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IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T23011","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T23010","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T23009","span":{"begin":600,"end":606},"obj":"Protein"},{"id":"T23008","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23007","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T23006","span":{"begin":437,"end":443},"obj":"Protein"},{"id":"T23005","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T23004","span":{"begin":326,"end":332},"obj":"Protein"},{"id":"T23003","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T23002","span":{"begin":212,"end":218},"obj":"Protein"},{"id":"T23001","span":{"begin":199,"end":205},"obj":"Protein"},{"id":"T23000","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T22999","span":{"begin":81,"end":87},"obj":"Protein"},{"id":"T22998","span":{"begin":57,"end":63},"obj":"Protein"},{"id":"T22997","span":{"begin":3,"end":8},"obj":"Protein"},{"id":"T23018","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T23017","span":{"begin":1084,"end":1090},"obj":"Protein"},{"id":"T23016","span":{"begin":990,"end":996},"obj":"Protein"},{"id":"T23015","span":{"begin":918,"end":924},"obj":"Protein"},{"id":"T23014","span":{"begin":868,"end":874},"obj":"Protein"},{"id":"T23013","span":{"begin":770,"end":776},"obj":"Protein"},{"id":"T23012","span":{"begin":757,"end":763},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T23361","span":{"begin":1111,"end":1117},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23360","span":{"begin":918,"end":924},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23359","span":{"begin":668,"end":674},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23358","span":{"begin":562,"end":568},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23357","span":{"begin":1084,"end":1090},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23356","span":{"begin":990,"end":996},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23355","span":{"begin":868,"end":874},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23354","span":{"begin":770,"end":776},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23353","span":{"begin":757,"end":763},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23352","span":{"begin":638,"end":644},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23351","span":{"begin":600,"end":606},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23350","span":{"begin":437,"end":443},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23349","span":{"begin":350,"end":356},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23348","span":{"begin":326,"end":332},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23347","span":{"begin":212,"end":218},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23346","span":{"begin":199,"end":205},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23345","span":{"begin":81,"end":87},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23344","span":{"begin":57,"end":63},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23343","span":{"begin":466,"end":471},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23342","span":{"begin":294,"end":299},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23341","span":{"begin":111,"end":116},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23340","span":{"begin":3,"end":8},"obj":"http://www.uniprot.org/uniprot/P01584"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"sentences","denotations":[{"id":"T22966","span":{"begin":1111,"end":1204},"obj":"Sentence"},{"id":"T22965","span":{"begin":1020,"end":1110},"obj":"Sentence"},{"id":"T22964","span":{"begin":803,"end":1019},"obj":"Sentence"},{"id":"T22963","span":{"begin":646,"end":802},"obj":"Sentence"},{"id":"T22962","span":{"begin":559,"end":645},"obj":"Sentence"},{"id":"T22961","span":{"begin":466,"end":558},"obj":"Sentence"},{"id":"T22960","span":{"begin":373,"end":465},"obj":"Sentence"},{"id":"T22959","span":{"begin":245,"end":372},"obj":"Sentence"},{"id":"T22958","span":{"begin":89,"end":244},"obj":"Sentence"},{"id":"T22957","span":{"begin":0,"end":88},"obj":"Sentence"},{"id":"T92","span":{"begin":89,"end":244},"obj":"Sentence"},{"id":"T93","span":{"begin":245,"end":372},"obj":"Sentence"},{"id":"T94","span":{"begin":373,"end":465},"obj":"Sentence"},{"id":"T95","span":{"begin":466,"end":558},"obj":"Sentence"},{"id":"T96","span":{"begin":559,"end":645},"obj":"Sentence"},{"id":"T97","span":{"begin":646,"end":802},"obj":"Sentence"},{"id":"T98","span":{"begin":803,"end":1019},"obj":"Sentence"},{"id":"T99","span":{"begin":1020,"end":1110},"obj":"Sentence"},{"id":"T100","span":{"begin":1111,"end":1204},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"simple1","denotations":[{"id":"T23077","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T23076","span":{"begin":1084,"end":1090},"obj":"Protein"},{"id":"T23075","span":{"begin":990,"end":996},"obj":"Protein"},{"id":"T23074","span":{"begin":918,"end":924},"obj":"Protein"},{"id":"T23073","span":{"begin":868,"end":874},"obj":"Protein"},{"id":"T23072","span":{"begin":770,"end":776},"obj":"Protein"},{"id":"T23071","span":{"begin":757,"end":763},"obj":"Protein"},{"id":"T23070","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T23069","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T23068","span":{"begin":600,"end":606},"obj":"Protein"},{"id":"T23067","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23066","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T23065","span":{"begin":437,"end":443},"obj":"Protein"},{"id":"T23064","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T23063","span":{"begin":326,"end":332},"obj":"Protein"},{"id":"T23062","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T23061","span":{"begin":212,"end":218},"obj":"Protein"},{"id":"T23060","span":{"begin":199,"end":205},"obj":"Protein"},{"id":"T23059","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T23058","span":{"begin":81,"end":87},"obj":"Protein"},{"id":"T23057","span":{"begin":57,"end":63},"obj":"Protein"},{"id":"T23056","span":{"begin":3,"end":8},"obj":"Protein"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T23824","span":{"begin":925,"end":935},"obj":"Gene_expression"},{"id":"T23823","span":{"begin":675,"end":685},"obj":"Gene_expression"},{"id":"T23822","span":{"begin":281,"end":290},"obj":"Negative_regulation"},{"id":"T23821","span":{"begin":300,"end":310},"obj":"Gene_expression"},{"id":"T23820","span":{"begin":117,"end":127},"obj":"Gene_expression"},{"id":"T23819","span":{"begin":13,"end":27},"obj":"Negative_regulation"},{"id":"T23818","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T23817","span":{"begin":1084,"end":1090},"obj":"Protein"},{"id":"T23816","span":{"begin":990,"end":996},"obj":"Protein"},{"id":"T23815","span":{"begin":918,"end":924},"obj":"Protein"},{"id":"T23814","span":{"begin":868,"end":874},"obj":"Protein"},{"id":"T23798","span":{"begin":57,"end":63},"obj":"Protein"},{"id":"T23797","span":{"begin":3,"end":8},"obj":"Protein"},{"id":"T23813","span":{"begin":770,"end":776},"obj":"Protein"},{"id":"T23812","span":{"begin":757,"end":763},"obj":"Protein"},{"id":"T23811","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T23810","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T23809","span":{"begin":600,"end":606},"obj":"Protein"},{"id":"T23808","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23807","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T23806","span":{"begin":437,"end":443},"obj":"Protein"},{"id":"T23805","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T23804","span":{"begin":326,"end":332},"obj":"Protein"},{"id":"T23803","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T23802","span":{"begin":212,"end":218},"obj":"Protein"},{"id":"T23801","span":{"begin":199,"end":205},"obj":"Protein"},{"id":"T23800","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T23799","span":{"begin":81,"end":87},"obj":"Protein"}],"relations":[{"id":"R16234","pred":"themeOf","subj":"T23797","obj":"T23819"},{"id":"R16235","pred":"themeOf","subj":"T23800","obj":"T23820"},{"id":"R16236","pred":"themeOf","subj":"T23803","obj":"T23821"},{"id":"R16237","pred":"themeOf","subj":"T23804","obj":"T23821"},{"id":"R16238","pred":"themeOf","subj":"T23811","obj":"T23823"},{"id":"R16239","pred":"themeOf","subj":"T23815","obj":"T23824"},{"id":"R16240","pred":"themeOf","subj":"T23821","obj":"T23822"},{"id":"R16241","pred":"themeOf","subj":"T23821","obj":"T23822"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T23033","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T23032","span":{"begin":675,"end":685},"obj":"Gene_expression"},{"id":"T23031","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T23030","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T23029","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23028","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T23027","span":{"begin":281,"end":290},"obj":"Negative_regulation"},{"id":"T23026","span":{"begin":300,"end":310},"obj":"Gene_expression"},{"id":"T23025","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T23024","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T23023","span":{"begin":117,"end":127},"obj":"Gene_expression"},{"id":"T23022","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T23021","span":{"begin":13,"end":27},"obj":"Negative_regulation"},{"id":"T23020","span":{"begin":81,"end":87},"obj":"Protein"},{"id":"T23019","span":{"begin":3,"end":8},"obj":"Protein"}],"relations":[{"id":"R15652","pred":"themeOf","subj":"T23019","obj":"T23021"},{"id":"R15653","pred":"themeOf","subj":"T23022","obj":"T23023"},{"id":"R15654","pred":"themeOf","subj":"T23024","obj":"T23026"},{"id":"R15655","pred":"themeOf","subj":"T23026","obj":"T23027"},{"id":"R15656","pred":"themeOf","subj":"T23031","obj":"T23032"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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{"project":"test3","denotations":[{"id":"T22942","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T22941","span":{"begin":437,"end":443},"obj":"Protein"},{"id":"T22940","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T22939","span":{"begin":326,"end":332},"obj":"Protein"},{"id":"T22938","span":{"begin":311,"end":320},"obj":"Positive_regulation"},{"id":"T22937","span":{"begin":300,"end":310},"obj":"Gene_expression"},{"id":"T22936","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T22935","span":{"begin":281,"end":290},"obj":"Negative_regulation"},{"id":"T22934","span":{"begin":212,"end":218},"obj":"Protein"},{"id":"T22933","span":{"begin":199,"end":205},"obj":"Protein"},{"id":"T22932","span":{"begin":117,"end":127},"obj":"Gene_expression"},{"id":"T22931","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T22930","span":{"begin":81,"end":87},"obj":"Protein"},{"id":"T22929","span":{"begin":57,"end":63},"obj":"Protein"},{"id":"T22928","span":{"begin":42,"end":51},"obj":"Positive_regulation"},{"id":"T22927","span":{"begin":13,"end":27},"obj":"Negative_regulation"},{"id":"T22926","span":{"begin":3,"end":8},"obj":"Protein"},{"id":"T22925","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T22924","span":{"begin":1084,"end":1090},"obj":"Protein"},{"id":"T22923","span":{"begin":990,"end":996},"obj":"Protein"},{"id":"T22922","span":{"begin":918,"end":924},"obj":"Protein"},{"id":"T22921","span":{"begin":868,"end":874},"obj":"Protein"},{"id":"T22920","span":{"begin":770,"end":776},"obj":"Protein"},{"id":"T22919","span":{"begin":757,"end":763},"obj":"Protein"},{"id":"T22918","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T22917","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T22916","span":{"begin":600,"end":606},"obj":"Protein"},{"id":"T22915","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T22914","span":{"begin":466,"end":471},"obj":"Protein"},{"id":"T22913","span":{"begin":437,"end":443},"obj":"Protein"},{"id":"T22912","span":{"begin":350,"end":356},"obj":"Protein"},{"id":"T22911","span":{"begin":326,"end":332},"obj":"Protein"},{"id":"T22910","span":{"begin":294,"end":299},"obj":"Protein"},{"id":"T22909","span":{"begin":212,"end":218},"obj":"Protein"},{"id":"T22908","span":{"begin":199,"end":205},"obj":"Protein"},{"id":"T22907","span":{"begin":111,"end":116},"obj":"Protein"},{"id":"T22906","span":{"begin":81,"end":87},"obj":"Protein"},{"id":"T22905","span":{"begin":57,"end":63},"obj":"Protein"},{"id":"T22904","span":{"begin":3,"end":8},"obj":"Protein"},{"id":"T22956","span":{"begin":1111,"end":1117},"obj":"Protein"},{"id":"T22955","span":{"begin":1084,"end":1090},"obj":"Protein"},{"id":"T22954","span":{"begin":990,"end":996},"obj":"Protein"},{"id":"T22953","span":{"begin":925,"end":935},"obj":"Gene_expression"},{"id":"T22952","span":{"begin":918,"end":924},"obj":"Protein"},{"id":"T22951","span":{"begin":868,"end":874},"obj":"Protein"},{"id":"T22950","span":{"begin":770,"end":776},"obj":"Protein"},{"id":"T22949","span":{"begin":757,"end":763},"obj":"Protein"},{"id":"T22948","span":{"begin":675,"end":685},"obj":"Gene_expression"},{"id":"T22947","span":{"begin":668,"end":674},"obj":"Protein"},{"id":"T22946","span":{"begin":638,"end":644},"obj":"Protein"},{"id":"T22945","span":{"begin":600,"end":606},"obj":"Protein"},{"id":"T22944","span":{"begin":585,"end":594},"obj":"Positive_regulation"},{"id":"T22943","span":{"begin":562,"end":568},"obj":"Protein"}],"relations":[{"id":"R15624","pred":"themeOf","subj":"T22926","obj":"T22927"},{"id":"R15625","pred":"causeOf","subj":"T22929","obj":"T22927"},{"id":"R15626","pred":"causeOf","subj":"T22930","obj":"T22927"},{"id":"R15627","pred":"themeOf","subj":"T22931","obj":"T22932"},{"id":"R15628","pred":"themeOf","subj":"T22936","obj":"T22937"},{"id":"R15629","pred":"themeOf","subj":"T22937","obj":"T22935"},{"id":"R15630","pred":"themeOf","subj":"T22937","obj":"T22938"},{"id":"R15631","pred":"causeOf","subj":"T22939","obj":"T22938"},{"id":"R15632","pred":"causeOf","subj":"T22939","obj":"T22935"},{"id":"R15633","pred":"causeOf","subj":"T22940","obj":"T22938"},{"id":"R15634","pred":"causeOf","subj":"T22940","obj":"T22935"},{"id":"R15635","pred":"themeOf","subj":"T22943","obj":"T22944"},{"id":"R15636","pred":"causeOf","subj":"T22945","obj":"T22944"},{"id":"R15637","pred":"causeOf","subj":"T22946","obj":"T22944"},{"id":"R15638","pred":"themeOf","subj":"T22947","obj":"T22948"},{"id":"R15639","pred":"themeOf","subj":"T22952","obj":"T22953"}],"text":"A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}