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PMC:1448208 / 35510-36409 JSONTXT

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craft-sa-dev

Id Subject Object Predicate Lexical cue
T20585 898-899 . denotes .
T20584 886-888 VB denotes be
T20583 881-885 RB denotes also
T20582 889-898 VBN denotes regulated
T20581 877-880 MD denotes can
T20580 873-876 CC denotes and
T20579 864-872 NN denotes survival
T20578 860-863 IN denotes for
T20577 854-859 VBP denotes allow
T20576 849-853 WDT denotes that
T20575 843-848 NNS denotes lines
T20574 838-842 VB denotes find
T20573 835-837 TO denotes to
T20572 825-827 VB denotes be
T20571 821-824 MD denotes may
T20570 815-820 NNS denotes lines
T20569 804-814 JJ denotes additional
T20568 801-803 IN denotes of
T20567 828-834 VBN denotes needed
T20566 791-800 NN denotes Screening
T20565 790-899 sentence denotes Screening of additional lines may be needed to find lines that allow for survival and can also be regulated.
T20564 789-790 . denotes .
T20563 779-789 NN denotes expression
T20562 769-778 VBN denotes regulated
T20561 765-768 IN denotes for
T20560 754-764 JJ denotes permissive
T20559 750-753 RB denotes not
T20558 735-745 NNS denotes transgenes
T20557 731-734 DT denotes the
T20556 728-730 IN denotes of
T20555 711-722 NN denotes integration
T20554 723-727 NN denotes site
T20553 707-710 DT denotes the
T20552 746-749 VBD denotes was
T20551 702-706 IN denotes that
T20550 690-701 JJ denotes conceivable
T20549 687-689 VBZ denotes is
T20548 684-686 PRP denotes It
T20547 683-790 sentence denotes It is conceivable that the integration site of the transgenes was not permissive for regulated expression.
T20546 682-683 . denotes .
T20545 675-682 JJ denotes unknown
T20544 660-671 NN denotes doxycycline
T20543 657-659 IN denotes to
T20542 644-656 JJ denotes unresponsive
T20541 639-643 VBD denotes were
T20540 629-632 CD denotes two
T20539 633-638 NNS denotes lines
T20538 623-628 DT denotes these
T20537 672-674 VBZ denotes is
T20536 616-622 NN denotes reason
T20535 612-615 DT denotes The
T20534 611-683 sentence denotes The reason these two lines were unresponsive to doxycycline is unknown.
T20533 610-611 . denotes .
T20532 609-610 -RRB- denotes )
T20531 600-603 RB denotes not
T20530 595-599 NNS denotes data
T20529 604-609 VBN denotes shown
T20528 594-595 -LRB- denotes (
T20527 587-593 VBN denotes tested
T20526 570-580 JJ denotes transgenic
T20525 566-569 CD denotes two
T20524 581-586 NNS denotes lines
T20523 562-565 DT denotes the
T20522 559-561 IN denotes of
T20521 552-558 DT denotes either
T20520 549-551 IN denotes in
T20519 537-548 NN denotes doxycycline
T20518 535-537 , denotes ,
T20517 514-526 NN denotes tetracycline
T20516 507-513 JJ denotes potent
T20515 527-535 NN denotes analogue
T20514 503-506 DT denotes the
T20513 500-502 IN denotes by
T20512 480-490 NN denotes expression
T20511 477-479 NN denotes E2
T20510 471-476 JJ denotes human
T20509 491-499 NN denotes cassette
T20508 467-470 DT denotes the
T20507 463-466 RP denotes off
T20506 445-457 RB denotes consistently
T20505 458-462 VB denotes turn
T20504 442-444 TO denotes to
T20503 435-441 JJ denotes unable
T20502 427-429 PRP denotes we
T20501 425-427 , denotes ,
T20500 430-434 VBD denotes were
T20499 418-425 RB denotes However
T20498 417-611 sentence denotes However, we were unable to consistently turn off the human E2 expression cassette by the potent tetracycline analogue, doxycycline in either of the two transgenic lines tested (data not shown).
T20497 416-417 . denotes .
T20496 398-406 VBG denotes rescuing
T20495 407-416 NN denotes transgene
T20494 394-397 DT denotes the
T20493 390-393 RP denotes off
T20492 382-389 VBG denotes turning
T20491 379-381 IN denotes by
T20490 365-367 POS denotes 's
T20489 368-378 NN denotes discretion
T20488 353-365 NN denotes investigator
T20487 349-352 DT denotes the
T20486 346-348 IN denotes at
T20485 328-335 JJ denotes classic
T20484 336-345 NN denotes phenotype
T20483 324-327 DT denotes the
T20482 321-323 IN denotes to
T20481 308-310 VB denotes be
T20480 302-307 MD denotes could
T20479 311-320 VBN denotes converted
T20478 297-301 WDT denotes that
T20477 282-286 NN denotes MSUD
T20476 269-281 JJ denotes intermediate
T20475 287-296 NN denotes phenotype
T20474 266-268 DT denotes an
T20473 261-265 IN denotes with
T20472 256-260 NNS denotes mice
T20471 249-255 VB denotes create
T20470 246-248 TO denotes to
T20469 233-241 NN denotes approach
T20468 229-232 PRP$ denotes our
T20467 222-228 IN denotes behind
T20466 242-245 VBD denotes was
T20465 213-221 NN denotes strategy
T20464 209-212 DT denotes The
T20463 208-417 sentence denotes The strategy behind our approach was to create mice with an intermediate MSUD phenotype that could be converted to the classic phenotype at the investigator's discretion by turning off the rescuing transgene.
T20462 207-208 . denotes .
T20461 206-207 -RRB- denotes ]
T20460 204-206 CD denotes 34
T20459 203-204 -LRB- denotes [
T20448 140-143 VBZ denotes has
T20447 149-153 VBN denotes used
T20446 135-139 WDT denotes that
T20445 121-127 NN denotes switch
T20444 116-120 NN denotes gene
T20443 106-115 VBN denotes regulated
T20442 93-105 NN denotes tetracycline
T20441 128-134 NN denotes system
T20440 89-92 DT denotes the
T20439 86-88 IN denotes on
T20438 76-79 VBD denotes was
T20437 65-69 NN denotes MSUD
T20436 52-64 JJ denotes intermediate
T20435 70-75 NN denotes model
T20434 48-51 DT denotes the
T20433 41-47 VB denotes create
T20432 38-40 TO denotes to
T20431 29-32 VBD denotes was
T20430 33-37 VBN denotes used
T20429 24-28 WDT denotes that
T20428 80-85 VBN denotes based
T20427 4-14 JJ denotes transgenic
T20426 15-23 NN denotes approach
T20425 0-3 DT denotes The
T20458 195-202 NN denotes example
T20457 191-194 IN denotes for
T20456 189-191 , denotes ,
T20455 182-189 NNS denotes studies
T20454 176-181 JJ denotes other
T20453 173-175 IN denotes in
T20452 165-172 NN denotes success
T20451 159-164 JJ denotes great
T20450 154-158 IN denotes with
T20449 144-148 VBN denotes been
R5517 T20425 T20426 det The,approach
R5518 T20426 T20428 nsubjpass approach,based
R5519 T20427 T20426 amod transgenic,approach
R5520 T20429 T20430 dep that,used
R5521 T20430 T20426 relcl used,approach
R5522 T20431 T20430 auxpass was,used
R5523 T20432 T20433 aux to,create
R5524 T20433 T20430 advcl create,used
R5525 T20434 T20435 det the,model
R5526 T20435 T20433 dobj model,create
R5527 T20436 T20435 amod intermediate,model
R5528 T20437 T20435 compound MSUD,model
R5529 T20438 T20428 auxpass was,based
R5530 T20439 T20428 prep on,based
R5531 T20440 T20441 det the,system
R5532 T20441 T20439 pobj system,on
R5533 T20442 T20443 npadvmod tetracycline,regulated
R5534 T20443 T20441 amod regulated,system
R5535 T20444 T20445 compound gene,switch
R5536 T20445 T20441 compound switch,system
R5537 T20446 T20447 dep that,used
R5538 T20447 T20441 relcl used,system
R5539 T20448 T20447 aux has,used
R5540 T20449 T20447 auxpass been,used
R5541 T20450 T20447 prep with,used
R5542 T20451 T20452 amod great,success
R5543 T20452 T20450 pobj success,with
R5544 T20453 T20447 prep in,used
R5545 T20454 T20455 amod other,studies
R5546 T20455 T20453 pobj studies,in
R5547 T20456 T20447 punct ", ",used
R5548 T20457 T20447 prep for,used
R5549 T20458 T20457 pobj example,for
R5550 T20459 T20460 punct [,34
R5551 T20460 T20428 parataxis 34,based
R5552 T20461 T20460 punct ],34
R5553 T20462 T20428 punct .,based
R5554 T20464 T20465 det The,strategy
R5555 T20465 T20466 nsubj strategy,was
R5556 T20467 T20465 prep behind,strategy
R5557 T20468 T20469 poss our,approach
R5558 T20469 T20467 pobj approach,behind
R5559 T20470 T20471 aux to,create
R5560 T20471 T20466 xcomp create,was
R5561 T20472 T20471 dobj mice,create
R5562 T20473 T20472 prep with,mice
R5563 T20474 T20475 det an,phenotype
R5564 T20475 T20473 pobj phenotype,with
R5565 T20476 T20475 amod intermediate,phenotype
R5566 T20477 T20475 compound MSUD,phenotype
R5567 T20478 T20479 dep that,converted
R5568 T20479 T20475 relcl converted,phenotype
R5569 T20480 T20479 aux could,converted
R5570 T20481 T20479 auxpass be,converted
R5571 T20482 T20479 prep to,converted
R5572 T20483 T20484 det the,phenotype
R5573 T20484 T20482 pobj phenotype,to
R5574 T20485 T20484 amod classic,phenotype
R5575 T20486 T20479 prep at,converted
R5576 T20487 T20488 det the,investigator
R5577 T20488 T20489 poss investigator,discretion
R5578 T20489 T20486 pobj discretion,at
R5579 T20490 T20488 case 's,investigator
R5580 T20491 T20479 prep by,converted
R5581 T20492 T20491 pcomp turning,by
R5582 T20493 T20492 prt off,turning
R5583 T20494 T20495 det the,transgene
R5584 T20495 T20492 dobj transgene,turning
R5585 T20496 T20495 amod rescuing,transgene
R5586 T20497 T20466 punct .,was
R5587 T20499 T20500 advmod However,were
R5588 T20501 T20500 punct ", ",were
R5589 T20502 T20500 nsubj we,were
R5590 T20503 T20500 acomp unable,were
R5591 T20504 T20505 aux to,turn
R5592 T20505 T20503 xcomp turn,unable
R5593 T20506 T20505 advmod consistently,turn
R5594 T20507 T20505 prt off,turn
R5595 T20508 T20509 det the,cassette
R5596 T20509 T20505 dobj cassette,turn
R5597 T20510 T20509 amod human,cassette
R5598 T20511 T20509 compound E2,cassette
R5599 T20512 T20509 compound expression,cassette
R5600 T20513 T20505 prep by,turn
R5601 T20514 T20515 det the,analogue
R5602 T20515 T20513 pobj analogue,by
R5603 T20516 T20515 amod potent,analogue
R5604 T20517 T20515 compound tetracycline,analogue
R5605 T20518 T20515 punct ", ",analogue
R5606 T20519 T20515 appos doxycycline,analogue
R5607 T20520 T20505 prep in,turn
R5608 T20521 T20520 pobj either,in
R5609 T20522 T20521 prep of,either
R5610 T20523 T20524 det the,lines
R5611 T20524 T20522 pobj lines,of
R5612 T20525 T20524 nummod two,lines
R5613 T20526 T20524 amod transgenic,lines
R5614 T20527 T20524 acl tested,lines
R5615 T20528 T20529 punct (,shown
R5616 T20529 T20500 parataxis shown,were
R5617 T20530 T20529 nsubj data,shown
R5618 T20531 T20529 neg not,shown
R5619 T20532 T20529 punct ),shown
R5620 T20533 T20500 punct .,were
R5621 T20535 T20536 det The,reason
R5622 T20536 T20537 nsubj reason,is
R5623 T20538 T20539 det these,lines
R5624 T20539 T20541 nsubj lines,were
R5625 T20540 T20539 nummod two,lines
R5626 T20541 T20536 advcl were,reason
R5627 T20542 T20541 acomp unresponsive,were
R5628 T20543 T20542 prep to,unresponsive
R5629 T20544 T20543 pobj doxycycline,to
R5630 T20545 T20537 acomp unknown,is
R5631 T20546 T20537 punct .,is
R5632 T20548 T20549 nsubj It,is
R5633 T20550 T20549 acomp conceivable,is
R5634 T20551 T20552 mark that,was
R5635 T20552 T20549 ccomp was,is
R5636 T20553 T20554 det the,site
R5637 T20554 T20552 nsubj site,was
R5638 T20555 T20554 compound integration,site
R5639 T20556 T20554 prep of,site
R5640 T20557 T20558 det the,transgenes
R5641 T20558 T20556 pobj transgenes,of
R5642 T20559 T20552 neg not,was
R5643 T20560 T20552 acomp permissive,was
R5644 T20561 T20560 prep for,permissive
R5645 T20562 T20563 amod regulated,expression
R5646 T20563 T20561 pobj expression,for
R5647 T20564 T20549 punct .,is
R5648 T20566 T20567 nsubjpass Screening,needed
R5649 T20568 T20566 prep of,Screening
R5650 T20569 T20570 amod additional,lines
R5651 T20570 T20568 pobj lines,of
R5652 T20571 T20567 aux may,needed
R5653 T20572 T20567 auxpass be,needed
R5654 T20573 T20574 aux to,find
R5655 T20574 T20567 advcl find,needed
R5656 T20575 T20574 dobj lines,find
R5657 T20576 T20577 dep that,allow
R5658 T20577 T20575 relcl allow,lines
R5659 T20578 T20577 prep for,allow
R5660 T20579 T20578 pobj survival,for
R5661 T20580 T20577 cc and,allow
R5662 T20581 T20582 aux can,regulated
R5663 T20582 T20577 conj regulated,allow
R5664 T20583 T20582 advmod also,regulated
R5665 T20584 T20582 auxpass be,regulated
R5666 T20585 T20567 punct .,needed

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19765 889-898 GO:0065007 denotes regulated
T19764 779-789 GO:0010467 denotes expression
T19763 769-778 GO:0065007 denotes regulated
T19762 735-745 SO_EXT:0000902 denotes transgenes
T19761 711-727 SO_EXT:0000366 denotes integration site
T19760 660-671 CHEBI:50845 denotes doxycycline
T19759 570-580 SO_EXT:transgenic_entity denotes transgenic
T19758 537-548 CHEBI:50845 denotes doxycycline
T19757 514-526 CHEBI:27902 denotes tetracycline
T19756 491-499 SO_EXT:0005853 denotes cassette
T19755 480-490 GO:0010467 denotes expression
T19754 477-479 PR_EXT:000006300 denotes E2
T19753 471-476 NCBITaxon:9606 denotes human
T19752 407-416 SO_EXT:0000902 denotes transgene
T19751 398-406 SO_EXT:sequence_rescue_process denotes rescuing
T19750 256-260 NCBITaxon:10088 denotes mice
T19749 116-120 SO_EXT:0000704 denotes gene
T19748 106-115 GO:0065007 denotes regulated
T19747 93-105 CHEBI:27902 denotes tetracycline
T19746 4-14 SO_EXT:transgenic_entity denotes transgenic

craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T19604 889-898 GO:0065007 denotes regulated
T19603 779-789 GO:0010467 denotes expression
T19602 769-778 GO:0065007 denotes regulated
T19601 735-745 SO:0000902 denotes transgenes
T19600 711-727 SO:0000366 denotes integration site
T19599 660-671 CHEBI:50845 denotes doxycycline
T19598 537-548 CHEBI:50845 denotes doxycycline
T19597 514-526 CHEBI:27902 denotes tetracycline
T19596 491-499 SO:0005853 denotes cassette
T19595 480-490 GO:0010467 denotes expression
T19594 477-479 PR:000006300 denotes E2
T19593 471-476 NCBITaxon:9606 denotes human
T19592 407-416 SO:0000902 denotes transgene
T19591 256-260 NCBITaxon:10088 denotes mice
T19590 116-120 SO:0000704 denotes gene
T19589 106-115 GO:0065007 denotes regulated
T19588 93-105 CHEBI:27902 denotes tetracycline