Id |
Subject |
Object |
Predicate |
Lexical cue |
T20779 |
980-981 |
. |
denotes |
. |
T20778 |
970-975 |
JJ |
denotes |
human |
T20777 |
976-980 |
NN |
denotes |
MSUD |
T20776 |
961-969 |
VBG |
denotes |
modeling |
T20775 |
957-960 |
IN |
denotes |
for |
T20774 |
945-956 |
JJ |
denotes |
appropriate |
T20773 |
941-944 |
CC |
denotes |
and |
T20772 |
935-940 |
JJ |
denotes |
valid |
T20771 |
930-934 |
RBR |
denotes |
more |
T20770 |
919-925 |
NN |
denotes |
report |
T20769 |
914-918 |
DT |
denotes |
this |
T20768 |
911-913 |
IN |
denotes |
in |
T20767 |
901-910 |
VBN |
denotes |
described |
T20766 |
887-893 |
JJ |
denotes |
murine |
T20765 |
894-900 |
NNS |
denotes |
models |
T20764 |
883-886 |
DT |
denotes |
the |
T20763 |
881-883 |
, |
denotes |
, |
T20762 |
873-881 |
NN |
denotes |
contrast |
T20761 |
926-929 |
VBP |
denotes |
are |
T20760 |
870-872 |
IN |
denotes |
In |
T20759 |
869-981 |
sentence |
denotes |
In contrast, the murine models described in this report are more valid and appropriate for modeling human MSUD. |
T20758 |
868-869 |
. |
denotes |
. |
T20757 |
861-868 |
NN |
denotes |
utility |
T20756 |
853-860 |
JJ |
denotes |
limited |
T20755 |
850-852 |
IN |
denotes |
of |
T20754 |
845-849 |
RB |
denotes |
also |
T20753 |
836-841 |
NN |
denotes |
model |
T20752 |
831-835 |
DT |
denotes |
this |
T20751 |
829-831 |
, |
denotes |
, |
T20750 |
828-829 |
-RRB- |
denotes |
] |
T20749 |
827-828 |
CD |
denotes |
1 |
T20748 |
826-827 |
-LRB- |
denotes |
[ |
T20747 |
819-825 |
NNS |
denotes |
humans |
T20746 |
814-818 |
NN |
denotes |
MSUD |
T20745 |
810-813 |
CC |
denotes |
and |
T20744 |
800-803 |
NN |
denotes |
cow |
T20743 |
795-799 |
NN |
denotes |
MSUD |
T20742 |
804-809 |
NN |
denotes |
model |
T20741 |
791-794 |
DT |
denotes |
the |
T20740 |
783-790 |
IN |
denotes |
between |
T20739 |
771-782 |
NNS |
denotes |
differences |
T20738 |
768-770 |
IN |
denotes |
of |
T20737 |
756-767 |
NN |
denotes |
observation |
T20736 |
752-755 |
DT |
denotes |
the |
T20735 |
749-751 |
IN |
denotes |
to |
T20734 |
745-748 |
IN |
denotes |
due |
T20733 |
741-744 |
CC |
denotes |
and |
T20732 |
728-734 |
NN |
denotes |
animal |
T20731 |
722-727 |
JJ |
denotes |
large |
T20730 |
720-721 |
DT |
denotes |
a |
T20729 |
735-740 |
NN |
denotes |
model |
T20728 |
715-719 |
JJ |
denotes |
such |
T20727 |
712-714 |
IN |
denotes |
by |
T20726 |
704-711 |
VBN |
denotes |
imposed |
T20725 |
692-703 |
NNS |
denotes |
constraints |
T20724 |
682-691 |
JJ |
denotes |
practical |
T20723 |
679-681 |
IN |
denotes |
to |
T20722 |
675-678 |
IN |
denotes |
due |
T20721 |
673-675 |
, |
denotes |
, |
T20720 |
842-844 |
VBZ |
denotes |
is |
T20719 |
666-673 |
RB |
denotes |
However |
T20718 |
665-869 |
sentence |
denotes |
However, due to practical constraints imposed by such a large animal model and due to the observation of differences between the MSUD cow model and MSUD humans [1], this model is also of limited utility. |
T20717 |
664-665 |
. |
denotes |
. |
T20716 |
663-664 |
-RRB- |
denotes |
] |
T20715 |
661-663 |
CD |
denotes |
19 |
T20714 |
660-661 |
SYM |
denotes |
- |
T20713 |
658-660 |
CD |
denotes |
17 |
T20712 |
657-658 |
-LRB- |
denotes |
[ |
T20711 |
636-646 |
RB |
denotes |
previously |
T20710 |
631-635 |
VBN |
denotes |
been |
T20709 |
626-630 |
RB |
denotes |
also |
T20708 |
622-625 |
VBZ |
denotes |
has |
T20707 |
617-621 |
NN |
denotes |
MSUD |
T20706 |
614-616 |
IN |
denotes |
of |
T20705 |
604-607 |
NN |
denotes |
cow |
T20704 |
608-613 |
NN |
denotes |
model |
T20703 |
602-603 |
DT |
denotes |
a |
T20702 |
600-602 |
, |
denotes |
, |
T20701 |
589-594 |
NN |
denotes |
mouse |
T20700 |
595-600 |
NN |
denotes |
model |
T20699 |
584-588 |
DT |
denotes |
this |
T20698 |
581-583 |
IN |
denotes |
to |
T20697 |
572-580 |
NN |
denotes |
addition |
T20696 |
647-656 |
VBN |
denotes |
described |
T20695 |
569-571 |
IN |
denotes |
In |
T20694 |
568-665 |
sentence |
denotes |
In addition to this mouse model, a cow model of MSUD has also been previously described [17-19]. |
T20693 |
567-568 |
. |
denotes |
. |
T20692 |
557-567 |
NN |
denotes |
deficiency |
T20691 |
552-556 |
NN |
denotes |
BCAT |
T20690 |
549-551 |
IN |
denotes |
to |
T20689 |
541-548 |
NN |
denotes |
disease |
T20688 |
536-540 |
DT |
denotes |
this |
T20687 |
524-535 |
VBG |
denotes |
attributing |
T20686 |
509-513 |
VBN |
denotes |
been |
T20685 |
505-508 |
VBZ |
denotes |
has |
T20684 |
500-504 |
NN |
denotes |
MSUD |
T20683 |
497-499 |
IN |
denotes |
of |
T20682 |
492-496 |
NN |
denotes |
case |
T20681 |
489-491 |
DT |
denotes |
no |
T20680 |
487-489 |
, |
denotes |
, |
T20674 |
458-463 |
NN |
denotes |
BCKDH |
T20673 |
455-457 |
IN |
denotes |
of |
T20672 |
464-467 |
VBP |
denotes |
are |
T20671 |
448-454 |
NNS |
denotes |
levels |
T20670 |
444-447 |
DT |
denotes |
the |
T20669 |
440-443 |
CC |
denotes |
and |
T20668 |
434-439 |
NN |
denotes |
BCKDH |
T20667 |
431-433 |
IN |
denotes |
in |
T20666 |
427-430 |
RB |
denotes |
not |
T20665 |
415-423 |
NN |
denotes |
mutation |
T20664 |
411-414 |
DT |
denotes |
the |
T20663 |
424-426 |
VBZ |
denotes |
is |
T20662 |
403-410 |
IN |
denotes |
because |
T20661 |
398-402 |
NN |
denotes |
MSUD |
T20660 |
395-397 |
IN |
denotes |
of |
T20659 |
384-388 |
JJ |
denotes |
true |
T20658 |
389-394 |
NN |
denotes |
model |
T20657 |
382-383 |
DT |
denotes |
a |
T20656 |
378-381 |
RB |
denotes |
not |
T20655 |
372-374 |
PRP |
denotes |
it |
T20654 |
370-372 |
, |
denotes |
, |
T20653 |
353-364 |
JJ |
denotes |
interesting |
T20652 |
365-370 |
NN |
denotes |
model |
T20651 |
350-352 |
DT |
denotes |
an |
T20650 |
375-377 |
VBZ |
denotes |
is |
T20649 |
342-346 |
DT |
denotes |
this |
T20648 |
347-349 |
VBZ |
denotes |
is |
T20647 |
336-341 |
IN |
denotes |
While |
T20646 |
335-475 |
sentence |
denotes |
While this is an interesting model, it is not a true model of MSUD because the mutation is not in BCKDH and the levels of BCKDH are normal. |
T20645 |
334-335 |
. |
denotes |
. |
T20644 |
326-334 |
JJ |
denotes |
elevated |
T20643 |
317-325 |
RB |
denotes |
markedly |
T20642 |
300-304 |
NN |
denotes |
BCAA |
T20641 |
294-299 |
NN |
denotes |
blood |
T20640 |
305-311 |
NNS |
denotes |
levels |
T20639 |
290-293 |
DT |
denotes |
the |
T20638 |
283-289 |
IN |
denotes |
though |
T20637 |
312-316 |
VBD |
denotes |
were |
T20636 |
278-282 |
RB |
denotes |
even |
T20635 |
271-277 |
JJ |
denotes |
normal |
T20634 |
261-266 |
NN |
denotes |
mouse |
T20633 |
256-260 |
DT |
denotes |
this |
T20632 |
253-255 |
IN |
denotes |
of |
T20631 |
246-252 |
NN |
denotes |
muscle |
T20630 |
242-245 |
CC |
denotes |
and |
T20629 |
236-241 |
NN |
denotes |
liver |
T20628 |
232-235 |
DT |
denotes |
the |
T20627 |
229-231 |
IN |
denotes |
in |
T20626 |
267-270 |
VBD |
denotes |
was |
T20625 |
214-219 |
NN |
denotes |
BCKDH |
T20624 |
220-228 |
NN |
denotes |
activity |
T20623 |
210-213 |
DT |
denotes |
The |
T20622 |
209-335 |
sentence |
denotes |
The BCKDH activity in the liver and muscle of this mouse was normal even though the blood BCAA levels were markedly elevated. |
T20621 |
208-209 |
. |
denotes |
. |
T20620 |
207-208 |
-RRB- |
denotes |
] |
T20619 |
205-207 |
CD |
denotes |
20 |
T20618 |
204-205 |
-LRB- |
denotes |
[ |
T20617 |
194-198 |
NN |
denotes |
BCAT |
T20616 |
180-193 |
JJ |
denotes |
mitochondrial |
T20615 |
199-203 |
NN |
denotes |
gene |
T20614 |
176-179 |
DT |
denotes |
the |
T20613 |
165-175 |
VBG |
denotes |
disrupting |
T20612 |
162-164 |
IN |
denotes |
by |
T20611 |
143-153 |
RB |
denotes |
previously |
T20610 |
139-142 |
VBD |
denotes |
was |
T20609 |
134-138 |
NN |
denotes |
MSUD |
T20608 |
128-133 |
JJ |
denotes |
human |
T20607 |
117-127 |
VBG |
denotes |
resembling |
T20606 |
154-161 |
VBN |
denotes |
created |
T20605 |
107-110 |
NN |
denotes |
ENU |
T20604 |
111-116 |
NN |
denotes |
mouse |
T20603 |
104-106 |
DT |
denotes |
An |
T20602 |
103-209 |
sentence |
denotes |
An ENU mouse resembling human MSUD was previously created by disrupting the mitochondrial BCAT gene [20]. |
T20601 |
102-103 |
. |
denotes |
. |
T20600 |
86-95 |
VBN |
denotes |
described |
T20599 |
75-85 |
RB |
denotes |
previously |
T20598 |
96-102 |
NNS |
denotes |
models |
T20597 |
71-74 |
DT |
denotes |
the |
T20596 |
66-70 |
IN |
denotes |
over |
T20595 |
57-65 |
NNS |
denotes |
advances |
T20594 |
47-56 |
JJ |
denotes |
important |
T20593 |
29-42 |
NN |
denotes |
communication |
T20592 |
24-28 |
DT |
denotes |
this |
T20591 |
21-23 |
IN |
denotes |
in |
T20590 |
11-20 |
VBN |
denotes |
described |
T20589 |
43-46 |
VBP |
denotes |
are |
T20588 |
4-10 |
NNS |
denotes |
models |
T20587 |
0-3 |
DT |
denotes |
The |
T20679 |
514-523 |
VBN |
denotes |
described |
T20678 |
476-487 |
RB |
denotes |
Furthermore |
T20677 |
475-568 |
sentence |
denotes |
Furthermore, no case of MSUD has been described attributing this disease to BCAT deficiency. |
T20676 |
474-475 |
. |
denotes |
. |
T20675 |
468-474 |
JJ |
denotes |
normal |
R5667 |
T20587 |
T20588 |
det |
The,models |
R5668 |
T20588 |
T20589 |
nsubj |
models,are |
R5669 |
T20590 |
T20588 |
acl |
described,models |
R5670 |
T20591 |
T20590 |
prep |
in,described |
R5671 |
T20592 |
T20593 |
det |
this,communication |
R5672 |
T20593 |
T20591 |
pobj |
communication,in |
R5673 |
T20594 |
T20595 |
amod |
important,advances |
R5674 |
T20595 |
T20589 |
attr |
advances,are |
R5675 |
T20596 |
T20595 |
prep |
over,advances |
R5676 |
T20597 |
T20598 |
det |
the,models |
R5677 |
T20598 |
T20596 |
pobj |
models,over |
R5678 |
T20599 |
T20600 |
advmod |
previously,described |
R5679 |
T20600 |
T20598 |
amod |
described,models |
R5680 |
T20601 |
T20589 |
punct |
.,are |
R5681 |
T20603 |
T20604 |
det |
An,mouse |
R5682 |
T20604 |
T20606 |
nsubjpass |
mouse,created |
R5683 |
T20605 |
T20604 |
compound |
ENU,mouse |
R5684 |
T20607 |
T20604 |
acl |
resembling,mouse |
R5685 |
T20608 |
T20609 |
amod |
human,MSUD |
R5686 |
T20609 |
T20607 |
dobj |
MSUD,resembling |
R5687 |
T20610 |
T20606 |
auxpass |
was,created |
R5688 |
T20611 |
T20606 |
advmod |
previously,created |
R5689 |
T20612 |
T20606 |
prep |
by,created |
R5690 |
T20613 |
T20612 |
pcomp |
disrupting,by |
R5691 |
T20614 |
T20615 |
det |
the,gene |
R5692 |
T20615 |
T20613 |
dobj |
gene,disrupting |
R5693 |
T20616 |
T20615 |
amod |
mitochondrial,gene |
R5694 |
T20617 |
T20615 |
compound |
BCAT,gene |
R5695 |
T20618 |
T20619 |
punct |
[,20 |
R5696 |
T20619 |
T20606 |
parataxis |
20,created |
R5697 |
T20620 |
T20619 |
punct |
],20 |
R5698 |
T20621 |
T20606 |
punct |
.,created |
R5699 |
T20623 |
T20624 |
det |
The,activity |
R5700 |
T20624 |
T20626 |
nsubj |
activity,was |
R5701 |
T20625 |
T20624 |
compound |
BCKDH,activity |
R5702 |
T20627 |
T20624 |
prep |
in,activity |
R5703 |
T20628 |
T20629 |
det |
the,liver |
R5704 |
T20629 |
T20627 |
pobj |
liver,in |
R5705 |
T20630 |
T20629 |
cc |
and,liver |
R5706 |
T20631 |
T20629 |
conj |
muscle,liver |
R5707 |
T20632 |
T20629 |
prep |
of,liver |
R5708 |
T20633 |
T20634 |
det |
this,mouse |
R5709 |
T20634 |
T20632 |
pobj |
mouse,of |
R5710 |
T20635 |
T20626 |
acomp |
normal,was |
R5711 |
T20636 |
T20637 |
advmod |
even,were |
R5712 |
T20637 |
T20626 |
advcl |
were,was |
R5713 |
T20638 |
T20637 |
mark |
though,were |
R5714 |
T20639 |
T20640 |
det |
the,levels |
R5715 |
T20640 |
T20637 |
nsubj |
levels,were |
R5716 |
T20641 |
T20640 |
compound |
blood,levels |
R5717 |
T20642 |
T20640 |
compound |
BCAA,levels |
R5718 |
T20643 |
T20644 |
advmod |
markedly,elevated |
R5719 |
T20644 |
T20637 |
acomp |
elevated,were |
R5720 |
T20645 |
T20626 |
punct |
.,was |
R5721 |
T20647 |
T20648 |
mark |
While,is |
R5722 |
T20648 |
T20650 |
advcl |
is,is |
R5723 |
T20649 |
T20648 |
nsubj |
this,is |
R5724 |
T20651 |
T20652 |
det |
an,model |
R5725 |
T20652 |
T20648 |
attr |
model,is |
R5726 |
T20653 |
T20652 |
amod |
interesting,model |
R5727 |
T20654 |
T20650 |
punct |
", ",is |
R5728 |
T20655 |
T20650 |
nsubj |
it,is |
R5729 |
T20656 |
T20650 |
neg |
not,is |
R5730 |
T20657 |
T20658 |
det |
a,model |
R5731 |
T20658 |
T20650 |
attr |
model,is |
R5732 |
T20659 |
T20658 |
amod |
true,model |
R5733 |
T20660 |
T20658 |
prep |
of,model |
R5734 |
T20661 |
T20660 |
pobj |
MSUD,of |
R5735 |
T20662 |
T20663 |
mark |
because,is |
R5736 |
T20663 |
T20650 |
advcl |
is,is |
R5737 |
T20664 |
T20665 |
det |
the,mutation |
R5738 |
T20665 |
T20663 |
nsubj |
mutation,is |
R5739 |
T20666 |
T20663 |
neg |
not,is |
R5740 |
T20667 |
T20663 |
prep |
in,is |
R5741 |
T20668 |
T20667 |
pobj |
BCKDH,in |
R5742 |
T20669 |
T20663 |
cc |
and,is |
R5743 |
T20670 |
T20671 |
det |
the,levels |
R5744 |
T20671 |
T20672 |
nsubj |
levels,are |
R5745 |
T20672 |
T20663 |
conj |
are,is |
R5746 |
T20673 |
T20671 |
prep |
of,levels |
R5747 |
T20674 |
T20673 |
pobj |
BCKDH,of |
R5748 |
T20675 |
T20672 |
acomp |
normal,are |
R5749 |
T20676 |
T20650 |
punct |
.,is |
R5750 |
T20678 |
T20679 |
advmod |
Furthermore,described |
R5751 |
T20680 |
T20679 |
punct |
", ",described |
R5752 |
T20681 |
T20682 |
det |
no,case |
R5753 |
T20682 |
T20679 |
nsubjpass |
case,described |
R5754 |
T20683 |
T20682 |
prep |
of,case |
R5772 |
T20684 |
T20683 |
pobj |
MSUD,of |
R5774 |
T20685 |
T20679 |
aux |
has,described |
R5775 |
T20686 |
T20679 |
auxpass |
been,described |
R5777 |
T20687 |
T20679 |
advcl |
attributing,described |
R5778 |
T20688 |
T20689 |
det |
this,disease |
R5780 |
T20689 |
T20687 |
dobj |
disease,attributing |
R5781 |
T20690 |
T20687 |
prep |
to,attributing |
R5782 |
T20691 |
T20692 |
compound |
BCAT,deficiency |
R5784 |
T20692 |
T20690 |
pobj |
deficiency,to |
R5785 |
T20693 |
T20679 |
punct |
.,described |
R5787 |
T20695 |
T20696 |
prep |
In,described |
R5789 |
T20697 |
T20695 |
pobj |
addition,In |
R5790 |
T20698 |
T20697 |
prep |
to,addition |
R5792 |
T20699 |
T20700 |
det |
this,model |
R5793 |
T20700 |
T20698 |
pobj |
model,to |
R5794 |
T20701 |
T20700 |
compound |
mouse,model |
R5795 |
T20702 |
T20696 |
punct |
", ",described |
R5797 |
T20703 |
T20704 |
det |
a,model |
R5798 |
T20704 |
T20696 |
nsubjpass |
model,described |
R5799 |
T20705 |
T20704 |
compound |
cow,model |
R5800 |
T20706 |
T20704 |
prep |
of,model |
R5801 |
T20707 |
T20706 |
pobj |
MSUD,of |
R5802 |
T20708 |
T20696 |
aux |
has,described |
R5804 |
T20709 |
T20696 |
advmod |
also,described |
R5805 |
T20710 |
T20696 |
auxpass |
been,described |
R5806 |
T20711 |
T20696 |
advmod |
previously,described |
R5808 |
T20712 |
T20713 |
punct |
[,17 |
R5809 |
T20713 |
T20696 |
parataxis |
17,described |
R5810 |
T20714 |
T20715 |
punct |
-,19 |
R5812 |
T20715 |
T20713 |
prep |
19,17 |
R5813 |
T20716 |
T20713 |
punct |
],17 |
R5814 |
T20717 |
T20696 |
punct |
.,described |
R5816 |
T20719 |
T20720 |
advmod |
However,is |
R5818 |
T20721 |
T20720 |
punct |
", ",is |
R5819 |
T20722 |
T20720 |
prep |
due,is |
R5820 |
T20723 |
T20722 |
pcomp |
to,due |
R5821 |
T20724 |
T20725 |
amod |
practical,constraints |
R5823 |
T20725 |
T20722 |
pobj |
constraints,due |
R5824 |
T20726 |
T20725 |
acl |
imposed,constraints |
R5826 |
T20727 |
T20726 |
agent |
by,imposed |
R5827 |
T20728 |
T20729 |
amod |
such,model |
R5828 |
T20729 |
T20727 |
pobj |
model,by |
R5830 |
T20730 |
T20729 |
det |
a,model |
R5831 |
T20731 |
T20729 |
amod |
large,model |
R5832 |
T20732 |
T20729 |
compound |
animal,model |
R5834 |
T20733 |
T20722 |
cc |
and,due |
R5835 |
T20734 |
T20722 |
conj |
due,due |
R5836 |
T20735 |
T20734 |
pcomp |
to,due |
R5838 |
T20736 |
T20737 |
det |
the,observation |
R5839 |
T20737 |
T20734 |
pobj |
observation,due |
R5840 |
T20738 |
T20737 |
prep |
of,observation |
R5842 |
T20739 |
T20738 |
pobj |
differences,of |
R5843 |
T20740 |
T20739 |
prep |
between,differences |
R5845 |
T20741 |
T20742 |
det |
the,model |
R5846 |
T20742 |
T20740 |
pobj |
model,between |
R5848 |
T20743 |
T20742 |
compound |
MSUD,model |
R5849 |
T20744 |
T20742 |
compound |
cow,model |
R5850 |
T20745 |
T20742 |
cc |
and,model |
R5851 |
T20746 |
T20747 |
compound |
MSUD,humans |
R5852 |
T20747 |
T20742 |
conj |
humans,model |
R5853 |
T20748 |
T20749 |
punct |
[,1 |
R5854 |
T20749 |
T20734 |
parataxis |
1,due |
R5856 |
T20750 |
T20749 |
punct |
],1 |
R5857 |
T20751 |
T20720 |
punct |
", ",is |
R5858 |
T20752 |
T20753 |
det |
this,model |
R5860 |
T20753 |
T20720 |
nsubj |
model,is |
R5861 |
T20754 |
T20720 |
advmod |
also,is |
R5862 |
T20755 |
T20720 |
prep |
of,is |
R5864 |
T20756 |
T20757 |
amod |
limited,utility |
R5866 |
T20757 |
T20755 |
pobj |
utility,of |
R5867 |
T20758 |
T20720 |
punct |
.,is |
R5868 |
T20760 |
T20761 |
prep |
In,are |
R5870 |
T20762 |
T20760 |
pobj |
contrast,In |
R5871 |
T20763 |
T20761 |
punct |
", ",are |
R5873 |
T20764 |
T20765 |
det |
the,models |
R5874 |
T20765 |
T20761 |
nsubj |
models,are |
R5875 |
T20766 |
T20765 |
amod |
murine,models |
R5877 |
T20767 |
T20765 |
acl |
described,models |
R5878 |
T20768 |
T20767 |
prep |
in,described |
R5879 |
T20769 |
T20770 |
det |
this,report |
R5881 |
T20770 |
T20768 |
pobj |
report,in |
R5882 |
T20771 |
T20772 |
advmod |
more,valid |
R5883 |
T20772 |
T20761 |
acomp |
valid,are |
R5885 |
T20773 |
T20772 |
cc |
and,valid |
R5886 |
T20774 |
T20772 |
conj |
appropriate,valid |
R5887 |
T20775 |
T20774 |
prep |
for,appropriate |
R5889 |
T20776 |
T20777 |
amod |
modeling,MSUD |
R5890 |
T20777 |
T20775 |
pobj |
MSUD,for |
R5891 |
T20778 |
T20777 |
amod |
human,MSUD |
R5893 |
T20779 |
T20761 |
punct |
.,are |