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IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T4940","span":{"begin":465,"end":470},"obj":"Protein"},{"id":"T4939","span":{"begin":440,"end":446},"obj":"Protein"},{"id":"T4938","span":{"begin":358,"end":364},"obj":"Protein"},{"id":"T4937","span":{"begin":320,"end":326},"obj":"Protein"},{"id":"T4936","span":{"begin":251,"end":256},"obj":"Protein"},{"id":"T4935","span":{"begin":208,"end":214},"obj":"Protein"},{"id":"T4934","span":{"begin":132,"end":137},"obj":"Protein"},{"id":"T4933","span":{"begin":23,"end":28},"obj":"Protein"},{"id":"T4932","span":{"begin":4,"end":9},"obj":"Protein"},{"id":"T23011","span":{"begin":1173,"end":1179},"obj":"Protein"},{"id":"T23010","span":{"begin":1143,"end":1149},"obj":"Protein"},{"id":"T23009","span":{"begin":1105,"end":1111},"obj":"Protein"},{"id":"T23008","span":{"begin":1067,"end":1073},"obj":"Protein"},{"id":"T23007","span":{"begin":971,"end":976},"obj":"Protein"},{"id":"T23006","span":{"begin":942,"end":948},"obj":"Protein"},{"id":"T23005","span":{"begin":855,"end":861},"obj":"Protein"},{"id":"T23004","span":{"begin":831,"end":837},"obj":"Protein"},{"id":"T23003","span":{"begin":799,"end":804},"obj":"Protein"},{"id":"T23002","span":{"begin":717,"end":723},"obj":"Protein"},{"id":"T23001","span":{"begin":704,"end":710},"obj":"Protein"},{"id":"T23000","span":{"begin":616,"end":621},"obj":"Protein"},{"id":"T22999","span":{"begin":586,"end":592},"obj":"Protein"},{"id":"T22998","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T22997","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T23018","span":{"begin":1616,"end":1622},"obj":"Protein"},{"id":"T23017","span":{"begin":1589,"end":1595},"obj":"Protein"},{"id":"T23016","span":{"begin":1495,"end":1501},"obj":"Protein"},{"id":"T23015","span":{"begin":1423,"end":1429},"obj":"Protein"},{"id":"T23014","span":{"begin":1373,"end":1379},"obj":"Protein"},{"id":"T23013","span":{"begin":1275,"end":1281},"obj":"Protein"},{"id":"T23012","span":{"begin":1262,"end":1268},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T23361","span":{"begin":1616,"end":1622},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23360","span":{"begin":1423,"end":1429},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23359","span":{"begin":1173,"end":1179},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23358","span":{"begin":1067,"end":1073},"obj":"http://www.uniprot.org/uniprot/P18510"},{"id":"T23357","span":{"begin":1589,"end":1595},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23356","span":{"begin":1495,"end":1501},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23355","span":{"begin":1373,"end":1379},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23354","span":{"begin":1275,"end":1281},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23353","span":{"begin":1262,"end":1268},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23352","span":{"begin":1143,"end":1149},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23351","span":{"begin":1105,"end":1111},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23350","span":{"begin":942,"end":948},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23349","span":{"begin":855,"end":861},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23348","span":{"begin":831,"end":837},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23347","span":{"begin":717,"end":723},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23346","span":{"begin":704,"end":710},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23345","span":{"begin":586,"end":592},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23344","span":{"begin":562,"end":568},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T23343","span":{"begin":971,"end":976},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23342","span":{"begin":799,"end":804},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23341","span":{"begin":616,"end":621},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T23340","span":{"begin":508,"end":513},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6076","span":{"begin":465,"end":470},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6075","span":{"begin":251,"end":256},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6074","span":{"begin":132,"end":137},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6073","span":{"begin":23,"end":28},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6072","span":{"begin":4,"end":9},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T6031","span":{"begin":440,"end":446},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T6030","span":{"begin":358,"end":364},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T6029","span":{"begin":320,"end":326},"obj":"http://www.uniprot.org/uniprot/P06886"},{"id":"T6028","span":{"begin":208,"end":214},"obj":"http://www.uniprot.org/uniprot/P06886"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"GO-BP","denotations":[{"id":"T4757","span":{"begin":118,"end":128},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"sentences","denotations":[{"id":"T22966","span":{"begin":1616,"end":1709},"obj":"Sentence"},{"id":"T22965","span":{"begin":1525,"end":1615},"obj":"Sentence"},{"id":"T22964","span":{"begin":1308,"end":1524},"obj":"Sentence"},{"id":"T22963","span":{"begin":1151,"end":1307},"obj":"Sentence"},{"id":"T22962","span":{"begin":1064,"end":1150},"obj":"Sentence"},{"id":"T22961","span":{"begin":971,"end":1063},"obj":"Sentence"},{"id":"T22960","span":{"begin":878,"end":970},"obj":"Sentence"},{"id":"T22959","span":{"begin":750,"end":877},"obj":"Sentence"},{"id":"T22958","span":{"begin":594,"end":749},"obj":"Sentence"},{"id":"T22957","span":{"begin":505,"end":593},"obj":"Sentence"},{"id":"T4727","span":{"begin":395,"end":494},"obj":"Sentence"},{"id":"T4726","span":{"begin":199,"end":394},"obj":"Sentence"},{"id":"T4725","span":{"begin":98,"end":198},"obj":"Sentence"},{"id":"T4724","span":{"begin":10,"end":97},"obj":"Sentence"},{"id":"T4723","span":{"begin":0,"end":9},"obj":"Sentence"},{"id":"T86","span":{"begin":0,"end":9},"obj":"Sentence"},{"id":"T87","span":{"begin":10,"end":97},"obj":"Sentence"},{"id":"T88","span":{"begin":98,"end":198},"obj":"Sentence"},{"id":"T89","span":{"begin":199,"end":394},"obj":"Sentence"},{"id":"T90","span":{"begin":395,"end":494},"obj":"Sentence"},{"id":"T91","span":{"begin":495,"end":593},"obj":"Sentence"},{"id":"T92","span":{"begin":594,"end":749},"obj":"Sentence"},{"id":"T93","span":{"begin":750,"end":877},"obj":"Sentence"},{"id":"T94","span":{"begin":878,"end":970},"obj":"Sentence"},{"id":"T95","span":{"begin":971,"end":1063},"obj":"Sentence"},{"id":"T96","span":{"begin":1064,"end":1150},"obj":"Sentence"},{"id":"T97","span":{"begin":1151,"end":1307},"obj":"Sentence"},{"id":"T98","span":{"begin":1308,"end":1524},"obj":"Sentence"},{"id":"T99","span":{"begin":1525,"end":1615},"obj":"Sentence"},{"id":"T100","span":{"begin":1616,"end":1709},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"simple1","denotations":[{"id":"T23077","span":{"begin":1616,"end":1622},"obj":"Protein"},{"id":"T23076","span":{"begin":1589,"end":1595},"obj":"Protein"},{"id":"T23075","span":{"begin":1495,"end":1501},"obj":"Protein"},{"id":"T23074","span":{"begin":1423,"end":1429},"obj":"Protein"},{"id":"T23073","span":{"begin":1373,"end":1379},"obj":"Protein"},{"id":"T23072","span":{"begin":1275,"end":1281},"obj":"Protein"},{"id":"T23071","span":{"begin":1262,"end":1268},"obj":"Protein"},{"id":"T23070","span":{"begin":1173,"end":1179},"obj":"Protein"},{"id":"T23069","span":{"begin":1143,"end":1149},"obj":"Protein"},{"id":"T23068","span":{"begin":1105,"end":1111},"obj":"Protein"},{"id":"T23067","span":{"begin":1067,"end":1073},"obj":"Protein"},{"id":"T23066","span":{"begin":971,"end":976},"obj":"Protein"},{"id":"T23065","span":{"begin":942,"end":948},"obj":"Protein"},{"id":"T23064","span":{"begin":855,"end":861},"obj":"Protein"},{"id":"T23063","span":{"begin":831,"end":837},"obj":"Protein"},{"id":"T23062","span":{"begin":799,"end":804},"obj":"Protein"},{"id":"T23061","span":{"begin":717,"end":723},"obj":"Protein"},{"id":"T23060","span":{"begin":704,"end":710},"obj":"Protein"},{"id":"T23059","span":{"begin":616,"end":621},"obj":"Protein"},{"id":"T23058","span":{"begin":586,"end":592},"obj":"Protein"},{"id":"T23057","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23056","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T5117","span":{"begin":465,"end":470},"obj":"Protein"},{"id":"T5116","span":{"begin":440,"end":446},"obj":"Protein"},{"id":"T5115","span":{"begin":358,"end":364},"obj":"Protein"},{"id":"T5114","span":{"begin":320,"end":326},"obj":"Protein"},{"id":"T5113","span":{"begin":251,"end":256},"obj":"Protein"},{"id":"T5112","span":{"begin":208,"end":214},"obj":"Protein"},{"id":"T5111","span":{"begin":132,"end":137},"obj":"Protein"},{"id":"T5110","span":{"begin":23,"end":28},"obj":"Protein"},{"id":"T5109","span":{"begin":4,"end":9},"obj":"Protein"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T23824","span":{"begin":1430,"end":1440},"obj":"Gene_expression"},{"id":"T23823","span":{"begin":1180,"end":1190},"obj":"Gene_expression"},{"id":"T23822","span":{"begin":786,"end":795},"obj":"Negative_regulation"},{"id":"T23821","span":{"begin":805,"end":815},"obj":"Gene_expression"},{"id":"T23820","span":{"begin":622,"end":632},"obj":"Gene_expression"},{"id":"T23819","span":{"begin":518,"end":532},"obj":"Negative_regulation"},{"id":"T23818","span":{"begin":1616,"end":1622},"obj":"Protein"},{"id":"T23817","span":{"begin":1589,"end":1595},"obj":"Protein"},{"id":"T23816","span":{"begin":1495,"end":1501},"obj":"Protein"},{"id":"T23815","span":{"begin":1423,"end":1429},"obj":"Protein"},{"id":"T23814","span":{"begin":1373,"end":1379},"obj":"Protein"},{"id":"T23798","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23797","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T7727","span":{"begin":423,"end":432},"obj":"Negative_regulation"},{"id":"T7726","span":{"begin":447,"end":454},"obj":"Positive_regulation"},{"id":"T7725","span":{"begin":238,"end":247},"obj":"Negative_regulation"},{"id":"T7724","span":{"begin":115,"end":128},"obj":"Positive_regulation"},{"id":"T7723","span":{"begin":138,"end":148},"obj":"Gene_expression"},{"id":"T7722","span":{"begin":29,"end":39},"obj":"Gene_expression"},{"id":"T7664","span":{"begin":465,"end":470},"obj":"Protein"},{"id":"T7663","span":{"begin":440,"end":446},"obj":"Protein"},{"id":"T7662","span":{"begin":358,"end":364},"obj":"Protein"},{"id":"T7661","span":{"begin":320,"end":326},"obj":"Protein"},{"id":"T7660","span":{"begin":251,"end":256},"obj":"Protein"},{"id":"T7659","span":{"begin":208,"end":214},"obj":"Protein"},{"id":"T7658","span":{"begin":132,"end":137},"obj":"Protein"},{"id":"T7657","span":{"begin":23,"end":28},"obj":"Protein"},{"id":"T7656","span":{"begin":4,"end":9},"obj":"Protein"},{"id":"T23813","span":{"begin":1275,"end":1281},"obj":"Protein"},{"id":"T23812","span":{"begin":1262,"end":1268},"obj":"Protein"},{"id":"T23811","span":{"begin":1173,"end":1179},"obj":"Protein"},{"id":"T23810","span":{"begin":1143,"end":1149},"obj":"Protein"},{"id":"T23809","span":{"begin":1105,"end":1111},"obj":"Protein"},{"id":"T23808","span":{"begin":1067,"end":1073},"obj":"Protein"},{"id":"T23807","span":{"begin":971,"end":976},"obj":"Protein"},{"id":"T23806","span":{"begin":942,"end":948},"obj":"Protein"},{"id":"T23805","span":{"begin":855,"end":861},"obj":"Protein"},{"id":"T23804","span":{"begin":831,"end":837},"obj":"Protein"},{"id":"T23803","span":{"begin":799,"end":804},"obj":"Protein"},{"id":"T23802","span":{"begin":717,"end":723},"obj":"Protein"},{"id":"T23801","span":{"begin":704,"end":710},"obj":"Protein"},{"id":"T23800","span":{"begin":616,"end":621},"obj":"Protein"},{"id":"T23799","span":{"begin":586,"end":592},"obj":"Protein"}],"relations":[{"id":"R16234","pred":"themeOf","subj":"T23797","obj":"T23819"},{"id":"R16235","pred":"themeOf","subj":"T23800","obj":"T23820"},{"id":"R16236","pred":"themeOf","subj":"T23803","obj":"T23821"},{"id":"R16237","pred":"themeOf","subj":"T23804","obj":"T23821"},{"id":"R16238","pred":"themeOf","subj":"T23811","obj":"T23823"},{"id":"R16239","pred":"themeOf","subj":"T23815","obj":"T23824"},{"id":"R16240","pred":"themeOf","subj":"T23821","obj":"T23822"},{"id":"R16241","pred":"themeOf","subj":"T23821","obj":"T23822"},{"id":"R4990","pred":"themeOf","subj":"T7657","obj":"T7722"},{"id":"R4991","pred":"themeOf","subj":"T7658","obj":"T7723"},{"id":"R4996","pred":"themeOf","subj":"T7660","obj":"T7725"},{"id":"R4998","pred":"causeOf","subj":"T7663","obj":"T7726"},{"id":"R5002","pred":"themeOf","subj":"T7664","obj":"T7726"},{"id":"R5003","pred":"themeOf","subj":"T7664","obj":"T7727"},{"id":"R5018","pred":"themeOf","subj":"T7723","obj":"T7724"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T23390","span":{"begin":1430,"end":1440},"obj":"Gene_expression"},{"id":"T23389","span":{"begin":1180,"end":1190},"obj":"Gene_expression"},{"id":"T23388","span":{"begin":786,"end":795},"obj":"Negative_regulation"},{"id":"T23387","span":{"begin":805,"end":815},"obj":"Gene_expression"},{"id":"T23386","span":{"begin":816,"end":825},"obj":"Positive_regulation"},{"id":"T23385","span":{"begin":622,"end":632},"obj":"Gene_expression"},{"id":"T23384","span":{"begin":518,"end":532},"obj":"Negative_regulation"},{"id":"T23383","span":{"begin":1616,"end":1622},"obj":"Protein"},{"id":"T23382","span":{"begin":1589,"end":1595},"obj":"Protein"},{"id":"T23381","span":{"begin":1495,"end":1501},"obj":"Protein"},{"id":"T23380","span":{"begin":1423,"end":1429},"obj":"Protein"},{"id":"T23379","span":{"begin":1373,"end":1379},"obj":"Protein"},{"id":"T23378","span":{"begin":1275,"end":1281},"obj":"Protein"},{"id":"T23377","span":{"begin":1262,"end":1268},"obj":"Protein"},{"id":"T23376","span":{"begin":1173,"end":1179},"obj":"Protein"},{"id":"T23375","span":{"begin":1143,"end":1149},"obj":"Protein"},{"id":"T23374","span":{"begin":1105,"end":1111},"obj":"Protein"},{"id":"T23373","span":{"begin":1067,"end":1073},"obj":"Protein"},{"id":"T23372","span":{"begin":971,"end":976},"obj":"Protein"},{"id":"T23371","span":{"begin":942,"end":948},"obj":"Protein"},{"id":"T23370","span":{"begin":855,"end":861},"obj":"Protein"},{"id":"T23369","span":{"begin":831,"end":837},"obj":"Protein"},{"id":"T23368","span":{"begin":799,"end":804},"obj":"Protein"},{"id":"T23367","span":{"begin":717,"end":723},"obj":"Protein"},{"id":"T23366","span":{"begin":704,"end":710},"obj":"Protein"},{"id":"T23365","span":{"begin":616,"end":621},"obj":"Protein"},{"id":"T23364","span":{"begin":586,"end":592},"obj":"Protein"},{"id":"T23363","span":{"begin":562,"end":568},"obj":"Protein"},{"id":"T23362","span":{"begin":508,"end":513},"obj":"Protein"},{"id":"T6114","span":{"begin":465,"end":470},"obj":"Protein"},{"id":"T6113","span":{"begin":440,"end":446},"obj":"Protein"},{"id":"T6112","span":{"begin":358,"end":364},"obj":"Protein"},{"id":"T6111","span":{"begin":320,"end":326},"obj":"Protein"},{"id":"T6110","span":{"begin":251,"end":256},"obj":"Protein"},{"id":"T6109","span":{"begin":208,"end":214},"obj":"Protein"},{"id":"T6108","span":{"begin":132,"end":137},"obj":"Protein"},{"id":"T6107","span":{"begin":23,"end":28},"obj":"Protein"},{"id":"T6106","span":{"begin":4,"end":9},"obj":"Protein"},{"id":"T6177","span":{"begin":423,"end":432},"obj":"Negative_regulation"},{"id":"T6176","span":{"begin":447,"end":454},"obj":"Positive_regulation"},{"id":"T6175","span":{"begin":238,"end":247},"obj":"Negative_regulation"},{"id":"T6174","span":{"begin":138,"end":148},"obj":"Gene_expression"},{"id":"T6173","span":{"begin":115,"end":128},"obj":"Positive_regulation"},{"id":"T6172","span":{"begin":29,"end":39},"obj":"Gene_expression"}],"relations":[{"id":"R15922","pred":"themeOf","subj":"T23362","obj":"T23384"},{"id":"R15923","pred":"themeOf","subj":"T23365","obj":"T23385"},{"id":"R15924","pred":"themeOf","subj":"T23368","obj":"T23387"},{"id":"R15925","pred":"themeOf","subj":"T23376","obj":"T23389"},{"id":"R15926","pred":"themeOf","subj":"T23380","obj":"T23390"},{"id":"R15927","pred":"themeOf","subj":"T23387","obj":"T23388"},{"id":"R15928","pred":"themeOf","subj":"T23387","obj":"T23386"},{"id":"R3810","pred":"themeOf","subj":"T6107","obj":"T6172"},{"id":"R3811","pred":"themeOf","subj":"T6108","obj":"T6174"},{"id":"R3812","pred":"themeOf","subj":"T6110","obj":"T6175"},{"id":"R3813","pred":"causeOf","subj":"T6113","obj":"T6176"},{"id":"R3814","pred":"themeOf","subj":"T6114","obj":"T6176"},{"id":"R3815","pred":"themeOf","subj":"T6114","obj":"T6177"},{"id":"R3838","pred":"themeOf","subj":"T6174","obj":"T6173"},{"id":"R3840","pred":"themeOf","subj":"T6176","obj":"T6177"}],"text":"(i) IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}

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IL-1β\nThere was no IL-1β production detectable following PBMC treatment with 1 nor 100 μg GP. An insignificant up-regulation of IL-1β production for GP + LPS was observed in comparison with LPS. For GP + TSST-1 we found a significant reduction in IL-1β from 18 h – 24 h, for the latter by about 40% when compared to TSST-1 or the theoretical value of GP/TSST-1 calc. (n = 6; both p = 0.01). On the whole, GP mediated a reduction of the TSST-1-induced amount of IL-1β by about 50% (Fig. 3A).\nFigure 3 A, IL-1β was down-regulated (12 h – 24 h) following GP + TSST-1 when compared to TSST-1. Time course (48 h) of IL-1β production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. At 18 h and 24 h there was a marked reduction in IL-1β production following GP + TSST-1 when compared to TSST-1 (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are also shown. IL-1β levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3). B, IL-1RA was exaggerated following GP + TSST-1 (12 h – 48 h) when compared to TSST-1. Time course (48 h) of IL-1RA production (pg/ml) by human PBMC incubated with medium control, 100 μg GP, 250 ng TSST-1, GP + TSST-1, 250 ng LPS and GP + LPS. Between 18 h and 48 h a simultaneous treatment of PBMC with GP + TSST-1 led to a synergistic effect, i.e. a higher IL-1RA production when compared to an addition of the single values for TSST-1 and GP (* = p \u003c 0.05). Graphs depicting the theoretical values for GP/LPS calc. and GP/TSST-1 calc. are included. IL-1RA levels in the supernatnant were obtained by Elisa and are shown as mean ± SEM (n = 3)."}