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PMC:1448208 / 37392-39439 JSONTXT

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Id Subject Object Predicate Lexical cue
T21121 1762-1766 NN denotes MSUD
T21120 1749-1761 JJ denotes intermediate
T21119 1767-1772 NN denotes model
T21118 1745-1748 DT denotes the
T21117 1743-1745 , denotes ,
T21112 1734-1736 CD denotes 36
T21111 1733-1734 , denotes ,
T21110 1731-1733 CD denotes 35
T21109 1740-1742 CD denotes 46
T21108 1730-1731 -LRB- denotes [
T21107 1720-1729 NNS denotes complexes
T21106 1708-1719 NN denotes multienzyme
T21105 1705-1707 IN denotes of
T21104 1696-1704 NN denotes analysis
T21103 1685-1695 JJ denotes structural
T21102 1682-1684 IN denotes in
T21101 1673-1681 NN denotes interest
T21100 1666-1672 JJ denotes recent
T21099 1663-1665 IN denotes of
T21098 1777-1784 VB denotes provide
T21097 1655-1662 IN denotes Because
T21096 1654-1839 sentence denotes Because of recent interest in structural analysis of multienzyme complexes [35,36,45,46], the intermediate MSUD model may provide a valuable resource for studies of structural biology.
T21095 1653-1654 . denotes .
T21094 1641-1646 JJ denotes whole
T21093 1647-1653 NN denotes animal
T21092 1637-1640 DT denotes the
T21091 1634-1636 IN denotes of
T21090 1628-1633 NN denotes level
T21089 1624-1627 DT denotes the
T21088 1621-1623 IN denotes at
T21087 1609-1613 NN denotes acid
T21086 1603-1608 NN denotes amino
T21085 1614-1620 NNS denotes levels
T21084 1597-1602 NN denotes blood
T21083 1593-1596 CC denotes and
T21082 1584-1592 NN denotes activity
T21081 1578-1583 NN denotes BCKDH
T21080 1575-1577 IN denotes to
T21079 1567-1574 NN denotes respect
T21078 1562-1566 IN denotes with
T21077 1554-1561 NN denotes thiamin
T21076 1551-1553 IN denotes of
T21075 1544-1550 NN denotes effect
T21074 1540-1543 DT denotes the
T21073 1535-1539 VB denotes test
T21072 1532-1534 TO denotes to
T21071 1526-1531 NN denotes model
T21070 1524-1525 DT denotes a
T21069 1504-1508 NN denotes MSUD
T21068 1491-1503 JJ denotes intermediate
T21067 1509-1514 NN denotes mouse
T21066 1487-1490 PRP$ denotes our
T21065 1485-1487 , denotes ,
T21064 1471-1476 JJR denotes newer
T21063 1477-1485 NNS denotes findings
T21062 1465-1470 DT denotes these
T21061 1462-1464 IN denotes of
T21060 1456-1461 NN denotes light
T21059 1515-1523 VBZ denotes provides
T21058 1453-1455 IN denotes In
T21057 1452-1654 sentence denotes In light of these newer findings, our intermediate MSUD mouse provides a model to test the effect of thiamin with respect to BCKDH activity and blood amino acid levels at the level of the whole animal.
T21056 1451-1452 . denotes .
T21055 1450-1451 -RRB- denotes ]
T21054 1447-1448 , denotes ,
T21053 1445-1447 CD denotes 45
T21052 1448-1450 CD denotes 46
T21051 1444-1445 -LRB- denotes [
T21050 1426-1436 VBG denotes expressing
T21049 1423-1425 NN denotes E2
T21048 1437-1443 NN denotes allele
T21047 1413-1418 RBS denotes least
T21046 1419-1422 CD denotes one
T21045 1410-1412 RB denotes at
T21044 1407-1409 IN denotes of
T21043 1398-1406 NN denotes presence
T21042 1394-1397 DT denotes the
T21041 1389-1393 IN denotes upon
T21040 1379-1388 JJ denotes dependent
T21039 1354-1355 HYPH denotes -
T21038 1355-1365 JJ denotes responsive
T21037 1347-1354 NN denotes thiamin
T21036 1366-1375 NN denotes phenotype
T21035 1343-1346 DT denotes the
T21034 1376-1378 VBZ denotes is
T21033 1338-1342 IN denotes that
T21032 1323-1327 VBP denotes have
T21031 1317-1322 NNS denotes cells
T21030 1312-1316 NN denotes MSUD
T21029 1307-1311 IN denotes with
T21028 1328-1337 VBN denotes suggested
T21027 1291-1298 NN denotes culture
T21026 1286-1290 NN denotes cell
T21025 1299-1306 NNS denotes studies
T21024 1279-1285 JJ denotes Recent
T21023 1278-1452 sentence denotes Recent cell culture studies with MSUD cells have suggested that the thiamin-responsive phenotype is dependent upon the presence of at least one E2 expressing allele [45,46].
T21022 1277-1278 . denotes .
T21021 1276-1277 -RRB- denotes ]
T21020 1275-1276 CD denotes 1
T21019 1274-1275 -LRB- denotes [
T21018 1266-1273 NN denotes success
T21017 1258-1265 JJ denotes limited
T21016 1245-1248 VBZ denotes has
T21015 1239-1244 NNS denotes doses
T21014 1231-1238 NN denotes thiamin
T21013 1228-1230 IN denotes of
T21012 1217-1221 JJ denotes wide
T21011 1222-1227 NN denotes range
T21010 1215-1216 DT denotes a
T21009 1210-1214 IN denotes with
T21008 1249-1257 VBN denotes produced
T21007 1200-1209 NN denotes treatment
T21006 1196-1199 CC denotes and
T21005 1182-1195 JJ denotes heterogeneous
T21004 1170-1178 NNS denotes patients
T21003 1164-1169 DT denotes these
T21002 1161-1163 IN denotes of
T21001 1179-1181 VBZ denotes is
T21000 1151-1160 NN denotes phenotype
T20999 1147-1150 DT denotes The
T20998 1146-1278 sentence denotes The phenotype of these patients is heterogeneous and treatment with a wide range of thiamin doses has produced limited success [1].
T20997 1145-1146 . denotes .
T20996 1144-1145 -RRB- denotes ]
T20995 1143-1144 CD denotes 1
T20994 1142-1143 -LRB- denotes [
T20993 1127-1131 VBN denotes been
T20992 1123-1126 VBZ denotes has
T20991 1118-1122 NN denotes MSUD
T20990 1115-1117 IN denotes of
T20989 1132-1141 VBN denotes described
T20988 1098-1099 HYPH denotes -
T20987 1099-1109 JJ denotes responsive
T20986 1091-1098 NN denotes thiamin
T20985 1110-1114 NN denotes form
T20984 1089-1090 DT denotes A
T20983 1088-1146 sentence denotes A thiamin-responsive form of MSUD has been described [1].
T20982 1087-1088 . denotes .
T20981 1080-1087 NN denotes thiamin
T20980 1077-1079 IN denotes of
T20979 1070-1076 NN denotes effect
T20978 1066-1069 DT denotes the
T20977 1061-1065 VB denotes test
T20976 1058-1060 TO denotes to
T20975 1050-1057 NNS denotes studies
T20974 1046-1049 IN denotes for
T20973 1039-1045 JJ denotes useful
T20972 1031-1035 RB denotes also
T20971 1027-1030 MD denotes may
T20970 1016-1020 NN denotes MSUD
T20969 1003-1015 JJ denotes intermediate
T20968 1021-1026 NN denotes model
T20967 999-1002 DT denotes the
T20966 997-999 , denotes ,
T20965 1036-1038 VB denotes be
T20964 985-997 RB denotes Additionally
T20963 984-1088 sentence denotes Additionally, the intermediate MSUD model may also be useful for studies to test the effect of thiamin.
T20962 983-984 . denotes .
T20961 977-983 NN denotes tissue
T20960 969-976 NN denotes autopsy
T20959 966-968 IN denotes on
T20958 956-960 MD denotes must
T20957 961-965 VB denotes rely
T20956 950-955 RB denotes often
T20955 946-949 CC denotes and
T20954 944-946 , denotes ,
T20953 929-936 JJ denotes ethical
T20952 937-944 NNS denotes reasons
T20951 921-928 JJ denotes obvious
T20950 917-920 IN denotes for
T20949 908-916 NNS denotes patients
T20948 902-907 JJ denotes human
T20947 899-901 IN denotes in
T20946 896-898 VB denotes do
T20945 893-895 TO denotes to
T20944 881-882 HYPH denotes /
T20943 882-892 JJ denotes impossible
T20942 872-881 JJ denotes difficult
T20941 867-871 RB denotes very
T20940 863-866 VBP denotes are
T20939 855-862 NNS denotes studies
T20938 850-854 JJ denotes Such
T20937 849-984 sentence denotes Such studies are very difficult/impossible to do in human patients for obvious ethical reasons, and often must rely on autopsy tissue.
T20936 848-849 . denotes .
T20935 841-848 NN denotes disease
T20934 837-840 DT denotes the
T20933 834-836 IN denotes of
T20932 804-820 JJ denotes pathophysiologic
T20931 793-803 VBG denotes underlying
T20930 821-833 NNS denotes consequences
T20929 789-792 DT denotes the
T20928 775-788 VBG denotes investigating
T20927 771-774 IN denotes for
T20926 764-770 JJ denotes useful
T20925 759-763 RB denotes very
T20924 751-755 RB denotes also
T20923 744-750 MD denotes should
T20922 737-743 NNS denotes models
T20921 731-736 DT denotes these
T20920 729-731 , denotes ,
T20919 719-729 NNS denotes treatments
T20918 711-718 JJ denotes various
T20917 703-710 VBG denotes testing
T20916 700-702 IN denotes to
T20915 691-699 NN denotes addition
T20914 756-758 VB denotes be
T20913 688-690 IN denotes In
T20912 687-849 sentence denotes In addition to testing various treatments, these models should also be very useful for investigating the underlying pathophysiologic consequences of the disease.
T20911 686-687 . denotes .
T20910 680-686 NNS denotes humans
T20909 677-679 IN denotes in
T20908 669-676 NNS denotes studies
T20907 665-668 IN denotes for
T20906 661-664 NN denotes way
T20905 657-660 DT denotes the
T20904 652-656 VB denotes pave
T20903 646-651 MD denotes could
T20902 642-645 CC denotes and
T20901 619-630 JJ denotes therapeutic
T20900 631-641 NNS denotes approaches
T20899 614-618 JJ denotes such
T20898 606-613 VB denotes advance
T20897 603-605 TO denotes to
T20895 583-590 NNS denotes studies
T20894 576-582 NN denotes animal
T20893 571-575 IN denotes with
T20892 594-602 VBN denotes expected
T20891 563-570 NN denotes Success
T20890 562-687 sentence denotes Success with animal studies is expected to advance such therapeutic approaches and could pave the way for studies in humans.
T20889 561-562 . denotes .
T20888 555-561 NN denotes safety
T20887 549-550 HYPH denotes -
T20886 545-549 JJ denotes long
T20885 541-544 CC denotes and
T20884 539-540 HYPH denotes -
T20883 550-554 NN denotes term
T20882 534-539 JJ denotes short
T20881 529-533 RB denotes also
T20880 525-528 CC denotes but
T20879 523-525 , denotes ,
T20878 511-514 DT denotes the
T20877 506-510 RB denotes only
T20876 515-523 NN denotes efficacy
T20875 502-505 RB denotes not
T20874 489-501 VBG denotes establishing
T20873 486-488 IN denotes of
T20872 467-478 JJ denotes preliminary
T20871 479-485 NN denotes method
T20870 465-466 DT denotes a
T20869 442-447 NN denotes model
T20868 435-441 NN denotes animal
T20867 448-455 NNS denotes systems
T20866 423-434 JJ denotes appropriate
T20865 420-422 IN denotes on
T20864 410-419 NNS denotes therapies
T20863 399-403 NN denotes cell
T20862 395-398 CC denotes and
T20861 404-409 VBN denotes based
T20860 390-394 NN denotes gene
T20859 387-389 IN denotes of
T20858 456-464 VBZ denotes provides
T20857 379-386 NN denotes testing
T20856 375-378 DT denotes The
T20855 374-562 sentence denotes The testing of gene and cell based therapies on appropriate animal model systems provides a preliminary method of establishing not only the efficacy, but also short- and long-term safety.
T20854 373-374 . denotes .
T20853 366-373 NNS denotes studies
T20852 354-365 JJ denotes preclinical
T20851 350-353 IN denotes for
T20850 341-349 NNS denotes diseases
T20849 333-340 JJ denotes genetic
T20848 330-332 IN denotes of
T20847 323-329 NNS denotes models
T20846 316-322 NN denotes animal
T20845 313-315 IN denotes of
T20844 308-312 NN denotes need
T20843 299-307 JJ denotes critical
T20842 295-298 CC denotes and
T20841 284-294 NN denotes importance
T20840 280-283 DT denotes the
T20839 263-269 NNS denotes humans
T21116 1742-1743 -RRB- denotes ]
T21115 1739-1740 , denotes ,
T21114 1737-1739 CD denotes 45
T21113 1736-1737 , denotes ,
T20838 260-262 IN denotes in
T20837 252-259 NN denotes therapy
T20836 247-251 NN denotes gene
T20835 242-246 IN denotes with
T20834 233-241 NNS denotes problems
T20833 226-232 JJ denotes recent
T20832 224-226 , denotes ,
T20831 217-224 NN denotes therapy
T20830 212-216 NN denotes gene
T20829 209-211 IN denotes to
T20828 270-279 VBP denotes highlight
T20827 200-208 JJ denotes Relevant
T20826 199-374 sentence denotes Relevant to gene therapy, recent problems with gene therapy in humans highlight the importance and critical need of animal models of genetic diseases for preclinical studies.
T20825 198-199 . denotes .
T20824 197-198 -RRB- denotes )
T20823 196-197 -RRB- denotes ]
T20822 194-196 CD denotes 44
T20821 193-194 -LRB- denotes [
T20820 182-186 NN denotes stem
T20819 187-192 NNS denotes cells
T20818 172-181 JJ denotes embryonic
T20817 169-171 CC denotes or
T20816 167-168 -RRB- denotes ]
T20815 164-165 , denotes ,
T20814 162-164 CD denotes 42
T20813 165-167 CD denotes 43
T20812 161-162 -LRB- denotes [
T20811 147-149 , denotes ,
T20810 143-147 FW denotes e.g.
T20809 149-160 NNS denotes hepatocytes
T20808 142-143 -LRB- denotes (
T20807 132-141 NNS denotes therapies
T20806 121-125 NN denotes cell
T20805 117-120 CC denotes and
T20804 115-116 -RRB- denotes ]
T20803 113-115 CD denotes 41
T20802 112-113 SYM denotes -
T20801 110-112 CD denotes 38
T20800 109-110 -LRB- denotes [
T20799 126-131 VBN denotes based
T20798 104-108 NN denotes gene
T20797 101-103 IN denotes as
T20796 96-100 JJ denotes such
T20795 85-95 NNS denotes treatments
T20794 79-84 JJ denotes novel
T20793 74-78 VB denotes test
T20792 71-73 TO denotes to
T20791 55-60 NN denotes mouse
T20790 50-54 NN denotes MSUD
T20789 61-67 NNS denotes models
T20788 46-49 DT denotes the
T20787 43-45 IN denotes by
T20786 33-42 VBN denotes presented
T20785 68-70 VBZ denotes is
T20784 9-20 JJ denotes significant
T20783 4-8 RBS denotes most
T20782 21-32 NN denotes opportunity
T20781 0-3 DT denotes The
T20896 591-593 VBZ denotes is
T21164 2046-2047 . denotes .
T21163 2039-2046 NNS denotes enzymes
T21162 2026-2038 JJ denotes multisubunit
T21161 2023-2025 IN denotes in
T21160 2015-2022 NNS denotes defects
T21159 2012-2014 IN denotes to
T21158 2008-2011 IN denotes due
T21157 1984-1997 JJ denotes mitochondrial
T21156 1998-2007 NNS denotes disorders
T21155 1978-1983 JJ denotes other
T21154 1975-1977 IN denotes to
T21153 1962-1974 JJ denotes transferable
T21152 1958-1961 CC denotes and
T21151 1947-1957 JJ denotes applicable
T21150 1939-1943 RB denotes also
T21149 1934-1938 MD denotes will
T21148 1929-1933 RB denotes here
T21147 1919-1928 VBN denotes described
T21146 1907-1911 NN denotes MSUD
T21145 1912-1918 NNS denotes models
T21144 1903-1906 DT denotes the
T21143 1898-1902 IN denotes with
T21142 1890-1897 NNS denotes studies
T21141 1885-1889 IN denotes from
T21140 1878-1884 VBN denotes gained
T21139 1868-1877 NN denotes knowledge
T21138 1864-1867 CC denotes and
T21137 1852-1863 NN denotes information
T21136 1848-1851 DT denotes the
T21135 1846-1848 , denotes ,
T21134 1944-1946 VB denotes be
T21133 1840-1846 RB denotes Lastly
T21132 1839-2047 sentence denotes Lastly, the information and knowledge gained from studies with the MSUD models described here will also be applicable and transferable to other mitochondrial disorders due to defects in multisubunit enzymes.
T21131 1838-1839 . denotes .
T21130 1831-1838 NN denotes biology
T21129 1820-1830 JJ denotes structural
T21128 1817-1819 IN denotes of
T21127 1809-1816 NNS denotes studies
T21126 1805-1808 IN denotes for
T21125 1787-1795 JJ denotes valuable
T21124 1796-1804 NN denotes resource
T21123 1785-1786 DT denotes a
T21122 1773-1776 MD denotes may
R5755 T20790 T20789 compound MSUD,models
R5756 T20791 T20789 compound mouse,models
R5757 T20792 T20793 aux to,test
R5758 T20793 T20785 xcomp test,is
R5759 T20794 T20795 amod novel,treatments
R5760 T20795 T20793 dobj treatments,test
R5761 T20796 T20797 amod such,as
R5762 T20797 T20795 prep as,treatments
R5763 T20798 T20799 npadvmod gene,based
R5764 T20799 T20807 amod based,therapies
R5765 T20800 T20801 punct [,38
R5766 T20801 T20798 parataxis 38,gene
R5767 T20802 T20803 punct -,41
R5768 T20803 T20801 prep 41,38
R5769 T20804 T20801 punct ],38
R5770 T20805 T20798 cc and,gene
R5771 T20806 T20798 conj cell,gene
R5773 T20807 T20797 pobj therapies,as
R5776 T20808 T20809 punct (,hepatocytes
R5779 T20809 T20807 parataxis hepatocytes,therapies
R5783 T20810 T20809 advmod e.g.,hepatocytes
R5786 T20811 T20809 punct ", ",hepatocytes
R5788 T20812 T20813 punct [,43
R5791 T20813 T20809 parataxis 43,hepatocytes
R5796 T20814 T20813 nummod 42,43
R5803 T20815 T20813 punct ",",43
R5807 T20816 T20813 punct ],43
R5811 T20817 T20809 cc or,hepatocytes
R5815 T20818 T20819 amod embryonic,cells
R5817 T20819 T20809 conj cells,hepatocytes
R5822 T20820 T20819 compound stem,cells
R5825 T20821 T20822 punct [,44
R5829 T20822 T20819 parataxis 44,cells
R5833 T20823 T20822 punct ],44
R5837 T20824 T20809 punct ),hepatocytes
R5841 T20825 T20785 punct .,is
R5844 T20827 T20828 advcl Relevant,highlight
R5847 T20829 T20827 prep to,Relevant
R5855 T20830 T20831 compound gene,therapy
R5859 T20831 T20829 pobj therapy,to
R5863 T20832 T20828 punct ", ",highlight
R5865 T20833 T20834 amod recent,problems
R5869 T20834 T20828 nsubj problems,highlight
R5872 T20835 T20834 prep with,problems
R5876 T20836 T20837 compound gene,therapy
R5880 T20837 T20835 pobj therapy,with
R5884 T20838 T20834 prep in,problems
R5888 T20839 T20838 pobj humans,in
R5892 T20840 T20841 det the,importance
R5894 T20841 T20828 dobj importance,highlight
R5895 T20781 T20782 det The,opportunity
R5896 T20782 T20785 nsubj opportunity,is
R5897 T20783 T20784 advmod most,significant
R5898 T20784 T20782 amod significant,opportunity
R5899 T20842 T20841 cc and,importance
R5900 T20786 T20782 acl presented,opportunity
R5901 T20787 T20786 agent by,presented
R5902 T20788 T20789 det the,models
R5903 T20789 T20787 pobj models,by
R5904 T20843 T20844 amod critical,need
R5905 T20844 T20841 conj need,importance
R5906 T20845 T20841 prep of,importance
R5907 T20846 T20847 compound animal,models
R5908 T20847 T20845 pobj models,of
R5909 T20848 T20847 prep of,models
R5910 T20896 T20892 auxpass is,expected
R5911 T20897 T20898 aux to,advance
R5912 T20849 T20850 amod genetic,diseases
R5913 T20898 T20892 xcomp advance,expected
R5914 T20899 T20900 amod such,approaches
R5915 T20900 T20898 dobj approaches,advance
R5916 T20850 T20848 pobj diseases,of
R5917 T20901 T20900 amod therapeutic,approaches
R5918 T20902 T20892 cc and,expected
R5919 T20903 T20904 aux could,pave
R5920 T20904 T20892 conj pave,expected
R5921 T20851 T20841 prep for,importance
R5922 T20905 T20906 det the,way
R5923 T20906 T20904 dobj way,pave
R5924 T20852 T20853 amod preclinical,studies
R5925 T20907 T20904 prep for,pave
R5926 T20908 T20907 pobj studies,for
R5927 T20853 T20851 pobj studies,for
R5928 T20909 T20908 prep in,studies
R5929 T20910 T20909 pobj humans,in
R5930 T20911 T20892 punct .,expected
R5931 T20854 T20828 punct .,highlight
R5932 T20913 T20914 prep In,be
R5933 T20856 T20857 det The,testing
R5934 T20857 T20858 nsubj testing,provides
R5935 T20915 T20913 pobj addition,In
R5936 T20916 T20915 prep to,addition
R5937 T20859 T20857 prep of,testing
R5938 T20917 T20916 pcomp testing,to
R5939 T20918 T20919 amod various,treatments
R5940 T20919 T20917 dobj treatments,testing
R5941 T20920 T20914 punct ", ",be
R5942 T20860 T20861 npadvmod gene,based
R5943 T20921 T20922 det these,models
R5944 T20922 T20914 nsubj models,be
R5945 T20923 T20914 aux should,be
R5946 T20861 T20864 amod based,therapies
R5947 T20924 T20914 advmod also,be
R5948 T20925 T20926 advmod very,useful
R5949 T20862 T20860 cc and,gene
R5950 T20926 T20914 acomp useful,be
R5951 T20927 T20926 prep for,useful
R5952 T20863 T20860 conj cell,gene
R5953 T20928 T20927 pcomp investigating,for
R5954 T20929 T20930 det the,consequences
R5955 T20930 T20928 dobj consequences,investigating
R5956 T20931 T20930 amod underlying,consequences
R5957 T20932 T20930 amod pathophysiologic,consequences
R5958 T20933 T20930 prep of,consequences
R5959 T20864 T20859 pobj therapies,of
R5960 T20934 T20935 det the,disease
R5961 T20935 T20933 pobj disease,of
R5962 T20936 T20914 punct .,be
R5963 T20865 T20857 prep on,testing
R5964 T20938 T20939 amod Such,studies
R5965 T20939 T20940 nsubj studies,are
R5966 T20866 T20867 amod appropriate,systems
R5967 T20941 T20942 advmod very,difficult
R5968 T20942 T20943 amod difficult,impossible
R5969 T20867 T20865 pobj systems,on
R5970 T20943 T20940 acomp impossible,are
R5971 T20944 T20943 punct /,impossible
R5972 T20945 T20946 aux to,do
R5973 T20868 T20867 compound animal,systems
R5974 T20946 T20943 advcl do,impossible
R5975 T20947 T20946 prep in,do
R5976 T20948 T20949 amod human,patients
R5977 T20869 T20867 compound model,systems
R5978 T20949 T20947 pobj patients,in
R5979 T20950 T20946 prep for,do
R5980 T20951 T20952 amod obvious,reasons
R5981 T20870 T20871 det a,method
R5982 T20952 T20950 pobj reasons,for
R5983 T20953 T20952 amod ethical,reasons
R5984 T20954 T20940 punct ", ",are
R5985 T20871 T20858 dobj method,provides
R5986 T20955 T20940 cc and,are
R5987 T20956 T20957 advmod often,rely
R5988 T20957 T20940 conj rely,are
R5989 T20872 T20871 amod preliminary,method
R5990 T20958 T20957 aux must,rely
R5991 T20959 T20957 prep on,rely
R5992 T20960 T20961 compound autopsy,tissue
R5993 T20873 T20871 prep of,method
R5994 T20961 T20959 pobj tissue,on
R5995 T20962 T20940 punct .,are
R5996 T20874 T20873 pcomp establishing,of
R5997 T20964 T20965 advmod Additionally,be
R5998 T20875 T20876 preconj not,efficacy
R5999 T20966 T20965 punct ", ",be
R6000 T20967 T20968 det the,model
R6001 T20968 T20965 nsubj model,be
R6002 T20969 T20968 amod intermediate,model
R6003 T20876 T20874 dobj efficacy,establishing
R6004 T20970 T20968 compound MSUD,model
R6005 T20971 T20965 aux may,be
R6006 T20877 T20875 advmod only,not
R6007 T20972 T20965 advmod also,be
R6008 T20973 T20965 acomp useful,be
R6009 T20974 T20973 prep for,useful
R6010 T20975 T20974 pobj studies,for
R6011 T20976 T20977 aux to,test
R6012 T20977 T20975 advcl test,studies
R6013 T20878 T20876 det the,efficacy
R6014 T20978 T20979 det the,effect
R6015 T20979 T20977 dobj effect,test
R6016 T20980 T20979 prep of,effect
R6017 T20879 T20876 punct ", ",efficacy
R6018 T20981 T20980 pobj thiamin,of
R6019 T20982 T20965 punct .,be
R6020 T20880 T20876 cc but,efficacy
R6021 T20984 T20985 det A,form
R6022 T20881 T20880 advmod also,but
R6023 T20985 T20989 nsubjpass form,described
R6024 T20882 T20883 amod short,term
R6025 T20986 T20987 npadvmod thiamin,responsive
R6026 T20987 T20985 amod responsive,form
R6027 T20883 T20888 compound term,safety
R6028 T20988 T20987 punct -,responsive
R6029 T20990 T20985 prep of,form
R6030 T20884 T20882 punct -,short
R6031 T20991 T20990 pobj MSUD,of
R6032 T20992 T20989 aux has,described
R6033 T20885 T20882 cc and,short
R6034 T20993 T20989 auxpass been,described
R6035 T20994 T20995 punct [,1
R6036 T20886 T20882 conj long,short
R6037 T20995 T20989 parataxis 1,described
R6038 T20996 T20995 punct ],1
R6039 T20997 T20989 punct .,described
R6040 T20887 T20883 punct -,term
R6041 T20999 T21000 det The,phenotype
R6042 T21000 T21001 nsubj phenotype,is
R6043 T20888 T20876 conj safety,efficacy
R6044 T20889 T20858 punct .,provides
R6045 T20891 T20892 nsubjpass Success,expected
R6046 T20893 T20891 prep with,Success
R6047 T21002 T21000 prep of,phenotype
R6048 T21003 T21004 det these,patients
R6049 T20894 T20895 compound animal,studies
R6050 T21004 T21002 pobj patients,of
R6051 T20895 T20893 pobj studies,with
R6052 T21005 T21001 acomp heterogeneous,is
R6053 T21006 T21001 cc and,is
R6055 T21007 T21008 nsubj treatment,produced
R6056 T21008 T21001 conj produced,is
R6057 T21009 T21007 prep with,treatment
R6058 T21010 T21011 det a,range
R6059 T21011 T21009 pobj range,with
R6060 T21012 T21011 amod wide,range
R6061 T21013 T21011 prep of,range
R6062 T21014 T21015 compound thiamin,doses
R6064 T21015 T21013 pobj doses,of
R6065 T21016 T21008 aux has,produced
R6066 T21017 T21018 amod limited,success
R6067 T21018 T21008 dobj success,produced
R6069 T21019 T21020 punct [,1
R6070 T21020 T21008 parataxis 1,produced
R6072 T21021 T21020 punct ],1
R6073 T21022 T21008 punct .,produced
R6075 T21024 T21025 amod Recent,studies
R6076 T21025 T21028 nsubj studies,suggested
R6077 T21026 T21027 compound cell,culture
R6079 T21027 T21025 compound culture,studies
R6080 T21029 T21025 prep with,studies
R6082 T21030 T21031 compound MSUD,cells
R6083 T21031 T21029 pobj cells,with
R6084 T21032 T21028 aux have,suggested
R6086 T21033 T21034 mark that,is
R6087 T21034 T21028 ccomp is,suggested
R6089 T21035 T21036 det the,phenotype
R6090 T21036 T21034 nsubj phenotype,is
R6091 T21117 T21098 punct ", ",provide
R6092 T21037 T21038 npadvmod thiamin,responsive
R6093 T21038 T21036 amod responsive,phenotype
R6094 T21118 T21119 det the,model
R6095 T21039 T21038 punct -,responsive
R6096 T21040 T21034 acomp dependent,is
R6097 T21041 T21040 prep upon,dependent
R6098 T21119 T21098 nsubj model,provide
R6099 T21042 T21043 det the,presence
R6100 T21043 T21041 pobj presence,upon
R6101 T21044 T21043 prep of,presence
R6102 T21045 T21046 advmod at,one
R6103 T21120 T21119 amod intermediate,model
R6104 T21046 T21048 nummod one,allele
R6105 T21047 T21046 advmod least,one
R6106 T21048 T21044 pobj allele,of
R6107 T21121 T21119 compound MSUD,model
R6108 T21049 T21050 npadvmod E2,expressing
R6109 T21050 T21048 amod expressing,allele
R6110 T21051 T21052 punct [,46
R6111 T21052 T21028 parataxis 46,suggested
R6112 T21053 T21052 nummod 45,46
R6113 T21054 T21052 punct ",",46
R6114 T21055 T21052 punct ],46
R6115 T21122 T21098 aux may,provide
R6116 T21056 T21028 punct .,suggested
R6117 T21058 T21059 prep In,provides
R6118 T21123 T21124 det a,resource
R6119 T21060 T21058 pobj light,In
R6120 T21061 T21060 prep of,light
R6121 T21124 T21098 dobj resource,provide
R6122 T21062 T21063 det these,findings
R6123 T21063 T21061 pobj findings,of
R6124 T21064 T21063 amod newer,findings
R6125 T21125 T21124 amod valuable,resource
R6126 T21065 T21059 punct ", ",provides
R6127 T21066 T21067 poss our,mouse
R6128 T21126 T21124 prep for,resource
R6129 T21067 T21059 nsubj mouse,provides
R6130 T21068 T21067 amod intermediate,mouse
R6131 T21069 T21067 compound MSUD,mouse
R6132 T21127 T21126 pobj studies,for
R6133 T21070 T21071 det a,model
R6134 T21071 T21059 dobj model,provides
R6135 T21072 T21073 aux to,test
R6136 T21073 T21071 advcl test,model
R6137 T21128 T21127 prep of,studies
R6138 T21074 T21075 det the,effect
R6139 T21075 T21073 dobj effect,test
R6140 T21076 T21075 prep of,effect
R6141 T21129 T21130 amod structural,biology
R6142 T21077 T21076 pobj thiamin,of
R6143 T21130 T21128 pobj biology,of
R6144 T21078 T21073 prep with,test
R6145 T21079 T21078 pobj respect,with
R6146 T21080 T21079 prep to,respect
R6147 T21081 T21082 compound BCKDH,activity
R6148 T21131 T21098 punct .,provide
R6149 T21082 T21080 pobj activity,to
R6150 T21083 T21082 cc and,activity
R6151 T21084 T21085 compound blood,levels
R6152 T21133 T21134 advmod Lastly,be
R6153 T21085 T21082 conj levels,activity
R6154 T21086 T21087 compound amino,acid
R6155 T21087 T21085 compound acid,levels
R6156 T21088 T21073 prep at,test
R6157 T21135 T21134 punct ", ",be
R6158 T21089 T21090 det the,level
R6159 T21090 T21088 pobj level,at
R6160 T21136 T21137 det the,information
R6161 T21091 T21090 prep of,level
R6162 T21092 T21093 det the,animal
R6163 T21093 T21091 pobj animal,of
R6164 T21094 T21093 amod whole,animal
R6165 T21095 T21059 punct .,provides
R6166 T21137 T21134 nsubj information,be
R6167 T21097 T21098 prep Because,provide
R6168 T21138 T21137 cc and,information
R6169 T21099 T21097 pcomp of,Because
R6170 T21100 T21101 amod recent,interest
R6171 T21101 T21097 pobj interest,Because
R6172 T21139 T21137 conj knowledge,information
R6173 T21102 T21101 prep in,interest
R6174 T21103 T21104 amod structural,analysis
R6175 T21104 T21102 pobj analysis,in
R6176 T21140 T21137 acl gained,information
R6177 T21105 T21104 prep of,analysis
R6178 T21106 T21107 compound multienzyme,complexes
R6179 T21107 T21105 pobj complexes,of
R6180 T21141 T21140 prep from,gained
R6181 T21142 T21141 pobj studies,from
R6182 T21143 T21142 prep with,studies
R6183 T21144 T21145 det the,models
R6184 T21145 T21143 pobj models,with
R6185 T21146 T21145 compound MSUD,models
R6186 T21147 T21145 acl described,models
R6187 T21148 T21147 advmod here,described
R6188 T21149 T21134 aux will,be
R6189 T21150 T21134 advmod also,be
R6190 T21151 T21134 acomp applicable,be
R6191 T21152 T21151 cc and,applicable
R6192 T21153 T21151 conj transferable,applicable
R6193 T21154 T21153 prep to,transferable
R6194 T21155 T21156 amod other,disorders
R6195 T21156 T21154 pobj disorders,to
R6196 T21157 T21156 amod mitochondrial,disorders
R6197 T21158 T21134 prep due,be
R6198 T21159 T21158 pcomp to,due
R6199 T21160 T21158 pobj defects,due
R6200 T21161 T21160 prep in,defects
R6201 T21162 T21163 amod multisubunit,enzymes
R6202 T21163 T21161 pobj enzymes,in
R6203 T21164 T21134 punct .,be
R6054 T21108 T21109 punct [,46
R6063 T21109 T21097 parataxis 46,Because
R6068 T21110 T21109 nummod 35,46
R6071 T21111 T21109 punct ",",46
R6074 T21112 T21109 nummod 36,46
R6078 T21113 T21109 punct ",",46
R6081 T21114 T21109 nummod 45,46
R6085 T21115 T21109 punct ",",46
R6088 T21116 T21109 punct ],46

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19825 2039-2046 CHEBI_GO_SO_EXT:enzyme denotes enzymes
T19824 1984-1997 GO:0005739 denotes mitochondrial
T19823 1962-1974 GO_EXT:biological_movement_or_translocation_process denotes transferable
T19822 1831-1838 CHEBI_GO_EXT:biological_process_or_quality_or_role denotes biology
T19821 1720-1729 GO:0032991 denotes complexes
T19820 1713-1719 CHEBI_GO_SO_EXT:enzyme denotes enzyme
T19819 1647-1653 NCBITaxon:33208 denotes animal
T19818 1603-1613 CHEBI_SO_EXT:amino_acid denotes amino acid
T19817 1597-1602 UBERON:0000178 denotes blood
T19816 1554-1561 CHEBI:26948 denotes thiamin
T19815 1509-1514 NCBITaxon:10088 denotes mouse
T19814 1437-1443 SO_EXT:0001023 denotes allele
T19813 1426-1436 GO:0010467 denotes expressing
T19812 1423-1425 PR_EXT:000006300 denotes E2
T19811 1347-1354 CHEBI:26948 denotes thiamin
T19810 1317-1322 CL_GO_EXT:cell denotes cells
T19809 1286-1290 CL_GO_EXT:cell denotes cell
T19808 1231-1238 CHEBI:26948 denotes thiamin
T19807 1091-1098 CHEBI:26948 denotes thiamin
T19806 1080-1087 CHEBI:26948 denotes thiamin
T19805 977-983 UBERON:0000479 denotes tissue
T19804 902-907 NCBITaxon:9606 denotes human
T19803 680-686 NCBITaxon:9606 denotes humans
T19802 576-582 NCBITaxon:33208 denotes animal
T19801 435-441 NCBITaxon:33208 denotes animal
T19800 399-403 CL_GO_EXT:cell denotes cell
T19799 390-394 SO_EXT:0000704 denotes gene
T19798 333-340 SO_EXT:0000704 denotes genetic
T19797 316-322 NCBITaxon:33208 denotes animal
T19796 263-269 NCBITaxon:9606 denotes humans
T19795 247-251 SO_EXT:0000704 denotes gene
T19794 212-216 SO_EXT:0000704 denotes gene
T19793 187-192 CL_GO_EXT:cell denotes cells
T19792 172-192 CL:0002322 denotes embryonic stem cells
T19791 172-181 UBERON:0000922 denotes embryonic
T19790 149-160 CL:0000182 denotes hepatocytes
T19789 121-125 CL_GO_EXT:cell denotes cell
T19788 104-108 SO_EXT:0000704 denotes gene
T19787 55-60 NCBITaxon:10088 denotes mouse

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19647 1597-1602 UBERON:0000178 denotes blood
T19646 1554-1561 CHEBI:26948 denotes thiamin
T19645 1509-1514 NCBITaxon:10088 denotes mouse
T19644 1437-1443 SO:0001023 denotes allele
T19643 1426-1436 GO:0010467 denotes expressing
T19642 1423-1425 PR:000006300 denotes E2
T19641 1347-1354 CHEBI:26948 denotes thiamin
T19640 1231-1238 CHEBI:26948 denotes thiamin
T19639 1091-1098 CHEBI:26948 denotes thiamin
T19638 1080-1087 CHEBI:26948 denotes thiamin
T19637 977-983 UBERON:0000479 denotes tissue
T19636 902-907 NCBITaxon:9606 denotes human
T19635 680-686 NCBITaxon:9606 denotes humans
T19634 576-582 NCBITaxon:33208 denotes animal
T19633 435-441 NCBITaxon:33208 denotes animal
T19632 390-394 SO:0000704 denotes gene
T19631 333-340 SO:0000704 denotes genetic
T19630 316-322 NCBITaxon:33208 denotes animal
T19629 263-269 NCBITaxon:9606 denotes humans
T19628 247-251 SO:0000704 denotes gene
T19627 212-216 SO:0000704 denotes gene
T19626 172-192 CL:0002322 denotes embryonic stem cells
T19625 172-181 UBERON:0000922 denotes embryonic
T19624 149-160 CL:0000182 denotes hepatocytes
T19623 104-108 SO:0000704 denotes gene
T19622 55-60 NCBITaxon:10088 denotes mouse
T19650 1984-1997 GO:0005739 denotes mitochondrial
T19649 1720-1729 GO:0032991 denotes complexes
T19648 1647-1653 NCBITaxon:33208 denotes animal