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PMC:1448208 / 8787-10266 JSONTXT

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Id Subject Object Predicate Lexical cue
T22055 10-12 NN denotes E2
T22056 33-43 NN denotes production
T22057 13-17 NN denotes gene
T22058 18-26 NN denotes knockout
T22059 27-32 NN denotes mouse
T22060 43-44 . denotes .
T22061 44-122 sentence denotes A, Gene targeting strategy used for targeting the E2 locus in mouse ES cells.
T22062 45-46 LS denotes A
T22063 63-71 NN denotes strategy
T22064 46-48 , denotes ,
T22065 48-52 NN denotes Gene
T22066 53-62 NN denotes targeting
T22067 72-76 VBN denotes used
T22068 77-80 IN denotes for
T22069 81-90 VBG denotes targeting
T22070 91-94 DT denotes the
T22071 98-103 NN denotes locus
T22072 95-97 NN denotes E2
T22073 104-106 IN denotes in
T22074 107-112 NN denotes mouse
T22075 116-121 NNS denotes cells
T22076 113-115 NN denotes ES
T22077 121-122 . denotes .
T22078 122-250 sentence denotes The targeting construct was designed to delete 1.67 kb of sequence between an EcoRV site in Exon 4 and a Smal site in intron 5.
T22079 123-126 DT denotes The
T22080 137-146 NN denotes construct
T22081 127-136 NN denotes targeting
T22082 151-159 VBN denotes designed
T22083 147-150 VBD denotes was
T22084 160-162 TO denotes to
T22085 163-169 VB denotes delete
T22086 170-174 CD denotes 1.67
T22087 175-177 NN denotes kb
T22088 178-180 IN denotes of
T22089 181-189 NN denotes sequence
T22090 190-197 IN denotes between
T22091 198-200 DT denotes an
T22092 207-211 NN denotes site
T22093 201-206 NN denotes EcoRV
T22094 212-214 IN denotes in
T22095 215-219 NN denotes Exon
T22096 220-221 CD denotes 4
T22097 222-225 CC denotes and
T22098 226-227 DT denotes a
T22099 233-237 NN denotes site
T22100 228-232 NN denotes Smal
T22101 238-240 IN denotes in
T22102 241-247 NN denotes intron
T22103 248-249 CD denotes 5
T22104 249-250 . denotes .
T22105 250-363 sentence denotes The wild type E2 gene contains an ~16 kb BglI restriction fragment that hybridizes to the Exon 6 specific probe.
T22106 251-254 DT denotes The
T22107 268-272 NN denotes gene
T22108 255-259 JJ denotes wild
T22109 260-264 NN denotes type
T22110 265-267 NN denotes E2
T22111 273-281 VBZ denotes contains
T22112 282-284 DT denotes an
T22113 309-317 NN denotes fragment
T22114 285-286 SYM denotes ~
T22115 286-288 CD denotes 16
T22116 289-291 NN denotes kb
T22117 292-296 NN denotes BglI
T22118 297-308 NN denotes restriction
T22119 318-322 WDT denotes that
T22120 323-333 VBZ denotes hybridizes
T22121 334-336 IN denotes to
T22122 337-340 DT denotes the
T22123 357-362 NN denotes probe
T22124 341-345 NN denotes Exon
T22125 348-356 JJ denotes specific
T22126 346-347 CD denotes 6
T22127 362-363 . denotes .
T22128 363-472 sentence denotes A correctly targeted E2 locus harbors an ~11 kb BglI restriction fragment that hybridizes to the same probe.
T22129 364-365 DT denotes A
T22130 388-393 NN denotes locus
T22131 366-375 RB denotes correctly
T22132 376-384 VBN denotes targeted
T22133 385-387 NN denotes E2
T22134 394-401 VBZ denotes harbors
T22135 402-404 DT denotes an
T22136 429-437 NN denotes fragment
T22137 405-406 SYM denotes ~
T22138 406-408 CD denotes 11
T22139 409-411 NN denotes kb
T22140 412-416 NN denotes BglI
T22141 417-428 NN denotes restriction
T22142 438-442 WDT denotes that
T22143 443-453 VBZ denotes hybridizes
T22144 454-456 IN denotes to
T22145 457-460 DT denotes the
T22146 466-471 NN denotes probe
T22147 461-465 JJ denotes same
T22148 471-472 . denotes .
T22149 472-599 sentence denotes Note that the probe will not detect random integration of the targeting vector because it is external to the targeting vector.
T22150 473-477 VB denotes Note
T22151 478-482 IN denotes that
T22152 502-508 VB denotes detect
T22153 483-486 DT denotes the
T22154 487-492 NN denotes probe
T22155 493-497 MD denotes will
T22156 498-501 RB denotes not
T22157 509-515 JJ denotes random
T22158 516-527 NN denotes integration
T22159 528-530 IN denotes of
T22160 531-534 DT denotes the
T22161 545-551 NN denotes vector
T22162 535-544 NN denotes targeting
T22163 552-559 IN denotes because
T22164 563-565 VBZ denotes is
T22165 560-562 PRP denotes it
T22166 566-574 JJ denotes external
T22167 575-577 IN denotes to
T22168 578-581 DT denotes the
T22169 592-598 NN denotes vector
T22170 582-591 NN denotes targeting
T22171 598-599 . denotes .
T22172 599-834 sentence denotes B, Southern blot analysis of Bgll digested genomic DNA derived from the parental wild type ES cell line (R1), a heterozygous targeted ES cell line (362), and from wild type (+/+), heterozygous (+/-) and homozygous knockout (-/-) mice.
T22173 600-601 LS denotes B
T22174 617-625 NN denotes analysis
T22175 601-603 , denotes ,
T22176 603-611 NNP denotes Southern
T22177 612-616 NN denotes blot
T22178 626-628 IN denotes of
T22179 629-633 NN denotes Bgll
T22180 634-642 VBN denotes digested
T22181 651-654 NN denotes DNA
T22182 643-650 JJ denotes genomic
T22183 655-662 VBN denotes derived
T22184 663-667 IN denotes from
T22185 668-671 DT denotes the
T22186 699-703 NN denotes line
T22187 672-680 JJ denotes parental
T22188 681-685 JJ denotes wild
T22189 686-690 NN denotes type
T22190 691-693 NN denotes ES
T22191 694-698 NN denotes cell
T22192 704-705 -LRB- denotes (
T22193 705-707 NN denotes R1
T22194 707-708 -RRB- denotes )
T22195 708-710 , denotes ,
T22196 710-711 DT denotes a
T22197 742-746 NN denotes line
T22198 712-724 JJ denotes heterozygous
T22199 725-733 VBN denotes targeted
T22200 734-736 NN denotes ES
T22201 737-741 NN denotes cell
T22202 747-748 -LRB- denotes (
T22203 748-751 CD denotes 362
T22204 751-752 -RRB- denotes )
T22205 752-754 , denotes ,
T22206 754-757 CC denotes and
T22207 758-762 IN denotes from
T22208 763-767 JJ denotes wild
T22209 768-772 NN denotes type
T22210 814-822 NN denotes knockout
T22211 773-774 -LRB- denotes (
T22212 776-777 SYM denotes +
T22213 774-775 SYM denotes +
T22214 775-776 HYPH denotes /
T22215 777-778 -RRB- denotes )
T22216 778-780 , denotes ,
T22217 780-792 JJ denotes heterozygous
T22218 793-794 -LRB- denotes (
T22219 796-797 SYM denotes -
T22220 794-795 SYM denotes +
T22221 795-796 HYPH denotes /
T22222 797-798 -RRB- denotes )
T22223 799-802 CC denotes and
T22224 803-813 JJ denotes homozygous
T22225 829-833 NNS denotes mice
T22226 823-824 -LRB- denotes (
T22227 826-827 SYM denotes -
T22228 824-825 SYM denotes -
T22229 825-826 HYPH denotes /
T22230 827-828 -RRB- denotes )
T22231 833-834 . denotes .
T22232 834-889 sentence denotes The blot was hybridized with an Exon 6 specific probe.
T22233 835-838 DT denotes The
T22234 839-843 NN denotes blot
T22235 848-858 VBN denotes hybridized
T22236 844-847 VBD denotes was
T22237 859-863 IN denotes with
T22238 864-866 DT denotes an
T22239 883-888 NN denotes probe
T22240 867-871 NN denotes Exon
T22241 874-882 JJ denotes specific
T22242 872-873 CD denotes 6
T22243 888-889 . denotes .
T22244 889-1021 sentence denotes C, Immunohistochemical analysis of fresh frozen liver sections from control (+/+) and E2 knockout (-/-) postnatal day 1 mouse pups.
T22245 890-891 LS denotes C
T22246 913-921 NN denotes analysis
T22247 891-893 , denotes ,
T22248 893-912 JJ denotes Immunohistochemical
T22249 922-924 IN denotes of
T22250 925-930 JJ denotes fresh
T22251 931-937 VBN denotes frozen
T22252 944-952 NNS denotes sections
T22253 938-943 NN denotes liver
T22254 953-957 IN denotes from
T22255 958-965 NN denotes control
T22256 979-987 NN denotes knockout
T22257 966-967 -LRB- denotes (
T22258 969-970 SYM denotes +
T22259 967-968 SYM denotes +
T22260 968-969 HYPH denotes /
T22261 970-971 -RRB- denotes )
T22262 972-975 CC denotes and
T22263 976-978 NN denotes E2
T22264 1016-1020 NNS denotes pups
T22265 988-989 -LRB- denotes (
T22266 991-992 SYM denotes -
T22267 989-990 SYM denotes -
T22268 990-991 HYPH denotes /
T22269 992-993 -RRB- denotes )
T22270 994-1003 JJ denotes postnatal
T22271 1004-1007 NN denotes day
T22272 1008-1009 CD denotes 1
T22273 1010-1015 NN denotes mouse
T22274 1020-1021 . denotes .
T22275 1021-1116 sentence denotes Sections were stained for E2 using an E2 specific antibody (green) and a nuclear stain (blue).
T22276 1022-1030 NNS denotes Sections
T22277 1036-1043 VBN denotes stained
T22278 1031-1035 VBD denotes were
T22279 1044-1047 IN denotes for
T22280 1048-1050 NN denotes E2
T22281 1051-1056 VBG denotes using
T22282 1057-1059 DT denotes an
T22283 1072-1080 NN denotes antibody
T22284 1060-1062 NN denotes E2
T22285 1063-1071 JJ denotes specific
T22286 1081-1082 -LRB- denotes (
T22287 1082-1087 JJ denotes green
T22288 1087-1088 -RRB- denotes )
T22289 1089-1092 CC denotes and
T22290 1093-1094 DT denotes a
T22291 1103-1108 NN denotes stain
T22292 1095-1102 JJ denotes nuclear
T22293 1109-1110 -LRB- denotes (
T22294 1110-1114 JJ denotes blue
T22295 1114-1115 -RRB- denotes )
T22296 1115-1116 . denotes .
T22297 1116-1205 sentence denotes Note the complete absence of E2 immunoreactivity in the section from the knockout mouse.
T22298 1117-1121 VB denotes Note
T22299 1122-1125 DT denotes the
T22300 1135-1142 NN denotes absence
T22301 1126-1134 JJ denotes complete
T22302 1143-1145 IN denotes of
T22303 1146-1148 NN denotes E2
T22304 1149-1165 NN denotes immunoreactivity
T22305 1166-1168 IN denotes in
T22306 1169-1172 DT denotes the
T22307 1173-1180 NN denotes section
T22308 1181-1185 IN denotes from
T22309 1186-1189 DT denotes the
T22310 1199-1204 NN denotes mouse
T22311 1190-1198 NN denotes knockout
T22312 1204-1205 . denotes .
T22313 1205-1319 sentence denotes D, Similar results were observed upon immunohistochemical analysis of primary mouse embryonic fibroblasts (MEFs).
T22314 1206-1207 LS denotes D
T22315 1230-1238 VBN denotes observed
T22316 1207-1209 , denotes ,
T22317 1209-1216 JJ denotes Similar
T22318 1217-1224 NNS denotes results
T22319 1225-1229 VBD denotes were
T22320 1239-1243 IN denotes upon
T22321 1244-1263 JJ denotes immunohistochemical
T22322 1264-1272 NN denotes analysis
T22323 1273-1275 IN denotes of
T22324 1276-1283 JJ denotes primary
T22325 1300-1311 NNS denotes fibroblasts
T22326 1284-1289 NN denotes mouse
T22327 1290-1299 JJ denotes embryonic
T22328 1312-1313 -LRB- denotes (
T22329 1313-1317 NNS denotes MEFs
T22330 1317-1318 -RRB- denotes )
T22331 1318-1319 . denotes .
T22332 1319-1479 sentence denotes Note that the readily detectable signal for E2 in the control cells was present in a pattern characteristic of mitochondria, the subcellular location of BCKDH.
T22333 1320-1324 VB denotes Note
T22334 1325-1329 IN denotes that
T22335 1388-1391 VBD denotes was
T22336 1330-1333 DT denotes the
T22337 1353-1359 NN denotes signal
T22338 1334-1341 RB denotes readily
T22339 1342-1352 JJ denotes detectable
T22340 1360-1363 IN denotes for
T22341 1364-1366 NN denotes E2
T22342 1367-1369 IN denotes in
T22343 1370-1373 DT denotes the
T22344 1382-1387 NNS denotes cells
T22345 1374-1381 NN denotes control
T22346 1392-1399 JJ denotes present
T22347 1400-1402 IN denotes in
T22348 1403-1404 DT denotes a
T22349 1405-1412 NN denotes pattern
T22350 1413-1427 JJ denotes characteristic
T22351 1428-1430 IN denotes of
T22352 1431-1443 NNS denotes mitochondria
T22353 1443-1445 , denotes ,
T22354 1445-1448 DT denotes the
T22355 1461-1469 NN denotes location
T22356 1449-1460 JJ denotes subcellular
T22357 1470-1472 IN denotes of
T22358 1473-1478 NN denotes BCKDH
T22359 1478-1479 . denotes .
R6272 T22055 T22056 compound E2,production
R6273 T22057 T22058 compound gene,knockout
R6274 T22058 T22056 compound knockout,production
R6275 T22059 T22056 compound mouse,production
R6276 T22060 T22056 punct .,production
R6277 T22062 T22063 meta A,strategy
R6278 T22064 T22063 punct ", ",strategy
R6279 T22065 T22066 compound Gene,targeting
R6280 T22066 T22063 compound targeting,strategy
R6281 T22067 T22063 acl used,strategy
R6282 T22068 T22067 prep for,used
R6283 T22069 T22068 pcomp targeting,for
R6284 T22070 T22071 det the,locus
R6285 T22071 T22069 dobj locus,targeting
R6286 T22072 T22071 compound E2,locus
R6287 T22073 T22067 prep in,used
R6288 T22074 T22075 compound mouse,cells
R6289 T22075 T22073 pobj cells,in
R6290 T22076 T22075 compound ES,cells
R6291 T22077 T22063 punct .,strategy
R6292 T22079 T22080 det The,construct
R6293 T22080 T22082 nsubjpass construct,designed
R6294 T22081 T22080 compound targeting,construct
R6295 T22083 T22082 auxpass was,designed
R6296 T22084 T22085 aux to,delete
R6297 T22085 T22082 advcl delete,designed
R6298 T22086 T22087 nummod 1.67,kb
R6299 T22087 T22085 dobj kb,delete
R6300 T22088 T22087 prep of,kb
R6301 T22089 T22088 pobj sequence,of
R6302 T22090 T22085 prep between,delete
R6303 T22091 T22092 det an,site
R6304 T22092 T22090 pobj site,between
R6305 T22093 T22092 compound EcoRV,site
R6306 T22094 T22092 prep in,site
R6307 T22095 T22094 pobj Exon,in
R6308 T22096 T22095 nummod 4,Exon
R6309 T22097 T22092 cc and,site
R6310 T22098 T22099 det a,site
R6311 T22099 T22092 conj site,site
R6312 T22100 T22099 compound Smal,site
R6313 T22101 T22099 prep in,site
R6314 T22102 T22101 pobj intron,in
R6315 T22103 T22102 nummod 5,intron
R6316 T22104 T22082 punct .,designed
R6317 T22106 T22107 det The,gene
R6318 T22107 T22111 nsubj gene,contains
R6319 T22108 T22109 amod wild,type
R6320 T22109 T22107 compound type,gene
R6321 T22110 T22107 compound E2,gene
R6322 T22112 T22113 det an,fragment
R6323 T22113 T22111 dobj fragment,contains
R6324 T22114 T22115 punct ~,16
R6325 T22115 T22116 nummod 16,kb
R6326 T22116 T22113 compound kb,fragment
R6327 T22117 T22113 compound BglI,fragment
R6328 T22118 T22113 compound restriction,fragment
R6329 T22119 T22120 dep that,hybridizes
R6330 T22120 T22113 relcl hybridizes,fragment
R6331 T22121 T22120 prep to,hybridizes
R6332 T22122 T22123 det the,probe
R6333 T22123 T22121 pobj probe,to
R6334 T22124 T22125 npadvmod Exon,specific
R6335 T22125 T22123 amod specific,probe
R6336 T22126 T22124 nummod 6,Exon
R6337 T22127 T22111 punct .,contains
R6338 T22129 T22130 det A,locus
R6339 T22130 T22134 nsubj locus,harbors
R6340 T22131 T22132 advmod correctly,targeted
R6341 T22132 T22130 amod targeted,locus
R6342 T22133 T22130 compound E2,locus
R6343 T22135 T22136 det an,fragment
R6344 T22136 T22134 dobj fragment,harbors
R6345 T22137 T22138 punct ~,11
R6346 T22138 T22139 nummod 11,kb
R6347 T22139 T22136 compound kb,fragment
R6348 T22140 T22136 compound BglI,fragment
R6349 T22141 T22136 compound restriction,fragment
R6350 T22142 T22143 dep that,hybridizes
R6351 T22143 T22136 relcl hybridizes,fragment
R6352 T22144 T22143 prep to,hybridizes
R6353 T22145 T22146 det the,probe
R6354 T22146 T22144 pobj probe,to
R6355 T22147 T22146 amod same,probe
R6356 T22148 T22134 punct .,harbors
R6357 T22151 T22152 mark that,detect
R6358 T22152 T22150 ccomp detect,Note
R6359 T22153 T22154 det the,probe
R6360 T22154 T22152 nsubj probe,detect
R6361 T22155 T22152 aux will,detect
R6362 T22156 T22152 neg not,detect
R6363 T22157 T22158 amod random,integration
R6364 T22158 T22152 dobj integration,detect
R6365 T22159 T22158 prep of,integration
R6366 T22160 T22161 det the,vector
R6367 T22161 T22159 pobj vector,of
R6368 T22162 T22161 compound targeting,vector
R6369 T22163 T22164 mark because,is
R6370 T22164 T22152 advcl is,detect
R6371 T22165 T22164 nsubj it,is
R6372 T22166 T22164 acomp external,is
R6373 T22167 T22166 prep to,external
R6374 T22168 T22169 det the,vector
R6375 T22169 T22167 pobj vector,to
R6376 T22170 T22169 compound targeting,vector
R6377 T22171 T22150 punct .,Note
R6378 T22173 T22174 meta B,analysis
R6379 T22175 T22174 punct ", ",analysis
R6380 T22176 T22177 compound Southern,blot
R6381 T22177 T22174 compound blot,analysis
R6382 T22178 T22174 prep of,analysis
R6383 T22179 T22180 npadvmod Bgll,digested
R6384 T22180 T22181 amod digested,DNA
R6385 T22181 T22178 pobj DNA,of
R6386 T22182 T22181 amod genomic,DNA
R6387 T22183 T22181 acl derived,DNA
R6388 T22184 T22183 prep from,derived
R6389 T22185 T22186 det the,line
R6390 T22186 T22184 pobj line,from
R6391 T22187 T22186 amod parental,line
R6392 T22188 T22189 amod wild,type
R6393 T22189 T22186 compound type,line
R6394 T22190 T22191 compound ES,cell
R6395 T22191 T22186 compound cell,line
R6396 T22192 T22193 punct (,R1
R6397 T22193 T22186 parataxis R1,line
R6398 T22194 T22193 punct ),R1
R6399 T22195 T22186 punct ", ",line
R6400 T22196 T22197 det a,line
R6401 T22197 T22186 appos line,line
R6402 T22198 T22197 amod heterozygous,line
R6403 T22199 T22197 amod targeted,line
R6404 T22200 T22201 compound ES,cell
R6405 T22201 T22197 compound cell,line
R6406 T22202 T22203 punct (,362
R6407 T22203 T22197 parataxis 362,line
R6408 T22204 T22203 punct ),362
R6409 T22205 T22184 punct ", ",from
R6410 T22206 T22184 cc and,from
R6411 T22207 T22184 conj from,from
R6412 T22208 T22209 amod wild,type
R6413 T22209 T22210 nmod type,knockout
R6414 T22210 T22225 nmod knockout,mice
R6415 T22211 T22212 punct (,+
R6416 T22212 T22209 punct +,type
R6417 T22213 T22212 punct +,+
R6418 T22214 T22212 punct /,+
R6419 T22215 T22212 punct ),+
R6420 T22216 T22209 punct ", ",type
R6421 T22217 T22209 conj heterozygous,type
R6422 T22218 T22219 punct (,-
R6423 T22219 T22217 punct -,heterozygous
R6424 T22220 T22219 punct +,-
R6425 T22221 T22219 punct /,-
R6426 T22222 T22219 punct ),-
R6427 T22223 T22217 cc and,heterozygous
R6428 T22224 T22217 conj homozygous,heterozygous
R6429 T22225 T22207 pobj mice,from
R6430 T22226 T22227 punct (,-
R6431 T22227 T22210 punct -,knockout
R6432 T22228 T22227 punct -,-
R6433 T22229 T22227 punct /,-
R6434 T22230 T22227 punct ),-
R6435 T22231 T22174 punct .,analysis
R6436 T22233 T22234 det The,blot
R6437 T22234 T22235 nsubjpass blot,hybridized
R6438 T22236 T22235 auxpass was,hybridized
R6439 T22237 T22235 prep with,hybridized
R6440 T22238 T22239 det an,probe
R6441 T22239 T22237 pobj probe,with
R6442 T22240 T22241 npadvmod Exon,specific
R6443 T22241 T22239 amod specific,probe
R6444 T22242 T22240 nummod 6,Exon
R6445 T22243 T22235 punct .,hybridized
R6446 T22245 T22246 meta C,analysis
R6447 T22247 T22246 punct ", ",analysis
R6448 T22248 T22246 amod Immunohistochemical,analysis
R6449 T22249 T22246 prep of,analysis
R6450 T22250 T22251 amod fresh,frozen
R6451 T22251 T22252 amod frozen,sections
R6452 T22252 T22249 pobj sections,of
R6453 T22253 T22252 compound liver,sections
R6454 T22254 T22252 prep from,sections
R6455 T22255 T22256 nmod control,knockout
R6456 T22256 T22264 nmod knockout,pups
R6457 T22257 T22258 punct (,+
R6458 T22258 T22255 punct +,control
R6459 T22259 T22258 punct +,+
R6460 T22260 T22258 punct /,+
R6461 T22261 T22258 punct ),+
R6462 T22262 T22255 cc and,control
R6463 T22263 T22255 conj E2,control
R6464 T22264 T22254 pobj pups,from
R6465 T22265 T22266 punct (,-
R6466 T22266 T22256 punct -,knockout
R6467 T22267 T22266 punct -,-
R6468 T22268 T22266 punct /,-
R6469 T22269 T22266 punct ),-
R6470 T22270 T22271 amod postnatal,day
R6471 T22271 T22264 nmod day,pups
R6472 T22272 T22271 nummod 1,day
R6473 T22273 T22264 compound mouse,pups
R6474 T22274 T22246 punct .,analysis
R6475 T22276 T22277 nsubjpass Sections,stained
R6476 T22278 T22277 auxpass were,stained
R6477 T22279 T22277 prep for,stained
R6478 T22280 T22279 pobj E2,for
R6479 T22281 T22277 advcl using,stained
R6480 T22282 T22283 det an,antibody
R6481 T22283 T22281 dobj antibody,using
R6482 T22284 T22285 npadvmod E2,specific
R6483 T22285 T22283 amod specific,antibody
R6484 T22286 T22287 punct (,green
R6485 T22287 T22283 parataxis green,antibody
R6486 T22288 T22287 punct ),green
R6487 T22289 T22283 cc and,antibody
R6488 T22290 T22291 det a,stain
R6489 T22291 T22283 conj stain,antibody
R6490 T22292 T22291 amod nuclear,stain
R6491 T22293 T22294 punct (,blue
R6492 T22294 T22291 parataxis blue,stain
R6493 T22295 T22294 punct ),blue
R6494 T22296 T22277 punct .,stained
R6495 T22299 T22300 det the,absence
R6496 T22300 T22298 dobj absence,Note
R6497 T22301 T22300 amod complete,absence
R6498 T22302 T22300 prep of,absence
R6499 T22303 T22304 compound E2,immunoreactivity
R6500 T22304 T22302 pobj immunoreactivity,of
R6501 T22305 T22298 prep in,Note
R6502 T22306 T22307 det the,section
R6503 T22307 T22305 pobj section,in
R6504 T22308 T22307 prep from,section
R6505 T22309 T22310 det the,mouse
R6506 T22310 T22308 pobj mouse,from
R6507 T22311 T22310 compound knockout,mouse
R6508 T22312 T22298 punct .,Note
R6509 T22314 T22315 meta D,observed
R6510 T22316 T22315 punct ", ",observed
R6511 T22317 T22318 amod Similar,results
R6512 T22318 T22315 nsubjpass results,observed
R6513 T22319 T22315 auxpass were,observed
R6514 T22320 T22315 prep upon,observed
R6515 T22321 T22322 amod immunohistochemical,analysis
R6516 T22322 T22320 pobj analysis,upon
R6517 T22323 T22322 prep of,analysis
R6518 T22324 T22325 amod primary,fibroblasts
R6519 T22325 T22323 pobj fibroblasts,of
R6520 T22326 T22325 nmod mouse,fibroblasts
R6521 T22327 T22325 amod embryonic,fibroblasts
R6522 T22328 T22325 punct (,fibroblasts
R6523 T22329 T22325 appos MEFs,fibroblasts
R6524 T22330 T22315 punct ),observed
R6525 T22331 T22315 punct .,observed
R6526 T22334 T22335 mark that,was
R6527 T22335 T22333 ccomp was,Note
R6528 T22336 T22337 det the,signal
R6529 T22337 T22335 nsubj signal,was
R6530 T22338 T22339 advmod readily,detectable
R6531 T22339 T22337 amod detectable,signal
R6532 T22340 T22337 prep for,signal
R6533 T22341 T22340 pobj E2,for
R6534 T22342 T22337 prep in,signal
R6535 T22343 T22344 det the,cells
R6536 T22344 T22342 pobj cells,in
R6537 T22345 T22344 compound control,cells
R6538 T22346 T22335 acomp present,was
R6539 T22347 T22346 prep in,present
R6540 T22348 T22349 det a,pattern
R6541 T22349 T22347 pobj pattern,in
R6542 T22350 T22349 amod characteristic,pattern
R6543 T22351 T22350 prep of,characteristic
R6544 T22352 T22351 pobj mitochondria,of
R6545 T22353 T22352 punct ", ",mitochondria
R6546 T22354 T22355 det the,location
R6547 T22355 T22352 appos location,mitochondria
R6548 T22356 T22355 amod subcellular,location
R6549 T22357 T22355 prep of,location
R6550 T22358 T22357 pobj BCKDH,of
R6551 T22359 T22333 punct .,Note

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21984 10-12 PR_EXT:000006300 denotes E2
T21985 13-17 SO_EXT:0000704 denotes gene
T21986 27-32 NCBITaxon:10088 denotes mouse
T21987 48-52 SO_EXT:0000704 denotes Gene
T21988 95-97 PR_EXT:000006300 denotes E2
T21989 107-112 NCBITaxon:10088 denotes mouse
T21990 113-121 CL:0002322 denotes ES cells
T21991 116-121 CL_GO_EXT:cell denotes cells
T21992 137-146 SO_EXT:engineered_biological_sequence denotes construct
T21993 163-169 SO_EXT:sequence_deletion_process denotes delete
T21994 176-177 CHEBI_SO_EXT:base denotes b
T21995 181-189 SO_EXT:biological_sequence denotes sequence
T21996 207-219 SO_EXT:0000852 denotes site in Exon
T21997 241-247 SO_EXT:0000188 denotes intron
T21998 255-264 SO_EXT:wild_type_entity_or_quality denotes wild type
T21999 265-267 PR_EXT:000006300 denotes E2
T22000 268-272 SO_EXT:0000704 denotes gene
T22001 290-291 CHEBI_SO_EXT:base denotes b
T22002 297-317 SO_EXT:0000412 denotes restriction fragment
T22003 323-333 GO:0097617 denotes hybridizes
T22004 341-345 SO_EXT:0000147 denotes Exon
T22005 357-362 CHEBI_SO_EXT:molecular_probe denotes probe
T22006 385-387 PR_EXT:000006300 denotes E2
T22007 410-411 CHEBI_SO_EXT:base denotes b
T22008 417-437 SO_EXT:0000412 denotes restriction fragment
T22009 443-453 GO:0097617 denotes hybridizes
T22010 466-471 CHEBI_SO_EXT:molecular_probe denotes probe
T22011 487-492 CHEBI_SO_EXT:molecular_probe denotes probe
T22012 535-551 SO_EXT:0001644 denotes targeting vector
T22013 582-598 SO_EXT:0001644 denotes targeting vector
T22014 643-654 SO_EXT:genomic_DNA denotes genomic DNA
T22015 651-654 CHEBI_SO_EXT:DNA denotes DNA
T22016 681-690 SO_EXT:wild_type_entity_or_quality denotes wild type
T22017 691-698 CL:0002322 denotes ES cell
T22018 694-698 CL_GO_EXT:cell denotes cell
T22019 734-741 CL:0002322 denotes ES cell
T22020 737-741 CL_GO_EXT:cell denotes cell
T22021 763-772 SO_EXT:wild_type_entity_or_quality denotes wild type
T22022 774-775 SO_EXT:normal_or_wild_type_or_present denotes +
T22023 776-777 SO_EXT:normal_or_wild_type_or_present denotes +
T22024 794-795 SO_EXT:normal_or_wild_type_or_present denotes +
T22025 796-797 SO_EXT:sequence_nullness_or_absence denotes -
T22026 824-825 SO_EXT:sequence_nullness_or_absence denotes -
T22027 826-827 SO_EXT:sequence_nullness_or_absence denotes -
T22028 829-833 NCBITaxon:10088 denotes mice
T22029 848-858 GO:0097617 denotes hybridized
T22030 867-871 SO_EXT:0000147 denotes Exon
T22031 883-888 CHEBI_SO_EXT:molecular_probe denotes probe
T22032 938-943 UBERON:0002107 denotes liver
T22033 967-968 SO_EXT:normal_or_wild_type_or_present denotes +
T22034 969-970 SO_EXT:normal_or_wild_type_or_present denotes +
T22035 976-978 PR_EXT:000006300 denotes E2
T22036 989-990 SO_EXT:sequence_nullness_or_absence denotes -
T22037 991-992 SO_EXT:sequence_nullness_or_absence denotes -
T22038 998-1003 GO:0007567 denotes natal
T22039 1010-1015 NCBITaxon:10088 denotes mouse
T22040 1016-1020 NCBITaxon_UBERON_EXT:pup denotes pups
T22041 1048-1050 PR_EXT:000006300 denotes E2
T22042 1060-1062 PR_EXT:000006300 denotes E2
T22043 1072-1080 GO:0042571 denotes antibody
T22044 1095-1102 GO:0005634 denotes nuclear
T22045 1146-1148 PR_EXT:000006300 denotes E2
T22046 1199-1204 NCBITaxon:10088 denotes mouse
T22047 1284-1289 NCBITaxon:10088 denotes mouse
T22048 1290-1299 UBERON:0000922 denotes embryonic
T22049 1300-1311 CL:0000057 denotes fibroblasts
T22050 1364-1366 PR_EXT:000006300 denotes E2
T22051 1382-1387 CL_GO_EXT:cell denotes cells
T22052 1431-1443 GO:0005739 denotes mitochondria
T22053 1449-1460 GO_UBERON_EXT:cellular_component_or_cell_part denotes subcellular
T22054 1452-1460 CL_GO_EXT:cell denotes cellular

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T21944 10-12 PR:000006300 denotes E2
T21945 13-17 SO:0000704 denotes gene
T21946 27-32 NCBITaxon:10088 denotes mouse
T21947 48-52 SO:0000704 denotes Gene
T21948 95-97 PR:000006300 denotes E2
T21949 107-112 NCBITaxon:10088 denotes mouse
T21950 113-121 CL:0002322 denotes ES cells
T21951 207-219 SO:0000852 denotes site in Exon
T21952 241-247 SO:0000188 denotes intron
T21953 265-267 PR:000006300 denotes E2
T21954 268-272 SO:0000704 denotes gene
T21955 297-317 SO:0000412 denotes restriction fragment
T21956 323-333 GO:0097617 denotes hybridizes
T21957 341-345 SO:0000147 denotes Exon
T21958 385-387 PR:000006300 denotes E2
T21959 417-437 SO:0000412 denotes restriction fragment
T21960 443-453 GO:0097617 denotes hybridizes
T21961 535-551 SO:0001644 denotes targeting vector
T21962 582-598 SO:0001644 denotes targeting vector
T21963 643-650 SO:0001026 denotes genomic
T21964 691-698 CL:0002322 denotes ES cell
T21965 734-741 CL:0002322 denotes ES cell
T21966 829-833 NCBITaxon:10088 denotes mice
T21967 848-858 GO:0097617 denotes hybridized
T21968 867-871 SO:0000147 denotes Exon
T21969 938-943 UBERON:0002107 denotes liver
T21970 976-978 PR:000006300 denotes E2
T21971 998-1003 GO:0007567 denotes natal
T21972 1010-1015 NCBITaxon:10088 denotes mouse
T21973 1048-1050 PR:000006300 denotes E2
T21974 1060-1062 PR:000006300 denotes E2
T21975 1072-1080 GO:0042571 denotes antibody
T21976 1095-1102 GO:0005634 denotes nuclear
T21977 1146-1148 PR:000006300 denotes E2
T21978 1199-1204 NCBITaxon:10088 denotes mouse
T21979 1284-1289 NCBITaxon:10088 denotes mouse
T21980 1290-1299 UBERON:0000922 denotes embryonic
T21981 1300-1311 CL:0000057 denotes fibroblasts
T21982 1364-1366 PR:000006300 denotes E2
T21983 1431-1443 GO:0005739 denotes mitochondria