| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T843 |
9-16 |
NN |
denotes |
disease |
| T848 |
3-8 |
NN |
denotes |
urine |
| T849 |
16-17 |
sentence |
denotes |
|
| T850 |
27-37 |
sentence |
denotes |
Background |
| T851 |
27-37 |
NN |
denotes |
Background |
| T852 |
37-169 |
sentence |
denotes |
Maple Syrup Urine Disease (MSUD) is an inborn error of metabolism caused by a deficiency of branched-chain keto acid dehydrogenase. |
| T853 |
38-43 |
NN |
denotes |
Maple |
| T854 |
44-49 |
NN |
denotes |
Syrup |
| T855 |
56-63 |
NN |
denotes |
Disease |
| T856 |
50-55 |
NN |
denotes |
Urine |
| T857 |
71-73 |
VBZ |
denotes |
is |
| T858 |
64-65 |
-LRB- |
denotes |
( |
| T859 |
65-69 |
NN |
denotes |
MSUD |
| T860 |
69-70 |
-RRB- |
denotes |
) |
| T861 |
74-76 |
DT |
denotes |
an |
| T862 |
84-89 |
NN |
denotes |
error |
| T863 |
77-83 |
JJ |
denotes |
inborn |
| T864 |
90-92 |
IN |
denotes |
of |
| T865 |
93-103 |
NN |
denotes |
metabolism |
| T866 |
104-110 |
VBN |
denotes |
caused |
| T867 |
111-113 |
IN |
denotes |
by |
| T868 |
114-115 |
DT |
denotes |
a |
| T869 |
116-126 |
NN |
denotes |
deficiency |
| T870 |
127-129 |
IN |
denotes |
of |
| T871 |
130-138 |
VBN |
denotes |
branched |
| T872 |
139-144 |
NN |
denotes |
chain |
| T873 |
138-139 |
HYPH |
denotes |
- |
| T874 |
155-168 |
NN |
denotes |
dehydrogenase |
| T875 |
145-149 |
NN |
denotes |
keto |
| T876 |
150-154 |
NN |
denotes |
acid |
| T877 |
168-169 |
. |
denotes |
. |
| T878 |
169-252 |
sentence |
denotes |
MSUD has several clinical phenotypes depending on the degree of enzyme deficiency. |
| T879 |
170-174 |
NN |
denotes |
MSUD |
| T880 |
175-178 |
VBZ |
denotes |
has |
| T881 |
179-186 |
JJ |
denotes |
several |
| T882 |
196-206 |
NNS |
denotes |
phenotypes |
| T883 |
187-195 |
JJ |
denotes |
clinical |
| T884 |
207-216 |
VBG |
denotes |
depending |
| T885 |
217-219 |
IN |
denotes |
on |
| T886 |
220-223 |
DT |
denotes |
the |
| T887 |
224-230 |
NN |
denotes |
degree |
| T888 |
231-233 |
IN |
denotes |
of |
| T889 |
234-240 |
NN |
denotes |
enzyme |
| T890 |
241-251 |
NN |
denotes |
deficiency |
| T891 |
251-252 |
. |
denotes |
. |
| T892 |
252-343 |
sentence |
denotes |
Current treatments are not satisfactory and require new approaches to combat this disease. |
| T893 |
253-260 |
JJ |
denotes |
Current |
| T894 |
261-271 |
NNS |
denotes |
treatments |
| T895 |
272-275 |
VBP |
denotes |
are |
| T896 |
276-279 |
RB |
denotes |
not |
| T897 |
280-292 |
JJ |
denotes |
satisfactory |
| T898 |
293-296 |
CC |
denotes |
and |
| T899 |
297-304 |
VBP |
denotes |
require |
| T900 |
305-308 |
JJ |
denotes |
new |
| T901 |
309-319 |
NNS |
denotes |
approaches |
| T902 |
320-322 |
TO |
denotes |
to |
| T903 |
323-329 |
VB |
denotes |
combat |
| T904 |
330-334 |
DT |
denotes |
this |
| T905 |
335-342 |
NN |
denotes |
disease |
| T906 |
342-343 |
. |
denotes |
. |
| T907 |
343-433 |
sentence |
denotes |
A major hurdle in developing new treatments has been the lack of a suitable animal model. |
| T908 |
344-345 |
DT |
denotes |
A |
| T909 |
352-358 |
NN |
denotes |
hurdle |
| T910 |
346-351 |
JJ |
denotes |
major |
| T911 |
392-396 |
VBN |
denotes |
been |
| T912 |
359-361 |
IN |
denotes |
in |
| T913 |
362-372 |
VBG |
denotes |
developing |
| T914 |
373-376 |
JJ |
denotes |
new |
| T915 |
377-387 |
NNS |
denotes |
treatments |
| T916 |
388-391 |
VBZ |
denotes |
has |
| T917 |
397-400 |
DT |
denotes |
the |
| T918 |
401-405 |
NN |
denotes |
lack |
| T919 |
406-408 |
IN |
denotes |
of |
| T920 |
409-410 |
DT |
denotes |
a |
| T921 |
427-432 |
NN |
denotes |
model |
| T922 |
411-419 |
JJ |
denotes |
suitable |
| T923 |
420-426 |
NN |
denotes |
animal |
| T924 |
432-433 |
. |
denotes |
. |
| T925 |
433-442 |
sentence |
denotes |
Methods |
| T926 |
435-442 |
NNS |
denotes |
Methods |
| T928 |
443-445 |
TO |
denotes |
To |
| T929 |
446-452 |
VB |
denotes |
create |
| T930 |
488-492 |
VBD |
denotes |
used |
| T931 |
453-454 |
DT |
denotes |
a |
| T932 |
462-467 |
NN |
denotes |
model |
| T933 |
455-461 |
JJ |
denotes |
murine |
| T934 |
468-470 |
IN |
denotes |
of |
| T935 |
471-478 |
JJ |
denotes |
classic |
| T936 |
479-483 |
NN |
denotes |
MSUD |
| T937 |
483-485 |
, |
denotes |
, |
| T938 |
485-487 |
PRP |
denotes |
we |
| T939 |
493-497 |
NN |
denotes |
gene |
| T940 |
498-507 |
NN |
denotes |
targeting |
| T941 |
508-511 |
CC |
denotes |
and |
| T942 |
512-521 |
JJ |
denotes |
embryonic |
| T943 |
527-531 |
NN |
denotes |
cell |
| T944 |
522-526 |
NN |
denotes |
stem |
| T945 |
532-544 |
NNS |
denotes |
technologies |
| T946 |
545-547 |
TO |
denotes |
to |
| T947 |
548-554 |
VB |
denotes |
create |
| T948 |
555-556 |
DT |
denotes |
a |
| T949 |
563-567 |
NN |
denotes |
line |
| T950 |
557-562 |
NN |
denotes |
mouse |
| T951 |
568-572 |
WDT |
denotes |
that |
| T952 |
573-579 |
VBD |
denotes |
lacked |
| T953 |
580-581 |
DT |
denotes |
a |
| T954 |
604-608 |
NN |
denotes |
gene |
| T955 |
582-592 |
JJ |
denotes |
functional |
| T956 |
593-595 |
NN |
denotes |
E2 |
| T957 |
596-603 |
NN |
denotes |
subunit |
| T958 |
609-611 |
IN |
denotes |
of |
| T959 |
612-620 |
VBN |
denotes |
branched |
| T961 |
620-621 |
HYPH |
denotes |
- |
| R13 |
T853 |
T854 |
compound |
Maple,Syrup |
| R14 |
T854 |
T855 |
compound |
Syrup,Disease |
| R15 |
T855 |
T857 |
nsubj |
Disease,is |
| R17 |
T858 |
T855 |
punct |
(,Disease |
| R18 |
T859 |
T855 |
appos |
MSUD,Disease |
| R19 |
T860 |
T857 |
punct |
),is |
| R20 |
T861 |
T862 |
det |
an,error |
| R21 |
T862 |
T857 |
attr |
error,is |
| R23 |
T864 |
T862 |
prep |
of,error |
| R24 |
T865 |
T864 |
pobj |
metabolism,of |
| R25 |
T866 |
T862 |
acl |
caused,error |
| R26 |
T867 |
T866 |
agent |
by,caused |
| R27 |
T868 |
T869 |
det |
a,deficiency |
| R28 |
T869 |
T867 |
pobj |
deficiency,by |
| R29 |
T870 |
T869 |
prep |
of,deficiency |
| R30 |
T871 |
T872 |
amod |
branched,chain |
| R31 |
T872 |
T874 |
compound |
chain,dehydrogenase |
| R33 |
T874 |
T870 |
pobj |
dehydrogenase,of |
| R36 |
T877 |
T857 |
punct |
.,is |
| R37 |
T879 |
T880 |
nsubj |
MSUD,has |
| R38 |
T881 |
T882 |
amod |
several,phenotypes |
| R39 |
T882 |
T880 |
dobj |
phenotypes,has |
| R41 |
T884 |
T880 |
prep |
depending,has |
| R42 |
T885 |
T884 |
prep |
on,depending |
| R43 |
T886 |
T887 |
det |
the,degree |
| R44 |
T887 |
T885 |
pobj |
degree,on |
| R45 |
T888 |
T887 |
prep |
of,degree |
| R46 |
T889 |
T890 |
compound |
enzyme,deficiency |
| R47 |
T890 |
T888 |
pobj |
deficiency,of |
| R48 |
T891 |
T880 |
punct |
.,has |
| R49 |
T893 |
T894 |
amod |
Current,treatments |
| R50 |
T894 |
T895 |
nsubj |
treatments,are |
| R51 |
T896 |
T895 |
neg |
not,are |
| R52 |
T897 |
T895 |
acomp |
satisfactory,are |
| R53 |
T898 |
T895 |
cc |
and,are |
| R54 |
T899 |
T895 |
conj |
require,are |
| R55 |
T900 |
T901 |
amod |
new,approaches |
| R56 |
T901 |
T899 |
dobj |
approaches,require |
| R57 |
T902 |
T903 |
aux |
to,combat |
| R58 |
T903 |
T899 |
advcl |
combat,require |
| R59 |
T904 |
T905 |
det |
this,disease |
| R60 |
T905 |
T903 |
dobj |
disease,combat |
| R61 |
T906 |
T895 |
punct |
.,are |
| R62 |
T908 |
T909 |
det |
A,hurdle |
| R63 |
T909 |
T911 |
nsubj |
hurdle,been |
| R65 |
T912 |
T909 |
prep |
in,hurdle |
| R66 |
T913 |
T912 |
pcomp |
developing,in |
| R67 |
T914 |
T915 |
amod |
new,treatments |
| R68 |
T915 |
T913 |
dobj |
treatments,developing |
| R69 |
T916 |
T911 |
aux |
has,been |
| R70 |
T917 |
T918 |
det |
the,lack |
| R71 |
T918 |
T911 |
attr |
lack,been |
| R72 |
T919 |
T918 |
prep |
of,lack |
| R73 |
T920 |
T921 |
det |
a,model |
| R74 |
T921 |
T919 |
pobj |
model,of |
| R77 |
T924 |
T911 |
punct |
.,been |
| R78 |
T928 |
T929 |
aux |
To,create |
| R79 |
T929 |
T930 |
advcl |
create,used |
| R80 |
T931 |
T932 |
det |
a,model |
| R81 |
T932 |
T929 |
dobj |
model,create |
| R83 |
T934 |
T932 |
prep |
of,model |
| R84 |
T935 |
T936 |
amod |
classic,MSUD |
| R85 |
T936 |
T934 |
pobj |
MSUD,of |
| R86 |
T937 |
T930 |
punct |
", ",used |
| R87 |
T938 |
T930 |
nsubj |
we,used |
| R88 |
T939 |
T940 |
compound |
gene,targeting |
| R89 |
T940 |
T930 |
dobj |
targeting,used |
| R90 |
T941 |
T940 |
cc |
and,targeting |
| R91 |
T942 |
T943 |
amod |
embryonic,cell |
| R92 |
T943 |
T945 |
compound |
cell,technologies |
| R94 |
T945 |
T940 |
conj |
technologies,targeting |
| R95 |
T946 |
T947 |
aux |
to,create |
| R96 |
T947 |
T930 |
advcl |
create,used |
| R97 |
T948 |
T949 |
det |
a,line |
| R98 |
T949 |
T947 |
dobj |
line,create |
| R100 |
T951 |
T952 |
dep |
that,lacked |
| R101 |
T952 |
T949 |
relcl |
lacked,line |
| R102 |
T953 |
T954 |
det |
a,gene |
| R103 |
T954 |
T952 |
dobj |
gene,lacked |
| R107 |
T958 |
T954 |
prep |
of,gene |
| R12 |
T848 |
T843 |
compound |
urine,disease |
| R16 |
T856 |
T855 |
compound |
Urine,Disease |
| R22 |
T863 |
T862 |
amod |
inborn,error |
| R32 |
T873 |
T872 |
punct |
-,chain |
| R34 |
T875 |
T876 |
compound |
keto,acid |
| R35 |
T876 |
T874 |
compound |
acid,dehydrogenase |
| R40 |
T883 |
T882 |
amod |
clinical,phenotypes |
| R64 |
T910 |
T909 |
amod |
major,hurdle |
| R75 |
T922 |
T921 |
amod |
suitable,model |
| R76 |
T923 |
T921 |
compound |
animal,model |
| R82 |
T933 |
T932 |
amod |
murine,model |
| R93 |
T944 |
T943 |
compound |
stem,cell |
| R99 |
T950 |
T949 |
compound |
mouse,line |
| R104 |
T955 |
T954 |
amod |
functional,gene |
| R105 |
T956 |
T954 |
compound |
E2,gene |
| R106 |
T957 |
T954 |
compound |
subunit,gene |