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PMC:1448208 / 966-1723 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T1010 0-7 NNS denotes Results
T1011 7-140 sentence denotes By disrupting the E2 subunit gene of branched-chain keto acid dehydrogenase, we created a gene knockout mouse model of classic MSUD.
T1012 8-10 IN denotes By
T1013 88-95 VBD denotes created
T1014 11-21 VBG denotes disrupting
T1015 22-25 DT denotes the
T1016 37-41 NN denotes gene
T1017 26-28 NN denotes E2
T1018 29-36 NN denotes subunit
T1019 42-44 IN denotes of
T1020 45-53 VBN denotes branched
T1021 54-59 NN denotes chain
T1022 53-54 HYPH denotes -
T1023 70-83 NN denotes dehydrogenase
T1024 60-64 NN denotes keto
T1025 65-69 NN denotes acid
T1026 83-85 , denotes ,
T1027 85-87 PRP denotes we
T1028 96-97 DT denotes a
T1029 118-123 NN denotes model
T1030 98-102 NN denotes gene
T1031 103-111 NN denotes knockout
T1032 112-117 NN denotes mouse
T1033 124-126 IN denotes of
T1034 127-134 JJ denotes classic
T1035 135-139 NN denotes MSUD
T1036 139-140 . denotes .
T1037 140-315 sentence denotes The homozygous knockout mice lacked branched-chain keto acid dehydrogenase activity, E2 immunoreactivity, and had a 3-fold increase in circulating branched-chain amino acids.
T1038 141-144 DT denotes The
T1039 165-169 NNS denotes mice
T1040 145-155 JJ denotes homozygous
T1041 156-164 NN denotes knockout
T1042 170-176 VBD denotes lacked
T1043 177-185 VBN denotes branched
T1044 186-191 NN denotes chain
T1045 185-186 HYPH denotes -
T1046 202-215 NN denotes dehydrogenase
T1047 192-196 NN denotes keto
T1048 197-201 NN denotes acid
T1049 216-224 NN denotes activity
T1050 224-226 , denotes ,
T1051 226-228 NN denotes E2
T1052 229-245 NN denotes immunoreactivity
T1053 245-247 , denotes ,
T1054 247-250 CC denotes and
T1055 251-254 VBD denotes had
T1056 255-256 DT denotes a
T1057 264-272 NN denotes increase
T1058 257-258 CD denotes 3
T1059 258-259 HYPH denotes -
T1060 259-263 JJ denotes fold
T1061 273-275 IN denotes in
T1062 276-287 VBG denotes circulating
T1063 309-314 NNS denotes acids
T1064 288-296 VBN denotes branched
T1065 297-302 NN denotes chain
T1066 296-297 HYPH denotes -
T1067 303-308 NN denotes amino
T1068 314-315 . denotes .
T1069 315-376 sentence denotes These metabolic derangements resulted in neonatal lethality.
T1070 316-321 DT denotes These
T1071 332-344 NNS denotes derangements
T1072 322-331 JJ denotes metabolic
T1073 345-353 VBD denotes resulted
T1074 354-356 IN denotes in
T1075 357-365 JJ denotes neonatal
T1076 366-375 NN denotes lethality
T1077 375-376 . denotes .
T1078 376-496 sentence denotes Transgenic expression of a human E2 cDNA in the liver of the E2 knockout animals produced a model of intermediate MSUD.
T1079 377-387 JJ denotes Transgenic
T1080 388-398 NN denotes expression
T1081 458-466 VBD denotes produced
T1082 399-401 IN denotes of
T1083 402-403 DT denotes a
T1084 413-417 NN denotes cDNA
T1085 404-409 JJ denotes human
T1086 410-412 NN denotes E2
T1087 418-420 IN denotes in
T1088 421-424 DT denotes the
T1089 425-430 NN denotes liver
T1090 431-433 IN denotes of
T1091 434-437 DT denotes the
T1092 450-457 NNS denotes animals
T1093 438-440 NN denotes E2
T1094 441-449 NN denotes knockout
T1095 467-468 DT denotes a
T1096 469-474 NN denotes model
T1097 475-477 IN denotes of
T1098 478-490 JJ denotes intermediate
T1099 491-495 NN denotes MSUD
T1100 495-496 . denotes .
T1101 496-757 sentence denotes Branched-chain keto acid dehydrogenase activity was 5–6% of normal and was sufficient to allow survival, but was insufficient to normalize circulating branched-chain amino acids levels, which were intermediate between wildtype and the classic MSUD mouse model.
T1102 497-505 VBN denotes Branched
T1103 506-511 NN denotes chain
T1104 505-506 HYPH denotes -
T1105 522-535 NN denotes dehydrogenase
T1106 512-516 NN denotes keto
T1107 517-521 NN denotes acid
T1108 536-544 NN denotes activity
T1109 545-548 VBD denotes was
T1110 549-550 CD denotes 5
T1111 551-552 CD denotes 6
T1112 550-551 SYM denotes –
T1113 552-553 NN denotes %
T1114 554-556 IN denotes of
T1115 557-563 JJ denotes normal
T1116 564-567 CC denotes and
T1117 568-571 VBD denotes was
T1118 572-582 JJ denotes sufficient
T1119 583-585 TO denotes to
T1120 586-591 VB denotes allow
T1121 592-600 NN denotes survival
T1122 600-602 , denotes ,
T1123 602-605 CC denotes but
T1124 606-609 VBD denotes was
T1125 610-622 JJ denotes insufficient
T1126 623-625 TO denotes to
T1127 636-647 VBG denotes circulating
T1128 626-635 VB denotes normalize
T1129 648-656 VBN denotes branched
T1130 657-662 NN denotes chain
T1131 656-657 HYPH denotes -
T1132 669-674 NNS denotes acids
T1133 663-668 NN denotes amino
T1134 675-681 NNS denotes levels
T1135 681-683 , denotes ,
T1136 683-688 WDT denotes which
T1137 689-693 VBD denotes were
T1138 694-706 JJ denotes intermediate
T1139 707-714 IN denotes between
T1140 715-723 NN denotes wildtype
T1141 724-727 CC denotes and
T1142 728-731 DT denotes the
T1143 751-756 NN denotes model
T1144 732-739 JJ denotes classic
T1145 740-744 NN denotes MSUD
T1146 745-750 NN denotes mouse
T1147 756-757 . denotes .
R154 T1012 T1013 prep By,created
R155 T1014 T1012 pcomp disrupting,By
R156 T1015 T1016 det the,gene
R157 T1016 T1014 dobj gene,disrupting
R160 T1019 T1016 prep of,gene
R161 T1020 T1021 amod branched,chain
R162 T1021 T1023 compound chain,dehydrogenase
R164 T1023 T1019 pobj dehydrogenase,of
R167 T1026 T1013 punct ", ",created
R168 T1027 T1013 nsubj we,created
R169 T1028 T1029 det a,model
R170 T1029 T1013 dobj model,created
R174 T1033 T1029 prep of,model
R175 T1034 T1035 amod classic,MSUD
R176 T1035 T1033 pobj MSUD,of
R177 T1036 T1013 punct .,created
R178 T1038 T1039 det The,mice
R179 T1039 T1042 nsubj mice,lacked
R182 T1043 T1044 amod branched,chain
R183 T1044 T1046 compound chain,dehydrogenase
R185 T1046 T1049 compound dehydrogenase,activity
R188 T1049 T1042 dobj activity,lacked
R189 T1050 T1049 punct ", ",activity
R190 T1051 T1052 compound E2,immunoreactivity
R191 T1052 T1049 appos immunoreactivity,activity
R192 T1053 T1042 punct ", ",lacked
R193 T1054 T1042 cc and,lacked
R194 T1055 T1042 conj had,lacked
R195 T1056 T1057 det a,increase
R196 T1057 T1055 dobj increase,had
R200 T1061 T1057 prep in,increase
R201 T1062 T1063 amod circulating,acids
R202 T1063 T1061 pobj acids,in
R204 T1065 T1063 compound chain,acids
R205 T1066 T1065 punct -,chain
R207 T1068 T1042 punct .,lacked
R208 T1070 T1071 det These,derangements
R209 T1071 T1073 nsubj derangements,resulted
R211 T1074 T1073 prep in,resulted
R212 T1075 T1076 amod neonatal,lethality
R213 T1076 T1074 pobj lethality,in
R214 T1077 T1073 punct .,resulted
R215 T1079 T1080 amod Transgenic,expression
R216 T1080 T1081 nsubj expression,produced
R217 T1082 T1080 prep of,expression
R218 T1083 T1084 det a,cDNA
R219 T1084 T1082 pobj cDNA,of
R222 T1087 T1080 prep in,expression
R223 T1088 T1089 det the,liver
R224 T1089 T1087 pobj liver,in
R225 T1090 T1089 prep of,liver
R226 T1091 T1092 det the,animals
R227 T1092 T1090 pobj animals,of
R230 T1095 T1096 det a,model
R231 T1096 T1081 dobj model,produced
R232 T1097 T1096 prep of,model
R233 T1098 T1099 amod intermediate,MSUD
R234 T1099 T1097 pobj MSUD,of
R235 T1100 T1081 punct .,produced
R236 T1102 T1103 amod Branched,chain
R237 T1103 T1105 compound chain,dehydrogenase
R239 T1105 T1108 compound dehydrogenase,activity
R242 T1108 T1109 nsubj activity,was
R243 T1110 T1111 quantmod 5,6
R244 T1111 T1113 nummod 6,%
R246 T1113 T1109 attr %,was
R247 T1114 T1113 prep of,%
R248 T1115 T1114 amod normal,of
R249 T1116 T1109 cc and,was
R250 T1117 T1109 conj was,was
R251 T1118 T1117 acomp sufficient,was
R252 T1119 T1120 aux to,allow
R253 T1120 T1118 xcomp allow,sufficient
R254 T1121 T1120 dobj survival,allow
R255 T1122 T1109 punct ", ",was
R256 T1123 T1109 cc but,was
R257 T1124 T1109 conj was,was
R258 T1125 T1124 acomp insufficient,was
R259 T1126 T1127 aux to,circulating
R260 T1127 T1125 xcomp circulating,insufficient
R262 T1129 T1130 amod branched,chain
R263 T1130 T1132 compound chain,acids
R265 T1132 T1134 compound acids,levels
R267 T1134 T1127 dobj levels,circulating
R268 T1135 T1134 punct ", ",levels
R269 T1136 T1137 dep which,were
R270 T1137 T1134 relcl were,levels
R271 T1138 T1137 acomp intermediate,were
R272 T1139 T1137 prep between,were
R273 T1140 T1139 pobj wildtype,between
R274 T1141 T1140 cc and,wildtype
R275 T1142 T1143 det the,model
R276 T1143 T1140 conj model,wildtype
R280 T1147 T1109 punct .,was
R158 T1017 T1016 compound E2,gene
R159 T1018 T1016 compound subunit,gene
R163 T1022 T1021 punct -,chain
R165 T1024 T1025 compound keto,acid
R166 T1025 T1023 compound acid,dehydrogenase
R171 T1030 T1031 compound gene,knockout
R172 T1031 T1029 compound knockout,model
R173 T1032 T1029 compound mouse,model
R180 T1040 T1039 amod homozygous,mice
R181 T1041 T1039 compound knockout,mice
R184 T1045 T1044 punct -,chain
R186 T1047 T1048 compound keto,acid
R187 T1048 T1046 compound acid,dehydrogenase
R197 T1058 T1057 nummod 3,increase
R198 T1059 T1058 punct -,3
R199 T1060 T1058 amod fold,3
R203 T1064 T1065 amod branched,chain
R206 T1067 T1063 compound amino,acids
R210 T1072 T1071 amod metabolic,derangements
R220 T1085 T1084 amod human,cDNA
R221 T1086 T1084 compound E2,cDNA
R228 T1093 T1092 compound E2,animals
R229 T1094 T1092 compound knockout,animals
R238 T1104 T1103 punct -,chain
R240 T1106 T1107 compound keto,acid
R241 T1107 T1105 compound acid,dehydrogenase
R245 T1112 T1111 punct –,6
R261 T1128 T1127 aux normalize,circulating
R264 T1131 T1130 punct -,chain
R266 T1133 T1132 compound amino,acids
R277 T1144 T1143 amod classic,model
R278 T1145 T1143 compound MSUD,model
R279 T1146 T1143 compound mouse,model

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T801 26-36 PR_EXT:000006300 denotes E2 subunit
T802 37-41 SO_EXT:0000704 denotes gene
T803 60-69 CHEBI:25754 denotes keto acid
T804 98-102 SO_EXT:0000704 denotes gene
T805 112-117 NCBITaxon:10088 denotes mouse
T806 165-169 NCBITaxon:10088 denotes mice
T807 192-201 CHEBI:25754 denotes keto acid
T808 226-228 PR_EXT:000006300 denotes E2
T809 288-314 CHEBI:22918 denotes branched-chain amino acids
T810 303-314 CHEBI_SO_EXT:amino_acid denotes amino acids
T811 322-331 GO:0008152 denotes metabolic
T812 357-365 PATO_UBERON_EXT:neonate_or_newborn denotes neonatal
T813 366-375 GO_EXT:fatality_or_lethality denotes lethality
T814 377-387 SO_EXT:transgenic_entity denotes Transgenic
T815 388-398 GO:0010467 denotes expression
T816 404-409 NCBITaxon:9606 denotes human
T817 410-412 PR_EXT:000006300 denotes E2
T818 413-417 SO_EXT:cDNA denotes cDNA
T819 425-430 UBERON:0002107 denotes liver
T820 438-440 PR_EXT:000006300 denotes E2
T821 450-457 NCBITaxon:33208 denotes animals
T822 512-521 CHEBI:25754 denotes keto acid
T823 648-674 CHEBI:22918 denotes branched-chain amino acids
T824 663-674 CHEBI_SO_EXT:amino_acid denotes amino acids
T825 715-723 SO_EXT:wild_type_entity_or_quality denotes wildtype
T826 745-750 NCBITaxon:10088 denotes mouse

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T748 26-36 PR:000006300 denotes E2 subunit
T749 37-41 SO:0000704 denotes gene
T750 60-69 CHEBI:25754 denotes keto acid
T751 98-102 SO:0000704 denotes gene
T752 112-117 NCBITaxon:10088 denotes mouse
T753 165-169 NCBITaxon:10088 denotes mice
T754 192-201 CHEBI:25754 denotes keto acid
T755 226-228 PR:000006300 denotes E2
T756 288-314 CHEBI:22918 denotes branched-chain amino acids
T757 322-331 GO:0008152 denotes metabolic
T758 388-398 GO:0010467 denotes expression
T759 404-409 NCBITaxon:9606 denotes human
T760 410-412 PR:000006300 denotes E2
T761 425-430 UBERON:0002107 denotes liver
T762 438-440 PR:000006300 denotes E2
T763 450-457 NCBITaxon:33208 denotes animals
T764 512-521 CHEBI:25754 denotes keto acid
T765 648-674 CHEBI:22918 denotes branched-chain amino acids
T766 745-750 NCBITaxon:10088 denotes mouse