PMC:1459172 / 2882-3547 JSONTXT

{"project":"2_test","denotations":[{"id":"16722605-9501905-1692544","span":{"begin":422,"end":424},"obj":"9501905"}],"text":"RNA-RNA binding occurs by formation of stacked intermolecular base pairs, which of course compete with the propensity of both interacting partners to form intramolecular base pairs. These base pairing patterns, usually referred to as secondary structures, not only comprise the dominating part of the energetics of structure formation, they also appear as intermediates in the formation of the tertiary structure of RNAs [25], and they are in many cases well conserved in evolution. Consequently, secondary structures provide a convenient, and computationally tractable, approximation not only to RNA structure but also to the thermodynamics of RNA-RNA interaction."}