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An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A)."}

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{"project":"testone","denotations":[{"id":"T4427","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T4426","span":{"begin":430,"end":436},"obj":"Protein"},{"id":"T4425","span":{"begin":348,"end":354},"obj":"Protein"},{"id":"T4424","span":{"begin":310,"end":316},"obj":"Protein"},{"id":"T4423","span":{"begin":241,"end":246},"obj":"Protein"},{"id":"T4422","span":{"begin":198,"end":204},"obj":"Protein"},{"id":"T4421","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T4420","span":{"begin":13,"end":18},"obj":"Protein"},{"id":"T4491","span":{"begin":437,"end":444},"obj":"Positive_regulation"},{"id":"T4490","span":{"begin":413,"end":422},"obj":"Negative_regulation"},{"id":"T4489","span":{"begin":228,"end":237},"obj":"Negative_regulation"},{"id":"T4488","span":{"begin":128,"end":138},"obj":"Gene_expression"},{"id":"T4487","span":{"begin":105,"end":118},"obj":"Positive_regulation"},{"id":"T4486","span":{"begin":41,"end":50},"obj":"Positive_regulation"},{"id":"T4485","span":{"begin":19,"end":29},"obj":"Gene_expression"}],"relations":[{"id":"R2720","pred":"themeOf","subj":"T4420","obj":"T4485"},{"id":"R2721","pred":"themeOf","subj":"T4421","obj":"T4488"},{"id":"R2722","pred":"themeOf","subj":"T4423","obj":"T4489"},{"id":"R2723","pred":"causeOf","subj":"T4424","obj":"T4489"},{"id":"R2724","pred":"causeOf","subj":"T4426","obj":"T4491"},{"id":"R2725","pred":"themeOf","subj":"T4427","obj":"T4491"},{"id":"R2768","pred":"themeOf","subj":"T4485","obj":"T4486"},{"id":"R2769","pred":"themeOf","subj":"T4488","obj":"T4487"},{"id":"R2770","pred":"themeOf","subj":"T4491","obj":"T4490"}],"text":"There was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A)."}

{"project":"test3","denotations":[{"id":"T4630","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T4629","span":{"begin":437,"end":444},"obj":"Positive_regulation"},{"id":"T4628","span":{"begin":430,"end":436},"obj":"Protein"},{"id":"T4627","span":{"begin":413,"end":422},"obj":"Negative_regulation"},{"id":"T4626","span":{"begin":348,"end":354},"obj":"Protein"},{"id":"T4625","span":{"begin":310,"end":316},"obj":"Protein"},{"id":"T4624","span":{"begin":241,"end":246},"obj":"Protein"},{"id":"T4623","span":{"begin":228,"end":237},"obj":"Negative_regulation"},{"id":"T4622","span":{"begin":198,"end":204},"obj":"Protein"},{"id":"T4621","span":{"begin":128,"end":138},"obj":"Gene_expression"},{"id":"T4620","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T4619","span":{"begin":105,"end":118},"obj":"Positive_regulation"},{"id":"T4618","span":{"begin":41,"end":50},"obj":"Positive_regulation"},{"id":"T4617","span":{"begin":19,"end":29},"obj":"Gene_expression"},{"id":"T4616","span":{"begin":13,"end":18},"obj":"Protein"},{"id":"T4548","span":{"begin":455,"end":460},"obj":"Protein"},{"id":"T4547","span":{"begin":430,"end":436},"obj":"Protein"},{"id":"T4546","span":{"begin":348,"end":354},"obj":"Protein"},{"id":"T4545","span":{"begin":310,"end":316},"obj":"Protein"},{"id":"T4544","span":{"begin":241,"end":246},"obj":"Protein"},{"id":"T4543","span":{"begin":198,"end":204},"obj":"Protein"},{"id":"T4542","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T4541","span":{"begin":13,"end":18},"obj":"Protein"}],"relations":[{"id":"R2797","pred":"themeOf","subj":"T4616","obj":"T4617"},{"id":"R2798","pred":"themeOf","subj":"T4617","obj":"T4618"},{"id":"R2799","pred":"themeOf","subj":"T4620","obj":"T4621"},{"id":"R2800","pred":"themeOf","subj":"T4621","obj":"T4619"},{"id":"R2801","pred":"themeOf","subj":"T4624","obj":"T4623"},{"id":"R2802","pred":"causeOf","subj":"T4625","obj":"T4623"},{"id":"R2803","pred":"causeOf","subj":"T4628","obj":"T4629"},{"id":"R2804","pred":"themeOf","subj":"T4629","obj":"T4627"},{"id":"R2805","pred":"themeOf","subj":"T4630","obj":"T4629"}],"text":"There was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A)."}