PMC:1448208 / 39441-39826 JSONTXT

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summary, this report describes the development and characterization of genetically engineered mouse models of classic as well as intermediate MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T21290","span":{"begin":367,"end":376},"obj":"GO:0008152"},{"id":"T21289","span":{"begin":321,"end":329},"obj":"CL_GO_EXT:cell"},{"id":"T21288","span":{"begin":312,"end":316},"obj":"SO_EXT:0000704"},{"id":"T21287","span":{"begin":168,"end":175},"obj":"NCBITaxon:33208"},{"id":"T21286","span":{"begin":108,"end":113},"obj":"NCBITaxon:10088"},{"id":"T21285","span":{"begin":85,"end":96},"obj":"SO_EXT:0000704"}],"text":"Conclusion\nIn summary, this report describes the development and characterization of genetically engineered mouse models of classic as well as intermediate MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T21284","span":{"begin":367,"end":376},"obj":"GO:0008152"},{"id":"T21283","span":{"begin":312,"end":316},"obj":"SO:0000704"},{"id":"T21282","span":{"begin":168,"end":175},"obj":"NCBITaxon:33208"},{"id":"T21281","span":{"begin":108,"end":113},"obj":"NCBITaxon:10088"},{"id":"T21280","span":{"begin":85,"end":96},"obj":"SO:0000704"}],"text":"Conclusion\nIn summary, this report describes the development and characterization of genetically engineered mouse models of classic as well as intermediate MSUD. These animals provide useful models to further characterize the pathogenesis of MSUD, as well as models to test novel therapeutic strategies, such as gene and cellular therapies, to treat this devastating metabolic disease."}