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3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T23011","span":{"begin":678,"end":684},"obj":"Protein"},{"id":"T23010","span":{"begin":648,"end":654},"obj":"Protein"},{"id":"T23009","span":{"begin":610,"end":616},"obj":"Protein"},{"id":"T23008","span":{"begin":572,"end":578},"obj":"Protein"},{"id":"T23007","span":{"begin":476,"end":481},"obj":"Protein"},{"id":"T23006","span":{"begin":447,"end":453},"obj":"Protein"},{"id":"T23005","span":{"begin":360,"end":366},"obj":"Protein"},{"id":"T23004","span":{"begin":336,"end":342},"obj":"Protein"},{"id":"T23003","span":{"begin":304,"end":309},"obj":"Protein"},{"id":"T23002","span":{"begin":222,"end":228},"obj":"Protein"},{"id":"T23001","span":{"begin":209,"end":215},"obj":"Protein"},{"id":"T23000","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T22999","span":{"begin":91,"end":97},"obj":"Protein"},{"id":"T22998","span":{"begin":67,"end":73},"obj":"Protein"},{"id":"T22997","span":{"begin":13,"end":18},"obj":"Protein"},{"id":"T23018","span":{"begin":1121,"end":1127},"obj":"Protein"},{"id":"T23017","span":{"begin":1094,"end":1100},"obj":"Protein"},{"id":"T23016","span":{"begin":1000,"end":1006},"obj":"Protein"},{"id":"T23015","span":{"begin":928,"end":934},"obj":"Protein"},{"id":"T23014","span":{"begin":878,"end":884},"obj":"Protein"},{"id":"T23013","span":{"begin":780,"end":786},"obj":"Protein"},{"id":"T23012","span":{"begin":767,"end":773},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T23361","span":{"begin":1121,"end":1127},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23360","span":{"begin":928,"end":934},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23359","span":{"begin":678,"end":684},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23358","span":{"begin":572,"end":578},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23357","span":{"begin":1094,"end":1100},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23356","span":{"begin":1000,"end":1006},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23355","span":{"begin":878,"end":884},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23354","span":{"begin":780,"end":786},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23353","span":{"begin":767,"end":773},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23352","span":{"begin":648,"end":654},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23351","span":{"begin":610,"end":616},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23350","span":{"begin":447,"end":453},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23349","span":{"begin":360,"end":366},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23348","span":{"begin":336,"end":342},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23347","span":{"begin":222,"end":228},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23346","span":{"begin":209,"end":215},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23345","span":{"begin":91,"end":97},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23344","span":{"begin":67,"end":73},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23343","span":{"begin":476,"end":481},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23342","span":{"begin":304,"end":309},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23341","span":{"begin":121,"end":126},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23340","span":{"begin":13,"end":18},"obj":"http://www.uniprot.org/uniprot/P01584"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"sentences","denotations":[{"id":"T22966","span":{"begin":1121,"end":1214},"obj":"Sentence"},{"id":"T22965","span":{"begin":1030,"end":1120},"obj":"Sentence"},{"id":"T22964","span":{"begin":813,"end":1029},"obj":"Sentence"},{"id":"T22963","span":{"begin":656,"end":812},"obj":"Sentence"},{"id":"T22962","span":{"begin":569,"end":655},"obj":"Sentence"},{"id":"T22961","span":{"begin":476,"end":568},"obj":"Sentence"},{"id":"T22960","span":{"begin":383,"end":475},"obj":"Sentence"},{"id":"T22959","span":{"begin":255,"end":382},"obj":"Sentence"},{"id":"T22958","span":{"begin":99,"end":254},"obj":"Sentence"},{"id":"T22957","span":{"begin":10,"end":98},"obj":"Sentence"},{"id":"T91","span":{"begin":0,"end":98},"obj":"Sentence"},{"id":"T92","span":{"begin":99,"end":254},"obj":"Sentence"},{"id":"T93","span":{"begin":255,"end":382},"obj":"Sentence"},{"id":"T94","span":{"begin":383,"end":475},"obj":"Sentence"},{"id":"T95","span":{"begin":476,"end":568},"obj":"Sentence"},{"id":"T96","span":{"begin":569,"end":655},"obj":"Sentence"},{"id":"T97","span":{"begin":656,"end":812},"obj":"Sentence"},{"id":"T98","span":{"begin":813,"end":1029},"obj":"Sentence"},{"id":"T99","span":{"begin":1030,"end":1120},"obj":"Sentence"},{"id":"T100","span":{"begin":1121,"end":1214},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"simple1","denotations":[{"id":"T23077","span":{"begin":1121,"end":1127},"obj":"Protein"},{"id":"T23076","span":{"begin":1094,"end":1100},"obj":"Protein"},{"id":"T23075","span":{"begin":1000,"end":1006},"obj":"Protein"},{"id":"T23074","span":{"begin":928,"end":934},"obj":"Protein"},{"id":"T23073","span":{"begin":878,"end":884},"obj":"Protein"},{"id":"T23072","span":{"begin":780,"end":786},"obj":"Protein"},{"id":"T23071","span":{"begin":767,"end":773},"obj":"Protein"},{"id":"T23070","span":{"begin":678,"end":684},"obj":"Protein"},{"id":"T23069","span":{"begin":648,"end":654},"obj":"Protein"},{"id":"T23068","span":{"begin":610,"end":616},"obj":"Protein"},{"id":"T23067","span":{"begin":572,"end":578},"obj":"Protein"},{"id":"T23066","span":{"begin":476,"end":481},"obj":"Protein"},{"id":"T23065","span":{"begin":447,"end":453},"obj":"Protein"},{"id":"T23064","span":{"begin":360,"end":366},"obj":"Protein"},{"id":"T23063","span":{"begin":336,"end":342},"obj":"Protein"},{"id":"T23062","span":{"begin":304,"end":309},"obj":"Protein"},{"id":"T23061","span":{"begin":222,"end":228},"obj":"Protein"},{"id":"T23060","span":{"begin":209,"end":215},"obj":"Protein"},{"id":"T23059","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23058","span":{"begin":91,"end":97},"obj":"Protein"},{"id":"T23057","span":{"begin":67,"end":73},"obj":"Protein"},{"id":"T23056","span":{"begin":13,"end":18},"obj":"Protein"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T23824","span":{"begin":935,"end":945},"obj":"Gene_expression"},{"id":"T23823","span":{"begin":685,"end":695},"obj":"Gene_expression"},{"id":"T23822","span":{"begin":291,"end":300},"obj":"Negative_regulation"},{"id":"T23821","span":{"begin":310,"end":320},"obj":"Gene_expression"},{"id":"T23820","span":{"begin":127,"end":137},"obj":"Gene_expression"},{"id":"T23819","span":{"begin":23,"end":37},"obj":"Negative_regulation"},{"id":"T23818","span":{"begin":1121,"end":1127},"obj":"Protein"},{"id":"T23817","span":{"begin":1094,"end":1100},"obj":"Protein"},{"id":"T23816","span":{"begin":1000,"end":1006},"obj":"Protein"},{"id":"T23815","span":{"begin":928,"end":934},"obj":"Protein"},{"id":"T23814","span":{"begin":878,"end":884},"obj":"Protein"},{"id":"T23798","span":{"begin":67,"end":73},"obj":"Protein"},{"id":"T23797","span":{"begin":13,"end":18},"obj":"Protein"},{"id":"T23813","span":{"begin":780,"end":786},"obj":"Protein"},{"id":"T23812","span":{"begin":767,"end":773},"obj":"Protein"},{"id":"T23811","span":{"begin":678,"end":684},"obj":"Protein"},{"id":"T23810","span":{"begin":648,"end":654},"obj":"Protein"},{"id":"T23809","span":{"begin":610,"end":616},"obj":"Protein"},{"id":"T23808","span":{"begin":572,"end":578},"obj":"Protein"},{"id":"T23807","span":{"begin":476,"end":481},"obj":"Protein"},{"id":"T23806","span":{"begin":447,"end":453},"obj":"Protein"},{"id":"T23805","span":{"begin":360,"end":366},"obj":"Protein"},{"id":"T23804","span":{"begin":336,"end":342},"obj":"Protein"},{"id":"T23803","span":{"begin":304,"end":309},"obj":"Protein"},{"id":"T23802","span":{"begin":222,"end":228},"obj":"Protein"},{"id":"T23801","span":{"begin":209,"end":215},"obj":"Protein"},{"id":"T23800","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23799","span":{"begin":91,"end":97},"obj":"Protein"}],"relations":[{"id":"R16234","pred":"themeOf","subj":"T23797","obj":"T23819"},{"id":"R16235","pred":"themeOf","subj":"T23800","obj":"T23820"},{"id":"R16236","pred":"themeOf","subj":"T23803","obj":"T23821"},{"id":"R16237","pred":"themeOf","subj":"T23804","obj":"T23821"},{"id":"R16238","pred":"themeOf","subj":"T23811","obj":"T23823"},{"id":"R16239","pred":"themeOf","subj":"T23815","obj":"T23824"},{"id":"R16240","pred":"themeOf","subj":"T23821","obj":"T23822"},{"id":"R16241","pred":"themeOf","subj":"T23821","obj":"T23822"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T23033","span":{"begin":1121,"end":1127},"obj":"Protein"},{"id":"T23032","span":{"begin":685,"end":695},"obj":"Gene_expression"},{"id":"T23031","span":{"begin":678,"end":684},"obj":"Protein"},{"id":"T23030","span":{"begin":648,"end":654},"obj":"Protein"},{"id":"T23029","span":{"begin":572,"end":578},"obj":"Protein"},{"id":"T23028","span":{"begin":476,"end":481},"obj":"Protein"},{"id":"T23027","span":{"begin":291,"end":300},"obj":"Negative_regulation"},{"id":"T23026","span":{"begin":310,"end":320},"obj":"Gene_expression"},{"id":"T23025","span":{"begin":360,"end":366},"obj":"Protein"},{"id":"T23024","span":{"begin":304,"end":309},"obj":"Protein"},{"id":"T23023","span":{"begin":127,"end":137},"obj":"Gene_expression"},{"id":"T23022","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T23021","span":{"begin":23,"end":37},"obj":"Negative_regulation"},{"id":"T23020","span":{"begin":91,"end":97},"obj":"Protein"},{"id":"T23019","span":{"begin":13,"end":18},"obj":"Protein"}],"relations":[{"id":"R15652","pred":"themeOf","subj":"T23019","obj":"T23021"},{"id":"R15653","pred":"themeOf","subj":"T23022","obj":"T23023"},{"id":"R15654","pred":"themeOf","subj":"T23024","obj":"T23026"},{"id":"R15655","pred":"themeOf","subj":"T23026","obj":"T23027"},{"id":"R15656","pred":"themeOf","subj":"T23031","obj":"T23032"}],"text":"Figure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}