	41221-41224	CC	denotes	and
T24642	41225-41229	NN	denotes	HG17
T24643	41240-41242	IN	denotes	as
T24644	41254-41263	VBN	denotes	described
T24645	41243-41253	RB	denotes	previously
T24646	41264-41268	IN	denotes	with
T24647	41269-41275	JJ	denotes	slight
T24648	41276-41289	NNS	denotes	modifications
T24649	41290-41291	-LRB-	denotes	[
T24650	41291-41293	CD	denotes	24
T24651	41293-41294	-RRB-	denotes	]
T24652	41294-41295	.	denotes	.
T24653	41295-41361	sentence	denotes	Briefly, after weighing each fat pad was returned to the carcass.
T24654	41296-41303	RB	denotes	Briefly
T24655	41337-41345	VBN	denotes	returned
T24656	41303-41305	,	denotes	,
T24657	41305-41310	IN	denotes	after
T24658	41311-41319	VBG	denotes	weighing
T24659	41320-41324	DT	denotes	each
T24660	41329-41332	NN	denotes	pad
T24661	41325-41328	NN	denotes	fat
T24662	41333-41336	VBD	denotes	was
T24663	41346-41348	IN	denotes	to
T24664	41349-41352	DT	denotes	the
T24665	41353-41360	NN	denotes	carcass
T24666	41360-41361	.	denotes	.
T24667	41361-41459	sentence	denotes	The entire gastrointestinal (GI) tract was subsequently removed and carcasses were again weighed.
T24668	41362-41365	DT	denotes	The
T24669	41395-41400	NN	denotes	tract
T24670	41366-41372	JJ	denotes	entire
T24671	41373-41389	JJ	denotes	gastrointestinal
T24672	41390-41391	-LRB-	denotes	(
T24673	41391-41393	NN	denotes	GI
T24674	41393-41394	-RRB-	denotes	)
T24675	41418-41425	VBN	denotes	removed
T24676	41401-41404	VBD	denotes	was
T24677	41405-41417	RB	denotes	subsequently
T24678	41426-41429	CC	denotes	and
T24679	41430-41439	NNS	denotes	carcasses
T24680	41451-41458	VBN	denotes	weighed
T24681	41440-41444	VBD	denotes	were
T24682	41445-41450	RB	denotes	again
T24683	41458-41459	.	denotes	.
T24684	41459-41508	sentence	denotes	This represented the empty carcass weight (ECW).
T24685	41460-41464	DT	denotes	This
T24686	41465-41476	VBD	denotes	represented
T24687	41477-41480	DT	denotes	the
T24688	41495-41501	NN	denotes	weight
T24689	41481-41486	JJ	denotes	empty
T24690	41487-41494	NN	denotes	carcass
T24691	41502-41503	-LRB-	denotes	(
T24692	41503-41506	NN	denotes	ECW
T24693	41506-41507	-RRB-	denotes	)
T24694	41507-41508	.	denotes	.
T24695	41508-41617	sentence	denotes	Carcasses were labeled and secured in two layers of cheesecloth (Fisher) and frozen at -20°C until analysis.
T24696	41509-41518	NNS	denotes	Carcasses
T24697	41524-41531	VBN	denotes	labeled
T24698	41519-41523	VBD	denotes	were
T24699	41532-41535	CC	denotes	and
T24700	41536-41543	VBN	denotes	secured
T24701	41544-41546	IN	denotes	in
T24702	41547-41550	CD	denotes	two
T24703	41551-41557	NNS	denotes	layers
T24704	41558-41560	IN	denotes	of
T24705	41561-41572	NN	denotes	cheesecloth
T24706	41573-41574	-LRB-	denotes	(
T24707	41574-41580	NNP	denotes	Fisher
T24708	41580-41581	-RRB-	denotes	)
T24709	41582-41585	CC	denotes	and
T24710	41586-41592	VBN	denotes	frozen
T24711	41593-41595	IN	denotes	at
T24712	41596-41597	SYM	denotes	-
T24713	41597-41599	CD	denotes	20
T24714	41599-41601	NN	denotes	°C
T24715	41602-41607	IN	denotes	until
T24716	41608-41616	NN	denotes	analysis
T24717	41616-41617	.	denotes	.
T24718	41617-41756	sentence	denotes	At this time, carcasses were freeze-dried for seven days and water content was determined by subtracting the freeze-dried weight from ECW.
T24719	41618-41620	IN	denotes	At
T24720	41654-41659	VBN	denotes	dried
T24721	41621-41625	DT	denotes	this
T24722	41626-41630	NN	denotes	time
T24723	41630-41632	,	denotes	,
T24724	41632-41641	NNS	denotes	carcasses
T24725	41642-41646	VBD	denotes	were
T24726	41647-41653	NN	denotes	freeze
T24727	41653-41654	HYPH	denotes	-
T24728	41660-41663	IN	denotes	for
T24729	41664-41669	CD	denotes	seven
T24730	41670-41674	NNS	denotes	days
T24731	41675-41678	CC	denotes	and
T24732	41679-41684	NN	denotes	water
T24733	41685-41692	NN	denotes	content
T24734	41697-41707	VBN	denotes	determined
T24735	41693-41696	VBD	denotes	was
T24736	41708-41710	IN	denotes	by
T24737	41711-41722	VBG	denotes	subtracting
T24738	41723-41726	DT	denotes	the
T24739	41740-41746	NN	denotes	weight
T24740	41727-41733	NN	denotes	freeze
T24741	41734-41739	VBN	denotes	dried
T24742	41733-41734	HYPH	denotes	-
T24743	41747-41751	IN	denotes	from
T24744	41752-41755	NNP	denotes	ECW
T24745	41755-41756	.	denotes	.
T24746	41756-41871	sentence	denotes	FAT was then extracted with ether for 7 days, followed by acetone for an additional 7 days in a Soxhlet apparatus.
T24747	41757-41760	NN	denotes	FAT
T24748	41803-41811	VBN	denotes	followed
T24749	41761-41764	VBD	denotes	was
T24750	41765-41769	RB	denotes	then
T24751	41770-41779	VBN	denotes	extracted
T24752	41780-41784	IN	denotes	with
T24753	41785-41790	NN	denotes	ether
T24754	41791-41794	IN	denotes	for
T24755	41795-41796	CD	denotes	7
T24756	41797-41801	NNS	denotes	days
T24757	41801-41803	,	denotes	,
T24758	41812-41814	IN	denotes	by
T24759	41815-41822	NN	denotes	acetone
T24760	41823-41826	IN	denotes	for
T24761	41827-41829	DT	denotes	an
T24762	41843-41847	NNS	denotes	days
T24763	41830-41840	JJ	denotes	additional
T24764	41841-41842	CD	denotes	7
T24765	41848-41850	IN	denotes	in
T24766	41851-41852	DT	denotes	a
T24767	41861-41870	NN	denotes	apparatus
T24768	41853-41860	NNP	denotes	Soxhlet
T24769	41870-41871	.	denotes	.
T24770	41871-41965	sentence	denotes	Carcass ash (ASH) was determined measuring the remains after a 16 hour incineration at 575°C.
T24771	41872-41879	NN	denotes	Carcass
T24772	41880-41883	NN	denotes	ash
T24773	41894-41904	VBN	denotes	determined
T24774	41884-41885	-LRB-	denotes	(
T24775	41885-41888	NN	denotes	ASH
T24776	41888-41889	-RRB-	denotes	)
T24777	41890-41893	VBD	denotes	was
T24778	41905-41914	VBG	denotes	measuring
T24779	41915-41918	DT	denotes	the
T24780	41919-41926	NNS	denotes	remains
T24781	41927-41932	IN	denotes	after
T24782	41933-41934	DT	denotes	a
T24783	41943-41955	NN	denotes	incineration
T24784	41935-41937	CD	denotes	16
T24785	41938-41942	NN	denotes	hour
T24786	41956-41958	IN	denotes	at
T24787	41959-41962	CD	denotes	575
T24788	41962-41964	NN	denotes	°C
T24789	41964-41965	.	denotes	.
T24790	41965-42086	sentence	denotes	Carcass protein (PROT) was calculated as the remaining portion after carcass fat (FAT) and ASH were subtracted from ECW.
T24791	41966-41973	NN	denotes	Carcass
T24792	41974-41981	NN	denotes	protein
T24793	41993-42003	VBN	denotes	calculated
T24794	41982-41983	-LRB-	denotes	(
T24795	41983-41987	NN	denotes	PROT
T24796	41987-41988	-RRB-	denotes	)
T24797	41989-41992	VBD	denotes	was
T24798	42004-42006	IN	denotes	as
T24799	42007-42010	DT	denotes	the
T24800	42021-42028	NN	denotes	portion
T24801	42011-42020	VBG	denotes	remaining
T24802	42029-42034	IN	denotes	after
T24803	42066-42076	VBN	denotes	subtracted
T24804	42035-42042	NN	denotes	carcass
T24805	42043-42046	NN	denotes	fat
T24806	42047-42048	-LRB-	denotes	(
T24807	42048-42051	NN	denotes	FAT
T24808	42051-42052	-RRB-	denotes	)
T24809	42053-42056	CC	denotes	and
T24810	42057-42060	NN	denotes	ASH
T24811	42061-42065	VBD	denotes	were
T24812	42077-42081	IN	denotes	from
T24813	42082-42085	NN	denotes	ECW
T24814	42085-42086	.	denotes	.
T25106	42088-42099	JJ	denotes	Statistical
T25107	42100-42108	NN	denotes	analysis
T25108	42108-42248	sentence	denotes	The MEANS and UNIVARIATE procedures of SAS were used to generate descriptive statistics and test normality assumptions for each trait [55].
T25109	42109-42112	DT	denotes	The
T25110	42134-42144	NNS	denotes	procedures
T25111	42113-42118	NN	denotes	MEANS
T25112	42119-42122	CC	denotes	and
T25113	42123-42133	NN	denotes	UNIVARIATE
T25114	42157-42161	VBN	denotes	used
T25115	42145-42147	IN	denotes	of
T25116	42148-42151	NNP	denotes	SAS
T25117	42152-42156	VBD	denotes	were
T25118	42162-42164	TO	denotes	to
T25119	42165-42173	VB	denotes	generate
T25120	42174-42185	JJ	denotes	descriptive
T25121	42186-42196	NNS	denotes	statistics
T25122	42197-42200	CC	denotes	and
T25123	42201-42205	VB	denotes	test
T25124	42206-42215	NN	denotes	normality
T25125	42216-42227	NNS	denotes	assumptions
T25126	42228-42231	IN	denotes	for
T25127	42232-42236	DT	denotes	each
T25128	42237-42242	NN	denotes	trait
T25129	42243-42244	-LRB-	denotes	[
T25130	42244-42246	CD	denotes	55
T25131	42246-42247	-RRB-	denotes	]
T25132	42247-42248	.	denotes	.
T25133	42248-42470	sentence	denotes	All data were then analyzed using the GLM procedure of SAS [55] with a linear model that included the fixed effects of strain, sex and strain by sex interaction; dam's weight at breeding by strain was used as a covariate.
T25134	42249-42252	DT	denotes	All
T25135	42253-42257	NNS	denotes	data
T25136	42268-42276	VBN	denotes	analyzed
T25137	42258-42262	VBD	denotes	were
T25138	42263-42267	RB	denotes	then
T25139	42450-42454	VBN	denotes	used
T25140	42277-42282	VBG	denotes	using
T25141	42283-42286	DT	denotes	the
T25142	42291-42300	NN	denotes	procedure
T25143	42287-42290	NN	denotes	GLM
T25144	42301-42303	IN	denotes	of
T25145	42304-42307	NN	denotes	SAS
T25146	42308-42309	-LRB-	denotes	[
T25147	42309-42311	CD	denotes	55
T25148	42311-42312	-RRB-	denotes	]
T25149	42313-42317	IN	denotes	with
T25150	42318-42319	DT	denotes	a
T25151	42327-42332	NN	denotes	model
T25152	42320-42326	JJ	denotes	linear
T25153	42333-42337	WDT	denotes	that
T25154	42338-42346	VBD	denotes	included
T25155	42347-42350	DT	denotes	the
T25156	42357-42364	NNS	denotes	effects
T25157	42351-42356	VBN	denotes	fixed
T25158	42365-42367	IN	denotes	of
T25159	42368-42374	NN	denotes	strain
T25160	42374-42376	,	denotes	,
T25161	42376-42379	NN	denotes	sex
T25162	42380-42383	CC	denotes	and
T25163	42384-42390	NN	denotes	strain
T25164	42398-42409	NN	denotes	interaction
T25165	42391-42393	IN	denotes	by
T25166	42394-42397	NN	denotes	sex
T25167	42409-42410	:	denotes	;
T25168	42411-42414	NN	denotes	dam
T25169	42417-42423	NN	denotes	weight
T25170	42414-42416	POS	denotes	's
T25171	42424-42426	IN	denotes	at
T25172	42427-42435	NN	denotes	breeding
T25173	42436-42438	IN	denotes	by
T25174	42439-42445	NN	denotes	strain
T25175	42446-42449	VBD	denotes	was
T25176	42455-42457	IN	denotes	as
T25177	42458-42459	DT	denotes	a
T25178	42460-42469	NN	denotes	covariate
T25179	42469-42470	.	denotes	.
T25180	42470-42564	sentence	denotes	A second linear model was used to test for strain by hg genotype (+/+ or hg/hg) interactions.
T25181	42471-42472	DT	denotes	A
T25182	42487-42492	NN	denotes	model
T25183	42473-42479	JJ	denotes	second
T25184	42480-42486	JJ	denotes	linear
T25185	42497-42501	VBN	denotes	used
T25186	42493-42496	VBD	denotes	was
T25187	42502-42504	TO	denotes	to
T25188	42505-42509	VB	denotes	test
T25189	42510-42513	IN	denotes	for
T25190	42514-42520	NN	denotes	strain
T25191	42551-42563	NNS	denotes	interactions
T25192	42521-42523	IN	denotes	by
T25193	42524-42526	NN	denotes	hg
T25194	42527-42535	NN	denotes	genotype
T25195	42536-42537	-LRB-	denotes	(
T25196	42539-42540	SYM	denotes	+
T25197	42537-42538	SYM	denotes	+
T25198	42538-42539	HYPH	denotes	/
T25199	42541-42543	CC	denotes	or
T25200	42544-42546	NN	denotes	hg
T25201	42547-42549	NN	denotes	hg
T25202	42546-42547	HYPH	denotes	/
T25203	42549-42550	-RRB-	denotes	)
T25204	42563-42564	.	denotes	.
T25205	42564-42688	sentence	denotes	This model included the fixed effects of donor region, sex and HG genotype and all possible two and three-way interactions.
T25206	42565-42569	DT	denotes	This
T25207	42570-42575	NN	denotes	model
T25208	42576-42584	VBD	denotes	included
T25209	42585-42588	DT	denotes	the
T25210	42595-42602	NNS	denotes	effects
T25211	42589-42594	VBN	denotes	fixed
T25212	42603-42605	IN	denotes	of
T25213	42606-42611	NN	denotes	donor
T25214	42612-42618	NN	denotes	region
T25215	42618-42620	,	denotes	,
T25216	42620-42623	NN	denotes	sex
T25217	42624-42627	CC	denotes	and
T25218	42628-42630	NN	denotes	HG
T25219	42631-42639	NN	denotes	genotype
T25220	42640-42643	CC	denotes	and
T25221	42644-42647	DT	denotes	all
T25222	42675-42687	NNS	denotes	interactions
T25223	42648-42656	JJ	denotes	possible
T25224	42657-42660	CD	denotes	two
T25225	42671-42674	NN	denotes	way
T25226	42661-42664	CC	denotes	and
T25227	42665-42670	CD	denotes	three
T25228	42670-42671	HYPH	denotes	-
T25229	42687-42688	.	denotes	.
T25230	42688-42839	sentence	denotes	Choosing a nominal P value of 0.05 and applying the Bonferroni correction for multiple comparisons established significant differences in the ANOVA's.
T25231	42689-42697	VBG	denotes	Choosing
T25232	42788-42799	VBD	denotes	established
T25233	42698-42699	DT	denotes	a
T25234	42710-42715	NN	denotes	value
T25235	42700-42707	JJ	denotes	nominal
T25236	42708-42709	NN	denotes	P
T25237	42716-42718	IN	denotes	of
T25238	42719-42723	CD	denotes	0.05
T25239	42724-42727	CC	denotes	and
T25240	42728-42736	VBG	denotes	applying
T25241	42737-42740	DT	denotes	the
T25242	42752-42762	NN	denotes	correction
T25243	42741-42751	NNP	denotes	Bonferroni
T25244	42763-42766	IN	denotes	for
T25245	42767-42775	JJ	denotes	multiple
T25246	42776-42787	NNS	denotes	comparisons
T25247	42800-42811	JJ	denotes	significant
T25248	42812-42823	NNS	denotes	differences
T25249	42824-42826	IN	denotes	in
T25250	42827-42830	DT	denotes	the
T25251	42831-42836	NNP	denotes	ANOVA
T25252	42836-42838	AFX	denotes	's
T25253	42838-42839	.	denotes	.
T25254	42839-42895	sentence	denotes	The critical P values used are indicated in each table.
T25255	42840-42843	DT	denotes	The
T25256	42855-42861	NNS	denotes	values
T25257	42844-42852	JJ	denotes	critical
T25258	42853-42854	NN	denotes	P
T25259	42871-42880	VBN	denotes	indicated
T25260	42862-42866	VBN	denotes	used
T25261	42867-42870	VBP	denotes	are
T25262	42881-42883	IN	denotes	in
T25263	42884-42888	DT	denotes	each
T25264	42889-42894	NN	denotes	table
T25265	42894-42895	.	denotes	.
T25440	42897-42911	NN	denotes	Identification
T25441	42912-42914	IN	denotes	of
T25442	42915-42924	NN	denotes	candidate
T25443	42925-42930	NNS	denotes	genes
T25444	42930-43024	sentence	denotes	Genes were identified by manual data mining of primary literature, reviews and book chapters.
T25445	42931-42936	NNS	denotes	Genes
T25446	42942-42952	VBN	denotes	identified
T25447	42937-42941	VBD	denotes	were
T25448	42953-42955	IN	denotes	by
T25449	42956-42962	JJ	denotes	manual
T25450	42968-42974	NN	denotes	mining
T25451	42963-42967	NNS	denotes	data
T25452	42975-42977	IN	denotes	of
T25453	42978-42985	JJ	denotes	primary
T25454	42986-42996	NN	denotes	literature
T25455	42996-42998	,	denotes	,
T25456	42998-43005	NNS	denotes	reviews
T25457	43006-43009	CC	denotes	and
T25458	43010-43014	NN	denotes	book
T25459	43015-43023	NNS	denotes	chapters
T25460	43023-43024	.	denotes	.
T25461	43024-43205	sentence	denotes	To organize and collate genomic and functional information for each gene we created a custom Gh signaling Gene Map Annotator and Pathway Profiler (GenMAPP) pathway [56] (Figure 5).
T25462	43025-43027	TO	denotes	To
T25463	43028-43036	VB	denotes	organize
T25464	43101-43108	VBD	denotes	created
T25465	43037-43040	CC	denotes	and
T25466	43041-43048	VB	denotes	collate
T25467	43049-43056	JJ	denotes	genomic
T25468	43072-43083	NN	denotes	information
T25469	43057-43060	CC	denotes	and
T25470	43061-43071	JJ	denotes	functional
T25471	43084-43087	IN	denotes	for
T25472	43088-43092	DT	denotes	each
T25473	43093-43097	NN	denotes	gene
T25474	43098-43100	PRP	denotes	we
T25475	43109-43110	DT	denotes	a
T25476	43140-43149	NN	denotes	Annotator
T25477	43111-43117	NN	denotes	custom
T25478	43118-43120	NN	denotes	Gh
T25479	43121-43130	NN	denotes	signaling
T25480	43131-43135	NN	denotes	Gene
T25481	43136-43139	NN	denotes	Map
T25482	43150-43153	CC	denotes	and
T25483	43154-43161	NN	denotes	Pathway
T25484	43162-43170	NN	denotes	Profiler
T25485	43181-43188	NN	denotes	pathway
T25486	43171-43172	-LRB-	denotes	(
T25487	43172-43179	NNP	denotes	GenMAPP
T25488	43179-43180	-RRB-	denotes	)
T25489	43189-43190	-LRB-	denotes	[
T25490	43190-43192	CD	denotes	56
T25491	43192-43193	-RRB-	denotes	]
T25492	43194-43195	-LRB-	denotes	(
T25493	43195-43201	NN	denotes	Figure
T25494	43202-43203	CD	denotes	5
T25495	43203-43204	-RRB-	denotes	)
T25496	43204-43205	.	denotes	.
T25497	43205-43348	sentence	denotes	Visualization and color-coding of genes using GenMAPP aided the selection of candidate genes mapping within QTL regions on MMU2, 9, 11 and 17.
T25498	43206-43219	NN	denotes	Visualization
T25499	43260-43265	VBD	denotes	aided
T25500	43220-43223	CC	denotes	and
T25501	43224-43229	NN	denotes	color
T25502	43229-43230	HYPH	denotes	-
T25503	43230-43236	VBG	denotes	coding
T25504	43237-43239	IN	denotes	of
T25505	43240-43245	NNS	denotes	genes
T25506	43246-43251	VBG	denotes	using
T25507	43252-43259	NNP	denotes	GenMAPP
T25508	43266-43269	DT	denotes	the
T25509	43270-43279	NN	denotes	selection
T25510	43280-43282	IN	denotes	of
T25511	43283-43292	NN	denotes	candidate
T25512	43293-43298	NNS	denotes	genes
T25513	43299-43306	VBG	denotes	mapping
T25514	43307-43313	IN	denotes	within
T25515	43314-43317	NNS	denotes	QTL
T25516	43318-43325	NNS	denotes	regions
T25517	43326-43328	IN	denotes	on
T25518	43329-43332	NN	denotes	MMU
T25519	43332-43333	CD	denotes	2
T25520	43333-43335	,	denotes	,
T25521	43335-43336	CD	denotes	9
T25522	43336-43338	,	denotes	,
T25523	43338-43340	CD	denotes	11
T25524	43341-43344	CC	denotes	and
T25525	43345-43347	CD	denotes	17
T25526	43347-43348	.	denotes	.
T26350	43350-43359	NN	denotes	Candidate
T26351	43360-43364	NN	denotes	gene
T26352	43365-43375	NN	denotes	sequencing
T26353	43375-43614	sentence	denotes	PCR amplicons covering the coding sequence and partial 5' and 3' untranslated regions for each selected candidate gene were amplified, purified and sequenced from the CAST strain using protocols outlined in [57] with slight modifications.
T26354	43376-43379	NN	denotes	PCR
T26355	43380-43389	NNS	denotes	amplicons
T26356	43500-43509	VBN	denotes	amplified
T26357	43390-43398	VBG	denotes	covering
T26358	43399-43402	DT	denotes	the
T26359	43410-43418	NN	denotes	sequence
T26360	43403-43409	NN	denotes	coding
T26361	43419-43422	CC	denotes	and
T26362	43423-43430	JJ	denotes	partial
T26363	43454-43461	NNS	denotes	regions
T26364	43431-43432	CD	denotes	5
T26365	43432-43433	SYM	denotes	'
T26366	43434-43437	CC	denotes	and
T26367	43438-43439	CD	denotes	3
T26368	43439-43440	SYM	denotes	'
T26369	43441-43453	JJ	denotes	untranslated
T26370	43462-43465	IN	denotes	for
T26371	43466-43470	DT	denotes	each
T26372	43490-43494	NN	denotes	gene
T26373	43471-43479	VBN	denotes	selected
T26374	43480-43489	NN	denotes	candidate
T26375	43495-43499	VBD	denotes	were
T26376	43509-43511	,	denotes	,
T26377	43511-43519	VBN	denotes	purified
T26378	43520-43523	CC	denotes	and
T26379	43524-43533	VBN	denotes	sequenced
T26380	43534-43538	IN	denotes	from
T26381	43539-43542	DT	denotes	the
T26382	43548-43554	NN	denotes	strain
T26383	43543-43547	NN	denotes	CAST
T26384	43555-43560	VBG	denotes	using
T26385	43561-43570	NNS	denotes	protocols
T26386	43571-43579	VBN	denotes	outlined
T26387	43580-43582	IN	denotes	in
T26388	43583-43584	-LRB-	denotes	[
T26389	43584-43586	CD	denotes	57
T26390	43586-43587	-RRB-	denotes	]
T26391	43588-43592	IN	denotes	with
T26392	43593-43599	JJ	denotes	slight
T26393	43600-43613	NNS	denotes	modifications
T26394	43613-43614	.	denotes	.
T26395	43614-43733	sentence	denotes	Total RNA from brain, liver, spleen, lung and testis was isolated from an adult CAST male mouse using Trizol (Ambion).
T26396	43615-43620	JJ	denotes	Total
T26397	43621-43624	NN	denotes	RNA
T26398	43672-43680	VBN	denotes	isolated
T26399	43625-43629	IN	denotes	from
T26400	43630-43635	NN	denotes	brain
T26401	43635-43637	,	denotes	,
T26402	43637-43642	NN	denotes	liver
T26403	43642-43644	,	denotes	,
T26404	43644-43650	NN	denotes	spleen
T26405	43650-43652	,	denotes	,
T26406	43652-43656	NN	denotes	lung
T26407	43657-43660	CC	denotes	and
T26408	43661-43667	NN	denotes	testis
T26409	43668-43671	VBD	denotes	was
T26410	43681-43685	IN	denotes	from
T26411	43686-43688	DT	denotes	an
T26412	43705-43710	NN	denotes	mouse
T26413	43689-43694	JJ	denotes	adult
T26414	43695-43699	NN	denotes	CAST
T26415	43700-43704	JJ	denotes	male
T26416	43711-43716	VBG	denotes	using
T26417	43717-43723	NN	denotes	Trizol
T26418	43724-43725	-LRB-	denotes	(
T26419	43725-43731	NNP	denotes	Ambion
T26420	43731-43732	-RRB-	denotes	)
T26421	43732-43733	.	denotes	.
T26422	43733-43793	sentence	denotes	cDNA was produced from total RNA using standard procedures.
T26423	43734-43738	NN	denotes	cDNA
T26424	43743-43751	VBN	denotes	produced
T26425	43739-43742	VBD	denotes	was
T26426	43752-43756	IN	denotes	from
T26427	43757-43762	JJ	denotes	total
T26428	43763-43766	NN	denotes	RNA
T26429	43767-43772	VBG	denotes	using
T26430	43773-43781	JJ	denotes	standard
T26431	43782-43792	NNS	denotes	procedures
T26432	43792-43793	.	denotes	.
T26433	43793-43877	sentence	denotes	PCR primer sets for each gene were designed using Primer3 [58] (Additional File 5).
T26434	43794-43797	NN	denotes	PCR
T26435	43805-43809	NNS	denotes	sets
T26436	43798-43804	NN	denotes	primer
T26437	43829-43837	VBN	denotes	designed
T26438	43810-43813	IN	denotes	for
T26439	43814-43818	DT	denotes	each
T26440	43819-43823	NN	denotes	gene
T26441	43824-43828	VBD	denotes	were
T26442	43838-43843	VBG	denotes	using
T26443	43844-43851	NN	denotes	Primer3
T26444	43852-43853	-LRB-	denotes	[
T26445	43853-43855	CD	denotes	58
T26446	43855-43856	-RRB-	denotes	]
T26447	43857-43858	-LRB-	denotes	(
T26448	43869-43873	NN	denotes	File
T26449	43858-43868	JJ	denotes	Additional
T26450	43874-43875	CD	denotes	5
T26451	43875-43876	-RRB-	denotes	)
T26452	43876-43877	.	denotes	.
T26453	43877-44013	sentence	denotes	The initial amplification was performed in 10 μl PCR reactions using the Invitrogen Platinum TaqPCRx amplification system (Invitrogen).
T26454	43878-43881	DT	denotes	The
T26455	43890-43903	NN	denotes	amplification
T26456	43882-43889	JJ	denotes	initial
T26457	43908-43917	VBN	denotes	performed
T26458	43904-43907	VBD	denotes	was
T26459	43918-43920	IN	denotes	in
T26460	43921-43923	CD	denotes	10
T26461	43924-43926	NN	denotes	μl
T26462	43931-43940	NNS	denotes	reactions
T26463	43927-43930	NN	denotes	PCR
T26464	43941-43946	VBG	denotes	using
T26465	43947-43950	DT	denotes	the
T26466	43993-43999	NN	denotes	system
T26467	43951-43961	NNP	denotes	Invitrogen
T26468	43962-43970	NN	denotes	Platinum
T26469	43971-43978	NN	denotes	TaqPCRx
T26470	43979-43992	NN	denotes	amplification
T26471	44000-44001	-LRB-	denotes	(
T26472	44001-44011	NNP	denotes	Invitrogen
T26473	44011-44012	-RRB-	denotes	)
T26474	44012-44013	.	denotes	.
T26475	44013-44192	sentence	denotes	The reactions contained 1X PCR buffer, 1X Enhancer solution, 1.5 mM MgSO4, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Platinum Taq (Invitrogen) and approximately 25 ng of cDNA.
T26476	44014-44017	DT	denotes	The
T26477	44018-44027	NNS	denotes	reactions
T26478	44028-44037	VBD	denotes	contained
T26479	44038-44040	NN	denotes	1X
T26480	44045-44051	NN	denotes	buffer
T26481	44041-44044	NN	denotes	PCR
T26482	44051-44053	,	denotes	,
T26483	44053-44055	NN	denotes	1X
T26484	44065-44073	NN	denotes	solution
T26485	44056-44064	NN	denotes	Enhancer
T26486	44073-44075	,	denotes	,
T26487	44075-44078	CD	denotes	1.5
T26488	44079-44081	NN	denotes	mM
T26489	44082-44087	NN	denotes	MgSO4
T26490	44087-44089	,	denotes	,
T26491	44089-44093	CD	denotes	0.17
T26492	44094-44096	NN	denotes	mM
T26493	44097-44102	NNS	denotes	dNTPs
T26494	44102-44104	,	denotes	,
T26495	44104-44105	CD	denotes	1
T26496	44106-44108	NN	denotes	μM
T26497	44114-44120	NN	denotes	primer
T26498	44109-44113	DT	denotes	each
T26499	44120-44122	,	denotes	,
T26500	44122-44125	CD	denotes	0.1
T26501	44126-44130	NN	denotes	unit
T26502	44131-44133	IN	denotes	of
T26503	44134-44142	NN	denotes	Platinum
T26504	44143-44146	NN	denotes	Taq
T26505	44147-44148	-LRB-	denotes	(
T26506	44148-44158	NNP	denotes	Invitrogen
T26507	44158-44159	-RRB-	denotes	)
T26508	44160-44163	CC	denotes	and
T26509	44164-44177	RB	denotes	approximately
T26510	44178-44180	CD	denotes	25
T26511	44181-44183	NN	denotes	ng
T26512	44184-44186	IN	denotes	of
T26513	44187-44191	NN	denotes	cDNA
T26514	44191-44192	.	denotes	.
T26515	44192-44373	sentence	denotes	Reactions were incubated for 5 min at 95°C, then cycled for 45 s at 95°C, 45 s at 55°C, 1 min at 72°C for 35 cycles with a final 72°C extension for 10 min on a MJ Research PTC-200.
T26516	44193-44202	NNS	denotes	Reactions
T26517	44208-44217	VBN	denotes	incubated
T26518	44203-44207	VBD	denotes	were
T26519	44218-44221	IN	denotes	for
T26520	44222-44223	CD	denotes	5
T26521	44224-44227	NN	denotes	min
T26522	44228-44230	IN	denotes	at
T26523	44231-44233	CD	denotes	95
T26524	44233-44235	NN	denotes	°C
T26525	44235-44237	,	denotes	,
T26526	44237-44241	RB	denotes	then
T26527	44242-44248	VBN	denotes	cycled
T26528	44249-44252	IN	denotes	for
T26529	44253-44255	CD	denotes	45
T26530	44256-44257	NN	denotes	s
T26531	44258-44260	IN	denotes	at
T26532	44261-44263	CD	denotes	95
T26533	44263-44265	NN	denotes	°C
T26534	44265-44267	,	denotes	,
T26535	44267-44269	CD	denotes	45
T26536	44270-44271	NN	denotes	s
T26537	44272-44274	IN	denotes	at
T26538	44275-44277	CD	denotes	55
T26539	44277-44279	NN	denotes	°C
T26540	44279-44281	,	denotes	,
T26541	44281-44282	CD	denotes	1
T26542	44283-44286	NN	denotes	min
T26543	44287-44289	IN	denotes	at
T26544	44290-44292	CD	denotes	72
T26545	44292-44294	NN	denotes	°C
T26546	44295-44298	IN	denotes	for
T26547	44299-44301	CD	denotes	35
T26548	44302-44308	NNS	denotes	cycles
T26549	44309-44313	IN	denotes	with
T26550	44314-44315	DT	denotes	a
T26551	44327-44336	NN	denotes	extension
T26552	44316-44321	JJ	denotes	final
T26553	44322-44324	CD	denotes	72
T26554	44324-44326	NN	denotes	°C
T26555	44337-44340	IN	denotes	for
T26556	44341-44343	CD	denotes	10
T26557	44344-44347	NN	denotes	min
T26558	44348-44350	IN	denotes	on
T26559	44351-44352	DT	denotes	a
T26560	44365-44368	NNP	denotes	PTC
T26561	44353-44355	NNP	denotes	MJ
T26562	44356-44364	NNP	denotes	Research
T26563	44368-44369	HYPH	denotes	-
T26564	44369-44372	CD	denotes	200
T26565	44372-44373	.	denotes	.
T26566	44373-44451	sentence	denotes	The products were visualized on 1.5% agarose gels containing 0.06 μg/ml EtBr.
T26567	44374-44377	DT	denotes	The
T26568	44378-44386	NNS	denotes	products
T26569	44392-44402	VBN	denotes	visualized
T26570	44387-44391	VBD	denotes	were
T26571	44403-44405	IN	denotes	on
T26572	44406-44409	CD	denotes	1.5
T26573	44409-44410	NN	denotes	%
T26574	44411-44418	NN	denotes	agarose
T26575	44419-44423	NNS	denotes	gels
T26576	44424-44434	VBG	denotes	containing
T26577	44435-44439	CD	denotes	0.06
T26578	44440-44442	NN	denotes	μg
T26579	44446-44450	NN	denotes	EtBr
T26580	44442-44443	SYM	denotes	/
T26581	44443-44445	NN	denotes	ml
T26582	44450-44451	.	denotes	.
T26583	44451-44562	sentence	denotes	Bands of the correct size were excised and incubated in 100 μl of sterile H2O at 80°C for 10 min to elute DNA.
T26584	44452-44457	NNS	denotes	Bands
T26585	44483-44490	VBN	denotes	excised
T26586	44458-44460	IN	denotes	of
T26587	44461-44464	DT	denotes	the
T26588	44473-44477	NN	denotes	size
T26589	44465-44472	JJ	denotes	correct
T26590	44478-44482	VBD	denotes	were
T26591	44491-44494	CC	denotes	and
T26592	44495-44504	VBN	denotes	incubated
T26593	44505-44507	IN	denotes	in
T26594	44508-44511	CD	denotes	100
T26595	44512-44514	NN	denotes	μl
T26596	44515-44517	IN	denotes	of
T26597	44518-44525	JJ	denotes	sterile
T26598	44526-44529	NN	denotes	H2O
T26599	44530-44532	IN	denotes	at
T26600	44533-44535	CD	denotes	80
T26601	44535-44537	NN	denotes	°C
T26602	44538-44541	IN	denotes	for
T26603	44542-44544	CD	denotes	10
T26604	44545-44548	NN	denotes	min
T26605	44549-44551	TO	denotes	to
T26606	44552-44557	VB	denotes	elute
T26607	44558-44561	NN	denotes	DNA
T26608	44561-44562	.	denotes	.
T26609	44562-44737	sentence	denotes	Reamplification reactions consisted of 1X PCR buffer, 1.5 mM MgCl2, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Taq (Promega) and 10 μl of eluate in a total volume of 50 μl.
T26610	44563-44578	NN	denotes	Reamplification
T26611	44579-44588	NNS	denotes	reactions
T26612	44589-44598	VBD	denotes	consisted
T26613	44599-44601	IN	denotes	of
T26614	44602-44604	NN	denotes	1X
T26615	44609-44615	NN	denotes	buffer
T26616	44605-44608	NN	denotes	PCR
T26617	44615-44617	,	denotes	,
T26618	44617-44620	CD	denotes	1.5
T26619	44621-44623	NN	denotes	mM
T26620	44624-44629	NN	denotes	MgCl2
T26621	44629-44631	,	denotes	,
T26622	44631-44635	CD	denotes	0.17
T26623	44636-44638	NN	denotes	mM
T26624	44639-44644	NNS	denotes	dNTPs
T26625	44644-44646	,	denotes	,
T26626	44646-44647	CD	denotes	1
T26627	44648-44650	NN	denotes	μM
T26628	44656-44662	NN	denotes	primer
T26629	44651-44655	DT	denotes	each
T26630	44662-44664	,	denotes	,
T26631	44664-44667	CD	denotes	0.1
T26632	44668-44672	NN	denotes	unit
T26633	44673-44675	IN	denotes	of
T26634	44676-44679	NN	denotes	Taq
T26635	44680-44681	-LRB-	denotes	(
T26636	44681-44688	NNP	denotes	Promega
T26637	44688-44689	-RRB-	denotes	)
T26638	44690-44693	CC	denotes	and
T26639	44694-44696	CD	denotes	10
T26640	44697-44699	NN	denotes	μl
T26641	44700-44702	IN	denotes	of
T26642	44703-44709	NN	denotes	eluate
T26643	44710-44712	IN	denotes	in
T26644	44713-44714	DT	denotes	a
T26645	44721-44727	NN	denotes	volume
T26646	44715-44720	JJ	denotes	total
T26647	44728-44730	IN	denotes	of
T26648	44731-44733	CD	denotes	50
T26649	44734-44736	NN	denotes	μl
T26650	44736-44737	.	denotes	.
T26651	44737-44806	sentence	denotes	The same cycling parameters were used for reamplification reactions.
T26652	44738-44741	DT	denotes	The
T26653	44755-44765	NNS	denotes	parameters
T26654	44742-44746	JJ	denotes	same
T26655	44747-44754	NN	denotes	cycling
T26656	44771-44775	VBN	denotes	used
T26657	44766-44770	VBD	denotes	were
T26658	44776-44779	IN	denotes	for
T26659	44780-44795	NN	denotes	reamplification
T26660	44796-44805	NNS	denotes	reactions
T26661	44805-44806	.	denotes	.
T26662	44806-44949	sentence	denotes	Products were visualized on 1% 0.5X TBE agarose gels containing 0.06 μg/ml EtBr, excised and purfied using PCR purification columns (Promega).
T26663	44807-44815	NNS	denotes	Products
T26664	44821-44831	VBN	denotes	visualized
T26665	44816-44820	VBD	denotes	were
T26666	44832-44834	IN	denotes	on
T26667	44835-44836	CD	denotes	1
T26668	44836-44837	NN	denotes	%
T26669	44855-44859	NNS	denotes	gels
T26670	44838-44842	NN	denotes	0.5X
T26671	44843-44846	NN	denotes	TBE
T26672	44847-44854	NN	denotes	agarose
T26673	44860-44870	VBG	denotes	containing
T26674	44871-44875	CD	denotes	0.06
T26675	44876-44878	NN	denotes	μg
T26676	44882-44886	NN	denotes	EtBr
T26677	44878-44879	SYM	denotes	/
T26678	44879-44881	NN	denotes	ml
T26679	44886-44888	,	denotes	,
T26680	44888-44895	VBN	denotes	excised
T26681	44896-44899	CC	denotes	and
T26682	44900-44907	VBN	denotes	purfied
T26683	44908-44913	VBG	denotes	using
T26684	44914-44917	NN	denotes	PCR
T26685	44918-44930	NN	denotes	purification
T26686	44931-44938	NNS	denotes	columns
T26687	44939-44940	-LRB-	denotes	(
T26688	44940-44947	NNP	denotes	Promega
T26689	44947-44948	-RRB-	denotes	)
T26690	44948-44949	.	denotes	.
T26691	44949-45106	sentence	denotes	To quantity each fragment 1 μl of each purified product was run on a 1.0% agarose gel containing 0.06 μg/ml EtBr, along with a DNA mass ladder (Invitrogen).
T26692	44950-44952	TO	denotes	To
T26693	44953-44961	VB	denotes	quantity
T26694	45010-45013	VBN	denotes	run
T26695	44962-44966	DT	denotes	each
T26696	44967-44975	NN	denotes	fragment
T26697	44976-44977	CD	denotes	1
T26698	44978-44980	NN	denotes	μl
T26699	44981-44983	IN	denotes	of
T26700	44984-44988	DT	denotes	each
T26701	44998-45005	NN	denotes	product
T26702	44989-44997	VBN	denotes	purified
T26703	45006-45009	VBD	denotes	was
T26704	45014-45016	IN	denotes	on
T26705	45017-45018	DT	denotes	a
T26706	45032-45035	NN	denotes	gel
T26707	45019-45022	CD	denotes	1.0
T26708	45022-45023	NN	denotes	%
T26709	45024-45031	NN	denotes	agarose
T26710	45036-45046	VBG	denotes	containing
T26711	45047-45051	CD	denotes	0.06
T26712	45052-45054	NN	denotes	μg
T26713	45058-45062	NN	denotes	EtBr
T26714	45054-45055	SYM	denotes	/
T26715	45055-45057	NN	denotes	ml
T26716	45062-45064	,	denotes	,
T26717	45064-45069	IN	denotes	along
T26718	45070-45074	IN	denotes	with
T26719	45075-45076	DT	denotes	a
T26720	45086-45092	NN	denotes	ladder
T26721	45077-45080	NN	denotes	DNA
T26722	45081-45085	NN	denotes	mass
T26723	45093-45094	-LRB-	denotes	(
T26724	45094-45104	NNP	denotes	Invitrogen
T26725	45104-45105	-RRB-	denotes	)
T26726	45105-45106	.	denotes	.
T26727	45106-45196	sentence	denotes	In a 96 well plate, 15 ng of each PCR product was added to 5 pM of primer for sequencing.
T26728	45107-45109	IN	denotes	In
T26729	45157-45162	VBN	denotes	added
T26730	45110-45111	DT	denotes	a
T26731	45120-45125	NN	denotes	plate
T26732	45112-45114	CD	denotes	96
T26733	45115-45119	NN	denotes	well
T26734	45125-45127	,	denotes	,
T26735	45127-45129	CD	denotes	15
T26736	45130-45132	NN	denotes	ng
T26737	45133-45135	IN	denotes	of
T26738	45136-45140	DT	denotes	each
T26739	45145-45152	NN	denotes	product
T26740	45141-45144	NN	denotes	PCR
T26741	45153-45156	VBD	denotes	was
T26742	45163-45165	IN	denotes	to
T26743	45166-45167	CD	denotes	5
T26744	45168-45170	NN	denotes	pM
T26745	45171-45173	IN	denotes	of
T26746	45174-45180	NN	denotes	primer
T26747	45181-45184	IN	denotes	for
T26748	45185-45195	NN	denotes	sequencing
T26749	45195-45196	.	denotes	.
T26750	45196-45368	sentence	denotes	The College of Agriculture and Environmental Sciences (CAES) Genomics Facility at the University of California, Davis, performed bidirectional sequencing of each amplicon.
T26751	45197-45200	DT	denotes	The
T26752	45201-45208	NNP	denotes	College
T26753	45267-45275	NN	denotes	Facility
T26754	45209-45211	IN	denotes	of
T26755	45212-45223	NNP	denotes	Agriculture
T26756	45242-45250	NNPS	denotes	Sciences
T26757	45224-45227	CC	denotes	and
T26758	45228-45241	NNP	denotes	Environmental
T26759	45251-45252	-LRB-	denotes	(
T26760	45252-45256	NNP	denotes	CAES
T26761	45256-45257	-RRB-	denotes	)
T26762	45258-45266	NNP	denotes	Genomics
T26763	45316-45325	VBD	denotes	performed
T26764	45276-45278	IN	denotes	at
T26765	45279-45282	DT	denotes	the
T26766	45283-45293	NNP	denotes	University
T26767	45294-45296	IN	denotes	of
T26768	45297-45307	NNP	denotes	California
T26769	45307-45309	,	denotes	,
T26770	45309-45314	NNP	denotes	Davis
T26771	45314-45316	,	denotes	,
T26772	45326-45339	JJ	denotes	bidirectional
T26773	45340-45350	NN	denotes	sequencing
T26774	45351-45353	IN	denotes	of
T26775	45354-45358	DT	denotes	each
T26776	45359-45367	NN	denotes	amplicon
T26777	45367-45368	.	denotes	.
T26935	45370-45378	NN	denotes	Sequence
T26936	45379-45387	NN	denotes	analysis
T26937	45387-45502	sentence	denotes	B6 mRNA sequences for each gene were downloaded from the May 2004 (mm5) UCSC (NCBI Build 33) genome assembly [28].
T26938	45388-45390	NN	denotes	B6
T26939	45396-45405	NNS	denotes	sequences
T26940	45391-45395	NN	denotes	mRNA
T26941	45425-45435	VBN	denotes	downloaded
T26942	45406-45409	IN	denotes	for
T26943	45410-45414	DT	denotes	each
T26944	45415-45419	NN	denotes	gene
T26945	45420-45424	VBD	denotes	were
T26946	45436-45440	IN	denotes	from
T26947	45441-45444	DT	denotes	the
T26948	45488-45496	NN	denotes	assembly
T26949	45445-45448	NNP	denotes	May
T26950	45449-45453	CD	denotes	2004
T26951	45454-45455	-LRB-	denotes	(
T26952	45455-45458	NN	denotes	mm5
T26953	45458-45459	-RRB-	denotes	)
T26954	45460-45464	NNP	denotes	UCSC
T26955	45465-45466	-LRB-	denotes	(
T26956	45471-45476	NNP	denotes	Build
T26957	45466-45470	NNP	denotes	NCBI
T26958	45477-45479	CD	denotes	33
T26959	45479-45480	-RRB-	denotes	)
T26960	45481-45487	NN	denotes	genome
T26961	45497-45498	-LRB-	denotes	[
T26962	45498-45500	CD	denotes	28
T26963	45500-45501	-RRB-	denotes	]
T26964	45501-45502	.	denotes	.
T26965	45502-45654	sentence	denotes	These sequences were imported along with all CAST sequence traces into the SeqMan sequence assembly program (DNASTAR) and manually curated for quality.
T26966	45503-45508	DT	denotes	These
T26967	45509-45518	NNS	denotes	sequences
T26968	45524-45532	VBN	denotes	imported
T26969	45519-45523	VBD	denotes	were
T26970	45533-45538	IN	denotes	along
T26971	45539-45543	IN	denotes	with
T26972	45544-45547	DT	denotes	all
T26973	45562-45568	NNS	denotes	traces
T26974	45548-45552	NN	denotes	CAST
T26975	45553-45561	NN	denotes	sequence
T26976	45569-45573	IN	denotes	into
T26977	45574-45577	DT	denotes	the
T26978	45603-45610	NN	denotes	program
T26979	45578-45584	NNP	denotes	SeqMan
T26980	45585-45593	NN	denotes	sequence
T26981	45594-45602	NN	denotes	assembly
T26982	45611-45612	-LRB-	denotes	(
T26983	45612-45619	NNP	denotes	DNASTAR
T26984	45619-45620	-RRB-	denotes	)
T26985	45621-45624	CC	denotes	and
T26986	45625-45633	RB	denotes	manually
T26987	45634-45641	VBN	denotes	curated
T26988	45642-45645	IN	denotes	for
T26989	45646-45653	NN	denotes	quality
T26990	45653-45654	.	denotes	.
T26991	45654-45691	sentence	denotes	Poor quality reads were resequenced.
T26992	45655-45659	JJ	denotes	Poor
T26993	45660-45667	NN	denotes	quality
T26994	45668-45673	NNS	denotes	reads
T26995	45679-45690	VBN	denotes	resequenced
T26996	45674-45678	VBD	denotes	were
T26997	45690-45691	.	denotes	.
T26998	45691-45803	sentence	denotes	Individual contigs were created for each gene and polymorphisms were detected and curated by manual inspection.
T26999	45692-45702	JJ	denotes	Individual
T27000	45703-45710	NNS	denotes	contigs
T27001	45716-45723	VBN	denotes	created
T27002	45711-45715	VBD	denotes	were
T27003	45724-45727	IN	denotes	for
T27004	45728-45732	DT	denotes	each
T27005	45733-45737	NN	denotes	gene
T27006	45738-45741	CC	denotes	and
T27007	45742-45755	NNS	denotes	polymorphisms
T27008	45761-45769	VBN	denotes	detected
T27009	45756-45760	VBD	denotes	were
T27010	45770-45773	CC	denotes	and
T27011	45774-45781	VBN	denotes	curated
T27012	45782-45784	IN	denotes	by
T27013	45785-45791	JJ	denotes	manual
T27014	45792-45802	NN	denotes	inspection
T27015	45802-45803	.	denotes	.
T20793	34575-34577	IN	denotes	by
T573	0-6	NN	denotes	Genome
R1	T574	T577	amod	wide,isolation
R3	T578	T577	prep	of,isolation
R4	T579	T580	nmod	growth,QTL
R5	T580	T578	pobj	QTL,of
R8	T583	T577	acl	using,isolation
R9	T584	T585	compound	mouse,speed
R10	T585	T586	npadvmod	speed,congenic
R11	T586	T587	amod	congenic,strains
R12	T587	T583	dobj	strains,using
R13	T592	T593	amod	High,growth
R14	T593	T594	nmod	growth,modifier
R15	T594	T598	nsubjpass	modifier,identified
R19	T599	T594	cc	and,modifier
R20	T600	T601	npadvmod	background,independent
R21	T601	T602	amod	independent,loci
R22	T602	T594	conj	loci,modifier
R25	T605	T602	punct	(,loci
R26	T606	T602	appos	QTL,loci
R27	T607	T594	punct	),modifier
R28	T608	T594	acl	affecting,modifier
R29	T609	T608	dobj	growth,affecting
R30	T610	T609	punct	", ",growth
R31	T611	T609	conj	adiposity,growth
R32	T612	T611	cc	and,adiposity
R33	T613	T614	compound	carcass,composition
R34	T614	T611	conj	composition,adiposity
R35	T615	T598	auxpass	were,identified
R36	T616	T598	advmod	previously,identified
R37	T617	T598	prep	on,identified
R38	T618	T619	compound	mouse,chromosomes
R39	T619	T617	pobj	chromosomes,on
R40	T620	T619	punct	(,chromosomes
R41	T621	T619	appos	MMU,chromosomes
R42	T622	T619	punct	),chromosomes
R43	T623	T619	appos	1,chromosomes
R44	T624	T623	punct	", ",1
R45	T625	T623	conj	2,1
R46	T626	T625	punct	", ",2
R47	T627	T625	conj	5,2
R48	T628	T627	punct	", ",5
R49	T629	T627	conj	8,5
R50	T630	T629	punct	", ",8
R51	T631	T629	conj	9,8
R52	T632	T631	punct	", ",9
R53	T633	T631	conj	11,9
R54	T634	T633	cc	and,11
R55	T635	T633	conj	17,11
R56	T636	T598	punct	.,identified
R57	T638	T639	aux	To,confirm
R58	T639	T640	advcl	confirm,developed
R59	T641	T639	cc	and,confirm
R60	T642	T643	advmod	further,characterize
R61	T643	T639	conj	characterize,confirm
R62	T644	T645	det	each,QTL
R63	T645	T643	dobj	QTL,characterize
R64	T646	T640	punct	", ",developed
R65	T647	T648	nummod	two,panels
R66	T648	T640	nsubjpass	panels,developed
R67	T649	T648	prep	of,panels
R68	T650	T651	npadvmod	speed,congenic
R69	T651	T652	amod	congenic,strains
R70	T652	T649	pobj	strains,of
R71	T653	T640	auxpass	were,developed
R72	T654	T640	prep	by,developed
R73	T655	T654	pcomp	introgressing,by
R74	T656	T657	nmod	CAST,EiJ
R75	T657	T659	nmod	EiJ,alleles
R77	T659	T655	dobj	alleles,introgressing
R82	T664	T655	prep	onto,introgressing
R83	T665	T666	preconj	either,hg
R84	T666	T674	nmod	hg,backgrounds
R92	T674	T664	pobj	backgrounds,onto
R100	T682	T680	appos	6J,type
R101	T683	T682	punct	/,6J
R106	T688	T640	punct	.,developed
R107	T692	T693	det	The,panel
R108	T693	T697	nsubjpass	panel,developed
R112	T698	T697	auxpass	was,developed
R113	T699	T697	prep	by,developed
R114	T700	T699	pcomp	introgressing,by
R115	T701	T702	nummod	four,regions
R116	T702	T700	dobj	regions,introgressing
R119	T705	T702	acl	spanning,regions
R120	T706	T705	dobj	MMU2,spanning
R121	T707	T706	prep	in,MMU2
R122	T708	T709	poss	its,entirety
R123	T709	T707	pobj	entirety,in
R124	T710	T700	prep	onto,introgressing
R125	T711	T712	preconj	both,HG
R126	T712	T713	nmod	HG,backgrounds
R127	T713	T710	pobj	backgrounds,onto
R130	T716	T700	punct	", ",introgressing
R131	T717	T700	prep	for,introgressing
R132	T718	T719	det	a,total
R133	T719	T717	pobj	total,for
R134	T720	T719	prep	of,total
R135	T721	T722	nummod	eight,strains
R136	T722	T720	pobj	strains,of
R137	T723	T697	punct	.,developed
R138	T725	T726	amod	Phenotypic,characterization
R139	T726	T727	nsubj	characterization,confirmed
R140	T728	T726	prep	of,characterization
R141	T729	T730	det	the,panel
R142	T730	T728	pobj	panel,of
R144	T732	T733	det	the,segregation
R145	T733	T727	dobj	segregation,confirmed
R146	T734	T733	prep	of,segregation
R147	T735	T736	amod	multiple,growth
R148	T736	T737	nmod	growth,QTL
R149	T737	T734	pobj	QTL,of
R152	T740	T727	cc	and,confirmed
R153	T741	T742	advmod	strongly,suggested
R154	T742	T727	conj	suggested,confirmed
R155	T743	T744	mark	that,modify
R156	T744	T742	ccomp	modify,suggested
R162	T750	T751	det	the,effects
R163	T751	T744	dobj	effects,modify
R164	T752	T751	prep	of,effects
R165	T753	T754	det	the,deletion
R166	T754	T752	pobj	deletion,of
R168	T756	T727	punct	.,confirmed
R169	T758	T759	det	The,panel
R170	T759	T761	nsubj	panel,consisted
R172	T762	T761	prep	of,consisted
R173	T763	T764	amod	individual,regions
R174	T764	T762	pobj	regions,of
R176	T766	T764	prep	on,regions
R177	T767	T768	det	an,background
R178	T768	T766	pobj	background,on
R180	T770	T764	prep	for,regions
R181	T771	T772	det	each,QTL
R182	T772	T770	pobj	QTL,for
R183	T773	T764	prep	on,regions
R184	T774	T775	nmod	MMU,1
R185	T775	T773	pobj	1,on
R186	T776	T775	punct	", ",1
R187	T777	T775	conj	5,1
R188	T778	T777	punct	", ",5
R189	T779	T777	conj	8,5
R190	T780	T779	punct	", ",8
R191	T781	T779	conj	9,8
R192	T782	T781	punct	", ",9
R193	T783	T781	conj	11,9
R194	T784	T783	cc	and,11
R195	T785	T783	conj	17,11
R196	T786	T761	punct	.,consisted
R197	T788	T789	prep	Of,characterized
R198	T790	T791	det	the,strains
R199	T791	T788	pobj	strains,Of
R202	T794	T789	punct	", ",characterized
R203	T795	T789	nsubjpass	five,characterized
R204	T796	T789	auxpass	were,characterized
R205	T797	T789	advmod	successfully,characterized
R206	T798	T789	cc	and,characterized
R207	T799	T789	conj	displayed,characterized
R208	T800	T801	amod	significant,differences
R209	T801	T799	dobj	differences,displayed
R210	T802	T801	prep	in,differences
R211	T803	T802	pobj	growth,in
R212	T804	T803	cc	and,growth
R213	T805	T804	punct	/,and
R214	T806	T804	cc	or,and
R215	T807	T803	conj	obesity,growth
R216	T808	T809	mark	as,compared
R217	T809	T799	advcl	compared,displayed
R218	T810	T809	prep	to,compared
R219	T811	T810	pobj	controls,to
R220	T812	T789	punct	.,characterized
R221	T814	T815	det	All,five
R222	T815	T816	nsubj	five,displayed
R223	T816	T817	ccomp	displayed,unmasked
R224	T818	T816	dobj	phenotypes,displayed
R225	T819	T818	amod	similar,phenotypes
R226	T820	T819	prep	to,similar
R227	T821	T820	pobj	those,to
R228	T822	T823	advmod	originally,attributed
R229	T823	T821	acl	attributed,those
R230	T824	T823	prep	to,attributed
R231	T825	T826	det	each,QTL
R232	T826	T824	pobj	QTL,to
R233	T827	T817	punct	", ",unmasked
R234	T828	T817	advmod	however,unmasked
R235	T829	T817	punct	", ",unmasked
R236	T830	T831	amod	novel,phenotypes
R237	T831	T817	nsubjpass	phenotypes,unmasked
R238	T832	T817	auxpass	were,unmasked
R239	T833	T817	prep	in,unmasked
R240	T834	T833	pobj	several,in
R241	T835	T834	prep	of,several
R242	T836	T837	det	the,strains
R243	T837	T835	pobj	strains,of
R244	T838	T817	prep	including,unmasked
R245	T839	T840	npadvmod	sex,specific
R246	T840	T842	amod	specific,effects
R248	T842	T838	pobj	effects,including
R249	T843	T817	punct	.,unmasked
R250	T847	T848	det	The,strains
R251	T848	T851	nsubj	strains,constitute
R254	T852	T848	acl	developed,strains
R255	T853	T852	advmod	herein,developed
R256	T854	T855	det	an,resource
R257	T855	T851	dobj	resource,constitute
R260	T858	T851	cc	and,constitute
R261	T859	T851	conj	provide,constitute
R262	T860	T861	det	the,foundation
R263	T861	T859	dobj	foundation,provide
R264	T862	T863	aux	to,identify
R265	T863	T861	advcl	identify,foundation
R266	T864	T865	det	the,nature
R267	T865	T863	dobj	nature,identify
R269	T867	T865	prep	of,nature
R270	T868	T869	amod	genetic,variation
R271	T869	T867	pobj	variation,of
R272	T870	T869	acl	influencing,variation
R273	T871	T870	dobj	growth,influencing
R274	T872	T871	cc	and,growth
R275	T873	T871	conj	obesity,growth
R276	T874	T851	punct	.,constitute
R277	T573	T574	npadvmod	Genome,wide
R295	T2734	T2732	pobj	mutations,by
R296	T2735	T2734	compound	gene,mutations
R305	T2746	T2739	dobj	complexity,mimic
R306	T2747	T2746	amod	genetic,complexity
R314	T2755	T2753	pobj	population,in
R315	T2756	T2755	amod	human,population
R329	T2772	T2770	pobj	effects,by
R330	T2773	T2772	amod	small,effects
R331	T2774	T2773	prep	to,small
R332	T2775	T2774	amod	moderate,to
R333	T2776	T2772	amod	direct,effects
R336	T2779	T2777	pobj	loci,of
R337	T2780	T2779	compound	trait,loci
R351	T2794	T2796	compound	environment,interactions
R352	T2795	T2794	punct	-,environment
R356	T2800	T2810	ccomp	localized,made
R357	T2801	T2799	pobj	date,To
R358	T2802	T2803	amod	numerous,QTL
R359	T2803	T2800	nsubjpass	QTL,localized
R360	T2804	T2805	nmod	mouse,growth
R361	T2805	T2803	nmod	growth,QTL
R362	T2806	T2805	cc	and,growth
R363	T2807	T2805	conj	obesity,growth
R364	T2808	T2800	aux	have,localized
R365	T2809	T2800	auxpass	been,localized
R367	T2812	T2800	parataxis	2,localized
R368	T2813	T2812	nummod	1,2
R369	T2814	T2812	punct	",",2
R381	T2826	T2824	dobj	nature,determining
R382	T2827	T2826	amod	specific,nature
R385	T2830	T2828	pobj	variants,of
R386	T2831	T2830	amod	underlying,variants
R387	T2832	T2830	amod	genetic,variants
R393	T2840	T2838	advcl	map,used
R394	T2841	T2840	advmod	fine,map
R398	T2903	T2904	amod	congenic,analysis
R399	T2845	T2846	dep	which,designed
R400	T2904	T2905	nsubj	analysis,method
R401	T2846	T2844	relcl	designed,strains
R402	T2905	T2899	ccomp	method,considers
R403	T2906	T2905	det	an,method
R404	T2847	T2846	auxpass	are,designed
R405	T2907	T2905	amod	excellent,method
R406	T2908	T2909	aux	to,confirm
R407	T2909	T2905	advcl	confirm,method
R408	T2848	T2849	aux	to,convert
R409	T2910	T2909	cc	and,confirm
R410	T2911	T2912	advmod	subsequently,map
R411	T2849	T2846	advcl	convert,designed
R412	T2912	T2909	conj	map,confirm
R413	T2913	T2912	advmod	fine,map
R414	T2914	T2912	dobj	QTL,map
R415	T2915	T2916	punct	[,3
R416	T2850	T2851	det	a,trait
R417	T2916	T2899	parataxis	3,considers
R418	T2917	T2916	punct	],3
R419	T2851	T2849	dobj	trait,convert
R420	T2918	T2899	punct	.,considers
R421	T2920	T2921	advmod	Traditionally,developed
R422	T2852	T2851	amod	complex,trait
R423	T2922	T2921	punct	", ",developed
R424	T2923	T2924	amod	congenic,strains
R425	T2853	T2851	amod	polygenic,trait
R426	T2924	T2921	nsubjpass	strains,developed
R427	T2925	T2921	auxpass	are,developed
R428	T2854	T2849	prep	into,convert
R429	T2926	T2921	prep	by,developed
R430	T2927	T2926	pcomp	introgressing,by
R431	T2928	T2929	compound	QTL,alleles
R432	T2929	T2927	dobj	alleles,introgressing
R433	T2855	T2854	pobj	one,into
R434	T2930	T2929	prep	from,alleles
R435	T2931	T2932	det	a,strain
R436	T2932	T2930	pobj	strain,from
R437	T2933	T2932	compound	donor,strain
R438	T2934	T2932	punct	", ",strain
R439	T2856	T2857	dep	that,is
R440	T2935	T2936	poss	whose,boundaries
R441	T2936	T2937	dep	boundaries,defined
R442	T2857	T2855	relcl	is,one
R443	T2937	T2932	relcl	defined,strain
R444	T2858	T2859	advmod	mono,oligogenic
R445	T2938	T2937	auxpass	are,defined
R446	T2939	T2937	agent	by,defined
R447	T2940	T2941	amod	genetic,markers
R448	T2859	T2857	acomp	oligogenic,is
R449	T2941	T2939	pobj	markers,by
R450	T2942	T2927	punct	", ",introgressing
R451	T2943	T2927	prep	on,introgressing
R452	T2860	T2859	punct	-,oligogenic
R453	T2944	T2945	det	the,background
R454	T2945	T2943	pobj	background,on
R455	T2946	T2945	amod	genetic,background
R456	T2861	T2859	cc	or,oligogenic
R457	T2947	T2945	prep	of,background
R458	T2948	T2949	det	a,strain
R459	T2949	T2947	pobj	strain,of
R460	T2862	T2837	punct	.,are
R461	T2950	T2949	compound	recipient,strain
R462	T2951	T2927	prep	via,introgressing
R463	T2864	T2865	nsubjpass	This,accomplished
R464	T2952	T2953	nummod	10,backcrosses
R465	T2953	T2951	pobj	backcrosses,via
R466	T2954	T2955	punct	[,4
R467	T2955	T2927	parataxis	4,introgressing
R468	T2956	T2955	punct	],4
R469	T2866	T2865	auxpass	is,accomplished
R470	T2957	T2921	punct	.,developed
R471	T2959	T2960	mark	While,straightforward
R472	T2960	T2962	advcl	straightforward,is
R473	T2867	T2865	prep	by,accomplished
R474	T2961	T2960	advmod	technically,straightforward
R475	T2963	T2962	nsubj	this,is
R476	T2868	T2867	pcomp	eliminating,by
R477	T2964	T2965	det	a,endeavor
R478	T2965	T2962	attr	endeavor,is
R479	T2966	T2967	npadvmod	time,consuming
R480	T2869	T2868	xcomp	segregating,eliminating
R481	T2967	T2965	amod	consuming,endeavor
R482	T2968	T2965	acl	taking,endeavor
R483	T2969	T2970	quantmod	over,three
R484	T2870	T2871	amod	genetic,variation
R485	T2970	T2971	nummod	three,years
R486	T2971	T2968	dobj	years,taking
R487	T2972	T2973	aux	to,construct
R488	T2973	T2968	advcl	construct,taking
R489	T2974	T2975	det	a,strain
R490	T2975	T2973	dobj	strain,construct
R491	T2871	T2869	dobj	variation,segregating
R492	T2976	T2975	amod	single,strain
R493	T2977	T2962	punct	.,is
R494	T2872	T2869	prep	outside,segregating
R495	T2979	T2980	det	The,approach
R496	T2980	T2983	nsubj	approach,is
R497	T2873	T2874	det	the,locus
R498	T2981	T2982	npadvmod	speed,congenic
R499	T2982	T2980	amod	congenic,approach
R500	T2984	T2985	det	an,alternative
R501	T2874	T2872	pobj	locus,outside
R502	T2985	T2983	attr	alternative,is
R503	T2986	T2985	prep	to,alternative
R504	T2875	T2874	prep	of,locus
R505	T2987	T2988	det	this,process
R506	T2988	T2986	pobj	process,to
R507	T2989	T2988	amod	lengthy,process
R508	T2876	T2875	pobj	interest,of
R509	T2990	T2983	cc	and,is
R510	T2991	T2992	aux	can,reduce
R511	T2992	T2983	conj	reduce,is
R512	T2993	T2994	det	the,number
R513	T2877	T2868	cc	and,eliminating
R514	T2994	T2992	dobj	number,reduce
R515	T2995	T2994	prep	of,number
R516	T2878	T2868	conj	reducing,eliminating
R517	T2996	T2997	amod	required,backcrosses
R518	T2997	T2995	pobj	backcrosses,of
R519	T2998	T2992	prep	from,reduce
R520	T2879	T2880	det	the,variation
R521	T2999	T2998	pobj	10,from
R522	T3000	T2992	prep	to,reduce
R523	T3001	T3000	pobj	five,to
R524	T2880	T2878	dobj	variation,reducing
R525	T3002	T3003	punct	[,6
R526	T3003	T2992	parataxis	6,reduce
R527	T3004	T3003	nummod	5,6
R528	T2881	T2880	amod	environmental,variation
R529	T3005	T3003	punct	",",6
R530	T3006	T3003	punct	],6
R531	T3007	T2983	punct	.,is
R532	T2882	T2880	acl	influencing,variation
R533	T2883	T2884	det	a,trait
R534	T2884	T2882	dobj	trait,influencing
R535	T3009	T3010	det	This,strategy
R536	T2885	T2878	prep	by,reducing
R537	T3010	T3011	nsubj	strategy,uses
R538	T3012	T3013	npadvmod	marker,assisted
R539	T3013	T3015	amod	assisted,selection
R540	T3014	T3013	punct	-,assisted
R541	T3015	T3011	dobj	selection,uses
R542	T2886	T2885	pcomp	characterizing,by
R543	T3016	T3017	aux	to,identify
R544	T3017	T3011	advcl	identify,uses
R545	T3018	T3019	amod	male,mice
R546	T2887	T2888	amod	large,numbers
R547	T3019	T3017	dobj	mice,identify
R548	T2888	T2886	dobj	numbers,characterizing
R549	T3020	T3019	acl	inheriting,mice
R550	T3021	T3022	amod	fewer,alleles
R551	T2889	T2888	prep	of,numbers
R552	T2890	T2891	advmod	genetically,identical
R553	T3022	T3020	dobj	alleles,inheriting
R554	T3023	T3022	compound	donor,alleles
R555	T2891	T2892	amod	identical,mice
R556	T3024	T3022	punct	", ",alleles
R557	T3025	T3026	mark	than,expected
R558	T3026	T3022	advcl	expected,alleles
R559	T2892	T2889	pobj	mice,of
R560	T3027	T3020	prep	on,inheriting
R561	T3028	T3027	amod	average,on
R562	T3029	T3011	punct	", ",uses
R563	T2893	T2865	punct	.,accomplished
R564	T3030	T3011	prep	during,uses
R565	T3031	T3032	det	each,backcross
R566	T2895	T2896	det	The,Consortium
R567	T3032	T3030	pobj	backcross,during
R568	T3033	T3011	punct	.,uses
R569	T2896	T2899	nsubj	Consortium,considers
R570	T3035	T3036	amod	Numerous,congenics
R571	T3036	T3041	nsubjpass	congenics,used
R572	T3037	T3038	advmod	traditionally,developed
R573	T2897	T2898	compound	Complex,Trait
R574	T3038	T3036	amod	developed,congenics
R575	T3039	T3038	cc	and,developed
R576	T3040	T3038	conj	speed,developed
R577	T2898	T2896	compound	Trait,Consortium
R578	T3042	T3041	aux	have,used
R579	T3043	T3041	auxpass	been,used
R580	T2900	T2896	punct	(,Consortium
R581	T3044	T3045	aux	to,isolate
R582	T3045	T3041	advcl	isolate,used
R583	T3046	T3045	advmod	successfully,isolate
R584	T3047	T3048	compound	mouse,QTL
R585	T2901	T2896	appos	CTC,Consortium
R586	T3048	T3045	dobj	QTL,isolate
R587	T3049	T3045	prep	for,isolate
R588	T2902	T2899	punct	),considers
R590	T3051	T3049	pobj	array,for
R591	T3052	T3051	amod	wide,array
R595	T3114	T3115	det	The,role
R596	T3056	T3051	prep	including,array
R597	T3057	T3056	pobj	growth,including
R598	T3058	T3057	cc	and,growth
R599	T3059	T3057	conj	obesity,growth
R600	T3115	T3116	nsubjpass	role,confirmed
R601	T3060	T3061	punct	[,7
R602	T3061	T3041	parataxis	7,used
R603	T3062	T3063	punct	-,13
R604	T3117	T3115	prep	of,role
R605	T3063	T3061	prep	13,7
R606	T3064	T3061	punct	],7
R607	T3065	T3041	punct	.,used
R608	T3067	T3068	det	The,mouse
R609	T3118	T3117	pobj	Socs2,of
R610	T3068	T3079	nsubj	mouse,is
R611	T3069	T3070	nmod	C57Bl,hg
R613	T3119	T3115	prep	in,role
R614	T3071	T3070	punct	/,hg
R615	T3072	T3070	nmod	6J,hg
R616	T3073	T3070	punct	-,hg
R617	T3074	T3070	nmod	hg,hg
R618	T3120	T3121	det	the,phenotype
R619	T3075	T3070	punct	/,hg
R620	T3076	T3077	punct	(,HG
R621	T3077	T3070	parataxis	HG,hg
R622	T3121	T3119	pobj	phenotype,in
R623	T3078	T3077	punct	),HG
R624	T3080	T3081	det	a,model
R625	T3122	T3121	compound	HG,phenotype
R626	T3081	T3079	attr	model,is
R627	T3082	T3081	prep	of,model
R628	T3083	T3084	amod	systemic,overgrowth
R629	T3123	T3116	auxpass	was,confirmed
R630	T3084	T3082	pobj	overgrowth,of
R631	T3085	T3081	acl	resulting,model
R632	T3124	T3116	agent	by,confirmed
R633	T3086	T3085	prep	from,resulting
R634	T3087	T3088	det	a,deletion
R635	T3088	T3086	pobj	deletion,from
R636	T3125	T3126	det	an,mouse
R637	T3089	T3088	amod	spontaneous,deletion
R638	T3090	T3088	prep	on,deletion
R639	T3091	T3090	pobj	MMU10,on
R640	T3126	T3124	pobj	mouse,by
R641	T3092	T3091	punct	", ",MMU10
R642	T3093	T3094	dep	which,eliminates
R643	T3094	T3091	relcl	eliminates,MMU10
R644	T3095	T3094	dobj	expression,eliminates
R645	T3096	T3095	prep	of,expression
R646	T3097	T3098	det	the,gene
R647	T3127	T3128	advmod	independently,engineered
R648	T3098	T3096	pobj	gene,of
R649	T3099	T3098	nmod	Socs2,gene
R650	T3100	T3099	punct	(,Socs2
R651	T3101	T3099	appos	suppressor,Socs2
R652	T3128	T3126	amod	engineered,mouse
R653	T3102	T3101	prep	of,suppressor
R654	T3103	T3104	compound	cytokine,signaling
R655	T3104	T3102	pobj	signaling,of
R656	T3129	T3130	nmod	Socs2,knockout
R657	T3105	T3104	nummod	2,signaling
R658	T3106	T3098	punct	),gene
R659	T3107	T3108	punct	[,14
R660	T3130	T3126	compound	knockout,mouse
R661	T3131	T3129	punct	-,Socs2
R662	T3108	T3079	parataxis	14,is
R663	T3109	T3110	punct	-,16
R664	T3132	T3129	punct	/,Socs2
R665	T3133	T3129	punct	-,Socs2
R666	T3110	T3108	prep	16,14
R667	T3134	T3135	dep	which,shared
R668	T3111	T3108	punct	],14
R669	T3112	T3079	punct	.,is
R674	T3220	T3219	prep	of,basis
R675	T3221	T3222	det	these,interactions
R676	T3139	T3138	pobj	phenotypes,of
R677	T3222	T3220	pobj	interactions,of
R678	T3223	T3217	punct	", ",forms
R679	T3224	T3217	advcl	implying,forms
R680	T3140	T3137	prep	in,number
R681	T3225	T3226	mark	that,are
R682	T3226	T3224	ccomp	are,implying
R683	T3141	T3140	pobj	common,in
R684	T3227	T3228	det	the,gene
R685	T3228	T3226	nsubj	gene,are
R686	T3229	T3228	amod	known,gene
R687	T3230	T3228	cc	and,gene
R688	T3142	T3141	prep	with,common
R689	T3231	T3232	poss	its,modifiers
R690	T3232	T3228	conj	modifiers,gene
R691	T3143	T3142	pobj	HG,with
R692	T3233	T3226	attr	members,are
R693	T3234	T3233	prep	of,members
R694	T3144	T3137	punct	", ",number
R695	T3235	T3236	det	the,pathway
R696	T3236	T3234	pobj	pathway,of
R697	T3237	T3236	amod	same,pathway
R698	T3238	T3236	amod	biochemical,pathway
R699	T3239	T3238	cc	or,biochemical
R700	T3240	T3238	conj	metabolic,biochemical
R701	T3241	T3217	punct	.,forms
R702	T3145	T3137	prep	including,number
R703	T3243	T3244	amod	Different,backgrounds
R704	T3244	T3246	nsubjpass	backgrounds,shown
R705	T3245	T3244	amod	genetic,backgrounds
R706	T3146	T3145	pobj	gigantism,including
R707	T3247	T3246	aux	have,shown
R708	T3248	T3246	auxpass	been,shown
R709	T3147	T3148	punct	[,17
R710	T3249	T3250	aux	to,modify
R711	T3148	T3116	parataxis	17,confirmed
R712	T3250	T3246	xcomp	modify,shown
R713	T3251	T3252	det	the,effects
R714	T3252	T3250	dobj	effects,modify
R715	T3149	T3148	punct	],17
R716	T3253	T3254	npadvmod	growth,enhancing
R717	T3254	T3252	amod	enhancing,effects
R718	T3255	T3254	punct	-,enhancing
R719	T3150	T3116	punct	.,confirmed
R720	T3256	T3252	prep	of,effects
R721	T3257	T3256	pobj	hg,of
R722	T3258	T3259	punct	[,22
R723	T3259	T3246	parataxis	22,shown
R724	T3152	T3153	nsubjpass	QTL,referred
R725	T3260	T3259	nummod	15,22
R726	T3261	T3259	punct	",",22
R727	T3262	T3259	punct	],22
R728	T3154	T3155	dep	which,alter
R729	T3263	T3246	punct	.,shown
R730	T3265	T3266	mark	Since,is
R731	T3266	T3272	advcl	is,is
R732	T3267	T3268	det	the,function
R733	T3155	T3152	relcl	alter,QTL
R734	T3268	T3266	nsubj	function,is
R735	T3269	T3268	amod	primary,function
R736	T3270	T3268	prep	of,function
R737	T3156	T3157	det	the,effects
R738	T3271	T3270	pobj	Socs2,of
R739	T3157	T3155	dobj	effects,alter
R740	T3273	T3274	aux	to,regulate
R741	T3274	T3266	xcomp	regulate,is
R742	T3275	T3274	advmod	negatively,regulate
R743	T3276	T3277	compound	growth,hormone
R744	T3158	T3157	amod	phenotypic,effects
R745	T3277	T3274	dobj	hormone,regulate
R746	T3278	T3277	punct	(,hormone
R747	T3159	T3157	prep	of,effects
R748	T3279	T3277	appos	Gh,hormone
R749	T3280	T3266	punct	),is
R750	T3281	T3282	punct	[,23
R751	T3282	T3266	parataxis	23,is
R752	T3160	T3161	det	another,locus
R753	T3283	T3282	punct	],23
R754	T3284	T3272	punct	", ",is
R755	T3285	T3272	nsubj	it,is
R756	T3161	T3159	pobj	locus,of
R757	T3286	T3272	acomp	likely,is
R758	T3287	T3288	det	these,effects
R759	T3162	T3153	auxpass	are,referred
R760	T3288	T3290	nsubj	effects,are
R761	T3289	T3288	compound	background,effects
R762	T3163	T3153	prep	to,referred
R763	T3290	T3286	advcl	are,likely
R764	T3291	T3292	det	the,result
R765	T3164	T3153	prep	as,referred
R766	T3292	T3290	attr	result,are
R767	T3293	T3292	prep	of,result
R768	T3294	T3295	nsubj	polymorphism,influencing
R769	T3295	T3293	pcomp	influencing,of
R770	T3165	T3166	compound	modifier,QTL
R771	T3296	T3295	dobj	interactions,influencing
R772	T3297	T3296	prep	between,interactions
R773	T3298	T3297	pobj	members,between
R774	T3166	T3164	pobj	QTL,as
R775	T3299	T3298	prep	of,members
R776	T3300	T3301	det	the,pathway
R777	T3301	T3299	pobj	pathway,of
R778	T3167	T3168	punct	[,18
R779	T3302	T3303	compound	Gh,signaling
R780	T3303	T3301	compound	signaling,pathway
R781	T3304	T3272	punct	.,is
R782	T3168	T3153	parataxis	18,referred
R783	T3306	T3307	advmod	Thus,has
R784	T3169	T3168	punct	],18
R785	T3308	T3307	punct	", ",has
R786	T3309	T3307	nsubj	identification,has
R787	T3170	T3153	punct	.,referred
R788	T3310	T3309	prep	of,identification
R789	T3311	T3312	compound	hg,modifiers
R790	T3312	T3310	pobj	modifiers,of
R791	T3172	T3173	compound	Modifier,QTL
R792	T3313	T3314	det	the,potential
R793	T3314	T3307	dobj	potential,has
R794	T3315	T3316	aux	to,uncover
R795	T3316	T3314	acl	uncover,potential
R796	T3173	T3174	nsubjpass	QTL,mapped
R797	T3317	T3318	amod	novel,members
R798	T3318	T3316	dobj	members,uncover
R799	T3319	T3318	prep	of,members
R800	T3320	T3321	advmod	metabolically,important
R801	T3321	T3322	amod	important,pathways
R802	T3322	T3319	pobj	pathways,of
R803	T3175	T3174	aux	have,mapped
R804	T3323	T3318	cc	or,members
R805	T3324	T3325	advmod	previously,unknown
R806	T3325	T3326	amod	unknown,convergences
R807	T3176	T3174	auxpass	been,mapped
R808	T3177	T3174	prep	for,mapped
R809	T3326	T3318	conj	convergences,members
R810	T3178	T3179	amod	numerous,traits
R811	T3327	T3326	prep	between,convergences
R812	T3328	T3327	pobj	pathways,between
R813	T3329	T3307	punct	.,has
R814	T3179	T3177	pobj	traits,for
R815	T3331	T3332	prep	As,identified
R816	T3180	T3174	cc	and,mapped
R817	T3333	T3334	det	an,step
R818	T3334	T3331	pobj	step,As
R819	T3181	T3182	prep	in,is
R820	T3335	T3334	amod	initial,step
R821	T3336	T3332	punct	", ",identified
R822	T3337	T3338	nmod	growth,QTL
R823	T3182	T3174	conj	is,mapped
R824	T3338	T3332	nsubjpass	QTL,identified
R825	T3339	T3337	cc	and,growth
R826	T3340	T3341	compound	carcass,composition
R827	T3183	T3184	det	these,studies
R828	T3341	T3337	conj	composition,growth
R829	T3342	T3332	auxpass	were,identified
R830	T3343	T3332	prep	in,identified
R831	T3184	T3181	pobj	studies,in
R832	T3344	T3345	det	a,cross
R833	T3345	T3343	pobj	cross,in
R834	T3346	T3345	prep	between,cross
R835	T3185	T3186	det	the,locus
R836	T3347	T3348	compound	CAST,EiJ
R837	T3348	T3346	pobj	EiJ,between
R838	T3349	T3348	punct	/,EiJ
R839	T3186	T3182	nsubj	locus,is
R840	T3350	T3348	punct	(,EiJ
R841	T3351	T3348	appos	CAST,EiJ
R842	T3352	T3348	punct	),EiJ
R843	T3187	T3186	amod	modified,locus
R844	T3353	T3348	cc	and,EiJ
R845	T3354	T3348	conj	HG,EiJ
R846	T3355	T3356	punct	[,24
R847	T3188	T3182	advmod	typically,is
R848	T3356	T3332	parataxis	24,identified
R849	T3357	T3356	punct	],24
R850	T3358	T3332	punct	.,identified
R851	T3189	T3190	det	a,gene
R852	T3360	T3361	prep	In,assayed
R853	T3362	T3363	det	the,F2
R854	T3363	T3360	pobj	F2,In
R855	T3364	T3361	punct	", ",assayed
R856	T3190	T3182	attr	gene,is
R857	T3365	T3361	nsubjpass	mice,assayed
R858	T3366	T3365	amod	homozygous,mice
R859	T3191	T3190	amod	known,gene
R860	T3367	T3366	prep	for,homozygous
R861	T3192	T3190	acl	containing,gene
R862	T3368	T3369	det	the,deletion
R863	T3369	T3367	pobj	deletion,for
R864	T3193	T3194	det	a,mutation
R865	T3370	T3369	compound	hg,deletion
R866	T3371	T3372	punct	(,hg
R867	T3372	T3369	parataxis	hg,deletion
R868	T3194	T3192	dobj	mutation,containing
R869	T3373	T3372	compound	hg,hg
R870	T3374	T3372	punct	/,hg
R871	T3375	T3372	punct	),hg
R872	T3195	T3196	advmod	spontaneously,arisen
R873	T3376	T3366	cc	and,homozygous
R874	T3196	T3194	amod	arisen,mutation
R875	T3377	T3378	amod	wild,type
R876	T3378	T3366	conj	type,homozygous
R877	T3379	T3378	punct	(,type
R878	T3380	T3381	punct	+,+
R879	T3197	T3196	cc	or,arisen
R880	T3381	T3378	appos	+,type
R881	T3382	T3381	punct	/,+
R882	T3383	T3361	punct	),assayed
R883	T3198	T3196	conj	engineered,arisen
R884	T3384	T3361	auxpass	were,assayed
R885	T3385	T3361	cc	and,assayed
R886	T3199	T3194	prep	with,mutation
R887	T3386	T3387	compound	hg,modifier
R888	T3387	T3388	compound	modifier,QTL
R889	T3388	T3389	nsubjpass	QTL,defined
R890	T3389	T3361	conj	defined,assayed
R891	T3200	T3201	amod	major,effects
R892	T3390	T3389	auxpass	were,defined
R893	T3391	T3389	prep	as,defined
R894	T3392	T3391	pobj	those,as
R895	T3201	T3199	pobj	effects,with
R896	T3393	T3392	preconj	either,those
R897	T3394	T3392	amod	absent,those
R898	T3202	T3201	amod	phenotypic,effects
R899	T3395	T3394	prep	in,absent
R900	T3396	T3397	punct	+,+
R901	T3397	T3399	punct	+,mice
R902	T3398	T3397	punct	/,+
R903	T3203	T3194	punct	", ",mutation
R904	T3399	T3395	pobj	mice,in
R905	T3400	T3394	cc	and,absent
R906	T3401	T3394	conj	segregating,absent
R907	T3402	T3401	prep	in,segregating
R908	T3403	T3404	compound	hg,hg
R909	T3404	T3402	pobj	hg,in
R910	T3204	T3205	amod	such,as
R911	T3405	T3404	punct	/,hg
R912	T3406	T3392	cc	or,those
R913	T3407	T3392	conj	loci,those
R914	T3408	T3407	prep	with,loci
R915	T3205	T3194	prep	as,mutation
R916	T3409	T3410	amod	altered,action
R917	T3410	T3408	pobj	action,with
R918	T3411	T3410	compound	gene,action
R919	T3206	T3205	pobj	hg,as
R920	T3412	T3410	amod	dependent,action
R921	T3413	T3412	prep	on,dependent
R922	T3414	T3413	pobj	background,on
R923	T3207	T3208	punct	[,11
R924	T3415	T3389	punct	.,defined
R925	T3208	T3182	parataxis	11,is
R926	T3417	T3418	nummod	Four,hg
R927	T3418	T3419	compound	hg,QTL
R928	T3419	T3421	nsubjpass	QTL,identified
R929	T3420	T3419	compound	modifier,QTL
R930	T3209	T3208	punct	",",11
R931	T3422	T3419	punct	(,QTL
R932	T3423	T3419	appos	Wg2,QTL
R933	T3210	T3208	appos	19,11
R934	T3424	T3423	prep	on,Wg2
R935	T3425	T3424	pobj	MMU2,on
R936	T3426	T3423	punct	", ",Wg2
R937	T3211	T3212	punct	-,21
R938	T3427	T3423	conj	Carfhg2,Wg2
R939	T3428	T3427	prep	on,Carfhg2
R940	T3429	T3428	pobj	MMU9,on
R941	T3212	T3210	prep	21,19
R942	T3430	T3427	punct	", ",Carfhg2
R943	T3213	T3208	punct	],11
R944	T3214	T3182	punct	.,is
R945	T3431	T3427	conj	Carp2,Carfhg2
R946	T3216	T3217	nsubj	Epistasis,forms
R947	T3432	T3431	prep	on,Carp2
R948	T3433	T3432	pobj	MMU11,on
R949	T3434	T3431	cc	and,Carp2
R950	T3435	T3431	conj	Feml3,Carp2
R951	T3218	T3219	det	the,basis
R952	T3436	T3435	prep	on,Feml3
R953	T3437	T3436	pobj	MMU17,on
R954	T3438	T3419	punct	),QTL
R955	T3219	T3217	dobj	basis,forms
R961	T3444	T3442	pobj	QTL,with
R962	T3445	T3444	amod	additional,QTL
R963	T3537	T3536	prep	of,outside
R964	T3446	T3444	punct	(,QTL
R965	T3447	T3444	appos	Q1Ucd1,QTL
R966	T3448	T3447	prep	on,Q1Ucd1
R967	T3538	T3537	pobj	MMU2,of
R968	T3449	T3448	pobj	MMU1,on
R969	T3450	T3444	punct	(,QTL
R970	T3539	T3526	punct	", ",created
R971	T3451	T3452	dep	which,reached
R972	T3452	T3444	relcl	reached,QTL
R973	T3453	T3452	advmod	only,reached
R974	T3540	T3541	mark	while,developed
R975	T3454	T3455	det	a,level
R976	T3455	T3452	dobj	level,reached
R977	T3456	T3455	amod	suggestive,level
R978	T3541	T3526	advcl	developed,created
R979	T3457	T3455	prep	of,level
R980	T3458	T3459	amod	statistical,significance
R981	T3459	T3457	pobj	significance,of
R982	T3460	T3444	punct	),QTL
R983	T3542	T3543	det	a,panel
R984	T3461	T3444	punct	", ",QTL
R985	T3462	T3444	appos	Wg1,QTL
R986	T3543	T3541	nsubjpass	panel,developed
R987	T3463	T3462	punct	", ",Wg1
R988	T3464	T3462	conj	Carp1,Wg1
R989	T3465	T3464	punct	", ",Carp1
R990	T3544	T3543	amod	comprehensive,panel
R991	T3466	T3464	conj	Cara1,Carp1
R992	T3467	T3466	cc	and,Cara1
R993	T3468	T3466	conj	Feml1,Cara1
R994	T3545	T3543	prep	of,panel
R995	T3469	T3466	prep	on,Cara1
R996	T3470	T3469	pobj	MMU2,on
R997	T3471	T3466	punct	", ",Cara1
R998	T3546	T3547	amod	overlapping,strains
R999	T3472	T3466	conj	Carfhg1,Cara1
R1000	T3473	T3472	prep	on,Carfhg1
R1001	T3474	T3473	pobj	MMU5,on
R1002	T3547	T3545	pobj	strains,of
R1003	T3475	T3472	punct	", ",Carfhg1
R1004	T3476	T3472	conj	Wg3,Carfhg1
R1005	T3477	T3476	prep	on,Wg3
R1006	T3548	T3547	prep	with,strains
R1007	T3478	T3477	pobj	MMU8,on
R1008	T3479	T3476	punct	", ",Wg3
R1009	T3480	T3476	conj	Feml2,Wg3
R1010	T3481	T3480	prep	on,Feml2
R1011	T3482	T3481	pobj	MMU9,on
R1012	T3483	T3480	punct	", ",Feml2
R1013	T3549	T3550	amod	identical,regions
R1014	T3484	T3480	conj	Wg4,Feml2
R1015	T3485	T3484	cc	and,Wg4
R1016	T3486	T3484	conj	Cara2,Wg4
R1017	T3550	T3548	pobj	regions,with
R1018	T3487	T3484	prep	on,Wg4
R1019	T3488	T3487	pobj	MMU11,on
R1020	T3489	T3484	cc	and,Wg4
R1021	T3490	T3484	conj	Carp3,Wg4
R1022	T3551	T3550	compound	donor,regions
R1023	T3491	T3490	cc	and,Carp3
R1024	T3492	T3490	conj	Cara3,Carp3
R1025	T3552	T3543	prep	on,panel
R1026	T3493	T3490	prep	on,Carp3
R1027	T3494	T3493	pobj	MMU17,on
R1028	T3495	T3490	punct	),Carp3
R1029	T3553	T3554	preconj	both,B6
R1030	T3554	T3555	nmod	B6,backgrounds
R1031	T3496	T3497	poss	whose,expression
R1032	T3555	T3552	pobj	backgrounds,on
R1033	T3497	T3498	dep	expression,was
R1034	T3498	T3490	relcl	was,Carp3
R1035	T3499	T3498	acomp	independent,was
R1036	T3556	T3554	cc	and,B6
R1037	T3500	T3499	prep	of,independent
R1038	T3501	T3502	det	the,locus
R1039	T3502	T3500	pobj	locus,of
R1040	T3557	T3554	conj	HG,B6
R1041	T3503	T3502	compound	hg,locus
R1042	T3504	T3421	punct	.,identified
R1043	T3558	T3541	auxpass	were,developed
R1044	T3506	T3507	prep	In,developed
R1045	T3559	T3541	prep	for,developed
R1046	T3508	T3509	det	the,study
R1047	T3509	T3506	pobj	study,In
R1048	T3510	T3509	amod	current,study
R1049	T3511	T3507	nsubj	we,developed
R1050	T3560	T3559	pobj	MMU2,for
R1051	T3512	T3507	aux	have,developed
R1052	T3513	T3514	npadvmod	speed,congenic
R1053	T3514	T3515	amod	congenic,strains
R1054	T3561	T3526	punct	.,created
R1055	T3515	T3507	dobj	strains,developed
R1056	T3516	T3517	aux	to,isolate
R1057	T3517	T3507	advcl	isolate,developed
R1058	T3563	T3564	det	The,panel
R1059	T3518	T3519	predet	all,QTL
R1060	T3519	T3517	dobj	QTL,isolate
R1061	T3520	T3519	det	the,QTL
R1062	T3521	T3519	amod	aforementioned,QTL
R1063	T3522	T3507	punct	.,developed
R1064	T3524	T3525	amod	Single,strains
R1065	T3564	T3566	nsubjpass	panel,developed
R1066	T3525	T3526	nsubjpass	strains,created
R1067	T3527	T3525	prep	on,strains
R1068	T3565	T3564	compound	MMU2,panel
R1069	T3528	T3529	det	an,background
R1070	T3529	T3527	pobj	background,on
R1071	T3530	T3529	compound	HG,background
R1072	T3567	T3566	auxpass	was,developed
R1073	T3531	T3526	auxpass	were,created
R1074	T3532	T3526	prep	for,created
R1075	T3568	T3569	aux	to,confirm
R1076	T3533	T3534	det	each,region
R1077	T3569	T3566	advcl	confirm,developed
R1078	T3534	T3532	pobj	region,for
R1079	T3535	T3534	amod	chromosomal,region
R1080	T3536	T3534	prep	outside,region
R1090	T3579	T3581	compound	hg,interactions
R1091	T3580	T3579	punct	-,hg
R1102	T3593	T3591	pobj	interactions,of
R1103	T3594	T3595	compound	QTL,hg
R1105	T3596	T3595	punct	-,hg
R1114	T3605	T3607	dep	location,overlapped
R1115	T3606	T3605	amod	genomic,location
R1118	T3609	T3607	dobj	QTL,overlapped
R1119	T3610	T3609	compound	modifier,QTL
R1136	T4086	T4089	nsubjpass	panels,created
R1137	T4087	T4088	npadvmod	speed,congenic
R1138	T4088	T4086	amod	congenic,panels
R1143	T4094	T4089	advcl	dissected,created
R1144	T4095	T4094	advmod	comprehensively,dissected
R1147	T4098	T4094	advcl	isolated,dissected
R1148	T4099	T4100	det	the,second
R1149	T4100	T4098	nsubj	second,isolated
R1170	T4122	T4124	nsubj	panel,consisted
R1171	T4123	T4122	compound	MMU2,panel
R1174	T4127	T4125	pobj	strains,of
R1175	T4128	T4127	amod	congenic,strains
R1180	T4133	T4131	dobj	regions,introgressing
R1181	T4134	T4133	amod	overlapping,regions
R1182	T4135	T4133	compound	donor,regions
R1186	T4139	T4136	pobj	backgrounds,onto
R1187	T4140	T4138	cc	and,B6
R1188	T4141	T4138	conj	HG,B6
R1189	T4142	T4139	amod	genetic,backgrounds
R1196	T4150	T4152	nsubjpass	regions,created
R1197	T4151	T4150	compound	donor,regions
R1201	T4156	T4154	pobj	background,onto
R1202	T4157	T4156	compound	HG,background
R1207	T4162	T4160	dobj	QTL,isolate
R1208	T4163	T4162	amod	remaining,QTL
R1226	T4183	T4181	pobj	approach,of
R1227	T4184	T4185	npadvmod	speed,congenic
R1228	T4185	T4183	amod	congenic,approach
R1231	T4188	T4190	amod	assisted,breeding
R1232	T4189	T4188	punct	-,assisted
R1236	T4193	T4191	pobj	markers,with
R1237	T4194	T4195	npadvmod	genome,wide
R1239	T4196	T4195	punct	-,wide
R1240	T4197	T4193	compound	microsatellite,markers
R1246	T4203	T4180	parataxis	6,accelerated
R1247	T4204	T4203	nummod	5,6
R1248	T4205	T4203	punct	",",6
R1251	T4208	T4180	parataxis	File,accelerated
R1252	T4209	T4208	amod	Additional,File
R1277	T4238	T4236	pobj	panels,to
R1278	T4239	T4238	amod	congenic,panels
R1281	T4242	T4234	nsubjpass	strains,developed
R1282	T4243	T4242	compound	control,strains
R1287	T4248	T4245	appos	B6C,B6
R1288	T4249	T4248	punct	;,B6C
R1294	T4255	T4252	appos	HGC,HG
R1295	T4256	T4255	punct	;,HGC
R1299	T4260	T4258	pobj	markers,for
R1300	T4261	T4262	npadvmod	genome,wide
R1302	T4263	T4262	punct	-,wide
R1307	T4268	T4266	pobj	cross,from
R1308	T4269	T4268	amod	same,cross
R1328	T4291	T4285	nsubjpass	14,characterized
R1329	T4292	T4291	quantmod	of,14
R1338	T4302	T4306	nsubjpass	strains,characterized
R1339	T4303	T4302	nmod	HG2D,strains
R1340	T4304	T4303	cc	and,HG2D
R1341	T4305	T4303	conj	HG5,HG2D
R1350	T4316	T4319	nsubjpass	points,refined
R1351	T4317	T4316	amod	recombinant,points
R1352	T4318	T4316	compound	end,points
R1362	T4329	T4327	dobj	region,flanking
R1363	T4330	T4329	compound	donor,region
R1365	T4332	T4319	parataxis	File,refined
R1366	T4333	T4332	amod	Additional,File
R1378	T6950	T6951	nmod	MMU2,strain
R1379	T6951	T6954	compound	strain,characterization
R1380	T6952	T6953	npadvmod	speed,congenic
R1381	T6953	T6951	amod	congenic,strain
R1382	T6956	T6957	prep	Due,queried
R1383	T6958	T6956	pcomp	to,Due
R1384	T6959	T6960	det	the,nature
R1385	T6960	T6956	pobj	nature,Due
R1386	T6961	T6960	amod	overlapping,nature
R1387	T6962	T6960	prep	of,nature
R1388	T6963	T6964	det	the,congenics
R1389	T6964	T6962	pobj	congenics,of
R1390	T6965	T6964	compound	MMU2,congenics
R1391	T6966	T6957	punct	", ",queried
R1392	T6967	T6968	nummod	five,regions
R1393	T6968	T6957	nsubjpass	regions,queried
R1394	T6969	T6968	amod	distinct,regions
R1395	T6970	T6968	amod	chromosomal,regions
R1396	T6971	T6968	punct	(,regions
R1397	T6972	T6973	nmod	Regions,I
R1398	T6973	T6968	appos	I,regions
R1399	T6974	T6975	punct	–,V
R1400	T7033	T7013	punct	.,describe
R1401	T6975	T6973	prep	V,I
R1402	T7035	T7036	nmod	B6.CAST,MMU2
R1403	T6976	T6957	punct	),queried
R1404	T7036	T7037	nmod	MMU2,strains
R1405	T6977	T6957	auxpass	were,queried
R1406	T7038	T7039	npadvmod	speed,congenic
R1407	T7039	T7037	amod	congenic,strains
R1408	T6978	T6957	prep	for,queried
R1409	T7041	T7042	det	The,strain
R1410	T7042	T7044	nsubj	strain,exhibited
R1411	T6979	T6980	det	the,presence
R1412	T7043	T7042	compound	B62D,strain
R1413	T7045	T7046	det	the,decreases
R1414	T6980	T6978	pobj	presence,for
R1415	T7046	T7044	dobj	decreases,exhibited
R1416	T7047	T7046	amod	largest,decreases
R1417	T6981	T6980	prep	of,presence
R1418	T7048	T7049	punct	(,0.0001
R1419	T7049	T7047	parataxis	0.0001,largest
R1420	T7050	T7049	nsubj	P,0.0001
R1421	T7051	T7049	punct	<,0.0001
R1422	T7052	T7049	punct	),0.0001
R1423	T7053	T7046	prep	in,decreases
R1424	T7054	T7055	compound	body,weight
R1425	T7055	T7053	pobj	weight,in
R1426	T7056	T7046	prep	of,decreases
R1427	T7057	T7058	det	any,B6.CAST
R1428	T7058	T7056	pobj	B6.CAST,of
R1429	T6982	T6981	pobj	QTL,of
R1430	T7059	T7058	amod	congenic,B6.CAST
R1431	T7060	T7061	punct	(,File
R1432	T7061	T7044	parataxis	File,exhibited
R1433	T7062	T7061	amod	Additional,File
R1434	T6983	T6984	punct	(,Figure
R1435	T7063	T7061	nummod	3,File
R1436	T7064	T7061	punct	),File
R1437	T6984	T6957	parataxis	Figure,queried
R1438	T7065	T7044	punct	.,exhibited
R1439	T7067	T7068	det	Both,sexes
R1440	T6985	T6984	nummod	2,Figure
R1441	T6986	T6984	punct	),Figure
R1442	T7068	T7069	nsubj	sexes,had
R1443	T7070	T7069	dobj	reductions,had
R1444	T7071	T7070	prep	in,reductions
R1445	T6987	T6957	punct	.,queried
R1446	T7072	T7071	pobj	weight,in
R1447	T7073	T7070	prep	at,reductions
R1448	T7074	T7075	nummod	2,weeks
R1449	T6989	T6990	prep	As,tested
R1450	T7075	T7073	pobj	weeks,at
R1451	T7076	T7074	punct	(,2
R1452	T7077	T7074	appos	2WK,2
R1453	T7078	T7074	punct	),2
R1454	T6991	T6992	det	a,analysis
R1455	T7079	T7074	punct	", ",2
R1456	T7080	T7074	conj	3,2
R1457	T7081	T7080	punct	(,3
R1458	T6992	T6989	pobj	analysis,As
R1459	T7082	T7080	appos	3WK,3
R1460	T7083	T7080	punct	),3
R1461	T7084	T7080	punct	", ",3
R1462	T6993	T6992	amod	separate,analysis
R1463	T7085	T7080	conj	6,3
R1464	T7086	T7085	punct	(,6
R1465	T6994	T6990	nsubj	we,tested
R1466	T7087	T7085	appos	6WK,6
R1467	T7088	T7085	punct	),6
R1468	T7089	T7085	cc	and,6
R1469	T7090	T7085	conj	9,6
R1470	T6995	T6990	advmod	also,tested
R1471	T7091	T7090	punct	(,9
R1472	T7092	T7090	appos	9WK,9
R1473	T7093	T7075	punct	),weeks
R1474	T7094	T7075	prep	of,weeks
R1475	T7095	T7094	pobj	age,of
R1476	T7096	T7069	prep	compared,had
R1477	T6996	T6990	prep	for,tested
R1478	T7097	T7096	prep	to,compared
R1479	T6997	T6996	pobj	interactions,for
R1480	T6998	T6997	prep	between,interactions
R1481	T7098	T7099	compound	control,mice
R1482	T7099	T7097	pobj	mice,to
R1483	T6999	T7000	det	each,region
R1484	T7100	T7099	compound	B6C,mice
R1485	T7101	T7102	punct	(,Figure
R1486	T7000	T6998	pobj	region,between
R1487	T7102	T7069	parataxis	Figure,had
R1488	T7103	T7102	nummod	3,Figure
R1489	T7104	T7102	punct	),Figure
R1490	T7001	T7000	compound	donor,region
R1491	T7105	T7069	punct	.,had
R1492	T7107	T7108	prep	Despite,observed
R1493	T7002	T7000	cc	and,region
R1494	T7109	T7110	amod	large,decreases
R1495	T7003	T7004	det	the,backgrounds
R1496	T7110	T7107	pobj	decreases,Despite
R1497	T7004	T7000	conj	backgrounds,region
R1498	T7111	T7110	prep	in,decreases
R1499	T7112	T7113	compound	body,weight
R1500	T7113	T7111	pobj	weight,in
R1501	T7005	T7004	nummod	two,backgrounds
R1502	T7114	T7108	punct	", ",observed
R1503	T7115	T7116	det	no,differences
R1504	T7116	T7108	nsubjpass	differences,observed
R1505	T7117	T7116	prep	in,differences
R1506	T7006	T7004	amod	distinct,backgrounds
R1507	T7118	T7119	compound	growth,rates
R1508	T7119	T7117	pobj	rates,in
R1509	T7120	T7121	punct	(,gain
R1510	T7007	T7004	amod	genetic,backgrounds
R1511	T7121	T7116	parataxis	gain,differences
R1512	T7122	T7121	dep	G26,gain
R1513	T7123	T7121	punct	", ",gain
R1514	T7008	T6990	punct	.,tested
R1515	T7124	T7121	compound	weight,gain
R1516	T7125	T7121	prep	from,gain
R1517	T7126	T7127	quantmod	2,6
R1518	T7010	T7011	det	The,sections
R1519	T7127	T7129	nummod	6,weeks
R1520	T7128	T7127	quantmod	to,6
R1521	T7129	T7125	pobj	weeks,from
R1522	T7130	T7121	cc	and,gain
R1523	T7011	T7013	nsubj	sections,describe
R1524	T7131	T7132	dep	G29,gain
R1525	T7132	T7121	conj	gain,gain
R1526	T7133	T7132	punct	", ",gain
R1527	T7134	T7132	compound	weight,gain
R1528	T7135	T7132	prep	from,gain
R1529	T7136	T7137	quantmod	2,9
R1530	T7012	T7011	amod	following,sections
R1531	T7137	T7139	nummod	9,weeks
R1532	T7014	T7015	det	the,phenotypes
R1533	T7015	T7013	dobj	phenotypes,describe
R1534	T7138	T7137	quantmod	to,9
R1535	T7016	T7015	prep	for,phenotypes
R1536	T7139	T7135	pobj	weeks,from
R1537	T7140	T7132	punct	),gain
R1538	T7141	T7108	auxpass	were,observed
R1539	T7017	T7018	det	each,strain
R1540	T7142	T7143	punct	(,File
R1541	T7143	T7108	parataxis	File,observed
R1542	T7144	T7143	amod	Additional,File
R1543	T7018	T7016	pobj	strain,for
R1544	T7145	T7143	nummod	3,File
R1545	T7146	T7143	punct	),File
R1546	T7147	T7108	punct	.,observed
R1547	T7019	T7018	nmod	B6.CAST,strain
R1548	T7149	T7150	advmod	Therefore,harbors
R1549	T7020	T7019	cc	and,B6.CAST
R1550	T7021	T7019	conj	HG.CAST,B6.CAST
R1551	T7151	T7150	punct	", ",harbors
R1552	T7152	T7153	det	the,region
R1553	T7153	T7150	nsubj	region,harbors
R1554	T7154	T7153	nmod	B62D,region
R1555	T7022	T7023	npadvmod	speed,congenic
R1556	T7155	T7153	amod	unique,region
R1557	T7156	T7153	punct	(,region
R1558	T7157	T7153	appos	Region,region
R1559	T7023	T7018	amod	congenic,strain
R1560	T7158	T7157	nummod	V,Region
R1561	T7159	T7150	punct	),harbors
R1562	T7160	T7161	preconj	either,QTL
R1563	T7024	T7025	advmod	as,as
R1564	T7161	T7150	dobj	QTL,harbors
R1565	T7162	T7161	det	an,QTL
R1566	T7163	T7164	amod	early,growth
R1567	T7025	T7015	cc	as,phenotypes
R1568	T7164	T7161	compound	growth,QTL
R1569	T7165	T7164	punct	-,growth
R1570	T7026	T7025	advmod	well,as
R1571	T7166	T7161	cc	or,QTL
R1572	T7167	T7168	amod	maternal,effect
R1573	T7168	T7161	conj	effect,QTL
R1574	T7027	T7028	det	the,results
R1575	T7169	T7168	compound	genotype,effect
R1576	T7170	T7171	dep	which,produces
R1577	T7171	T7168	relcl	produces,effect
R1578	T7172	T7173	det	a,decrease
R1579	T7173	T7171	dobj	decrease,produces
R1580	T7174	T7173	amod	distinct,decrease
R1581	T7028	T7015	conj	results,phenotypes
R1582	T7175	T7173	prep	in,decrease
R1583	T7176	T7177	compound	body,weight
R1584	T7177	T7175	pobj	weight,in
R1585	T7178	T7179	amod	prior,to
R1586	T7029	T7028	prep	of,results
R1587	T7179	T7171	prep	to,produces
R1588	T7180	T7179	pobj	2WK,to
R1589	T7030	T7031	det	the,analysis
R1590	T7181	T7150	punct	.,harbors
R1591	T7031	T7029	pobj	analysis,of
R1592	T7183	T7184	det	These,effects
R1593	T7032	T7031	compound	interaction,analysis
R1594	T7184	T7185	nsubj	effects,are
R1595	T7243	T7244	nsubj	9WK,was
R1596	T7186	T7185	acomp	evident,are
R1597	T7187	T7185	prep	in,are
R1598	T7188	T7189	det	the,curves
R1599	T7189	T7187	pobj	curves,in
R1600	T7190	T7189	compound	growth,curves
R1601	T7244	T7241	ccomp	was,were
R1602	T7191	T7189	prep	for,curves
R1603	T7192	T7193	det	both,sexes
R1604	T7245	T7244	acomp	significant,was
R1605	T7193	T7191	pobj	sexes,for
R1606	T7194	T7193	prep	of,sexes
R1607	T7246	T7241	punct	", ",were
R1608	T7195	T7196	det	each,strain
R1609	T7196	T7194	pobj	strain,of
R1610	T7247	T7248	amod	female,6WK
R1611	T7197	T7198	punct	(,Figure
R1612	T7198	T7185	parataxis	Figure,are
R1613	T7199	T7198	nummod	3,Figure
R1614	T7248	T7241	nsubj	6WK,were
R1615	T7200	T7198	punct	),Figure
R1616	T7201	T7185	punct	.,are
R1617	T7249	T7248	cc	and,6WK
R1618	T7203	T7204	advmod	Additionally,displayed
R1619	T7250	T7248	conj	9WK,6WK
R1620	T7205	T7204	punct	", ",displayed
R1621	T7206	T7207	compound	B62D,mice
R1622	T7207	T7204	nsubj	mice,displayed
R1623	T7251	T7241	acomp	suggestive,were
R1624	T7208	T7209	advmod	significantly,shorter
R1625	T7209	T7210	amod	shorter,lengths
R1626	T7210	T7204	dobj	lengths,displayed
R1627	T7252	T7241	prep	at,were
R1628	T7211	T7210	compound	tail,lengths
R1629	T7212	T7204	prep	despite,displayed
R1630	T7213	T7214	det	no,difference
R1631	T7214	T7212	pobj	difference,despite
R1632	T7215	T7214	prep	in,difference
R1633	T7216	T7217	amod	naso-anal,length
R1634	T7253	T7254	nsubj	P,0.05
R1635	T7217	T7215	pobj	length,in
R1636	T7218	T7217	punct	(,length
R1637	T7219	T7217	appos	NA,length
R1638	T7220	T7204	punct	),displayed
R1639	T7254	T7252	pcomp	0.05,at
R1640	T7221	T7222	punct	(,Table
R1641	T7222	T7204	parataxis	Table,displayed
R1642	T7223	T7222	nummod	2,Table
R1643	T7255	T7254	punct	<,0.05
R1644	T7224	T7222	punct	),Table
R1645	T7225	T7204	punct	.,displayed
R1646	T7256	T7241	punct	),were
R1647	T7227	T7228	prep	In,displayed
R1648	T7257	T7234	cc	and,decreases
R1649	T7229	T7227	pobj	contrast,In
R1650	T7230	T7228	punct	", ",displayed
R1651	T7231	T7232	compound	B62M,mice
R1652	T7232	T7228	nsubj	mice,displayed
R1653	T7258	T7259	amod	significant,decreases
R1654	T7233	T7234	amod	small,decreases
R1655	T7234	T7228	dobj	decreases,displayed
R1657	T7235	T7234	prep	in,decreases
R1658	T7236	T7237	compound	body,weights
R1659	T7260	T7259	prep	in,decreases
R1660	T7237	T7235	pobj	weights,in
R1661	T7238	T7237	cc	and,weights
R1662	T7239	T7237	conj	growth,weights
R1663	T7240	T7241	punct	(,were
R1664	T7261	T7262	nmod	NA,length
R1665	T7241	T7234	parataxis	were,decreases
R1666	T7242	T7243	amod	male,9WK
R1668	T7263	T7264	punct	(,0.0152
R1669	T7264	T7261	parataxis	0.0152,NA
R1670	T7349	T7350	compound	tail,length
R1671	T7350	T7347	conj	length,weight
R1672	T7351	T7350	punct	", ",length
R1673	T7265	T7266	amod	male,P
R1674	T7352	T7350	cc	but,length
R1675	T7353	T7352	neg	not,but
R1676	T7354	T7350	conj	NA,length
R1677	T7266	T7264	nsubj	P,0.0152
R1678	T7355	T7333	punct	.,disjoined
R1679	T7267	T7264	punct	=,0.0152
R1680	T7357	T7358	det	The,QTL
R1681	T7358	T7360	nsubj	QTL,increases
R1682	T7359	T7358	amod	third,QTL
R1683	T7268	T7264	punct	),0.0152
R1684	T7361	T7358	punct	", ",QTL
R1685	T7362	T7358	acl	located,QTL
R1686	T7269	T7261	cc	and,NA
R1687	T7363	T7362	prep	within,located
R1688	T7364	T7365	det	the,region
R1689	T7270	T7261	conj	tail,NA
R1690	T7365	T7363	pobj	region,within
R1691	T7366	T7365	nmod	B62D,region
R1692	T7367	T7365	amod	unique,region
R1693	T7271	T7272	punct	(,File
R1694	T7368	T7365	punct	(,region
R1695	T7369	T7365	appos	Region,region
R1696	T7272	T7228	parataxis	File,displayed
R1697	T7370	T7369	nummod	V,Region
R1698	T7371	T7360	punct	),increases
R1699	T7372	T7360	punct	", ",increases
R1700	T7373	T7360	dobj	NA,increases
R1701	T7273	T7272	amod	Additional,File
R1702	T7374	T7360	advcl	canceling,increases
R1703	T7375	T7376	det	the,effects
R1704	T7274	T7272	nummod	3,File
R1705	T7376	T7374	dobj	effects,canceling
R1706	T7377	T7376	prep	of,effects
R1707	T7378	T7379	det	the,QTL
R1708	T7275	T7272	cc	and,File
R1709	T7379	T7381	nsubj	QTL,decreasing
R1710	T7380	T7379	compound	B62M,QTL
R1711	T7381	T7377	pcomp	decreasing,of
R1712	T7276	T7272	conj	Table,File
R1713	T7382	T7383	punct	(,Region
R1714	T7383	T7379	parataxis	Region,QTL
R1715	T7277	T7276	nummod	2,Table
R1716	T7384	T7383	nummod	IV,Region
R1717	T7385	T7383	punct	),Region
R1718	T7278	T7272	punct	),File
R1719	T7386	T7381	dobj	NA,decreasing
R1720	T7279	T7228	punct	.,displayed
R1721	T7387	T7360	punct	.,increases
R1722	T7281	T7282	det	The,decrease
R1723	T7389	T7390	compound	B62PM,females
R1724	T7390	T7391	nsubj	females,had
R1725	T7282	T7283	nsubj	decrease,is
R1726	T7392	T7391	dobj	decreases,had
R1727	T7393	T7392	prep	in,decreases
R1728	T7394	T7395	det	all,traits
R1729	T7284	T7282	prep	in,decrease
R1730	T7395	T7393	pobj	traits,in
R1731	T7396	T7397	npadvmod	growth,related
R1732	T7397	T7395	amod	related,traits
R1733	T7398	T7397	punct	-,related
R1734	T7399	T7395	prep	except,traits
R1735	T7400	T7399	pobj	2WK,except
R1736	T7401	T7400	cc	and,2WK
R1737	T7285	T7284	pobj	NA,in
R1738	T7402	T7400	conj	3WK,2WK
R1739	T7403	T7391	punct	", ",had
R1740	T7404	T7405	mark	while,seen
R1741	T7405	T7391	advcl	seen,had
R1742	T7286	T7282	prep	in,decrease
R1743	T7406	T7407	det	no,differences
R1744	T7407	T7405	nsubjpass	differences,seen
R1745	T7408	T7405	auxpass	were,seen
R1746	T7287	T7288	compound	B62M,mice
R1747	T7409	T7405	prep	in,seen
R1748	T7410	T7409	pobj	males,in
R1749	T7288	T7286	pobj	mice,in
R1750	T7411	T7412	punct	(,File
R1751	T7412	T7391	parataxis	File,had
R1752	T7413	T7412	amod	Additional,File
R1753	T7289	T7283	acomp	surprising,is
R1754	T7414	T7412	nummod	3,File
R1755	T7415	T7412	punct	),File
R1756	T7416	T7391	punct	.,had
R1757	T7290	T7291	mark	since,nested
R1758	T7418	T7419	advmod	Similarly,showed
R1759	T7291	T7283	advcl	nested,is
R1760	T7420	T7419	punct	", ",showed
R1761	T7421	T7422	advmod	only,females
R1762	T7292	T7293	det	the,region
R1763	T7422	T7419	nsubj	females,showed
R1764	T7423	T7422	compound	B62P,females
R1765	T7424	T7422	cc	and,females
R1766	T7293	T7291	nsubjpass	region,nested
R1767	T7425	T7424	neg	not,and
R1768	T7294	T7293	compound	2M,region
R1769	T7426	T7422	conj	males,females
R1770	T7427	T7428	amod	significant,decreases
R1771	T7428	T7419	dobj	decreases,showed
R1772	T7429	T7428	prep	in,decreases
R1773	T7430	T7429	pobj	9WK,in
R1774	T7295	T7293	compound	donor,region
R1775	T7431	T7430	punct	", ",9WK
R1776	T7432	T7430	conj	G26,9WK
R1777	T7296	T7291	auxpass	is,nested
R1778	T7433	T7432	cc	and,G26
R1779	T7434	T7432	conj	G29,G26
R1780	T7435	T7436	punct	(,File
R1781	T7297	T7291	advmod	entirely,nested
R1782	T7436	T7419	parataxis	File,showed
R1783	T7437	T7436	amod	Additional,File
R1784	T7438	T7436	nummod	3,File
R1785	T7439	T7436	punct	),File
R1786	T7440	T7419	punct	", ",showed
R1787	T7441	T7419	advcl	indicating,showed
R1788	T7298	T7291	prep	within,nested
R1789	T7442	T7443	det	these,strains
R1790	T7299	T7300	det	the,region
R1791	T7443	T7445	nsubj	strains,share
R1792	T7444	T7443	nummod	two,strains
R1793	T7300	T7298	pobj	region,within
R1794	T7445	T7441	advcl	share,indicating
R1795	T7446	T7447	det	a,QTL
R1796	T7301	T7300	compound	2D,region
R1797	T7447	T7445	dobj	QTL,share
R1798	T7448	T7449	amod	female,specific
R1799	T7449	T7447	amod	specific,QTL
R1800	T7302	T7300	compound	donor,region
R1801	T7450	T7447	compound	growth,QTL
R1802	T7451	T7452	punct	(,Region
R1803	T7303	T7291	cc	and,nested
R1804	T7452	T7445	parataxis	Region,share
R1805	T7453	T7452	nummod	II,Region
R1806	T7454	T7452	punct	),Region
R1807	T7304	T7305	compound	B62D,mice
R1808	T7305	T7306	nsubj	mice,showed
R1809	T7306	T7291	conj	showed,nested
R1810	T7455	T7419	punct	.,showed
R1811	T7307	T7308	det	no,difference
R1812	T7457	T7458	prep	In,linked
R1813	T7308	T7306	dobj	difference,showed
R1814	T7459	T7460	det	the,scan
R1815	T7460	T7457	pobj	scan,In
R1816	T7309	T7308	prep	in,difference
R1817	T7461	T7460	amod	original,scan
R1818	T7462	T7460	compound	genome,scan
R1819	T7463	T7464	compound	body,fat
R1820	T7310	T7309	pobj	NA,in
R1821	T7464	T7465	compound	fat,percentage
R1822	T7465	T7458	nsubjpass	percentage,linked
R1823	T7311	T7312	punct	(,Figure
R1824	T7466	T7467	mark	as,determined
R1825	T7467	T7465	advcl	determined,percentage
R1826	T7312	T7306	parataxis	Figure,showed
R1827	T7468	T7467	prep	by,determined
R1828	T7469	T7470	amod	chemical,analysis
R1829	T7470	T7468	pobj	analysis,by
R1830	T7313	T7312	nummod	2,Figure
R1831	T7471	T7470	amod	compositional,analysis
R1832	T7472	T7458	auxpass	was,linked
R1833	T7473	T7458	neg	not,linked
R1834	T7474	T7458	prep	to,linked
R1835	T7475	T7474	pobj	markers,to
R1836	T7476	T7475	prep	on,markers
R1837	T7477	T7476	pobj	MMU2,on
R1838	T7314	T7312	punct	),Figure
R1839	T7478	T7479	punct	[,24
R1840	T7479	T7458	parataxis	24,linked
R1841	T7480	T7479	punct	],24
R1842	T7481	T7458	punct	.,linked
R1843	T7315	T7283	punct	.,is
R1844	T7483	T7484	advmod	However,chose
R1845	T7317	T7318	det	These,data
R1846	T7485	T7484	punct	", ",chose
R1847	T7486	T7487	mark	since,found
R1848	T7487	T7484	advcl	found,chose
R1849	T7318	T7319	nsubj	data,indicate
R1850	T7488	T7489	amod	numerous,QTL
R1851	T7489	T7487	nsubjpass	QTL,found
R1852	T7490	T7489	compound	obesity,QTL
R1853	T7320	T7321	det	the,presence
R1854	T7491	T7487	aux	have,found
R1855	T7492	T7487	auxpass	been,found
R1856	T7493	T7487	prep	on,found
R1857	T7494	T7493	pobj	MMU2,on
R1858	T7495	T7496	punct	[,2
R1859	T7321	T7319	dobj	presence,indicate
R1860	T7496	T7487	parataxis	2,found
R1861	T7497	T7496	punct	],2
R1862	T7498	T7487	punct	", ",found
R1863	T7322	T7321	prep	of,presence
R1864	T7499	T7500	dep	some,discovered
R1865	T7500	T7487	advcl	discovered,found
R1866	T7323	T7324	nummod	three,QTL
R1867	T7501	T7499	prep	of,some
R1868	T7502	T7501	pobj	which,of
R1869	T7503	T7500	auxpass	were,discovered
R1870	T7324	T7322	pobj	QTL,of
R1871	T7504	T7500	prep	in,discovered
R1872	T7505	T7504	pobj	B6,in
R1873	T7506	T7500	prep	by,discovered
R1874	T7325	T7324	prep	with,QTL
R1875	T7507	T7508	compound	CAST,crosses
R1876	T7508	T7506	pobj	crosses,by
R1877	T7326	T7327	det	the,region
R1878	T7509	T7510	punct	[,25
R1879	T7510	T7500	parataxis	25,discovered
R1880	T7327	T7325	pobj	region,with
R1881	T7511	T7510	nummod	9,25
R1882	T7512	T7510	punct	",",25
R1883	T7513	T7510	punct	],25
R1884	T7328	T7327	nmod	2D,region
R1885	T7514	T7484	punct	", ",chose
R1886	T7515	T7484	nsubj	we,chose
R1887	T7516	T7517	aux	to,measure
R1888	T7517	T7484	xcomp	measure,chose
R1889	T7518	T7519	amod	dissected,weights
R1890	T7519	T7517	dobj	weights,measure
R1891	T7329	T7327	amod	unique,region
R1892	T7520	T7521	compound	fat,pad
R1893	T7521	T7519	compound	pad,weights
R1894	T7522	T7517	prep	as,measure
R1895	T7330	T7319	punct	.,indicate
R1896	T7523	T7524	det	a,measure
R1897	T7524	T7522	pobj	measure,as
R1898	T7525	T7526	advmod	more,sensitive
R1899	T7332	T7333	dep	Two,disjoined
R1900	T7526	T7524	amod	sensitive,measure
R1901	T7527	T7524	prep	of,measure
R1902	T7334	T7332	prep	of,Two
R1903	T7528	T7527	pobj	adiposity,of
R1904	T7529	T7484	punct	.,chose
R1905	T7335	T7334	pobj	which,of
R1906	T7531	T7532	nsubj	Table,lists
R1907	T7336	T7333	auxpass	are,disjoined
R1908	T7533	T7531	nummod	2,Table
R1909	T7534	T7535	det	the,weights
R1910	T7337	T7333	agent	by,disjoined
R1911	T7535	T7532	dobj	weights,lists
R1912	T7536	T7535	prep	of,weights
R1913	T7537	T7538	amod	gonadal,pads
R1914	T7338	T7339	det	the,strains
R1915	T7538	T7536	pobj	pads,of
R1916	T7339	T7337	pobj	strains,by
R1920	T7340	T7339	nmod	B62M,strains
R1921	T7542	T7537	punct	", ",gonadal
R1922	T7543	T7537	conj	femoral,gonadal
R1923	T7544	T7545	punct	(,FFP
R1924	T7341	T7340	cc	and,B62M
R1925	T7545	T7543	parataxis	FFP,femoral
R1926	T7546	T7545	punct	),FFP
R1927	T7547	T7543	punct	", ",femoral
R1928	T7548	T7543	conj	mesenteric,femoral
R1929	T7342	T7340	conj	B62D,B62M
R1930	T7549	T7550	punct	(,MFP
R1931	T7343	T7333	cc	and,disjoined
R1932	T7550	T7548	parataxis	MFP,mesenteric
R1933	T7551	T7550	punct	),MFP
R1934	T7552	T7548	cc	and,mesenteric
R1935	T7344	T7345	advmod	additively,decrease
R1936	T7553	T7548	conj	retroperitoneal,mesenteric
R1937	T7554	T7555	punct	(,RFP
R1938	T7555	T7553	parataxis	RFP,retroperitoneal
R1939	T7556	T7555	punct	),RFP
R1940	T7557	T7538	compound	fat,pads
R1941	T7558	T7532	punct	", ",lists
R1942	T7345	T7333	conj	decrease,disjoined
R1943	T7559	T7532	prep	along,lists
R1944	T7346	T7347	compound	body,weight
R1945	T7347	T7345	dobj	weight,decrease
R1946	T7348	T7347	cc	and,weight
R1947	T7560	T7559	prep	with,along
R1948	T7561	T7562	amod	total,weight
R1949	T7562	T7560	pobj	weight,with
R1950	T7666	T7665	auxpass	is,located
R1951	T7563	T7564	compound	fat,pad
R1952	T7564	T7562	compound	pad,weight
R1953	T7565	T7562	punct	(,weight
R1954	T7566	T7562	appos	sum,weight
R1955	T7567	T7566	prep	of,sum
R1956	T7667	T7665	prep	in,located
R1957	T7568	T7569	det	the,pads
R1958	T7569	T7567	pobj	pads,of
R1959	T7668	T7669	det	the,region
R1960	T7570	T7569	nummod	four,pads
R1961	T7571	T7569	compound	fat,pads
R1962	T7572	T7562	punct	),weight
R1963	T7573	T7562	punct	", ",weight
R1964	T7669	T7667	pobj	region,in
R1965	T7574	T7575	compound	adiposity,index
R1966	T7575	T7562	conj	index,weight
R1967	T7670	T7669	nmod	B62D,region
R1968	T7576	T7577	punct	(,WSAC
R1969	T7577	T7575	parataxis	WSAC,index
R1970	T7578	T7579	nsubj	AI,TF
R1971	T7579	T7577	ccomp	TF,WSAC
R1972	T7671	T7669	amod	unique,region
R1973	T7580	T7579	punct	=,TF
R1974	T7581	T7582	punct	/,weight
R1975	T7672	T7669	punct	(,region
R1976	T7582	T7579	prep	weight,TF
R1977	T7583	T7582	prep	at,weight
R1978	T7584	T7583	pobj	sacrifice,at
R1979	T7673	T7669	appos	Region,region
R1980	T7585	T7577	punct	(,WSAC
R1981	T7586	T7577	punct	),WSAC
R1982	T7587	T7577	punct	),WSAC
R1983	T7674	T7673	nummod	V,Region
R1984	T7588	T7575	cc	and,index
R1985	T7589	T7590	compound	body,index
R1986	T7590	T7575	conj	index,index
R1987	T7675	T7660	punct	),indicates
R1988	T7591	T7590	compound	mass,index
R1989	T7592	T7593	punct	(,WSAC
R1990	T7676	T7660	punct	.,indicates
R1991	T7593	T7590	parataxis	WSAC,index
R1992	T7594	T7593	nsubj	BMI,WSAC
R1993	T7595	T7593	punct	=,WSAC
R1994	T7596	T7597	punct	/,NA2
R1995	T7597	T7593	prep	NA2,WSAC
R1996	T7598	T7599	punct	*,100
R1997	T7678	T7679	advmod	Only,differences
R1998	T7599	T7597	acl	100,NA2
R1999	T7600	T7593	punct	),WSAC
R2000	T7601	T7532	prep	for,lists
R2001	T7602	T7603	det	each,strain
R2002	T7603	T7601	pobj	strain,for
R2003	T7679	T7681	nsubjpass	differences,observed
R2004	T7604	T7605	npadvmod	MMU2,congenic
R2005	T7605	T7603	amod	congenic,strain
R2006	T7606	T7532	punct	.,lists
R2007	T7680	T7679	amod	minor,differences
R2008	T7608	T7609	advcl	Similar,displayed
R2009	T7682	T7679	prep	in,differences
R2010	T7610	T7608	prep	to,Similar
R2011	T7611	T7612	amod	large,differences
R2012	T7612	T7610	pobj	differences,to
R2013	T7683	T7684	amod	various,weights
R2014	T7613	T7612	prep	in,differences
R2015	T7684	T7682	pobj	weights,in
R2016	T7614	T7615	compound	body,weight
R2017	T7615	T7613	pobj	weight,in
R2018	T7685	T7686	compound	fat,pad
R2019	T7616	T7617	det	the,strain
R2020	T7617	T7609	nsubj	strain,displayed
R2021	T7618	T7617	compound	B62D,strain
R2022	T7619	T7620	advmod	highly,significant
R2023	T7686	T7684	compound	pad,weights
R2024	T7620	T7621	amod	significant,decreases
R2025	T7621	T7609	dobj	decreases,displayed
R2026	T7687	T7681	auxpass	were,observed
R2027	T7622	T7621	prep	in,decreases
R2028	T7623	T7622	pobj	adiposity,in
R2029	T7624	T7609	punct	.,displayed
R2030	T7688	T7681	prep	for,observed
R2031	T7626	T7627	nsubj	B62D,was
R2032	T7689	T7690	det	the,strains
R2033	T7628	T7629	det	the,strain
R2034	T7629	T7627	attr	strain,was
R2035	T7690	T7688	pobj	strains,for
R2036	T7630	T7629	amod	only,strain
R2037	T7631	T7632	advmod	where,had
R2038	T7691	T7690	nmod	B62P,strains
R2039	T7632	T7629	relcl	had,strain
R2040	T7633	T7634	det	both,sexes
R2041	T7634	T7632	nsubj	sexes,had
R2042	T7692	T7691	cc	and,B62P
R2043	T7635	T7636	amod	significant,decreases
R2044	T7636	T7632	dobj	decreases,had
R2045	T7637	T7636	prep	in,decreases
R2046	T7638	T7637	pobj	TF,in
R2047	T7639	T7638	punct	", ",TF
R2048	T7640	T7638	conj	AI,TF
R2049	T7641	T7640	cc	and,AI
R2050	T7693	T7691	conj	B62PM,B62P
R2051	T7642	T7640	conj	BMI,AI
R2052	T7643	T7627	punct	.,was
R2053	T7694	T7695	punct	(,Table
R2054	T7645	T7646	advmod	Interestingly,seen
R2055	T7647	T7646	punct	", ",seen
R2056	T7695	T7681	parataxis	Table,observed
R2057	T7648	T7649	det	no,difference
R2058	T7649	T7646	nsubjpass	difference,seen
R2059	T7650	T7649	prep	in,difference
R2060	T7696	T7695	nummod	2,Table
R2061	T7651	T7650	pobj	adiposity,in
R2062	T7652	T7646	auxpass	was,seen
R2063	T7653	T7646	prep	in,seen
R2064	T7697	T7695	punct	),Table
R2065	T7654	T7655	compound	B62M,mice
R2066	T7655	T7653	pobj	mice,in
R2067	T7656	T7646	punct	.,seen
R2068	T7698	T7681	punct	.,observed
R2069	T7658	T7659	det	This,discordance
R2070	T7659	T7660	nsubj	discordance,indicates
R2071	T7700	T7701	nmod	HG.CAST,MMU2
R2072	T7661	T7662	det	the,QTL
R2073	T7662	T7665	nsubjpass	QTL,located
R2074	T7663	T7664	npadvmod	leanness,promoting
R2075	T7701	T7702	nmod	MMU2,panel
R2076	T7664	T7662	amod	promoting,QTL
R2077	T7665	T7660	advcl	located,indicates
R2078	T7703	T7704	npadvmod	speed,congenic
R2079	T7704	T7702	amod	congenic,panel
R2080	T7706	T7707	nmod	HG2P,mice
R2081	T7772	T7769	conj	gain,size
R2082	T7773	T7772	cc	and,gain
R2083	T7774	T7772	conj	NA,gain
R2084	T7707	T7710	nsubj	mice,displayed
R2085	T7775	T7774	punct	(,NA
R2086	T7776	T7777	advmod	only,in
R2087	T7708	T7706	cc	and,HG2P
R2088	T7777	T7774	prep	in,NA
R2089	T7778	T7777	pobj	females,in
R2090	T7779	T7757	punct	),decrease
R2091	T7709	T7706	conj	HG2PM,HG2P
R2092	T7711	T7707	prep	of,mice
R2093	T7780	T7757	punct	", ",decrease
R2094	T7781	T7782	mark	while,decreases
R2095	T7782	T7757	advcl	decreases,decrease
R2096	T7783	T7784	det	a,QTL
R2097	T7712	T7713	det	both,sexes
R2098	T7784	T7782	nsubj	QTL,decreases
R2099	T7785	T7784	prep	in,QTL
R2100	T7786	T7787	det	the,region
R2101	T7713	T7711	pobj	sexes,of
R2102	T7787	T7785	pobj	region,in
R2103	T7788	T7787	compound	HG2M,region
R2104	T7789	T7782	advmod	significantly,decreases
R2105	T7714	T7715	amod	significant,decreases
R2106	T7790	T7791	compound	tail,length
R2107	T7715	T7710	dobj	decreases,displayed
R2108	T7791	T7782	dobj	length,decreases
R2109	T7716	T7715	prep	in,decreases
R2110	T7792	T7755	punct	.,indicate
R2111	T7717	T7718	amod	post-weaning,weights
R2112	T7794	T7795	advcl	Similar,seen
R2113	T7718	T7716	pobj	weights,in
R2114	T7796	T7794	prep	to,Similar
R2115	T7797	T7798	compound	growth,traits
R2116	T7798	T7796	pobj	traits,to
R2117	T7719	T7718	compound	body,weights
R2118	T7799	T7800	det	a,decrease
R2119	T7800	T7795	nsubjpass	decrease,seen
R2120	T7801	T7800	amod	general,decrease
R2121	T7720	T7718	cc	and,weights
R2122	T7802	T7800	prep	in,decrease
R2123	T7803	T7802	pobj	GFP,in
R2124	T7721	T7722	compound	growth,rates
R2125	T7804	T7803	punct	", ",GFP
R2126	T7805	T7803	conj	MFP,GFP
R2127	T7806	T7805	punct	", ",MFP
R2128	T7722	T7718	conj	rates,weights
R2129	T7807	T7805	conj	RFP,MFP
R2130	T7808	T7807	punct	", ",RFP
R2131	T7723	T7724	punct	(,Table
R2132	T7809	T7807	conj	TF,RFP
R2133	T7810	T7809	cc	and,TF
R2134	T7811	T7809	conj	AI,TF
R2135	T7812	T7795	auxpass	were,seen
R2136	T7724	T7710	parataxis	Table,displayed
R2137	T7813	T7795	prep	in,seen
R2138	T7814	T7815	nmod	HG2P,mice
R2139	T7725	T7724	amod	Additional,Table
R2140	T7815	T7813	pobj	mice,in
R2141	T7816	T7814	cc	and,HG2P
R2142	T7817	T7814	conj	HG2PM,HG2P
R2143	T7726	T7724	nummod	3,Table
R2144	T7818	T7819	punct	(,Region
R2145	T7819	T7795	parataxis	Region,seen
R2146	T7820	T7819	nummod	II,Region
R2147	T7821	T7819	punct	),Region
R2148	T7822	T7823	punct	(,Table
R2149	T7727	T7724	punct	),Table
R2150	T7823	T7795	parataxis	Table,seen
R2151	T7824	T7823	nummod	2,Table
R2152	T7825	T7823	punct	),Table
R2153	T7728	T7710	punct	.,displayed
R2154	T7826	T7795	punct	.,seen
R2155	T7828	T7829	det	These,differences
R2156	T7730	T7731	prep	In,displayed
R2157	T7829	T7830	nsubj	differences,are
R2158	T7831	T7829	prep	in,differences
R2159	T7832	T7831	pobj	adiposity,in
R2160	T7732	T7730	pobj	addition,In
R2161	T7833	T7830	advmod	likely,are
R2162	T7834	T7835	amod	pleiotropic,effects
R2163	T7835	T7830	attr	effects,are
R2164	T7836	T7835	prep	of,effects
R2165	T7733	T7731	punct	", ",displayed
R2166	T7837	T7838	det	the,QTL
R2167	T7838	T7836	pobj	QTL,of
R2168	T7734	T7735	det	the,strain
R2169	T7839	T7838	compound	growth,QTL
R2170	T7840	T7838	acl	shared,QTL
R2171	T7841	T7840	prep	between,shared
R2172	T7842	T7843	det	these,strains
R2173	T7735	T7731	nsubj	strain,displayed
R2174	T7843	T7841	pobj	strains,between
R2175	T7844	T7843	nummod	two,strains
R2176	T7736	T7735	compound	HG2M,strain
R2177	T7845	T7830	punct	.,are
R2178	T7847	T7848	advmod	Surprisingly,displayed
R2179	T7737	T7738	advmod	highly,significant
R2180	T7849	T7848	punct	", ",displayed
R2181	T7850	T7851	compound	HG2M,mice
R2182	T7738	T7739	amod	significant,decreases
R2183	T7851	T7848	nsubj	mice,displayed
R2184	T7852	T7853	amod	striking,differences
R2185	T7739	T7731	dobj	decreases,displayed
R2186	T7853	T7848	dobj	differences,displayed
R2187	T7854	T7853	compound	sex,differences
R2188	T7855	T7853	prep	in,differences
R2189	T7856	T7855	pobj	adiposity,in
R2190	T7740	T7739	prep	in,decreases
R2191	T7857	T7848	punct	.,displayed
R2192	T7741	T7740	pobj	length,in
R2193	T7859	T7860	nsubj	Males,exhibited
R2194	T7861	T7862	det	an,increase
R2195	T7742	T7731	punct	", ",displayed
R2196	T7862	T7860	dobj	increase,exhibited
R2197	T7863	T7862	prep	in,increase
R2198	T7864	T7863	pobj	AI,in
R2199	T7865	T7866	punct	(,0.0256
R2200	T7866	T7862	parataxis	0.0256,increase
R2201	T7867	T7866	nsubj	P,0.0256
R2202	T7743	T7731	advcl	similar,displayed
R2203	T7868	T7866	punct	=,0.0256
R2204	T7869	T7866	punct	),0.0256
R2205	T7744	T7743	prep	to,similar
R2206	T7870	T7862	prep	with,increase
R2207	T7871	T7872	det	a,decrease
R2208	T7872	T7870	pobj	decrease,with
R2209	T7745	T7746	compound	B62M,mice
R2210	T7873	T7872	prep	in,decrease
R2211	T7874	T7873	pobj	BMI,in
R2212	T7875	T7876	punct	(,0.0462
R2213	T7746	T7744	pobj	mice,to
R2214	T7876	T7872	parataxis	0.0462,decrease
R2215	T7877	T7876	nsubj	P,0.0462
R2216	T7747	T7748	punct	(,Table
R2217	T7748	T7731	parataxis	Table,displayed
R2218	T7749	T7748	nummod	2,Table
R2219	T7750	T7748	punct	),Table
R2220	T7751	T7731	punct	.,displayed
R2221	T7878	T7876	punct	=,0.0462
R2222	T7879	T7876	punct	),0.0462
R2223	T7753	T7754	det	These,results
R2224	T7880	T7860	cc	and,exhibited
R2225	T7754	T7755	nsubj	results,indicate
R2226	T7881	T7882	det	the,opposite
R2227	T7882	T7884	nsubjpass	opposite,seen
R2228	T7756	T7757	nsubj	QTL,decrease
R2229	T7883	T7882	amod	exact,opposite
R2230	T7884	T7860	conj	seen,exhibited
R2231	T7885	T7884	auxpass	was,seen
R2232	T7886	T7884	prep	in,seen
R2233	T7757	T7755	advcl	decrease,indicate
R2234	T7887	T7886	pobj	females,in
R2235	T7888	T7889	punct	(,0.0425
R2236	T7758	T7756	prep	within,QTL
R2237	T7889	T7884	parataxis	0.0425,seen
R2238	T7890	T7891	dep	AI,0.0001
R2239	T7891	T7889	dep	0.0001,0.0425
R2240	T7759	T7758	pobj	Region,within
R2241	T7892	T7891	punct	", ",0.0001
R2242	T7893	T7891	nsubj	P,0.0001
R2243	T7894	T7891	punct	<,0.0001
R2244	T7895	T7889	punct	;,0.0425
R2245	T7760	T7759	nummod	II,Region
R2246	T7896	T7889	dep	BMI,0.0425
R2247	T7897	T7889	punct	", ",0.0425
R2248	T7761	T7756	acl	shared,QTL
R2249	T7898	T7889	nsubj	P,0.0425
R2250	T7899	T7889	punct	=,0.0425
R2251	T7900	T7889	punct	),0.0425
R2252	T7901	T7902	punct	(,Table
R2253	T7902	T7884	parataxis	Table,seen
R2254	T7903	T7902	nummod	2,Table
R2255	T7762	T7761	prep	between,shared
R2256	T7904	T7902	punct	),Table
R2257	T7905	T7884	punct	.,seen
R2258	T7763	T7764	det	the,strains
R2260	T7764	T7762	pobj	strains,between
R2261	T7909	T7908	punct	", ",impacted
R2262	T7910	T7911	det	the,QTL
R2264	T7765	T7764	nmod	HG2P,strains
R2265	T7912	T7911	compound	obesity,QTL
R2266	T7913	T7911	prep	in,QTL
R2267	T7766	T7765	cc	and,HG2P
R2268	T7914	T7915	det	the,region
R2269	T7915	T7913	pobj	region,in
R2270	T7916	T7915	nmod	HG2M,region
R2271	T7767	T7765	conj	HG2PM,HG2P
R2272	T7917	T7915	amod	unique,region
R2273	T7918	T7915	punct	(,region
R2274	T7919	T7915	appos	Region,region
R2275	T7768	T7769	compound	body,size
R2276	T7920	T7919	nummod	IV,Region
R2277	T7921	T7908	punct	),impacted
R2278	T7922	T7908	auxpass	is,impacted
R2279	T7769	T7757	dobj	size,decrease
R2280	T7923	T7908	advmod	profoundly,impacted
R2281	T7924	T7908	agent	by,impacted
R2282	T7925	T7926	det	the,presence
R2283	T7770	T7769	punct	", ",size
R2284	T7926	T7924	pobj	presence,by
R2285	T7927	T7926	prep	of,presence
R2286	T7771	T7772	compound	weight,gain
R2287	T7928	T7927	pobj	hg,of
R2288	T7929	T7908	punct	.,impacted
R2289	T7983	T7977	cc	and,B6
R2290	T7932	T7931	prep	of,Confirmation
R2291	T7933	T7934	compound	QTL,hg
R2292	T7934	T7936	compound	hg,interactions
R2293	T7935	T7934	punct	-,hg
R2294	T7984	T7977	conj	HG,B6
R2295	T7936	T7932	pobj	interactions,of
R2296	T7985	T7986	punct	(,hg
R2297	T7938	T7939	det	An,feature
R2298	T7939	T7941	nsubj	feature,was
R2299	T7940	T7939	amod	important,feature
R2300	T7986	T7984	parataxis	hg,HG
R2301	T7942	T7939	prep	of,feature
R2302	T7943	T7944	poss	our,design
R2303	T7944	T7942	pobj	design,of
R2304	T7945	T7944	amod	experimental,design
R2305	T7946	T7947	det	the,ability
R2306	T7987	T7986	compound	hg,hg
R2307	T7947	T7941	attr	ability,was
R2308	T7948	T7949	aux	to,test
R2309	T7949	T7947	acl	test,ability
R2310	T7988	T7986	punct	/,hg
R2311	T7950	T7949	prep	for,test
R2312	T7951	T7950	pobj	interactions,for
R2313	T7952	T7951	prep	between,interactions
R2314	T7989	T7986	punct	),hg
R2315	T7953	T7952	pobj	QTL,between
R2316	T7954	T7949	prep	in,test
R2317	T7990	T7941	punct	.,was
R2318	T7955	T7956	det	each,region
R2319	T7956	T7954	pobj	region,in
R2320	T7957	T7958	compound	MMU2,donor
R2321	T7958	T7956	compound	donor,region
R2322	T7992	T7993	amod	Significant,interactions
R2323	T7959	T7949	cc	and,test
R2324	T7960	T7949	conj	genotype,test
R2325	T7961	T7960	prep	at,genotype
R2326	T7962	T7963	det	the,locus
R2327	T7993	T7994	nsubjpass	interactions,viewed
R2328	T7963	T7961	pobj	locus,at
R2329	T7964	T7963	compound	HG,locus
R2330	T7965	T7960	punct	", ",genotype
R2331	T7995	T7993	prep	between,interactions
R2332	T7966	T7967	mark	since,introgressed
R2333	T7996	T7997	compound	donor,region
R2334	T7967	T7960	advcl	introgressed,genotype
R2335	T7968	T7969	amod	identical,regions
R2336	T7997	T7995	pobj	region,between
R2337	T7969	T7967	nsubjpass	regions,introgressed
R2338	T7970	T7969	compound	donor,regions
R2339	T7971	T7967	auxpass	were,introgressed
R2340	T7998	T7997	cc	and,region
R2341	T7972	T7967	prep	on,introgressed
R2342	T7973	T7974	nummod	two,backgrounds
R2343	T7974	T7972	pobj	backgrounds,on
R2345	T7975	T7974	amod	genetic,backgrounds
R2346	T7976	T7974	punct	", ",backgrounds
R2347	T8000	T7997	conj	genotype,region
R2348	T7977	T7974	appos	B6,backgrounds
R2349	T7978	T7979	punct	(,+
R2350	T8001	T7994	auxpass	were,viewed
R2351	T7979	T7977	punct	+,B6
R2352	T7980	T7979	punct	+,+
R2353	T8002	T7994	prep	as,viewed
R2354	T7981	T7979	punct	/,+
R2355	T7982	T7979	punct	),+
R2356	T8003	T8004	amod	strong,evidence
R2357	T8004	T8002	pobj	evidence,as
R2358	T8089	T8086	dobj	set,represents
R2359	T8005	T8006	mark	that,reside
R2360	T8090	T8089	prep	of,set
R2361	T8091	T8092	amod	linked,QTL
R2362	T8092	T8090	pobj	QTL,of
R2363	T8006	T8004	acl	reside,evidence
R2364	T8093	T8092	prep	between,QTL
R2365	T8094	T8095	nummod	74.9,Mbp
R2366	T8095	T8093	pobj	Mbp,between
R2367	T8096	T8094	cc	and,74.9
R2368	T8007	T8008	compound	hg,QTL
R2369	T8097	T8094	conj	181.8,74.9
R2370	T8098	T8089	prep	within,set
R2371	T8008	T8006	nsubj	QTL,reside
R2372	T8099	T8100	det	the,regions
R2373	T8100	T8098	pobj	regions,within
R2374	T8101	T8100	nmod	2M,regions
R2375	T8009	T8008	compound	modifier,QTL
R2376	T8102	T8101	cc	and,2M
R2377	T8103	T8101	conj	2D,2M
R2378	T8104	T8100	compound	donor,regions
R2379	T8010	T8006	prep	within,reside
R2380	T8105	T8100	punct	(,regions
R2381	T8106	T8107	nmod	Region,III
R2382	T8107	T8100	appos	III,regions
R2383	T8011	T8012	det	that,region
R2384	T8108	T8109	punct	–,V
R2385	T8109	T8107	prep	V,III
R2386	T8110	T8100	punct	),regions
R2387	T8012	T8010	pobj	region,within
R2388	T8111	T8100	punct	", ",regions
R2389	T8112	T8113	dep	some,interact
R2390	T8113	T8100	relcl	interact,regions
R2391	T8013	T8012	amod	unique,region
R2392	T8114	T8112	prep	of,some
R2393	T8115	T8114	pobj	which,of
R2394	T8116	T8113	prep	with,interact
R2395	T8014	T8012	amod	genomic,region
R2396	T8117	T8116	pobj	hg,with
R2397	T8118	T8073	punct	.,hypothesized
R2398	T8015	T7994	punct	.,viewed
R2399	T8120	T8121	advcl	Following,expected
R2400	T8122	T8123	det	this,logic
R2401	T8017	T8018	prep	In,were
R2402	T8123	T8120	dobj	logic,Following
R2403	T8124	T8121	nsubj	we,expected
R2404	T8125	T8126	nsubj	one,exhibit
R2405	T8126	T8121	advcl	exhibit,expected
R2406	T8127	T8125	cc	or,one
R2407	T8128	T8125	conj	both,one
R2408	T8129	T8125	prep	of,one
R2409	T8019	T8020	det	the,analysis
R2410	T8130	T8131	det	these,strains
R2411	T8131	T8129	pobj	strains,of
R2412	T8132	T8126	aux	would,exhibit
R2413	T8133	T8134	nmod	donor,region
R2414	T8134	T8135	nmod	region,interactions
R2415	T8020	T8017	pobj	analysis,In
R2416	T8135	T8126	dobj	interactions,exhibit
R2417	T8136	T8134	prep	by,region
R2418	T8137	T8138	compound	HG,genotype
R2419	T8021	T8020	amod	original,analysis
R2420	T8138	T8136	pobj	genotype,by
R2421	T8022	T8020	compound	linkage,analysis
R2422	T8139	T8121	punct	.,expected
R2423	T8023	T8024	det	the,mode
R2424	T8141	T8142	advmod	Unfortunately,were
R2425	T8024	T8018	nsubj	mode,were
R2426	T8143	T8142	punct	", ",were
R2427	T8144	T8142	nsubj	we,were
R2428	T8025	T8024	prep	of,mode
R2429	T8145	T8142	acomp	unable,were
R2430	T8146	T8147	aux	to,characterize
R2431	T8147	T8145	xcomp	characterize,unable
R2432	T8026	T8027	compound	gene,action
R2433	T8148	T8149	compound	HG2D,mice
R2434	T8149	T8147	dobj	mice,characterize
R2435	T8027	T8025	pobj	action,of
R2436	T8150	T8142	punct	.,were
R2437	T8152	T8153	advmod	However,seen
R2438	T8028	T8024	cc	and,mode
R2439	T8154	T8153	punct	", ",seen
R2440	T8155	T8156	mark	as,noted
R2441	T8029	T8030	amod	peak,location
R2442	T8156	T8153	advcl	noted,seen
R2443	T8157	T8156	advmod	above,noted
R2444	T8158	T8153	punct	", ",seen
R2445	T8030	T8024	conj	location,mode
R2446	T8159	T8160	amod	strong,effects
R2447	T8160	T8153	nsubjpass	effects,seen
R2448	T8161	T8162	npadvmod	sex,specific
R2449	T8031	T8030	prep	of,location
R2450	T8162	T8160	amod	specific,effects
R2451	T8163	T8162	punct	-,specific
R2452	T8032	T8031	pobj	Wg2,of
R2453	T8164	T8153	auxpass	were,seen
R2454	T8165	T8153	prep	in,seen
R2455	T8166	T8167	compound	HG2M,mice
R2456	T8033	T8018	acomp	dependent,were
R2457	T8167	T8165	pobj	mice,in
R2458	T8168	T8153	punct	.,seen
R2459	T8170	T8171	amod	Significant,interactions
R2460	T8171	T8183	nsubjpass	interactions,identified
R2461	T8172	T8173	nmod	2M,region
R2462	T8034	T8033	prep	on,dependent
R2463	T8173	T8171	nmod	region,interactions
R2464	T8174	T8173	nmod	donor,region
R2465	T8035	T8036	det	the,presence
R2466	T8175	T8173	prep	by,region
R2467	T8036	T8034	pobj	presence,on
R2468	T8176	T8177	compound	HG,genotype
R2469	T8177	T8175	pobj	genotype,by
R2470	T8037	T8036	prep	of,presence
R2471	T8178	T8173	prep	by,region
R2472	T8179	T8178	pobj	sex,by
R2473	T8180	T8181	nummod	three,way
R2474	T8038	T8037	pobj	hg,of
R2475	T8181	T8171	compound	way,interactions
R2476	T8182	T8181	punct	-,way
R2477	T8039	T8040	punct	[,24
R2478	T8184	T8171	prep	for,interactions
R2479	T8185	T8184	pobj	AI,for
R2480	T8040	T8018	parataxis	24,were
R2481	T8186	T8187	punct	(,Figure
R2482	T8187	T8185	parataxis	Figure,AI
R2483	T8188	T8189	nsubj	P,0.0004
R2484	T8041	T8040	punct	],24
R2485	T8189	T8187	ccomp	0.0004,Figure
R2486	T8190	T8189	punct	=,0.0004
R2487	T8191	T8187	punct	;,Figure
R2488	T8042	T8043	punct	(,Table
R2489	T8192	T8187	nummod	4,Figure
R2490	T8193	T8187	punct	),Figure
R2491	T8194	T8185	cc	and,AI
R2492	T8043	T8018	parataxis	Table,were
R2493	T8044	T8043	nummod	1,Table
R2494	T8045	T8043	punct	),Table
R2495	T8195	T8185	conj	TF,AI
R2496	T8046	T8018	punct	.,were
R2497	T8196	T8183	auxpass	were,identified
R2498	T8197	T8198	punct	(,Table
R2499	T8048	T8049	prep	In,tested
R2500	T8198	T8183	parataxis	Table,identified
R2501	T8199	T8198	nummod	3,Table
R2502	T8200	T8198	punct	),Table
R2503	T8201	T8183	punct	.,identified
R2504	T8050	T8051	det	the,study
R2505	T8203	T8204	det	The,basis
R2506	T8204	T8205	nsubj	basis,was
R2507	T8051	T8048	pobj	study,In
R2508	T8206	T8204	prep	of,basis
R2509	T8207	T8208	det	these,interactions
R2510	T8208	T8206	pobj	interactions,of
R2511	T8209	T8210	det	a,decrease
R2512	T8052	T8051	amod	present,study
R2513	T8210	T8205	attr	decrease,was
R2514	T8211	T8210	prep	in,decrease
R2515	T8212	T8213	compound	HG2M,female
R2516	T8213	T8211	pobj	female,in
R2517	T8053	T8049	punct	", ",tested
R2518	T8214	T8210	cc	and,decrease
R2519	T8215	T8216	det	an,increase
R2520	T8216	T8217	nmod	increase,adiposity
R2521	T8054	T8055	advmod	only,mice
R2522	T8217	T8210	conj	adiposity,decrease
R2523	T8218	T8216	prep	in,increase
R2524	T8219	T8218	pobj	HG2M,in
R2525	T8055	T8058	nsubjpass	mice,characterized
R2526	T8220	T8219	amod	male,HG2M
R2527	T8221	T8210	punct	", ",decrease
R2528	T8222	T8210	prep	with,decrease
R2529	T8056	T8055	amod	homozygous,mice
R2530	T8223	T8224	det	no,differences
R2531	T8224	T8222	pobj	differences,with
R2532	T8225	T8224	prep	in,differences
R2533	T8057	T8055	amod	congenic,mice
R2534	T8226	T8227	compound	fat,accumulation
R2535	T8227	T8225	pobj	accumulation,in
R2536	T8058	T8049	ccomp	characterized,tested
R2537	T8228	T8224	prep	across,differences
R2538	T8059	T8058	auxpass	were,characterized
R2539	T8229	T8230	compound	B62M,sexes
R2540	T8230	T8228	pobj	sexes,across
R2541	T8060	T8049	punct	", ",tested
R2542	T8231	T8205	punct	.,was
R2543	T8233	T8234	amod	Significant,interactions
R2544	T8061	T8049	advmod	thus,tested
R2545	T8234	T8256	nsubjpass	interactions,seen
R2546	T8235	T8236	nmod	2PM,region
R2547	T8236	T8238	nmod	region,way
R2548	T8062	T8049	punct	", ",tested
R2549	T8237	T8236	nmod	donor,region
R2550	T8238	T8234	nmod	way,interactions
R2551	T8239	T8236	prep	by,region
R2552	T8063	T8064	det	the,effects
R2553	T8240	T8241	compound	HG,genotype
R2554	T8241	T8239	pobj	genotype,by
R2555	T8064	T8049	nsubjpass	effects,tested
R2556	T8242	T8238	nummod	two,way
R2557	T8243	T8238	punct	-,way
R2558	T8244	T8238	cc	and,way
R2559	T8065	T8064	amod	overdominant,effects
R2560	T8245	T8246	nmod	2PM,region
R2561	T8246	T8248	nmod	region,way
R2562	T8247	T8246	nmod	donor,region
R2563	T8248	T8238	conj	way,way
R2564	T8249	T8246	prep	by,region
R2565	T8250	T8251	compound	HG,genotype
R2566	T8066	T8064	prep	of,effects
R2567	T8251	T8249	pobj	genotype,by
R2568	T8252	T8246	prep	by,region
R2569	T8253	T8252	pobj	sex,by
R2570	T8067	T8066	pobj	Wg2,of
R2571	T8254	T8248	nummod	three,way
R2572	T8255	T8248	punct	-,way
R2573	T8068	T8049	auxpass	were,tested
R2574	T8257	T8256	auxpass	were,seen
R2575	T8258	T8256	advmod	also,seen
R2576	T8069	T8049	neg	not,tested
R2577	T8259	T8256	prep	for,seen
R2578	T8260	T8259	pobj	TF,for
R2579	T8261	T8260	cc	and,TF
R2580	T8070	T8049	punct	.,tested
R2581	T8262	T8260	conj	AI,TF
R2582	T8263	T8264	punct	(,Table
R2583	T8264	T8256	parataxis	Table,seen
R2584	T8072	T8073	advmod	However,hypothesized
R2585	T8265	T8264	nummod	3,Table
R2586	T8266	T8264	punct	),Table
R2587	T8267	T8256	punct	.,seen
R2588	T8074	T8073	punct	", ",hypothesized
R2589	T8269	T8270	prep	In,observed
R2590	T8271	T8269	pobj	addition,In
R2591	T8272	T8270	punct	", ",observed
R2592	T8075	T8076	mark	since,differed
R2593	T8273	T8274	amod	significant,interactions
R2594	T8274	T8270	nsubjpass	interactions,observed
R2595	T8076	T8073	advcl	differed,hypothesized
R2596	T8275	T8276	nmod	2P,region
R2597	T8276	T8274	nmod	region,interactions
R2598	T8277	T8276	nmod	donor,region
R2599	T8077	T8078	poss	its,location
R2600	T8278	T8279	punct	×,genotype
R2601	T8279	T8276	prep	genotype,region
R2602	T8280	T8279	compound	HG,genotype
R2603	T8078	T8076	nsubj	location,differed
R2604	T8281	T8270	auxpass	were,observed
R2605	T8282	T8270	prep	for,observed
R2606	T8283	T8284	det	all,traits
R2607	T8079	T8078	amod	original,location
R2608	T8284	T8282	pobj	traits,for
R2609	T8285	T8284	acl	listed,traits
R2610	T8286	T8270	punct	", ",observed
R2611	T8080	T8078	compound	peak,location
R2613	T8288	T8270	advcl	reached,observed
R2614	T8289	T8290	det	some,traits
R2615	T8290	T8288	nsubj	traits,reached
R2616	T8291	T8288	aux	did,reached
R2618	T8081	T8076	advcl	dependent,differed
R2619	T8293	T8288	prep	at,reached
R2620	T8294	T8295	det	the,0.0071
R2621	T8295	T8293	pobj	0.0071,at
R2622	T8082	T8081	prep	on,dependent
R2623	T8296	T8295	amod	critical,0.0071
R2624	T8297	T8295	nsubj	P,0.0071
R2625	T8298	T8295	punct	<,0.0071
R2626	T8083	T8082	pobj	background,on
R2627	T8299	T8300	punct	(,Table
R2628	T8300	T8270	parataxis	Table,observed
R2629	T8084	T8073	nsubj	we,hypothesized
R2630	T8085	T8086	mark	that,represents
R2631	T8086	T8073	ccomp	represents,hypothesized
R2632	T8301	T8300	nummod	3,Table
R2633	T8302	T8300	punct	),Table
R2634	T8087	T8086	nsubj	Wg2,represents
R2635	T8303	T8270	punct	.,observed
R2636	T8088	T8089	det	a,set
R2637	T8305	T8306	det	The,basis
R2638	T8306	T8307	nsubj	basis,was
R2639	T8308	T8306	prep	for,basis
R2640	T8309	T8310	det	each,interaction
R2641	T8310	T8308	pobj	interaction,for
R2642	T8311	T8312	det	a,decrease
R2643	T8312	T8307	attr	decrease,was
R2644	T8313	T8312	prep	in,decrease
R2645	T8314	T8313	pobj	phenotype,in
R2646	T8315	T8312	prep	in,decrease
R2647	T8316	T8315	pobj	HG2P,in
R2648	T8317	T8312	prep	compared,decrease
R2649	T8318	T8317	prep	to,compared
R2650	T8319	T8318	pobj	HGC,to
R2651	T8320	T8312	cc	and,decrease
R2652	T8321	T8322	det	no,difference
R2653	T8322	T8312	conj	difference,decrease
R2654	T8323	T8322	prep	between,difference
R2655	T8324	T8323	pobj	B62P,between
R2656	T8325	T8324	cc	and,B62P
R2657	T8326	T8324	conj	B6C,B62P
R2658	T8327	T8307	punct	.,was
R2659	T8329	T8330	advmod	Together,confirm
R2660	T8331	T8332	det	these,data
R2661	T8332	T8330	nsubj	data,confirm
R2662	T8333	T8334	mark	that,modify
R2663	T8334	T8330	ccomp	modify,confirm
R2664	T8335	T8336	compound	MMU2,QTL
R2665	T8336	T8334	nsubj	QTL,modify
R2666	T8337	T8338	det	the,effects
R2667	T8338	T8334	dobj	effects,modify
R2668	T8339	T8338	prep	of,effects
R2669	T8340	T8341	det	the,deletion
R2670	T8341	T8339	pobj	deletion,of
R2671	T8342	T8341	compound	hg,deletion
R2672	T8343	T8330	punct	.,confirm
R2673	T11091	T11092	npadvmod	Speed,congenic
R2674	T11092	T11093	amod	congenic,strains
R2675	T11094	T11093	prep	for,strains
R2676	T11095	T11094	pobj	QTL,for
R2677	T11096	T11093	prep	on,strains
R2678	T11097	T11098	nmod	MMU,1
R2679	T11098	T11096	pobj	1,on
R2680	T11099	T11098	punct	", ",1
R2681	T11100	T11098	conj	8,1
R2682	T11101	T11100	punct	", ",8
R2683	T11102	T11100	conj	9,8
R2684	T11103	T11102	punct	", ",9
R2685	T11104	T11102	conj	11,9
R2686	T11105	T11104	cc	and,11
R2687	T11106	T11104	conj	17,11
R2688	T11110	T11111	nsubj	Q1Ucd1,was
R2689	T11112	T11110	acl	affecting,Q1Ucd1
R2690	T11113	T11112	dobj	G26,affecting
R2691	T11114	T11115	det	the,significant
R2692	T11115	T11111	attr	significant,was
R2693	T11116	T11115	amod	least,significant
R2694	T11117	T11115	prep	of,significant
R2695	T11118	T11119	det	any,QTL
R2696	T11119	T11117	pobj	QTL,of
R2697	T11120	T11119	acl	identified,QTL
R2698	T11121	T11120	prep	in,identified
R2699	T11122	T11123	det	the,intercross
R2700	T11123	T11121	pobj	intercross,in
R2701	T11124	T11123	amod	original,intercross
R2702	T11125	T11111	cc	and,was
R2703	T11126	T11127	advmod	only,reached
R2704	T11127	T11111	conj	reached,was
R2705	T11128	T11129	det	a,level
R2706	T11129	T11127	dobj	level,reached
R2707	T11130	T11129	amod	suggestive,level
R2708	T11131	T11129	prep	of,level
R2709	T11132	T11131	pobj	significance,of
R2710	T11133	T11134	punct	(,0.05
R2711	T11134	T11127	parataxis	0.05,reached
R2712	T11135	T11136	nsubj	LOD,2.46
R2713	T11136	T11134	ccomp	2.46,0.05
R2714	T11137	T11136	punct	=,2.46
R2715	T11138	T11134	punct	", ",0.05
R2716	T11139	T11134	nsubj	P,0.05
R2717	T11140	T11134	punct	<,0.05
R2718	T11141	T11134	punct	),0.05
R2719	T11142	T11143	punct	[,26
R2720	T11143	T11127	parataxis	26,reached
R2721	T11144	T11143	punct	],26
R2722	T11145	T11111	punct	.,was
R2723	T11147	T11148	prep	In,had
R2724	T11149	T11147	pobj	accordance,In
R2725	T11150	T11148	punct	", ",had
R2726	T11151	T11152	compound	HG1,mice
R2727	T11152	T11148	nsubj	mice,had
R2728	T11153	T11154	amod	small,differences
R2729	T11154	T11148	dobj	differences,had
R2730	T11155	T11154	prep	in,differences
R2731	T11156	T11157	det	all,traits
R2732	T11157	T11155	pobj	traits,in
R2733	T11158	T11157	nmod	growth,traits
R2734	T11159	T11158	cc	and,growth
R2735	T11160	T11158	conj	length,growth
R2736	T11161	T11148	punct	.,had
R2737	T11163	T11164	nsubj	NA,was
R2738	T11165	T11163	prep	in,NA
R2739	T11166	T11167	preconj	both,sexes
R2740	T11167	T11165	pobj	sexes,in
R2741	T11168	T11163	cc	and,NA
R2742	T11169	T11170	nmod	2WK,6WK
R2743	T11170	T11163	conj	6WK,NA
R2744	T11171	T11170	punct	", ",6WK
R2745	T11172	T11170	nmod	3WK,6WK
R2746	T11173	T11170	punct	", ",6WK
R2747	T11174	T11170	cc	and,6WK
R2748	T11175	T11176	compound	tail,length
R2749	T11176	T11170	conj	length,6WK
R2750	T11177	T11170	prep	in,6WK
R2751	T11178	T11177	pobj	females,in
R2752	T11179	T11164	acomp	significant,was
R2753	T11180	T11164	prep	at,was
R2754	T11181	T11182	det	a,0.005
R2755	T11182	T11180	pobj	0.005,at
R2756	T11183	T11182	amod	critical,0.005
R2757	T11184	T11182	nsubj	P,0.005
R2758	T11185	T11182	punct	<,0.005
R2759	T11186	T11187	punct	(,Table
R2760	T11187	T11164	parataxis	Table,was
R2761	T11188	T11187	nummod	4,Table
R2762	T11189	T11187	punct	),Table
R2763	T11190	T11164	punct	.,was
R2764	T11192	T11193	det	The,difference
R2765	T11193	T11195	nsubj	difference,was
R2766	T11194	T11193	amod	only,difference
R2767	T11196	T11193	prep	in,difference
R2768	T11197	T11196	pobj	adiposity,in
R2769	T11198	T11199	det	a,decrease
R2770	T11199	T11195	attr	decrease,was
R2771	T11200	T11199	amod	significant,decrease
R2772	T11201	T11199	prep	in,decrease
R2773	T11202	T11203	amod	male,MFP
R2774	T11203	T11201	pobj	MFP,in
R2775	T11204	T11205	punct	(,Table
R2776	T11205	T11195	parataxis	Table,was
R2777	T11206	T11205	nummod	5,Table
R2778	T11207	T11205	punct	),Table
R2779	T11208	T11195	punct	.,was
R2780	T11210	T11211	det	The,capture
R2781	T11211	T11213	nsubj	capture,adds
R2782	T11212	T11211	amod	successful,capture
R2783	T11214	T11211	cc	and,capture
R2784	T11215	T11211	conj	confirmation,capture
R2785	T11216	T11211	prep	of,capture
R2786	T11217	T11218	det	the,QTL
R2787	T11218	T11216	pobj	QTL,of
R2788	T11219	T11220	amod	small,effect
R2789	T11220	T11218	compound	effect,QTL
R2790	T11221	T11222	compound	Q1Ucd1,w26
R2791	T11222	T11218	compound	w26,QTL
R2792	T11223	T11222	punct	-,w26
R2793	T11224	T11213	dobj	support,adds
R2794	T11225	T11213	prep	to,adds
R2795	T11226	T11225	pcomp	pursuing,to
R2796	T11227	T11226	dobj	QTL,pursuing
R2797	T11228	T11227	acl	identified,QTL
R2798	T11229	T11228	prep	at,identified
R2799	T11230	T11231	amod	suggestive,levels
R2800	T11231	T11229	pobj	levels,at
R2801	T11232	T11231	prep	of,levels
R2802	T11233	T11234	amod	statistical,confidence
R2803	T11234	T11232	pobj	confidence,of
R2804	T11235	T11228	prep	from,identified
R2805	T11236	T11237	compound	genome,scans
R2806	T11237	T11235	pobj	scans,from
R2807	T11238	T11213	punct	.,adds
R2808	T11242	T11243	nsubjpass	Markers,linked
R2809	T11244	T11242	prep	on,Markers
R2810	T11245	T11244	pobj	MMU8,on
R2811	T11246	T11243	auxpass	were,linked
R2812	T11247	T11243	prep	with,linked
R2813	T11248	T11247	pobj	G29,with
R2814	T11249	T11243	prep	in,linked
R2815	T11250	T11251	det	the,intercross
R2816	T11251	T11249	pobj	intercross,in
R2817	T11252	T11251	amod	original,intercross
R2818	T11253	T11254	punct	[,24
R2819	T11254	T11243	parataxis	24,linked
R2820	T11255	T11254	punct	],24
R2821	T11256	T11243	punct	.,linked
R2822	T11258	T11259	det	This,QTL
R2823	T11259	T11260	nsubj	QTL,was
R2824	T11261	T11260	acomp	small,was
R2825	T11262	T11260	punct	", ",was
R2826	T11263	T11264	advmod	only,accounting
R2827	T11264	T11260	advcl	accounting,was
R2828	T11265	T11264	prep	for,accounting
R2829	T11266	T11267	nummod	4.3,%
R2830	T11267	T11265	pobj	%,for
R2831	T11268	T11267	prep	of,%
R2832	T11269	T11270	det	the,variance
R2833	T11270	T11268	pobj	variance,of
R2834	T11271	T11270	amod	phenotypic,variance
R2835	T11272	T11260	punct	.,was
R2836	T11274	T11275	advmod	Interestingly,detected
R2837	T11275	T11285	ccomp	detected,were
R2838	T11276	T11275	punct	", ",detected
R2839	T11277	T11275	prep	in,detected
R2840	T11278	T11279	compound	HG8,mice
R2841	T11279	T11277	pobj	mice,in
R2842	T11280	T11281	det	no,differences
R2843	T11281	T11275	nsubjpass	differences,detected
R2844	T11282	T11281	prep	in,differences
R2845	T11283	T11282	pobj	growth,in
R2846	T11284	T11275	auxpass	were,detected
R2847	T11286	T11285	punct	;,were
R2848	T11287	T11285	advmod	however,were
R2849	T11288	T11285	punct	", ",were
R2850	T11289	T11285	nsubj	they,were
R2851	T11290	T11291	advmod	significantly,leaner
R2852	T11291	T11285	acomp	leaner,were
R2853	T11292	T11291	prep	than,leaner
R2854	T11293	T11292	pobj	controls,than
R2855	T11294	T11295	punct	(,Table
R2856	T11295	T11285	parataxis	Table,were
R2857	T11296	T11295	nummod	5,Table
R2858	T11297	T11295	punct	),Table
R2859	T11298	T11285	punct	.,were
R2860	T11300	T11301	prep	In,was
R2861	T11302	T11300	pobj	males,In
R2862	T11303	T11304	det	a,decrease
R2863	T11304	T11306	nsubjpass	decrease,detected
R2864	T11305	T11304	amod	general,decrease
R2865	T11306	T11301	ccomp	detected,was
R2866	T11307	T11304	prep	in,decrease
R2867	T11308	T11309	compound	fat,pad
R2868	T11309	T11310	compound	pad,mass
R2869	T11310	T11307	pobj	mass,in
R2870	T11311	T11310	punct	", ",mass
R2871	T11312	T11310	conj	TF,mass
R2872	T11313	T11312	cc	and,TF
R2873	T11314	T11312	conj	AI,TF
R2874	T11315	T11306	auxpass	was,detected
R2875	T11316	T11301	punct	;,was
R2876	T11317	T11301	advmod	however,was
R2877	T11318	T11301	punct	", ",was
R2878	T11319	T11320	advmod	only,MFP
R2879	T11320	T11301	nsubj	MFP,was
R2880	T11321	T11301	acomp	significant,was
R2881	T11322	T11301	prep	at,was
R2882	T11323	T11324	det	a,0.005
R2883	T11324	T11322	pobj	0.005,at
R2884	T11325	T11324	amod	critical,0.005
R2885	T11326	T11324	nsubj	P,0.005
R2886	T11327	T11324	punct	<,0.005
R2887	T11328	T11301	punct	.,was
R2888	T11330	T11331	amod	Male,AI
R2889	T11331	T11332	nsubj	AI,was
R2890	T11333	T11334	advmod	nearly,significant
R2891	T11334	T11332	acomp	significant,was
R2892	T11335	T11332	prep	at,was
R2893	T11336	T11337	det	a,0.0082
R2894	T11337	T11335	pobj	0.0082,at
R2895	T11338	T11337	amod	nominal,0.0082
R2896	T11339	T11337	nsubj	P,0.0082
R2897	T11340	T11337	punct	=,0.0082
R2898	T11341	T11332	punct	.,was
R2899	T11343	T11344	amod	Larger,decreases
R2900	T11344	T11345	nsubjpass	decreases,seen
R2901	T11346	T11344	prep	in,decreases
R2902	T11347	T11348	compound	fat,mass
R2903	T11348	T11346	pobj	mass,in
R2904	T11349	T11345	auxpass	were,seen
R2905	T11350	T11345	prep	in,seen
R2906	T11351	T11352	compound	HG8,females
R2907	T11352	T11350	pobj	females,in
R2908	T11353	T11345	punct	", ",seen
R2909	T11354	T11355	mark	with,detected
R2910	T11355	T11345	advcl	detected,seen
R2911	T11356	T11357	amod	significant,decreases
R2912	T11357	T11355	nsubj	decreases,detected
R2913	T11358	T11355	prep	for,detected
R2914	T11359	T11358	pobj	GFP,for
R2915	T11360	T11359	punct	", ",GFP
R2916	T11361	T11359	conj	MFP,GFP
R2917	T11362	T11361	cc	and,MFP
R2918	T11363	T11361	conj	AI,MFP
R2919	T11364	T11345	punct	.,seen
R2920	T11366	T11367	advmod	Additionally,were
R2921	T11368	T11367	punct	", ",were
R2922	T11369	T11367	nsubj	RFP,were
R2923	T11370	T11369	cc	and,RFP
R2924	T11371	T11369	conj	TF,RFP
R2925	T11372	T11373	advmod	nearly,significant
R2926	T11373	T11367	acomp	significant,were
R2927	T11374	T11367	prep	with,were
R2928	T11375	T11376	amod	nominal,values
R2929	T11376	T11374	pobj	values,with
R2930	T11377	T11376	compound	P,values
R2931	T11378	T11376	prep	of,values
R2932	T11379	T11378	pobj	0.0208,of
R2933	T11380	T11379	cc	and,0.0208
R2934	T11381	T11379	conj	0.0153,0.0208
R2935	T11382	T11367	punct	", ",were
R2936	T11383	T11367	advmod	respectively,were
R2937	T11384	T11367	punct	.,were
R2938	T11386	T11387	compound	HG8,mice
R2939	T11387	T11388	nsubj	mice,represent
R2940	T11389	T11390	det	a,model
R2941	T11390	T11388	dobj	model,represent
R2942	T11391	T11390	amod	lean,model
R2943	T11392	T11390	amod	congenic,model
R2944	T11393	T11394	prep	in,protect
R2945	T11394	T11390	relcl	protect,model
R2946	T11395	T11393	pobj	which,in
R2947	T11396	T11397	compound	CAST,alleles
R2948	T11397	T11394	nsubj	alleles,protect
R2949	T11398	T11394	prep	against,protect
R2950	T11399	T11400	compound	fat,accumulation
R2951	T11400	T11398	pobj	accumulation,against
R2952	T11401	T11388	punct	.,represent
R2953	T11405	T11406	compound	CAST,alleles
R2954	T11406	T11407	nsubjpass	alleles,found
R2955	T11408	T11406	prep	in,alleles
R2956	T11409	T11410	det	the,region
R2957	T11410	T11408	pobj	region,in
R2958	T11411	T11410	amod	proximal,region
R2959	T11412	T11410	prep	of,region
R2960	T11413	T11412	pobj	MMU9,of
R2961	T11414	T11407	auxpass	were,found
R2962	T11415	T11407	advmod	previously,found
R2963	T11416	T11417	aux	to,linked
R2964	T11417	T11407	xcomp	linked,found
R2965	T11418	T11417	auxpass	be,linked
R2966	T11419	T11417	prep	with,linked
R2967	T11420	T11421	det	an,increase
R2968	T11421	T11419	pobj	increase,with
R2969	T11422	T11421	prep	in,increase
R2970	T11423	T11424	compound	body,fat
R2971	T11424	T11425	compound	fat,percentage
R2972	T11425	T11422	pobj	percentage,in
R2973	T11426	T11421	cc	and,increase
R2974	T11427	T11428	det	a,decrease
R2975	T11428	T11421	conj	decrease,increase
R2976	T11429	T11428	prep	in,decrease
R2977	T11430	T11431	compound	femur,length
R2978	T11431	T11429	pobj	length,in
R2979	T11432	T11433	punct	[,24
R2980	T11433	T11407	parataxis	24,found
R2981	T11434	T11433	punct	],24
R2982	T11435	T11407	punct	.,found
R2983	T11437	T11438	det	The,effects
R2984	T11438	T11439	nsubj	effects,appeared
R2985	T11440	T11441	aux	to,be
R2986	T11441	T11439	xcomp	be,appeared
R2987	T11442	T11443	det	the,result
R2988	T11443	T11441	attr	result,be
R2989	T11444	T11443	prep	of,result
R2990	T11445	T11446	nummod	two,QTL
R2991	T11446	T11444	pobj	QTL,of
R2992	T11447	T11446	amod	linked,QTL
R2993	T11448	T11446	punct	", ",QTL
R2994	T11449	T11446	appos	Carfhg2,QTL
R2995	T11450	T11449	prep	at,Carfhg2
R2996	T11451	T11452	nummod	10,cM
R2997	T11452	T11450	pobj	cM,at
R2998	T11453	T11449	cc	and,Carfhg2
R2999	T11454	T11449	conj	Feml2,Carfhg2
R3000	T11455	T11454	prep	at,Feml2
R3001	T11456	T11457	nummod	20,cM
R3002	T11457	T11455	pobj	cM,at
R3003	T11535	T11533	punct	", ",increased
R3004	T11458	T11446	punct	", ",QTL
R3005	T11536	T11533	nsubjpass	GFP,increased
R3006	T11537	T11536	punct	", ",GFP
R3007	T11459	T11446	prep	instead,QTL
R3008	T11538	T11536	conj	RFP,GFP
R3009	T11539	T11538	punct	", ",RFP
R3010	T11460	T11459	pcomp	of,instead
R3011	T11540	T11538	conj	FFP,RFP
R3012	T11461	T11459	pobj	one,instead
R3013	T11541	T11540	cc	and,FFP
R3014	T11542	T11540	conj	AI,FFP
R3015	T11462	T11463	advmod	pleiotropically,impacting
R3016	T11543	T11533	auxpass	were,increased
R3017	T11544	T11533	prep	by,increased
R3018	T11545	T11546	nummod	29.0,%
R3019	T11463	T11461	acl	impacting,one
R3020	T11546	T11544	pobj	%,by
R3021	T11547	T11546	punct	", ",%
R3022	T11464	T11465	det	both,traits
R3023	T11548	T11549	nummod	51.2,%
R3024	T11549	T11546	conj	%,%
R3025	T11465	T11463	dobj	traits,impacting
R3026	T11550	T11549	punct	", ",%
R3027	T11551	T11552	nummod	42.9,%
R3028	T11552	T11549	conj	%,%
R3029	T11466	T11467	punct	(,Table
R3030	T11553	T11552	cc	and,%
R3031	T11554	T11555	nummod	30.0,%
R3032	T11467	T11439	parataxis	Table,appeared
R3033	T11555	T11552	conj	%,%
R3034	T11556	T11533	punct	", ",increased
R3035	T11557	T11533	advmod	respectively,increased
R3036	T11558	T11533	punct	.,increased
R3037	T11560	T11561	prep	In,were
R3038	T11562	T11560	pobj	females,In
R3039	T11563	T11564	det	these,increases
R3040	T11468	T11467	nummod	1,Table
R3041	T11564	T11561	nsubj	increases,were
R3042	T11565	T11566	advmod	much,larger
R3043	T11566	T11561	acomp	larger,were
R3044	T11469	T11467	punct	),Table
R3045	T11567	T11561	punct	.,were
R3046	T11569	T11570	det	The,measurements
R3047	T11570	T11572	nsubjpass	measurements,increased
R3048	T11571	T11570	amod	same,measurements
R3049	T11573	T11572	auxpass	were,increased
R3050	T11470	T11439	punct	.,appeared
R3051	T11574	T11572	prep	by,increased
R3052	T11575	T11576	nummod	68.8,%
R3053	T11576	T11574	pobj	%,by
R3054	T11577	T11576	punct	", ",%
R3055	T11578	T11579	nummod	99.4,%
R3056	T11472	T11473	prep	In,was
R3057	T11579	T11576	conj	%,%
R3058	T11580	T11579	punct	", ",%
R3059	T11581	T11582	nummod	69.7,%
R3060	T11582	T11579	conj	%,%
R3061	T11583	T11582	cc	and,%
R3062	T11473	T11482	ccomp	was,were
R3063	T11584	T11585	nummod	57.3,%
R3064	T11585	T11582	conj	%,%
R3065	T11474	T11472	pobj	support,In
R3066	T11586	T11572	punct	", ",increased
R3067	T11587	T11572	advcl	relative,increased
R3068	T11588	T11587	prep	to,relative
R3069	T11475	T11474	prep	of,support
R3070	T11589	T11590	compound	HGC,females
R3071	T11590	T11588	pobj	females,to
R3072	T11476	T11475	pobj	this,of
R3073	T11591	T11572	punct	.,increased
R3074	T11477	T11473	punct	", ",was
R3075	T11593	T11594	det	A,reduction
R3076	T11594	T11600	nsubjpass	reduction,detected
R3077	T11595	T11596	nummod	2.9,%
R3078	T11596	T11594	nmod	%,reduction
R3079	T11597	T11596	cc	and,%
R3080	T11598	T11599	nummod	3.6,%
R3081	T11478	T11479	det	the,increase
R3082	T11599	T11596	conj	%,%
R3083	T11601	T11594	prep	in,reduction
R3084	T11602	T11603	amod	male,NA
R3085	T11479	T11473	nsubj	increase,was
R3086	T11603	T11601	pobj	NA,in
R3087	T11604	T11602	cc	and,male
R3088	T11605	T11602	conj	female,male
R3089	T11606	T11600	punct	", ",detected
R3090	T11607	T11600	advmod	respectively,detected
R3091	T11608	T11600	punct	", ",detected
R3092	T11609	T11600	auxpass	was,detected
R3093	T11480	T11479	prep	in,increase
R3094	T11610	T11600	advmod	also,detected
R3095	T11611	T11600	punct	.,detected
R3096	T11481	T11480	pobj	fat,in
R3097	T11613	T11614	nsubjpass	This,expected
R3098	T11483	T11473	acomp	dependent,was
R3099	T11615	T11614	auxpass	was,expected
R3100	T11616	T11617	mark	since,found
R3101	T11484	T11483	prep	on,dependent
R3102	T11485	T11484	pobj	hg,on
R3103	T11617	T11614	advcl	found,expected
R3104	T11618	T11617	nsubjpass	NA,found
R3105	T11486	T11482	punct	;,were
R3106	T11619	T11617	auxpass	was,found
R3107	T11620	T11617	advmod	previously,found
R3108	T11487	T11482	advmod	however,were
R3109	T11621	T11622	aux	to,be
R3110	T11622	T11617	xcomp	be,found
R3111	T11623	T11624	det	an,indicator
R3112	T11488	T11482	punct	", ",were
R3113	T11624	T11622	attr	indicator,be
R3114	T11625	T11624	amod	excellent,indicator
R3115	T11489	T11482	nsubj	differences,were
R3116	T11626	T11624	prep	of,indicator
R3117	T11627	T11628	compound	femur,length
R3118	T11628	T11626	pobj	length,of
R3119	T11490	T11489	prep	in,differences
R3120	T11629	T11630	punct	(,0.88
R3121	T11491	T11492	compound	femur,length
R3122	T11630	T11622	parataxis	0.88,be
R3123	T11631	T11630	nsubj	R2,0.88
R3124	T11632	T11630	punct	=,0.88
R3125	T11492	T11490	pobj	length,in
R3126	T11633	T11630	punct	),0.88
R3127	T11634	T11622	prep	in,be
R3128	T11493	T11482	neg	not,were
R3129	T11635	T11636	compound	HG,mice
R3130	T11636	T11634	pobj	mice,in
R3131	T11494	T11495	punct	[,24
R3132	T11637	T11638	punct	[,27
R3133	T11638	T11617	parataxis	27,found
R3134	T11639	T11638	punct	],27
R3135	T11495	T11482	parataxis	24,were
R3136	T11640	T11617	cc	and,found
R3137	T11496	T11495	punct	],24
R3138	T11497	T11482	punct	.,were
R3139	T11641	T11642	mark	as,noted
R3140	T11642	T11643	advcl	noted,contains
R3141	T11643	T11617	conj	contains,found
R3142	T11644	T11642	advmod	above,noted
R3143	T11499	T11500	prep	In,increased
R3144	T11645	T11646	det	this,region
R3145	T11646	T11643	nsubj	region,contains
R3146	T11647	T11648	det	the,QTL
R3147	T11648	T11643	dobj	QTL,contains
R3148	T11501	T11499	pobj	confirmation,In
R3149	T11649	T11648	compound	Feml2,QTL
R3150	T11650	T11651	punct	[,24
R3151	T11502	T11501	prep	of,confirmation
R3152	T11651	T11643	parataxis	24,contains
R3153	T11652	T11651	punct	],24
R3154	T11653	T11614	punct	.,expected
R3155	T11503	T11502	pobj	Carfhg2,of
R3156	T11504	T11505	det	all,measures
R3157	T11655	T11656	det	These,data
R3158	T11656	T11657	nsubj	data,confirm
R3159	T11505	T11500	nsubjpass	measures,increased
R3160	T11658	T11659	det	the,effects
R3161	T11659	T11657	dobj	effects,confirm
R3162	T11660	T11659	prep	of,effects
R3163	T11506	T11505	prep	of,measures
R3164	T11661	T11660	pobj	Carfhg2,of
R3165	T11662	T11659	prep	on,effects
R3166	T11507	T11506	pobj	adiposity,of
R3167	T11663	T11662	pobj	adiposity,on
R3168	T11664	T11659	cc	and,effects
R3169	T11665	T11659	conj	Feml2,effects
R3170	T11508	T11507	prep	in,adiposity
R3171	T11666	T11665	prep	on,Feml2
R3172	T11667	T11666	pobj	length,on
R3173	T11509	T11510	compound	HG9,mice
R3174	T11668	T11657	cc	and,confirm
R3175	T11669	T11657	conj	indicate,confirm
R3176	T11670	T11671	det	the,effects
R3177	T11510	T11508	pobj	mice,in
R3178	T11671	T11673	nsubj	effects,are
R3179	T11672	T11671	amod	isolated,effects
R3180	T11673	T11669	advcl	are,indicate
R3181	T11511	T11500	auxpass	were,increased
R3182	T11674	T11671	prep	of,effects
R3183	T11675	T11674	pobj	Carfhg2,of
R3184	T11512	T11500	advcl	relative,increased
R3185	T11676	T11677	advmod	more,significant
R3186	T11677	T11673	acomp	significant,are
R3187	T11678	T11679	mark	than,observed
R3188	T11513	T11512	prep	to,relative
R3189	T11679	T11677	advcl	observed,significant
R3190	T11680	T11679	advmod	originally,observed
R3191	T11681	T11657	punct	.,confirm
R3192	T11514	T11515	compound	control,mice
R3193	T11685	T11686	prep	In,linked
R3194	T11687	T11688	det	the,intercross
R3195	T11515	T11513	pobj	mice,to
R3196	T11688	T11685	pobj	intercross,In
R3197	T11689	T11688	amod	original,intercross
R3198	T11516	T11500	punct	;,increased
R3199	T11690	T11691	compound	CAST,alleles
R3200	T11691	T11686	nsubjpass	alleles,linked
R3201	T11692	T11691	prep	near,alleles
R3202	T11517	T11500	prep	except,increased
R3203	T11693	T11694	nummod	50,cM
R3204	T11694	T11692	pobj	cM,near
R3205	T11518	T11517	pobj	MFP,except
R3206	T11695	T11691	prep	on,alleles
R3207	T11696	T11695	pobj	MMU11,on
R3208	T11519	T11518	prep	in,MFP
R3209	T11697	T11686	auxpass	were,linked
R3210	T11698	T11686	prep	with,linked
R3211	T11699	T11700	det	a,reduction
R3212	T11520	T11521	preconj	both,sexes
R3213	T11700	T11698	pobj	reduction,with
R3214	T11701	T11700	prep	in,reduction
R3215	T11702	T11701	pobj	G29,in
R3216	T11521	T11519	pobj	sexes,in
R3217	T11703	T11702	punct	", ",G29
R3218	T11704	T11705	compound	carcass,ash
R3219	T11522	T11518	cc	and,MFP
R3220	T11705	T11702	conj	ash,G29
R3221	T11706	T11705	punct	(,ash
R3222	T11523	T11518	conj	BMI,MFP
R3223	T11707	T11705	appos	ASH,ash
R3224	T11524	T11523	prep	in,BMI
R3228	T11525	T11524	pobj	males,in
R3229	T11711	T11705	conj	protein,ash
R3230	T11712	T11711	punct	(,protein
R3231	T11526	T11527	punct	(,Table
R3232	T11713	T11711	appos	PROT,protein
R3233	T11714	T11686	punct	),linked
R3234	T11715	T11716	punct	[,24
R3235	T11527	T11500	parataxis	Table,increased
R3236	T11716	T11686	parataxis	24,linked
R3237	T11717	T11716	punct	],24
R3238	T11528	T11527	nummod	5,Table
R3239	T11718	T11686	punct	.,linked
R3240	T11529	T11527	punct	),Table
R3241	T11720	T11721	advmod	Therefore,measured
R3242	T11722	T11721	punct	", ",measured
R3243	T11723	T11721	nsubj	we,measured
R3244	T11724	T11725	det	each,component
R3245	T11725	T11721	dobj	component,measured
R3246	T11726	T11725	compound	carcass,component
R3247	T11530	T11500	punct	.,increased
R3248	T11727	T11721	advcl	using,measured
R3249	T11728	T11729	amod	chemical,analysis
R3250	T11729	T11727	dobj	analysis,using
R3251	T11532	T11533	prep	In,increased
R3252	T11730	T11729	amod	compositional,analysis
R3253	T11731	T11727	prep	in,using
R3254	T11732	T11733	det	the,strains
R3255	T11733	T11731	pobj	strains,in
R3256	T11534	T11532	pobj	males,In
R3257	T11734	T11733	nmod	HGC,strains
R3258	T11735	T11734	punct	", ",HGC
R3259	T11736	T11734	conj	HG11,HGC
R3260	T11737	T11736	cc	and,HG11
R3261	T11747	T11748	det	the,presence
R3262	T11738	T11736	conj	HG17,HG11
R3263	T11739	T11721	punct	.,measured
R3264	T11748	T11746	pobj	presence,on
R3265	T11741	T11742	advmod	Originally,was
R3266	T11749	T11748	prep	of,presence
R3267	T11743	T11742	punct	", ",was
R3268	T11744	T11742	nsubj	Carp2,was
R3269	T11745	T11742	acomp	dependent,was
R3270	T11750	T11749	pobj	hg,of
R3271	T11746	T11745	prep	on,dependent
R3272	T11751	T11742	cc	and,was
R3273	T11752	T11753	det	no,effects
R3274	T11753	T11756	nsubjpass	effects,detected
R3275	T11754	T11753	amod	significant,effects
R3276	T11853	T11847	conj	increase,increase
R3277	T11755	T11753	compound	sex,effects
R3278	T11854	T11853	amod	small,increase
R3279	T11855	T11853	amod	suggestive,increase
R3280	T11856	T11853	prep	in,increase
R3281	T11756	T11742	conj	detected,was
R3282	T11857	T11856	pobj	NA,in
R3283	T11858	T11859	punct	(,0.06
R3284	T11757	T11756	auxpass	were,detected
R3285	T11859	T11840	parataxis	0.06,displayed
R3286	T11860	T11859	nsubj	P,0.06
R3287	T11861	T11859	punct	=,0.06
R3288	T11758	T11759	punct	[,24
R3289	T11862	T11859	punct	),0.06
R3290	T11863	T11840	punct	", ",displayed
R3291	T11864	T11865	mark	while,displayed
R3292	T11759	T11742	parataxis	24,was
R3293	T11865	T11840	advcl	displayed,displayed
R3294	T11866	T11865	nsubj	females,displayed
R3295	T11867	T11868	amod	significant,decreases
R3296	T11868	T11865	dobj	decreases,displayed
R3297	T11869	T11868	prep	in,decreases
R3298	T11870	T11869	pobj	NA,in
R3299	T11871	T11840	punct	.,displayed
R3300	T11760	T11759	punct	],24
R3301	T11873	T11874	prep	In,seen
R3302	T11761	T11742	punct	.,was
R3303	T11875	T11873	pobj	support,In
R3304	T11876	T11875	prep	of,support
R3305	T11877	T11878	det	the,QTL
R3306	T11763	T11764	prep	In,displayed
R3307	T11878	T11876	pobj	QTL,of
R3308	T11879	T11880	npadvmod	sex,specific
R3309	T11765	T11763	pobj	contrast,In
R3310	T11880	T11878	amod	specific,QTL
R3311	T11881	T11880	punct	-,specific
R3312	T11882	T11883	nmod	effects,strain
R3313	T11883	T11884	nmod	strain,interactions
R3314	T11766	T11765	prep	to,contrast
R3315	T11884	T11874	nsubjpass	interactions,seen
R3316	T11885	T11883	prep	by,strain
R3317	T11886	T11885	pobj	sex,by
R3318	T11767	T11768	det	those,results
R3319	T11887	T11888	punct	(,0.04
R3320	T11888	T11884	parataxis	0.04,interactions
R3321	T11768	T11766	pobj	results,to
R3322	T11889	T11888	nsubj	P,0.04
R3323	T11890	T11888	punct	<,0.04
R3324	T11891	T11888	punct	),0.04
R3325	T11769	T11764	punct	", ",displayed
R3326	T11892	T11874	auxpass	were,seen
R3327	T11893	T11874	prep	for,seen
R3328	T11894	T11895	det	the,traits
R3329	T11770	T11771	compound	HG11,mice
R3330	T11895	T11893	pobj	traits,for
R3331	T11896	T11895	amod	following,traits
R3332	T11897	T11895	compound	growth,traits
R3333	T11771	T11764	nsubj	mice,displayed
R3334	T11898	T11895	punct	: ,traits
R3335	T11899	T11895	appos	3WK,traits
R3336	T11900	T11899	punct	", ",3WK
R3337	T11772	T11773	amod	significant,differences
R3338	T11901	T11899	conj	6WK,3WK
R3339	T11902	T11901	punct	", ",6WK
R3340	T11903	T11901	conj	9WK,6WK
R3341	T11773	T11764	dobj	differences,displayed
R3342	T11904	T11903	punct	", ",9WK
R3343	T11905	T11903	conj	G26,9WK
R3344	T11906	T11905	punct	", ",G26
R3345	T11774	T11773	prep	in,differences
R3346	T11907	T11905	conj	G29,G26
R3347	T11908	T11907	cc	and,G29
R3348	T11909	T11907	conj	NA,G29
R3349	T11910	T11911	punct	(,shown
R3350	T11911	T11874	parataxis	shown,seen
R3351	T11912	T11911	nsubj	data,shown
R3352	T11913	T11911	neg	not,shown
R3353	T11775	T11774	pobj	growth,in
R3354	T11914	T11911	punct	),shown
R3355	T11915	T11874	punct	.,seen
R3356	T11776	T11775	cc	and,growth
R3357	T11917	T11918	det	The,basis
R3358	T11918	T11919	nsubj	basis,was
R3359	T11777	T11775	conj	obesity,growth
R3360	T11920	T11918	prep	of,basis
R3361	T11921	T11922	det	each,interaction
R3362	T11778	T11764	prep	between,displayed
R3363	T11922	T11920	pobj	interaction,of
R3364	T11923	T11924	det	an,increase
R3365	T11779	T11780	det	the,sexes
R3366	T11924	T11919	attr	increase,was
R3367	T11925	T11924	prep	in,increase
R3368	T11926	T11927	det	the,males
R3369	T11780	T11778	pobj	sexes,between
R3370	T11927	T11925	pobj	males,in
R3371	T11781	T11764	punct	.,displayed
R3372	T11928	T11924	cc	and,increase
R3373	T11929	T11930	det	a,decrease
R3374	T11930	T11924	conj	decrease,increase
R3375	T11931	T11930	prep	in,decrease
R3376	T11783	T11784	prep	In,demonstrated
R3377	T11932	T11931	pobj	females,in
R3378	T11933	T11919	punct	.,was
R3379	T11935	T11936	prep	In,observed
R3380	T11785	T11783	amod	general,In
R3381	T11937	T11938	poss	our,analysis
R3382	T11938	T11935	pobj	analysis,In
R3383	T11939	T11938	prep	of,analysis
R3384	T11786	T11784	punct	", ",demonstrated
R3385	T11940	T11941	det	the,strains
R3386	T11941	T11939	pobj	strains,of
R3387	T11942	T11941	nmod	HGC,strains
R3388	T11787	T11784	nsubj	males,demonstrated
R3389	T11943	T11942	punct	", ",HGC
R3390	T11944	T11942	conj	HG11,HGC
R3391	T11788	T11789	det	a,increase
R3392	T11945	T11944	cc	and,HG11
R3393	T11946	T11944	conj	HG17,HG11
R3394	T11947	T11936	punct	", ",observed
R3395	T11789	T11784	dobj	increase,demonstrated
R3396	T11948	T11949	amod	concordant,results
R3397	T11949	T11936	nsubjpass	results,observed
R3398	T11950	T11936	auxpass	were,observed
R3399	T11951	T11936	advcl	measuring,observed
R3400	T11952	T11951	dobj	adiposity,measuring
R3401	T11953	T11951	advcl	using,measuring
R3402	T11954	T11955	amod	chemical,extraction
R3403	T11955	T11953	dobj	extraction,using
R3404	T11956	T11955	compound	lipid,extraction
R3405	T11790	T11791	nummod	5,%
R3406	T11957	T11953	cc	and,using
R3407	T11958	T11953	conj	weighing,using
R3408	T11791	T11789	compound	%,increase
R3409	T11792	T11784	cc	and,demonstrated
R3410	T11959	T11960	compound	fat,pad
R3411	T11960	T11961	compound	pad,mass
R3412	T11793	T11794	nsubj	females,decrease
R3413	T11961	T11958	dobj	mass,weighing
R3414	T11962	T11936	punct	.,observed
R3415	T11794	T11784	conj	decrease,demonstrated
R3416	T11964	T11965	det	The,correlation
R3417	T11795	T11794	det	a,decrease
R3418	T11965	T11967	nsubj	correlation,was
R3419	T11796	T11797	nummod	5,%
R3420	T11966	T11965	amod	phenotypic,correlation
R3421	T11797	T11794	compound	%,decrease
R3422	T11968	T11965	prep	between,correlation
R3423	T11969	T11970	compound	carcass,fat
R3424	T11798	T11794	prep	in,decrease
R3425	T11970	T11968	pobj	fat,between
R3426	T11971	T11970	punct	(,fat
R3427	T11799	T11800	det	all,traits
R3428	T11972	T11970	appos	FAT,fat
R3429	T11973	T11965	punct	),correlation
R3430	T11800	T11798	pobj	traits,in
R3431	T11974	T11965	prep	as,correlation
R3432	T11975	T11976	det	a,percent
R3433	T11801	T11802	npadvmod	growth,related
R3434	T11976	T11974	pobj	percent,as
R3435	T11977	T11976	prep	of,percent
R3436	T11978	T11979	det	the,weight
R3437	T11802	T11800	amod	related,traits
R3438	T11979	T11977	pobj	weight,of
R3439	T11980	T11979	amod	empty,weight
R3440	T11803	T11802	punct	-,related
R3441	T11981	T11979	compound	carcass,weight
R3442	T11982	T11979	punct	(,weight
R3443	T11983	T11979	appos	ECW,weight
R3444	T11804	T11805	punct	(,Table
R3445	T11984	T11983	punct	;,ECW
R3446	T11985	T11983	appos	weight,ECW
R3447	T11986	T11985	prep	of,weight
R3448	T11805	T11784	parataxis	Table,demonstrated
R3449	T11987	T11988	amod	total,body
R3450	T11988	T11986	pobj	body,of
R3451	T11989	T11985	punct	(,weight
R3452	T11990	T11985	prep	including,weight
R3453	T11991	T11990	pobj	organs,including
R3454	T11992	T11985	punct	),weight
R3455	T11993	T11985	cc	minus,weight
R3456	T11806	T11805	nummod	4,Table
R3457	T11994	T11995	det	the,head
R3458	T11995	T11985	conj	head,weight
R3459	T11996	T11995	cc	and,head
R3460	T11807	T11805	punct	),Table
R3461	T11997	T11998	amod	gastrointestinal,tract
R3462	T11998	T11995	conj	tract,head
R3463	T11999	T11985	punct	),weight
R3464	T11808	T11784	punct	.,demonstrated
R3465	T12000	T11965	punct	(,correlation
R3466	T12001	T12002	compound	%,FAT
R3467	T12002	T11965	appos	FAT,correlation
R3468	T11810	T11811	nsubj	Most,were
R3469	T12003	T11965	punct	),correlation
R3470	T12004	T11965	acl	determined,correlation
R3471	T12005	T12004	prep	by,determined
R3472	T11812	T11810	prep	of,Most
R3473	T12006	T12007	amod	chemical,analysis
R3474	T12007	T12005	pobj	analysis,by
R3475	T12008	T12007	cc	and,analysis
R3476	T12009	T12007	conj	AI,analysis
R3477	T11813	T11814	det	these,differences
R3478	T12010	T12004	punct	", ",determined
R3479	T11814	T11812	pobj	differences,of
R3480	T12011	T12004	advcl	using,determined
R3481	T12012	T12011	dobj	data,using
R3482	T12013	T12012	prep	from,data
R3483	T12014	T12015	det	all,lines
R3484	T11815	T11811	punct	", ",were
R3485	T12015	T12013	pobj	lines,from
R3486	T12016	T12015	nummod	three,lines
R3487	T12017	T12015	punct	(,lines
R3488	T11816	T11811	advmod	however,were
R3489	T12018	T12015	appos	HGC,lines
R3490	T12019	T12018	punct	", ",HGC
R3491	T12020	T12018	conj	HG11,HGC
R3492	T11817	T11811	punct	", ",were
R3493	T12021	T12020	cc	and,HG11
R3494	T12022	T12020	conj	HG17,HG11
R3495	T11818	T11811	neg	not,were
R3496	T12023	T11967	punct	),was
R3497	T12024	T11967	punct	", ",was
R3498	T12025	T11967	attr	0.92,was
R3499	T11819	T11811	acomp	significant,were
R3500	T12026	T11967	punct	.,was
R3501	T11820	T11811	prep	at,were
R3502	T12028	T12029	det	These,data
R3503	T12029	T12030	nsubj	data,suggest
R3504	T12031	T12032	mark	that,is
R3505	T12032	T12030	ccomp	is,suggest
R3506	T12033	T12034	amod	individual,dissection
R3507	T11821	T11822	det	a,0.005
R3508	T12034	T12032	nsubj	dissection,is
R3509	T12035	T12036	compound	fat,pad
R3510	T12036	T12034	compound	pad,dissection
R3511	T12037	T12038	det	an,proxy
R3512	T11822	T11820	pobj	0.005,at
R3513	T12038	T12032	attr	proxy,is
R3514	T12039	T12038	amod	excellent,proxy
R3515	T11823	T11822	amod	critical,0.005
R3516	T12040	T12038	prep	for,proxy
R3517	T12041	T12040	pcomp	measuring,for
R3518	T12042	T12043	amod	whole,body
R3519	T11824	T11822	nsubj	P,0.005
R3520	T12043	T12044	compound	body,adiposity
R3521	T12044	T12041	dobj	adiposity,measuring
R3522	T12045	T12032	cc	and,is
R3523	T11825	T11822	punct	<,0.005
R3524	T12046	T12032	conj	provides,is
R3525	T12047	T12048	det	a,technique
R3526	T11826	T11811	punct	", ",were
R3527	T12048	T12046	dobj	technique,provides
R3528	T11827	T11828	mark	although,were
R3529	T12049	T12050	advmod	much,more
R3530	T12050	T12051	advmod	more,sensitive
R3531	T11828	T11811	advcl	were,were
R3532	T12051	T12048	amod	sensitive,technique
R3533	T11829	T11830	advmod	almost,all
R3534	T12052	T12053	aux	to,measure
R3535	T12053	T12048	advcl	measure,technique
R3536	T12054	T12055	compound	fat,accumulation
R3537	T11830	T11828	nsubj	all,were
R3538	T12055	T12053	dobj	accumulation,measure
R3539	T12056	T12053	prep	in,measure
R3540	T12057	T12058	amod	specific,regions
R3541	T11831	T11828	prep	at,were
R3542	T12058	T12056	pobj	regions,in
R3543	T12059	T12058	compound	body,regions
R3544	T11832	T11833	det	a,0.05
R3545	T12060	T12030	punct	.,suggest
R3546	T11833	T11831	pobj	0.05,at
R3547	T12062	T12063	compound	HG11,females
R3548	T12063	T12064	nsubj	females,displayed
R3549	T11834	T11833	amod	nominal,0.05
R3550	T11835	T11833	nsubj	P,0.05
R3551	T11836	T11833	punct	<,0.05
R3552	T12065	T12066	amod	slight,increases
R3553	T11837	T11811	punct	.,were
R3554	T12066	T12064	dobj	increases,displayed
R3555	T12067	T12066	prep	in,increases
R3556	T12068	T12069	det	all,pads
R3557	T12069	T12067	pobj	pads,in
R3558	T12070	T12069	compound	fat,pads
R3559	T12071	T12069	punct	(,pads
R3560	T12072	T12069	prep	except,pads
R3561	T11839	T11840	advcl	Following,displayed
R3562	T12073	T12072	pobj	MFP,except
R3563	T12074	T12069	punct	),pads
R3564	T12075	T12069	cc	and,pads
R3565	T12076	T12069	conj	AI,pads
R3566	T11841	T11842	det	the,trend
R3567	T12077	T12064	punct	", ",displayed
R3568	T12078	T12079	mark	although,was
R3569	T12079	T12064	advcl	was,displayed
R3570	T12080	T12079	punct	", ",was
R3571	T12081	T12082	advmod	only,increase
R3572	T11842	T11839	dobj	trend,Following
R3573	T12082	T12079	nsubj	increase,was
R3577	T11843	T11842	amod	same,trend
R3580	T12088	T12079	acomp	significant,was
R3581	T11844	T11840	punct	", ",displayed
R3586	T11845	T11840	nsubj	males,displayed
R3587	T12093	T12064	punct	.,displayed
R3588	T11846	T11847	det	an,increase
R3589	T12095	T12096	prep	In,show
R3590	T12097	T12095	pobj	contrast,In
R3591	T12098	T12096	punct	", ",show
R3592	T12099	T12100	compound	HG11,males
R3593	T11847	T11840	dobj	increase,displayed
R3594	T12100	T12096	nsubj	males,show
R3595	T12101	T12096	aux	did,show
R3596	T12102	T12096	neg	not,show
R3597	T11848	T11847	prep	in,increase
R3598	T12103	T12104	det	a,difference
R3599	T12104	T12096	dobj	difference,show
R3600	T12105	T12104	prep	in,difference
R3601	T11849	T11850	compound	tail,length
R3602	T12106	T12107	compound	fat,mass
R3603	T12107	T12105	pobj	mass,in
R3604	T12108	T12104	acl	leading,difference
R3605	T11850	T11848	pobj	length,in
R3606	T12109	T12108	prep	to,leading
R3607	T12110	T12111	det	a,interaction
R3608	T12111	T12109	pobj	interaction,to
R3609	T12112	T12111	amod	significant,interaction
R3610	T12113	T12111	nmod	strain,interaction
R3611	T12114	T12113	prep	by,strain
R3612	T12115	T12114	pobj	sex,by
R3613	T12116	T12117	punct	(,0.008
R3614	T12117	T12111	parataxis	0.008,interaction
R3615	T11851	T11847	cc	and,increase
R3616	T12118	T12117	nsubj	P,0.008
R3617	T12119	T12117	punct	=,0.008
R3618	T12120	T12117	punct	),0.008
R3619	T11852	T11853	det	a,increase
R3620	T12121	T12111	prep	for,interaction
R3621	T12122	T12121	pobj	AI,for
R3622	T12123	T12124	punct	(,shown
R3623	T12124	T12108	parataxis	shown,leading
R3624	T12125	T12124	nsubj	data,shown
R3625	T12170	T12169	pobj	ECW,of
R3626	T12126	T12124	neg	not,shown
R3627	T12127	T12124	punct	),shown
R3628	T12128	T12096	punct	.,show
R3629	T12130	T12131	advcl	Identical,displayed
R3630	T12132	T12130	prep	to,Identical
R3631	T12171	T12168	punct	(,percent
R3632	T12133	T12134	det	the,results
R3633	T12134	T12132	pobj	results,to
R3634	T12172	T12173	compound	%,ASH
R3635	T12135	T12134	acl	obtained,results
R3636	T12173	T12168	appos	ASH,percent
R3637	T12136	T12135	advcl	using,obtained
R3638	T12174	T12158	punct	),had
R3639	T12137	T12138	compound	fat,pad
R3640	T12138	T12139	compound	pad,weights
R3641	T12139	T12136	dobj	weights,using
R3642	T12175	T12158	cc	and,had
R3643	T12140	T12131	punct	;,displayed
R3644	T12141	T12142	amod	female,carcasses
R3645	T12142	T12131	nsubj	carcasses,displayed
R3646	T12176	T12177	amod	female,carcasses
R3647	T12143	T12142	compound	HG11,carcasses
R3648	T12144	T12145	det	an,increase
R3649	T12177	T12178	nsubj	carcasses,displayed
R3650	T12145	T12131	dobj	increase,displayed
R3651	T12146	T12145	prep	in,increase
R3652	T12147	T12148	compound	%,FAT
R3653	T12148	T12146	pobj	FAT,in
R3654	T12149	T12150	punct	(,Table
R3655	T12178	T12158	conj	displayed,had
R3656	T12150	T12131	parataxis	Table,displayed
R3657	T12151	T12150	nummod	6,Table
R3658	T12179	T12180	amod	lower,levels
R3659	T12152	T12150	punct	),Table
R3660	T12153	T12131	punct	.,displayed
R3661	T12155	T12156	nmod	HG11,carcasses
R3662	T12180	T12178	dobj	levels,displayed
R3663	T12181	T12180	prep	of,levels
R3664	T12156	T12158	nsubj	carcasses,had
R3665	T12182	T12181	pobj	H2O,of
R3666	T12157	T12156	amod	male,carcasses
R3667	T12183	T12182	cc	and,H2O
R3668	T12159	T12160	amod	higher,levels
R3669	T12160	T12158	dobj	levels,had
R3670	T12161	T12162	compound	carcass,ash
R3672	T12162	T12160	appos	ash,levels
R3673	T12163	T12162	punct	(,ash
R3674	T12164	T12162	appos	ASH,ash
R3675	T12185	T12186	punct	(,Table
R3676	T12165	T12160	punct	),levels
R3677	T12166	T12160	prep	as,levels
R3678	T12186	T12178	parataxis	Table,displayed
R3679	T12167	T12168	det	a,percent
R3680	T12168	T12166	pobj	percent,as
R3681	T12169	T12168	prep	of,percent
R3682	T12187	T12186	nummod	6,Table
R3683	T12188	T12186	punct	),Table
R3684	T12189	T12178	punct	.,displayed
R3685	T12276	T12274	amod	specific,QTL
R3686	T12191	T12192	nmod	Strains,interactions
R3687	T12277	T12276	punct	-,specific
R3688	T12278	T12274	prep	with,QTL
R3689	T12279	T12280	amod	opposing,action
R3690	T12280	T12278	pobj	action,with
R3691	T12281	T12266	punct	.,be
R3692	T12192	T12195	nsubjpass	interactions,identified
R3693	T12193	T12191	prep	by,Strains
R3694	T12194	T12193	pobj	sex,by
R3695	T12285	T12286	prep	In,associated
R3696	T12287	T12288	det	the,intercross
R3697	T12196	T12197	punct	(,0.005
R3698	T12288	T12285	pobj	intercross,In
R3699	T12289	T12288	amod	original,intercross
R3700	T12197	T12192	parataxis	0.005,interactions
R3701	T12290	T12291	compound	CAST,alleles
R3702	T12291	T12286	nsubjpass	alleles,associated
R3703	T12292	T12291	prep	at,alleles
R3704	T12198	T12197	nsubj	P,0.005
R3705	T12293	T12294	compound	MMU17,markers
R3706	T12294	T12292	pobj	markers,at
R3707	T12295	T12286	auxpass	were,associated
R3708	T12199	T12197	punct	<,0.005
R3709	T12296	T12286	prep	with,associated
R3710	T12297	T12296	pobj	decreases,with
R3711	T12298	T12297	prep	in,decreases
R3712	T12299	T12300	compound	femur,length
R3713	T12300	T12298	pobj	length,in
R3714	T12301	T12300	punct	", ",length
R3715	T12302	T12300	conj	ASH,length
R3716	T12303	T12302	cc	and,ASH
R3717	T12200	T12197	punct	),0.005
R3718	T12304	T12302	conj	PROT,ASH
R3719	T12305	T12306	punct	[,24
R3720	T12201	T12195	auxpass	were,identified
R3721	T12306	T12286	parataxis	24,associated
R3722	T12202	T12195	prep	for,identified
R3723	T12307	T12306	punct	],24
R3724	T12203	T12202	pobj	H2O,for
R3725	T12308	T12286	cc	and,associated
R3726	T12309	T12310	amod	similar,results
R3727	T12310	T12311	nsubjpass	results,seen
R3728	T12204	T12203	punct	", ",H2O
R3729	T12311	T12286	conj	seen,associated
R3730	T12312	T12311	auxpass	were,seen
R3731	T12313	T12311	prep	in,seen
R3732	T12205	T12206	compound	%,H2O
R3733	T12314	T12315	compound	HG17,mice
R3734	T12315	T12313	pobj	mice,in
R3735	T12206	T12203	conj	H2O,H2O
R3736	T12316	T12286	punct	.,associated
R3737	T12207	T12206	punct	", ",H2O
R3738	T12318	T12319	advmod	Interestingly,were
R3739	T12320	T12319	punct	", ",were
R3740	T12208	T12209	compound	%,FAT
R3741	T12321	T12322	det	both,sexes
R3742	T12322	T12319	nsubj	sexes,were
R3743	T12323	T12319	acomp	heavier,were
R3744	T12209	T12206	conj	FAT,H2O
R3745	T12324	T12323	prep	at,heavier
R3746	T12325	T12324	pobj	2WK,at
R3747	T12326	T12327	punct	(,0.0342
R3748	T12210	T12209	punct	", ",FAT
R3749	T12327	T12323	parataxis	0.0342,heavier
R3750	T12328	T12329	dep	males,0.0045
R3751	T12211	T12209	conj	ASH,FAT
R3752	T12329	T12327	dep	0.0045,0.0342
R3753	T12330	T12329	punct	", ",0.0045
R3754	T12212	T12211	cc	and,ASH
R3755	T12331	T12329	nsubj	P,0.0045
R3756	T12332	T12329	punct	=,0.0045
R3757	T12333	T12327	punct	;,0.0342
R3758	T12213	T12211	conj	PROT,ASH
R3759	T12334	T12327	dep	females,0.0342
R3760	T12335	T12327	punct	", ",0.0342
R3761	T12214	T12215	punct	(,shown
R3762	T12336	T12327	nsubj	P,0.0342
R3763	T12337	T12327	punct	=,0.0342
R3764	T12338	T12327	punct	),0.0342
R3765	T12339	T12323	punct	", ",heavier
R3766	T12340	T12323	cc	but,heavier
R3767	T12341	T12323	conj	lighter,heavier
R3768	T12342	T12341	prep	at,lighter
R3769	T12215	T12195	parataxis	shown,identified
R3770	T12343	T12342	pobj	9WK,at
R3771	T12344	T12319	punct	", ",were
R3772	T12345	T12319	advcl	leading,were
R3773	T12216	T12215	nsubj	data,shown
R3774	T12346	T12345	prep	to,leading
R3775	T12347	T12348	advmod	substantially,lower
R3776	T12348	T12349	amod	lower,G26
R3777	T12217	T12215	neg	not,shown
R3778	T12349	T12346	pobj	G26,to
R3779	T12350	T12349	cc	and,G26
R3780	T12218	T12215	punct	),shown
R3781	T12351	T12349	conj	G29,G26
R3782	T12352	T12353	punct	(,Table
R3783	T12353	T12319	parataxis	Table,were
R3784	T12219	T12195	punct	.,identified
R3785	T12354	T12353	nummod	4,Table
R3786	T12355	T12353	punct	),Table
R3787	T12356	T12319	punct	.,were
R3788	T12221	T12222	mark	If,is
R3789	T12358	T12359	prep	In,ranged
R3790	T12360	T12358	amod	general,In
R3791	T12222	T12228	advcl	is,be
R3792	T12361	T12362	compound	growth,differences
R3793	T12362	T12359	nsubj	differences,ranged
R3794	T12223	T12224	det	the,phenotype
R3795	T12363	T12359	prep	between,ranged
R3796	T12364	T12365	nummod	5,%
R3797	T12365	T12363	pobj	%,between
R3798	T12224	T12222	nsubj	phenotype,is
R3799	T12366	T12365	cc	and,%
R3800	T12367	T12368	nummod	15,%
R3801	T12368	T12365	conj	%,%
R3802	T12225	T12224	amod	aggregate,phenotype
R3803	T12369	T12365	amod	lower,%
R3804	T12370	T12359	prep	in,ranged
R3805	T12226	T12224	prep	in,phenotype
R3806	T12371	T12372	amod	congenic,mice
R3807	T12372	T12370	pobj	mice,in
R3808	T12227	T12226	pobj	HG11,in
R3809	T12373	T12359	punct	.,ranged
R3810	T12375	T12376	det	Both,sexes
R3811	T12229	T12222	prep	due,is
R3812	T12376	T12377	nsubj	sexes,had
R3813	T12378	T12379	amod	significant,reductions
R3814	T12379	T12377	dobj	reductions,had
R3815	T12380	T12379	prep	in,reductions
R3816	T12381	T12382	compound	length,traits
R3817	T12230	T12229	pcomp	to,due
R3818	T12231	T12232	det	a,locus
R3819	T12382	T12380	pobj	traits,in
R3820	T12232	T12229	pobj	locus,due
R3821	T12383	T12377	advcl	relative,had
R3822	T12384	T12383	prep	to,relative
R3823	T12385	T12386	compound	control,mice
R3824	T12233	T12232	amod	single,locus
R3825	T12386	T12384	pobj	mice,to
R3826	T12387	T12377	punct	.,had
R3827	T12234	T12228	punct	", ",be
R3828	T12389	T12390	nsubjpass	NA,reduced
R3829	T12235	T12236	poss	its,function
R3830	T12391	T12390	auxpass	was,reduced
R3831	T12392	T12390	prep	by,reduced
R3832	T12393	T12394	nummod	2.7,%
R3833	T12236	T12228	nsubj	function,be
R3834	T12394	T12392	pobj	%,by
R3835	T12395	T12396	punct	(,0.0186
R3836	T12237	T12228	aux	may,be
R3837	T12238	T12239	aux	to,disrupt
R3838	T12396	T12394	parataxis	0.0186,%
R3839	T12397	T12396	nsubj	P,0.0186
R3840	T12239	T12228	xcomp	disrupt,be
R3841	T12398	T12396	punct	=,0.0186
R3842	T12399	T12396	punct	),0.0186
R3843	T12400	T12394	cc	and,%
R3844	T12240	T12241	compound	energy,partitioning
R3845	T12401	T12402	nummod	3.4,%
R3846	T12402	T12394	conj	%,%
R3847	T12403	T12390	prep	in,reduced
R3848	T12241	T12239	dobj	partitioning,disrupt
R3849	T12404	T12403	pobj	males,in
R3850	T12405	T12404	cc	and,males
R3851	T12242	T12239	prep	by,disrupt
R3852	T12406	T12404	conj	females,males
R3853	T12407	T12390	punct	", ",reduced
R3854	T12243	T12242	pcomp	decreasing,by
R3855	T12408	T12390	advmod	respectively,reduced
R3856	T12409	T12410	punct	(,Table
R3857	T12410	T12390	parataxis	Table,reduced
R3858	T12244	T12245	det	the,deposition
R3859	T12411	T12410	nummod	4,Table
R3860	T12412	T12410	punct	),Table
R3861	T12245	T12243	dobj	deposition,decreasing
R3862	T12413	T12390	punct	.,reduced
R3863	T12246	T12245	prep	of,deposition
R3864	T12415	T12416	prep	In,reduced
R3865	T12417	T12415	pobj	addition,In
R3866	T12418	T12416	punct	", ",reduced
R3867	T12419	T12416	nsubjpass	tail,reduced
R3868	T12420	T12416	auxpass	was,reduced
R3869	T12421	T12416	prep	by,reduced
R3870	T12247	T12248	amod	lean,tissue
R3871	T12422	T12423	advmod	approximately,6
R3872	T12423	T12424	nummod	6,%
R3873	T12424	T12421	pobj	%,by
R3874	T12248	T12246	pobj	tissue,of
R3875	T12425	T12416	prep	in,reduced
R3876	T12426	T12427	det	both,sexes
R3877	T12249	T12243	cc	and,decreasing
R3878	T12427	T12425	pobj	sexes,in
R3879	T12428	T12429	punct	(,Table
R3880	T12429	T12416	parataxis	Table,reduced
R3881	T12250	T12243	conj	increasing,decreasing
R3882	T12430	T12429	nummod	4,Table
R3883	T12431	T12429	punct	),Table
R3884	T12251	T12252	compound	lipid,accumulation
R3885	T12432	T12416	punct	.,reduced
R3886	T12252	T12250	dobj	accumulation,increasing
R3887	T12434	T12435	prep	In,displayed
R3888	T12436	T12434	amod	general,In
R3889	T12253	T12252	prep	in,accumulation
R3890	T12437	T12435	punct	", ",displayed
R3891	T12438	T12439	compound	HG17,mice
R3892	T12254	T12253	pobj	females,in
R3893	T12439	T12435	nsubj	mice,displayed
R3894	T12440	T12435	dobj	increases,displayed
R3895	T12441	T12440	prep	in,increases
R3896	T12255	T12243	punct	", ",decreasing
R3897	T12442	T12443	det	all,pads
R3898	T12443	T12441	pobj	pads,in
R3899	T12444	T12443	compound	fat,pads
R3900	T12256	T12257	mark	while,having
R3901	T12445	T12443	punct	(,pads
R3902	T12446	T12443	prep	except,pads
R3903	T12257	T12243	advcl	having,decreasing
R3904	T12447	T12446	pobj	MFP,except
R3905	T12448	T12443	punct	),pads
R3906	T12258	T12259	det	the,action
R3907	T12449	T12443	punct	", ",pads
R3908	T12450	T12443	conj	TF,pads
R3909	T12451	T12450	cc	and,TF
R3910	T12259	T12257	dobj	action,having
R3911	T12452	T12450	conj	AI,TF
R3912	T12453	T12454	punct	(,Table
R3913	T12260	T12259	amod	opposite,action
R3914	T12454	T12435	parataxis	Table,displayed
R3915	T12455	T12454	nummod	5,Table
R3916	T12456	T12454	punct	),Table
R3917	T12261	T12257	prep	in,having
R3918	T12457	T12435	punct	.,displayed
R3919	T12459	T12460	advmod	However,were
R3920	T12461	T12460	punct	", ",were
R3921	T12462	T12460	nsubj	none,were
R3922	T12262	T12261	pobj	males,in
R3923	T12463	T12462	prep	of,none
R3924	T12464	T12465	det	these,differences
R3925	T12465	T12463	pobj	differences,of
R3926	T12263	T12228	punct	.,be
R3927	T12466	T12460	acomp	significant,were
R3928	T12467	T12460	prep	at,were
R3929	T12265	T12266	advmod	However,be
R3930	T12468	T12469	amod	critical,0.005
R3931	T12469	T12467	pobj	0.005,at
R3934	T12267	T12266	punct	", ",be
R3937	T12268	T12266	nsubj	it,be
R3938	T12476	T12474	pobj	addition,In
R3939	T12477	T12475	punct	", ",possessed
R3940	T12269	T12266	aux	may,be
R3941	T12478	T12479	nmod	HG17,carcasses
R3942	T12479	T12475	nsubj	carcasses,possessed
R3943	T12480	T12479	amod	male,carcasses
R3944	T12270	T12266	advmod	also,be
R3945	T12481	T12482	amod	lower,levels
R3946	T12482	T12475	dobj	levels,possessed
R3947	T12483	T12482	prep	of,levels
R3948	T12271	T12266	prep	due,be
R3949	T12272	T12271	pcomp	to,due
R3950	T12484	T12483	pobj	H2O,of
R3951	T12485	T12484	cc	and,H2O
R3952	T12486	T12484	conj	ASH,H2O
R3953	T12273	T12274	amod	distinct,QTL
R3954	T12274	T12271	pobj	QTL,due
R3955	T12275	T12276	npadvmod	sex,specific
R3956	T12487	T12475	punct	", ",possessed
R3957	T12488	T12489	mark	while,contained
R3958	T12489	T12475	advcl	contained,possessed
R3959	T12490	T12491	amod	female,carcasses
R3960	T12491	T12489	nsubj	carcasses,contained
R3961	T12492	T12493	amod	lower,levels
R3962	T12493	T12489	dobj	levels,contained
R3963	T12494	T12493	prep	of,levels
R3964	T12495	T12496	compound	%,H2O
R3965	T12496	T12494	pobj	H2O,of
R3966	T12497	T12496	punct	", ",H2O
R3967	T12498	T12496	conj	ASH,H2O
R3968	T12499	T12498	punct	", ",ASH
R3969	T12500	T12501	compound	%,ASH
R3970	T12501	T12498	conj	ASH,ASH
R3971	T12502	T12501	cc	and,ASH
R3972	T12503	T12504	compound	%,PROT
R3973	T12504	T12501	conj	PROT,ASH
R3974	T12505	T12506	punct	(,Table
R3975	T12506	T12475	parataxis	Table,possessed
R3976	T12507	T12506	nummod	6,Table
R3977	T12508	T12506	punct	),Table
R3978	T12509	T12475	punct	.,possessed
R3987	T13271	T13272	nmod	MMU,2
R3988	T13272	T13273	nummod	2,sequencing
R3989	T13274	T13272	punct	", ",2
R3990	T13275	T13272	conj	9,2
R3991	T13276	T13275	punct	", ",9
R3992	T13277	T13275	conj	11,9
R3993	T13278	T13277	cc	and,11
R3994	T13279	T13277	conj	17,11
R3995	T13280	T13281	compound	hg,modifier
R3996	T13281	T13273	compound	modifier,sequencing
R3997	T13282	T13283	compound	candidate,gene
R3998	T13283	T13273	compound	gene,sequencing
R3999	T13285	T13286	det	The,phenotype
R4000	T13286	T13288	nsubj	phenotype,is
R4001	T13287	T13286	compound	HG,phenotype
R4002	T13288	T13289	ccomp	is,reasoned
R4003	T13290	T13288	prep	due,is
R4004	T13291	T13290	pcomp	to,due
R4005	T13292	T13293	det	the,deletion
R4006	T13293	T13290	pobj	deletion,due
R4007	T13294	T13293	prep	of,deletion
R4008	T13295	T13294	pobj	Socs2,of
R4009	T13296	T13289	punct	", ",reasoned
R4010	T13297	T13289	advmod	therefore,reasoned
R4011	T13298	T13289	nsubj	we,reasoned
R4012	T13299	T13300	mark	that,represent
R4013	T13300	T13289	ccomp	represent,reasoned
R4014	T13301	T13300	nsubj	QTL,represent
R4015	T13302	T13301	prep	on,QTL
R4016	T13303	T13304	nmod	MMU,2
R4017	T13304	T13302	pobj	2,on
R4018	T13305	T13304	punct	", ",2
R4019	T13306	T13304	conj	9,2
R4020	T13307	T13306	punct	", ",9
R4021	T13308	T13306	conj	11,9
R4022	T13309	T13308	cc	and,11
R4023	T13310	T13308	conj	17,11
R4024	T13311	T13301	acl	interacting,QTL
R4025	T13312	T13311	prep	with,interacting
R4026	T13313	T13312	pobj	hg,with
R4027	T13314	T13300	advmod	possibly,represent
R4028	T13315	T13300	dobj	variation,represent
R4029	T13316	T13315	prep	within,variation
R4030	T13317	T13316	pobj	genes,within
R4031	T13318	T13317	acl	participating,genes
R4032	T13319	T13318	prep	in,participating
R4033	T13320	T13321	amod	various,aspects
R4034	T13321	T13319	pobj	aspects,in
R4035	T13322	T13321	prep	of,aspects
R4036	T13323	T13324	compound	Gh,function
R4037	T13324	T13322	pobj	function,of
R4038	T13325	T13289	punct	.,reasoned
R4039	T13327	T13328	aux	To,select
R4040	T13328	T13329	advcl	select,identified
R4041	T13330	T13331	compound	candidate,genes
R4042	T13331	T13328	dobj	genes,select
R4043	T13332	T13331	prep	for,genes
R4044	T13333	T13332	pobj	sequencing,for
R4045	T13334	T13329	nsubj	we,identified
R4046	T13335	T13329	dobj	genes,identified
R4047	T13336	T13335	acl	known,genes
R4048	T13337	T13338	aux	to,be
R4049	T13338	T13336	xcomp	be,known
R4050	T13339	T13336	cc	or,known
R4051	T13340	T13336	conj	potentially,known
R4052	T13341	T13340	dep	involved,potentially
R4053	T13342	T13341	prep	in,involved
R4054	T13343	T13344	compound	Gh,signaling
R4055	T13344	T13342	pobj	signaling,in
R4056	T13345	T13336	punct	", ",known
R4057	T13346	T13336	conj	are,known
R4058	T13347	T13346	acomp	responsive,are
R4059	T13348	T13347	prep	to,responsive
R4060	T13349	T13348	pobj	Gh,to
R4061	T13350	T13346	cc	or,are
R4062	T13351	T13352	dep	that,propagate
R4063	T13352	T13346	conj	propagate,are
R4064	T13353	T13354	amod	downstream,functions
R4065	T13354	T13352	dobj	functions,propagate
R4066	T13355	T13354	compound	Gh,functions
R4067	T13356	T13329	punct	.,identified
R4068	T13358	T13359	compound	Forty,four
R4069	T13359	T13361	nummod	four,genes
R4070	T13360	T13359	punct	-,four
R4071	T13361	T13365	nsubjpass	genes,identified
R4072	T13362	T13363	compound	hg,modifier
R4073	T13363	T13361	compound	modifier,genes
R4074	T13364	T13361	compound	candidate,genes
R4075	T13366	T13365	auxpass	were,identified
R4076	T13367	T13365	prep	from,identified
R4077	T13368	T13369	amod	primary,literature
R4078	T13369	T13367	pobj	literature,from
R4079	T13370	T13369	punct	", ",literature
R4080	T13371	T13369	conj	reviews,literature
R4081	T13372	T13371	cc	and,reviews
R4082	T13373	T13374	compound	book,chapters
R4083	T13374	T13371	conj	chapters,reviews
R4084	T13375	T13365	cc	and,identified
R4085	T13376	T13365	conj	coordinated,identified
R4086	T13377	T13376	advcl	using,coordinated
R4087	T13378	T13379	det	the,software
R4088	T13379	T13377	dobj	software,using
R4089	T13380	T13379	nmod	GenMAPP,software
R4090	T13381	T13380	punct	(,GenMAPP
R4091	T13382	T13383	compound	Gene,MicroArray
R4092	T13383	T13384	compound	MicroArray,Profiler
R4093	T13384	T13380	appos	Profiler,GenMAPP
R4094	T13385	T13384	compound	Pathway,Profiler
R4095	T13386	T13379	punct	),software
R4096	T13387	T13388	compound	pathway,building
R4097	T13388	T13379	compound	building,software
R4098	T13389	T13390	punct	(,Figure
R4099	T13390	T13376	parataxis	Figure,coordinated
R4100	T13391	T13390	nummod	5,Figure
R4101	T13392	T13390	punct	),Figure
R4102	T13393	T13365	punct	.,identified
R4103	T13395	T13396	det	The,region
R4104	T13396	T13398	nsubjpass	region,sequenced
R4105	T13397	T13396	compound	coding,region
R4106	T13399	T13396	prep	of,region
R4107	T13400	T13401	det	each,gene
R4108	T13401	T13399	pobj	gene,of
R4109	T13402	T13398	auxpass	was,sequenced
R4110	T13403	T13398	prep	from,sequenced
R4111	T13404	T13405	det	the,strain
R4112	T13405	T13403	pobj	strain,from
R4113	T13406	T13405	compound	CAST,strain
R4114	T13407	T13398	cc	and,sequenced
R4115	T13408	T13398	conj	compared,sequenced
R4116	T13409	T13408	prep	to,compared
R4117	T13410	T13411	det	the,sequence
R4118	T13411	T13409	pobj	sequence,to
R4119	T13412	T13413	advmod	publicly,available
R4120	T13413	T13411	amod	available,sequence
R4121	T13414	T13411	compound	B6,sequence
R4122	T13415	T13416	aux	to,identify
R4123	T13416	T13408	advcl	identify,compared
R4124	T13417	T13416	dobj	polymorphisms,identify
R4125	T13418	T13419	punct	(,File
R4126	T13419	T13408	parataxis	File,compared
R4127	T13420	T13419	amod	Additional,File
R4128	T13421	T13419	nummod	4,File
R4129	T13422	T13419	punct	),File
R4130	T13423	T13398	punct	.,sequenced
R4131	T13425	T13426	det	A,total
R4132	T13426	T13427	nsubjpass	total,sequenced
R4133	T13428	T13426	prep	of,total
R4134	T13429	T13430	nummod	94.492,kbp
R4135	T13430	T13428	pobj	kbp,of
R4136	T13431	T13427	auxpass	was,sequenced
R4137	T13432	T13433	punct	(,CDS
R4138	T13433	T13427	parataxis	CDS,sequenced
R4139	T13434	T13435	nummod	75.378,kbp
R4140	T13435	T13433	compound	kbp,CDS
R4141	T13436	T13433	cc	and,CDS
R4142	T13437	T13438	nummod	19.114,Kbp
R4143	T13438	T13439	nmod	Kbp,region
R4144	T13439	T13433	conj	region,CDS
R4145	T13440	T13438	nummod	5,Kbp
R4146	T13441	T13440	punct	',5
R4147	T13442	T13438	cc	and,Kbp
R4148	T13443	T13438	conj	3,Kbp
R4149	T13444	T13443	punct	',3
R4150	T13445	T13439	amod	untranslated,region
R4151	T13446	T13439	punct	(,region
R4152	T13447	T13439	appos	UTR,region
R4153	T13448	T13439	punct	),region
R4154	T13449	T13433	punct	),CDS
R4155	T13450	T13427	punct	", ",sequenced
R4156	T13451	T13427	advcl	representing,sequenced
R4157	T13452	T13453	nummod	"25,083",acids
R4158	T13453	T13451	dobj	acids,representing
R4159	T13454	T13453	compound	amino,acids
R4160	T13455	T13427	punct	.,sequenced
R4161	T13457	T13458	nsubj	Comparison,identified
R4162	T13459	T13457	prep	with,Comparison
R4163	T13460	T13461	det	the,assembly
R4164	T13461	T13459	pobj	assembly,with
R4165	T13462	T13461	amod	public,assembly
R4166	T13463	T13461	compound	B6,assembly
R4167	T13464	T13465	punct	(,Build
R4168	T13465	T13457	parataxis	Build,Comparison
R4169	T13466	T13467	npadvmod	May,University
R4170	T13467	T13465	dep	University,Build
R4171	T13468	T13466	npadvmod	2004,May
R4172	T13469	T13467	prep	of,University
R4173	T13470	T13469	pobj	California,of
R4174	T13471	T13467	punct	", ",University
R4175	T13472	T13473	compound	Santa,Cruz
R4176	T13473	T13467	npadvmod	Cruz,University
R4177	T13474	T13475	punct	(,28
R4178	T13475	T13467	parataxis	28,University
R4179	T13476	T13475	dep	UCSC,28
R4180	T13477	T13475	punct	[,28
R4181	T13478	T13475	punct	],28
R4182	T13479	T13475	punct	),28
R4183	T13480	T13481	compound	mm5,assembly
R4184	T13481	T13465	dep	assembly,Build
R4185	T13482	T13481	compound	genome,assembly
R4186	T13483	T13465	punct	", ",Build
R4187	T13484	T13485	compound	National,Center
R4188	T13485	T13465	dep	Center,Build
R4189	T13486	T13485	prep	for,Center
R4190	T13487	T13488	compound	Biotechnology,Information
R4191	T13488	T13486	pobj	Information,for
R4192	T13489	T13485	punct	(,Center
R4193	T13490	T13485	appos	NCBI,Center
R4194	T13491	T13485	punct	),Center
R4195	T13492	T13465	nummod	33,Build
R4196	T13493	T13465	punct	),Build
R4197	T13494	T13495	nummod	307,polymorphisms
R4198	T13495	T13458	dobj	polymorphisms,identified
R4199	T13496	T13495	prep	between,polymorphisms
R4200	T13497	T13496	pobj	CAST,between
R4201	T13498	T13497	cc	and,CAST
R4202	T13499	T13497	conj	B6,CAST
R4203	T13500	T13458	punct	.,identified
R4204	T13502	T13503	prep	Of,were
R4205	T13504	T13502	pobj	these,Of
R4206	T13505	T13503	punct	", ",were
R4207	T13506	T13503	nsubj	295,were
R4208	T13507	T13508	amod	single,polymorphisms
R4209	T13508	T13503	attr	polymorphisms,were
R4210	T13509	T13508	compound	nucleotide,polymorphisms
R4211	T13510	T13508	punct	(,polymorphisms
R4212	T13511	T13508	appos	SNP,polymorphisms
R4213	T13512	T13503	punct	),were
R4214	T13513	T13503	cc	and,were
R4215	T13514	T13515	nsubj	12,were
R4216	T13515	T13503	conj	were,were
R4217	T13516	T13515	attr	insertions,were
R4218	T13517	T13516	cc	or,insertions
R4219	T13518	T13516	conj	deletions,insertions
R4220	T13519	T13516	prep	in,insertions
R4221	T13520	T13519	pobj	CAST,in
R4222	T13521	T13522	punct	(,File
R4223	T13522	T13503	parataxis	File,were
R4224	T13523	T13522	amod	Additional,File
R4225	T13524	T13522	nummod	4,File
R4226	T13525	T13522	punct	),File
R4227	T13526	T13503	punct	.,were
R4228	T13528	T13529	predet	All,insertions
R4229	T13529	T13531	nsubjpass	insertions,located
R4230	T13530	T13529	nummod	12,insertions
R4231	T13532	T13529	cc	or,insertions
R4232	T13533	T13529	conj	deletions,insertions
R4233	T13534	T13531	auxpass	were,located
R4234	T13535	T13531	prep	within,located
R4235	T13536	T13537	nummod	5,UTRs
R4236	T13537	T13535	pobj	UTRs,within
R4237	T13538	T13536	punct	',5
R4238	T13539	T13536	cc	and,5
R4239	T13540	T13536	conj	3,5
R4240	T13541	T13540	punct	',3
R4241	T13542	T13531	punct	.,located
R4242	T13544	T13545	compound	Fifty,six
R4243	T13545	T13547	nummod	six,SNP
R4244	T13546	T13545	punct	-,six
R4245	T13547	T13549	nsubjpass	SNP,identified
R4246	T13548	T13547	amod	nonsynonomous,SNP
R4247	T13550	T13547	punct	(,SNP
R4248	T13551	T13547	appos	nsSNP,SNP
R4249	T13552	T13549	punct	),identified
R4250	T13553	T13549	auxpass	were,identified
R4251	T13554	T13549	prep	in,identified
R4252	T13555	T13556	nummod	14,genes
R4253	T13556	T13554	pobj	genes,in
R4254	T13557	T13556	amod	different,genes
R4255	T13558	T13559	punct	(,File
R4256	T13559	T13549	parataxis	File,identified
R4257	T13560	T13559	amod	Additional,File
R4258	T13561	T13559	nummod	4,File
R4259	T13562	T13559	punct	),File
R4260	T13563	T13549	punct	.,identified
R4261	T13565	T13566	nsubj	PolyPhen,are
R4262	T13567	T13568	punct	[,29
R4263	T13568	T13565	parataxis	29,PolyPhen
R4264	T13569	T13568	punct	],29
R4265	T13570	T13565	cc	and,PolyPhen
R4266	T13571	T13565	conj	SIFT,PolyPhen
R4267	T13572	T13573	punct	[,30
R4268	T13573	T13571	parataxis	30,SIFT
R4269	T13574	T13573	punct	],30
R4270	T13575	T13576	compound	software,programs
R4271	T13576	T13566	attr	programs,are
R4272	T13577	T13576	acl	designed,programs
R4273	T13578	T13579	aux	to,identify
R4274	T13579	T13577	advcl	identify,designed
R4275	T13580	T13579	dobj	nsSNP,identify
R4276	T13581	T13582	dep	which,alter
R4277	T13582	T13580	relcl	alter,nsSNP
R4278	T13583	T13582	advmod	potentially,alter
R4279	T13584	T13585	compound	protein,function
R4280	T13585	T13582	dobj	function,alter
R4281	T13586	T13579	prep	by,identify
R4282	T13587	T13586	pcomp	evaluating,by
R4283	T13588	T13589	amod	evolutionary,conservation
R4284	T13589	T13587	dobj	conservation,evaluating
R4285	T13590	T13587	prep	at,evaluating
R4286	T13591	T13592	amod	specific,residues
R4287	T13592	T13590	pobj	residues,at
R4288	T13593	T13594	compound	amino,acid
R4289	T13594	T13592	compound	acid,residues
R4290	T13595	T13587	advcl	using,evaluating
R4291	T13596	T13597	det	a,alignment
R4292	T13597	T13595	dobj	alignment,using
R4293	T13598	T13599	amod	multiple,sequence
R4294	T13599	T13597	compound	sequence,alignment
R4295	T13600	T13597	prep	of,alignment
R4296	T13601	T13602	compound	protein,sequences
R4297	T13602	T13600	pobj	sequences,of
R4298	T13603	T13602	amod	homologous,sequences
R4299	T13604	T13603	prep	to,homologous
R4300	T13605	T13606	det	the,query
R4301	T13606	T13604	pobj	query,to
R4302	T13607	T13566	punct	.,are
R4303	T13609	T13610	advmod	When,applied
R4304	T13610	T13611	advcl	applied,predicted
R4305	T13612	T13610	prep	to,applied
R4306	T13613	T13614	poss	our,set
R4307	T13614	T13612	pobj	set,to
R4308	T13615	T13614	compound	data,set
R4309	T13616	T13611	nsubj	PolyPhen,predicted
R4310	T13617	T13616	punct	", ",PolyPhen
R4311	T13618	T13616	conj	SIFT,PolyPhen
R4312	T13619	T13618	cc	or,SIFT
R4313	T13620	T13621	det	both,programs
R4314	T13621	T13618	conj	programs,SIFT
R4315	T13622	T13623	mark	that,alter
R4316	T13623	T13611	ccomp	alter,predicted
R4317	T13624	T13625	quantmod	15,56
R4318	T13625	T13628	nummod	56,nsSNP
R4319	T13626	T13625	quantmod	of,56
R4320	T13627	T13625	quantmod	the,56
R4321	T13628	T13623	nsubj	nsSNP,alter
R4322	T13629	T13628	prep	in,nsSNP
R4323	T13630	T13631	nummod	9,genes
R4324	T13631	T13629	pobj	genes,in
R4325	T13632	T13631	amod	different,genes
R4326	T13633	T13623	aux	would,alter
R4327	T13634	T13623	advmod	possibly,alter
R4328	T13635	T13636	compound	protein,function
R4329	T13636	T13623	dobj	function,alter
R4330	T13637	T13638	punct	(,Table
R4331	T13638	T13611	parataxis	Table,predicted
R4332	T13639	T13638	nummod	7,Table
R4333	T13640	T13638	punct	),Table
R4334	T13641	T13611	punct	.,predicted
R4337	T17718	T17719	npadvmod	Speed,congenic
R4338	T17719	T17720	amod	congenic,strains
R4339	T17720	T17721	nsubj	strains,provide
R4340	T17722	T17723	det	a,approach
R4341	T17723	T17721	dobj	approach,provide
R4342	T17724	T17723	amod	powerful,approach
R4343	T17725	T17726	aux	to,confirm
R4344	T17726	T17723	acl	confirm,approach
R4345	T17727	T17726	cc	and,confirm
R4346	T17728	T17729	advmod	physically,confine
R4347	T17729	T17726	conj	confine,confirm
R4348	T17730	T17729	dobj	QTL,confine
R4349	T17731	T17729	prep	within,confine
R4350	T17732	T17731	pobj	intervals,within
R4351	T17733	T17732	acl	defined,intervals
R4352	T17734	T17733	prep	by,defined
R4353	T17735	T17736	amod	molecular,markers
R4354	T17736	T17734	pobj	markers,by
R4355	T17737	T17721	punct	.,provide
R4356	T17739	T17740	prep	In,isolated
R4357	T17741	T17742	det	the,study
R4358	T17742	T17739	pobj	study,In
R4359	T17743	T17742	amod	current,study
R4360	T17744	T17740	punct	", ",isolated
R4361	T17745	T17746	advmod	approximately,20
R4362	T17746	T17747	nummod	20,%
R4363	T17747	T17740	nsubjpass	%,isolated
R4364	T17748	T17747	prep	of,%
R4365	T17749	T17750	det	the,genome
R4366	T17750	T17748	pobj	genome,of
R4367	T17751	T17750	compound	CAST,genome
R4368	T17752	T17750	acl	harboring,genome
R4369	T17753	T17754	advmod	all,QTL
R4370	T17754	T17752	dobj	QTL,harboring
R4371	T17755	T17756	advmod	previously,detected
R4372	T17756	T17754	amod	detected,QTL
R4373	T17757	T17758	nmod	growth,composition
R4374	T17758	T17754	compound	composition,QTL
R4375	T17759	T17757	cc	and,growth
R4376	T17760	T17757	conj	carcass,growth
R4377	T17761	T17740	auxpass	was,isolated
R4378	T17762	T17740	prep	on,isolated
R4379	T17763	T17764	det	an,background
R4380	T17764	T17762	pobj	background,on
R4381	T17765	T17764	nmod	HG,background
R4382	T17766	T17765	cc	or,HG
R4383	T17767	T17765	conj	B6,HG
R4384	T17768	T17740	prep	through,isolated
R4385	T17769	T17770	det	the,development
R4386	T17770	T17768	pobj	development,through
R4387	T17771	T17770	prep	of,development
R4388	T17772	T17773	nummod	14,strains
R4389	T17773	T17771	pobj	strains,of
R4390	T17774	T17775	npadvmod	speed,congenic
R4391	T17775	T17773	amod	congenic,strains
R4392	T17776	T17740	punct	.,isolated
R4393	T17778	T17779	nummod	Two,panels
R4394	T17779	T17783	nsubjpass	panels,developed
R4395	T17780	T17779	amod	distinct,panels
R4396	T17781	T17782	npadvmod	speed,congenic
R4397	T17782	T17779	amod	congenic,panels
R4398	T17783	T17785	ccomp	developed,provided
R4399	T17784	T17783	auxpass	were,developed
R4400	T17786	T17785	punct	", ",provided
R4401	T17787	T17788	det	the,first
R4402	T17788	T17785	nsubj	first,provided
R4403	T17789	T17790	det	a,isolation
R4404	T17790	T17785	dobj	isolation,provided
R4405	T17791	T17790	amod	comprehensive,isolation
R4406	T17792	T17790	prep	of,isolation
R4407	T17793	T17794	det	all,QTL
R4408	T17794	T17792	pobj	QTL,of
R4409	T17795	T17794	compound	MMU2,QTL
R4410	T17796	T17794	prep	between,QTL
R4411	T17797	T17798	det	the,strains
R4412	T17798	T17796	pobj	strains,between
R4413	T17799	T17798	nmod	B6,strains
R4414	T17800	T17799	punct	", ",B6
R4415	T17801	T17799	conj	HG,B6
R4416	T17802	T17801	cc	and,HG
R4417	T17803	T17801	conj	CAST,HG
R4418	T17804	T17785	cc	and,provided
R4419	T17805	T17806	det	the,second
R4420	T17806	T17807	nsubj	second,targeted
R4421	T17807	T17785	conj	targeted,provided
R4422	T17808	T17809	det	all,QTL
R4423	T17809	T17807	dobj	QTL,targeted
R4424	T17810	T17809	prep	outside,QTL
R4425	T17811	T17810	prep	of,outside
R4426	T17812	T17811	pobj	MMU2,of
R4427	T17813	T17785	punct	.,provided
R4428	T17815	T17816	det	Each,strain
R4429	T17816	T17819	nsubj	strain,exhibited
R4430	T17817	T17818	advmod	successfully,characterized
R4431	T17818	T17816	amod	characterized,strain
R4432	T17820	T17821	amod	phenotypic,differences
R4433	T17821	T17819	dobj	differences,exhibited
R4434	T17822	T17819	advcl	relative,exhibited
R4435	T17823	T17822	prep	to,relative
R4436	T17824	T17825	compound	control,mice
R4437	T17825	T17823	pobj	mice,to
R4438	T17826	T17819	punct	.,exhibited
R4439	T17828	T17829	det	These,strains
R4440	T17829	T17830	nsubj	strains,represent
R4441	T17831	T17832	amod	important,resources
R4442	T17832	T17830	dobj	resources,represent
R4443	T17833	T17830	cc	and,represent
R4444	T17834	T17830	conj	provide,represent
R4445	T17835	T17836	det	the,resource
R4446	T17836	T17834	dobj	resource,provide
R4447	T17837	T17836	amod	genetic,resource
R4448	T17838	T17839	aux	to,clone
R4449	T17839	T17836	advcl	clone,resource
R4450	T17840	T17839	advmod	positionally,clone
R4451	T17841	T17842	amod	numerous,genes
R4452	T17842	T17839	dobj	genes,clone
R4453	T17843	T17844	amod	quantitative,trait
R4454	T18103	T18100	pobj	variation,due
R4455	T17844	T17842	compound	trait,genes
R4456	T18104	T18103	prep	within,variation
R4457	T17845	T17830	punct	.,represent
R4458	T18105	T18106	det	each,region
R4459	T18106	T18104	pobj	region,within
R4460	T17847	T17848	nummod	One,criticism
R4461	T18107	T18106	compound	donor,region
R4462	T18108	T18076	punct	.,screened
R4463	T17848	T17849	nsubj	criticism,is
R4464	T18110	T18111	mark	Although,put
R4465	T18111	T18115	advcl	put,confound
R4466	T17850	T17848	prep	of,criticism
R4467	T18112	T18113	amod	great,effort
R4468	T18113	T18111	nsubjpass	effort,put
R4469	T18114	T18111	auxpass	was,put
R4470	T17851	T17852	det	the,approach
R4471	T18116	T18111	prt	forth,put
R4472	T18117	T18118	aux	to,eliminate
R4473	T17852	T17850	pobj	approach,of
R4474	T18118	T18111	advcl	eliminate,put
R4475	T18119	T18120	amod	non-donor,region
R4476	T17853	T17854	npadvmod	speed,congenic
R4477	T18120	T18121	nmod	region,effects
R4478	T18121	T18118	dobj	effects,eliminate
R4479	T18122	T18121	amod	direct,effects
R4480	T17854	T17852	amod	congenic,approach
R4481	T18123	T18121	amod	genetic,effects
R4482	T18124	T18115	punct	", ",confound
R4483	T18125	T18126	amod	other,factors
R4484	T17855	T17856	det	the,potential
R4485	T18126	T18115	nsubj	factors,confound
R4486	T17856	T17849	attr	potential,is
R4487	T17857	T17858	mark	for,reside
R4488	T17858	T17856	advcl	reside,potential
R4489	T17859	T17858	nsubj	QTL,reside
R4490	T18127	T18128	amod	such,as
R4491	T18128	T18126	prep	as,factors
R4492	T18129	T18130	amod	maternal,genotype
R4493	T18130	T18128	pobj	genotype,as
R4494	T17860	T17858	aux	to,reside
R4495	T18131	T18132	punct	(,differed
R4496	T18132	T18130	parataxis	differed,genotype
R4497	T18133	T18134	amod	maternal,genotype
R4498	T17861	T17858	prep	among,reside
R4499	T18134	T18132	nsubj	genotype,differed
R4500	T17862	T17863	amod	unwanted,alleles
R4501	T18135	T18134	prep	for,genotype
R4502	T18136	T18137	det	each,congenic
R4503	T18137	T18135	pobj	congenic,for
R4504	T18138	T18134	cc	versus,genotype
R4505	T18139	T18140	compound	control,dams
R4506	T17863	T17861	pobj	alleles,among
R4507	T18140	T18134	conj	dams,genotype
R4508	T18141	T18132	punct	),differed
R4509	T18142	T18126	cc	and,factors
R4510	T18143	T18144	amod	environmental,effects
R4511	T18144	T18126	conj	effects,factors
R4512	T18145	T18115	aux	could,confound
R4513	T18146	T18147	poss	our,results
R4514	T18147	T18115	dobj	results,confound
R4515	T18148	T18115	punct	.,confound
R4516	T17864	T17863	compound	donor,alleles
R4517	T18150	T18151	amod	Maternal,genotype
R4518	T18151	T18152	compound	genotype,effects
R4519	T17865	T17866	neg	not,eliminated
R4520	T18152	T18153	nsubjpass	effects,observed
R4521	T18154	T18152	prep	on,effects
R4522	T17866	T17863	acl	eliminated,alleles
R4523	T18155	T18154	pobj	growth,on
R4524	T18156	T18155	cc	and,growth
R4525	T17867	T17866	prep	during,eliminated
R4526	T18157	T18155	conj	obesity,growth
R4527	T18158	T18153	aux	have,observed
R4528	T18159	T18153	auxpass	been,observed
R4529	T17868	T17867	pobj	backcrossing,during
R4530	T18160	T18153	prep	in,observed
R4531	T18161	T18162	det	a,number
R4532	T18162	T18160	pobj	number,in
R4533	T17869	T17849	punct	.,is
R4534	T18163	T18162	prep	of,number
R4535	T18164	T18165	compound	mouse,crosses
R4536	T17871	T17872	prep	In,be
R4537	T18165	T18163	pobj	crosses,of
R4538	T18166	T18167	punct	[,8
R4539	T18167	T18153	parataxis	8,observed
R4540	T18168	T18167	punct	",",8
R4541	T17873	T17874	det	this,case
R4542	T18169	T18167	appos	32,8
R4543	T18170	T18171	punct	-,35
R4544	T18171	T18169	prep	35,32
R4545	T18172	T18167	punct	],8
R4546	T18173	T18153	cc	and,observed
R4547	T18174	T18175	poss	their,existence
R4548	T18175	T18176	nsubjpass	existence,discounted
R4549	T17874	T17871	pobj	case,In
R4550	T18176	T18153	conj	discounted,observed
R4551	T18177	T18175	prep	in,existence
R4552	T18178	T18179	det	the,cross
R4553	T17875	T17872	nsubj	differences,be
R4554	T18179	T18177	pobj	cross,in
R4555	T18180	T18179	amod	current,cross
R4556	T18181	T18176	aux	can,discounted
R4557	T17876	T17875	prep	between,differences
R4558	T18182	T18176	neg	not,discounted
R4559	T18183	T18176	auxpass	be,discounted
R4560	T18184	T18176	punct	.,discounted
R4561	T17877	T17878	det	the,strains
R4562	T18186	T18187	advmod	However,provide
R4563	T17878	T17876	pobj	strains,between
R4564	T18188	T18187	punct	", ",provide
R4565	T18189	T18190	poss	our,congenics
R4566	T17879	T17878	amod	congenic,strains
R4567	T18190	T18187	nsubj	congenics,provide
R4568	T18191	T18192	det	the,resource
R4569	T17880	T17879	cc	and,congenic
R4570	T18192	T18187	dobj	resource,provide
R4571	T18193	T18192	amod	ideal,resource
R4572	T18194	T18192	nmod	foundation,resource
R4573	T17881	T17879	conj	control,congenic
R4574	T18195	T18192	amod	genomic,resource
R4575	T18196	T18197	aux	to,test
R4576	T18197	T18192	advcl	test,resource
R4577	T17882	T17872	aux	would,be
R4578	T18198	T18197	prep	for,test
R4579	T18199	T18200	det	the,influence
R4580	T18200	T18198	pobj	influence,for
R4581	T17883	T17872	prep	due,be
R4582	T18201	T18200	prep	of,influence
R4583	T18202	T18201	pobj	any,of
R4584	T18203	T18202	prep	of,any
R4585	T17884	T17883	prep	in,due
R4586	T18204	T18205	det	these,effects
R4587	T18205	T18203	pobj	effects,of
R4588	T17885	T17884	pobj	part,in
R4589	T17886	T17885	cc	or,part
R4590	T18206	T18205	amod	possible,effects
R4591	T18207	T18187	punct	.,provide
R4592	T17887	T17885	conj	whole,part
R4593	T18209	T18210	amod	Future,experiments
R4594	T18210	T18213	nsubjpass	experiments,designed
R4595	T18211	T18212	amod	fine,mapping
R4596	T17888	T17883	pcomp	to,due
R4597	T18212	T18210	compound	mapping,experiments
R4598	T17889	T17890	det	these,alleles
R4599	T17890	T17883	pobj	alleles,due
R4600	T17891	T17890	amod	contaminating,alleles
R4601	T17892	T17872	punct	.,be
R4602	T17894	T17895	nsubj	We,took
R4603	T18214	T18213	aux	can,designed
R4604	T18215	T18213	auxpass	be,designed
R4605	T18216	T18217	aux	to,randomize
R4606	T17896	T17897	amod	several,precautions
R4607	T18217	T18213	advcl	randomize,designed
R4608	T18218	T18219	det	the,influences
R4609	T17897	T17895	dobj	precautions,took
R4610	T18219	T18217	dobj	influences,randomize
R4611	T18220	T18219	prep	of,influences
R4612	T18221	T18222	det	any,alleles
R4613	T17898	T17899	aux	to,reduce
R4614	T18222	T18220	pobj	alleles,of
R4615	T18223	T18222	amod	contaminating,alleles
R4616	T17899	T17895	advcl	reduce,took
R4617	T18224	T18222	compound	donor,alleles
R4618	T18225	T18222	cc	and,alleles
R4619	T18226	T18227	amod	environmental,differences
R4620	T17900	T17901	det	the,probability
R4621	T18227	T18222	conj	differences,alleles
R4622	T18228	T18217	punct	", ",randomize
R4623	T18229	T18230	advmod	as,as
R4624	T17901	T17899	dobj	probability,reduce
R4625	T18230	T18217	cc	as,randomize
R4626	T18231	T18230	advmod	well,as
R4627	T18232	T18217	conj	test,randomize
R4628	T17902	T17901	prep	of,probability
R4629	T18233	T18232	prep	for,test
R4630	T18234	T18235	amod	maternal,genotype
R4631	T17903	T17904	det	this,occurrence
R4632	T18235	T18236	compound	genotype,effects
R4633	T18236	T18233	pobj	effects,for
R4634	T18237	T18213	punct	.,designed
R4635	T17904	T17902	pobj	occurrence,of
R4636	T18239	T18240	nsubj	MMU2,is
R4637	T17905	T17895	punct	.,took
R4638	T18241	T18242	det	a,hotspot
R4639	T18242	T18240	attr	hotspot,is
R4640	T17907	T17908	advmod	First,developed
R4641	T18243	T18242	prep	for,hotspot
R4642	T18244	T18245	nmod	growth,QTL
R4643	T18245	T18243	pobj	QTL,for
R4644	T18246	T18244	cc	and,growth
R4645	T17909	T17908	punct	", ",developed
R4646	T18247	T18244	conj	obesity,growth
R4647	T18248	T18240	punct	.,is
R4648	T18250	T18251	quantmod	Over,30
R4649	T18251	T18252	nummod	30,QTL
R4650	T18252	T18253	nsubjpass	QTL,identified
R4651	T17910	T17911	poss	our,strains
R4652	T18254	T18253	aux	have,identified
R4653	T18255	T18253	auxpass	been,identified
R4654	T17911	T17908	nsubjpass	strains,developed
R4655	T18256	T18253	prep	in,identified
R4656	T18257	T18258	amod	various,experiments
R4657	T18258	T18256	pobj	experiments,in
R4658	T17912	T17911	compound	control,strains
R4659	T18259	T18260	punct	[,2
R4660	T18260	T18253	parataxis	2,identified
R4661	T17913	T17908	auxpass	were,developed
R4662	T18261	T18260	nummod	1,2
R4663	T18262	T18260	punct	",",2
R4664	T17914	T17908	prep	from,developed
R4665	T18263	T18260	punct	],2
R4666	T18264	T18253	punct	.,identified
R4667	T17915	T17914	pobj	mice,from
R4668	T18266	T18267	amod	Several,QTL
R4669	T18267	T18273	nsubjpass	QTL,isolated
R4670	T18268	T18269	advmod	previously,reported
R4671	T17916	T17915	acl	undergoing,mice
R4672	T18269	T18267	amod	reported,QTL
R4673	T18270	T18269	cc	or,reported
R4674	T18271	T18269	conj	novel,reported
R4675	T17917	T17918	det	the,selection
R4676	T18272	T18267	compound	MMU2,QTL
R4677	T18274	T18273	aux	have,isolated
R4678	T17918	T17916	dobj	selection,undergoing
R4679	T18275	T18273	auxpass	been,isolated
R4680	T18276	T18273	cc	and,isolated
R4681	T17919	T17918	amod	same,selection
R4682	T18277	T18273	conj	characterized,isolated
R4683	T18278	T18277	advcl	using,characterized
R4684	T18279	T18280	amod	congenic,strains
R4685	T17920	T17918	prep	as,selection
R4686	T18280	T18278	dobj	strains,using
R4687	T18281	T18282	punct	[,7
R4688	T18282	T18277	parataxis	7,characterized
R4689	T17921	T17920	pobj	all,as
R4690	T18283	T18282	punct	",",7
R4691	T18284	T18282	appos	9,7
R4692	T18285	T18286	punct	-,11
R4693	T17922	T17921	prep	of,all
R4694	T18286	T18284	prep	11,9
R4695	T18287	T18282	punct	",",7
R4696	T18288	T18282	appos	36,7
R4697	T17923	T17924	det	the,congenics
R4698	T18289	T18282	punct	],7
R4699	T18290	T18273	punct	.,isolated
R4700	T18292	T18293	poss	Our,findings
R4701	T18293	T18294	nsubj	findings,are
R4702	T17924	T17922	pobj	congenics,of
R4703	T18295	T18296	neg	no,different
R4704	T18296	T18294	acomp	different,are
R4705	T17925	T17924	amod	other,congenics
R4706	T18297	T18296	cc	and,different
R4707	T18298	T18296	conj	indicate,different
R4708	T18299	T18300	mark	that,is
R4709	T17926	T17908	punct	.,developed
R4710	T18300	T18298	ccomp	is,indicate
R4711	T18301	T18300	nsubj	MMU2,is
R4712	T17928	T17929	advmod	Therefore,is
R4713	T18302	T18303	advmod	highly,complex
R4714	T17930	T17929	punct	", ",is
R4715	T17931	T17929	nsubj	it,is
R4716	T17932	T17929	acomp	possible,is
R4717	T18303	T18300	acomp	complex,is
R4718	T17933	T17934	mark	that,shared
R4719	T18304	T18300	prep	with,is
R4720	T18305	T18304	pobj	regards,with
R4721	T17934	T17929	ccomp	shared,is
R4722	T18306	T18305	prep	to,regards
R4723	T18307	T18308	nsubj	genes,affecting
R4724	T18308	T18306	pcomp	affecting,to
R4725	T17935	T17936	det	any,QTL
R4726	T18309	T18308	dobj	growth,affecting
R4727	T18310	T18309	cc	and,growth
R4728	T18311	T18309	conj	obesity,growth
R4729	T17936	T17934	nsubjpass	QTL,shared
R4730	T17937	T17936	amod	unwanted,QTL
R4731	T18312	T18294	punct	.,are
R4732	T17938	T17936	cc	or,QTL
R4733	T18314	T18315	det	The,nature
R4734	T18315	T18317	nsubj	nature,allowed
R4735	T17939	T17936	conj	mutations,QTL
R4736	T18316	T18315	amod	overlapping,nature
R4737	T17940	T17939	acl	arising,mutations
R4738	T18318	T18315	prep	of,nature
R4739	T18319	T18320	poss	our,strains
R4740	T18320	T18318	pobj	strains,of
R4741	T17941	T17940	prep	during,arising
R4742	T18321	T18320	compound	MMU2,strains
R4743	T18322	T18323	nsubj	us,parse
R4744	T17942	T17943	amod	congenic,construction
R4745	T18323	T18317	ccomp	parse,allowed
R4746	T18324	T18323	aux	to,parse
R4747	T17943	T17941	pobj	construction,during
R4748	T18325	T18326	det	the,chromosome
R4749	T18326	T18323	dobj	chromosome,parse
R4750	T18327	T18323	prep	into,parse
R4751	T18328	T18329	nummod	five,regions
R4752	T18329	T18327	pobj	regions,into
R4753	T17944	T17934	auxpass	are,shared
R4754	T18330	T18329	punct	(,regions
R4755	T18331	T18332	nmod	Regions,I
R4756	T18332	T18329	appos	I,regions
R4757	T17945	T17934	prep	between,shared
R4758	T18333	T18334	punct	–,V
R4759	T18334	T18332	prep	V,I
R4760	T18335	T18317	punct	),allowed
R4761	T18336	T18337	punct	(,Figure
R4762	T17946	T17947	det	all,strains
R4763	T18337	T18317	parataxis	Figure,allowed
R4764	T18338	T18337	nummod	2,Figure
R4765	T17947	T17945	pobj	strains,between
R4766	T17948	T17929	punct	.,is
R4767	T17950	T17951	advmod	More,importantly
R4768	T17951	T17952	advmod	importantly,have
R4769	T17953	T17952	punct	", ",have
R4770	T17954	T17952	nsubj	we,have
R4771	T18339	T18337	punct	),Figure
R4772	T17955	T17952	dobj	knowledge,have
R4773	T18340	T18317	punct	.,allowed
R4774	T18342	T18343	det	The,data
R4775	T18343	T18344	nsubj	data,support
R4776	T18345	T18346	det	the,presence
R4777	T18346	T18344	dobj	presence,support
R4778	T18347	T18346	prep	of,presence
R4779	T18348	T18349	advmod	at,one
R4780	T17956	T17955	prep	of,knowledge
R4781	T18349	T18351	nummod	one,QTL
R4782	T18350	T18349	advmod	least,one
R4783	T18351	T18347	pobj	QTL,of
R4784	T18352	T18346	prep	in,presence
R4785	T17957	T17958	det	all,QTL
R4786	T18353	T18352	pobj	each,in
R4787	T18354	T18353	prep	of,each
R4788	T18355	T18356	det	the,regions
R4789	T17958	T17956	pobj	QTL,of
R4790	T18356	T18354	pobj	regions,of
R4791	T18357	T18356	nummod	five,regions
R4792	T17959	T17958	amod	large,QTL
R4793	T18358	T18359	punct	(,Figure
R4794	T18359	T18344	parataxis	Figure,support
R4795	T18360	T18359	nummod	2,Figure
R4796	T17960	T17961	advmod	previously,detected
R4797	T18361	T18359	punct	),Figure
R4798	T18362	T18344	punct	.,support
R4799	T17961	T17958	amod	detected,QTL
R4800	T18364	T18365	nsubj	Each,impact
R4801	T17962	T17958	nmod	growth,QTL
R4802	T18366	T18364	prep	of,Each
R4803	T18367	T18368	det	the,five
R4804	T18368	T18366	pobj	five,of
R4805	T18369	T18365	advmod	pleiotropically,impact
R4806	T18370	T18371	preconj	both,growth
R4807	T17963	T17962	cc	and,growth
R4808	T18371	T18365	dobj	growth,impact
R4809	T18372	T18371	cc	and,growth
R4810	T18373	T18371	conj	obesity,growth
R4811	T17964	T17962	conj	obesity,growth
R4812	T18374	T18365	punct	", ",impact
R4813	T18375	T18376	mark	although,to
R4814	T17965	T17958	prep	in,QTL
R4815	T18376	T18365	advcl	to,impact
R4816	T18377	T18378	amod	varying,degrees
R4817	T18378	T18376	pobj	degrees,to
R4818	T17966	T17967	det	the,cross
R4819	T18379	T18365	punct	.,impact
R4820	T17967	T17965	pobj	cross,in
R4821	T18381	T18382	prep	In,adds
R4822	T18383	T18381	pobj	addition,In
R4823	T17968	T17967	amod	current,cross
R4824	T18384	T18383	prep	to,addition
R4825	T18385	T18386	det	the,number
R4826	T17969	T17970	punct	[,24
R4827	T18386	T18384	pobj	number,to
R4828	T18387	T18386	amod	large,number
R4829	T18388	T18386	prep	of,number
R4830	T17970	T17952	parataxis	24,have
R4831	T18389	T18390	compound	MMU2,QTL
R4832	T18390	T18388	pobj	QTL,of
R4833	T18391	T18382	punct	", ",adds
R4834	T17971	T17970	punct	],24
R4835	T17972	T17952	punct	.,have
R4836	T17974	T17975	advcl	Using,increased
R4837	T17976	T17977	det	this,information
R4838	T18392	T18393	det	the,presence
R4839	T17977	T17974	dobj	information,Using
R4840	T18393	T18382	nsubj	presence,adds
R4841	T18394	T18393	prep	of,presence
R4842	T17978	T17975	nsubj	we,increased
R4843	T18395	T18394	pobj	hg,of
R4844	T18396	T18382	dobj	complexity,adds
R4845	T17979	T17980	det	the,density
R4846	T18397	T18382	prep	by,adds
R4847	T18398	T18397	preconj	either,by
R4848	T18399	T18397	conj	eliciting,by
R4849	T17980	T17975	dobj	density,increased
R4850	T18400	T18399	dobj	interactions,eliciting
R4851	T18401	T18400	prep	with,interactions
R4852	T17981	T17980	prep	of,density
R4853	T18402	T18403	det	the,QTL
R4854	T18403	T18401	pobj	QTL,with
R4855	T18404	T18403	amod	same,QTL
R4856	T18405	T18397	cc	or,by
R4857	T18406	T18397	conj	by,by
R4858	T17982	T17981	pobj	markers,of
R4859	T18407	T18406	pcomp	inducing,by
R4860	T18408	T18409	det	the,expression
R4861	T18409	T18407	dobj	expression,inducing
R4862	T17983	T17980	prep	in,density
R4863	T18410	T18409	prep	of,expression
R4864	T18411	T18412	amod	novel,QTL
R4865	T18412	T18410	pobj	QTL,of
R4866	T17984	T17985	det	each,region
R4867	T18413	T18382	punct	.,adds
R4868	T17985	T17983	pobj	region,in
R4869	T18415	T18416	det	The,region
R4870	T18416	T18419	nsubj	region,contains
R4871	T18417	T18416	nmod	2P,region
R4872	T17986	T17985	compound	QTL,region
R4873	T17987	T17988	punct	(,Table
R4874	T18418	T18416	amod	unique,region
R4875	T17988	T17975	parataxis	Table,increased
R4876	T18420	T18416	punct	(,region
R4877	T17989	T17990	nmod	MMU,1
R4878	T18421	T18416	appos	Region,region
R4879	T18422	T18421	nummod	I,Region
R4880	T17990	T17988	dep	1,Table
R4881	T18423	T18419	punct	),contains
R4882	T18424	T18425	det	an,modifier
R4883	T18425	T18419	dobj	modifier,contains
R4884	T17991	T17990	punct	", ",1
R4885	T18426	T18425	compound	hg,modifier
R4886	T18427	T18425	prep	with,modifier
R4887	T17992	T17990	conj	2,1
R4888	T18428	T18429	amod	large,effects
R4889	T18429	T18427	pobj	effects,with
R4890	T17993	T17992	punct	", ",2
R4891	T18430	T18429	prep	on,effects
R4892	T18431	T18430	pobj	growth,on
R4893	T17994	T17992	conj	5,2
R4894	T18432	T18429	cc	and,effects
R4895	T18433	T18434	amod	smaller,effects
R4896	T17995	T17994	punct	", ",5
R4897	T18434	T18429	conj	effects,effects
R4898	T18435	T18434	prep	on,effects
R4899	T18436	T18435	pobj	obesity,on
R4900	T17996	T17994	conj	8,5
R4901	T18437	T18438	punct	(,Table
R4902	T18438	T18419	parataxis	Table,contains
R4903	T18439	T18438	nummod	3,Table
R4904	T17997	T17996	punct	", ",8
R4905	T18440	T18438	punct	),Table
R4906	T18441	T18419	punct	.,contains
R4907	T18443	T18444	prep	In,affect
R4908	T17998	T17996	conj	9,8
R4909	T18445	T18443	pobj	contrast,In
R4910	T18446	T18444	punct	", ",affect
R4911	T18447	T18444	nsubj	interactions,affect
R4912	T17999	T17998	punct	", ",9
R4913	T18448	T18447	prep	between,interactions
R4914	T18449	T18450	compound	2PM,2M
R4915	T18450	T18452	compound	2M,QTL
R4916	T18000	T17998	conj	11,9
R4917	T18451	T18450	punct	/,2M
R4918	T18452	T18448	pobj	QTL,between
R4919	T18001	T18000	cc	and,11
R4920	T18453	T18452	cc	and,QTL
R4921	T18454	T18452	conj	hg,QTL
R4922	T18455	T18444	advmod	primarily,affect
R4923	T18002	T18000	conj	17,11
R4924	T18456	T18457	compound	fat,deposition
R4925	T18457	T18444	dobj	deposition,affect
R4926	T18003	T17988	punct	;,Table
R4927	T18458	T18459	punct	(,Table
R4928	T18459	T18444	parataxis	Table,affect
R4929	T18460	T18459	nummod	3,Table
R4930	T18004	T17988	nummod	1,Table
R4931	T18461	T18459	punct	),Table
R4932	T18462	T18444	punct	.,affect
R4933	T18005	T17988	cc	and,Table
R4934	T18464	T18465	mark	As,illustrated
R4935	T18465	T18466	advcl	illustrated,exhibits
R4936	T18006	T18007	amod	Additional,File
R4937	T18467	T18465	prep	in,illustrated
R4938	T18007	T17988	conj	File,Table
R4939	T18468	T18467	pobj	Figure,in
R4940	T18008	T18007	nummod	1,File
R4941	T18009	T17988	punct	),Table
R4942	T18010	T17975	punct	", ",increased
R4943	T18011	T17975	advcl	ensuring,increased
R4944	T18012	T18013	det	the,absence
R4945	T18469	T18468	nummod	4,Figure
R4946	T18470	T18471	det	the,region
R4947	T18471	T18466	nsubj	region,exhibits
R4948	T18013	T18011	dobj	absence,ensuring
R4949	T18472	T18471	compound	2M,region
R4950	T18473	T18471	compound	donor,region
R4951	T18474	T18475	amod	strong,effects
R4952	T18014	T18013	prep	of,absence
R4953	T18475	T18466	dobj	effects,exhibits
R4954	T18476	T18475	compound	sex,effects
R4955	T18015	T18016	compound	CAST,alleles
R4956	T18477	T18475	prep	on,effects
R4957	T18478	T18479	det	the,rate
R4958	T18016	T18014	pobj	alleles,of
R4959	T18017	T18013	prep	at,absence
R4960	T18018	T18017	pobj	each,at
R4961	T18479	T18477	pobj	rate,on
R4962	T18019	T18018	prep	of,each
R4963	T18480	T18479	prep	of,rate
R4964	T18481	T18482	compound	lipid,storage
R4965	T18482	T18480	pobj	storage,of
R4966	T18020	T18021	det	these,QTL
R4967	T18483	T18466	punct	", ",exhibits
R4968	T18484	T18466	advcl	dependent,exhibits
R4969	T18485	T18484	prep	on,dependent
R4970	T18021	T18019	pobj	QTL,of
R4971	T18486	T18485	pobj	background,on
R4972	T18487	T18466	punct	.,exhibits
R4973	T18022	T17975	punct	.,increased
R4974	T18489	T18490	prep	In,have
R4975	T18024	T18025	det	This,approach
R4976	T18491	T18492	compound	control,mice
R4977	T18492	T18489	pobj	mice,In
R4978	T18493	T18490	punct	", ",have
R4979	T18025	T18026	nsubjpass	approach,used
R4980	T18494	T18495	compound	HGC,females
R4981	T18495	T18490	nsubj	females,have
R4982	T18027	T18025	punct	", ",approach
R4983	T18496	T18497	det	a,AI
R4984	T18497	T18490	dobj	AI,have
R4985	T18498	T18497	amod	higher,AI
R4986	T18499	T18497	prep	than,AI
R4987	T18500	T18499	pobj	males,than
R4988	T18028	T18025	acl	termed,approach
R4989	T18501	T18490	punct	", ",have
R4990	T18502	T18503	mark	while,seen
R4991	T18029	T18028	punct	"""",termed
R4992	T18503	T18490	advcl	seen,have
R4993	T18504	T18505	det	the,opposite
R4994	T18505	T18503	nsubjpass	opposite,seen
R4995	T18030	T18031	compound	QTL,Marker
R4996	T18506	T18503	auxpass	is,seen
R4997	T18507	T18503	prep	in,seen
R4998	T18031	T18033	npadvmod	Marker,Assisted
R4999	T18508	T18509	compound	B6C,mice
R5000	T18509	T18507	pobj	mice,in
R5001	T18510	T18490	punct	.,have
R5002	T18032	T18031	punct	-,Marker
R5003	T18512	T18513	advmod	Interestingly,abolished
R5004	T18033	T18035	amod	Assisted,Selection
R5005	T18514	T18513	punct	", ",abolished
R5006	T18515	T18516	det	the,QTL
R5007	T18034	T18033	punct	-,Assisted
R5008	T18516	T18513	nsubj	QTL,abolished
R5009	T18517	T18516	compound	2M,QTL
R5010	T18518	T18519	compound	hg,modifier
R5011	T18519	T18516	compound	modifier,QTL
R5012	T18035	T18028	oprd	Selection,termed
R5013	T18520	T18521	det	the,dimorphism
R5014	T18521	T18513	dobj	dimorphism,abolished
R5015	T18522	T18523	npadvmod	hg,induced
R5016	T18523	T18521	amod	induced,dimorphism
R5017	T18036	T18035	compound	Counter,Selection
R5018	T18037	T18035	punct	"""",Selection
R5019	T18524	T18521	amod	sexual,dimorphism
R5020	T18038	T18035	cc	or,Selection
R5021	T18525	T18521	prep	in,dimorphism
R5022	T18526	T18525	pobj	adiposity,in
R5023	T18039	T18035	conj	QMACS,Selection
R5024	T18527	T18528	punct	(,Figure
R5025	T18528	T18513	parataxis	Figure,abolished
R5026	T18040	T18026	punct	", ",used
R5027	T18529	T18528	nummod	4,Figure
R5028	T18530	T18528	punct	),Figure
R5029	T18531	T18513	punct	.,abolished
R5030	T18533	T18534	mark	Although,provide
R5031	T18041	T18026	aux	has,used
R5032	T18534	T18537	advcl	provide,noted
R5033	T18535	T18536	det	these,results
R5034	T18042	T18026	auxpass	been,used
R5035	T18536	T18534	nsubj	results,provide
R5036	T18043	T18026	advmod	previously,used
R5037	T18538	T18534	dobj	insight,provide
R5038	T18539	T18538	prep	into,insight
R5039	T18540	T18541	det	the,nature
R5040	T18044	T18045	aux	to,characterize
R5041	T18541	T18539	pobj	nature,into
R5042	T18542	T18541	prep	of,nature
R5043	T18045	T18026	advcl	characterize,used
R5044	T18543	T18544	compound	hg,modifier
R5045	T18544	T18545	compound	modifier,QTL
R5046	T18046	T18045	dobj	QTL,characterize
R5047	T18545	T18542	pobj	QTL,of
R5048	T18546	T18537	punct	", ",noted
R5049	T18547	T18537	nsubjpass	it,noted
R5050	T18047	T18045	prep	for,characterize
R5051	T18548	T18537	aux	should,noted
R5052	T18549	T18537	auxpass	be,noted
R5053	T18048	T18049	amod	hypnotic,sensitivity
R5054	T18550	T18537	punct	", ",noted
R5055	T18551	T18552	mark	that,is
R5056	T18552	T18537	ccomp	is,noted
R5057	T18049	T18047	pobj	sensitivity,for
R5058	T18553	T18554	det	the,number
R5059	T18554	T18552	nsubj	number,is
R5060	T18555	T18554	amod	actual,number
R5061	T18556	T18554	cc	and,number
R5062	T18557	T18558	amod	precise,location
R5063	T18558	T18554	conj	location,number
R5064	T18050	T18049	prep	to,sensitivity
R5065	T18559	T18554	prep	of,number
R5066	T18560	T18559	pobj	loci,of
R5067	T18561	T18552	advmod	still,is
R5068	T18051	T18050	pobj	ethanol,to
R5069	T18562	T18552	acomp	unclear,is
R5070	T18563	T18537	punct	.,noted
R5071	T18052	T18053	punct	[,31
R5072	T18565	T18566	prep	In,captured
R5073	T18053	T18026	parataxis	31,used
R5074	T18567	T18565	pobj	addition,In
R5075	T18054	T18053	punct	],31
R5076	T18055	T18026	punct	.,used
R5077	T18057	T18058	prep	In,typed
R5078	T18059	T18060	det	that,study
R5079	T18060	T18057	pobj	study,In
R5080	T18568	T18567	prep	to,addition
R5081	T18061	T18058	punct	", ",typed
R5082	T18569	T18568	pobj	MMU2,to
R5083	T18570	T18566	punct	", ",captured
R5084	T18062	T18063	advmod	only,markers
R5085	T18571	T18572	nummod	three,congenics
R5086	T18572	T18566	nsubj	congenics,captured
R5087	T18573	T18572	amod	other,congenics
R5088	T18063	T18058	nsubjpass	markers,typed
R5089	T18574	T18572	punct	(,congenics
R5090	T18575	T18572	appos	HG9,congenics
R5091	T18064	T18063	acl	flanking,markers
R5092	T18576	T18575	punct	", ",HG9
R5093	T18577	T18575	conj	HG11,HG9
R5094	T18578	T18577	cc	and,HG11
R5095	T18065	T18064	dobj	QTL,flanking
R5096	T18579	T18577	conj	HG17,HG11
R5097	T18580	T18566	punct	),captured
R5098	T18581	T18582	compound	hg,modifier
R5099	T18066	T18058	auxpass	were,typed
R5100	T18582	T18583	compound	modifier,QTL
R5101	T18583	T18566	dobj	QTL,captured
R5102	T18584	T18566	punct	.,captured
R5103	T18067	T18058	punct	", ",typed
R5104	T18586	T18587	prep	In,are
R5105	T18068	T18069	cc	not,markers
R5106	T18588	T18589	amod	classical,terms
R5107	T18589	T18586	pobj	terms,In
R5108	T18069	T18058	dep	markers,typed
R5109	T18590	T18587	punct	", ",are
R5110	T18591	T18587	nsubj	they,are
R5111	T18070	T18071	npadvmod	genome,wide
R5112	T18592	T18587	attr	QTL,are
R5113	T18593	T18594	dep	which,modify
R5114	T18594	T18592	relcl	modify,QTL
R5115	T18595	T18596	det	the,expressivity
R5116	T18596	T18594	dobj	expressivity,modify
R5117	T18071	T18069	amod	wide,markers
R5118	T18597	T18596	prep	of,expressivity
R5119	T18598	T18597	pobj	growth,of
R5120	T18599	T18598	cc	and,growth
R5121	T18072	T18071	punct	-,wide
R5122	T18600	T18598	conj	obesity,growth
R5123	T18601	T18596	prep	in,expressivity
R5124	T18073	T18058	punct	.,typed
R5125	T18602	T18603	compound	HG,mice
R5126	T18603	T18601	pobj	mice,in
R5127	T18604	T18605	punct	[,18
R5128	T18075	T18076	prep	In,screened
R5129	T18605	T18587	parataxis	18,are
R5130	T18606	T18605	punct	],18
R5131	T18607	T18587	punct	.,are
R5132	T18077	T18075	pobj	contrast,In
R5133	T18609	T18610	det	These,QTL
R5134	T18610	T18611	nsubj	QTL,are
R5135	T18078	T18076	punct	", ",screened
R5136	T18612	T18611	acomp	novel,are
R5137	T18613	T18614	mark	since,represent
R5138	T18614	T18611	advcl	represent,are
R5139	T18079	T18080	nsubj	we,selected
R5140	T18615	T18614	nsubj	they,represent
R5141	T18616	T18614	dobj	epistasis,represent
R5142	T18080	T18076	ccomp	selected,screened
R5143	T18617	T18616	prep	between,epistasis
R5144	T18618	T18617	pobj	hg,between
R5145	T18619	T18618	cc	and,hg
R5146	T18081	T18080	preconj	not,selected
R5147	T18620	T18621	det	the,gene
R5148	T18621	T18618	conj	gene,hg
R5149	T18622	T18621	compound	modifier,gene
R5150	T18082	T18081	advmod	only,not
R5151	T18623	T18611	punct	.,are
R5152	T18083	T18080	conj	against,selected
R5153	T18625	T18626	compound	QTL,hg
R5154	T18626	T18628	compound	hg,epistasis
R5156	T18084	T18085	amod	known,QTL
R5158	T18085	T18083	pobj	QTL,against
R5159	T18086	T18076	punct	", ",screened
R5160	T18630	T18631	mark	that,are
R5161	T18631	T18629	ccomp	are,implies
R5162	T18087	T18076	nsubj	we,screened
R5163	T18632	T18631	nsubj	Socs2,are
R5164	T18633	T18632	cc	and,Socs2
R5165	T18634	T18635	det	the,modifiers
R5166	T18635	T18632	conj	modifiers,Socs2
R5167	T18636	T18635	compound	hg,modifiers
R5168	T18088	T18076	advmod	also,screened
R5169	T18637	T18631	prep	in,are
R5170	T18638	T18639	det	the,pathway
R5171	T18639	T18637	pobj	pathway,in
R5172	T18089	T18076	prep	for,screened
R5173	T18640	T18639	amod	same,pathway
R5174	T18641	T18639	amod	biological,pathway
R5175	T18090	T18091	npadvmod	genome,wide
R5176	T18642	T18629	punct	.,implies
R5177	T18091	T18092	amod	wide,heterozygosity
R5178	T18644	T18645	advmod	Therefore,are
R5179	T18646	T18645	punct	", ",are
R5180	T18092	T18089	pobj	heterozygosity,for
R5181	T18647	T18648	det	these,QTL
R5182	T18648	T18645	nsubj	QTL,are
R5183	T18093	T18076	advcl	increasing,screened
R5184	T18649	T18645	advmod	likely,are
R5185	T18650	T18645	prep	due,are
R5186	T18651	T18650	pcomp	to,due
R5187	T18094	T18095	det	the,probability
R5188	T18652	T18650	pobj	polymorphism,due
R5189	T18653	T18652	prep	in,polymorphism
R5190	T18654	T18653	pobj	genes,in
R5191	T18095	T18093	dobj	probability,increasing
R5192	T18655	T18654	acl	interacting,genes
R5193	T18656	T18655	prep	with,interacting
R5194	T18096	T18097	mark	that,are
R5195	T18097	T18095	acl	are,probability
R5196	T18098	T18097	nsubj	effects,are
R5197	T18099	T18098	acl	observed,effects
R5198	T18657	T18656	pobj	Gh,with
R5199	T18100	T18097	prep	due,are
R5200	T18658	T18655	punct	", ",interacting
R5201	T18659	T18655	conj	responsive,interacting
R5202	T18660	T18659	prep	to,responsive
R5203	T18101	T18100	pcomp	to,due
R5204	T18661	T18660	pobj	Gh,to
R5205	T18662	T18659	cc	or,responsive
R5206	T18102	T18103	amod	genetic,variation
R5207	T18663	T18664	dep	which,modulate
R5208	T18664	T18659	conj	modulate,responsive
R5209	T18665	T18664	prep	in,modulate
R5210	T18836	T18837	prep	In,is
R5211	T18666	T18667	det	some,way
R5212	T18667	T18665	pobj	way,in
R5213	T18668	T18669	compound	Gh,function
R5214	T18669	T18664	dobj	function,modulate
R5215	T18670	T18645	punct	.,are
R5216	T18672	T18673	det	This,information
R5217	T18673	T18674	nsubj	information,aid
R5218	T18675	T18674	aux	will,aid
R5219	T18676	T18674	advmod	significantly,aid
R5220	T18677	T18678	compound	QTL,cloning
R5221	T18678	T18674	dobj	cloning,aid
R5222	T18679	T18674	prep	by,aid
R5223	T18680	T18679	pcomp	providing,by
R5224	T18681	T18682	det	another,filter
R5225	T18682	T18680	dobj	filter,providing
R5226	T18683	T18684	aux	to,screen
R5227	T18684	T18682	advcl	screen,filter
R5228	T18685	T18684	dobj	candidates,screen
R5229	T18686	T18674	punct	.,aid
R5230	T18688	T18689	amod	Cloning,QTL
R5231	T18689	T18691	nsubj	QTL,has
R5232	T18690	T18689	det	these,QTL
R5233	T18692	T18693	amod	major,implications
R5234	T18693	T18691	dobj	implications,has
R5235	T18694	T18695	aux	to,improve
R5236	T18695	T18693	advcl	improve,implications
R5237	T18696	T18697	poss	our,understanding
R5238	T18838	T18836	pobj	contrast,In
R5239	T18697	T18695	dobj	understanding,improve
R5240	T18698	T18697	prep	of,understanding
R5241	T18699	T18698	pobj	Gh,of
R5242	T18700	T18699	cc	and,Gh
R5243	T18701	T18702	poss	its,regulation
R5244	T18702	T18699	conj	regulation,Gh
R5245	T18839	T18837	punct	", ",is
R5246	T18703	T18702	prep	of,regulation
R5247	T18704	T18703	pobj	growth,of
R5248	T18840	T18841	det	the,strain
R5249	T18705	T18704	cc	and,growth
R5250	T18706	T18704	conj	adiposity,growth
R5251	T18707	T18695	cc	and,improve
R5252	T18841	T18837	nsubj	strain,is
R5253	T18708	T18695	conj	in,improve
R5254	T18709	T18710	det	the,administration
R5255	T18842	T18841	compound	HG9,strain
R5256	T18710	T18708	pobj	administration,in
R5257	T18711	T18710	prep	of,administration
R5258	T18712	T18713	amod	human,Gh
R5259	T18843	T18844	det	an,model
R5260	T18713	T18714	compound	Gh,therapeutics
R5261	T18714	T18711	pobj	therapeutics,of
R5262	T18715	T18691	punct	.,has
R5263	T18844	T18837	attr	model,is
R5264	T18717	T18718	compound	HG1,mice
R5265	T18845	T18846	amod	obese,mouse
R5266	T18718	T18719	nsubj	mice,displayed
R5267	T18720	T18719	dobj	differences,displayed
R5268	T18846	T18844	compound	mouse,model
R5269	T18721	T18722	advmod	only,in
R5270	T18722	T18720	prep	in,differences
R5271	T18723	T18724	compound	growth,traits
R5272	T18724	T18722	pobj	traits,in
R5273	T18725	T18719	punct	.,displayed
R5274	T18847	T18837	punct	.,is
R5275	T18727	T18728	advmod	Originally,had
R5276	T18849	T18850	det	The,strain
R5277	T18729	T18728	punct	", ",had
R5278	T18730	T18728	nsubj	Q1Ucd1,had
R5279	T18731	T18732	amod	small,effects
R5280	T18732	T18728	dobj	effects,had
R5281	T18850	T18851	nsubj	strain,is
R5282	T18733	T18728	cc	and,had
R5283	T18734	T18735	det	these,results
R5284	T18852	T18853	advmod	quite,novel
R5285	T18735	T18736	nsubj	results,illustrate
R5286	T18853	T18851	acomp	novel,is
R5287	T18736	T18728	conj	illustrate,had
R5288	T18854	T18851	prep	for,is
R5289	T18737	T18738	det	the,power
R5290	T18738	T18736	dobj	power,illustrate
R5291	T18739	T18738	prep	of,power
R5292	T18740	T18741	amod	congenic,strain
R5293	T18855	T18856	nummod	two,reasons
R5294	T18856	T18854	pobj	reasons,for
R5295	T18857	T18851	punct	.,is
R5296	T18741	T18742	compound	strain,analysis
R5297	T18859	T18860	advmod	First,was
R5298	T18742	T18739	pobj	analysis,of
R5299	T18743	T18744	aux	to,isolate
R5300	T18861	T18860	punct	", ",was
R5301	T18744	T18738	acl	isolate,power
R5302	T18745	T18746	amod	small,effect
R5303	T18862	T18863	det	the,size
R5304	T18863	T18865	nsubj	size,is
R5305	T18864	T18863	compound	effect,size
R5306	T18865	T18860	ccomp	is,was
R5307	T18746	T18747	compound	effect,QTL
R5308	T18866	T18865	acomp	large,is
R5309	T18747	T18744	dobj	QTL,isolate
R5310	T18867	T18860	punct	;,was
R5311	T18748	T18736	punct	", ",illustrate
R5312	T18749	T18750	mark	although,is
R5313	T18750	T18736	advcl	is,illustrate
R5314	T18868	T18860	nsubj	AI,was
R5315	T18751	T18750	nsubj	it,is
R5316	T18752	T18750	acomp	likely,is
R5317	T18869	T18870	nummod	57,%
R5318	T18753	T18754	det	this,QTL
R5319	T18754	T18755	nsubj	QTL,represents
R5320	T18755	T18752	advcl	represents,likely
R5321	T18756	T18757	det	the,boundary
R5322	T18757	T18755	dobj	boundary,represents
R5323	T18870	T18871	npadvmod	%,higher
R5324	T18758	T18757	amod	lower,boundary
R5325	T18759	T18757	prep	of,boundary
R5326	T18760	T18759	pobj	detection,of
R5327	T18871	T18860	acomp	higher,was
R5328	T18761	T18757	acl	using,boundary
R5329	T18762	T18763	advmod	only,30
R5330	T18872	T18871	prep	in,higher
R5331	T18763	T18766	nummod	30,mice
R5332	T18764	T18763	quantmod	20,30
R5333	T18765	T18763	punct	–,30
R5334	T18873	T18874	compound	HG9,females
R5335	T18766	T18761	dobj	mice,using
R5336	T18767	T18766	amod	congenic,mice
R5337	T18768	T18736	punct	.,illustrate
R5338	T18874	T18872	pobj	females,in
R5339	T18770	T18771	det	The,genes
R5340	T18771	T18775	nsubj	genes,are
R5341	T18875	T18871	cc	and,higher
R5342	T18772	T18773	advmod	most,notable
R5343	T18773	T18771	amod	notable,genes
R5344	T18774	T18771	compound	candidate,genes
R5345	T18876	T18877	nummod	30,%
R5346	T18776	T18771	acl	located,genes
R5347	T18877	T18878	npadvmod	%,higher
R5348	T18777	T18776	prep	within,located
R5349	T18778	T18779	det	the,interval
R5350	T18878	T18871	conj	higher,higher
R5351	T18779	T18777	pobj	interval,within
R5352	T18780	T18779	compound	HG1,interval
R5353	T18879	T18878	prep	in,higher
R5354	T18781	T18782	det	the,transducer
R5355	T18782	T18775	attr	transducer,are
R5356	T18783	T18782	compound	signal,transducer
R5357	T18880	T18879	pobj	males,in
R5358	T18784	T18782	cc	and,transducer
R5359	T18785	T18782	conj	activator,transducer
R5360	T18881	T18860	punct	.,was
R5361	T18786	T18785	prep	of,activator
R5362	T18787	T18786	pobj	transcription,of
R5363	T18788	T18787	nummod	1,transcription
R5364	T18883	T18884	advmod	Secondly,is
R5365	T18789	T18787	punct	(,transcription
R5366	T18790	T18787	appos	Stat1,transcription
R5367	T18791	T18787	punct	),transcription
R5368	T18885	T18884	punct	", ",is
R5369	T18792	T18787	cc	and,transcription
R5370	T18793	T18787	conj	Stat4,transcription
R5371	T18794	T18775	punct	.,are
R5372	T18886	T18884	nsubj	it,is
R5373	T18796	T18797	nsubj	Two,had
R5374	T18798	T18796	prep	of,Two
R5375	T18799	T18800	det	the,congenics
R5376	T18800	T18798	pobj	congenics,of
R5377	T18887	T18884	acomp	dependent,is
R5378	T18801	T18802	amod	major,alterations
R5379	T18802	T18797	dative	alterations,had
R5380	T18888	T18887	prep	on,dependent
R5381	T18803	T18802	prep	in,alterations
R5382	T18804	T18805	det	the,deposition
R5383	T18805	T18803	pobj	deposition,in
R5384	T18889	T18888	pobj	hg,on
R5385	T18806	T18805	prep	of,deposition
R5386	T18807	T18808	compound	adipose,tissue
R5387	T18808	T18806	pobj	tissue,of
R5388	T18890	T18884	prep	for,is
R5389	T18809	T18797	punct	", ",had
R5390	T18810	T18797	dobj	HG8,had
R5391	T18811	T18810	cc	and,HG8
R5392	T18891	T18892	poss	its,expression
R5393	T18812	T18810	conj	HG9,HG8
R5394	T18813	T18797	punct	.,had
R5395	T18892	T18890	pobj	expression,for
R5396	T18815	T18816	det	The,region
R5397	T18893	T18884	punct	.,is
R5398	T18816	T18819	nsubj	region,promotes
R5399	T18817	T18816	compound	HG8,region
R5400	T18895	T18896	det	The,strain
R5401	T18818	T18816	compound	donor,region
R5402	T18820	T18819	dobj	leanness,promotes
R5403	T18821	T18819	punct	.,promotes
R5404	T18896	T18898	nsubj	strain,represents
R5405	T18823	T18824	amod	Congenic,females
R5406	T18897	T18896	compound	HG9,strain
R5407	T18824	T18825	nsubj	females,displayed
R5408	T18826	T18827	det	a,reduction
R5409	T18899	T18900	det	a,model
R5410	T18827	T18825	dobj	reduction,displayed
R5411	T18828	T18827	prep	of,reduction
R5412	T18829	T18830	quantmod	over,25
R5413	T18900	T18898	dobj	model,represents
R5414	T18830	T18831	nummod	25,%
R5415	T18831	T18828	pobj	%,of
R5416	T18901	T18900	amod	major,model
R5417	T18832	T18827	prep	in,reduction
R5418	T18833	T18832	pobj	AI,in
R5419	T18834	T18825	punct	.,displayed
R5420	T18902	T18903	npadvmod	epistasis,based
R5421	T18903	T18900	amod	based,model
R5422	T18904	T18903	punct	-,based
R5423	T18905	T18906	amod	obese,mouse
R5424	T18906	T18900	compound	mouse,model
R5425	T18907	T18898	cc	and,represents
R5426	T18908	T18898	conj	promises,represents
R5427	T18909	T18910	aux	to,aid
R5428	T18910	T18908	xcomp	aid,promises
R5429	T18911	T18910	prep	in,aid
R5430	T18912	T18913	det	the,understanding
R5431	T18913	T18911	pobj	understanding,in
R5432	T18914	T18913	prep	of,understanding
R5433	T18915	T18914	pobj	obesity,of
R5434	T19201	T19202	npadvmod	sex,specific
R5435	T18916	T18913	cc	and,understanding
R5436	T19202	T19200	amod	specific,phenotypes
R5437	T19203	T19202	punct	-,specific
R5438	T18917	T18918	advmod	specifically,modulation
R5439	T19204	T19200	prep	in,phenotypes
R5440	T19205	T19206	compound	HG11,mice
R5441	T19206	T19204	pobj	mice,in
R5442	T18918	T18913	conj	modulation,understanding
R5443	T19207	T19208	mark	since,is
R5444	T19208	T19192	advcl	is,explain
R5445	T18919	T18918	det	the,modulation
R5446	T19209	T19208	nsubj	it,is
R5447	T19210	T19211	det	the,factor
R5448	T19211	T19208	attr	factor,is
R5449	T18920	T18918	prep	of,modulation
R5450	T19212	T19211	amod	primary,factor
R5451	T19213	T19211	compound	transcription,factor
R5452	T19214	T19211	amod	responsible,factor
R5453	T18921	T18922	compound	adipose,tissue
R5454	T19215	T19214	prep	for,responsible
R5455	T19216	T19217	npadvmod	Gh,induced
R5456	T19217	T19218	amod	induced,expression
R5457	T18922	T18923	compound	tissue,deposition
R5458	T19218	T19215	pobj	expression,for
R5459	T19219	T19220	npadvmod	sex,specific
R5460	T19220	T19218	amod	specific,expression
R5461	T18923	T18920	pobj	deposition,of
R5462	T19221	T19220	punct	-,specific
R5463	T19222	T19223	compound	liver,gene
R5464	T18924	T18918	prep	by,modulation
R5465	T19223	T19218	compound	gene,expression
R5466	T19224	T19225	punct	[,44
R5467	T19225	T19192	parataxis	44,explain
R5468	T18925	T18924	pobj	Gh,by
R5469	T19226	T19225	punct	],44
R5470	T19227	T19192	punct	.,explain
R5471	T18926	T18898	punct	.,represents
R5472	T19229	T19230	amod	Future,studies
R5473	T19230	T19231	nsubj	studies,include
R5474	T19232	T19230	acl	aimed,studies
R5475	T19233	T19232	prep	at,aimed
R5476	T19234	T19233	pcomp	identifying,at
R5477	T19235	T19236	det	the,QTG
R5478	T19236	T19234	dobj	QTG,identifying
R5479	T19237	T19236	compound	HG11,QTG
R5480	T19238	T19231	punct	", ",include
R5481	T19239	T19231	aux	will,include
R5482	T19240	T19231	advmod	certainly,include
R5483	T19241	T19242	det	a,characterization
R5484	T18928	T18929	nsubj	Studies,are
R5485	T19242	T19231	dobj	characterization,include
R5486	T19243	T19242	amod	thorough,characterization
R5487	T19244	T19242	prep	of,characterization
R5488	T19245	T19246	nmod	Gh,patterns
R5489	T18930	T18929	advmod	currently,are
R5490	T19246	T19244	pobj	patterns,of
R5491	T19247	T19245	cc	and,Gh
R5492	T19248	T19245	conj	Stat5b,Gh
R5493	T19249	T19246	nmod	sequence,patterns
R5494	T18931	T18929	acomp	underway,are
R5495	T19250	T19249	cc	and,sequence
R5496	T19251	T19249	conj	expression,sequence
R5497	T18932	T18933	aux	to,identify
R5498	T19252	T19246	prep	in,patterns
R5499	T19253	T19254	amod	congenic,mice
R5500	T19254	T19252	pobj	mice,in
R5501	T18933	T18929	advcl	identify,are
R5502	T19255	T19231	punct	.,include
R5503	T18934	T18935	det	the,mutation
R5504	T19257	T19258	det	The,QTL
R5505	T19258	T19261	nsubj	QTL,had
R5506	T19259	T19260	compound	hg,modifier
R5507	T18935	T18933	dobj	mutation,identify
R5508	T19260	T19258	compound	modifier,QTL
R5509	T19262	T19258	acl	located,QTL
R5510	T18936	T18935	amod	causative,mutation
R5511	T19263	T19262	prep	within,located
R5512	T19264	T19265	det	the,strain
R5513	T19265	T19263	pobj	strain,within
R5514	T18937	T18933	cc	and,identify
R5515	T18938	T18939	aux	to,characterize
R5516	T19266	T19265	compound	HG17,strain
R5517	T18939	T18933	conj	characterize,identify
R5518	T19267	T19268	amod	large,effects
R5519	T19268	T19261	dobj	effects,had
R5520	T18940	T18941	det	the,effects
R5521	T19269	T19268	prep	on,effects
R5522	T19270	T19269	pobj	growth,on
R5523	T19271	T19270	punct	", ",growth
R5524	T18941	T18939	dobj	effects,characterize
R5525	T19272	T19273	compound	body,length
R5526	T19273	T19270	conj	length,growth
R5527	T18942	T18941	prep	of,effects
R5528	T19274	T19273	cc	and,length
R5529	T19275	T19276	compound	carcass,components
R5530	T18943	T18942	pobj	age,of
R5531	T18944	T18943	cc	and,age
R5532	T18945	T18943	conj	diet,age
R5533	T19276	T19273	conj	components,length
R5534	T18946	T18941	prep	on,effects
R5535	T19277	T19261	punct	.,had
R5536	T18947	T18946	pobj	obesity,on
R5537	T19279	T19280	det	The,gene
R5538	T18948	T18947	prep	in,obesity
R5539	T19280	T19284	nsubj	gene,is
R5540	T19281	T19282	advmod	most,intriguing
R5541	T19282	T19280	amod	intriguing,gene
R5542	T18949	T18950	det	this,strain
R5543	T19283	T19280	compound	candidate,gene
R5544	T18950	T18948	pobj	strain,in
R5545	T19285	T19280	acl	located,gene
R5546	T19286	T19285	prep	in,located
R5547	T19287	T19288	det	the,congenic
R5548	T18951	T18952	advmod	as,as
R5549	T19288	T19286	pobj	congenic,in
R5550	T19289	T19284	attr	Sstr5,is
R5551	T19290	T19284	punct	.,is
R5552	T18952	T18941	cc	as,effects
R5553	T19292	T19293	nsubj	Somatostatin,is
R5554	T18953	T18952	advmod	well,as
R5555	T19294	T19295	det	a,inhibitor
R5556	T18954	T18941	conj	testing,effects
R5557	T19295	T19293	attr	inhibitor,is
R5558	T19296	T19295	amod	potent,inhibitor
R5559	T18955	T18954	prep	for,testing
R5560	T19297	T19295	prep	of,inhibitor
R5561	T19298	T19297	pobj	Gh,of
R5562	T19299	T19293	cc	and,is
R5563	T18956	T18957	amod	other,consequences
R5564	T19300	T19301	nsubj	Sstr5,is
R5565	T19301	T19293	conj	is,is
R5566	T19302	T19301	attr	one,is
R5567	T18957	T18955	pobj	consequences,for
R5568	T19303	T19302	prep	of,one
R5569	T19304	T19305	nummod	five,receptors
R5570	T18958	T18957	amod	physiological,consequences
R5571	T19305	T19303	pobj	receptors,of
R5572	T19306	T19307	dep	which,mediate
R5573	T19307	T19305	relcl	mediate,receptors
R5574	T18959	T18960	amod	such,as
R5575	T19308	T19309	det	these,effects
R5576	T19309	T19307	dobj	effects,mediate
R5577	T18960	T18957	prep	as,consequences
R5578	T19310	T19311	punct	[,46
R5579	T19311	T19301	parataxis	46,is
R5580	T19312	T19311	nummod	45,46
R5581	T19313	T19311	punct	",",46
R5582	T19314	T19311	punct	],46
R5583	T19315	T19301	punct	.,is
R5584	T18961	T18960	pobj	alterations,as
R5585	T19317	T19318	amod	Ubiquitous,knockout
R5586	T18962	T18961	prep	in,alterations
R5587	T19318	T19324	nsubj	knockout,leads
R5588	T19319	T19317	cc	and,Ubiquitous
R5589	T19320	T19321	amod	pancreatic,cell
R5590	T18963	T18964	compound	food,intake
R5591	T19321	T19323	npadvmod	cell,specific
R5592	T19322	T19321	compound	beta,cell
R5593	T19323	T19317	conj	specific,Ubiquitous
R5594	T18964	T18962	pobj	intake,in
R5595	T19325	T19318	prep	of,knockout
R5596	T19326	T19325	pobj	Sstr5,of
R5597	T18965	T18964	cc	and,intake
R5598	T19327	T19324	prep	to,leads
R5599	T19328	T19327	pobj	alterations,to
R5600	T18966	T18967	compound	insulin,sensitivity
R5601	T19329	T19328	prep	in,alterations
R5602	T19330	T19331	compound	insulin,secretion
R5603	T19331	T19329	pobj	secretion,in
R5604	T18967	T18964	conj	sensitivity,intake
R5605	T19332	T19331	cc	and,secretion
R5606	T19333	T19334	compound	glucose,homeostasis
R5607	T18968	T18929	punct	.,are
R5608	T19334	T19331	conj	homeostasis,secretion
R5609	T19335	T19336	punct	[,48
R5610	T19336	T19324	parataxis	48,leads
R5611	T18970	T18971	det	The,strain
R5612	T19337	T19336	nummod	47,48
R5613	T19338	T19336	punct	",",48
R5614	T19339	T19336	punct	],48
R5615	T19340	T19324	punct	.,leads
R5616	T18971	T18973	nsubj	strain,is
R5617	T19342	T19343	nsubj	We,sequenced
R5618	T18972	T18971	compound	HG11,strain
R5619	T19344	T19345	compound	candidate,genes
R5620	T19345	T19343	dobj	genes,sequenced
R5621	T18974	T18973	prep	of,is
R5622	T19346	T19347	compound	hg,modifier
R5623	T19347	T19345	compound	modifier,genes
R5624	T19348	T19349	aux	to,complement
R5625	T19349	T19343	advcl	complement,sequenced
R5626	T18975	T18976	amod	particular,interest
R5627	T19350	T19351	det	the,characterization
R5628	T19351	T19349	dobj	characterization,complement
R5629	T18976	T18974	pobj	interest,of
R5630	T19352	T19351	prep	of,characterization
R5631	T19353	T19354	det	the,congenics
R5632	T19354	T19352	pobj	congenics,of
R5633	T19355	T19354	compound	speed,congenics
R5634	T19356	T19354	prep	on,congenics
R5635	T19357	T19358	nmod	MMU,2
R5636	T18977	T18973	prep	for,is
R5637	T19358	T19356	pobj	2,on
R5638	T19359	T19358	punct	", ",2
R5639	T19360	T19358	conj	9,2
R5640	T18978	T18979	det	a,number
R5641	T19361	T19360	punct	", ",9
R5642	T19362	T19360	conj	11,9
R5643	T18979	T18977	pobj	number,for
R5644	T19363	T19362	cc	and,11
R5645	T19364	T19362	conj	17,11
R5646	T18980	T18979	prep	of,number
R5647	T18981	T18980	pobj	reasons,of
R5648	T18982	T18973	punct	.,is
R5649	T18984	T18985	advmod	First,demonstrated
R5650	T19365	T19343	punct	.,sequenced
R5651	T18986	T18985	punct	", ",demonstrated
R5652	T19367	T19368	det	A,number
R5653	T19368	T19370	nsubj	number,identified
R5654	T19369	T19368	amod	limited,number
R5655	T18987	T18988	npadvmod	HG11,congenic
R5656	T19371	T19368	prep	of,number
R5657	T18988	T18989	amod	congenic,mice
R5658	T18989	T18985	nsubj	mice,demonstrated
R5659	T19372	T19371	pobj	studies,of
R5660	T19373	T19370	aux	have,identified
R5661	T18990	T18991	amod	significant,interactions
R5662	T19374	T19370	dobj	variation,identified
R5663	T19375	T19374	prep	within,variation
R5664	T18991	T18985	dobj	interactions,demonstrated
R5665	T19376	T19377	compound	CAST,sequence
R5666	T19377	T19375	pobj	sequence,within
R5667	T19378	T19377	compound	coding,sequence
R5668	T18992	T18991	nmod	strain,interactions
R5669	T19379	T19370	punct	;,identified
R5670	T19380	T19370	cc	so,identified
R5671	T18993	T18992	prep	by,strain
R5672	T19381	T19382	amod	sequencing,candidates
R5673	T19382	T19383	nsubj	candidates,gave
R5674	T19383	T19370	conj	gave,identified
R5675	T18994	T18993	pobj	sex,by
R5676	T19384	T19383	dative	us,gave
R5677	T19385	T19386	det	the,opportunity
R5678	T18995	T18985	prep	for,demonstrated
R5679	T19386	T19383	dobj	opportunity,gave
R5680	T19387	T19388	aux	to,estimate
R5681	T18996	T18997	det	a,number
R5682	T19388	T19386	acl	estimate,opportunity
R5683	T19389	T19390	det	the,frequency
R5684	T19390	T19388	dobj	frequency,estimate
R5685	T19391	T19390	compound	SNP,frequency
R5686	T19392	T19390	prep	in,frequency
R5687	T18997	T18995	pobj	number,for
R5688	T19393	T19394	compound	coding,sequence
R5689	T19394	T19392	pobj	sequence,in
R5690	T19395	T19388	advcl	relative,estimate
R5691	T18998	T18997	prep	of,number
R5692	T19396	T19395	prep	to,relative
R5693	T19397	T19396	pobj	B6,to
R5694	T19398	T19383	punct	.,gave
R5695	T18999	T18998	pobj	traits,of
R5696	T19400	T19401	det	This,information
R5697	T19000	T18985	punct	.,demonstrated
R5698	T19401	T19402	nsubj	information,be
R5699	T19403	T19402	aux	will,be
R5700	T19002	T19003	nsubj	Males,were
R5701	T19404	T19402	acomp	vital,be
R5702	T19405	T19404	prep	to,vital
R5703	T19406	T19407	amod	future,studies
R5704	T19004	T19005	advmod	generally,larger
R5705	T19407	T19405	pobj	studies,to
R5706	T19408	T19409	amod	fine,mapping
R5707	T19409	T19407	compound	mapping,studies
R5708	T19410	T19407	punct	", ",studies
R5709	T19005	T19003	acomp	larger,were
R5710	T19411	T19412	dep	which,include
R5711	T19412	T19407	relcl	include,studies
R5712	T19413	T19412	aux	will,include
R5713	T19006	T19005	punct	", ",larger
R5714	T19414	T19415	compound	gene,expression
R5715	T19415	T19416	compound	expression,analysis
R5716	T19416	T19412	dobj	analysis,include
R5717	T19007	T19008	amod	faster,growing
R5718	T19417	T19402	punct	.,be
R5719	T19008	T19005	conj	growing,larger
R5720	T19419	T19420	det	The,frequency
R5721	T19420	T19423	nsubj	frequency,lead
R5722	T19421	T19420	amod	high,frequency
R5723	T19009	T19008	cc	and,growing
R5724	T19422	T19420	compound	SNP,frequency
R5725	T19424	T19425	punct	(,SNP
R5726	T19010	T19008	conj	longer,growing
R5727	T19425	T19420	parataxis	SNP,frequency
R5728	T19426	T19427	nummod	0.312,%
R5729	T19427	T19425	dep	%,SNP
R5730	T19011	T19003	cc	and,were
R5731	T19428	T19425	punct	;,SNP
R5732	T19429	T19425	nummod	295,SNP
R5733	T19012	T19013	det	the,converse
R5734	T19430	T19425	prep	in,SNP
R5735	T19431	T19432	nummod	94.492,kbp
R5736	T19432	T19430	pobj	kbp,in
R5737	T19433	T19425	punct	),SNP
R5738	T19434	T19420	prep	in,frequency
R5739	T19435	T19436	compound	CAST,genes
R5740	T19013	T19014	nsubjpass	converse,seen
R5741	T19436	T19434	pobj	genes,in
R5742	T19437	T19423	aux	may,lead
R5743	T19438	T19423	prep	to,lead
R5744	T19014	T19003	conj	seen,were
R5745	T19439	T19440	det	a,rate
R5746	T19440	T19438	pobj	rate,to
R5747	T19441	T19440	amod	higher,rate
R5748	T19442	T19440	prep	of,rate
R5749	T19443	T19444	amod	false,positives
R5750	T19444	T19442	pobj	positives,of
R5751	T19445	T19444	acl	using,positives
R5752	T19446	T19447	compound	DNA,microarrays
R5753	T19447	T19445	dobj	microarrays,using
R5754	T19448	T19447	cc	or,microarrays
R5755	T19015	T19014	auxpass	was,seen
R5756	T19449	T19450	amod	quantitative,assays
R5757	T19016	T19014	prep	in,seen
R5758	T19017	T19016	pobj	females,in
R5759	T19018	T19014	punct	.,seen
R5760	T19020	T19021	det	The,effects
R5761	T19450	T19447	conj	assays,microarrays
R5762	T19021	T19023	nsubj	effects,are
R5763	T19451	T19452	amod	real,time
R5764	T19452	T19450	compound	time,assays
R5765	T19453	T19452	punct	-,time
R5766	T19022	T19021	amod	confounding,effects
R5767	T19454	T19450	compound	PCR,assays
R5768	T19455	T19447	punct	", ",microarrays
R5769	T19024	T19021	prep	of,effects
R5770	T19456	T19457	dep	most,based
R5771	T19457	T19447	relcl	based,microarrays
R5772	T19458	T19456	prep	of,most
R5773	T19459	T19458	pobj	which,of
R5774	T19025	T19024	pobj	sex,of
R5775	T19460	T19457	auxpass	are,based
R5776	T19461	T19457	prep	on,based
R5777	T19462	T19463	compound	B6,sequence
R5778	T19026	T19023	advmod	likely,are
R5779	T19463	T19461	pobj	sequence,on
R5780	T19464	T19423	punct	.,lead
R5781	T19027	T19028	det	the,reason
R5782	T19466	T19467	advmod	Therefore,used
R5783	T19028	T19023	attr	reason,are
R5784	T19468	T19467	punct	", ",used
R5785	T19469	T19470	det	these,data
R5786	T19470	T19467	nsubjpass	data,used
R5787	T19029	T19028	prep	for,reason
R5788	T19471	T19470	compound	sequence,data
R5789	T19472	T19467	aux	can,used
R5790	T19473	T19467	auxpass	be,used
R5791	T19474	T19475	aux	to,guide
R5792	T19475	T19467	advcl	guide,used
R5793	T19476	T19477	det	the,development
R5794	T19030	T19031	det	the,discrepancies
R5795	T19477	T19475	dobj	development,guide
R5796	T19031	T19029	pobj	discrepancies,for
R5797	T19032	T19031	prep	between,discrepancies
R5798	T19478	T19477	prep	of,development
R5799	T19479	T19480	compound	gene,expression
R5800	T19480	T19481	compound	expression,assays
R5801	T19033	T19034	det	the,results
R5802	T19481	T19478	pobj	assays,of
R5803	T19482	T19483	aux	to,confirm
R5804	T19034	T19032	pobj	results,between
R5805	T19483	T19475	advcl	confirm,guide
R5806	T19484	T19485	amod	differential,expression
R5807	T19485	T19483	dobj	expression,confirm
R5808	T19035	T19036	amod	congenic,genome
R5809	T19486	T19483	prep	for,confirm
R5810	T19487	T19486	pobj	candidates,for
R5811	T19036	T19038	compound	genome,scan
R5812	T19488	T19467	cc	and,used
R5813	T19489	T19467	conj	suggests,used
R5814	T19037	T19036	cc	and,genome
R5815	T19490	T19491	mark	that,sequenced
R5816	T19491	T19489	ccomp	sequenced,suggests
R5817	T19492	T19491	nsubjpass	genes,sequenced
R5818	T19493	T19492	acl	identified,genes
R5819	T19038	T19034	compound	scan,results
R5820	T19494	T19493	prep	by,identified
R5821	T19495	T19496	amod	downstream,experiments
R5822	T19039	T19034	punct	", ",results
R5823	T19496	T19494	pobj	experiments,by
R5824	T19497	T19491	aux	should,sequenced
R5825	T19498	T19491	advmod	also,sequenced
R5826	T19040	T19041	advmod	where,analyzed
R5827	T19499	T19491	auxpass	be,sequenced
R5828	T19500	T19467	punct	.,used
R5829	T19041	T19034	relcl	analyzed,results
R5830	T19502	T19503	advmod	More,importantly
R5831	T19503	T19504	advmod	importantly,allowed
R5832	T19042	T19043	det	both,sexes
R5833	T19505	T19504	punct	", ",allowed
R5834	T19506	T19504	csubj	sequencing,allowed
R5835	T19043	T19041	nsubjpass	sexes,analyzed
R5836	T19507	T19508	compound	hg,modifier
R5837	T19508	T19509	compound	modifier,candidates
R5838	T19509	T19506	dobj	candidates,sequencing
R5839	T19044	T19041	auxpass	were,analyzed
R5840	T19510	T19511	nsubj	us,identify
R5841	T19511	T19504	ccomp	identify,allowed
R5842	T19512	T19511	aux	to,identify
R5843	T19513	T19514	amod	nonsynonomous,polymorphism
R5844	T19514	T19511	dobj	polymorphism,identify
R5845	T19515	T19514	punct	", ",polymorphism
R5846	T19045	T19041	advmod	together,analyzed
R5847	T19516	T19517	dep	which,underlie
R5848	T19517	T19514	relcl	underlie,polymorphism
R5849	T19518	T19517	aux	may,underlie
R5850	T19046	T19023	punct	.,are
R5851	T19519	T19517	dobj	QTL,underlie
R5852	T19520	T19504	punct	.,allowed
R5853	T19048	T19049	advmod	Secondly,found
R5854	T19522	T19523	nsubj	SIFT,predicted
R5855	T19524	T19522	cc	and,SIFT
R5856	T19525	T19524	punct	/,and
R5857	T19050	T19049	punct	", ",found
R5858	T19526	T19524	cc	or,and
R5859	T19527	T19522	conj	PolyPhen,SIFT
R5860	T19528	T19523	dobj	alterations,predicted
R5861	T19529	T19528	prep	in,alterations
R5862	T19051	T19049	nsubjpass	Carp2,found
R5863	T19530	T19531	compound	protein,function
R5864	T19531	T19529	pobj	function,in
R5865	T19052	T19049	auxpass	was,found
R5866	T19532	T19528	prep	for,alterations
R5867	T19533	T19532	pobj	15,for
R5868	T19534	T19533	prep	of,15
R5869	T19053	T19054	aux	to,interact
R5870	T19535	T19536	det	the,nsSNP
R5871	T19536	T19534	pobj	nsSNP,of
R5872	T19054	T19049	xcomp	interact,found
R5873	T19055	T19054	prep	with,interact
R5874	T19056	T19055	pobj	hg,with
R5875	T19057	T19049	cc	and,found
R5876	T19058	T19059	nsubjpass	MMU11,saturated
R5877	T19537	T19536	nummod	56,nsSNP
R5878	T19538	T19536	amod	total,nsSNP
R5879	T19059	T19049	conj	saturated,found
R5880	T19060	T19059	auxpass	is,saturated
R5881	T19061	T19059	prep	with,saturated
R5882	T19062	T19061	pobj	genes,with
R5883	T19063	T19062	acl	involved,genes
R5884	T19539	T19540	punct	(,%
R5885	T19064	T19063	prep	in,involved
R5886	T19540	T19533	parataxis	%,15
R5887	T19541	T19540	nummod	27,%
R5888	T19065	T19066	det	the,pathway
R5889	T19542	T19540	punct	),%
R5890	T19543	T19533	prep	in,15
R5891	T19066	T19064	pobj	pathway,in
R5892	T19544	T19543	pobj	nine,in
R5893	T19545	T19544	prep	of,nine
R5894	T19546	T19547	det	the,genes
R5895	T19547	T19545	pobj	genes,of
R5896	T19548	T19547	nummod	44,genes
R5897	T19067	T19066	amod	central,pathway
R5898	T19549	T19547	amod	total,genes
R5899	T19550	T19551	punct	(,%
R5900	T19551	T19543	parataxis	%,in
R5901	T19068	T19066	nmod	Gh,pathway
R5902	T19552	T19551	nummod	20,%
R5903	T19553	T19551	punct	),%
R5904	T19069	T19066	amod	intracellular,pathway
R5905	T19554	T19555	punct	(,Table
R5906	T19555	T19523	parataxis	Table,predicted
R5907	T19556	T19555	nummod	7,Table
R5908	T19070	T19066	compound	signaling,pathway
R5909	T19557	T19555	punct	),Table
R5910	T19558	T19523	punct	.,predicted
R5911	T19071	T19062	punct	", ",genes
R5912	T19560	T19561	nsubjpass	It,shown
R5913	T19072	T19073	amod	such,as
R5914	T19562	T19561	aux	has,shown
R5915	T19563	T19561	auxpass	been,shown
R5916	T19073	T19062	prep	as,genes
R5917	T19564	T19565	mark	that,is
R5918	T19565	T19561	ccomp	is,shown
R5919	T19566	T19565	csubj	predicting,is
R5920	T19074	T19073	pobj	Gh,as
R5921	T19075	T19074	punct	", ",Gh
R5922	T19076	T19074	conj	Stat5b,Gh
R5923	T19077	T19076	cc	and,Stat5b
R5924	T19567	T19566	dobj	function,predicting
R5925	T19568	T19566	prep	based,predicting
R5926	T19078	T19076	conj	Stat5a,Stat5b
R5927	T19569	T19568	prep	on,based
R5928	T19570	T19571	amod	evolutionary,conservation
R5929	T19571	T19569	pobj	conservation,on
R5930	T19079	T19049	punct	.,found
R5931	T19572	T19566	advcl	using,predicting
R5932	T19573	T19572	dobj	programs,using
R5933	T19574	T19575	amod	such,as
R5934	T19081	T19082	advmod	Thirdly,identified
R5935	T19575	T19573	prep	as,programs
R5936	T19576	T19575	pobj	SIFT,as
R5937	T19577	T19576	cc	and,SIFT
R5938	T19083	T19082	punct	", ",identified
R5939	T19578	T19576	conj	PolyPhen,SIFT
R5940	T19579	T19580	advmod	very,accurate
R5941	T19580	T19565	acomp	accurate,is
R5942	T19581	T19582	punct	[,49
R5943	T19084	T19085	compound	MMU11,QTL
R5944	T19582	T19561	parataxis	49,shown
R5945	T19583	T19582	punct	],49
R5946	T19085	T19082	nsubjpass	QTL,identified
R5947	T19584	T19561	punct	.,shown
R5948	T19586	T19587	nsubj	Four,are
R5949	T19086	T19085	compound	growth,QTL
R5950	T19588	T19586	prep	of,Four
R5951	T19589	T19590	det	the,genes
R5952	T19087	T19085	acl	overlapping,QTL
R5953	T19590	T19588	pobj	genes,of
R5954	T19591	T19590	nummod	nine,genes
R5955	T19088	T19087	dobj	HG11,overlapping
R5956	T19592	T19586	punct	(,Four
R5957	T19593	T19586	appos	Ubr1,Four
R5958	T19594	T19593	punct	", ",Ubr1
R5959	T19089	T19082	aux	have,identified
R5960	T19595	T19593	conj	Ptpns1,Ubr1
R5961	T19596	T19595	punct	", ",Ptpns1
R5962	T19090	T19082	auxpass	been,identified
R5963	T19597	T19595	conj	Ubce7ip5,Ptpns1
R5964	T19598	T19597	cc	and,Ubce7ip5
R5965	T19091	T19082	prep	in,identified
R5966	T19599	T19597	conj	Mmp9,Ubce7ip5
R5967	T19600	T19593	punct	;,Ubr1
R5968	T19092	T19093	det	a,number
R5969	T19601	T19602	dep	all,are
R5970	T19602	T19593	relcl	are,Ubr1
R5971	T19603	T19601	prep	of,all
R5972	T19093	T19091	pobj	number,in
R5973	T19604	T19603	pobj	which,of
R5974	T19605	T19602	prep	on,are
R5975	T19606	T19605	pobj	MMU2,on
R5976	T19094	T19093	prep	of,number
R5977	T19607	T19587	punct	),are
R5978	T19608	T19587	prep	of,are
R5979	T19609	T19610	amod	particular,interest
R5980	T19095	T19094	pobj	crosses,of
R5981	T19610	T19608	pobj	interest,of
R5982	T19611	T19587	punct	.,are
R5983	T19096	T19082	advcl	using,identified
R5984	T19613	T19614	nsubjpass	It,suggested
R5985	T19097	T19098	amod	different,strains
R5986	T19615	T19614	aux	has,suggested
R5987	T19616	T19614	auxpass	been,suggested
R5988	T19098	T19096	dobj	strains,using
R5989	T19617	T19618	det	the,Socs2
R5990	T19618	T19619	nsubj	Socs2,rely
R5991	T19619	T19614	advcl	rely,suggested
R5992	T19099	T19098	compound	mouse,strains
R5993	T19620	T19619	aux	may,rely
R5994	T19621	T19619	prep	on,rely
R5995	T19100	T19101	punct	[,37
R5996	T19622	T19623	npadvmod	ubiquitination,dependent
R5997	T19623	T19624	amod	dependent,degradation
R5998	T19624	T19621	pobj	degradation,on
R5999	T19625	T19624	amod	proteasomal,degradation
R6000	T19101	T19082	parataxis	37,identified
R6001	T19102	T19103	punct	-,41
R6002	T19626	T19627	aux	to,inhibit
R6003	T19627	T19619	advcl	inhibit,rely
R6004	T19628	T19629	compound	Gh,signaling
R6005	T19629	T19627	dobj	signaling,inhibit
R6006	T19630	T19631	punct	[,23
R6007	T19103	T19101	prep	41,37
R6008	T19631	T19614	parataxis	23,suggested
R6009	T19632	T19631	punct	],23
R6010	T19633	T19614	punct	.,suggested
R6011	T19104	T19101	punct	],37
R6012	T19635	T19636	nsubjpass	Ubr1,involved
R6013	T19105	T19082	punct	.,identified
R6014	T19637	T19635	cc	and,Ubr1
R6015	T19638	T19635	conj	Ubce7ip5,Ubr1
R6016	T19107	T19108	advcl	Given,is
R6017	T19639	T19636	auxpass	are,involved
R6018	T19640	T19636	advmod	both,involved
R6019	T19641	T19636	prep	in,involved
R6020	T19642	T19643	compound	protein,ubiquitination
R6021	T19109	T19110	det	the,nature
R6022	T19643	T19641	pobj	ubiquitination,in
R6023	T19644	T19636	cc	and,involved
R6024	T19645	T19646	compound	Ubr1,knockout
R6025	T19646	T19647	compound	knockout,mice
R6026	T19110	T19107	dobj	nature,Given
R6027	T19647	T19648	nsubj	mice,show
R6028	T19648	T19636	conj	show,involved
R6029	T19111	T19112	advmod	well,documented
R6030	T19649	T19650	det	an,decrease
R6031	T19650	T19648	dobj	decrease,show
R6032	T19651	T19652	nummod	20,%
R6033	T19112	T19110	amod	documented,nature
R6034	T19652	T19650	compound	%,decrease
R6035	T19653	T19650	prep	in,decrease
R6036	T19654	T19655	compound	body,weight
R6037	T19113	T19114	advmod	sexually,dimorphic
R6038	T19655	T19653	pobj	weight,in
R6039	T19656	T19657	advmod	partly,due
R6040	T19114	T19110	amod	dimorphic,nature
R6041	T19657	T19648	prep	due,show
R6042	T19658	T19657	pcomp	to,due
R6043	T19659	T19660	det	a,reduction
R6044	T19115	T19110	prep	of,nature
R6045	T19660	T19657	pobj	reduction,due
R6046	T19661	T19660	prep	in,reduction
R6047	T19116	T19117	compound	Gh,secretion
R6048	T19662	T19663	compound	adipose,tissue
R6049	T19663	T19661	pobj	tissue,in
R6050	T19664	T19665	punct	[,51
R6051	T19665	T19648	parataxis	51,show
R6052	T19666	T19665	nummod	50,51
R6053	T19667	T19665	punct	",",51
R6054	T19117	T19115	pobj	secretion,of
R6055	T19668	T19665	punct	],51
R6056	T19669	T19648	punct	.,show
R6057	T19118	T19117	cc	and,secretion
R6058	T19671	T19672	compound	Ptpns1,mice
R6059	T19672	T19674	nsubj	mice,displayed
R6060	T19119	T19120	npadvmod	Gh,induced
R6061	T19673	T19672	compound	knockout,mice
R6062	T19120	T19121	amod	induced,expression
R6063	T19675	T19676	det	a,reduction
R6064	T19676	T19674	dobj	reduction,displayed
R6065	T19677	T19678	nummod	10,%
R6066	T19121	T19117	conj	expression,secretion
R6067	T19678	T19676	compound	%,reduction
R6068	T19679	T19676	prep	in,reduction
R6069	T19680	T19681	compound	body,weight
R6070	T19122	T19121	compound	gene,expression
R6071	T19681	T19679	pobj	weight,in
R6072	T19682	T19683	punct	[,52
R6073	T19123	T19124	punct	[,43
R6074	T19683	T19674	parataxis	52,displayed
R6075	T19684	T19683	punct	],52
R6076	T19685	T19674	cc	and,displayed
R6077	T19124	T19107	parataxis	43,Given
R6078	T19686	T19687	compound	Mmp9,mice
R6079	T19687	T19689	nsubj	mice,show
R6080	T19125	T19124	nummod	42,43
R6081	T19688	T19687	compound	knockout,mice
R6082	T19689	T19674	conj	show,displayed
R6083	T19126	T19124	punct	",",43
R6084	T19127	T19124	punct	],43
R6085	T19690	T19691	det	a,reduction
R6086	T19691	T19689	dobj	reduction,show
R6087	T19128	T19108	punct	", ",is
R6088	T19692	T19691	prep	in,reduction
R6089	T19693	T19692	pobj	size,in
R6090	T19694	T19691	cc	and,reduction
R6091	T19129	T19108	nsubj	it,is
R6092	T19695	T19696	advmod	drastically,reduced
R6093	T19696	T19697	amod	reduced,length
R6094	T19130	T19108	acomp	probable,is
R6095	T19697	T19691	conj	length,reduction
R6096	T19698	T19697	compound	bone,length
R6097	T19699	T19700	punct	[,53
R6098	T19131	T19132	mark	that,reside
R6099	T19700	T19689	parataxis	53,show
R6100	T19701	T19700	punct	],53
R6101	T19702	T19689	punct	.,show
R6102	T19132	T19108	ccomp	reside,is
R6103	T19704	T19705	nsubj	All,are
R6104	T19706	T19704	prep	of,All
R6105	T19133	T19134	det	the,mutation
R6106	T19707	T19708	det	these,genes
R6107	T19708	T19706	pobj	genes,of
R6108	T19134	T19132	nsubj	mutation,reside
R6109	T19709	T19710	amod	excellent,genes
R6110	T19135	T19134	amod	underlying,mutation
R6111	T19136	T19134	prep	in,mutation
R6113	T19137	T19138	det	the,HG11
R6114	T19711	T19710	amod	functional,genes
R6115	T19712	T19711	cc	and,functional
R6116	T19138	T19136	pobj	HG11,in
R6117	T19713	T19711	conj	positional,functional
R6119	T19139	T19138	amod	congenic,HG11
R6123	T19140	T19132	aux	may,reside
R6126	T19141	T19132	prep	in,reside
R6132	T19142	T19143	det	a,gene
R6137	T19143	T19141	pobj	gene,in
R6138	T19144	T19143	acl	enhancing,gene
R6139	T19145	T19146	npadvmod	Gh,induced
R6140	T19146	T19147	amod	induced,effects
R6141	T19147	T19144	dobj	effects,enhancing
R6142	T19148	T19149	npadvmod	sex,specific
R6143	T19149	T19147	amod	specific,effects
R6144	T19150	T19149	punct	-,specific
R6145	T19151	T19108	punct	.,is
R6146	T19153	T19154	det	The,gene
R6147	T19154	T19157	nsubj	gene,are
R6148	T19155	T19154	amod	structural,gene
R6149	T19156	T19154	compound	Gh,gene
R6150	T19158	T19154	appos	itself,gene
R6151	T19159	T19154	cc	and,gene
R6152	T19160	T19154	conj	Stat5b,gene
R6153	T19161	T19162	amod	excellent,candidates
R6154	T19162	T19157	attr	candidates,are
R6155	T19163	T19157	punct	.,are
R6156	T19165	T19166	det	The,role
R6157	T19166	T19168	nsubj	role,include
R6158	T19167	T19166	amod	potential,role
R6159	T19169	T19166	prep	of,role
R6160	T19170	T19169	pobj	Gh,of
R6161	T19171	T19168	aux	would,include
R6162	T19172	T19168	dobj	polymorphism,include
R6163	T19173	T19174	dep	that,alters
R6164	T19174	T19172	advcl	alters,polymorphism
R6165	T19175	T19176	compound	protein,function
R6166	T19176	T19174	dobj	function,alters
R6167	T19177	T19174	prep	in,alters
R6168	T19178	T19179	det	the,absence
R6169	T19179	T19177	pobj	absence,in
R6170	T19180	T19179	prep	of,absence
R6171	T19181	T19180	pobj	Socs2,of
R6172	T19182	T19174	cc	or,alters
R6173	T19183	T19184	dep	that,causes
R6174	T19184	T19174	conj	causes,alters
R6175	T19185	T19186	amod	transcriptional,deregulation
R6176	T19186	T19184	dobj	deregulation,causes
R6177	T19187	T19186	prep	of,deregulation
R6178	T19188	T19187	pobj	Gh,of
R6179	T19189	T19168	punct	.,include
R6180	T19191	T19192	advmod	Additionally,explain
R6181	T19193	T19192	punct	", ",explain
R6182	T19194	T19195	amod	functional,variation
R6183	T19195	T19192	nsubj	variation,explain
R6184	T19196	T19195	prep	in,variation
R6185	T19197	T19196	pobj	Stat5b,in
R6186	T19198	T19192	aux	may,explain
R6187	T19199	T19200	det	the,phenotypes
R6188	T19200	T19192	dobj	phenotypes,explain
R6189	T19896	T19897	det	The,strains
R6190	T19897	T19900	nsubj	strains,confirm
R6191	T19898	T19899	npadvmod	speed,congenic
R6192	T19899	T19897	amod	congenic,strains
R6193	T19901	T19897	acl	developed,strains
R6194	T19902	T19901	advmod	herein,developed
R6195	T19903	T19904	advmod	previously,identified
R6196	T19904	T19905	amod	identified,QTL
R6197	T19905	T19900	dobj	QTL,confirm
R6198	T19906	T19907	npadvmod	genome,wide
R6199	T19907	T19905	amod	wide,QTL
R6200	T19908	T19907	punct	-,wide
R6201	T19909	T19905	acl	affecting,QTL
R6202	T19910	T19909	dobj	growth,affecting
R6203	T19911	T19910	punct	", ",growth
R6204	T19912	T19910	conj	obesity,growth
R6205	T19913	T19912	cc	and,obesity
R6206	T19914	T19915	compound	carcass,composition
R6207	T19915	T19912	conj	composition,obesity
R6208	T19916	T19900	punct	.,confirm
R6209	T19918	T19919	poss	Our,approach
R6210	T19919	T19923	nsubj	approach,provided
R6211	T19920	T19919	amod	novel,approach
R6212	T19921	T19922	amod	congenic,development
R6213	T19922	T19919	compound	development,approach
R6214	T19924	T19919	prep	on,approach
R6215	T19925	T19924	pobj	MMU2,on
R6216	T19926	T19923	dobj	confirmation,provided
R6217	T19927	T19926	prep	of,confirmation
R6218	T19928	T19929	compound	QTL,hg
R6219	T19929	T19931	compound	hg,interactions
R6220	T19930	T19929	punct	-,hg
R6221	T19931	T19927	pobj	interactions,of
R6222	T19932	T19926	punct	", ",confirmation
R6223	T19933	T19934	dep	which,aid
R6224	T19934	T19926	relcl	aid,confirmation
R6225	T19935	T19934	aux	will,aid
R6226	T19936	T19934	advmod	significantly,aid
R6227	T19937	T19934	prep	in,aid
R6228	T19938	T19939	amod	future,experiments
R6229	T19939	T19937	pobj	experiments,in
R6230	T19940	T19941	amod	fine,mapping
R6231	T19941	T19939	compound	mapping,experiments
R6232	T19942	T19923	punct	.,provided
R6233	T19944	T19945	det	The,identification
R6234	T19945	T19946	nsubj	identification,provide
R6235	T19947	T19945	prep	of,identification
R6236	T19948	T19949	det	the,mediators
R6237	T19949	T19947	pobj	mediators,of
R6238	T19950	T19949	amod	molecular,mediators
R6239	T19951	T19949	prep	of,mediators
R6240	T19952	T19953	compound	QTL,hg
R6241	T19953	T19955	compound	hg,epistasis
R6242	T19954	T19953	punct	-,hg
R6243	T19955	T19951	pobj	epistasis,of
R6244	T19956	T19957	advmod	as,as
R6245	T19957	T19949	cc	as,mediators
R6246	T19958	T19957	advmod	well,as
R6247	T19959	T19960	det	the,QTG
R6248	T19960	T19949	conj	QTG,mediators
R6249	T19961	T19960	prep	for,QTG
R6250	T19962	T19963	det	the,congenics
R6251	T19963	T19961	pobj	congenics,for
R6252	T19964	T19963	amod	remaining,congenics
R6253	T19965	T19946	aux	will,provide
R6254	T19966	T19967	amod	essential,information
R6255	T19967	T19946	dobj	information,provide
R6256	T19968	T19967	prep	on,information
R6257	T19969	T19970	det	the,architecture
R6258	T19970	T19968	pobj	architecture,on
R6259	T19971	T19970	amod	molecular,architecture
R6260	T19972	T19970	amod	genetic,architecture
R6261	T19973	T19970	prep	of,architecture
R6262	T19974	T19973	pobj	growth,of
R6263	T19975	T19974	cc	and,growth
R6264	T19976	T19974	conj	obesity,growth
R6265	T19977	T19946	punct	.,provide
R6266	T20228	T20229	compound	Mouse,strains
R6267	T20230	T20229	cc	and,strains
R6268	T20231	T20229	conj	husbandry,strains
R6269	T20233	T20234	nmod	CAST,EiJ
R6270	T20234	T20236	nmod	EiJ,mice
R6271	T20235	T20234	punct	/,EiJ
R6272	T20236	T20242	nsubjpass	mice,purchased
R6273	T20237	T20238	punct	(,#
R6274	T20238	T20236	parataxis	#,mice
R6275	T20239	T20238	compound	stock,#
R6276	T20240	T20238	nummod	000928,#
R6277	T20241	T20238	punct	),#
R6278	T20243	T20242	auxpass	were,purchased
R6279	T20244	T20242	prep	from,purchased
R6280	T20245	T20246	det	the,Laboratory
R6281	T20246	T20244	pobj	Laboratory,from
R6282	T20247	T20246	compound	Jackson,Laboratory
R6283	T20248	T20242	punct	.,purchased
R6284	T20250	T20251	det	The,mutation
R6285	T20251	T20253	nsubjpass	mutation,identified
R6286	T20252	T20251	compound	hg,mutation
R6287	T20254	T20253	auxpass	was,identified
R6288	T20255	T20253	advmod	originally,identified
R6289	T20256	T20253	prep	in,identified
R6290	T20257	T20258	det	a,line
R6291	T20258	T20256	pobj	line,in
R6292	T20259	T20258	amod	selected,line
R6293	T20260	T20258	compound	outcross,line
R6294	T20261	T20262	punct	[,22
R6295	T20262	T20253	parataxis	22,identified
R6296	T20263	T20262	punct	],22
R6297	T20264	T20253	cc	and,identified
R6298	T20265	T20266	aux	has,introgressed
R6299	T20266	T20253	conj	introgressed,identified
R6300	T20267	T20266	auxpass	been,introgressed
R6301	T20268	T20266	prep	onto,introgressed
R6302	T20269	T20270	det	a,background
R6303	T20270	T20268	pobj	background,onto
R6304	T20271	T20270	compound	B6,background
R6305	T20272	T20266	prep	via,introgressed
R6306	T20273	T20274	nummod	nine,backcrosses
R6307	T20274	T20272	pobj	backcrosses,via
R6308	T20275	T20276	aux	to,create
R6309	T20276	T20266	advcl	create,introgressed
R6310	T20277	T20278	det	the,strain
R6311	T20278	T20276	dobj	strain,create
R6312	T20279	T20278	compound	HG,strain
R6313	T20280	T20253	punct	.,identified
R6314	T20282	T20283	compound	HG,mice
R6315	T20283	T20284	nsubj	mice,were
R6316	T20285	T20283	acl	used,mice
R6317	T20286	T20285	prep	in,used
R6318	T20287	T20288	det	this,experiment
R6319	T20288	T20286	pobj	experiment,in
R6320	T20289	T20284	prep	from,were
R6321	T20290	T20291	det	the,generation
R6322	T20291	T20289	pobj	generation,from
R6323	T20292	T20291	amod	17th,generation
R6324	T20293	T20292	cc	or,17th
R6325	T20294	T20292	conj	later,17th
R6326	T20295	T20291	prep	of,generation
R6327	T20296	T20295	pobj	inbreeding,of
R6328	T20297	T20284	punct	.,were
R6329	T20299	T20300	nsubjpass	Mice,housed
R6330	T20301	T20300	auxpass	were,housed
R6331	T20302	T20300	prep	in,housed
R6332	T20303	T20304	compound	polycarbonate,cages
R6333	T20304	T20302	pobj	cages,in
R6334	T20305	T20300	prep	under,housed
R6335	T20306	T20307	amod	controlled,conditions
R6336	T20307	T20305	pobj	conditions,under
R6337	T20308	T20307	prep	of,conditions
R6338	T20309	T20308	pobj	temperature,of
R6339	T20310	T20311	punct	(,°C
R6340	T20311	T20309	parataxis	°C,temperature
R6341	T20312	T20311	nummod	21,°C
R6342	T20313	T20311	punct	±,°C
R6343	T20314	T20315	nummod	2,°C
R6344	T20315	T20311	appos	°C,°C
R6345	T20316	T20311	punct	),°C
R6346	T20317	T20309	punct	", ",temperature
R6347	T20318	T20309	conj	humidity,temperature
R6348	T20319	T20320	punct	(,%
R6349	T20320	T20318	parataxis	%,humidity
R6350	T20321	T20322	quantmod	40,70
R6351	T20322	T20320	nummod	70,%
R6352	T20323	T20322	punct	–,70
R6353	T20324	T20320	punct	),%
R6354	T20325	T20318	cc	and,humidity
R6355	T20326	T20318	conj	lighting,humidity
R6356	T20327	T20328	punct	(,dark
R6357	T20328	T20326	parataxis	dark,lighting
R6358	T20329	T20330	nummod	14,h
R6359	T20330	T20331	compound	h,light
R6360	T20331	T20328	dep	light,dark
R6361	T20332	T20328	punct	", ",dark
R6362	T20333	T20334	nummod	10,h
R6363	T20334	T20328	compound	h,dark
R6364	T20335	T20328	punct	", ",dark
R6365	T20336	T20337	nsubj	lights,on
R6366	T20337	T20328	advmod	on,dark
R6367	T20338	T20337	prep	at,on
R6368	T20339	T20340	nummod	7,AM
R6369	T20340	T20338	pobj	AM,at
R6370	T20341	T20328	punct	),dark
R6371	T20342	T20300	punct	", ",housed
R6372	T20343	T20300	cc	and,housed
R6373	T20344	T20300	conj	managed,housed
R6374	T20345	T20344	prep	according,managed
R6375	T20346	T20345	prep	to,according
R6376	T20347	T20348	det	the,guidelines
R6377	T20348	T20346	pobj	guidelines,to
R6378	T20349	T20348	prep	of,guidelines
R6379	T20350	T20351	det	the,Association
R6380	T20351	T20349	pobj	Association,of
R6381	T20352	T20351	compound	American,Association
R6382	T20353	T20351	prep	for,Association
R6383	T20354	T20353	pobj	Accreditation,for
R6384	T20355	T20354	prep	of,Accreditation
R6385	T20356	T20357	compound	Laboratory,Animal
R6386	T20357	T20358	compound	Animal,Care
R6387	T20358	T20355	pobj	Care,of
R6388	T20359	T20351	punct	(,Association
R6389	T20360	T20351	appos	AAALAC,Association
R6390	T20361	T20300	punct	),housed
R6391	T20362	T20300	punct	.,housed
R6392	T20781	T20782	nsubjpass	DNA,isolated
R6393	T20783	T20781	prep	for,DNA
R6394	T20784	T20783	pobj	genotyping,for
R6395	T20785	T20782	auxpass	was,isolated
R6396	T20786	T20782	prep	from,isolated
R6397	T20787	T20788	quantmod	1.0,2.0
R6398	T20788	T20790	nummod	2.0,mm
R6399	T20789	T20788	punct	–,2.0
R6400	T20790	T20791	compound	mm,clips
R6401	T20791	T20786	pobj	clips,from
R6402	T20792	T20791	compound	tail,clips
R6403	T20793	T20782	prep	by,isolated
R6404	T20794	T20793	pcomp	digesting,by
R6405	T20795	T20794	prep	with,digesting
R6406	T20796	T20797	compound	Proteinase,K
R6407	T20797	T20795	pobj	K,with
R6408	T20798	T20799	punct	(,Fisher
R6409	T20799	T20797	parataxis	Fisher,K
R6410	T20800	T20799	punct	),Fisher
R6411	T20801	T20794	prep	at,digesting
R6412	T20802	T20803	nummod	55,°C
R6413	T20803	T20801	pobj	°C,at
R6414	T20804	T20794	prep	in,digesting
R6415	T20805	T20806	det	a,buffer
R6416	T20806	T20804	pobj	buffer,in
R6417	T20807	T20806	acl	composed,buffer
R6418	T20808	T20807	prep	of,composed
R6419	T20809	T20810	nummod	0.45,%
R6420	T20810	T20811	compound	%,NP40
R6421	T20811	T20808	pobj	NP40,of
R6422	T20812	T20813	punct	(,Sigma
R6423	T20813	T20811	parataxis	Sigma,NP40
R6424	T20814	T20813	punct	),Sigma
R6425	T20815	T20811	punct	", ",NP40
R6426	T20816	T20817	nummod	0.45,%
R6427	T20817	T20818	compound	%,Tween
R6428	T20818	T20811	conj	Tween,NP40
R6429	T20819	T20818	nummod	20,Tween
R6430	T20820	T20821	punct	(,Fisher
R6431	T20821	T20818	parataxis	Fisher,Tween
R6432	T20822	T20821	punct	),Fisher
R6433	T20823	T20818	cc	and,Tween
R6434	T20824	T20825	compound	1X,buffer
R6435	T20825	T20818	conj	buffer,Tween
R6436	T20826	T20825	compound	PCR,buffer
R6437	T20827	T20828	punct	(,Promega
R6438	T20828	T20825	parataxis	Promega,buffer
R6439	T20829	T20828	punct	),Promega
R6440	T20830	T20782	punct	.,isolated
R6441	T20832	T20833	det	The,product
R6442	T20833	T20834	nsubjpass	product,diluted
R6443	T20835	T20833	prep	of,product
R6444	T20836	T20837	det	this,digestion
R6445	T20837	T20835	pobj	digestion,of
R6446	T20838	T20834	auxpass	was,diluted
R6447	T20839	T20840	punct	(,1
R6448	T20840	T20834	parataxis	1,diluted
R6449	T20841	T20842	punct	:,10
R6450	T20842	T20840	prep	10,1
R6451	T20843	T20840	punct	),1
R6452	T20844	T20834	prep	in,diluted
R6453	T20845	T20846	amod	sterile,H2O
R6454	T20846	T20844	pobj	H2O,in
R6455	T20847	T20834	cc	and,diluted
R6456	T20848	T20834	conj	used,diluted
R6457	T20849	T20848	prep	for,used
R6458	T20850	T20849	pobj	genotyping,for
R6459	T20851	T20848	prep	without,used
R6460	T20852	T20853	amod	further,purification
R6461	T20853	T20851	pobj	purification,without
R6462	T20854	T20834	punct	.,diluted
R6463	T20856	T20857	compound	Microsatellite,genotyping
R6464	T20857	T20858	nsubjpass	genotyping,performed
R6465	T20859	T20858	auxpass	was,performed
R6466	T20860	T20858	advcl	using,performed
R6467	T20861	T20862	amod	standard,protocols
R6468	T20862	T20860	dobj	protocols,using
R6469	T20863	T20862	nmod	PCR,protocols
R6470	T20864	T20863	cc	and,PCR
R6471	T20865	T20866	compound	gel,electrophoresis
R6472	T20866	T20863	conj	electrophoresis,PCR
R6473	T20867	T20858	punct	.,performed
R6474	T20869	T20870	compound	Reaction,conditions
R6475	T20870	T20871	nsubjpass	conditions,listed
R6476	T20872	T20870	prep	for,conditions
R6477	T20873	T20874	det	each,marker
R6478	T20874	T20872	pobj	marker,for
R6479	T20875	T20871	auxpass	are,listed
R6480	T20876	T20871	prep	in,listed
R6481	T20877	T20878	amod	Additional,1
R6482	T20878	T20876	pobj	1,in
R6483	T20879	T20878	nmod	File,1
R6484	T20880	T20878	cc	and,1
R6485	T20881	T20878	conj	2,1
R6486	T20882	T20871	punct	.,listed
R6487	T20884	T20885	npadvmod	MMU2,congenic
R6488	T20885	T20886	amod	congenic,mice
R6489	T20886	T20887	nsubjpass	mice,genotyped
R6490	T20888	T20887	auxpass	were,genotyped
R6491	T20889	T20887	prep	for,genotyped
R6492	T20890	T20889	pobj	hg,for
R6493	T20891	T20887	advcl	using,genotyped
R6494	T20892	T20893	det	a,assay
R6495	T20893	T20891	dobj	assay,using
R6496	T20894	T20895	nummod	two,primer
R6497	T20895	T20893	compound	primer,assay
R6498	T20896	T20893	compound	genotyping,assay
R6499	T20897	T20887	punct	.,genotyped
R6500	T20899	T20900	nummod	One,set
R6501	T20900	T20902	nsubj	set,spanned
R6502	T20901	T20900	compound	primer,set
R6503	T20903	T20900	punct	(,set
R6504	T20904	T20905	compound	HG,F
R6505	T20905	T20900	appos	F,set
R6506	T20906	T20905	punct	-,F
R6507	T20907	T20905	punct	", ",F
R6508	T20908	T20905	appos	ctcctgtctgggctgtgag,F
R6509	T20909	T20905	cc	and,F
R6510	T20910	T20911	compound	HG,R
R6511	T20911	T20905	conj	R,F
R6512	T20912	T20911	punct	-,R
R6513	T20913	T20911	punct	", ",R
R6514	T20914	T20911	appos	caaaggcagaagtggggtaa,R
R6515	T20915	T20902	punct	),spanned
R6516	T20916	T20917	det	the,deletion
R6517	T20917	T20902	dobj	deletion,spanned
R6518	T20918	T20917	compound	hg,deletion
R6519	T20919	T20902	advcl	producing,spanned
R6520	T20920	T20921	det	a,product
R6521	T20921	T20919	dobj	product,producing
R6522	T20922	T20923	nummod	447,bp
R6523	T20923	T20921	compound	bp,product
R6524	T20924	T20919	prep	in,producing
R6525	T20925	T20926	nmod	hg,hg
R6526	T20926	T20928	nmod	hg,mice
R6527	T20927	T20926	punct	/,hg
R6528	T20928	T20924	pobj	mice,in
R6529	T20929	T20926	cc	and,hg
R6530	T20930	T20931	punct	+,hg
R6531	T20931	T20926	conj	hg,hg
R6532	T20932	T20931	punct	/,hg
R6533	T20933	T20902	punct	.,spanned
R6534	T20935	T20936	det	The,set
R6535	T20936	T20938	nsubj	set,amplified
R6536	T20937	T20936	amod	other,set
R6537	T20939	T20936	punct	(,set
R6538	T20940	T20936	appos	CRADD3a.F,set
R6539	T20941	T20940	punct	", ",CRADD3a.F
R6540	T20942	T20940	appos	gtccatcagcattcctgaaa,CRADD3a.F
R6541	T20943	T20940	cc	and,CRADD3a.F
R6542	T20944	T20940	conj	CRADD3.R,CRADD3a.F
R6543	T20945	T20944	punct	", ",CRADD3.R
R6544	T20946	T20944	appos	tgtccagcaacagcattgtc,CRADD3.R
R6545	T20947	T20938	punct	),amplified
R6546	T20948	T20949	det	a,amplicon
R6547	T20949	T20938	dobj	amplicon,amplified
R6548	T20950	T20951	nummod	232,bp
R6549	T20951	T20949	compound	bp,amplicon
R6550	T20952	T20949	compound	Cradd,amplicon
R6551	T20953	T20949	punct	(,amplicon
R6552	T20954	T20949	acl	located,amplicon
R6553	T20955	T20954	prep	within,located
R6554	T20956	T20957	det	the,deletion
R6555	T20957	T20955	pobj	deletion,within
R6556	T20958	T20957	compound	hg,deletion
R6557	T20959	T20938	punct	),amplified
R6558	T20960	T20938	prep	in,amplified
R6559	T20961	T20962	punct	+,+
R6560	T20962	T20964	punct	+,mice
R6561	T20963	T20962	punct	/,+
R6562	T20964	T20960	pobj	mice,in
R6563	T20965	T20962	cc	and,+
R6564	T20966	T20967	punct	+,hg
R6565	T20967	T20962	conj	hg,+
R6566	T20968	T20967	punct	/,hg
R6567	T20969	T20970	punct	[,54
R6568	T20970	T20938	parataxis	54,amplified
R6569	T20971	T20970	punct	],54
R6570	T20972	T20938	punct	.,amplified
R6571	T20974	T20975	det	The,temperature
R6572	T20975	T20978	nsubj	temperature,was
R6573	T20976	T20977	npadvmod	PCR,annealing
R6574	T20977	T20975	amod	annealing,temperature
R6575	T20979	T20980	nummod	55,°C
R6576	T20980	T20978	attr	°C,was
R6577	T20981	T20978	cc	and,was
R6578	T20982	T20983	det	the,concentration
R6579	T20983	T20985	nsubj	concentration,was
R6580	T20984	T20983	compound	MgCl2,concentration
R6581	T20985	T20978	conj	was,was
R6582	T20986	T20987	nummod	1.5,mM
R6583	T20987	T20985	attr	mM,was
R6584	T20988	T20985	punct	.,was
R6585	T21608	T21607	prep	of,Development
R6586	T21609	T21610	nmod	B6.CAST,MMU2
R6587	T21610	T21613	nmod	MMU2,strains
R6588	T21611	T21609	cc	and,B6.CAST
R6589	T21612	T21609	conj	HG.CAST,B6.CAST
R6590	T21613	T21608	pobj	strains,of
R6591	T21614	T21615	npadvmod	speed,congenic
R6592	T21615	T21613	amod	congenic,strains
R6593	T21617	T21618	det	All,strains
R6594	T21618	T21621	nsubjpass	strains,developed
R6595	T21619	T21620	npadvmod	speed,congenic
R6596	T21620	T21618	amod	congenic,strains
R6597	T21622	T21621	auxpass	were,developed
R6598	T21623	T21621	advcl	starting,developed
R6599	T21624	T21623	prep	with,starting
R6600	T21625	T21626	det	an,cross
R6601	T21626	T21624	pobj	cross,with
R6602	T21627	T21626	amod	initial,cross
R6603	T21628	T21626	prep	between,cross
R6604	T21629	T21630	det	a,male
R6605	T21630	T21628	pobj	male,between
R6606	T21631	T21630	compound	CAST,male
R6607	T21632	T21630	cc	and,male
R6608	T21633	T21634	compound	HG,females
R6609	T21634	T21630	conj	females,male
R6610	T21635	T21636	punct	(,Figure
R6611	T21636	T21623	parataxis	Figure,starting
R6612	T21637	T21636	nummod	1,Figure
R6613	T21638	T21636	punct	),Figure
R6614	T21639	T21640	punct	[,6
R6615	T21640	T21621	parataxis	6,developed
R6616	T21641	T21640	nummod	5,6
R6617	T21642	T21640	punct	",",6
R6618	T21643	T21640	punct	],6
R6619	T21644	T21621	punct	.,developed
R6620	T21646	T21647	amod	Male,mice
R6621	T21647	T21649	nsubjpass	mice,backcrossed
R6622	T21648	T21647	compound	F1,mice
R6623	T21650	T21649	auxpass	were,backcrossed
R6624	T21651	T21649	advmod	then,backcrossed
R6625	T21652	T21649	prep	to,backcrossed
R6626	T21653	T21654	compound	HG,females
R6627	T21654	T21652	pobj	females,to
R6628	T21655	T21649	punct	.,backcrossed
R6629	T21657	T21658	det	All,males
R6631	T21659	T21658	nmod	agouti,males
R6632	T21660	T21661	punct	(,located
R6633	T21661	T21658	parataxis	located,males
R6634	T21662	T21663	det	the,locus
R6635	T21663	T21661	nsubjpass	locus,located
R6636	T21664	T21663	amod	dominant,locus
R6637	T21665	T21666	amod	nonagouti,a
R6638	T21666	T21663	amod	a,locus
R6639	T21667	T21666	punct	(,a
R6640	T21668	T21663	punct	),locus
R6641	T21669	T21661	auxpass	is,located
R6642	T21670	T21661	prep	at,located
R6643	T21671	T21672	nummod	154.8,Mbp
R6644	T21672	T21670	pobj	Mbp,at
R6645	T21673	T21661	prep	on,located
R6646	T21674	T21673	pobj	MMU2,on
R6647	T21675	T21661	punct	),located
R6648	T21676	T21658	compound	N2,males
R6649	T21678	T21677	auxpass	were,genotyped
R6650	T21679	T21677	prep	for,genotyped
R6651	T21680	T21681	nummod	79,markers
R6652	T21681	T21679	pobj	markers,for
R6653	T21682	T21681	compound	microsatellite,markers
R6654	T21683	T21684	punct	(,File
R6655	T21684	T21677	parataxis	File,genotyped
R6656	T21685	T21684	amod	Additional,File
R6657	T21686	T21684	nummod	1,File
R6658	T21687	T21684	punct	),File
R6659	T21688	T21677	punct	.,genotyped
R6660	T21690	T21691	det	These,markers
R6661	T21691	T21692	nsubjpass	markers,spaced
R6662	T21693	T21692	auxpass	were,spaced
R6663	T21694	T21692	advmod	evenly,spaced
R6664	T21695	T21692	prep	across,spaced
R6665	T21696	T21697	det	the,genome
R6666	T21697	T21695	pobj	genome,across
R6667	T21698	T21692	punct	", ",spaced
R6668	T21699	T21700	advmod	except,in
R6669	T21700	T21692	prep	in,spaced
R6670	T21701	T21700	pobj	regions,in
R6671	T21702	T21703	advmod	previously,identified
R6672	T21703	T21701	acl	identified,regions
R6673	T21704	T21703	prep	as,identified
R6674	T21705	T21704	pcomp	harboring,as
R6675	T21706	T21705	dobj	QTL,harboring
R6676	T21707	T21708	punct	[,1
R6677	T21708	T21705	parataxis	1,harboring
R6678	T21709	T21708	punct	],1
R6679	T21710	T21701	punct	", ",regions
R6680	T21711	T21712	dep	which,screened
R6681	T21712	T21701	relcl	screened,regions
R6682	T21713	T21712	auxpass	were,screened
R6683	T21714	T21715	advmod	more,densely
R6684	T21715	T21712	advmod	densely,screened
R6685	T21716	T21692	punct	.,spaced
R6686	T21718	T21719	det	The,male
R6687	T21719	T21725	nsubjpass	male,selected
R6688	T21720	T21719	punct	"""",male
R6689	T21721	T21719	amod	best,male
R6690	T21722	T21719	punct	"""",male
R6691	T21723	T21724	compound	N2,agouti
R6692	T21724	T21719	compound	agouti,male
R6693	T21726	T21719	prep	with,male
R6694	T21727	T21728	det	the,level
R6695	T21728	T21726	pobj	level,with
R6696	T21729	T21728	amod	lowest,level
R6697	T21730	T21728	prep	of,level
R6698	T21731	T21732	npadvmod	genome,wide
R6699	T21732	T21734	amod	wide,heterozygosity
R6700	T21733	T21732	punct	-,wide
R6701	T21734	T21730	pobj	heterozygosity,of
R6702	T21735	T21734	amod	unwanted,heterozygosity
R6703	T21736	T21737	mark	while,maintaining
R6704	T21737	T21725	advcl	maintaining,selected
R6705	T21738	T21739	compound	CAST,alleles
R6706	T21739	T21737	dobj	alleles,maintaining
R6707	T21740	T21739	prep	for,alleles
R6708	T21741	T21742	det	all,markers
R6709	T21742	T21740	pobj	markers,for
R6710	T21743	T21742	compound	MMU2,markers
R6711	T21744	T21725	auxpass	was,selected
R6712	T21745	T21725	prep	for,selected
R6713	T21746	T21745	pobj	breeding,for
R6714	T21747	T21725	punct	.,selected
R6715	T21749	T21750	det	This,scheme
R6716	T21750	T21752	nsubjpass	scheme,used
R6717	T21751	T21750	compound	selection,scheme
R6718	T21753	T21752	auxpass	was,used
R6719	T21754	T21752	prep	at,used
R6720	T21755	T21756	det	each,generation
R6721	T21756	T21754	pobj	generation,at
R6722	T21757	T21758	mark	until,identified
R6723	T21758	T21752	advcl	identified,used
R6724	T21759	T21760	det	a,male
R6725	T21760	T21758	nsubjpass	male,identified
R6726	T21761	T21760	compound	N4,male
R6727	T21762	T21758	auxpass	was,identified
R6728	T21763	T21758	prep	as,identified
R6729	T21764	T21765	amod	homozygous,HG
R6730	T21765	T21763	pobj	HG,as
R6731	T21766	T21765	prep	for,HG
R6732	T21767	T21768	det	all,markers
R6733	T21768	T21766	pobj	markers,for
R6734	T21769	T21768	acl	typed,markers
R6735	T21770	T21769	prep	outside,typed
R6736	T21771	T21770	pobj	MMU2,outside
R6737	T21772	T21752	punct	.,used
R6738	T21774	T21775	prep	After,identified
R6739	T21776	T21777	det	an,backcross
R6740	T21777	T21774	pobj	backcross,After
R6741	T21778	T21777	amod	additional,backcross
R6742	T21779	T21777	prep	to,backcross
R6743	T21780	T21781	compound	HG,females
R6744	T21781	T21779	pobj	females,to
R6745	T21782	T21775	punct	", ",identified
R6746	T21783	T21784	amod	recombinant,males
R6747	T21784	T21775	nsubjpass	males,identified
R6748	T21785	T21775	auxpass	were,identified
R6749	T21786	T21775	advcl	providing,identified
R6750	T21787	T21788	det	the,foundation
R6751	T21788	T21786	dobj	foundation,providing
R6752	T21789	T21788	prep	for,foundation
R6753	T21790	T21791	det	the,regions
R6754	T21791	T21789	pobj	regions,for
R6755	T21792	T21791	nummod	four,regions
R6756	T21793	T21791	amod	overlapping,regions
R6757	T21794	T21791	compound	donor,regions
R6758	T21795	T21775	punct	.,identified
R6759	T21797	T21798	amod	Selected,males
R6760	T21798	T21800	nsubjpass	males,backcrossed
R6761	T21799	T21798	amod	recombinant,males
R6762	T21801	T21800	auxpass	were,backcrossed
R6763	T21802	T21800	advmod	then,backcrossed
R6764	T21803	T21800	prep	to,backcrossed
R6765	T21804	T21805	preconj	both,B6
R6766	T21805	T21806	nmod	B6,females
R6767	T21806	T21803	pobj	females,to
R6768	T21807	T21805	cc	and,B6
R6769	T21808	T21805	conj	HG,B6
R6770	T21809	T21810	aux	to,create
R6771	T21810	T21800	advcl	create,backcrossed
R6772	T21811	T21810	dobj	strains,create
R6773	T21812	T21811	punct	", ",strains
R6774	T21813	T21814	dep	which,were
R6775	T21814	T21811	relcl	were,strains
R6776	T21815	T21816	npadvmod	B6,congenic
R6777	T21816	T21814	acomp	congenic,were
R6778	T21817	T21818	punct	(,+
R6779	T21818	T21815	punct	+,B6
R6780	T21819	T21818	punct	+,+
R6781	T21820	T21818	punct	/,+
R6782	T21821	T21818	punct	),+
R6783	T21822	T21815	cc	or,B6
R6784	T21823	T21815	conj	HG,B6
R6785	T21824	T21825	punct	(,hg
R6786	T21825	T21823	parataxis	hg,HG
R6787	T21826	T21825	compound	hg,hg
R6788	T21827	T21825	punct	/,hg
R6789	T21828	T21825	punct	),hg
R6790	T21829	T21815	cc	and,B6
R6791	T21830	T21815	conj	heterozygous,B6
R6792	T21831	T21800	punct	.,backcrossed
R6793	T21833	T21834	det	These,mice
R6794	T21834	T21835	nsubjpass	mice,intermated
R6795	T21836	T21835	auxpass	were,intermated
R6796	T21837	T21838	aux	to,produce
R6797	T21838	T21835	advcl	produce,intermated
R6798	T21839	T21840	amod	homozygous,founders
R6799	T21840	T21838	dobj	founders,produce
R6800	T21841	T21838	prep	for,produce
R6801	T21842	T21843	det	each,strain
R6802	T21843	T21841	pobj	strain,for
R6803	T21844	T21835	punct	.,intermated
R6804	T21846	T21847	det	This,scheme
R6805	T21847	T21850	nsubj	scheme,created
R6806	T21848	T21847	amod	novel,scheme
R6807	T21849	T21847	amod	breeding,scheme
R6808	T21851	T21852	nummod	four,congenics
R6809	T21852	T21850	dobj	congenics,created
R6810	T21853	T21852	amod	identical,congenics
R6811	T21854	T21852	compound	founder,congenics
R6812	T21855	T21852	prep	on,congenics
R6813	T21856	T21857	nummod	two,backgrounds
R6814	T21857	T21855	pobj	backgrounds,on
R6815	T21858	T21857	appos	B6,backgrounds
R6816	T21859	T21860	punct	(,+
R6817	T21860	T21858	punct	+,B6
R6818	T21861	T21860	punct	+,+
R6819	T21862	T21860	punct	/,+
R6820	T21863	T21860	punct	),+
R6821	T21864	T21858	cc	and,B6
R6822	T21865	T21858	conj	HG,B6
R6823	T21866	T21867	punct	(,hg
R6824	T21867	T21865	parataxis	hg,HG
R6825	T21868	T21867	compound	hg,hg
R6826	T21869	T21867	punct	/,hg
R6827	T21870	T21867	punct	),hg
R6828	T21871	T21857	punct	", ",backgrounds
R6829	T21872	T21873	dep	which,formed
R6830	T21873	T21857	relcl	formed,backgrounds
R6831	T21874	T21875	det	the,basis
R6832	T21875	T21873	dobj	basis,formed
R6833	T21876	T21875	prep	for,basis
R6834	T21877	T21878	poss	our,examination
R6835	T21878	T21876	pobj	examination,for
R6836	T21879	T21878	prep	of,examination
R6837	T21880	T21879	pobj	interactions,of
R6838	T21881	T21880	acl	caused,interactions
R6839	T21882	T21881	agent	by,caused
R6840	T21883	T21884	det	the,presence
R6841	T21884	T21882	pobj	presence,by
R6842	T21885	T21884	prep	of,presence
R6843	T21886	T21887	det	the,deletion
R6844	T21887	T21885	pobj	deletion,of
R6845	T21888	T21887	compound	hg,deletion
R6846	T21889	T21850	punct	.,created
R6847	T21891	T21892	nmod	MMU2,strains
R6848	T21892	T21895	nsubjpass	strains,maintained
R6849	T21893	T21894	npadvmod	speed,congenic
R6850	T21894	T21892	amod	congenic,strains
R6851	T21896	T21895	auxpass	were,maintained
R6852	T21897	T21895	prep	through,maintained
R6853	T21898	T21899	compound	brother,sister
R6854	T21899	T21901	compound	sister,mating
R6855	T21900	T21899	punct	-,sister
R6856	T21901	T21897	pobj	mating,through
R6857	T21902	T21895	punct	.,maintained
R6858	T21904	T21905	advmod	Once,stabilized
R6859	T21905	T21909	advcl	stabilized,used
R6860	T21906	T21907	det	each,congenic
R6861	T21907	T21905	nsubjpass	congenic,stabilized
R6862	T21908	T21905	auxpass	was,stabilized
R6863	T21910	T21909	punct	", ",used
R6864	T21911	T21912	nummod	20,markers
R6865	T21912	T21909	nsubjpass	markers,used
R6866	T21913	T21912	amod	additional,markers
R6867	T21914	T21912	compound	microsatellite,markers
R6868	T21915	T21909	auxpass	were,used
R6869	T21916	T21917	aux	to,refine
R6870	T21917	T21909	advcl	refine,used
R6871	T21918	T21919	det	the,position
R6872	T21919	T21917	dobj	position,refine
R6873	T21920	T21919	prep	of,position
R6874	T21921	T21922	det	each,point
R6875	T21922	T21920	pobj	point,of
R6876	T21923	T21922	amod	congenic,point
R6877	T21924	T21922	amod	recombinant,point
R6878	T21925	T21922	compound	end,point
R6879	T21926	T21927	punct	(,File
R6880	T21927	T21909	parataxis	File,used
R6881	T21928	T21927	amod	Additional,File
R6882	T21929	T21927	nummod	2,File
R6883	T21930	T21927	punct	),File
R6884	T21931	T21909	punct	.,used
R6885	T22599	T22598	prep	of,Development
R6886	T22600	T22601	nmod	HG.CAST,strains
R6887	T22601	T22599	pobj	strains,of
R6888	T22602	T22603	npadvmod	speed,congenic
R6889	T22603	T22601	amod	congenic,strains
R6890	T22604	T22601	prep	for,strains
R6891	T22605	T22606	nmod	MMU,1
R6892	T22606	T22604	pobj	1,for
R6893	T22607	T22606	punct	", ",1
R6894	T22608	T22606	conj	5,1
R6895	T22609	T22608	punct	", ",5
R6896	T22610	T22608	conj	8,5
R6897	T22611	T22610	punct	", ",8
R6898	T22612	T22610	conj	9,8
R6899	T22613	T22612	punct	", ",9
R6900	T22614	T22612	conj	11,9
R6901	T22615	T22614	cc	and,11
R6902	T22616	T22614	conj	17,11
R6903	T22618	T22619	det	All,males
R6904	T22619	T22622	nsubjpass	males,genotyped
R6905	T22620	T22619	amod	black,males
R6906	T22621	T22619	compound	N2,males
R6907	T22623	T22619	prep	from,males
R6908	T22624	T22625	det	the,crosses
R6909	T22625	T22623	pobj	crosses,from
R6910	T22626	T22625	amod	first,crosses
R6911	T22627	T22625	nummod	two,crosses
R6912	T22628	T22625	acl	described,crosses
R6913	T22629	T22628	advmod	above,described
R6914	T22630	T22622	auxpass	were,genotyped
R6915	T22631	T22622	prep	for,genotyped
R6916	T22632	T22633	nummod	12,markers
R6917	T22633	T22631	pobj	markers,for
R6918	T22634	T22633	punct	(,markers
R6919	T22635	T22633	appos	D1Mit432,markers
R6920	T22636	T22635	punct	", ",D1Mit432
R6921	T22637	T22638	punct	-,480
R6922	T22638	T22635	conj	480,D1Mit432
R6923	T22639	T22638	punct	", ",480
R6924	T22640	T22638	conj	D5Mit353,480
R6925	T22641	T22640	punct	", ",D5Mit353
R6926	T22642	T22643	punct	-,311
R6927	T22643	T22640	conj	311,D5Mit353
R6928	T22644	T22643	punct	", ",311
R6929	T22645	T22643	conj	D9Mit60,311
R6930	T22646	T22645	punct	", ",D9Mit60
R6931	T22647	T22648	punct	-,262
R6932	T22648	T22645	conj	262,D9Mit60
R6933	T22649	T22648	punct	", ",262
R6934	T22650	T22648	conj	D11Mit5,262
R6935	T22651	T22650	punct	", ",D11Mit5
R6936	T22652	T22653	punct	-,67
R6937	T22653	T22650	conj	67,D11Mit5
R6938	T22654	T22653	punct	", ",67
R6939	T22655	T22653	conj	D8Mit234,67
R6940	T22656	T22655	punct	", ",D8Mit234
R6941	T22657	T22658	punct	-,211
R6942	T22658	T22655	conj	211,D8Mit234
R6943	T22659	T22658	cc	and,211
R6944	T22660	T22658	conj	D17Mit28,211
R6945	T22661	T22660	cc	and,D17Mit28
R6946	T22662	T22663	punct	-,142
R6947	T22663	T22660	conj	142,D17Mit28
R6948	T22664	T22633	punct	),markers
R6949	T22665	T22633	punct	", ",markers
R6950	T22666	T22633	appos	two,markers
R6951	T22667	T22666	acl	spanning,two
R6952	T22668	T22667	dobj	each,spanning
R6953	T22669	T22668	prep	of,each
R6954	T22670	T22671	det	the,regions
R6955	T22671	T22669	pobj	regions,of
R6956	T22672	T22671	nummod	six,regions
R6957	T22673	T22674	npadvmod	QTL,harboring
R6958	T22674	T22671	amod	harboring,regions
R6959	T22675	T22671	punct	(,regions
R6960	T22676	T22677	nmod	MMU,1
R6961	T22677	T22671	appos	1,regions
R6962	T22678	T22677	punct	", ",1
R6963	T22679	T22677	conj	5,1
R6964	T22680	T22679	punct	", ",5
R6965	T22681	T22679	conj	8,5
R6966	T22682	T22681	punct	", ",8
R6967	T22683	T22681	conj	9,8
R6968	T22684	T22683	punct	", ",9
R6969	T22685	T22683	conj	11,9
R6970	T22686	T22685	cc	and,11
R6971	T22687	T22685	conj	17,11
R6972	T22688	T22689	punct	;,Table
R6973	T22689	T22622	parataxis	Table,genotyped
R6974	T22690	T22689	nummod	1,Table
R6975	T22691	T22689	cc	and,Table
R6976	T22692	T22693	amod	Additional,File
R6977	T22693	T22689	conj	File,Table
R6978	T22694	T22693	nummod	1,File
R6979	T22695	T22689	punct	),Table
R6980	T22696	T22622	punct	.,genotyped
R6981	T22698	T22699	nsubjpass	Markers,selected
R6982	T22700	T22699	auxpass	were,selected
R6983	T22701	T22702	aux	to,capture
R6984	T22702	T22699	advcl	capture,selected
R6985	T22703	T22702	punct	", ",capture
R6986	T22704	T22702	prep	at,capture
R6987	T22705	T22706	det	a,minimum
R6988	T22706	T22704	pobj	minimum,at
R6989	T22707	T22702	punct	", ",capture
R6990	T22708	T22709	det	the,interval
R6991	T22709	T22702	dobj	interval,capture
R6992	T22710	T22711	nummod	2,LOD
R6993	T22711	T22709	compound	LOD,interval
R6994	T22712	T22711	punct	-,LOD
R6995	T22713	T22709	compound	support,interval
R6996	T22714	T22699	punct	.,selected
R6997	T22716	T22717	nummod	Two,males
R6998	T22717	T22719	nsubjpass	males,selected
R6999	T22718	T22717	compound	N2,males
R7000	T22720	T22719	auxpass	were,selected
R7001	T22721	T22722	aux	to,propagate
R7002	T22722	T22719	xcomp	propagate,selected
R7003	T22723	T22724	det	the,generation
R7004	T22724	T22722	dobj	generation,propagate
R7005	T22725	T22724	compound	N3,generation
R7006	T22726	T22719	punct	;,selected
R7007	T22727	T22719	dobj	one,selected
R7008	T22728	T22727	amod	heterozygous,one
R7009	T22729	T22728	prep	for,heterozygous
R7010	T22730	T22729	pobj	QTL,for
R7011	T22731	T22730	prep	on,QTL
R7012	T22732	T22733	nmod	MMU,1
R7013	T22733	T22731	pobj	1,on
R7014	T22734	T22733	cc	and,1
R7015	T22735	T22733	conj	9,1
R7016	T22736	T22727	cc	and,one
R7017	T22737	T22738	det	the,other
R7018	T22738	T22727	conj	other,one
R7019	T22739	T22738	amod	heterozygous,other
R7020	T22740	T22739	prep	for,heterozygous
R7021	T22741	T22740	pobj	QTL,for
R7022	T22742	T22741	prep	on,QTL
R7023	T22743	T22744	nmod	MMU,5
R7024	T22744	T22742	pobj	5,on
R7025	T22745	T22744	punct	", ",5
R7026	T22746	T22744	conj	8,5
R7027	T22747	T22746	punct	", ",8
R7028	T22748	T22746	conj	11,8
R7029	T22749	T22748	cc	and,11
R7030	T22750	T22748	conj	17,11
R7031	T22751	T22752	punct	(,Figure
R7032	T22752	T22719	parataxis	Figure,selected
R7033	T22753	T22752	nummod	1,Figure
R7034	T22754	T22752	punct	),Figure
R7035	T22755	T22719	punct	.,selected
R7036	T22757	T22758	det	Both,males
R7037	T22758	T22759	nsubj	males,were
R7038	T22760	T22759	acomp	homozygous,were
R7039	T22761	T22760	prep	for,homozygous
R7040	T22762	T22763	compound	HG,alleles
R7041	T22763	T22761	pobj	alleles,for
R7042	T22764	T22759	prep	at,were
R7043	T22765	T22766	det	all,QTL
R7044	T22766	T22764	pobj	QTL,at
R7045	T22767	T22766	amod	other,QTL
R7046	T22768	T22766	amod	known,QTL
R7047	T22769	T22759	punct	.,were
R7048	T22771	T22772	det	These,males
R7049	T22772	T22773	nsubjpass	males,backcrossed
R7050	T22774	T22773	auxpass	were,backcrossed
R7051	T22775	T22773	prep	to,backcrossed
R7052	T22776	T22777	compound	HG,females
R7053	T22777	T22775	pobj	females,to
R7054	T22778	T22773	cc	and,backcrossed
R7055	T22779	T22780	nsubjpass	two,selected
R7056	T22780	T22773	conj	selected,backcrossed
R7057	T22781	T22779	prep	of,two
R7058	T22782	T22783	det	the,males
R7059	T22783	T22781	pobj	males,of
R7060	T22784	T22783	amod	resulting,males
R7061	T22785	T22783	compound	N3,males
R7062	T22786	T22783	acl	inheriting,males
R7063	T22787	T22788	det	the,sets
R7064	T22788	T22786	dobj	sets,inheriting
R7065	T22789	T22788	amod	same,sets
R7066	T22790	T22788	prep	of,sets
R7067	T22791	T22790	pobj	QTL,of
R7068	T22792	T22788	prep	as,sets
R7069	T22793	T22794	poss	their,sire
R7070	T22794	T22792	pobj	sire,as
R7071	T22795	T22780	auxpass	were,selected
R7072	T22796	T22780	prep	for,selected
R7073	T22797	T22796	pobj	breeding,for
R7074	T22798	T22780	punct	.,selected
R7075	T22800	T22801	det	These,males
R7076	T22801	T22802	nsubjpass	males,backcrossed
R7077	T22803	T22802	auxpass	were,backcrossed
R7078	T22804	T22802	advmod	subsequently,backcrossed
R7079	T22805	T22802	prep	to,backcrossed
R7080	T22806	T22807	compound	HG,females
R7081	T22807	T22805	pobj	females,to
R7082	T22808	T22802	cc	and,backcrossed
R7083	T22809	T22810	nummod	three,males
R7084	T22810	T22812	nsubjpass	males,identified
R7085	T22811	T22810	compound	N4,males
R7086	T22812	T22802	conj	identified,backcrossed
R7087	T22813	T22812	auxpass	were,identified
R7088	T22814	T22812	acomp	heterozygous,identified
R7089	T22815	T22814	prep	for,heterozygous
R7090	T22816	T22817	det	the,regions
R7091	T22817	T22815	pobj	regions,for
R7092	T22818	T22817	amod	following,regions
R7093	T22819	T22817	punct	: ,regions
R7094	T22820	T22821	meta	1,1
R7095	T22821	T22817	appos	1,regions
R7096	T22822	T22820	punct	),1
R7097	T22823	T22821	nmod	MMU,1
R7098	T22824	T22821	cc	and,1
R7099	T22825	T22821	conj	9,1
R7100	T22826	T22821	punct	;,1
R7101	T22827	T22828	meta	2,5
R7102	T22828	T22821	appos	5,1
R7103	T22829	T22827	punct	),2
R7104	T22830	T22828	nmod	MMU,5
R7105	T22831	T22828	cc	and,5
R7106	T22832	T22828	conj	11,5
R7107	T22833	T22821	punct	;,1
R7108	T22834	T22835	meta	3,8
R7109	T22835	T22821	appos	8,1
R7110	T22836	T22834	punct	),3
R7111	T22837	T22835	nmod	MMU,8
R7112	T22838	T22835	punct	", ",8
R7113	T22839	T22835	conj	11,8
R7114	T22840	T22839	cc	and,11
R7115	T22841	T22839	conj	17,11
R7116	T22842	T22843	punct	(,Figure
R7117	T22843	T22812	parataxis	Figure,identified
R7118	T22844	T22843	nummod	1,Figure
R7119	T22845	T22843	punct	),Figure
R7120	T22846	T22812	punct	.,identified
R7121	T22848	T22849	advcl	Starting,selected
R7122	T22850	T22848	prep	at,Starting
R7123	T22851	T22850	pobj	N4,at
R7124	T22852	T22848	cc	and,Starting
R7125	T22853	T22848	conj	continuing,Starting
R7126	T22854	T22853	prep	through,continuing
R7127	T22855	T22854	pobj	N6,through
R7128	T22856	T22849	punct	", ",selected
R7129	T22857	T22858	det	the,male
R7130	T22858	T22849	nsubjpass	male,selected
R7131	T22859	T22858	punct	"""",male
R7132	T22860	T22858	amod	best,male
R7133	T22861	T22858	punct	"""",male
R7134	T22862	T22858	prep	with,male
R7135	T22863	T22864	det	the,percent
R7136	T22864	T22862	pobj	percent,with
R7137	T22865	T22864	amod	lowest,percent
R7138	T22866	T22864	prep	of,percent
R7139	T22867	T22868	amod	unwanted,alleles
R7140	T22868	T22866	pobj	alleles,of
R7141	T22869	T22868	compound	donor,alleles
R7142	T22870	T22849	auxpass	was,selected
R7143	T22871	T22849	prep	after,selected
R7144	T22872	T22871	pcomp	performing,after
R7145	T22873	T22874	det	a,scan
R7146	T22874	T22872	dobj	scan,performing
R7147	T22875	T22874	compound	genome,scan
R7148	T22876	T22872	advcl	using,performing
R7149	T22877	T22878	det	the,markers
R7150	T22878	T22876	dobj	markers,using
R7151	T22879	T22878	amod	remaining,markers
R7152	T22880	T22878	nummod	67,markers
R7153	T22881	T22882	npadvmod	genome,wide
R7154	T22882	T22878	amod	wide,markers
R7155	T22883	T22882	punct	-,wide
R7156	T22884	T22885	punct	(,markers
R7157	T22885	T22878	parataxis	markers,markers
R7158	T22886	T22885	nummod	79,markers
R7159	T22887	T22885	amod	total,markers
R7160	T22888	T22885	cc	minus,markers
R7161	T22889	T22890	det	the,markers
R7162	T22890	T22885	conj	markers,markers
R7163	T22891	T22890	nummod	12,markers
R7164	T22892	T22890	acl	genotyped,markers
R7165	T22893	T22892	prep	in,genotyped
R7166	T22894	T22895	det	the,backcrosses
R7167	T22895	T22893	pobj	backcrosses,in
R7168	T22896	T22895	amod	first,backcrosses
R7169	T22897	T22895	nummod	two,backcrosses
R7170	T22898	T22895	acl	spanning,backcrosses
R7171	T22899	T22900	det	the,intervals
R7172	T22900	T22898	dobj	intervals,spanning
R7173	T22901	T22900	amod	know,intervals
R7174	T22902	T22900	compound	QTL,intervals
R7175	T22903	T22885	punct	),markers
R7176	T22904	T22849	punct	.,selected
R7177	T22906	T22907	prep	At,created
R7178	T22908	T22906	pobj	N5,At
R7179	T22909	T22910	det	a,strain
R7180	T22910	T22907	nsubjpass	strain,created
R7181	T22911	T22910	amod	distinct,strain
R7182	T22912	T22907	auxpass	was,created
R7183	T22913	T22907	prep	for,created
R7184	T22914	T22913	pobj	each,for
R7185	T22915	T22914	prep	of,each
R7186	T22916	T22917	det	the,regions
R7187	T22917	T22915	pobj	regions,of
R7188	T22918	T22917	nummod	six,regions
R7189	T22919	T22917	amod	individual,regions
R7190	T22920	T22917	compound	donor,regions
R7191	T22921	T22907	cc	and,created
R7192	T22922	T22923	amod	heterozygous,mice
R7193	T22923	T22924	nsubjpass	mice,intermated
R7194	T22924	T22907	conj	intermated,created
R7195	T22925	T22924	auxpass	were,intermated
R7196	T22926	T22927	punct	(,Figure
R7197	T22927	T22907	parataxis	Figure,created
R7198	T22928	T22927	nummod	1,Figure
R7199	T22929	T22927	punct	),Figure
R7200	T22930	T22907	punct	.,created
R7201	T22932	T22933	amod	Homozygous,strains
R7202	T22933	T22937	nsubjpass	strains,maintained
R7203	T22934	T22933	nmod	HG.CAST,strains
R7204	T22935	T22936	npadvmod	speed,congenic
R7205	T22936	T22933	amod	congenic,strains
R7206	T22938	T22937	auxpass	were,maintained
R7207	T22939	T22937	prep	through,maintained
R7208	T22940	T22941	compound	brother,sister
R7209	T22941	T22943	compound	sister,mating
R7210	T22942	T22941	punct	-,sister
R7211	T22943	T22939	pobj	mating,through
R7212	T22944	T22937	punct	.,maintained
R7213	T22946	T22947	mark	Once,stabilized
R7214	T22947	T22951	advcl	stabilized,used
R7215	T22948	T22949	det	each,congenic
R7216	T22949	T22947	nsubjpass	congenic,stabilized
R7217	T22950	T22947	auxpass	was,stabilized
R7218	T22952	T22951	punct	", ",used
R7219	T22953	T22954	nummod	19,markers
R7220	T22954	T22951	nsubjpass	markers,used
R7221	T22955	T22954	amod	additional,markers
R7222	T22956	T22954	compound	microsatellite,markers
R7223	T22957	T22951	auxpass	were,used
R7224	T22958	T22959	aux	to,refine
R7225	T22959	T22951	advcl	refine,used
R7226	T22960	T22961	det	the,position
R7227	T22961	T22959	dobj	position,refine
R7228	T22962	T22961	prep	of,position
R7229	T22963	T22964	det	each,point
R7230	T22964	T22962	pobj	point,of
R7231	T22965	T22964	amod	congenic,point
R7232	T22966	T22964	amod	recombinant,point
R7233	T22967	T22964	compound	end,point
R7234	T22968	T22969	punct	(,File
R7235	T22969	T22951	parataxis	File,used
R7236	T22970	T22969	amod	Additional,File
R7237	T22971	T22969	nummod	2,File
R7238	T22972	T22969	punct	),File
R7239	T22973	T22951	punct	.,used
R7240	T23421	T23420	prep	of,Development
R7241	T23422	T23423	nmod	B6.CASTC,strains
R7242	T23423	T23421	pobj	strains,of
R7243	T23424	T23422	cc	and,B6.CASTC
R7244	T23425	T23422	conj	HG.CASTC,B6.CASTC
R7245	T23426	T23423	compound	control,strains
R7246	T23428	T23429	nsubj	HG,is
R7247	T23429	T23430	ccomp	is,be
R7248	T23431	T23432	det	a,strain
R7249	T23432	T23429	attr	strain,is
R7250	T23433	T23434	prep	in,introgressed
R7251	T23434	T23432	relcl	introgressed,strain
R7252	T23435	T23433	pobj	which,in
R7253	T23436	T23437	det	the,deletion
R7254	T23437	T23434	nsubjpass	deletion,introgressed
R7255	T23438	T23437	compound	hg,deletion
R7256	T23439	T23434	aux	has,introgressed
R7257	T23440	T23434	auxpass	been,introgressed
R7258	T23441	T23434	prep	onto,introgressed
R7259	T23442	T23443	det	a,background
R7260	T23443	T23441	pobj	background,onto
R7261	T23444	T23443	compound	B6,background
R7262	T23445	T23430	punct	", ",be
R7263	T23446	T23430	advmod	therefore,be
R7264	T23447	T23448	det	the,differences
R7265	T23448	T23430	nsubj	differences,be
R7266	T23449	T23448	amod	only,differences
R7267	T23450	T23448	amod	genetic,differences
R7268	T23451	T23448	prep	between,differences
R7269	T23452	T23453	det	the,strains
R7270	T23453	T23451	pobj	strains,between
R7271	T23454	T23430	aux	would,be
R7272	T23455	T23456	det	the,locus
R7273	T23456	T23430	attr	locus,be
R7274	T23457	T23456	compound	hg,locus
R7275	T23458	T23456	punct	", ",locus
R7276	T23459	T23460	advmod	tightly,linked
R7277	T23460	T23461	amod	linked,alleles
R7278	T23461	T23456	conj	alleles,locus
R7279	T23462	T23461	prep	from,alleles
R7280	T23463	T23464	det	the,strain
R7281	T23464	T23462	pobj	strain,from
R7282	T23465	T23464	amod	outbred,strain
R7283	T23466	T23467	prep	on,arose
R7284	T23467	T23464	relcl	arose,strain
R7285	T23468	T23466	pobj	which,on
R7286	T23469	T23467	nsubj	hg,arose
R7287	T23470	T23461	cc	and,alleles
R7288	T23471	T23472	amod	contaminating,alleles
R7289	T23472	T23461	conj	alleles,alleles
R7290	T23473	T23472	acl	remaining,alleles
R7291	T23474	T23473	prep	after,remaining
R7292	T23475	T23476	det	the,backcrosses
R7293	T23476	T23474	pobj	backcrosses,after
R7294	T23477	T23476	nummod	nine,backcrosses
R7295	T23478	T23473	cc	and,remaining
R7296	T23479	T23473	conj	fixed,remaining
R7297	T23480	T23479	prep	during,fixed
R7298	T23481	T23480	pobj	inbreeding,during
R7299	T23482	T23430	punct	.,be
R7300	T23484	T23485	advmod	Instead,of
R7301	T23485	T23486	prep	of,choose
R7302	T23487	T23485	pcomp	using,of
R7303	T23488	T23489	amod	parental,strains
R7304	T23489	T23487	dobj	strains,using
R7305	T23490	T23489	nmod	B6,strains
R7306	T23491	T23490	cc	and,B6
R7307	T23492	T23490	conj	HG,B6
R7308	T23493	T23487	prep	as,using
R7309	T23494	T23493	pobj	controls,as
R7310	T23495	T23494	prep	for,controls
R7311	T23496	T23497	amod	phenotypic,comparisons
R7312	T23497	T23495	pobj	comparisons,for
R7313	T23498	T23497	prep	with,comparisons
R7314	T23499	T23500	det	each,speed
R7315	T23500	T23498	pobj	speed,with
R7316	T23501	T23500	amod	congenic,speed
R7317	T23502	T23486	punct	", ",choose
R7318	T23503	T23486	nsubj	we,choose
R7319	T23504	T23505	aux	to,develop
R7320	T23505	T23486	xcomp	develop,choose
R7321	T23506	T23507	amod	independent,strains
R7322	T23507	T23505	dobj	strains,develop
R7323	T23508	T23507	compound	control,strains
R7324	T23509	T23507	acl	originating,strains
R7325	T23510	T23509	prep	from,originating
R7326	T23511	T23512	det	the,cross
R7327	T23512	T23510	pobj	cross,from
R7328	T23513	T23512	amod	same,cross
R7329	T23514	T23512	prep	as,cross
R7330	T23515	T23516	det	the,panels
R7331	T23516	T23514	pobj	panels,as
R7332	T23517	T23516	amod	congenic,panels
R7333	T23518	T23486	punct	.,choose
R7334	T23520	T23521	amod	Separate,strains
R7335	T23521	T23533	nsubjpass	strains,developed
R7336	T23522	T23523	nmod	B6.CAST,control
R7337	T23523	T23521	nmod	control,strains
R7338	T23524	T23523	punct	(,control
R7339	T23525	T23523	appos	B6C,control
R7340	T23526	T23523	punct	),control
R7341	T23527	T23523	cc	and,control
R7342	T23528	T23529	compound	HG.CAST,control
R7343	T23529	T23523	conj	control,control
R7344	T23530	T23529	punct	(,control
R7345	T23531	T23529	appos	HGC,control
R7346	T23532	T23521	punct	),strains
R7347	T23534	T23533	auxpass	were,developed
R7348	T23535	T23533	advcl	using,developed
R7349	T23536	T23535	dobj	mice,using
R7350	T23537	T23536	prep	from,mice
R7351	T23538	T23539	det	the,experiment
R7352	T23539	T23537	pobj	experiment,from
R7353	T23540	T23539	compound	MMU2,experiment
R7354	T23541	T23533	punct	.,developed
R7355	T23543	T23544	nsubjpass	Mice,intermated
R7356	T23545	T23543	prep	from,Mice
R7357	T23546	T23547	det	the,backcross
R7358	T23547	T23545	pobj	backcross,from
R7359	T23548	T23547	amod	last,backcross
R7360	T23549	T23543	acl	inheriting,Mice
R7361	T23550	T23551	advmod	only,alleles
R7362	T23551	T23549	dobj	alleles,inheriting
R7363	T23552	T23551	nmod	B6,alleles
R7364	T23553	T23552	cc	or,B6
R7365	T23554	T23552	conj	HG,B6
R7366	T23555	T23551	compound	MMU2,alleles
R7367	T23556	T23549	prep	at,inheriting
R7368	T23557	T23556	pobj	markers,at
R7369	T23558	T23557	acl	spanning,markers
R7370	T23559	T23558	dobj	MMU2,spanning
R7371	T23560	T23544	auxpass	were,intermated
R7372	T23561	T23562	aux	to,serve
R7373	T23562	T23544	advcl	serve,intermated
R7374	T23563	T23562	prep	as,serve
R7375	T23564	T23565	det	the,basis
R7376	T23565	T23563	pobj	basis,as
R7377	T23566	T23565	prep	for,basis
R7378	T23567	T23568	det	each,control
R7379	T23568	T23566	pobj	control,for
R7380	T23569	T23544	punct	.,intermated
R7381	T23571	T23572	det	Both,strains
R7382	T23572	T23574	nsubjpass	strains,maintained
R7383	T23573	T23572	compound	control,strains
R7384	T23575	T23574	auxpass	were,maintained
R7385	T23576	T23574	advmod	subsequently,maintained
R7386	T23577	T23574	prep	through,maintained
R7387	T23578	T23579	compound	brother,sister
R7388	T23579	T23581	compound	sister,mating
R7389	T23580	T23579	punct	-,sister
R7390	T23581	T23577	pobj	mating,through
R7391	T23582	T23574	punct	.,maintained
R7392	T23584	T23585	det	The,strains
R7393	T23585	T23587	nsubj	strains,were
R7394	T23586	T23585	compound	control,strains
R7395	T23588	T23587	acomp	coisogenic,were
R7396	T23589	T23588	prep	with,coisogenic
R7397	T23590	T23591	det	the,strain
R7398	T23591	T23589	pobj	strain,with
R7399	T23592	T23591	amod	parental,strain
R7400	T23593	T23591	nmod	B6,strain
R7401	T23594	T23593	cc	or,B6
R7402	T23595	T23593	conj	HG,B6
R7403	T23596	T23587	prep	with,were
R7404	T23597	T23598	det	the,exception
R7405	T23598	T23596	pobj	exception,with
R7406	T23599	T23598	prep	of,exception
R7407	T23600	T23599	pobj	mutations,of
R7408	T23601	T23602	dep	that,arose
R7409	T23602	T23600	relcl	arose,mutations
R7410	T23603	T23602	prep	during,arose
R7411	T23604	T23605	amod	congenic,construction
R7412	T23605	T23603	pobj	construction,during
R7413	T23606	T23600	cc	and,mutations
R7414	T23607	T23608	det	a,percentage
R7415	T23608	T23600	conj	percentage,mutations
R7416	T23609	T23608	amod	small,percentage
R7417	T23610	T23608	prep	of,percentage
R7418	T23611	T23612	amod	contaminating,alleles
R7419	T23612	T23610	pobj	alleles,of
R7420	T23613	T23612	compound	donor,alleles
R7421	T23614	T23612	acl	missed,alleles
R7422	T23615	T23614	prep	after,missed
R7423	T23616	T23617	nummod	6,backcrosses
R7424	T23617	T23615	pobj	backcrosses,after
R7425	T23618	T23587	punct	.,were
R7426	T23620	T23621	advmod	Therefore,are
R7427	T23622	T23621	punct	", ",are
R7428	T23623	T23624	mark	since,developed
R7429	T23624	T23621	advcl	developed,are
R7430	T23625	T23626	det	the,congenics
R7431	T23626	T23624	nsubjpass	congenics,developed
R7432	T23627	T23626	cc	and,congenics
R7433	T23628	T23626	conj	controls,congenics
R7434	T23629	T23624	auxpass	were,developed
R7435	T23630	T23624	prep	through,developed
R7436	T23631	T23632	det	the,scheme
R7437	T23632	T23630	pobj	scheme,through
R7438	T23633	T23632	amod	same,scheme
R7439	T23634	T23632	compound	selection,scheme
R7440	T23635	T23624	cc	and,developed
R7441	T23636	T23637	advmod	possibly,share
R7442	T23637	T23624	conj	share,developed
R7443	T23638	T23639	amod	common,regions
R7444	T23639	T23637	dobj	regions,share
R7445	T23640	T23639	amod	contaminating,regions
R7446	T23641	T23621	punct	", ",are
R7447	T23642	T23643	det	the,strains
R7448	T23643	T23621	nsubj	strains,are
R7449	T23644	T23643	nmod	B6C,strains
R7450	T23645	T23644	cc	and,B6C
R7451	T23646	T23644	conj	HGC,B6C
R7452	T23647	T23648	det	the,control
R7453	T23648	T23621	attr	control,are
R7454	T23649	T23648	advmod	most,control
R7455	T23650	T23648	amod	ideal,control
R7456	T23651	T23652	aux	to,compare
R7457	T23652	T23648	advcl	compare,control
R7458	T23653	T23654	det	each,congenic
R7459	T23654	T23652	dobj	congenic,compare
R7460	T23655	T23621	punct	.,are
R7463	T24427	T24428	amod	Phenotypic,characterization
R7464	T24430	T24431	compound	Trait,data
R7465	T24431	T24432	nsubjpass	data,collected
R7466	T24433	T24432	auxpass	were,collected
R7467	T24434	T24432	prep	on,collected
R7468	T24435	T24436	advmod	approximately,40
R7469	T24436	T24437	nummod	40,mice
R7470	T24437	T24434	pobj	mice,on
R7471	T24438	T24439	punct	(,20
R7472	T24439	T24437	parataxis	20,mice
R7473	T24440	T24439	prep	of,20
R7474	T24441	T24442	det	each,sex
R7475	T24442	T24440	pobj	sex,of
R7476	T24443	T24439	punct	),20
R7477	T24444	T24437	prep	from,mice
R7478	T24445	T24446	det	each,strain
R7479	T24446	T24444	pobj	strain,from
R7480	T24447	T24446	amod	congenic,strain
R7481	T24448	T24447	cc	and,congenic
R7482	T24449	T24447	conj	control,congenic
R7483	T24450	T24432	punct	.,collected
R7484	T24452	T24453	aux	To,eliminate
R7485	T24453	T24454	advcl	eliminate,characterized
R7486	T24455	T24453	dobj	parity,eliminate
R7487	T24456	T24453	cc	and,eliminate
R7488	T24457	T24453	conj	reduce,eliminate
R7489	T24458	T24459	compound	litter,size
R7490	T24459	T24460	compound	size,effects
R7491	T24460	T24457	dobj	effects,reduce
R7492	T24461	T24462	advmod	only,progeny
R7493	T24462	T24454	nsubjpass	progeny,characterized
R7494	T24463	T24462	prep	from,progeny
R7495	T24464	T24465	amod	uniparous,dams
R7496	T24465	T24463	pobj	dams,from
R7497	T24466	T24454	auxpass	were,characterized
R7498	T24467	T24454	cc	and,characterized
R7499	T24468	T24469	det	all,litters
R7500	T24469	T24470	nsubjpass	litters,standardized
R7501	T24470	T24454	conj	standardized,characterized
R7502	T24471	T24470	auxpass	were,standardized
R7503	T24472	T24470	prep	to,standardized
R7504	T24473	T24474	quantmod	5,7
R7505	T24474	T24476	nummod	7,pups
R7506	T24475	T24474	punct	–,7
R7507	T24476	T24472	pobj	pups,to
R7508	T24477	T24478	punct	/,litter
R7509	T24478	T24476	prep	litter,pups
R7510	T24479	T24470	punct	.,standardized
R7511	T24481	T24482	nsubjpass	Mice,weaned
R7512	T24483	T24482	auxpass	were,weaned
R7513	T24484	T24482	prep	at,weaned
R7514	T24485	T24486	nummod	3,weeks
R7515	T24486	T24484	pobj	weeks,at
R7516	T24487	T24486	prep	of,weeks
R7517	T24488	T24487	pobj	age,of
R7518	T24489	T24482	punct	.,weaned
R7519	T24491	T24492	nsubjpass	Feed,offered
R7520	T24493	T24494	punct	(,protein
R7521	T24494	T24491	parataxis	protein,Feed
R7522	T24495	T24494	dep	Purina,protein
R7523	T24496	T24495	nummod	5008,Purina
R7524	T24497	T24494	punct	;,protein
R7525	T24498	T24499	nummod	23.5,%
R7526	T24499	T24494	compound	%,protein
R7527	T24500	T24494	punct	", ",protein
R7528	T24501	T24502	nummod	6.5,%
R7529	T24502	T24503	compound	%,fat
R7530	T24503	T24494	appos	fat,protein
R7531	T24504	T24494	punct	", ",protein
R7532	T24505	T24506	nummod	3.3,Kcal
R7533	T24506	T24494	appos	Kcal,protein
R7534	T24507	T24508	punct	/,g
R7535	T24508	T24506	prep	g,Kcal
R7536	T24509	T24494	punct	),protein
R7537	T24510	T24491	cc	and,Feed
R7538	T24511	T24491	conj	water,Feed
R7539	T24512	T24492	auxpass	were,offered
R7540	T24513	T24514	advmod	ad,libitum
R7541	T24514	T24492	advmod	libitum,offered
R7542	T24515	T24492	punct	.,offered
R7543	T24517	T24518	nsubjpass	Mice,weighed
R7544	T24519	T24518	auxpass	were,weighed
R7545	T24520	T24518	prep	to,weighed
R7546	T24521	T24522	det	the,g
R7547	T24522	T24520	pobj	g,to
R7548	T24523	T24522	amod	nearest,g
R7549	T24524	T24522	nummod	0.1,g
R7550	T24525	T24518	prep	at,weighed
R7551	T24526	T24525	pobj	2WK,at
R7552	T24527	T24526	punct	", ",2WK
R7553	T24528	T24526	conj	3WK,2WK
R7554	T24529	T24528	punct	", ",3WK
R7555	T24530	T24528	conj	6WK,3WK
R7556	T24531	T24530	punct	", ",6WK
R7557	T24532	T24530	cc	and,6WK
R7558	T24533	T24530	conj	9WK,6WK
R7559	T24534	T24526	prep	of,2WK
R7560	T24535	T24534	pobj	age,of
R7561	T24536	T24518	punct	.,weighed
R7562	T24538	T24539	prep	At,anesthetized
R7563	T24540	T24538	pobj	9WK,At
R7564	T24541	T24540	punct	(,9WK
R7565	T24542	T24540	punct	±,9WK
R7566	T24543	T24544	nummod	5,days
R7567	T24544	T24540	appos	days,9WK
R7568	T24545	T24540	punct	),9WK
R7569	T24546	T24539	nsubjpass	mice,anesthetized
R7570	T24547	T24539	auxpass	were,anesthetized
R7571	T24548	T24539	prep	under,anesthetized
R7572	T24549	T24548	pobj	isoflurane,under
R7573	T24550	T24539	cc	and,anesthetized
R7574	T24551	T24552	amod	nasal,anal
R7575	T24552	T24554	amod	anal,length
R7576	T24553	T24552	punct	-,anal
R7577	T24554	T24555	nsubjpass	length,measured
R7578	T24555	T24539	conj	measured,anesthetized
R7579	T24556	T24554	punct	(,length
R7580	T24557	T24554	appos	NA,length
R7581	T24558	T24554	punct	),length
R7582	T24559	T24554	cc	and,length
R7583	T24560	T24561	amod	nasal,tail
R7584	T24561	T24554	conj	tail,length
R7585	T24562	T24561	punct	-,tail
R7586	T24563	T24561	punct	(,tail
R7587	T24564	T24561	appos	NT,tail
R7588	T24565	T24555	punct	),measured
R7589	T24566	T24555	auxpass	were,measured
R7590	T24567	T24555	prep	to,measured
R7591	T24568	T24569	det	the,mm
R7592	T24569	T24567	pobj	mm,to
R7593	T24570	T24569	amod	nearest,mm
R7594	T24571	T24539	punct	.,anesthetized
R7595	T24573	T24574	compound	Tail,length
R7596	T24574	T24575	nsubjpass	length,calculated
R7597	T24576	T24575	auxpass	was,calculated
R7598	T24577	T24575	prep	as,calculated
R7599	T24578	T24577	pobj	NA,as
R7600	T24579	T24578	cc	minus,NA
R7601	T24580	T24578	conj	NT,NA
R7602	T24581	T24575	punct	.,calculated
R7603	T24583	T24584	amod	Anesthetized,mice
R7604	T24584	T24585	nsubjpass	mice,sacrificed
R7605	T24586	T24585	auxpass	were,sacrificed
R7606	T24587	T24585	advmod	then,sacrificed
R7607	T24588	T24585	prep	by,sacrificed
R7608	T24589	T24588	pobj	decapitation,by
R7609	T24590	T24585	cc	and,sacrificed
R7610	T24591	T24585	conj	exsanguinated,sacrificed
R7611	T24592	T24585	punct	.,sacrificed
R7612	T24594	T24595	amod	Femoral,pad
R7613	T24595	T24597	nsubjpass	pad,removed
R7614	T24596	T24595	compound	fat,pad
R7615	T24598	T24595	punct	(,pad
R7616	T24599	T24595	appos	FFP,pad
R7617	T24600	T24595	punct	),pad
R7618	T24601	T24595	punct	", ",pad
R7619	T24602	T24603	amod	gonadal,pad
R7620	T24603	T24595	conj	pad,pad
R7621	T24604	T24603	compound	fat,pad
R7622	T24605	T24603	punct	(,pad
R7623	T24606	T24603	appos	GFP,pad
R7624	T24607	T24603	punct	),pad
R7625	T24608	T24603	punct	", ",pad
R7626	T24609	T24610	amod	mesenteric,pad
R7627	T24610	T24603	conj	pad,pad
R7628	T24611	T24610	compound	fat,pad
R7629	T24612	T24610	punct	(,pad
R7630	T24613	T24610	appos	MFP,pad
R7631	T24614	T24610	punct	),pad
R7632	T24615	T24610	cc	and,pad
R7633	T24616	T24617	amod	retroperitoneal,pad
R7634	T24617	T24610	conj	pad,pad
R7635	T24618	T24617	compound	fat,pad
R7636	T24619	T24617	punct	(,pad
R7637	T24620	T24617	appos	RFP,pad
R7638	T24621	T24597	punct	),removed
R7639	T24622	T24597	auxpass	were,removed
R7640	T24623	T24597	cc	and,removed
R7641	T24624	T24597	conj	weighed,removed
R7642	T24625	T24624	prep	to,weighed
R7643	T24626	T24627	det	the,mg
R7644	T24627	T24625	pobj	mg,to
R7645	T24628	T24627	amod	nearest,mg
R7646	T24629	T24597	punct	.,removed
R7647	T24631	T24632	amod	Chemical,analysis
R7648	T24632	T24634	nsubjpass	analysis,performed
R7649	T24633	T24632	amod	compositional,analysis
R7650	T24635	T24634	auxpass	was,performed
R7651	T24636	T24634	prep	for,performed
R7652	T24637	T24638	nmod	HGC,carcasses
R7653	T24638	T24636	pobj	carcasses,for
R7654	T24639	T24637	punct	", ",HGC
R7655	T24640	T24637	conj	HG11,HGC
R7656	T24641	T24640	cc	and,HG11
R7657	T24642	T24640	conj	HG17,HG11
R7658	T24643	T24644	mark	as,described
R7659	T24644	T24634	advcl	described,performed
R7660	T24645	T24644	advmod	previously,described
R7661	T24646	T24634	prep	with,performed
R7662	T24647	T24648	amod	slight,modifications
R7663	T24648	T24646	pobj	modifications,with
R7664	T24649	T24650	punct	[,24
R7665	T24650	T24634	parataxis	24,performed
R7666	T24651	T24650	punct	],24
R7667	T24652	T24634	punct	.,performed
R7668	T24654	T24655	advmod	Briefly,returned
R7669	T24656	T24655	punct	", ",returned
R7670	T24657	T24655	prep	after,returned
R7671	T24658	T24657	pobj	weighing,after
R7672	T24659	T24660	det	each,pad
R7673	T24660	T24655	nsubjpass	pad,returned
R7674	T24661	T24660	compound	fat,pad
R7675	T24662	T24655	auxpass	was,returned
R7676	T24663	T24655	prep	to,returned
R7677	T24664	T24665	det	the,carcass
R7678	T24665	T24663	pobj	carcass,to
R7679	T24666	T24655	punct	.,returned
R7680	T24668	T24669	det	The,tract
R7681	T24669	T24675	nsubjpass	tract,removed
R7682	T24670	T24669	amod	entire,tract
R7683	T24671	T24669	amod	gastrointestinal,tract
R7684	T24672	T24673	punct	(,GI
R7685	T24673	T24669	parataxis	GI,tract
R7686	T24674	T24673	punct	),GI
R7687	T24676	T24675	auxpass	was,removed
R7688	T24677	T24675	advmod	subsequently,removed
R7689	T24678	T24675	cc	and,removed
R7690	T24679	T24680	nsubjpass	carcasses,weighed
R7691	T24680	T24675	conj	weighed,removed
R7692	T24681	T24680	auxpass	were,weighed
R7693	T24682	T24680	advmod	again,weighed
R7694	T24683	T24680	punct	.,weighed
R7695	T24685	T24686	nsubj	This,represented
R7696	T24687	T24688	det	the,weight
R7697	T24688	T24686	dobj	weight,represented
R7698	T24689	T24690	amod	empty,carcass
R7699	T24690	T24688	compound	carcass,weight
R7700	T24691	T24688	punct	(,weight
R7701	T24692	T24688	appos	ECW,weight
R7702	T24693	T24686	punct	),represented
R7703	T24694	T24686	punct	.,represented
R7704	T24696	T24697	nsubjpass	Carcasses,labeled
R7705	T24698	T24697	auxpass	were,labeled
R7706	T24699	T24697	cc	and,labeled
R7707	T24700	T24697	conj	secured,labeled
R7708	T24701	T24700	prep	in,secured
R7709	T24702	T24703	nummod	two,layers
R7710	T24703	T24701	pobj	layers,in
R7711	T24704	T24703	prep	of,layers
R7712	T24705	T24704	pobj	cheesecloth,of
R7713	T24706	T24707	punct	(,Fisher
R7714	T24707	T24705	parataxis	Fisher,cheesecloth
R7715	T24708	T24707	punct	),Fisher
R7716	T24709	T24700	cc	and,secured
R7717	T24710	T24700	conj	frozen,secured
R7718	T24711	T24710	prep	at,frozen
R7719	T24712	T24713	punct	-,20
R7720	T24713	T24714	nummod	20,°C
R7721	T24714	T24711	pobj	°C,at
R7722	T24715	T24710	prep	until,frozen
R7723	T24716	T24715	pobj	analysis,until
R7724	T24717	T24697	punct	.,labeled
R7725	T24719	T24720	prep	At,dried
R7726	T24721	T24722	det	this,time
R7727	T24722	T24719	pobj	time,At
R7728	T24723	T24720	punct	", ",dried
R7729	T24724	T24720	nsubjpass	carcasses,dried
R7730	T24725	T24720	auxpass	were,dried
R7731	T24726	T24720	dep	freeze,dried
R7732	T24727	T24720	punct	-,dried
R7733	T24728	T24720	prep	for,dried
R7734	T24729	T24730	nummod	seven,days
R7735	T24730	T24728	pobj	days,for
R7736	T24731	T24720	cc	and,dried
R7737	T24732	T24733	compound	water,content
R7738	T24733	T24734	nsubjpass	content,determined
R7739	T24734	T24720	conj	determined,dried
R7740	T24735	T24734	auxpass	was,determined
R7741	T24736	T24734	prep	by,determined
R7742	T24737	T24736	pcomp	subtracting,by
R7743	T24738	T24739	det	the,weight
R7744	T24739	T24737	dobj	weight,subtracting
R7745	T24740	T24741	npadvmod	freeze,dried
R7746	T24741	T24739	amod	dried,weight
R7747	T24742	T24741	punct	-,dried
R7748	T24743	T24737	prep	from,subtracting
R7749	T24744	T24743	pobj	ECW,from
R7750	T24745	T24720	punct	.,dried
R7751	T24747	T24748	nsubjpass	FAT,followed
R7752	T24749	T24748	auxpass	was,followed
R7753	T24750	T24748	advmod	then,followed
R7754	T24751	T24748	aux	extracted,followed
R7755	T24752	T24748	prep	with,followed
R7756	T24753	T24752	pobj	ether,with
R7757	T24754	T24748	prep	for,followed
R7758	T24755	T24756	nummod	7,days
R7759	T24756	T24754	pobj	days,for
R7760	T24757	T24748	punct	", ",followed
R7761	T24758	T24748	agent	by,followed
R7762	T24759	T24758	pobj	acetone,by
R7763	T24760	T24748	prep	for,followed
R7764	T24761	T24762	det	an,days
R7765	T24762	T24760	pobj	days,for
R7766	T24763	T24762	amod	additional,days
R7767	T24764	T24762	nummod	7,days
R7768	T24765	T24748	prep	in,followed
R7769	T24766	T24767	det	a,apparatus
R7770	T24767	T24765	pobj	apparatus,in
R7771	T24768	T24767	compound	Soxhlet,apparatus
R7772	T24769	T24748	punct	.,followed
R7773	T24771	T24772	compound	Carcass,ash
R7774	T24772	T24773	nsubjpass	ash,determined
R7775	T24774	T24772	punct	(,ash
R7776	T24775	T24772	appos	ASH,ash
R7777	T24776	T24773	punct	),determined
R7778	T24777	T24773	auxpass	was,determined
R7779	T24778	T24773	advcl	measuring,determined
R7780	T24779	T24780	det	the,remains
R7781	T24780	T24778	dobj	remains,measuring
R7782	T24781	T24778	prep	after,measuring
R7783	T24782	T24783	det	a,incineration
R7784	T24783	T24781	pobj	incineration,after
R7785	T24784	T24785	nummod	16,hour
R7786	T24785	T24783	compound	hour,incineration
R7787	T24786	T24783	prep	at,incineration
R7788	T24787	T24788	nummod	575,°C
R7789	T24788	T24786	pobj	°C,at
R7790	T24789	T24773	punct	.,determined
R7791	T24791	T24792	compound	Carcass,protein
R7792	T24792	T24793	nsubjpass	protein,calculated
R7793	T24794	T24792	punct	(,protein
R7794	T24795	T24792	appos	PROT,protein
R7795	T24796	T24793	punct	),calculated
R7796	T24797	T24793	auxpass	was,calculated
R7797	T24798	T24793	prep	as,calculated
R7798	T24799	T24800	det	the,portion
R7799	T24800	T24798	pobj	portion,as
R7800	T24801	T24800	amod	remaining,portion
R7801	T24802	T24803	mark	after,subtracted
R7802	T24803	T24800	advcl	subtracted,portion
R7803	T24804	T24805	compound	carcass,fat
R7804	T24805	T24803	nsubjpass	fat,subtracted
R7805	T24806	T24805	punct	(,fat
R7806	T24807	T24805	appos	FAT,fat
R7807	T24808	T24805	punct	),fat
R7808	T24809	T24805	cc	and,fat
R7809	T24810	T24805	conj	ASH,fat
R7810	T24811	T24803	auxpass	were,subtracted
R7811	T24812	T24803	prep	from,subtracted
R7812	T24813	T24812	pobj	ECW,from
R7813	T24814	T24793	punct	.,calculated
R7814	T25106	T25107	amod	Statistical,analysis
R7815	T25109	T25110	det	The,procedures
R7816	T25110	T25114	nsubjpass	procedures,used
R7817	T25111	T25110	nmod	MEANS,procedures
R7818	T25112	T25111	cc	and,MEANS
R7819	T25113	T25111	conj	UNIVARIATE,MEANS
R7820	T25115	T25110	prep	of,procedures
R7821	T25116	T25115	pobj	SAS,of
R7822	T25117	T25114	auxpass	were,used
R7823	T25118	T25119	aux	to,generate
R7824	T25119	T25114	advcl	generate,used
R7825	T25120	T25121	amod	descriptive,statistics
R7826	T25121	T25119	dobj	statistics,generate
R7827	T25122	T25119	cc	and,generate
R7828	T25123	T25119	conj	test,generate
R7829	T25124	T25125	compound	normality,assumptions
R7830	T25125	T25123	dobj	assumptions,test
R7831	T25126	T25125	prep	for,assumptions
R7832	T25127	T25128	det	each,trait
R7833	T25128	T25126	pobj	trait,for
R7834	T25129	T25130	punct	[,55
R7835	T25130	T25114	parataxis	55,used
R7836	T25131	T25130	punct	],55
R7837	T25132	T25114	punct	.,used
R7838	T25134	T25135	det	All,data
R7839	T25135	T25136	nsubjpass	data,analyzed
R7840	T25136	T25139	ccomp	analyzed,used
R7841	T25137	T25136	auxpass	were,analyzed
R7842	T25138	T25136	advmod	then,analyzed
R7843	T25140	T25136	advcl	using,analyzed
R7844	T25141	T25142	det	the,procedure
R7845	T25142	T25140	dobj	procedure,using
R7846	T25143	T25142	compound	GLM,procedure
R7847	T25144	T25142	prep	of,procedure
R7848	T25145	T25144	pobj	SAS,of
R7849	T25146	T25147	punct	[,55
R7850	T25147	T25140	parataxis	55,using
R7851	T25148	T25147	punct	],55
R7852	T25149	T25140	prep	with,using
R7853	T25150	T25151	det	a,model
R7854	T25151	T25149	pobj	model,with
R7855	T25152	T25151	amod	linear,model
R7856	T25153	T25154	dep	that,included
R7857	T25154	T25151	relcl	included,model
R7858	T25155	T25156	det	the,effects
R7859	T25156	T25154	dobj	effects,included
R7860	T25157	T25156	amod	fixed,effects
R7861	T25158	T25156	prep	of,effects
R7862	T25159	T25158	pobj	strain,of
R7863	T25160	T25159	punct	", ",strain
R7864	T25161	T25159	conj	sex,strain
R7865	T25162	T25161	cc	and,sex
R7866	T25163	T25164	nmod	strain,interaction
R7867	T25164	T25161	conj	interaction,sex
R7868	T25165	T25163	prep	by,strain
R7869	T25166	T25165	pobj	sex,by
R7870	T25167	T25139	punct	;,used
R7871	T25168	T25169	poss	dam,weight
R7872	T25169	T25139	nsubjpass	weight,used
R7873	T25170	T25168	case	's,dam
R7874	T25171	T25169	prep	at,weight
R7875	T25172	T25171	pobj	breeding,at
R7876	T25173	T25172	prep	by,breeding
R7877	T25174	T25173	pobj	strain,by
R7878	T25175	T25139	auxpass	was,used
R7879	T25176	T25139	prep	as,used
R7880	T25177	T25178	det	a,covariate
R7881	T25178	T25176	pobj	covariate,as
R7882	T25179	T25139	punct	.,used
R7883	T25181	T25182	det	A,model
R7884	T25182	T25185	nsubjpass	model,used
R7885	T25183	T25182	amod	second,model
R7886	T25184	T25182	amod	linear,model
R7887	T25186	T25185	auxpass	was,used
R7888	T25187	T25188	aux	to,test
R7889	T25188	T25185	advcl	test,used
R7890	T25189	T25188	prep	for,test
R7891	T25190	T25191	nmod	strain,interactions
R7892	T25191	T25189	pobj	interactions,for
R7893	T25192	T25190	prep	by,strain
R7894	T25193	T25194	compound	hg,genotype
R7895	T25194	T25192	pobj	genotype,by
R7896	T25195	T25196	punct	(,+
R7897	T25196	T25191	punct	+,interactions
R7898	T25197	T25196	punct	+,+
R7899	T25198	T25196	punct	/,+
R7900	T25199	T25196	cc	or,+
R7901	T25200	T25201	compound	hg,hg
R7902	T25201	T25196	conj	hg,+
R7903	T25202	T25201	punct	/,hg
R7904	T25203	T25196	punct	),+
R7905	T25204	T25185	punct	.,used
R7906	T25206	T25207	det	This,model
R7907	T25207	T25208	nsubj	model,included
R7908	T25209	T25210	det	the,effects
R7909	T25210	T25208	dobj	effects,included
R7910	T25211	T25210	amod	fixed,effects
R7911	T25212	T25210	prep	of,effects
R7912	T25213	T25214	compound	donor,region
R7913	T25214	T25212	pobj	region,of
R7914	T25215	T25214	punct	", ",region
R7915	T25216	T25214	conj	sex,region
R7916	T25217	T25216	cc	and,sex
R7917	T25218	T25219	compound	HG,genotype
R7918	T25219	T25216	conj	genotype,sex
R7919	T25220	T25210	cc	and,effects
R7920	T25221	T25222	det	all,interactions
R7921	T25222	T25210	conj	interactions,effects
R7922	T25223	T25222	amod	possible,interactions
R7923	T25224	T25225	nummod	two,way
R7924	T25225	T25222	compound	way,interactions
R7925	T25226	T25224	cc	and,two
R7926	T25227	T25224	conj	three,two
R7927	T25228	T25225	punct	-,way
R7928	T25229	T25208	punct	.,included
R7929	T25231	T25232	csubj	Choosing,established
R7930	T25233	T25234	det	a,value
R7931	T25234	T25231	dobj	value,Choosing
R7932	T25235	T25234	amod	nominal,value
R7933	T25236	T25234	compound	P,value
R7934	T25237	T25234	prep	of,value
R7935	T25238	T25237	pobj	0.05,of
R7936	T25239	T25231	cc	and,Choosing
R7937	T25240	T25231	conj	applying,Choosing
R7938	T25241	T25242	det	the,correction
R7939	T25242	T25240	dobj	correction,applying
R7940	T25243	T25242	compound	Bonferroni,correction
R7941	T25244	T25242	prep	for,correction
R7942	T25245	T25246	amod	multiple,comparisons
R7943	T25246	T25244	pobj	comparisons,for
R7944	T25247	T25248	amod	significant,differences
R7945	T25248	T25232	dobj	differences,established
R7946	T25249	T25248	prep	in,differences
R7947	T25250	T25251	det	the,ANOVA
R7948	T25251	T25249	pobj	ANOVA,in
R7949	T25252	T25251	nmod	's,ANOVA
R7950	T25253	T25232	punct	.,established
R7951	T25255	T25256	det	The,values
R7952	T25256	T25259	nsubjpass	values,indicated
R7953	T25257	T25256	amod	critical,values
R7954	T25258	T25256	compound	P,values
R7955	T25260	T25256	acl	used,values
R7956	T25261	T25259	auxpass	are,indicated
R7957	T25262	T25259	prep	in,indicated
R7958	T25263	T25264	det	each,table
R7959	T25264	T25262	pobj	table,in
R7960	T25265	T25259	punct	.,indicated
R7961	T25441	T25440	prep	of,Identification
R7962	T25442	T25443	compound	candidate,genes
R7963	T25443	T25441	pobj	genes,of
R7964	T25445	T25446	nsubjpass	Genes,identified
R7965	T25447	T25446	auxpass	were,identified
R7966	T25448	T25446	agent	by,identified
R7967	T25449	T25450	amod	manual,mining
R7968	T25450	T25448	pobj	mining,by
R7969	T25451	T25450	compound	data,mining
R7970	T25452	T25450	prep	of,mining
R7971	T25453	T25454	amod	primary,literature
R7972	T25454	T25452	pobj	literature,of
R7973	T25455	T25454	punct	", ",literature
R7974	T25456	T25454	conj	reviews,literature
R7975	T25457	T25456	cc	and,reviews
R7976	T25458	T25459	compound	book,chapters
R7977	T25459	T25456	conj	chapters,reviews
R7978	T25460	T25446	punct	.,identified
R7979	T25462	T25463	aux	To,organize
R7980	T25463	T25464	advcl	organize,created
R7981	T25465	T25463	cc	and,organize
R7982	T25466	T25463	conj	collate,organize
R7983	T25467	T25468	amod	genomic,information
R7984	T25468	T25466	dobj	information,collate
R7985	T25469	T25467	cc	and,genomic
R7986	T25470	T25467	conj	functional,genomic
R7987	T25471	T25468	prep	for,information
R7988	T25472	T25473	det	each,gene
R7989	T25473	T25471	pobj	gene,for
R7990	T25474	T25464	nsubj	we,created
R7991	T25475	T25476	det	a,Annotator
R7992	T25476	T25464	dobj	Annotator,created
R7993	T25477	T25478	compound	custom,Gh
R7994	T25478	T25479	compound	Gh,signaling
R7995	T25479	T25476	compound	signaling,Annotator
R7996	T25480	T25481	compound	Gene,Map
R7997	T25481	T25476	compound	Map,Annotator
R7998	T25482	T25476	cc	and,Annotator
R7999	T25483	T25484	nmod	Pathway,Profiler
R8000	T25484	T25485	nmod	Profiler,pathway
R8001	T25485	T25476	conj	pathway,Annotator
R8002	T25486	T25487	punct	(,GenMAPP
R8003	T25487	T25484	parataxis	GenMAPP,Profiler
R8004	T25488	T25487	punct	),GenMAPP
R8005	T25489	T25490	punct	[,56
R8006	T25490	T25464	parataxis	56,created
R8007	T25491	T25490	punct	],56
R8008	T25492	T25493	punct	(,Figure
R8009	T25493	T25464	parataxis	Figure,created
R8010	T25494	T25493	nummod	5,Figure
R8011	T25495	T25493	punct	),Figure
R8012	T25496	T25464	punct	.,created
R8013	T25498	T25499	nsubj	Visualization,aided
R8014	T25500	T25498	cc	and,Visualization
R8015	T25501	T25498	conj	color,Visualization
R8016	T25502	T25501	punct	-,color
R8017	T25503	T25501	amod	coding,color
R8018	T25504	T25498	prep	of,Visualization
R8019	T25505	T25504	pobj	genes,of
R8020	T25506	T25498	acl	using,Visualization
R8021	T25507	T25506	dobj	GenMAPP,using
R8022	T25508	T25509	det	the,selection
R8023	T25509	T25499	dobj	selection,aided
R8024	T25510	T25509	prep	of,selection
R8025	T25511	T25512	compound	candidate,genes
R8026	T25512	T25510	pobj	genes,of
R8027	T25513	T25512	acl	mapping,genes
R8028	T25514	T25513	prep	within,mapping
R8029	T25515	T25516	compound	QTL,regions
R8030	T25516	T25514	pobj	regions,within
R8031	T25517	T25516	prep	on,regions
R8032	T25518	T25519	nmod	MMU,2
R8033	T25519	T25517	pobj	2,on
R8034	T25520	T25519	punct	", ",2
R8035	T25521	T25519	conj	9,2
R8036	T25522	T25521	punct	", ",9
R8037	T25523	T25521	conj	11,9
R8038	T25524	T25523	cc	and,11
R8039	T25525	T25523	conj	17,11
R8040	T25526	T25499	punct	.,aided
R8043	T26350	T26351	compound	Candidate,gene
R8044	T26351	T26352	compound	gene,sequencing
R8045	T26354	T26355	compound	PCR,amplicons
R8046	T26355	T26356	nsubjpass	amplicons,amplified
R8047	T26357	T26355	acl	covering,amplicons
R8048	T26358	T26359	det	the,sequence
R8049	T26359	T26357	dobj	sequence,covering
R8050	T26360	T26359	compound	coding,sequence
R8051	T26361	T26355	cc	and,amplicons
R8052	T26362	T26363	amod	partial,regions
R8053	T26363	T26355	conj	regions,amplicons
R8054	T26364	T26363	nummod	5,regions
R8055	T26365	T26364	punct	',5
R8056	T26366	T26364	cc	and,5
R8057	T26367	T26364	conj	3,5
R8058	T26368	T26367	punct	',3
R8059	T26369	T26363	amod	untranslated,regions
R8060	T26370	T26363	prep	for,regions
R8061	T26371	T26372	det	each,gene
R8062	T26372	T26370	pobj	gene,for
R8063	T26373	T26372	amod	selected,gene
R8064	T26374	T26372	compound	candidate,gene
R8065	T26375	T26356	auxpass	were,amplified
R8066	T26376	T26356	punct	", ",amplified
R8067	T26377	T26356	conj	purified,amplified
R8068	T26378	T26377	cc	and,purified
R8069	T26379	T26377	conj	sequenced,purified
R8070	T26380	T26379	prep	from,sequenced
R8071	T26381	T26382	det	the,strain
R8072	T26382	T26380	pobj	strain,from
R8073	T26383	T26382	compound	CAST,strain
R8074	T26384	T26379	advcl	using,sequenced
R8075	T26385	T26384	dobj	protocols,using
R8076	T26386	T26385	acl	outlined,protocols
R8077	T26387	T26386	prep	in,outlined
R8078	T26388	T26389	punct	[,57
R8079	T26389	T26387	pobj	57,in
R8080	T26390	T26389	punct	],57
R8081	T26391	T26385	prep	with,protocols
R8082	T26392	T26393	amod	slight,modifications
R8083	T26393	T26391	pobj	modifications,with
R8084	T26394	T26356	punct	.,amplified
R8085	T26396	T26397	amod	Total,RNA
R8086	T26397	T26398	nsubjpass	RNA,isolated
R8087	T26399	T26397	prep	from,RNA
R8088	T26400	T26399	pobj	brain,from
R8089	T26401	T26400	punct	", ",brain
R8090	T26402	T26400	conj	liver,brain
R8091	T26403	T26402	punct	", ",liver
R8092	T26404	T26402	conj	spleen,liver
R8093	T26405	T26404	punct	", ",spleen
R8094	T26406	T26404	conj	lung,spleen
R8095	T26407	T26406	cc	and,lung
R8096	T26408	T26406	conj	testis,lung
R8097	T26409	T26398	auxpass	was,isolated
R8098	T26410	T26398	prep	from,isolated
R8099	T26411	T26412	det	an,mouse
R8100	T26412	T26410	pobj	mouse,from
R8101	T26413	T26412	amod	adult,mouse
R8102	T26414	T26412	nmod	CAST,mouse
R8103	T26415	T26412	amod	male,mouse
R8104	T26416	T26398	advcl	using,isolated
R8105	T26417	T26416	dobj	Trizol,using
R8106	T26418	T26419	punct	(,Ambion
R8107	T26419	T26417	parataxis	Ambion,Trizol
R8108	T26420	T26419	punct	),Ambion
R8109	T26421	T26398	punct	.,isolated
R8110	T26423	T26424	nsubjpass	cDNA,produced
R8111	T26425	T26424	auxpass	was,produced
R8112	T26426	T26424	prep	from,produced
R8113	T26427	T26428	amod	total,RNA
R8114	T26428	T26426	pobj	RNA,from
R8115	T26429	T26424	advcl	using,produced
R8116	T26430	T26431	amod	standard,procedures
R8117	T26431	T26429	dobj	procedures,using
R8118	T26432	T26424	punct	.,produced
R8119	T26434	T26435	compound	PCR,sets
R8120	T26435	T26437	nsubjpass	sets,designed
R8121	T26436	T26435	compound	primer,sets
R8122	T26438	T26435	prep	for,sets
R8123	T26439	T26440	det	each,gene
R8124	T26440	T26438	pobj	gene,for
R8125	T26441	T26437	auxpass	were,designed
R8126	T26442	T26437	advcl	using,designed
R8127	T26443	T26442	dobj	Primer3,using
R8128	T26444	T26445	punct	[,58
R8129	T26445	T26437	parataxis	58,designed
R8130	T26446	T26445	punct	],58
R8131	T26447	T26448	punct	(,File
R8132	T26448	T26437	parataxis	File,designed
R8133	T26449	T26448	amod	Additional,File
R8134	T26450	T26448	nummod	5,File
R8135	T26451	T26448	punct	),File
R8136	T26452	T26437	punct	.,designed
R8137	T26454	T26455	det	The,amplification
R8138	T26455	T26457	nsubjpass	amplification,performed
R8139	T26456	T26455	amod	initial,amplification
R8140	T26458	T26457	auxpass	was,performed
R8141	T26459	T26457	prep	in,performed
R8142	T26460	T26461	nummod	10,μl
R8143	T26461	T26462	compound	μl,reactions
R8144	T26462	T26459	pobj	reactions,in
R8145	T26463	T26462	compound	PCR,reactions
R8146	T26464	T26457	advcl	using,performed
R8147	T26465	T26466	det	the,system
R8148	T26466	T26464	dobj	system,using
R8149	T26467	T26466	compound	Invitrogen,system
R8150	T26468	T26466	compound	Platinum,system
R8151	T26469	T26470	compound	TaqPCRx,amplification
R8152	T26470	T26466	compound	amplification,system
R8153	T26471	T26472	punct	(,Invitrogen
R8154	T26472	T26466	parataxis	Invitrogen,system
R8155	T26473	T26472	punct	),Invitrogen
R8156	T26474	T26457	punct	.,performed
R8157	T26476	T26477	det	The,reactions
R8158	T26477	T26478	nsubj	reactions,contained
R8159	T26479	T26480	compound	1X,buffer
R8160	T26480	T26478	dobj	buffer,contained
R8161	T26481	T26480	compound	PCR,buffer
R8162	T26482	T26480	punct	", ",buffer
R8163	T26483	T26484	compound	1X,solution
R8164	T26484	T26480	conj	solution,buffer
R8165	T26485	T26484	compound	Enhancer,solution
R8166	T26486	T26484	punct	", ",solution
R8167	T26487	T26488	nummod	1.5,mM
R8168	T26488	T26489	compound	mM,MgSO4
R8169	T26489	T26484	conj	MgSO4,solution
R8170	T26490	T26489	punct	", ",MgSO4
R8171	T26491	T26492	nummod	0.17,mM
R8172	T26492	T26493	compound	mM,dNTPs
R8173	T26493	T26489	conj	dNTPs,MgSO4
R8174	T26494	T26493	punct	", ",dNTPs
R8175	T26495	T26496	nummod	1,μM
R8176	T26496	T26497	nmod	μM,primer
R8177	T26497	T26493	conj	primer,dNTPs
R8178	T26498	T26497	det	each,primer
R8179	T26499	T26497	punct	", ",primer
R8180	T26500	T26501	nummod	0.1,unit
R8181	T26501	T26497	conj	unit,primer
R8182	T26502	T26501	prep	of,unit
R8183	T26503	T26504	compound	Platinum,Taq
R8184	T26504	T26502	pobj	Taq,of
R8185	T26505	T26506	punct	(,Invitrogen
R8186	T26506	T26504	parataxis	Invitrogen,Taq
R8187	T26507	T26506	punct	),Invitrogen
R8188	T26508	T26501	cc	and,unit
R8189	T26509	T26510	advmod	approximately,25
R8190	T26510	T26511	nummod	25,ng
R8191	T26511	T26501	conj	ng,unit
R8192	T26512	T26511	prep	of,ng
R8193	T26513	T26512	pobj	cDNA,of
R8194	T26514	T26478	punct	.,contained
R8195	T26516	T26517	nsubjpass	Reactions,incubated
R8196	T26518	T26517	auxpass	were,incubated
R8197	T26519	T26517	prep	for,incubated
R8198	T26520	T26521	nummod	5,min
R8199	T26521	T26519	pobj	min,for
R8200	T26522	T26517	prep	at,incubated
R8201	T26523	T26524	nummod	95,°C
R8202	T26524	T26522	pobj	°C,at
R8203	T26525	T26517	punct	", ",incubated
R8204	T26526	T26527	advmod	then,cycled
R8205	T26527	T26517	dep	cycled,incubated
R8206	T26528	T26527	prep	for,cycled
R8207	T26529	T26530	nummod	45,s
R8208	T26530	T26528	pobj	s,for
R8209	T26531	T26530	prep	at,s
R8210	T26532	T26533	nummod	95,°C
R8211	T26533	T26531	pobj	°C,at
R8212	T26534	T26530	punct	", ",s
R8213	T26535	T26536	nummod	45,s
R8214	T26536	T26530	appos	s,s
R8215	T26537	T26536	prep	at,s
R8216	T26538	T26539	nummod	55,°C
R8217	T26539	T26537	pobj	°C,at
R8218	T26540	T26530	punct	", ",s
R8219	T26541	T26542	nummod	1,min
R8220	T26542	T26530	appos	min,s
R8221	T26543	T26542	prep	at,min
R8222	T26544	T26545	nummod	72,°C
R8223	T26545	T26543	pobj	°C,at
R8224	T26546	T26542	prep	for,min
R8225	T26547	T26548	nummod	35,cycles
R8226	T26548	T26546	pobj	cycles,for
R8227	T26549	T26527	prep	with,cycled
R8228	T26550	T26551	det	a,extension
R8229	T26551	T26549	pobj	extension,with
R8230	T26552	T26551	amod	final,extension
R8231	T26553	T26554	nummod	72,°C
R8232	T26554	T26551	compound	°C,extension
R8233	T26555	T26551	prep	for,extension
R8234	T26556	T26557	nummod	10,min
R8235	T26557	T26555	pobj	min,for
R8236	T26558	T26551	prep	on,extension
R8237	T26559	T26560	det	a,PTC
R8238	T26560	T26558	pobj	PTC,on
R8239	T26561	T26562	compound	MJ,Research
R8240	T26562	T26560	compound	Research,PTC
R8241	T26563	T26560	punct	-,PTC
R8242	T26564	T26560	nummod	200,PTC
R8243	T26565	T26517	punct	.,incubated
R8244	T26567	T26568	det	The,products
R8245	T26568	T26569	nsubjpass	products,visualized
R8246	T26570	T26569	auxpass	were,visualized
R8247	T26571	T26569	prep	on,visualized
R8248	T26572	T26573	nummod	1.5,%
R8249	T26573	T26574	compound	%,agarose
R8250	T26574	T26575	compound	agarose,gels
R8251	T26575	T26571	pobj	gels,on
R8252	T26576	T26575	acl	containing,gels
R8253	T26577	T26578	nummod	0.06,μg
R8254	T26578	T26579	nmod	μg,EtBr
R8255	T26579	T26576	dobj	EtBr,containing
R8256	T26580	T26581	punct	/,ml
R8257	T26581	T26578	prep	ml,μg
R8258	T26582	T26569	punct	.,visualized
R8259	T26584	T26585	nsubjpass	Bands,excised
R8260	T26586	T26584	prep	of,Bands
R8261	T26587	T26588	det	the,size
R8262	T26588	T26586	pobj	size,of
R8263	T26589	T26588	amod	correct,size
R8264	T26590	T26585	auxpass	were,excised
R8265	T26591	T26585	cc	and,excised
R8266	T26592	T26585	conj	incubated,excised
R8267	T26593	T26592	prep	in,incubated
R8268	T26594	T26595	nummod	100,μl
R8269	T26595	T26593	pobj	μl,in
R8270	T26596	T26595	prep	of,μl
R8271	T26597	T26598	amod	sterile,H2O
R8272	T26598	T26596	pobj	H2O,of
R8273	T26599	T26598	prep	at,H2O
R8274	T26600	T26601	nummod	80,°C
R8275	T26601	T26599	pobj	°C,at
R8276	T26602	T26592	prep	for,incubated
R8277	T26603	T26604	nummod	10,min
R8278	T26604	T26602	pobj	min,for
R8279	T26605	T26606	aux	to,elute
R8280	T26606	T26592	advcl	elute,incubated
R8281	T26607	T26606	dobj	DNA,elute
R8282	T26608	T26585	punct	.,excised
R8283	T26610	T26611	compound	Reamplification,reactions
R8284	T26611	T26612	nsubj	reactions,consisted
R8285	T26613	T26612	prep	of,consisted
R8286	T26614	T26615	compound	1X,buffer
R8287	T26615	T26613	pobj	buffer,of
R8288	T26616	T26615	compound	PCR,buffer
R8289	T26617	T26615	punct	", ",buffer
R8290	T26618	T26619	nummod	1.5,mM
R8291	T26619	T26620	compound	mM,MgCl2
R8292	T26620	T26615	conj	MgCl2,buffer
R8293	T26621	T26620	punct	", ",MgCl2
R8294	T26622	T26623	nummod	0.17,mM
R8295	T26623	T26624	compound	mM,dNTPs
R8296	T26624	T26620	conj	dNTPs,MgCl2
R8297	T26625	T26624	punct	", ",dNTPs
R8298	T26626	T26627	nummod	1,μM
R8299	T26627	T26628	nmod	μM,primer
R8300	T26628	T26624	conj	primer,dNTPs
R8301	T26629	T26628	det	each,primer
R8302	T26630	T26628	punct	", ",primer
R8303	T26631	T26632	nummod	0.1,unit
R8304	T26632	T26628	conj	unit,primer
R8305	T26633	T26632	prep	of,unit
R8306	T26634	T26633	pobj	Taq,of
R8307	T26635	T26636	punct	(,Promega
R8308	T26636	T26634	parataxis	Promega,Taq
R8309	T26637	T26636	punct	),Promega
R8310	T26638	T26632	cc	and,unit
R8311	T26639	T26640	nummod	10,μl
R8312	T26640	T26632	conj	μl,unit
R8313	T26641	T26640	prep	of,μl
R8314	T26642	T26641	pobj	eluate,of
R8315	T26643	T26615	prep	in,buffer
R8316	T26644	T26645	det	a,volume
R8317	T26645	T26643	pobj	volume,in
R8318	T26646	T26645	amod	total,volume
R8319	T26647	T26645	prep	of,volume
R8320	T26648	T26649	nummod	50,μl
R8321	T26649	T26647	pobj	μl,of
R8322	T26650	T26612	punct	.,consisted
R8323	T26652	T26653	det	The,parameters
R8324	T26653	T26656	nsubjpass	parameters,used
R8325	T26654	T26653	amod	same,parameters
R8326	T26655	T26653	compound	cycling,parameters
R8327	T26657	T26656	auxpass	were,used
R8328	T26658	T26656	prep	for,used
R8329	T26659	T26660	compound	reamplification,reactions
R8330	T26660	T26658	pobj	reactions,for
R8331	T26661	T26656	punct	.,used
R8332	T26663	T26664	nsubjpass	Products,visualized
R8333	T26665	T26664	auxpass	were,visualized
R8334	T26666	T26664	prep	on,visualized
R8335	T26667	T26668	nummod	1,%
R8336	T26668	T26669	compound	%,gels
R8337	T26669	T26666	pobj	gels,on
R8338	T26670	T26669	compound	0.5X,gels
R8339	T26671	T26669	compound	TBE,gels
R8340	T26672	T26669	compound	agarose,gels
R8341	T26673	T26669	acl	containing,gels
R8342	T26674	T26675	nummod	0.06,μg
R8343	T26675	T26676	nmod	μg,EtBr
R8344	T26676	T26673	dobj	EtBr,containing
R8345	T26677	T26678	punct	/,ml
R8346	T26678	T26675	prep	ml,μg
R8347	T26679	T26664	punct	", ",visualized
R8348	T26680	T26664	conj	excised,visualized
R8349	T26681	T26680	cc	and,excised
R8350	T26682	T26680	conj	purfied,excised
R8351	T26683	T26682	advcl	using,purfied
R8352	T26684	T26685	compound	PCR,purification
R8353	T26685	T26686	compound	purification,columns
R8354	T26686	T26683	dobj	columns,using
R8355	T26687	T26688	punct	(,Promega
R8356	T26688	T26686	parataxis	Promega,columns
R8357	T26689	T26688	punct	),Promega
R8358	T26690	T26664	punct	.,visualized
R8359	T26692	T26693	aux	To,quantity
R8360	T26693	T26694	advcl	quantity,run
R8361	T26695	T26696	det	each,fragment
R8362	T26696	T26693	dobj	fragment,quantity
R8363	T26697	T26698	nummod	1,μl
R8364	T26698	T26694	nsubjpass	μl,run
R8365	T26699	T26698	prep	of,μl
R8366	T26700	T26701	det	each,product
R8367	T26701	T26699	pobj	product,of
R8368	T26702	T26701	amod	purified,product
R8369	T26703	T26694	auxpass	was,run
R8370	T26704	T26694	prep	on,run
R8371	T26705	T26706	det	a,gel
R8372	T26706	T26704	pobj	gel,on
R8373	T26707	T26708	nummod	1.0,%
R8374	T26708	T26706	compound	%,gel
R8375	T26709	T26706	compound	agarose,gel
R8376	T26710	T26706	acl	containing,gel
R8377	T26711	T26712	nummod	0.06,μg
R8378	T26712	T26713	nmod	μg,EtBr
R8379	T26713	T26710	dobj	EtBr,containing
R8380	T26714	T26715	punct	/,ml
R8381	T26715	T26712	prep	ml,μg
R8382	T26716	T26706	punct	", ",gel
R8383	T26717	T26706	prep	along,gel
R8384	T26718	T26717	prep	with,along
R8385	T26719	T26720	det	a,ladder
R8386	T26720	T26718	pobj	ladder,with
R8387	T26721	T26720	compound	DNA,ladder
R8388	T26722	T26720	compound	mass,ladder
R8389	T26723	T26724	punct	(,Invitrogen
R8390	T26724	T26720	parataxis	Invitrogen,ladder
R8391	T26725	T26724	punct	),Invitrogen
R8392	T26726	T26694	punct	.,run
R8393	T26728	T26729	prep	In,added
R8394	T26730	T26731	det	a,plate
R8395	T26731	T26728	pobj	plate,In
R8396	T26732	T26733	nummod	96,well
R8397	T26733	T26731	compound	well,plate
R8398	T26734	T26729	punct	", ",added
R8399	T26735	T26736	nummod	15,ng
R8400	T26736	T26729	nsubjpass	ng,added
R8401	T26737	T26736	prep	of,ng
R8402	T26738	T26739	det	each,product
R8403	T26739	T26737	pobj	product,of
R8404	T26740	T26739	compound	PCR,product
R8405	T26741	T26729	auxpass	was,added
R8406	T26742	T26729	prep	to,added
R8407	T26743	T26744	nummod	5,pM
R8408	T26744	T26742	pobj	pM,to
R8409	T26745	T26744	prep	of,pM
R8410	T26746	T26745	pobj	primer,of
R8411	T26747	T26729	prep	for,added
R8412	T26748	T26747	pobj	sequencing,for
R8413	T26749	T26729	punct	.,added
R8414	T26751	T26752	det	The,College
R8415	T26752	T26753	nmod	College,Facility
R8416	T26753	T26763	nsubj	Facility,performed
R8417	T26754	T26752	prep	of,College
R8418	T26755	T26756	nmod	Agriculture,Sciences
R8419	T26756	T26754	pobj	Sciences,of
R8420	T26757	T26755	cc	and,Agriculture
R8421	T26758	T26755	conj	Environmental,Agriculture
R8422	T26759	T26752	punct	(,College
R8423	T26760	T26752	appos	CAES,College
R8424	T26761	T26753	punct	),Facility
R8425	T26762	T26753	compound	Genomics,Facility
R8426	T26764	T26753	prep	at,Facility
R8427	T26765	T26766	det	the,University
R8428	T26766	T26764	pobj	University,at
R8429	T26767	T26766	prep	of,University
R8430	T26768	T26767	pobj	California,of
R8431	T26769	T26766	punct	", ",University
R8432	T26770	T26766	npadvmod	Davis,University
R8433	T26771	T26763	punct	", ",performed
R8434	T26772	T26773	amod	bidirectional,sequencing
R8435	T26773	T26763	dobj	sequencing,performed
R8436	T26774	T26773	prep	of,sequencing
R8437	T26775	T26776	det	each,amplicon
R8438	T26776	T26774	pobj	amplicon,of
R8439	T26777	T26763	punct	.,performed
R8440	T26935	T26936	compound	Sequence,analysis
R8441	T26938	T26939	compound	B6,sequences
R8442	T26939	T26941	nsubjpass	sequences,downloaded
R8443	T26940	T26939	compound	mRNA,sequences
R8444	T26942	T26939	prep	for,sequences
R8445	T26943	T26944	det	each,gene
R8446	T26944	T26942	pobj	gene,for
R8447	T26945	T26941	auxpass	were,downloaded
R8448	T26946	T26941	prep	from,downloaded
R8449	T26947	T26948	det	the,assembly
R8450	T26948	T26946	pobj	assembly,from
R8451	T26949	T26948	nmod	May,assembly
R8452	T26950	T26949	nummod	2004,May
R8453	T26951	T26952	punct	(,mm5
R8454	T26952	T26948	parataxis	mm5,assembly
R8455	T26953	T26952	punct	),mm5
R8456	T26954	T26948	nmod	UCSC,assembly
R8457	T26955	T26956	punct	(,Build
R8458	T26956	T26948	parataxis	Build,assembly
R8459	T26957	T26956	compound	NCBI,Build
R8460	T26958	T26956	nummod	33,Build
R8461	T26959	T26956	punct	),Build
R8462	T26960	T26948	compound	genome,assembly
R8463	T26961	T26962	punct	[,28
R8464	T26962	T26941	parataxis	28,downloaded
R8465	T26963	T26962	punct	],28
R8466	T26964	T26941	punct	.,downloaded
R8467	T26966	T26967	det	These,sequences
R8468	T26967	T26968	nsubjpass	sequences,imported
R8469	T26969	T26968	auxpass	were,imported
R8470	T26970	T26968	prep	along,imported
R8471	T26971	T26970	prep	with,along
R8472	T26972	T26973	det	all,traces
R8473	T26973	T26971	pobj	traces,with
R8474	T26974	T26975	compound	CAST,sequence
R8475	T26975	T26973	compound	sequence,traces
R8476	T26976	T26968	prep	into,imported
R8477	T26977	T26978	det	the,program
R8478	T26978	T26976	pobj	program,into
R8479	T26979	T26978	compound	SeqMan,program
R8480	T26980	T26981	compound	sequence,assembly
R8481	T26981	T26978	compound	assembly,program
R8482	T26982	T26983	punct	(,DNASTAR
R8483	T26983	T26978	parataxis	DNASTAR,program
R8484	T26984	T26983	punct	),DNASTAR
R8485	T26985	T26968	cc	and,imported
R8486	T26986	T26987	advmod	manually,curated
R8487	T26987	T26968	conj	curated,imported
R8488	T26988	T26987	prep	for,curated
R8489	T26989	T26988	pobj	quality,for
R8490	T26990	T26968	punct	.,imported
R8491	T26992	T26993	amod	Poor,quality
R8492	T26993	T26994	compound	quality,reads
R8493	T26994	T26995	nsubjpass	reads,resequenced
R8494	T26996	T26995	auxpass	were,resequenced
R8495	T26997	T26995	punct	.,resequenced
R8496	T26999	T27000	amod	Individual,contigs
R8497	T27000	T27001	nsubjpass	contigs,created
R8498	T27002	T27001	auxpass	were,created
R8499	T27003	T27001	prep	for,created
R8500	T27004	T27005	det	each,gene
R8501	T27005	T27003	pobj	gene,for
R8502	T27006	T27001	cc	and,created
R8503	T27007	T27008	nsubjpass	polymorphisms,detected
R8504	T27008	T27001	conj	detected,created
R8505	T27009	T27008	auxpass	were,detected
R8506	T27010	T27008	cc	and,detected
R8507	T27011	T27008	conj	curated,detected
R8508	T27012	T27011	prep	by,curated
R8509	T27013	T27014	amod	manual,inspection
R8510	T27014	T27012	pobj	inspection,by
R8511	T27015	T27008	punct	.,detected
R1132	T4080	T4081	npadvmod	Speed,congenic
R1133	T4081	T4082	amod	congenic,strain
R1134	T4082	T4083	compound	strain,development
R1135	T4085	T4086	nummod	Two,panels
R1139	T4090	T4089	auxpass	were,created
R1140	T4091	T4089	punct	", ",created
R1141	T4092	T4093	det	the,first
R1142	T4093	T4094	nsubj	first,dissected
R1145	T4096	T4094	dobj	MMU2,dissected
R1146	T4097	T4098	mark	while,isolated
R1150	T4101	T4098	dobj	QTL,isolated
R1151	T4102	T4098	prep	on,isolated
R1152	T4103	T4104	nmod	MMU,1
R1153	T4104	T4102	pobj	1,on
R1154	T4105	T4104	punct	", ",1
R1155	T4106	T4104	conj	5,1
R1156	T4107	T4106	punct	", ",5
R1157	T4108	T4106	conj	8,5
R1158	T4109	T4108	punct	", ",8
R1159	T4110	T4108	conj	9,8
R1160	T4111	T4110	punct	", ",9
R1161	T4112	T4110	conj	11,9
R1162	T4113	T4112	cc	and,11
R1163	T4114	T4112	conj	17,11
R1164	T4115	T4116	punct	(,Table
R1165	T4116	T4098	parataxis	Table,isolated
R1166	T4117	T4116	nummod	1,Table
R1167	T4118	T4116	punct	),Table
R1168	T4119	T4089	punct	.,created
R1169	T4121	T4122	det	The,panel
R1172	T4125	T4124	prep	of,consisted
R1173	T4126	T4127	nummod	eight,strains
R1176	T4129	T4127	acl	developed,strains
R1177	T4130	T4129	prep	by,developed
R1178	T4131	T4130	pcomp	introgressing,by
R1179	T4132	T4133	nummod	four,regions
R1183	T4136	T4131	prep	onto,introgressing
R1184	T4137	T4138	preconj	both,B6
R1185	T4138	T4139	nmod	B6,backgrounds
R1190	T4143	T4144	punct	(,Table
R1191	T4144	T4129	parataxis	Table,developed
R1192	T4145	T4144	nummod	1,Table
R1193	T4146	T4144	punct	),Table
R1194	T4147	T4124	punct	.,consisted
R1195	T4149	T4150	amod	Single,regions
R1198	T4153	T4150	acl	bred,regions
R1199	T4154	T4153	prep	onto,bred
R1200	T4155	T4156	det	an,background
R1203	T4158	T4152	auxpass	were,created
R1204	T4159	T4160	aux	to,isolate
R1205	T4160	T4152	advcl	isolate,created
R1206	T4161	T4162	det	the,QTL
R1209	T4164	T4162	prep	on,QTL
R1210	T4165	T4166	nmod	MMU,1
R1211	T4166	T4164	pobj	1,on
R1212	T4167	T4166	punct	", ",1
R1213	T4168	T4166	conj	5,1
R1214	T4169	T4168	punct	", ",5
R1215	T4170	T4168	conj	8,5
R1216	T4171	T4170	punct	", ",8
R1217	T4172	T4170	conj	9,8
R1218	T4173	T4172	punct	", ",9
R1219	T4174	T4172	conj	11,9
R1220	T4175	T4174	cc	and,11
R1221	T4176	T4174	conj	17,11
R1222	T4177	T4152	punct	.,created
R1223	T4179	T4180	nsubj	Implementation,accelerated
R1224	T4181	T4179	prep	of,Implementation
R1225	T4182	T4183	det	a,approach
R1229	T4186	T4179	acl	using,Implementation
R1230	T4187	T4188	npadvmod	marker,assisted
R1233	T4190	T4186	dobj	breeding,using
R1234	T4191	T4186	prep	with,using
R1235	T4192	T4193	nummod	79,markers
R1238	T4195	T4193	amod	wide,markers
R1241	T4198	T4180	dobj	production,accelerated
R1242	T4199	T4198	prep	of,production
R1243	T4200	T4201	det	all,strains
R1244	T4201	T4199	pobj	strains,of
R1245	T4202	T4203	punct	[,6
R1249	T4206	T4203	punct	],6
R1250	T4207	T4208	punct	(,File
R1253	T4210	T4208	nummod	1,File
R1254	T4211	T4208	cc	and,File
R1255	T4212	T4208	conj	Figure,File
R1256	T4213	T4212	nummod	1,Figure
R1257	T4214	T4208	punct	),File
R1258	T4215	T4180	punct	.,accelerated
R1259	T4217	T4218	compound	Strain,abbreviations
R1260	T4218	T4219	nsubjpass	abbreviations,listed
R1261	T4220	T4218	cc	and,abbreviations
R1262	T4221	T4222	amod	genomic,region
R1263	T4222	T4218	conj	region,abbreviations
R1264	T4223	T4222	acl	isolated,region
R1265	T4224	T4223	prep	by,isolated
R1266	T4225	T4226	det	each,strain
R1267	T4226	T4224	pobj	strain,by
R1268	T4227	T4219	auxpass	are,listed
R1269	T4228	T4219	prep	in,listed
R1270	T4229	T4228	pobj	Table,in
R1271	T4230	T4229	nummod	1,Table
R1272	T4231	T4219	punct	.,listed
R1273	T4233	T4234	prep	In,developed
R1274	T4235	T4233	pobj	addition,In
R1275	T4236	T4235	prep	to,addition
R1276	T4237	T4238	preconj	both,panels
R1279	T4240	T4234	punct	", ",developed
R1280	T4241	T4242	nummod	two,strains
R1283	T4244	T4245	amod	homozygous,B6
R1284	T4245	T4242	appos	B6,strains
R1285	T4246	T4245	punct	(,B6
R1286	T4247	T4248	nmod	B6.CASTC,B6C
R1289	T4250	T4245	punct	),B6
R1290	T4251	T4245	cc	or,B6
R1291	T4252	T4245	conj	HG,B6
R1292	T4253	T4252	punct	(,HG
R1293	T4254	T4255	nmod	HG.CASTC,HGC
R1296	T4257	T4245	punct	),B6
R1297	T4258	T4245	prep	for,B6
R1298	T4259	T4260	det	all,markers
R1301	T4262	T4260	amod	wide,markers
R1303	T4264	T4242	acl	genotyped,strains
R1304	T4265	T4234	auxpass	were,developed
R1305	T4266	T4234	prep	from,developed
R1306	T4267	T4268	det	the,cross
R1309	T4270	T4234	punct	(,developed
R1310	T4271	T4234	xcomp	see,developed
R1311	T4272	T4271	dobj	Methods,see
R1312	T4273	T4234	punct	),developed
R1313	T4274	T4234	cc	and,developed
R1314	T4275	T4234	conj	served,developed
R1315	T4276	T4275	prep	as,served
R1316	T4277	T4278	det	the,basis
R1317	T4278	T4276	pobj	basis,as
R1318	T4279	T4278	prep	for,basis
R1319	T4280	T4281	compound	strain,comparisons
R1320	T4281	T4279	pobj	comparisons,for
R1321	T4282	T4234	punct	.,developed
R1322	T4284	T4285	prep	After,characterized
R1323	T4286	T4284	pcomp	stabilizing,After
R1324	T4287	T4288	det	each,congenic
R1325	T4288	T4286	dobj	congenic,stabilizing
R1326	T4289	T4285	punct	", ",characterized
R1327	T4290	T4291	quantmod	12,14
R1330	T4293	T4285	auxpass	were,characterized
R1331	T4294	T4285	advmod	phenotypically,characterized
R1332	T4295	T4285	prep	for,characterized
R1333	T4296	T4295	pobj	growth,for
R1334	T4297	T4296	cc	and,growth
R1335	T4298	T4296	conj	adiposity,growth
R1336	T4299	T4285	punct	.,characterized
R1337	T4301	T4302	det	The,strains
R1342	T4307	T4306	auxpass	were,characterized
R1343	T4308	T4306	neg	not,characterized
R1344	T4309	T4306	prep	due,characterized
R1345	T4310	T4309	pcomp	to,due
R1346	T4311	T4312	amod	reproductive,problems
R1347	T4312	T4309	pobj	problems,due
R1348	T4313	T4306	punct	.,characterized
R1349	T4315	T4316	det	The,points
R1353	T4320	T4316	prep	for,points
R1354	T4321	T4322	det	all,strains
R1355	T4322	T4320	pobj	strains,for
R1356	T4323	T4319	auxpass	were,refined
R1357	T4324	T4319	advcl	using,refined
R1358	T4325	T4326	compound	microsatellite,markers
R1359	T4326	T4324	dobj	markers,using
R1360	T4327	T4326	acl	flanking,markers
R1361	T4328	T4329	det	each,region
R1364	T4331	T4332	punct	(,File
R1367	T4334	T4332	nummod	2,File
R1368	T4335	T4332	punct	),File
R1369	T4336	T4319	punct	.,refined
R2	T576	T574	punct	-,wide
R6	T581	T579	cc	and,growth
R7	T582	T579	conj	obesity,growth
R16	T595	T593	punct	(,growth
R17	T596	T593	appos	hg,growth
R18	T597	T594	punct	),modifier
R23	T603	T604	amod	quantitative,trait
R24	T604	T602	compound	trait,loci
R76	T658	T657	punct	/,EiJ
R78	T660	T657	punct	(,EiJ
R79	T661	T657	appos	CAST,EiJ
R80	T662	T659	punct	),alleles
R81	T663	T659	compound	QTL,alleles
R85	T667	T666	nmod	mutant,hg
R86	T668	T666	nmod	C57Bl,hg
R87	T669	T666	punct	/,hg
R88	T670	T666	nmod	6J,hg
R89	T671	T666	punct	-,hg
R90	T672	T666	nmod	hg,hg
R91	T673	T666	punct	/,hg
R93	T675	T676	punct	(,HG
R94	T676	T666	parataxis	HG,hg
R95	T677	T676	punct	),HG
R96	T678	T666	cc	or,hg
R97	T679	T680	amod	wild,type
R98	T680	T666	conj	type,hg
R99	T681	T682	compound	C57Bl,6J
R102	T684	T685	punct	(,B6
R103	T685	T680	parataxis	B6,type
R104	T686	T685	punct	),B6
R105	T687	T674	amod	genetic,backgrounds
R109	T694	T693	amod	first,panel
R110	T695	T696	npadvmod	speed,congenic
R111	T696	T693	amod	congenic,panel
R117	T703	T702	amod	overlapping,regions
R118	T704	T702	compound	donor,regions
R128	T714	T712	cc	and,HG
R129	T715	T712	conj	B6,HG
R143	T731	T730	compound	MMU2,panel
R150	T738	T736	cc	and,growth
R151	T739	T736	conj	obesity,growth
R157	T745	T746	det	a,subset
R158	T746	T744	nsubj	subset,modify
R159	T747	T746	prep	of,subset
R160	T748	T749	det	these,loci
R161	T749	T747	pobj	loci,of
R167	T755	T754	compound	hg,deletion
R171	T760	T759	amod	second,panel
R175	T765	T764	compound	donor,regions
R179	T769	T768	compound	HG,background
R200	T792	T791	nummod	six,strains
R201	T793	T791	amod	developed,strains
R247	T841	T840	punct	-,specific
R252	T849	T850	npadvmod	speed,congenic
R253	T850	T848	amod	congenic,strains
R258	T856	T855	amod	invaluable,resource
R259	T857	T855	amod	genomic,resource
R268	T866	T865	amod	specific,nature
R6630	T21658	T21677	nsubjpass	males,genotyped
R278	T2716	T2717	det	The,use
R279	T2717	T2718	nsubj	use,provided
R280	T2719	T2717	prep	of,use
R281	T2720	T2721	compound	mouse,models
R282	T2721	T2719	pobj	models,of
R283	T2722	T2718	aux	has,provided
R284	T2723	T2724	amod	valuable,insight
R285	T2724	T2718	dobj	insight,provided
R286	T2725	T2724	prep	into,insight
R287	T2726	T2727	det	the,etiology
R288	T2727	T2725	pobj	etiology,into
R289	T2728	T2727	prep	of,etiology
R290	T2729	T2730	amod	monogenic,syndromes
R291	T2730	T2728	pobj	syndromes,of
R292	T2731	T2730	acl	caused,syndromes
R293	T2732	T2731	agent	by,caused
R294	T2733	T2734	amod	single,mutations
R297	T2736	T2718	punct	.,provided
R298	T2738	T2739	advmod	However,mimic
R299	T2740	T2739	punct	", ",mimic
R300	T2741	T2742	amod	such,models
R301	T2742	T2739	nsubj	models,mimic
R302	T2743	T2739	aux	do,mimic
R303	T2744	T2739	neg	not,mimic
R304	T2745	T2746	det	the,complexity
R307	T2748	T2746	prep	of,complexity
R308	T2749	T2750	compound	disease,traits
R309	T2750	T2748	pobj	traits,of
R310	T2751	T2752	advmod	commonly,seen
R311	T2752	T2750	acl	seen,traits
R312	T2753	T2752	prep	in,seen
R313	T2754	T2755	det	the,population
R316	T2757	T2739	punct	.,mimic
R317	T2759	T2760	compound	Complex,traits
R318	T2760	T2761	nsubjpass	traits,influenced
R319	T2762	T2760	punct	", ",traits
R320	T2763	T2764	amod	such,as
R321	T2764	T2760	prep	as,traits
R322	T2765	T2766	amod	polygenic,growth
R323	T2766	T2764	pobj	growth,as
R324	T2767	T2766	cc	and,growth
R325	T2768	T2766	conj	obesity,growth
R326	T2769	T2761	auxpass	are,influenced
R327	T2770	T2761	agent	by,influenced
R328	T2771	T2772	det	the,effects
R334	T2777	T2772	prep	of,effects
R335	T2778	T2779	amod	quantitative,loci
R338	T2781	T2779	punct	(,loci
R339	T2782	T2779	appos	QTL,loci
R340	T2783	T2779	punct	),loci
R341	T2784	T2779	punct	", ",loci
R342	T2785	T2779	conj	epistasis,loci
R343	T2786	T2785	prep	between,epistasis
R344	T2787	T2788	compound	QTL,alleles
R345	T2788	T2786	pobj	alleles,between
R346	T2789	T2785	punct	", ",epistasis
R347	T2790	T2791	amod	environmental,perturbations
R348	T2791	T2785	conj	perturbations,epistasis
R349	T2792	T2791	cc	and,perturbations
R350	T2793	T2794	compound	QTL,environment
R353	T2796	T2791	conj	interactions,perturbations
R354	T2797	T2761	punct	.,influenced
R355	T2799	T2800	prep	To,localized
R366	T2811	T2812	punct	[,2
R370	T2815	T2812	punct	],2
R371	T2816	T2810	punct	", ",made
R372	T2817	T2810	advmod	however,made
R373	T2818	T2810	punct	", ",made
R374	T2819	T2820	amod	little,progress
R375	T2820	T2810	nsubjpass	progress,made
R376	T2821	T2810	aux	has,made
R377	T2822	T2810	auxpass	been,made
R378	T2823	T2810	prep	in,made
R379	T2824	T2823	pcomp	determining,in
R380	T2825	T2826	det	the,nature
R383	T2828	T2826	prep	of,nature
R384	T2829	T2830	det	the,variants
R388	T2833	T2810	punct	.,made
R389	T2835	T2836	nummod	One,resource
R390	T2836	T2837	nsubj	resource,are
R391	T2838	T2836	acl	used,resource
R392	T2839	T2840	aux	to,map
R395	T2842	T2840	dobj	QTL,map
R396	T2843	T2844	amod	congenic,strains
R397	T2844	T2837	attr	strains,are
R589	T3050	T3051	det	a,array
R592	T3053	T3051	prep	of,array
R593	T3054	T3053	pobj	traits,of
R594	T3055	T3051	punct	", ",array
R612	T3070	T3068	nmod	hg,mouse
R670	T3135	T3126	relcl	shared,mouse
R671	T3136	T3137	det	a,number
R672	T3137	T3135	dobj	number,shared
R673	T3138	T3137	prep	of,number
R956	T3439	T3421	auxpass	were,identified
R957	T3440	T3421	punct	", ",identified
R958	T3441	T3421	prep	along,identified
R959	T3442	T3441	prep	with,along
R960	T3443	T3444	nummod	12,QTL
R1081	T3570	T3571	det	the,presence
R1082	T3571	T3569	dobj	presence,confirm
R1083	T3572	T3571	prep	of,presence
R1084	T3573	T3574	amod	multiple,QTL
R1085	T3574	T3572	pobj	QTL,of
R1086	T3575	T3569	cc	and,confirm
R1087	T3576	T3569	conj	test,confirm
R1088	T3577	T3576	prep	for,test
R1089	T3578	T3579	compound	QTL,hg
R1092	T3581	T3577	pobj	interactions,for
R1093	T3582	T3566	punct	.,developed
R1094	T3584	T3585	advmod	Additionally,sequenced
R1095	T3586	T3585	punct	", ",sequenced
R1096	T3587	T3585	prep	based,sequenced
R1097	T3588	T3587	prep	on,based
R1098	T3589	T3590	det	the,knowledge
R1099	T3590	T3588	pobj	knowledge,on
R1100	T3591	T3590	prep	of,knowledge
R1101	T3592	T3593	amod	potential,interactions
R1104	T3595	T3593	compound	hg,interactions
R1106	T3597	T3585	punct	", ",sequenced
R1107	T3598	T3585	nsubjpass	genes,sequenced
R1108	T3599	T3598	acl	involved,genes
R1109	T3600	T3599	prep	in,involved
R1110	T3601	T3602	compound	Gh,signaling
R1111	T3602	T3600	pobj	signaling,in
R1112	T3603	T3598	punct	", ",genes
R1113	T3604	T3605	poss	whose,location
R1116	T3607	T3598	relcl	overlapped,genes
R1117	T3608	T3609	compound	hg,QTL
R1120	T3611	T3609	prep	on,QTL
R1121	T3612	T3613	nmod	MMU,2
R1122	T3613	T3611	pobj	2,on
R1123	T3614	T3613	punct	", ",2
R1124	T3615	T3613	conj	9,2
R1125	T3616	T3615	punct	", ",9
R1126	T3617	T3615	conj	11,9
R1127	T3618	T3617	cc	and,11
R1128	T3619	T3617	conj	17,11
R1129	T3620	T3585	punct	", ",sequenced
R1130	T3621	T3585	auxpass	were,sequenced
R1131	T3622	T3585	punct	.,sequenced
R3225	T11708	T11705	punct	),ash
R3226	T11709	T11705	cc	and,ash
R3227	T11710	T11711	compound	carcass,protein
R3574	T12083	T12082	det	the,increase
R3575	T12084	T12085	nummod	16.5,%
R3576	T12085	T12082	compound	%,increase
R3578	T12086	T12082	prep	in,increase
R3579	T12087	T12086	pobj	AI,in
R3582	T12089	T12090	punct	(,Table
R3583	T12090	T12079	parataxis	Table,was
R3584	T12091	T12090	nummod	5,Table
R3585	T12092	T12090	punct	),Table
R3671	T12184	T12182	conj	ASH,H2O
R3932	T12470	T12469	nsubj	P,0.005
R3933	T12471	T12469	punct	<,0.005
R3935	T12472	T12460	punct	.,were
R3936	T12474	T12475	prep	In,possessed
R1656	T7259	T7234	conj	decreases,decreases
R1667	T7262	T7260	pobj	length,in
R1917	T7539	T7540	punct	(,GFP
R1918	T7540	T7537	parataxis	GFP,gonadal
R1919	T7541	T7540	punct	),GFP
R2259	T7907	T7908	advmod	Therefore,impacted
R2263	T7911	T7908	nsubjpass	QTL,impacted
R2344	T7999	T8000	compound	HG,genotype
R2612	T8287	T8288	mark	although,reached
R2617	T8292	T8288	dobj	significance,reached
R5155	T18627	T18626	punct	-,hg
R5157	T18628	T18629	nsubj	epistasis,implies
R6112	T19710	T19705	attr	genes,are
R6118	T19714	T19715	compound	hg,modifier
R6120	T19715	T19710	compound	modifier,genes
R6121	T19716	T19710	compound	candidate,genes
R6122	T19717	T19705	cc	and,are
R6124	T19718	T19719	det	this,information
R6125	T19719	T19720	nsubjpass	information,incorporated
R6127	T19720	T19705	conj	incorporated,are
R6128	T19721	T19720	aux	can,incorporated
R6129	T19722	T19720	auxpass	be,incorporated
R6130	T19723	T19720	prep	into,incorporated
R6131	T19724	T19725	amod	future,studies
R6133	T19725	T19723	pobj	studies,into
R6134	T19726	T19727	amod	fine,mapping
R6135	T19727	T19725	compound	mapping,studies
R6136	T19728	T19720	punct	.,incorporated

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T545	0-6	SO_EXT:0001026	denotes	Genome
T546	25-31	GO_EXT:biological_growth_entity_or_process	denotes	growth
T547	44-47	SO_EXT:0000771	denotes	QTL
T548	54-59	NCBITaxon:10088	denotes	mouse
T549	109-115	GO_EXT:biological_growth_entity_or_process	denotes	growth
T550	157-180	SO_EXT:0000771	denotes	quantitative trait loci
T551	182-185	SO_EXT:0000771	denotes	QTL
T552	197-203	GO_EXT:biological_growth_entity_or_process	denotes	growth
T553	219-226	UBERON:0008979	denotes	carcass
T554	269-274	NCBITaxon:10088	denotes	mouse
T555	275-286	GO_SO_EXT:chromosome	denotes	chromosomes
T556	288-291	NCBITaxon:10090	denotes	MMU
T557	360-363	SO_EXT:0000771	denotes	QTL
T558	450-453	SO_EXT:0000771	denotes	QTL
T559	454-461	SO_EXT:0001023	denotes	alleles
T560	474-480	SO_EXT:sequence_altered_entity_or_alteration_process	denotes	mutant
T561	504-513	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T562	528-535	SO_EXT:0000704	denotes	genetic
T563	828-834	GO_EXT:biological_growth_entity_or_process	denotes	growth
T564	847-850	SO_EXT:0000771	denotes	QTL
T565	931-939	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T566	1025-1028	SO_EXT:0000771	denotes	QTL
T567	1166-1172	GO_EXT:biological_growth_entity_or_process	denotes	growth
T568	1290-1293	SO_EXT:0000771	denotes	QTL
T569	1474-1481	SO_EXT:0001026	denotes	genomic
T570	1553-1560	SO_EXT:0000704	denotes	genetic
T571	1561-1570	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T572	1583-1589	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2618	1626-1631	NCBITaxon:10088	denotes	mouse
T2619	1694-1699	SO_EXT:0000704	denotes	genic
T2620	1727-1731	SO_EXT:0000704	denotes	gene
T2621	1732-1741	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T2622	1781-1788	SO_EXT:0000704	denotes	genetic
T2623	1839-1844	NCBITaxon:9606	denotes	human
T2624	1885-1890	SO_EXT:0000704	denotes	genic
T2625	1891-1897	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2626	1968-1991	SO_EXT:0000771	denotes	quantitative trait loci
T2627	1993-1996	SO_EXT:0000771	denotes	QTL
T2628	2017-2020	SO_EXT:0000771	denotes	QTL
T2629	2021-2028	SO_EXT:0001023	denotes	alleles
T2630	2062-2065	SO_EXT:0000771	denotes	QTL
T2631	2109-2114	NCBITaxon:10088	denotes	mouse
T2632	2115-2121	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2633	2134-2137	SO_EXT:0000771	denotes	QTL
T2634	2257-2264	SO_EXT:0000704	denotes	genetic
T2635	2265-2273	SO_EXT:sequence_variant_entity	denotes	variants
T2636	2305-2308	SO_EXT:0000771	denotes	QTL
T2637	2374-2379	SO_EXT:0000704	denotes	genic
T2638	2417-2422	SO_EXT:0000704	denotes	genic
T2639	2472-2479	SO_EXT:0000704	denotes	genetic
T2640	2480-2489	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T2641	2616-2627	SO_EXT:0000704	denotes	genetically
T2642	2638-2642	NCBITaxon:10088	denotes	mice
T2643	2764-2767	SO_EXT:0000771	denotes	QTL
T2644	2836-2839	SO_EXT:0000771	denotes	QTL
T2645	2840-2847	SO_EXT:0001023	denotes	alleles
T2646	2901-2916	SO_EXT:0001645	denotes	genetic markers
T2647	2909-2916	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T2648	2925-2932	SO_EXT:0000704	denotes	genetic
T2649	3274-3280	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T2650	3312-3316	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T2651	3317-3321	NCBITaxon:10088	denotes	mice
T2652	3345-3352	SO_EXT:0001023	denotes	alleles
T2653	3495-3500	NCBITaxon:10088	denotes	mouse
T2654	3501-3504	SO_EXT:0000771	denotes	QTL
T2655	3543-3549	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2656	3594-3599	NCBITaxon:10088	denotes	mouse
T2657	3627-3633	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2658	3663-3671	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T2659	3699-3709	GO:0010467	denotes	expression
T2660	3717-3722	PR_EXT:000015393	denotes	Socs2
T2661	3724-3758	PR_EXT:000015393	denotes	suppressor of cytokine signaling 2
T2662	3738-3746	GO_EXT:0005125	denotes	cytokine
T2663	3738-3756	GO:0019221	denotes	cytokine signaling
T2664	3760-3764	SO_EXT:0000704	denotes	gene
T2665	3786-3791	PR_EXT:000015393	denotes	Socs2
T2666	3857-3862	PR_EXT:000015393	denotes	Socs2
T2667	3862-3863	SO_EXT:sequence_nullness_or_absence	denotes	-
T2668	3864-3865	SO_EXT:sequence_nullness_or_absence	denotes	-
T2669	3875-3880	NCBITaxon:10088	denotes	mouse
T2670	3962-3965	SO_EXT:0000771	denotes	QTL
T2671	4046-4049	SO_EXT:0000771	denotes	QTL
T2672	4065-4068	SO_EXT:0000771	denotes	QTL
T2673	4131-4139	SO_EXT:sequence_alteration_process	denotes	modified
T2674	4167-4171	SO_EXT:0000704	denotes	gene
T2675	4220-4228	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T2676	4356-4360	SO_EXT:0000704	denotes	gene
T2677	4403-4414	CHEBI_EXT:biochemical	denotes	biochemical
T2678	4418-4427	GO:0008152	denotes	metabolic
T2679	4447-4454	SO_EXT:0000704	denotes	genetic
T2680	4497-4503	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2681	4567-4572	PR_EXT:000015393	denotes	Socs2
T2682	4579-4598	GO_EXT:negative_regulation	denotes	negatively regulate
T2683	4599-4605	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2684	4599-4613	CHEBI_GO_PR_EXT:growth_hormone	denotes	growth hormone
T2685	4615-4617	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T2686	4681-4693	SO_EXT:polymorphism	denotes	polymorphism
T2687	4742-4744	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T2688	4742-4762	GO:0060396	denotes	Gh signaling pathway
T2689	4847-4860	GO:0008152	denotes	metabolically
T2690	4953-4959	GO_EXT:biological_growth_entity_or_process	denotes	growth
T2691	4964-4971	UBERON:0008979	denotes	carcass
T2692	4984-4987	SO_EXT:0000771	denotes	QTL
T2693	5063-5067	NCBITaxon:10088	denotes	mice
T2694	5090-5098	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T2695	5111-5120	SO_EXT:wild_type_entity_or_quality	denotes	wild type
T2696	5122-5123	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2697	5124-5125	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2698	5156-5159	SO_EXT:0000771	denotes	QTL
T2699	5199-5200	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2700	5201-5202	SO_EXT:normal_or_wild_type_or_present	denotes	+
T2701	5203-5207	NCBITaxon:10088	denotes	mice
T2702	5254-5258	SO_EXT:0000704	denotes	gene
T2703	5308-5311	SO_EXT:0000771	denotes	QTL
T2704	5420-5423	SO_EXT:0000771	denotes	QTL
T2705	5650-5660	GO:0010467	denotes	expression
T2706	5790-5793	SO_EXT:0000771	denotes	QTL
T2707	5852-5870	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal region
T2708	6088-6091	SO_EXT:0000771	denotes	QTL
T2709	6105-6108	SO_EXT:0000771	denotes	QTL
T2710	6176-6179	SO_EXT:0000771	denotes	QTL
T2711	6197-6202	SO_EXT:0000704	denotes	genes
T2712	6215-6217	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T2713	6215-6227	GO:0060396	denotes	Gh signaling
T2714	6235-6242	SO_EXT:0001026	denotes	genomic
T2715	6275-6278	SO_EXT:0000771	denotes	QTL
T4062	6469-6472	SO_EXT:0000771	denotes	QTL
T4063	6641-6648	SO_EXT:0000704	denotes	genetic
T4064	6693-6697	GO_EXT:breeding	denotes	bred
T4065	6758-6761	SO_EXT:0000771	denotes	QTL
T4066	6841-6847	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T4067	6857-6865	GO_EXT:breeding	denotes	breeding
T4068	6874-6880	SO_EXT:0001026	denotes	genome
T4069	6886-6900	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T4070	6901-6908	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4071	7012-7019	SO_EXT:0001026	denotes	genomic
T4072	7191-7197	SO_EXT:0001026	denotes	genome
T4073	7203-7210	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4074	7398-7404	GO_EXT:biological_growth_entity_or_process	denotes	growth
T4075	7475-7487	GO:0000003	denotes	reproductive
T4076	7502-7513	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T4077	7560-7574	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T4078	7575-7582	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T4079	7583-7591	SO:0000357	denotes	flanking
T6835	7743-7762	GO_SO_EXT:chromosomal_part_or_position_or_region_or_site	denotes	chromosomal regions
T6836	7810-7813	SO_EXT:0000771	denotes	QTL
T6837	7928-7935	SO_EXT:0000704	denotes	genetic
T6838	8200-8204	UBERON_EXT:body	denotes	body
T6839	8371-8375	NCBITaxon:10088	denotes	mice
T6840	8415-8419	UBERON_EXT:body	denotes	body
T6841	8446-8452	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6842	8639-8645	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6843	8646-8649	SO_EXT:0000771	denotes	QTL
T6844	8662-8670	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6845	8716-8720	UBERON_EXT:body	denotes	body
T6846	8775-8781	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6847	8850-8854	NCBITaxon:10088	denotes	mice
T6848	8887-8891	UBERON:0002415	denotes	tail
T6849	8925-8929	UBERON:0000004	denotes	naso
T6850	8930-8934	UBERON:0001245	denotes	anal
T6851	8976-8980	NCBITaxon:10088	denotes	mice
T6852	9010-9014	UBERON_EXT:body	denotes	body
T6853	9027-9033	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6854	9035-9039	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T6855	9061-9067	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T6856	9142-9146	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T6857	9163-9167	UBERON:0002415	denotes	tail
T6858	9235-9239	NCBITaxon:10088	denotes	mice
T6859	9335-9339	NCBITaxon:10088	denotes	mice
T6860	9421-9424	SO_EXT:0000771	denotes	QTL
T6861	9532-9536	UBERON_EXT:body	denotes	body
T6862	9548-9552	UBERON:0002415	denotes	tail
T6863	9583-9586	SO_EXT:0000771	denotes	QTL
T6864	9685-9688	SO_EXT:0000771	denotes	QTL
T6865	9722-9729	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T6866	9751-9757	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6867	9827-9832	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T6868	9875-9882	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T6869	9891-9896	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T6870	10004-10010	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T6871	10020-10026	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6872	10027-10030	SO_EXT:0000771	denotes	QTL
T6873	10060-10066	SO_EXT:0001026	denotes	genome
T6874	10072-10076	UBERON_EXT:body	denotes	body
T6875	10077-10080	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6876	10109-10117	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T6877	10159-10166	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T6878	10213-10216	SO_EXT:0000771	denotes	QTL
T6879	10336-10339	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6880	10336-10343	UBERON:0003916	denotes	fat pad
T6881	10423-10430	_FRAGMENT	denotes	gonadal
T6882	10496-10504	UBERON:0003428	denotes	fat pads
T6883	10432-10435	UBERON:0003428	denotes	GFP
T6884	10438-10445	_FRAGMENT	denotes	femoral
T6885	10496-10504	UBERON:0012283	denotes	fat pads
T6886	10447-10450	UBERON:0012283	denotes	FFP
T6887	10453-10463	_FRAGMENT	denotes	mesenteric
T6888	10496-10504	UBERON:0015143	denotes	fat pads
T6889	10465-10468	UBERON:0015143	denotes	MFP
T6890	10474-10489	_FRAGMENT	denotes	retroperitoneal
T6891	10496-10504	UBERON:0010411	denotes	fat pads
T6892	10491-10494	UBERON:0010411	denotes	RFP
T6893	10496-10499	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6894	10523-10526	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6895	10523-10530	UBERON:0003916	denotes	fat pad
T6896	10555-10558	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6897	10555-10563	UBERON:0003916	denotes	fat pads
T6898	10601-10610	GO_EXT:killing	denotes	sacrifice
T6899	10623-10627	UBERON_EXT:body	denotes	body
T6900	10724-10728	UBERON_EXT:body	denotes	body
T6901	10951-10955	NCBITaxon:10088	denotes	mice
T6902	11007-11010	SO_EXT:0000771	denotes	QTL
T6903	11094-11097	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6904	11094-11101	UBERON:0003916	denotes	fat pad
T6905	11216-11220	NCBITaxon:10088	denotes	mice
T6906	11283-11287	UBERON_EXT:body	denotes	body
T6907	11300-11306	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6908	11430-11434	NCBITaxon:10088	denotes	mice
T6909	11469-11472	SO_EXT:0000771	denotes	QTL
T6910	11541-11545	UBERON_EXT:body	denotes	body
T6911	11580-11587	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T6912	11598-11601	SO_EXT:0000771	denotes	QTL
T6913	11645-11649	UBERON:0002415	denotes	tail
T6914	11669-11675	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6915	11705-11708	UBERON:0003428	denotes	GFP
T6916	11710-11713	UBERON:0015143	denotes	MFP
T6917	11715-11718	UBERON:0010411	denotes	RFP
T6918	11758-11762	NCBITaxon:10088	denotes	mice
T6919	11855-11861	GO_EXT:biological_growth_entity_or_process	denotes	growth
T6920	11862-11865	SO_EXT:0000771	denotes	QTL
T6921	11919-11923	NCBITaxon:10088	denotes	mice
T6922	11973-11978	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Males
T6923	12091-12098	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T6924	12167-12170	SO_EXT:0000771	denotes	QTL
T6925	12272-12275	SO_EXT:0000771	denotes	QTL
T6926	12389-12392	SO_EXT:0000771	denotes	QTL
T6927	12423-12431	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6928	12504-12511	SO_EXT:0000704	denotes	genetic
T6929	12529-12530	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6930	12531-12532	SO_EXT:normal_or_wild_type_or_present	denotes	+
T6931	12603-12611	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6932	12660-12663	SO_EXT:0000771	denotes	QTL
T6933	12690-12697	SO_EXT:0001026	denotes	genomic
T6934	12751-12755	SO_EXT:0000704	denotes	gene
T6935	12888-12892	NCBITaxon:10088	denotes	mice
T6936	13095-13098	SO_EXT:0000771	denotes	QTL
T6937	13123-13125	SO_EXT:0000028	denotes	bp
T6938	13304-13312	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6939	13378-13382	NCBITaxon:10088	denotes	mice
T6940	13455-13459	NCBITaxon:10088	denotes	mice
T6941	13495-13503	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6942	13653-13659	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T6943	13684-13688	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T6944	13723-13726	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T6945	13794-13802	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6946	13838-13846	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6947	13963-13971	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T6948	14267-14270	SO_EXT:0000771	denotes	QTL
T6949	14300-14308	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T10953	14338-14341	SO_EXT:0000771	denotes	QTL
T10954	14426-14429	SO_EXT:0000771	denotes	QTL
T10955	14568-14572	NCBITaxon:10088	denotes	mice
T10956	14602-14608	GO_EXT:biological_growth_entity_or_process	denotes	growth
T10957	14667-14671	UBERON:0002415	denotes	tail
T10958	14682-14689	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T10959	14804-14808	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T10960	14809-14812	UBERON:0015143	denotes	MFP
T10961	14895-14898	SO_EXT:0000771	denotes	QTL
T10962	14924-14927	SO_EXT:0000771	denotes	QTL
T10963	14991-14997	SO_EXT:0001026	denotes	genome
T10964	15010-15017	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	Markers
T10965	15085-15088	SO_EXT:0000771	denotes	QTL
T10966	15175-15179	NCBITaxon:10088	denotes	mice
T10967	15198-15204	GO_EXT:biological_growth_entity_or_process	denotes	growth
T10968	15288-15293	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T10969	15316-15319	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T10970	15316-15323	UBERON:0003916	denotes	fat pad
T10971	15368-15371	UBERON:0015143	denotes	MFP
T10972	15413-15417	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T10973	15489-15492	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T10974	15515-15522	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T10975	15564-15567	UBERON:0003428	denotes	GFP
T10976	15569-15572	UBERON:0015143	denotes	MFP
T10977	15595-15598	UBERON:0010411	denotes	RFP
T10978	15692-15696	NCBITaxon:10088	denotes	mice
T10979	15743-15750	SO_EXT:0001023	denotes	alleles
T10980	15767-15770	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T10981	15795-15802	SO_EXT:0001023	denotes	alleles
T10982	15889-15893	UBERON_EXT:body	denotes	body
T10983	15894-15897	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T10984	15927-15932	UBERON:0000981	denotes	femur
T10985	15998-16001	SO_EXT:0000771	denotes	QTL
T10986	16140-16143	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T10987	16189-16194	UBERON:0000981	denotes	femur
T10988	16277-16281	NCBITaxon:10088	denotes	mice
T10989	16317-16321	NCBITaxon:10088	denotes	mice
T10990	16330-16333	UBERON:0015143	denotes	MFP
T10991	16359-16364	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T10992	16379-16384	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T10993	16386-16389	UBERON:0003428	denotes	GFP
T10994	16391-16394	UBERON:0010411	denotes	RFP
T10995	16396-16399	UBERON:0012283	denotes	FFP
T10996	16473-16480	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T10997	16602-16609	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T10998	16640-16644	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T10999	16649-16655	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T11000	16773-16778	UBERON:0000981	denotes	femur
T11001	16804-16808	NCBITaxon:10088	denotes	mice
T11002	16864-16867	SO_EXT:0000771	denotes	QTL
T11003	17079-17086	SO_EXT:0001023	denotes	alleles
T11004	17144-17151	UBERON:0008979	denotes	carcass
T11005	17166-17173	UBERON:0008979	denotes	carcass
T11006	17174-17181	CHEBI_PR_EXT:protein	denotes	protein
T11007	17183-17187	CHEBI_PR_EXT:protein	denotes	PROT
T11008	17223-17230	UBERON:0008979	denotes	carcass
T11009	17247-17255	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T11010	17454-17458	NCBITaxon:10088	denotes	mice
T11011	17496-17502	GO_EXT:biological_growth_entity_or_process	denotes	growth
T11012	17546-17551	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11013	17583-17590	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11014	17612-17618	GO_EXT:biological_growth_entity_or_process	denotes	growth
T11015	17801-17806	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11016	17832-17836	UBERON:0002415	denotes	tail
T11017	17900-17907	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11018	17978-17981	SO_EXT:0000771	denotes	QTL
T11019	18056-18062	GO_EXT:biological_growth_entity_or_process	denotes	growth
T11020	18173-18178	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11021	18197-18204	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11022	18316-18324	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T11023	18325-18330	CHEBI:18059	denotes	lipid
T11024	18355-18358	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11025	18355-18362	UBERON:0003916	denotes	fat pad
T11026	18404-18411	UBERON:0008979	denotes	carcass
T11027	18412-18415	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11028	18417-18420	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T11029	18448-18455	UBERON:0008979	denotes	carcass
T11030	18479-18489	UBERON:0000468	denotes	total body
T11031	18501-18507	UBERON:0000062	denotes	organs
T11032	18519-18523	UBERON:0000033	denotes	head
T11033	18528-18550	UBERON:0001555	denotes	gastrointestinal tract
T11034	18554-18557	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T11035	18573-18581	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	chemical
T11036	18698-18701	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11037	18698-18705	UBERON:0003916	denotes	fat pad
T11038	18753-18763	UBERON:0000468	denotes	whole body
T11039	18830-18833	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11040	18859-18863	UBERON_EXT:body	denotes	body
T11041	18878-18885	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11042	18920-18923	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11043	18920-18928	UBERON:0003916	denotes	fat pads
T11044	18937-18940	UBERON:0015143	denotes	MFP
T11045	19035-19040	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11046	19070-19073	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11047	19207-19210	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11048	19207-19214	UBERON:0003916	denotes	fat pad
T11049	19224-19230	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T11050	19236-19245	UBERON:0008979	denotes	carcasses
T11051	19272-19275	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T11052	19292-19296	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T11053	19297-19306	UBERON:0008979	denotes	carcasses
T11054	19325-19332	UBERON:0008979	denotes	carcass
T11055	19374-19380	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T11056	19381-19390	UBERON:0008979	denotes	carcasses
T11057	19417-19420	CHEBI:15377	denotes	H2O
T11058	19500-19503	CHEBI:15377	denotes	H2O
T11059	19506-19509	CHEBI:15377	denotes	H2O
T11060	19512-19515	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T11061	19525-19529	CHEBI_PR_EXT:protein	denotes	PROT
T11062	19697-19703	UBERON:0000479	denotes	tissue
T11063	19719-19724	CHEBI:18059	denotes	lipid
T11064	19741-19748	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11065	19786-19791	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11066	19846-19849	SO_EXT:0000771	denotes	QTL
T11067	19910-19917	SO_EXT:0001023	denotes	alleles
T11068	19927-19934	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T11069	19969-19974	UBERON:0000981	denotes	femur
T11070	19991-19995	CHEBI_PR_EXT:protein	denotes	PROT
T11071	20039-20043	NCBITaxon:10088	denotes	mice
T11072	20092-20097	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11073	20111-20118	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11074	20218-20224	GO_EXT:biological_growth_entity_or_process	denotes	growth
T11075	20281-20285	NCBITaxon:10088	denotes	mice
T11076	20362-20366	NCBITaxon:10088	denotes	mice
T11077	20416-20421	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T11078	20426-20433	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T11079	20472-20476	UBERON:0002415	denotes	tail
T11080	20551-20555	NCBITaxon:10088	denotes	mice
T11081	20583-20586	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T11082	20583-20591	UBERON:0003916	denotes	fat pads
T11083	20600-20603	UBERON:0015143	denotes	MFP
T11084	20720-20724	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T11085	20725-20734	UBERON:0008979	denotes	carcasses
T11086	20761-20764	CHEBI:15377	denotes	H2O
T11087	20780-20786	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	female
T11088	20787-20796	UBERON:0008979	denotes	carcasses
T11089	20825-20828	CHEBI:15377	denotes	H2O
T11090	20845-20849	CHEBI_PR_EXT:protein	denotes	PROT
T13214	20903-20907	SO_EXT:0000704	denotes	gene
T13215	20950-20958	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T13216	20962-20967	PR_EXT:000015393	denotes	Socs2
T13217	20996-20999	SO_EXT:0000771	denotes	QTL
T13218	21061-21070	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T13219	21078-21083	SO_EXT:0000704	denotes	genes
T13220	21120-21122	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T13221	21153-21158	SO_EXT:0000704	denotes	genes
T13222	21188-21193	SO_EXT:0000704	denotes	genes
T13223	21233-21235	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T13224	21233-21245	GO:0060396	denotes	Gh signaling
T13225	21265-21267	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T13226	21297-21299	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T13227	21344-21349	SO_EXT:0000704	denotes	genes
T13228	21452-21456	SO_EXT:0000704	denotes	Gene
T13229	21528-21541	SO_EXT:coding_sequence	denotes	coding region
T13230	21550-21554	SO_EXT:0000704	denotes	gene
T13231	21632-21640	SO_EXT:biological_sequence	denotes	sequence
T13232	21653-21666	SO_EXT:polymorphism	denotes	polymorphisms
T13233	21707-21709	SO_EXT:0000028	denotes	bp
T13234	21733-21735	SO_EXT:0000028	denotes	bp
T13235	21752-21754	SO_EXT:0000028	denotes	bp
T13236	21755-21757	_FRAGMENT	denotes	5'
T13237	21765-21784	SO_EXT:0000204	denotes	untranslated region
T13238	21786-21789	SO_EXT:0000204	denotes	UTR
T13239	21762-21784	SO_EXT:0000205	denotes	3' untranslated region
T13240	21762-21764	_FRAGMENT	denotes	3'
T13241	21786-21789	SO_EXT:0000205	denotes	UTR
T13242	21767-21777	GO:0006412	denotes	translated
T13243	21813-21824	CHEBI_SO_EXT:amino_acid	denotes	amino acids
T13244	21856-21864	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T13245	21928-21934	SO_EXT:0001026	denotes	genome
T13246	21935-21943	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T13247	22023-22036	SO_EXT:polymorphism	denotes	polymorphisms
T13248	22077-22108	SO_EXT:0000694	denotes	single nucleotide polymorphisms
T13249	22084-22094	CHEBI_SO_EXT:nucleotide	denotes	nucleotide
T13250	22110-22113	SO_EXT:0000694	denotes	SNP
T13251	22127-22137	SO_EXT:sequence_insertion_entity_or_process	denotes	insertions
T13252	22141-22150	SO_EXT:sequence_deletion_entity_or_process	denotes	deletions
T13253	22187-22197	SO_EXT:sequence_insertion_entity_or_process	denotes	insertions
T13254	22201-22210	SO_EXT:sequence_deletion_entity_or_process	denotes	deletions
T13255	22231-22233	_FRAGMENT	denotes	5'
T13256	22241-22245	SO_EXT:0000204	denotes	UTRs
T13257	22238-22245	SO_EXT:0000205	denotes	3' UTRs
T13258	22257-22270	SO:0001816	denotes	nonsynonomous
T13259	22271-22274	SO_EXT:0000694	denotes	SNP
T13260	22315-22320	SO_EXT:0000704	denotes	genes
T13261	22443-22450	CHEBI_PR_EXT:protein	denotes	protein
T13262	22474-22499	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionary conservation
T13263	22512-22522	CHEBI_SO_EXT:amino_acid	denotes	amino acid
T13264	22523-22531	CHEBI_EXT:residue	denotes	residues
T13265	22549-22557	SO_EXT:biological_sequence	denotes	sequence
T13266	22571-22578	CHEBI_PR_EXT:protein	denotes	protein
T13267	22579-22588	SO_EXT:biological_sequence	denotes	sequences
T13268	22589-22599	SO:0000857	denotes	homologous
T13269	22724-22729	SO_EXT:0000704	denotes	genes
T13270	22751-22758	CHEBI_PR_EXT:protein	denotes	protein
T17479	22876-22879	SO_EXT:0000771	denotes	QTL
T17480	22908-22917	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T17481	22918-22925	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17482	22979-22985	SO_EXT:0001026	denotes	genome
T17483	23020-23026	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17484	23031-23038	UBERON:0008979	denotes	carcass
T17485	23051-23054	SO_EXT:0000771	denotes	QTL
T17486	23256-23259	SO_EXT:0000771	denotes	QTL
T17487	23324-23327	SO_EXT:0000771	denotes	QTL
T17488	23437-23441	NCBITaxon:10088	denotes	mice
T17489	23503-23510	SO_EXT:0000704	denotes	genetic
T17490	23536-23541	SO_EXT:sequence_cloning_process	denotes	clone
T17491	23551-23575	SO_EXT:0000771	denotes	quantitative trait genes
T17492	23643-23646	SO_EXT:0000771	denotes	QTL
T17493	23678-23685	SO_EXT:0001023	denotes	alleles
T17494	23841-23848	SO_EXT:0001023	denotes	alleles
T17495	23971-23975	NCBITaxon:10088	denotes	mice
T17496	24081-24084	SO_EXT:0000771	denotes	QTL
T17497	24088-24097	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T17498	24236-24242	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17499	24255-24258	SO_EXT:0000771	denotes	QTL
T17500	24337-24344	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17501	24353-24356	SO_EXT:0000771	denotes	QTL
T17502	24455-24462	SO_EXT:0001023	denotes	alleles
T17503	24480-24483	SO_EXT:0000771	denotes	QTL
T17504	24508-24511	SO_EXT:0000771	denotes	QTL
T17580	28369-28386	GO_EXT:0004871	denotes	signal transducer
T17505	24512-24518	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	Marker
T17506	24598-24601	SO_EXT:0000771	denotes	QTL
T17507	24630-24637	CHEBI:16236	denotes	ethanol
T17508	24664-24671	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17509	24672-24680	SO:0000357	denotes	flanking
T17510	24681-24684	SO_EXT:0000771	denotes	QTL
T17511	24701-24707	SO_EXT:0001026	denotes	genome
T17512	24713-24720	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T17513	24770-24773	SO_EXT:0000771	denotes	QTL
T17514	24796-24802	SO_EXT:0001026	denotes	genome
T17515	24883-24890	SO_EXT:0000704	denotes	genetic
T17516	24891-24900	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T17517	25000-25007	SO_EXT:0000704	denotes	genetic
T17518	25048-25056	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T17519	25067-25075	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T17520	25187-25195	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T17521	25207-25213	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17522	25260-25265	NCBITaxon:10088	denotes	mouse
T17523	25399-25406	SO_EXT:0001026	denotes	genomic
T17524	25579-25586	SO_EXT:0001023	denotes	alleles
T17525	25647-25655	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T17526	25687-25693	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17527	25706-25709	SO_EXT:0000771	denotes	QTL
T17528	25719-25722	SO_EXT:0000771	denotes	QTL
T17529	25816-25819	SO_EXT:0000771	denotes	QTL
T17530	25980-25985	SO_EXT:0000704	denotes	genes
T17531	25996-26002	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17532	26083-26093	GO_SO_EXT:chromosome	denotes	chromosome
T17533	26184-26187	SO_EXT:0000771	denotes	QTL
T17534	26273-26279	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17535	26362-26365	SO_EXT:0000771	denotes	QTL
T17536	26449-26452	SO_EXT:0000771	denotes	QTL
T17537	26472-26482	GO:0010467	denotes	expression
T17538	26492-26495	SO_EXT:0000771	denotes	QTL
T17539	26575-26581	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17540	26665-26668	SO_EXT:0000771	denotes	QTL
T17541	26693-26696	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T17542	26809-26814	CHEBI:18059	denotes	lipid
T17543	26809-26822	GO:0019915	denotes	lipid storage
T17544	26860-26864	NCBITaxon:10088	denotes	mice
T17545	26870-26877	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T17546	26900-26905	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T17547	26941-26945	NCBITaxon:10088	denotes	mice
T17548	26981-26984	SO_EXT:0000771	denotes	QTL
T17549	27123-27126	SO_EXT:0000771	denotes	QTL
T17550	27303-27306	SO_EXT:0000771	denotes	QTL
T17551	27337-27340	SO_EXT:0000771	denotes	QTL
T17552	27374-27380	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17553	27399-27403	NCBITaxon:10088	denotes	mice
T17554	27416-27419	SO_EXT:0000771	denotes	QTL
T17555	27489-27493	SO_EXT:0000704	denotes	gene
T17556	27495-27498	SO_EXT:0000771	denotes	QTL
T17557	27525-27530	PR_EXT:000015393	denotes	Socs2
T17558	27568-27578	CHEBI_GO_EXT:biological_process_or_quality_or_role	denotes	biological
T17559	27605-27608	SO_EXT:0000771	denotes	QTL
T17560	27627-27639	SO_EXT:polymorphism	denotes	polymorphism
T17561	27643-27648	SO_EXT:0000704	denotes	genes
T17562	27666-27668	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17563	27684-27686	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17564	27708-27716	GO:0065007	denotes	modulate
T17565	27717-27719	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17566	27770-27773	SO_EXT:0000771	denotes	QTL
T17567	27774-27781	SO_EXT:sequence_cloning_process	denotes	cloning
T17568	27832-27839	SO_EXT:sequence_cloning_process	denotes	Cloning
T17569	27846-27849	SO_EXT:0000771	denotes	QTL
T17570	27905-27907	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17571	27916-27936	GO:0040008	denotes	regulation of growth
T17572	27980-27985	NCBITaxon:9606	denotes	human
T17573	27986-27988	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17574	28007-28011	NCBITaxon:10088	denotes	mice
T17575	28042-28048	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17576	28185-28188	SO_EXT:0000771	denotes	QTL
T17577	28217-28220	SO_EXT:0000771	denotes	QTL
T17578	28290-28294	NCBITaxon:10088	denotes	mice
T17579	28323-28328	SO_EXT:0000704	denotes	genes
T17581	28369-28419	PR_EXT:000002087	denotes	signal transducer and activator of transcription 1
T17582	28404-28417	GO_EXT:transcription	denotes	transcription
T17583	28421-28426	PR_EXT:000002087	denotes	Stat1
T17584	28432-28437	PR_EXT:000002090	denotes	Stat4
T17585	28503-28517	UBERON:0001013	denotes	adipose tissue
T17586	28581-28588	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T17587	28670-28675	NCBITaxon:10088	denotes	mouse
T17588	28784-28791	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T17589	28810-28815	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T17590	28857-28867	GO:0010467	denotes	expression
T17591	28925-28930	NCBITaxon:10088	denotes	mouse
T17592	29010-29020	GO:0065007	denotes	modulation
T17593	29024-29038	UBERON:0001013	denotes	adipose tissue
T17594	29053-29055	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17595	29114-29122	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T17596	29226-29239	GO_PATO_EXT:physiological_process_or_quality	denotes	physiological
T17597	29276-29280	CHEBI_EXT:33290	denotes	food
T17598	29276-29287	GO:0007631	denotes	food intake
T17599	29292-29299	PR_EXT:000045358	denotes	insulin
T17600	29401-29405	NCBITaxon:10088	denotes	mice
T17601	29482-29487	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Males
T17602	29518-29525	GO:0040007	denotes	growing
T17603	29566-29573	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T17604	29675-29681	SO_EXT:0001026	denotes	genome
T17605	29811-29816	SO_EXT:0000704	denotes	genes
T17606	29841-29843	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17607	29841-29843	_FRAGMENT	denotes	Gh
T17608	29858-29875	GO:0060396	denotes	signaling pathway
T17609	29844-29857	GO:0005622	denotes	intracellular
T17610	29844-29875	GO:0030522	denotes	intracellular signaling pathway
T17611	29849-29857	CL_GO_EXT:cell	denotes	cellular
T17612	29885-29887	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17613	29889-29895	PR_EXT:000002092	denotes	Stat5b
T17614	29900-29906	PR_EXT:000002091	denotes	Stat5a
T17615	29923-29929	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17616	29930-29933	SO_EXT:0000771	denotes	QTL
T17617	30011-30016	NCBITaxon:10088	denotes	mouse
T17618	30089-30091	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17619	30092-30101	GO_EXT:secretion_entity_or_process	denotes	secretion
T17620	30106-30108	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17621	30117-30121	SO_EXT:0000704	denotes	gene
T17622	30117-30132	GO:0010467	denotes	gene expression
T17623	30177-30185	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T17624	30223-30227	SO_EXT:0000704	denotes	gene
T17625	30238-30240	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17626	30286-30288	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17627	30289-30293	SO_EXT:0000704	denotes	gene
T17628	30305-30311	PR_EXT:000002092	denotes	Stat5b
T17629	30360-30362	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17630	30377-30389	SO_EXT:polymorphism	denotes	polymorphism
T17631	30402-30409	CHEBI_PR_EXT:protein	denotes	protein
T17632	30437-30442	PR_EXT:000015393	denotes	Socs2
T17633	30458-30473	GO_EXT:transcription	denotes	transcriptional
T17634	30476-30486	GO:0065007	denotes	regulation
T17635	30490-30492	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17636	30532-30538	PR_EXT:000002092	denotes	Stat5b
T17637	30587-30591	NCBITaxon:10088	denotes	mice
T17638	30616-30629	GO_EXT:transcription	denotes	transcription
T17639	30616-30636	GO_EXT:transcription_factor	denotes	transcription factor
T17640	30653-30655	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17641	30677-30682	UBERON:0002107	denotes	liver
T17642	30683-30687	SO_EXT:0000704	denotes	gene
T17643	30683-30698	GO:0010467	denotes	gene expression
T17644	30809-30811	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17645	30816-30822	PR_EXT:000002092	denotes	Stat5b
T17646	30823-30831	SO_EXT:biological_sequence	denotes	sequence
T17647	30836-30846	GO:0010467	denotes	expression
T17648	30868-30872	NCBITaxon:10088	denotes	mice
T17649	30890-30893	SO_EXT:0000771	denotes	QTL
T17650	30946-30952	GO_EXT:biological_growth_entity_or_process	denotes	growth
T17651	30954-30958	UBERON_EXT:body	denotes	body
T17652	30970-30977	UBERON:0008979	denotes	carcass
T17653	31020-31024	SO_EXT:0000704	denotes	gene
T17654	31052-31057	PR_EXT:000001672	denotes	Sstr5
T17655	31059-31071	CHEBI_PR_EXT:somatostatin	denotes	Somatostatin
T17656	31084-31093	CHEBI_EXT:35222	denotes	inhibitor
T17657	31097-31099	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17658	31104-31109	PR_EXT:000001672	denotes	Sstr5
T17659	31125-31134	GO_EXT:0004872	denotes	receptors
T17660	31187-31197	UBERON:0001264	denotes	pancreatic
T17661	31187-31207	CL:0000169	denotes	pancreatic beta cell
T17662	31203-31207	CL_GO_EXT:cell	denotes	cell
T17663	31229-31234	PR_EXT:000001672	denotes	Sstr5
T17664	31259-31266	PR_EXT:000045358	denotes	insulin
T17665	31267-31276	GO_EXT:secretion_entity_or_process	denotes	secretion
T17666	31281-31288	CHEBI:17234	denotes	glucose
T17667	31281-31300	GO:0042593	denotes	glucose homeostasis
T17668	31345-31350	SO_EXT:0000704	denotes	genes
T17669	31476-31485	SO_EXT:sequence_variation_entity_or_quality	denotes	variation
T17670	31498-31513	SO_EXT:coding_sequence	denotes	coding sequence
T17671	31580-31583	SO_EXT:0000694	denotes	SNP
T17672	31597-31612	SO_EXT:coding_sequence	denotes	coding sequence
T17673	31711-31715	SO_EXT:0000704	denotes	gene
T17674	31711-31726	GO:0010467	denotes	gene expression
T17675	31746-31749	SO_EXT:0000694	denotes	SNP
T17676	31773-31776	SO_EXT:0000694	denotes	SNP
T17677	31788-31790	SO_EXT:0000028	denotes	bp
T17678	31800-31805	SO_EXT:0000704	denotes	genes
T17679	31857-31860	CHEBI_SO_EXT:DNA	denotes	DNA
T17680	31941-31949	SO_EXT:biological_sequence	denotes	sequence
T17681	31968-31976	SO_EXT:biological_sequence	denotes	sequence
T17682	32022-32026	SO_EXT:0000704	denotes	gene
T17683	32022-32037	GO:0010467	denotes	gene expression
T17684	32069-32079	GO:0010467	denotes	expression
T17685	32113-32118	SO_EXT:0000704	denotes	genes
T17686	32257-32270	SO:0001816	denotes	nonsynonomous
T17687	32271-32283	SO_EXT:polymorphism	denotes	polymorphism
T17688	32304-32307	SO_EXT:0000771	denotes	QTL
T17689	32355-32362	CHEBI_PR_EXT:protein	denotes	protein
T17690	32431-32436	SO_EXT:0000704	denotes	genes
T17691	32506-32531	SO_EXT:biological_conservation_process_or_quality	denotes	evolutionary conservation
T17692	32613-32618	SO_EXT:0000704	denotes	genes
T17693	32620-32624	PR_EXT:000017012	denotes	Ubr1
T17694	32626-32632	PR_EXT:000001968	denotes	Ptpns1
T17695	32634-32642	PR_EXT:000017005	denotes	Ubce7ip5
T17696	32647-32651	PR_EXT:000010491	denotes	Mmp9
T17697	32733-32738	PR_EXT:000015393	denotes	Socs2
T17698	32751-32799	GO:0043161	denotes	ubiquitination dependent proteasomal degradation
T17699	32776-32787	GO:0000502	denotes	proteasomal
T17700	32811-32813	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T17701	32811-32823	GO:0060396	denotes	Gh signaling
T17702	32830-32834	PR_EXT:000017012	denotes	Ubr1
T17703	32839-32847	PR_EXT:000017005	denotes	Ubce7ip5
T17704	32869-32876	CHEBI_PR_EXT:protein	denotes	protein
T17705	32869-32891	GO:0016567	denotes	protein ubiquitination
T17706	32896-32900	PR_EXT:000017012	denotes	Ubr1
T17707	32910-32914	NCBITaxon:10088	denotes	mice
T17708	32939-32943	UBERON_EXT:body	denotes	body
T17709	32980-32994	UBERON:0001013	denotes	adipose tissue
T17710	33004-33010	PR_EXT:000001968	denotes	Ptpns1
T17711	33020-33024	NCBITaxon:10088	denotes	mice
T17712	33054-33058	UBERON_EXT:body	denotes	body
T17713	33075-33079	PR_EXT:000010491	denotes	Mmp9
T17714	33089-33093	NCBITaxon:10088	denotes	mice
T17715	33143-33147	UBERON_EXT:bone_element_or_tissue	denotes	bone
T17716	33174-33179	SO_EXT:0000704	denotes	genes
T17717	33242-33247	SO_EXT:0000704	denotes	genes
T19886	33409-33415	SO_EXT:0001026	denotes	genome
T19887	33421-33424	SO_EXT:0000771	denotes	QTL
T19888	33435-33441	GO_EXT:biological_growth_entity_or_process	denotes	growth
T19889	33455-33462	UBERON:0008979	denotes	carcass
T19890	33549-33552	SO_EXT:0000771	denotes	QTL
T19891	33661-33670	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T19892	33684-33687	SO_EXT:0000771	denotes	QTL
T19893	33790-33799	CHEBI_EXT:polyatomic_entity_or_group	denotes	molecular
T19894	33800-33807	SO_EXT:0000704	denotes	genetic
T19895	33824-33830	GO_EXT:biological_growth_entity_or_process	denotes	growth
T20221	33854-33859	NCBITaxon:10088	denotes	Mouse
T20222	33907-33911	NCBITaxon:10088	denotes	mice
T20223	33963-33971	SO_EXT:sequence_alteration_entity_or_process	denotes	mutation
T20224	34127-34131	NCBITaxon:10088	denotes	mice
T20225	34210-34214	NCBITaxon:10088	denotes	Mice
T20226	34230-34243	CHEBI_EXT:polycarbonate	denotes	polycarbonate
T20227	34482-34488	NCBITaxon:33208	denotes	Animal
T20749	34516-34519	CHEBI_SO_EXT:DNA	denotes	DNA
T20750	34564-34568	UBERON:0002415	denotes	tail
T20751	34593-34603	GO_EXT:0008233	denotes	Proteinase
T20752	34628-34634	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T20753	34653-34657	CHEBI:63016	denotes	NP40
T20754	34673-34681	CHEBI:53424	denotes	Tween 20
T20755	34702-34708	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T20756	34780-34783	CHEBI:15377	denotes	H2O
T20757	34838-34852	SO_EXT:microsatellite_unit_or_region	denotes	Microsatellite
T20758	34961-34967	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	marker
T20759	35021-35025	NCBITaxon:10088	denotes	mice
T20760	35060-35066	SO_EXT:0000112	denotes	primer
T20761	35089-35095	SO_EXT:0000112	denotes	primer
T20762	35104-35105	SO:0001030	denotes	F
T20763	35134-35135	SO:0001031	denotes	R
T20764	35174-35182	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T20765	35199-35201	SO_EXT:0000028	denotes	bp
T20766	35223-35224	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20767	35228-35232	NCBITaxon:10088	denotes	mice
T20768	35257-35258	SO:0001030	denotes	F
T20769	35292-35293	SO:0001031	denotes	R
T20770	35333-35335	SO_EXT:0000028	denotes	bp
T20771	35336-35341	PR_EXT:000005845	denotes	Cradd
T20772	35374-35382	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T20773	35387-35388	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20774	35389-35390	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20775	35395-35396	SO_EXT:normal_or_wild_type_or_present	denotes	+
T20776	35400-35404	NCBITaxon:10088	denotes	mice
T20777	35419-35428	GO:0097617	denotes	annealing
T20778	35458-35463	CHEBI:6636	denotes	MgCl2
T21570	35642-35646	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21571	35654-35661	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T21572	35680-35684	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	Male
T21573	35688-35692	NCBITaxon:10088	denotes	mice
T21574	35721-35728	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T21575	35796-35798	SO_EXT:0000028	denotes	bp
T21576	35811-35816	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21577	35839-35853	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T21578	35854-35861	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T21579	35889-35896	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T21580	35927-35933	SO_EXT:0001026	denotes	genome
T21581	35988-35991	SO_EXT:0000771	denotes	QTL
T21582	36052-36056	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21583	36082-36088	SO_EXT:0001026	denotes	genome
T21584	36141-36148	SO_EXT:0001023	denotes	alleles
T21585	36162-36169	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T21586	36187-36195	GO_EXT:breeding	denotes	breeding
T21587	36258-36262	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T21588	36303-36310	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T21589	36367-36374	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T21590	36376-36387	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T21591	36388-36393	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21592	36484-36495	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T21593	36496-36501	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T21594	36542-36549	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T21595	36584-36585	SO_EXT:normal_or_wild_type_or_present	denotes	+
T21596	36586-36587	SO_EXT:normal_or_wild_type_or_present	denotes	+
T21597	36636-36640	NCBITaxon:10088	denotes	mice
T21598	36651-36656	GO:0007618	denotes	mated
T21599	36716-36724	GO_EXT:breeding	denotes	breeding
T21600	36796-36797	SO_EXT:normal_or_wild_type_or_present	denotes	+
T21601	36798-36799	SO_EXT:normal_or_wild_type_or_present	denotes	+
T21602	36909-36917	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T21603	36986-36992	GO:0007618	denotes	mating
T21604	37043-37057	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T21605	37058-37065	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T21606	37116-37127	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T22567	37248-37253	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22568	37319-37326	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T22569	37457-37460	SO_EXT:0000771	denotes	QTL
T22570	37538-37545	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	Markers
T22571	37621-37626	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22572	37694-37697	SO_EXT:0000771	denotes	QTL
T22573	37743-37746	SO_EXT:0000771	denotes	QTL
T22574	37786-37791	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22575	37815-37822	SO_EXT:0001023	denotes	alleles
T22576	37842-37845	SO_EXT:0000771	denotes	QTL
T22577	37853-37858	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22578	37882-37889	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T22579	37918-37923	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22580	37952-37955	SO_EXT:0000771	denotes	QTL
T22581	37988-37996	GO_EXT:breeding	denotes	breeding
T22582	38004-38009	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22583	38046-38053	PATO_UBERON_EXT:female_or_bearer_of_femaleness	denotes	females
T22584	38067-38072	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	males
T22585	38244-38248	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T22586	38291-38298	SO_EXT:0001023	denotes	alleles
T22587	38331-38337	SO_EXT:0001026	denotes	genome
T22588	38366-38372	SO_EXT:0001026	denotes	genome
T22589	38378-38385	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T22590	38396-38403	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T22591	38417-38424	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T22592	38482-38485	SO_EXT:0000771	denotes	QTL
T22593	38596-38600	NCBITaxon:10088	denotes	mice
T22594	38710-38716	GO:0007618	denotes	mating
T22595	38767-38781	SO_EXT:microsatellite_unit_or_region	denotes	microsatellite
T22596	38782-38789	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T22597	38840-38851	GO_SO_EXT:sequence_rearrangement_process	denotes	recombinant
T23408	38968-38976	SO_EXT:sequence_deletion_entity_or_process	denotes	deletion
T23409	39040-39047	SO_EXT:0000704	denotes	genetic
T23410	39118-39125	SO_EXT:0001023	denotes	alleles
T23411	39186-39193	SO_EXT:0001023	denotes	alleles
T23412	39560-39564	NCBITaxon:10088	denotes	mice
T23413	39591-39595	NCBITaxon:10088	denotes	Mice
T23414	39650-39657	SO_EXT:0001023	denotes	alleles
T23415	39661-39668	CHEBI_SO_EXT:molecular_indicator_or_label_or_marker_or_tag	denotes	markers
T23416	39693-39698	GO:0007618	denotes	mated
T23417	39812-39818	GO:0007618	denotes	mating
T23418	39912-39921	SO_EXT:sequence_alteration_entity_or_process	denotes	mutations
T23419	40008-40015	SO_EXT:0001023	denotes	alleles
T24373	40338-40342	NCBITaxon:10088	denotes	mice
T24374	40543-40547	NCBITaxon_UBERON_EXT:pup	denotes	pups
T24375	40556-40560	NCBITaxon:10088	denotes	Mice
T24376	40592-40596	CHEBI_EXT:33290	denotes	Feed
T24377	40617-40624	CHEBI_PR_EXT:protein	denotes	protein
T24378	40631-40634	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24379	40652-40657	CHEBI:15377	denotes	water
T24380	40683-40687	NCBITaxon:10088	denotes	Mice
T24381	40775-40779	NCBITaxon:10088	denotes	mice
T24382	40785-40797	CHEBI_EXT:anaesthetic_process	denotes	anesthetized
T24383	40804-40814	CHEBI:6015	denotes	isoflurane
T24384	40819-40824	UBERON:0000004	denotes	nasal
T24385	40825-40829	UBERON:0001245	denotes	anal
T24386	40846-40851	UBERON:0000004	denotes	nasal
T24387	40852-40856	UBERON:0002415	denotes	tail
T24388	40895-40899	UBERON:0002415	denotes	Tail
T24389	40938-40950	CHEBI_EXT:anaesthetic_process	denotes	Anesthetized
T24390	40951-40955	NCBITaxon:10088	denotes	mice
T24391	40966-40976	GO_EXT:killing	denotes	sacrificed
T24392	41012-41027	UBERON:0012283	denotes	Femoral fat pad
T24393	41020-41023	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24394	41029-41032	UBERON:0012283	denotes	FFP
T24395	41035-41050	UBERON:0003428	denotes	gonadal fat pad
T24396	41043-41046	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24397	41052-41055	UBERON:0003428	denotes	GFP
T24398	41058-41076	UBERON:0015143	denotes	mesenteric fat pad
T24399	41069-41072	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24400	41078-41081	UBERON:0015143	denotes	MFP
T24401	41087-41110	UBERON:0010411	denotes	retroperitoneal fat pad
T24402	41103-41106	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24403	41112-41115	UBERON:0010411	denotes	RFP
T24404	41161-41169	CHEBI_EXT:chemical_substance_or_polyatomic_entity	denotes	Chemical
T24405	41230-41239	UBERON:0008979	denotes	carcasses
T24406	41325-41328	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24407	41325-41332	UBERON:0003916	denotes	fat pad
T24408	41353-41360	UBERON:0008979	denotes	carcass
T24409	41373-41389	_FRAGMENT	denotes	gastrointestinal
T24410	41395-41400	UBERON:0001555	denotes	tract
T24411	41391-41393	UBERON:0005409	denotes	GI
T24412	41430-41439	UBERON:0008979	denotes	carcasses
T24413	41487-41494	UBERON:0008979	denotes	carcass
T24414	41509-41518	UBERON:0008979	denotes	Carcasses
T24415	41632-41641	UBERON:0008979	denotes	carcasses
T24416	41679-41684	CHEBI:15377	denotes	water
T24417	41757-41760	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T24418	41785-41790	CHEBI:25698	denotes	ether
T24419	41815-41822	CHEBI:15347	denotes	acetone
T24420	41872-41879	UBERON:0008979	denotes	Carcass
T24421	41966-41973	UBERON:0008979	denotes	Carcass
T24422	41974-41981	CHEBI_PR_EXT:protein	denotes	protein
T24423	41983-41987	CHEBI_PR_EXT:protein	denotes	PROT
T24424	42035-42042	UBERON:0008979	denotes	carcass
T24425	42043-42046	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	fat
T24426	42048-42051	CHEBI_UBERON_EXT:triglyceride_or_adipose_tissue	denotes	FAT
T25101	42427-42435	GO_EXT:breeding	denotes	breeding
T25102	42527-42535	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T25103	42537-42538	SO_EXT:normal_or_wild_type_or_present	denotes	+
T25104	42539-42540	SO_EXT:normal_or_wild_type_or_present	denotes	+
T25105	42631-42639	SO_EXT:genotype_or_entity_with_genotype	denotes	genotype
T25430	42925-42930	SO_EXT:0000704	denotes	genes
T25431	42931-42936	SO_EXT:0000704	denotes	Genes
T25432	43049-43056	SO_EXT:0001026	denotes	genomic
T25433	43093-43097	SO_EXT:0000704	denotes	gene
T25434	43118-43120	CHEBI_GO_PR_EXT:growth_hormone	denotes	Gh
T25435	43118-43130	GO:0060396	denotes	Gh signaling
T25436	43131-43135	SO_EXT:0000704	denotes	Gene
T25437	43240-43245	SO_EXT:0000704	denotes	genes
T25438	43293-43298	SO_EXT:0000704	denotes	genes
T25439	43314-43317	SO_EXT:0000771	denotes	QTL
T26305	43360-43364	SO_EXT:0000704	denotes	gene
T26306	43403-43418	SO_EXT:coding_sequence	denotes	coding sequence
T26307	43431-43433	_FRAGMENT	denotes	5'
T26308	43441-43461	SO_EXT:0000204	denotes	untranslated regions
T26309	43438-43461	SO_EXT:0000205	denotes	3' untranslated regions
T26310	43443-43453	GO:0006412	denotes	translated
T26311	43490-43494	SO_EXT:0000704	denotes	gene
T26312	43621-43624	CHEBI_SO_EXT:RNA	denotes	RNA
T26313	43630-43635	UBERON:0000955	denotes	brain
T26314	43637-43642	UBERON:0002107	denotes	liver
T26315	43644-43650	UBERON:0002106	denotes	spleen
T26316	43652-43656	UBERON:0002048	denotes	lung
T26317	43661-43667	UBERON:0000473	denotes	testis
T26318	43689-43694	UBERON:0007023	denotes	adult
T26319	43700-43704	PATO_UBERON_EXT:male_or_bearer_of_maleness	denotes	male
T26320	43705-43710	NCBITaxon:10088	denotes	mouse
T26321	43734-43738	SO_EXT:cDNA	denotes	cDNA
T26322	43763-43766	CHEBI_SO_EXT:RNA	denotes	RNA
T26323	43798-43804	SO_EXT:0000112	denotes	primer
T26324	43819-43823	SO_EXT:0000704	denotes	gene
T26325	43962-43970	CHEBI_EXT:platinum	denotes	Platinum
T26326	44045-44051	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T26327	44065-44073	CHEBI:75958	denotes	solution
T26328	44082-44087	CHEBI:32599	denotes	MgSO4
T26329	44097-44102	CHEBI_EXT:dNTP	denotes	dNTPs
T26330	44114-44120	SO_EXT:0000112	denotes	primer
T26331	44134-44142	CHEBI_EXT:platinum	denotes	Platinum
T26332	44143-44146	NCBITaxon:271	denotes	Taq
T26333	44187-44191	SO_EXT:cDNA	denotes	cDNA
T26334	44411-44418	CHEBI:2511	denotes	agarose
T26335	44446-44450	CHEBI:4883	denotes	EtBr
T26336	44526-44529	CHEBI:15377	denotes	H2O
T26337	44558-44561	CHEBI_SO_EXT:DNA	denotes	DNA
T26338	44609-44615	CHEBI_CHMO_EXT:buffer_solution	denotes	buffer
T26339	44624-44629	CHEBI:6636	denotes	MgCl2
T26340	44639-44644	CHEBI_EXT:dNTP	denotes	dNTPs
T26341	44656-44662	SO_EXT:0000112	denotes	primer
T26342	44676-44679	NCBITaxon:271	denotes	Taq
T26343	44847-44854	CHEBI:2511	denotes	agarose
T26344	44882-44886	CHEBI:4883	denotes	EtBr
T26345	45024-45031	CHEBI:2511	denotes	agarose
T26346	45058-45062	CHEBI:4883	denotes	EtBr
T26347	45077-45080	CHEBI_SO_EXT:DNA	denotes	DNA
T26348	45141-45152	SO_EXT:0000006	denotes	PCR product
T26349	45174-45180	SO_EXT:0000112	denotes	primer
T26921	45370-45378	SO_EXT:biological_sequence	denotes	Sequence
T26922	45391-45395	CHEBI_SO_EXT:mRNA	denotes	mRNA
T26923	45396-45405	SO_EXT:biological_sequence	denotes	sequences
T26924	45415-45419	SO_EXT:0000704	denotes	gene
T26925	45481-45487	SO_EXT:0001026	denotes	genome
T26926	45488-45496	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T26927	45509-45518	SO_EXT:biological_sequence	denotes	sequences
T26928	45553-45561	SO_EXT:biological_sequence	denotes	sequence
T26929	45585-45593	SO_EXT:biological_sequence	denotes	sequence
T26930	45594-45602	SO_EXT:sequence_assembly_entity_or_process	denotes	assembly
T26931	45668-45673	SO_EXT:0000150	denotes	reads
T26932	45703-45710	SO_EXT:0000149	denotes	contigs
T26933	45733-45737	SO_EXT:0000704	denotes	gene
T26934	45742-45755	SO_EXT:polymorphism	denotes	polymorphisms
R1375	T6885	T6884	_lexicallyChainedTo	fat pads,femoral
R1376	T6888	T6887	_lexicallyChainedTo	fat pads,mesenteric
R1377	T6891	T6890	_lexicallyChainedTo	fat pads,retroperitoneal
R3983	T13237	T13236	_lexicallyChainedTo	untranslated region,5'
R3984	T13238	T13236	_lexicallyChainedTo	UTR,5'
R3985	T13241	T13240	_lexicallyChainedTo	UTR,3'
R3986	T13256	T13255	_lexicallyChainedTo	UTRs,5'
R4336	T17608	T17607	_lexicallyChainedTo	signaling pathway,Gh
R7462	T24410	T24409	_lexicallyChainedTo	tract,gastrointestinal
R8042	T26308	T26307	_lexicallyChainedTo	untranslated regions,5'
R1374	T6882	T6881	_lexicallyChainedTo	fat pads,gonadal

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id	Subject	Object	Predicate	Lexical cue
T528	0-6	SO:0001026	denotes	Genome
T529	44-47	SO:0000771	denotes	QTL
T530	54-59	NCBITaxon:10088	denotes	mouse
T531	157-180	SO:0000771	denotes	quantitative trait loci
T532	182-185	SO:0000771	denotes	QTL
T533	219-226	UBERON:0008979	denotes	carcass
T534	269-274	NCBITaxon:10088	denotes	mouse
T535	288-291	NCBITaxon:10090	denotes	MMU
T536	360-363	SO:0000771	denotes	QTL
T537	450-453	SO:0000771	denotes	QTL
T538	454-461	SO:0001023	denotes	alleles
T539	528-535	SO:0000704	denotes	genetic
T540	847-850	SO:0000771	denotes	QTL
T541	1025-1028	SO:0000771	denotes	QTL
T542	1290-1293	SO:0000771	denotes	QTL
T543	1474-1481	SO:0001026	denotes	genomic
T544	1553-1560	SO:0000704	denotes	genetic
T2553	1626-1631	NCBITaxon:10088	denotes	mouse
T2554	1694-1699	SO:0000704	denotes	genic
T2555	1727-1731	SO:0000704	denotes	gene
T2556	1781-1788	SO:0000704	denotes	genetic
T2557	1839-1844	NCBITaxon:9606	denotes	human
T2558	1885-1890	SO:0000704	denotes	genic
T2559	1968-1991	SO:0000771	denotes	quantitative trait loci
T2560	1993-1996	SO:0000771	denotes	QTL
T2561	2017-2020	SO:0000771	denotes	QTL
T2562	2021-2028	SO:0001023	denotes	alleles
T2563	2062-2065	SO:0000771	denotes	QTL
T2564	2109-2114	NCBITaxon:10088	denotes	mouse
T2565	2134-2137	SO:0000771	denotes	QTL
T2566	2257-2264	SO:0000704	denotes	genetic
T2567	2305-2308	SO:0000771	denotes	QTL
T2568	2374-2379	SO:0000704	denotes	genic
T2569	2417-2422	SO:0000704	denotes	genic
T2570	2472-2479	SO:0000704	denotes	genetic
T2571	2616-2627	SO:0000704	denotes	genetically
T2572	2638-2642	NCBITaxon:10088	denotes	mice
T2573	2764-2767	SO:0000771	denotes	QTL
T2574	2836-2839	SO:0000771	denotes	QTL
T2575	2840-2847	SO:0001023	denotes	alleles
T2576	2901-2916	SO:0001645	denotes	genetic markers
T2577	2925-2932	SO:0000704	denotes	genetic
T2578	3317-3321	NCBITaxon:10088	denotes	mice
T2579	3345-3352	SO:0001023	denotes	alleles
T2580	3495-3500	NCBITaxon:10088	denotes	mouse
T2581	3501-3504	SO:0000771	denotes	QTL
T2582	3594-3599	NCBITaxon:10088	denotes	mouse
T2583	3699-3709	GO:0010467	denotes	expression
T2584	3717-3722	PR:000015393	denotes	Socs2
T2585	3724-3758	PR:000015393	denotes	suppressor of cytokine signaling 2
T2586	3738-3756	GO:0019221	denotes	cytokine signaling
T2587	3760-3764	SO:0000704	denotes	gene
T2588	3786-3791	PR:000015393	denotes	Socs2
T2589	3857-3862	PR:000015393	denotes	Socs2
T2590	3875-3880	NCBITaxon:10088	denotes	mouse
T2591	3962-3965	SO:0000771	denotes	QTL
T2592	4046-4049	SO:0000771	denotes	QTL
T2593	4065-4068	SO:0000771	denotes	QTL
T2594	4167-4171	SO:0000704	denotes	gene
T2595	4356-4360	SO:0000704	denotes	gene
T2596	4418-4427	GO:0008152	denotes	metabolic
T2597	4447-4454	SO:0000704	denotes	genetic
T2598	4567-4572	PR:000015393	denotes	Socs2
T2599	4742-4762	GO:0060396	denotes	Gh signaling pathway
T2600	4847-4860	GO:0008152	denotes	metabolically
T2601	4964-4971	UBERON:0008979	denotes	carcass
T2602	4984-4987	SO:0000771	denotes	QTL
T2603	5063-5067	NCBITaxon:10088	denotes	mice
T2604	5156-5159	SO:0000771	denotes	QTL
T2605	5203-5207	NCBITaxon:10088	denotes	mice
T2606	5254-5258	SO:0000704	denotes	gene
T2607	5308-5311	SO:0000771	denotes	QTL
T2608	5420-5423	SO:0000771	denotes	QTL
T2609	5650-5660	GO:0010467	denotes	expression
T2610	5790-5793	SO:0000771	denotes	QTL
T2611	6088-6091	SO:0000771	denotes	QTL
T2612	6105-6108	SO:0000771	denotes	QTL
T2613	6176-6179	SO:0000771	denotes	QTL
T2614	6197-6202	SO:0000704	denotes	genes
T2615	6215-6227	GO:0060396	denotes	Gh signaling
T2616	6235-6242	SO:0001026	denotes	genomic
T2617	6275-6278	SO:0000771	denotes	QTL
T4054	6469-6472	SO:0000771	denotes	QTL
T4055	6641-6648	SO:0000704	denotes	genetic
T4056	6758-6761	SO:0000771	denotes	QTL
T4057	6874-6880	SO:0001026	denotes	genome
T4058	7012-7019	SO:0001026	denotes	genomic
T4059	7191-7197	SO:0001026	denotes	genome
T4060	7475-7487	GO:0000003	denotes	reproductive
T4061	7583-7591	SO:0000357	denotes	flanking
T6774	7810-7813	SO:0000771	denotes	QTL
T6775	7928-7935	SO:0000704	denotes	genetic
T6776	8371-8375	NCBITaxon:10088	denotes	mice
T6777	8646-8649	SO:0000771	denotes	QTL
T6778	8850-8854	NCBITaxon:10088	denotes	mice
T6779	8887-8891	UBERON:0002415	denotes	tail
T6780	8925-8929	UBERON:0000004	denotes	naso
T6781	8930-8934	UBERON:0001245	denotes	anal
T6782	8976-8980	NCBITaxon:10088	denotes	mice
T6783	9163-9167	UBERON:0002415	denotes	tail
T6784	9235-9239	NCBITaxon:10088	denotes	mice
T6785	9335-9339	NCBITaxon:10088	denotes	mice
T6786	9421-9424	SO:0000771	denotes	QTL
T6787	9548-9552	UBERON:0002415	denotes	tail
T6788	9583-9586	SO:0000771	denotes	QTL
T6789	9685-9688	SO:0000771	denotes	QTL
T6790	10027-10030	SO:0000771	denotes	QTL
T6791	10060-10066	SO:0001026	denotes	genome
T6792	10213-10216	SO:0000771	denotes	QTL
T6793	10336-10343	UBERON:0003916	denotes	fat pad
T6794	10423-10430	_FRAGMENT	denotes	gonadal
T6795	10496-10504	UBERON:0003428	denotes	fat pads
T6796	10432-10435	UBERON:0003428	denotes	GFP
T6797	10438-10445	_FRAGMENT	denotes	femoral
T6798	10496-10504	UBERON:0012283	denotes	fat pads
T6799	10447-10450	UBERON:0012283	denotes	FFP
T6800	10453-10463	_FRAGMENT	denotes	mesenteric
T6801	10496-10504	UBERON:0015143	denotes	fat pads
T6802	10465-10468	UBERON:0015143	denotes	MFP
T6803	10474-10489	_FRAGMENT	denotes	retroperitoneal
T6804	10496-10504	UBERON:0010411	denotes	fat pads
T6805	10491-10494	UBERON:0010411	denotes	RFP
T6806	10523-10530	UBERON:0003916	denotes	fat pad
T6807	10555-10563	UBERON:0003916	denotes	fat pads
T6808	10951-10955	NCBITaxon:10088	denotes	mice
T6809	11007-11010	SO:0000771	denotes	QTL
T6810	11094-11101	UBERON:0003916	denotes	fat pad
T6811	11216-11220	NCBITaxon:10088	denotes	mice
T6812	11430-11434	NCBITaxon:10088	denotes	mice
T6813	11469-11472	SO:0000771	denotes	QTL
T6814	11598-11601	SO:0000771	denotes	QTL
T6815	11645-11649	UBERON:0002415	denotes	tail
T6816	11705-11708	UBERON:0003428	denotes	GFP
T6817	11710-11713	UBERON:0015143	denotes	MFP
T6818	11715-11718	UBERON:0010411	denotes	RFP
T6819	11758-11762	NCBITaxon:10088	denotes	mice
T6820	11862-11865	SO:0000771	denotes	QTL
T6821	11919-11923	NCBITaxon:10088	denotes	mice
T6822	12167-12170	SO:0000771	denotes	QTL
T6823	12272-12275	SO:0000771	denotes	QTL
T6824	12389-12392	SO:0000771	denotes	QTL
T6825	12504-12511	SO:0000704	denotes	genetic
T6826	12660-12663	SO:0000771	denotes	QTL
T6827	12690-12697	SO:0001026	denotes	genomic
T6828	12751-12755	SO:0000704	denotes	gene
T6829	12888-12892	NCBITaxon:10088	denotes	mice
T6830	13095-13098	SO:0000771	denotes	QTL
T6831	13123-13125	SO:0000028	denotes	bp
T6832	13378-13382	NCBITaxon:10088	denotes	mice
T6833	13455-13459	NCBITaxon:10088	denotes	mice
T6834	14267-14270	SO:0000771	denotes	QTL
T10880	14338-14341	SO:0000771	denotes	QTL
T10881	14426-14429	SO:0000771	denotes	QTL
T10882	14568-14572	NCBITaxon:10088	denotes	mice
T10883	14667-14671	UBERON:0002415	denotes	tail
T10884	14809-14812	UBERON:0015143	denotes	MFP
T10885	14895-14898	SO:0000771	denotes	QTL
T10886	14924-14927	SO:0000771	denotes	QTL
T10887	14991-14997	SO:0001026	denotes	genome
T10888	15085-15088	SO:0000771	denotes	QTL
T10889	15175-15179	NCBITaxon:10088	denotes	mice
T10890	15316-15323	UBERON:0003916	denotes	fat pad
T10891	15368-15371	UBERON:0015143	denotes	MFP
T10892	15564-15567	UBERON:0003428	denotes	GFP
T10893	15569-15572	UBERON:0015143	denotes	MFP
T10894	15595-15598	UBERON:0010411	denotes	RFP
T10895	15692-15696	NCBITaxon:10088	denotes	mice
T10896	15743-15750	SO:0001023	denotes	alleles
T10897	15795-15802	SO:0001023	denotes	alleles
T10898	15927-15932	UBERON:0000981	denotes	femur
T10899	15998-16001	SO:0000771	denotes	QTL
T10900	16189-16194	UBERON:0000981	denotes	femur
T10901	16277-16281	NCBITaxon:10088	denotes	mice
T10902	16317-16321	NCBITaxon:10088	denotes	mice
T10903	16330-16333	UBERON:0015143	denotes	MFP
T10904	16386-16389	UBERON:0003428	denotes	GFP
T10905	16391-16394	UBERON:0010411	denotes	RFP
T10906	16396-16399	UBERON:0012283	denotes	FFP
T10907	16773-16778	UBERON:0000981	denotes	femur
T10908	16804-16808	NCBITaxon:10088	denotes	mice
T10909	16864-16867	SO:0000771	denotes	QTL
T10910	17079-17086	SO:0001023	denotes	alleles
T10911	17144-17151	UBERON:0008979	denotes	carcass
T10912	17166-17173	UBERON:0008979	denotes	carcass
T10913	17223-17230	UBERON:0008979	denotes	carcass
T10914	17454-17458	NCBITaxon:10088	denotes	mice
T10915	17832-17836	UBERON:0002415	denotes	tail
T10916	17978-17981	SO:0000771	denotes	QTL
T10917	18325-18330	CHEBI:18059	denotes	lipid
T10918	18355-18362	UBERON:0003916	denotes	fat pad
T10919	18404-18411	UBERON:0008979	denotes	carcass
T10920	18448-18455	UBERON:0008979	denotes	carcass
T10921	18479-18489	UBERON:0000468	denotes	total body
T10922	18501-18507	UBERON:0000062	denotes	organs
T10923	18519-18523	UBERON:0000033	denotes	head
T10924	18528-18550	UBERON:0001555	denotes	gastrointestinal tract
T10925	18698-18705	UBERON:0003916	denotes	fat pad
T10926	18753-18763	UBERON:0000468	denotes	whole body
T10927	18920-18928	UBERON:0003916	denotes	fat pads
T10928	18937-18940	UBERON:0015143	denotes	MFP
T10929	19207-19214	UBERON:0003916	denotes	fat pad
T10930	19236-19245	UBERON:0008979	denotes	carcasses
T10931	19297-19306	UBERON:0008979	denotes	carcasses
T10932	19325-19332	UBERON:0008979	denotes	carcass
T10933	19381-19390	UBERON:0008979	denotes	carcasses
T10934	19417-19420	CHEBI:15377	denotes	H2O
T10935	19500-19503	CHEBI:15377	denotes	H2O
T10936	19506-19509	CHEBI:15377	denotes	H2O
T10937	19697-19703	UBERON:0000479	denotes	tissue
T10938	19719-19724	CHEBI:18059	denotes	lipid
T10939	19846-19849	SO:0000771	denotes	QTL
T10940	19910-19917	SO:0001023	denotes	alleles
T10941	19969-19974	UBERON:0000981	denotes	femur
T10942	20039-20043	NCBITaxon:10088	denotes	mice
T10943	20281-20285	NCBITaxon:10088	denotes	mice
T10944	20362-20366	NCBITaxon:10088	denotes	mice
T10945	20472-20476	UBERON:0002415	denotes	tail
T10946	20551-20555	NCBITaxon:10088	denotes	mice
T10947	20583-20591	UBERON:0003916	denotes	fat pads
T10948	20600-20603	UBERON:0015143	denotes	MFP
T10949	20725-20734	UBERON:0008979	denotes	carcasses
T10950	20761-20764	CHEBI:15377	denotes	H2O
T10951	20787-20796	UBERON:0008979	denotes	carcasses
T10952	20825-20828	CHEBI:15377	denotes	H2O
T13183	20903-20907	SO:0000704	denotes	gene
T13184	20962-20967	PR:000015393	denotes	Socs2
T13185	20996-20999	SO:0000771	denotes	QTL
T13186	21078-21083	SO:0000704	denotes	genes
T13187	21153-21158	SO:0000704	denotes	genes
T13188	21188-21193	SO:0000704	denotes	genes
T13189	21233-21245	GO:0060396	denotes	Gh signaling
T13190	21344-21349	SO:0000704	denotes	genes
T13191	21452-21456	SO:0000704	denotes	Gene
T13192	21550-21554	SO:0000704	denotes	gene
T13193	21707-21709	SO:0000028	denotes	bp
T13194	21733-21735	SO:0000028	denotes	bp
T13195	21752-21754	SO:0000028	denotes	bp
T13196	21755-21757	_FRAGMENT	denotes	5'
T13197	21765-21784	SO:0000204	denotes	untranslated region
T13198	21786-21789	SO:0000204	denotes	UTR
T13199	21762-21784	SO:0000205	denotes	3' untranslated region
T13200	21762-21764	_FRAGMENT	denotes	3'
T13201	21786-21789	SO:0000205	denotes	UTR
T13202	21767-21777	GO:0006412	denotes	translated
T13203	21928-21934	SO:0001026	denotes	genome
T13204	22077-22108	SO:0000694	denotes	single nucleotide polymorphisms
T13205	22110-22113	SO:0000694	denotes	SNP
T13206	22231-22233	_FRAGMENT	denotes	5'
T13207	22241-22245	SO:0000204	denotes	UTRs
T13208	22238-22245	SO:0000205	denotes	3' UTRs
T13209	22257-22270	SO:0001816	denotes	nonsynonomous
T13210	22271-22274	SO:0000694	denotes	SNP
T13211	22315-22320	SO:0000704	denotes	genes
T13212	22589-22599	SO:0000857	denotes	homologous
T13213	22724-22729	SO:0000704	denotes	genes
T17326	22876-22879	SO:0000771	denotes	QTL
T17327	22979-22985	SO:0001026	denotes	genome
T17328	23031-23038	UBERON:0008979	denotes	carcass
T17329	23051-23054	SO:0000771	denotes	QTL
T17330	23256-23259	SO:0000771	denotes	QTL
T17331	23324-23327	SO:0000771	denotes	QTL
T17332	23437-23441	NCBITaxon:10088	denotes	mice
T17333	23503-23510	SO:0000704	denotes	genetic
T17334	23551-23575	SO:0000771	denotes	quantitative trait genes
T17335	23643-23646	SO:0000771	denotes	QTL
T17336	23678-23685	SO:0001023	denotes	alleles
T17337	23841-23848	SO:0001023	denotes	alleles
T17338	23971-23975	NCBITaxon:10088	denotes	mice
T17339	24081-24084	SO:0000771	denotes	QTL
T17340	24255-24258	SO:0000771	denotes	QTL
T17341	24353-24356	SO:0000771	denotes	QTL
T17342	24455-24462	SO:0001023	denotes	alleles
T17343	24480-24483	SO:0000771	denotes	QTL
T17344	24508-24511	SO:0000771	denotes	QTL
T17345	24598-24601	SO:0000771	denotes	QTL
T17346	24630-24637	CHEBI:16236	denotes	ethanol
T17347	24672-24680	SO:0000357	denotes	flanking
T17348	24681-24684	SO:0000771	denotes	QTL
T17349	24701-24707	SO:0001026	denotes	genome
T17350	24770-24773	SO:0000771	denotes	QTL
T17351	24796-24802	SO:0001026	denotes	genome
T17352	24883-24890	SO:0000704	denotes	genetic
T17353	25000-25007	SO:0000704	denotes	genetic
T17354	25260-25265	NCBITaxon:10088	denotes	mouse
T17355	25399-25406	SO:0001026	denotes	genomic
T17356	25579-25586	SO:0001023	denotes	alleles
T17357	25706-25709	SO:0000771	denotes	QTL
T17358	25719-25722	SO:0000771	denotes	QTL
T17359	25816-25819	SO:0000771	denotes	QTL
T17360	25980-25985	SO:0000704	denotes	genes
T17361	26184-26187	SO:0000771	denotes	QTL
T17362	26362-26365	SO:0000771	denotes	QTL
T17363	26449-26452	SO:0000771	denotes	QTL
T17364	26472-26482	GO:0010467	denotes	expression
T17365	26492-26495	SO:0000771	denotes	QTL
T17366	26665-26668	SO:0000771	denotes	QTL
T17367	26809-26814	CHEBI:18059	denotes	lipid
T17368	26809-26822	GO:0019915	denotes	lipid storage
T17369	26860-26864	NCBITaxon:10088	denotes	mice
T17370	26941-26945	NCBITaxon:10088	denotes	mice
T17371	26981-26984	SO:0000771	denotes	QTL
T17372	27123-27126	SO:0000771	denotes	QTL
T17373	27303-27306	SO:0000771	denotes	QTL
T17374	27337-27340	SO:0000771	denotes	QTL
T17375	27399-27403	NCBITaxon:10088	denotes	mice
T17376	27416-27419	SO:0000771	denotes	QTL
T17377	27489-27493	SO:0000704	denotes	gene
T17378	27495-27498	SO:0000771	denotes	QTL
T17379	27525-27530	PR:000015393	denotes	Socs2
T17380	27605-27608	SO:0000771	denotes	QTL
T17381	27643-27648	SO:0000704	denotes	genes
T17382	27708-27716	GO:0065007	denotes	modulate
T17383	27770-27773	SO:0000771	denotes	QTL
T17384	27846-27849	SO:0000771	denotes	QTL
T17385	27916-27936	GO:0040008	denotes	regulation of growth
T17386	27980-27985	NCBITaxon:9606	denotes	human
T17387	28007-28011	NCBITaxon:10088	denotes	mice
T17388	28185-28188	SO:0000771	denotes	QTL
T17389	28217-28220	SO:0000771	denotes	QTL
T17390	28290-28294	NCBITaxon:10088	denotes	mice
T17391	28323-28328	SO:0000704	denotes	genes
T17392	28369-28419	PR:000002087	denotes	signal transducer and activator of transcription 1
T17393	28421-28426	PR:000002087	denotes	Stat1
T17394	28432-28437	PR:000002090	denotes	Stat4
T17395	28503-28517	UBERON:0001013	denotes	adipose tissue
T17396	28670-28675	NCBITaxon:10088	denotes	mouse
T17397	28857-28867	GO:0010467	denotes	expression
T17398	28925-28930	NCBITaxon:10088	denotes	mouse
T17399	29010-29020	GO:0065007	denotes	modulation
T17400	29024-29038	UBERON:0001013	denotes	adipose tissue
T17401	29276-29280	CHEBI:33290	denotes	food
T17402	29276-29287	GO:0007631	denotes	food intake
T17403	29292-29299	PR:000045358	denotes	insulin
T17404	29401-29405	NCBITaxon:10088	denotes	mice
T17405	29518-29525	GO:0040007	denotes	growing
T17406	29675-29681	SO:0001026	denotes	genome
T17407	29811-29816	SO:0000704	denotes	genes
T17408	29841-29843	_FRAGMENT	denotes	Gh
T17409	29858-29875	GO:0060396	denotes	signaling pathway
T17410	29844-29857	GO:0005622	denotes	intracellular
T17411	29844-29875	GO:0030522	denotes	intracellular signaling pathway
T17412	29889-29895	PR:000002092	denotes	Stat5b
T17413	29900-29906	PR:000002091	denotes	Stat5a
T17414	29930-29933	SO:0000771	denotes	QTL
T17415	30011-30016	NCBITaxon:10088	denotes	mouse
T17416	30117-30121	SO:0000704	denotes	gene
T17417	30117-30132	GO:0010467	denotes	gene expression
T17418	30223-30227	SO:0000704	denotes	gene
T17419	30289-30293	SO:0000704	denotes	gene
T17420	30305-30311	PR:000002092	denotes	Stat5b
T17421	30437-30442	PR:000015393	denotes	Socs2
T17422	30476-30486	GO:0065007	denotes	regulation
T17423	30532-30538	PR:000002092	denotes	Stat5b
T17424	30587-30591	NCBITaxon:10088	denotes	mice
T17425	30677-30682	UBERON:0002107	denotes	liver
T17426	30683-30687	SO:0000704	denotes	gene
T17427	30683-30698	GO:0010467	denotes	gene expression
T17428	30816-30822	PR:000002092	denotes	Stat5b
T17429	30836-30846	GO:0010467	denotes	expression
T17430	30868-30872	NCBITaxon:10088	denotes	mice
T17431	30890-30893	SO:0000771	denotes	QTL
T17432	30970-30977	UBERON:0008979	denotes	carcass
T17433	31020-31024	SO:0000704	denotes	gene
T17434	31052-31057	PR:000001672	denotes	Sstr5
T17435	31084-31093	CHEBI:35222	denotes	inhibitor
T17436	31104-31109	PR:000001672	denotes	Sstr5
T17437	31187-31197	UBERON:0001264	denotes	pancreatic
T17438	31187-31207	CL:0000169	denotes	pancreatic beta cell
T17439	31229-31234	PR:000001672	denotes	Sstr5
T17440	31259-31266	PR:000045358	denotes	insulin
T17441	31281-31288	CHEBI:17234	denotes	glucose
T17442	31281-31300	GO:0042593	denotes	glucose homeostasis
T17443	31345-31350	SO:0000704	denotes	genes
T17444	31580-31583	SO:0000694	denotes	SNP
T17445	31711-31715	SO:0000704	denotes	gene
T17446	31711-31726	GO:0010467	denotes	gene expression
T17447	31746-31749	SO:0000694	denotes	SNP
T17448	31773-31776	SO:0000694	denotes	SNP
T17449	31788-31790	SO:0000028	denotes	bp
T17450	31800-31805	SO:0000704	denotes	genes
T17451	32022-32026	SO:0000704	denotes	gene
T17452	32022-32037	GO:0010467	denotes	gene expression
T17453	32069-32079	GO:0010467	denotes	expression
T17454	32113-32118	SO:0000704	denotes	genes
T17455	32257-32270	SO:0001816	denotes	nonsynonomous
T17456	32304-32307	SO:0000771	denotes	QTL
T17457	32431-32436	SO:0000704	denotes	genes
T17458	32613-32618	SO:0000704	denotes	genes
T17459	32620-32624	PR:000017012	denotes	Ubr1
T17460	32626-32632	PR:000001968	denotes	Ptpns1
T17461	32634-32642	PR:000017005	denotes	Ubce7ip5
T17462	32647-32651	PR:000010491	denotes	Mmp9
T17463	32733-32738	PR:000015393	denotes	Socs2
T17464	32751-32799	GO:0043161	denotes	ubiquitination dependent proteasomal degradation
T17465	32776-32787	GO:0000502	denotes	proteasomal
T17466	32811-32823	GO:0060396	denotes	Gh signaling
T17467	32830-32834	PR:000017012	denotes	Ubr1
T17468	32839-32847	PR:000017005	denotes	Ubce7ip5
T17469	32869-32891	GO:0016567	denotes	protein ubiquitination
T17470	32896-32900	PR:000017012	denotes	Ubr1
T17471	32910-32914	NCBITaxon:10088	denotes	mice
T17472	32980-32994	UBERON:0001013	denotes	adipose tissue
T17473	33004-33010	PR:000001968	denotes	Ptpns1
T17474	33020-33024	NCBITaxon:10088	denotes	mice
T17475	33075-33079	PR:000010491	denotes	Mmp9
T17476	33089-33093	NCBITaxon:10088	denotes	mice
T17477	33174-33179	SO:0000704	denotes	genes
T17478	33242-33247	SO:0000704	denotes	genes
T19880	33409-33415	SO:0001026	denotes	genome
T19881	33421-33424	SO:0000771	denotes	QTL
T19882	33455-33462	UBERON:0008979	denotes	carcass
T19883	33549-33552	SO:0000771	denotes	QTL
T19884	33684-33687	SO:0000771	denotes	QTL
T19885	33800-33807	SO:0000704	denotes	genetic
T20216	33854-33859	NCBITaxon:10088	denotes	Mouse
T20217	33907-33911	NCBITaxon:10088	denotes	mice
T20218	34127-34131	NCBITaxon:10088	denotes	mice
T20219	34210-34214	NCBITaxon:10088	denotes	Mice
T20220	34482-34488	NCBITaxon:33208	denotes	Animal
T20731	34564-34568	UBERON:0002415	denotes	tail
T20732	34653-34657	CHEBI:63016	denotes	NP40
T20733	34673-34681	CHEBI:53424	denotes	Tween 20
T20734	34780-34783	CHEBI:15377	denotes	H2O
T20735	35021-35025	NCBITaxon:10088	denotes	mice
T20736	35060-35066	SO:0000112	denotes	primer
T20737	35089-35095	SO:0000112	denotes	primer
T20738	35104-35105	SO:0001030	denotes	F
T20739	35134-35135	SO:0001031	denotes	R
T20740	35199-35201	SO:0000028	denotes	bp
T20741	35228-35232	NCBITaxon:10088	denotes	mice
T20742	35257-35258	SO:0001030	denotes	F
T20743	35292-35293	SO:0001031	denotes	R
T20744	35333-35335	SO:0000028	denotes	bp
T20745	35336-35341	PR:000005845	denotes	Cradd
T20746	35400-35404	NCBITaxon:10088	denotes	mice
T20747	35419-35428	GO:0097617	denotes	annealing
T20748	35458-35463	CHEBI:6636	denotes	MgCl2
T21561	35688-35692	NCBITaxon:10088	denotes	mice
T21562	35796-35798	SO:0000028	denotes	bp
T21563	35927-35933	SO:0001026	denotes	genome
T21564	35988-35991	SO:0000771	denotes	QTL
T21565	36082-36088	SO:0001026	denotes	genome
T21566	36141-36148	SO:0001023	denotes	alleles
T21567	36636-36640	NCBITaxon:10088	denotes	mice
T21568	36651-36656	GO:0007618	denotes	mated
T21569	36986-36992	GO:0007618	denotes	mating
T22555	37457-37460	SO:0000771	denotes	QTL
T22556	37694-37697	SO:0000771	denotes	QTL
T22557	37743-37746	SO:0000771	denotes	QTL
T22558	37815-37822	SO:0001023	denotes	alleles
T22559	37842-37845	SO:0000771	denotes	QTL
T22560	37952-37955	SO:0000771	denotes	QTL
T22561	38291-38298	SO:0001023	denotes	alleles
T22562	38331-38337	SO:0001026	denotes	genome
T22563	38366-38372	SO:0001026	denotes	genome
T22564	38482-38485	SO:0000771	denotes	QTL
T22565	38596-38600	NCBITaxon:10088	denotes	mice
T22566	38710-38716	GO:0007618	denotes	mating
T23399	39040-39047	SO:0000704	denotes	genetic
T23400	39118-39125	SO:0001023	denotes	alleles
T23401	39186-39193	SO:0001023	denotes	alleles
T23402	39560-39564	NCBITaxon:10088	denotes	mice
T23403	39591-39595	NCBITaxon:10088	denotes	Mice
T23404	39650-39657	SO:0001023	denotes	alleles
T23405	39693-39698	GO:0007618	denotes	mated
T23406	39812-39818	GO:0007618	denotes	mating
T23407	40008-40015	SO:0001023	denotes	alleles
T24336	40338-40342	NCBITaxon:10088	denotes	mice
T24337	40556-40560	NCBITaxon:10088	denotes	Mice
T24338	40592-40596	CHEBI:33290	denotes	Feed
T24339	40652-40657	CHEBI:15377	denotes	water
T24340	40683-40687	NCBITaxon:10088	denotes	Mice
T24341	40775-40779	NCBITaxon:10088	denotes	mice
T24342	40804-40814	CHEBI:6015	denotes	isoflurane
T24343	40819-40824	UBERON:0000004	denotes	nasal
T24344	40825-40829	UBERON:0001245	denotes	anal
T24345	40846-40851	UBERON:0000004	denotes	nasal
T24346	40852-40856	UBERON:0002415	denotes	tail
T24347	40895-40899	UBERON:0002415	denotes	Tail
T24348	40951-40955	NCBITaxon:10088	denotes	mice
T24349	41012-41027	UBERON:0012283	denotes	Femoral fat pad
T24350	41029-41032	UBERON:0012283	denotes	FFP
T24351	41035-41050	UBERON:0003428	denotes	gonadal fat pad
T24352	41052-41055	UBERON:0003428	denotes	GFP
T24353	41058-41076	UBERON:0015143	denotes	mesenteric fat pad
T24354	41078-41081	UBERON:0015143	denotes	MFP
T24355	41087-41110	UBERON:0010411	denotes	retroperitoneal fat pad
T24356	41112-41115	UBERON:0010411	denotes	RFP
T24357	41230-41239	UBERON:0008979	denotes	carcasses
T24358	41325-41332	UBERON:0003916	denotes	fat pad
T24359	41353-41360	UBERON:0008979	denotes	carcass
T24360	41373-41389	_FRAGMENT	denotes	gastrointestinal
T24361	41395-41400	UBERON:0001555	denotes	tract
T24362	41391-41393	UBERON:0005409	denotes	GI
T24363	41430-41439	UBERON:0008979	denotes	carcasses
T24364	41487-41494	UBERON:0008979	denotes	carcass
T24365	41509-41518	UBERON:0008979	denotes	Carcasses
T24366	41632-41641	UBERON:0008979	denotes	carcasses
T24367	41679-41684	CHEBI:15377	denotes	water
T24368	41785-41790	CHEBI:25698	denotes	ether
T24369	41815-41822	CHEBI:15347	denotes	acetone
T24370	41872-41879	UBERON:0008979	denotes	Carcass
T24371	41966-41973	UBERON:0008979	denotes	Carcass
T24372	42035-42042	UBERON:0008979	denotes	carcass
T25421	42925-42930	SO:0000704	denotes	genes
T25422	42931-42936	SO:0000704	denotes	Genes
T25423	43049-43056	SO:0001026	denotes	genomic
T25424	43093-43097	SO:0000704	denotes	gene
T25425	43118-43130	GO:0060396	denotes	Gh signaling
T25426	43131-43135	SO:0000704	denotes	Gene
T25427	43240-43245	SO:0000704	denotes	genes
T25428	43293-43298	SO:0000704	denotes	genes
T25429	43314-43317	SO:0000771	denotes	QTL
T26274	43360-43364	SO:0000704	denotes	gene
T26275	43431-43433	_FRAGMENT	denotes	5'
T26276	43441-43461	SO:0000204	denotes	untranslated regions
T26277	43438-43461	SO:0000205	denotes	3' untranslated regions
T26278	43443-43453	GO:0006412	denotes	translated
T26279	43490-43494	SO:0000704	denotes	gene
T26280	43630-43635	UBERON:0000955	denotes	brain
T26281	43637-43642	UBERON:0002107	denotes	liver
T26282	43644-43650	UBERON:0002106	denotes	spleen
T26283	43652-43656	UBERON:0002048	denotes	lung
T26284	43661-43667	UBERON:0000473	denotes	testis
T26285	43689-43694	UBERON:0007023	denotes	adult
T26286	43705-43710	NCBITaxon:10088	denotes	mouse
T26287	43798-43804	SO:0000112	denotes	primer
T26288	43819-43823	SO:0000704	denotes	gene
T26289	44065-44073	CHEBI:75958	denotes	solution
T26290	44082-44087	CHEBI:32599	denotes	MgSO4
T26291	44114-44120	SO:0000112	denotes	primer
T26292	44143-44146	NCBITaxon:271	denotes	Taq
T26293	44411-44418	CHEBI:2511	denotes	agarose
T26294	44446-44450	CHEBI:4883	denotes	EtBr
T26295	44526-44529	CHEBI:15377	denotes	H2O
T26296	44624-44629	CHEBI:6636	denotes	MgCl2
T26297	44656-44662	SO:0000112	denotes	primer
T26298	44676-44679	NCBITaxon:271	denotes	Taq
T26299	44847-44854	CHEBI:2511	denotes	agarose
T26300	44882-44886	CHEBI:4883	denotes	EtBr
T26301	45024-45031	CHEBI:2511	denotes	agarose
T26302	45058-45062	CHEBI:4883	denotes	EtBr
T26303	45141-45152	SO:0000006	denotes	PCR product
T26304	45174-45180	SO:0000112	denotes	primer
T26916	45415-45419	SO:0000704	denotes	gene
T26917	45481-45487	SO:0001026	denotes	genome
T26918	45668-45673	SO:0000150	denotes	reads
T26919	45703-45710	SO:0000149	denotes	contigs
T26920	45733-45737	SO:0000704	denotes	gene
R1371	T6798	T6797	_lexicallyChainedTo	fat pads,femoral
R1372	T6801	T6800	_lexicallyChainedTo	fat pads,mesenteric
R1373	T6804	T6803	_lexicallyChainedTo	fat pads,retroperitoneal
R3979	T13197	T13196	_lexicallyChainedTo	untranslated region,5'
R3980	T13198	T13196	_lexicallyChainedTo	UTR,5'
R3981	T13201	T13200	_lexicallyChainedTo	UTR,3'
R3982	T13207	T13206	_lexicallyChainedTo	UTRs,5'
R4335	T17409	T17408	_lexicallyChainedTo	signaling pathway,Gh
R7461	T24361	T24360	_lexicallyChainedTo	tract,gastrointestinal
R8041	T26276	T26275	_lexicallyChainedTo	untranslated regions,5'
R1370	T6795	T6794	_lexicallyChainedTo	fat pads,gonadal

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